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3 results on '"Hypo-responders"'

1. The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis

Author

Alessandro Conforti, Sandro C. Esteves, Francesca Di Rella, Ida Strina, Pasquale De Rosa, Alessia Fiorenza, Fulvio Zullo, Giuseppe De Placido, and Carlo Alviggi

Subjects
LH, Recombinant LH, Hypo-responders, Assisted reproductive technologies, In vitro fertilization, Ovulation induction, Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
Abstract

Abstract Objective To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation. Methods We performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Primary outcome was clinical pregnancy rate. Results Significantly higher clinical pregnancy rates (odds ratio: 2.03, P = 0.003), implantation rates (odds ratio: 2.62, P = 0.004) and number of oocytes retrieved (weight mean differences: 1.98, P = 0.03) were observed in hypo-responders supplemented with recombinant LH versus hypo-responders who underwent FSH monotherapy. No differences in terms of mature oocytes or miscarriage rates were found between the two groups. Conclusion In conclusion, our analysis confirms that women with a hypo-response to exogenous gonadotropins might benefit from LH supplementation. However, more trials are required before a definitive conclusion can be drawn.

Published
2019
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2. The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: a systematic review and meta-analysis.

Author

Conforti, Alessandro, Esteves, Sandro C., Di Rella, Francesca, Strina, Ida, De Rosa, Pasquale, Fiorenza, Alessia, Zullo, Fulvio, De Placido, Giuseppe, and Alviggi, Carlo

Subjects
META-analysis, OVUM, GONADOTROPIN, ODDS ratio, WOMEN, INDUCED ovulation, MISCARRIAGE
Abstract

Objective: To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation. Methods: We performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Primary outcome was clinical pregnancy rate. Results: Significantly higher clinical pregnancy rates (odds ratio: 2.03, P = 0.003), implantation rates (odds ratio: 2.62, P = 0.004) and number of oocytes retrieved (weight mean differences: 1.98, P = 0.03) were observed in hypo-responders supplemented with recombinant LH versus hypo-responders who underwent FSH monotherapy. No differences in terms of mature oocytes or miscarriage rates were found between the two groups. Conclusion: In conclusion, our analysis confirms that women with a hypo-response to exogenous gonadotropins might benefit from LH supplementation. However, more trials are required before a definitive conclusion can be drawn. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

3. The role of recombinant LH in women with hypo-response to controlled ovarian stimulation: A systematic review and meta-analysis

Author

Sandro C. Esteves, Pasquale De Rosa, Fulvio Zullo, Alessia Fiorenza, Alessandro Conforti, Carlo Alviggi, Ida Strina, Giuseppe De Placido, Francesca Di Rella, Conforti, A., Esteves, S. C., Di Rella, F., Strina, I., De Rosa, P., Fiorenza, A., Zullo, F., De Placido, G., and Alviggi, C.

Subjects
0301 basic medicine, LH, Pregnancy Rate, medicine.medical_treatment, Hypo-responders, Physiology, Stimulation, Review, Miscarriage, 0302 clinical medicine, Endocrinology, Pregnancy, In vitro fertilization, lcsh:Reproduction, Prospective Studies, Gonadotropin, Clinical Trials as Topic, 030219 obstetrics & reproductive medicine, Recombinant LH, Obstetrics and Gynecology, Recombinant Proteins, Meta-analysis, Hypo-responder, Female, Assisted reproductive technologies, Human, medicine.medical_specialty, lcsh:QH471-489, Ovulation induction, Reproductive medicine, lcsh:Gynecology and obstetrics, 03 medical and health sciences, medicine, Assisted reproductive technologie, Humans, Embryo Implantation, lcsh:RG1-991, In vitro fertilisation, business.industry, Correction, Odds ratio, Luteinizing Hormone, medicine.disease, Clinical trial, Prospective Studie, 030104 developmental biology, Reproductive Medicine, Follicle Stimulating Hormone, business, Gonadotropins, Developmental Biology
Abstract

Objective To study the role of recombinant human LH supplementation in women with hypo-response to ovarian stimulation. Methods We performed a systematic review and meta-analysis of prospective clinical trials in which recombinant FSH monotherapy protocols were compared with LH-supplemented protocols in hypo-responders. A search was conducted of the Scopus, MEDLINE databases without time or language restrictions. Primary outcome was clinical pregnancy rate. Results Significantly higher clinical pregnancy rates (odds ratio: 2.03, P = 0.003), implantation rates (odds ratio: 2.62, P = 0.004) and number of oocytes retrieved (weight mean differences: 1.98, P = 0.03) were observed in hypo-responders supplemented with recombinant LH versus hypo-responders who underwent FSH monotherapy. No differences in terms of mature oocytes or miscarriage rates were found between the two groups. Conclusion In conclusion, our analysis confirms that women with a hypo-response to exogenous gonadotropins might benefit from LH supplementation. However, more trials are required before a definitive conclusion can be drawn. Electronic supplementary material The online version of this article (10.1186/s12958-019-0460-4) contains supplementary material, which is available to authorized users.

Published
2019

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