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2. A prospective multicentre surveillance study to investigate the risk associated with contaminated sinks in the intensive care unit

Author

Abdoush, H., Alfandari, S., Allaire, A., Aloe, L., Andreo, A., Antoine, E., Aurel, C., Azaouzi, A., Barry-Perdereau, V., Berrouane, Y., Blaise, S., Blanie, M., Bonjean, S., Borderan, G.C., Bounoua, M., Bourigault, C., Brean, V., Cecille, A., Chakaroun, H., Chanay, O., Chauvin, C., Curnier, V., Dalmas, H., Degallaix, D., Del Guidice, F., Delhomme, J., Demasure, M., Denis, C., Diaw, F., Dorel, S., Fourneret-Vivier, A., Fradin, B., Fribourg, A., Fumery, B., Gallais, S., Gazagne, L., Genillon, J.P., Gerbier, C., Glanard, A., Gouin, C., Gourmelen, F., Haond, C., Huart, C., Idri, N., Ionescu, P., Joron, S., Joseph, E., Labonne, V., Laurent, B., Le Coq, M., Lecuru, M., Legrand, A., Lehiani, O., Lepainteur, M., Lesteven, C., Llorens, M., Lugagne, N., Magneney, M., Mahamat, A., Marie, V., Mattioli, K., Mesnil, M., Mien, S., Morange, V., Negrin, N., Neulier, C., Ory, J., Ouzani, S., Perez, A., Pospisil, F., Sevin, T., Thomas-Hervieu, A., Valdes, A., Victoire, C., Vidal-Hollaender, B., Veyres, P., Zamfir, O., Anguel, N., Aussant, P., Badetti, C., Bavozet, F., Bayekula, J., Bedon-Carte, S., Bedos, J.P., Berthon, M., Bertrand, P.M., Brunel, E., Burel, C., Cerf, C., Chelha, R., Combaux, D., Da Silva, D., Damoisel, C., De Rudnicki, S., Debost, J., Desfrere, L., Della-Guardia, M., Dieye, E., Eisenmann, N., Ethuin, F., Favier, L., Fedun, S., Feller, M., Ferreira, L., Fillatre, P., Galin, X., Garot, D., Duclos, J. Gaubert, Gette, S., Georges, H., Godde, F., Hamet, M., Hira, M., Hoff, J., Hyvernat, H., Illinger, J., Jacques, L., Joubert, J., Kaidomar, M., Kalfon, P., Kallel, H., Lafforgue, P., Lambiotte, F., Landivier, A., Lazard, T., Le Gall, F., M'fam, W., Mariot, J., Martin, A., Martinet, O., Michaux, P., Michel, O., Mofredj, A., Montini, F., Muller, L., Pommier, C., Pottie, J.C., Prevost, F., Roger, C., Samat, C., Serpin, L., Siami, S., Alaoui, S. Sidki, Simaillaud, A., Simonoviez, P.Y., Slimani, H., Thouret, J.M., Toledano, D., Travert, B., Trouiller, P., Trouillet, G., Vescovali, C., Adochitei, A., Amara, M., Arsene, S., Bachelier, M.N., Barrans, A., Belmonte, O., Ben Hadj Yahia, S., Bensaid, T., Beretta-Salaun, G., Bertei, D., Bizet, J., Bleunven, S., Bonfils, F., Bonnet, R., Brisou, P., Cantet, P., Cattoen, C., Chaplain, C., Cordoleani, B., Dao, A., Dorangeon, E., Dupin, C., Farfour, E., Farrugia, C., Fines, M., Fougnot, S., Garnier, P., Guerin, M., Guillet-Caruba, C., Guinard, J., Goux, A., Hammami, S., Heusse, E., Heym, B., Alet, C. Hombrouck, Jacquemin, P., Jensen, C., Lacomme, M.P., Lafay, E., Lance, F., Lanselle, C., Lavigne, J.P., Le Gallou, F., Lechat, S., Lemenand, O., Leotard, S., Levast, M., Louis, G., Lourtet, J., Luizy, N., Mereghetti, L., Mignot, L., Moquet, O., Navarrot, J.C., Lory, M. Pancher, Parmeland, L., Patoz, P., Poussing, S., Ragot, C., Roudiere, L., Ruimy, R., Rose, V. Sainte, Sanchez, R., Seraphin, H., Vanson, M.l., Valentin, Anne-Sophie, Santos, Sandra Dos, Goube, Florent, Gimenes, Rémi, Decalonne, Marie, Mereghetti, Laurent, Daniau, Côme, and van der Mee-Marquet, Nathalie

Published
2021
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3. Patient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock

Author

Pirracchio, R, Annane, D, Waschka, AK, Lamontagne, F, Arabi, YM, Bollaert, P-E, Billot, L, Du, B, Briegel, J, Cohen, J, Finfer, S, Gordon, A, Hammond, N, Hyvernat, H, Keh, D, Li, Y, Liu, L, Meduri, GU, Mirea, L, Myburgh, JA, Sprung, CL, Tilouche, N, Tongyoo, S, Venkatesh, B, Zheng, R, Delaney, A, and NIHR

Abstract

BACKGROUND Trials and study-level meta-analyses have failed to resolve the role of corticosteroids in the management of patients with septic shock. Patient-level meta-analyses may provide more precise estimates of treatment effects, particularly subgroup effects. METHODS We pooled individual patient data from septic shock trials investigating the adjunctive use of intravenous hydrocortisone. The primary outcome was 90-day all-cause mortality, and it was also analyzed across predefined subgroups. Secondary outcomes included mortality at intensive care unit and hospital discharge, at 28 and 180 days, and vasopressor-, ventilator-, and organ failure–free days. Adverse events included superinfection, muscle weakness, hyperglycemia, hypernatremia, and gastroduodenal bleeding. RESULTS Of 24 eligible trials (n=8528), 17 (n=7882) provided individual patient data, and 7 (n=5929) provided 90-day mortality. The marginal relative risk (RR) for 90-day mortality of hydrocortisone versus placebo was 0.93 (95% confidence interval [CI], 0.82 to 1.04; P=0.22; moderate certainty). It was 0.86 (9% CI, 0.79 to 0.92) for hydrocortisone with fludrocortisone and 0.96 (95% CI, 0.82 to 1.12) without fludrocortisone. There was no significant differential treatment effect across subgroups. Hydrocortisone was associated with little to no difference in any of the secondary outcomes except vasopressor-free days (mean difference, 1.24 days; 95% CI, 0.74 to 1.73; high certainty). Hydrocortisone may not be associated with an increase in the risk of superinfection (RR, 1.04; 95% CI, 0.95 to 1.15; low certainty), hyperglycemia (RR, 1.05; 95% CI, 0.98 to 1.12; low certainty), or gastroduodenal bleeding (RR, 1.11; 95% CI, 0.83 to 1.48; low certainty). Hydrocortisone may be associated with an increase in the risk of hypernatremia (RR, 2.01; 95% CI, 1.56 to 2.60; low certainty) and muscle weakness (n=2647; RR, 1.73; 95% CI, 1.49 to 1.99; low certainty). CONCLUSIONS In this patient-level meta-analysis, hydrocortisone compared with placebo was not associated with reduced mortality for patients with septic shock. (Funded by “Programme d’Investissements d’Avenir,” a research Professorship from the National Institute of Health and Care Research, Leadership Fellowships from the National Health and Medical Research Council of Australia, and Emerging Leaders Fellowship from the National Health and Medical Research Council of Australia; PROSPERO registration number, CRD42017062198.)

Published
2023
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5. Correction to: Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study

Author

Bruneel, Fabrice, Tubach, Florence, Mira, Jean-Paul, Houze, Sandrine, Gibot, Sebastien, Huisse, Marie-Genevieve, Megarbane, Bruno, Choquet, Christophe, Corne, Philippe, Peytel, Eric, Villers, Daniel, Camus, Christophe, Bouchaud, Olivier, Caumes, Eric, Girard, Pierre-Marie, Simon, Fabrice, Kalloumeh, Antoine, Roy, Carine, Durand, Remy, Le Bras, Jacques, Matheron, Sophie, Wolff, Michel, Mourvillier, B., Aubron, C., Bouadma, L., Regnier, B., d’Ortenzio, E., Matra, R., Bouvet, E., Tourret, J., Dorchies, J., Males, S., Rioux, C., Flicoteaux, R., Yeni, P., Spingler, F., Kargougou, E., Casalino, E., Ollivier, V., Grandchamp, B., Miri, Y., Fresnoy, E., Grelon, F., Asfar, P., Kouatchet, A., Mercat, A., Joly-Guillou, M. L., Kempf, M., Eveillard, M., Daoudal, P., Royer, A., Runge, I., Mathonnet, A., Boulain, T., Bret, L., Hocqueloux, L., Segalin, J. M., Mille, C., Niang, M., Prazuck, T., Fortin, M., Schortgen, F., Brun Buisson, C., Botterel, F., Bretagne, S., Leroy, O., Georges, H., Meybeck, A., Guery, B., Patoz, P., Dhennain, C., Chakarian, D., Azougagh, K., Bonmarchand, G., Abboud, P., Favennec, L., Lemeland, J. F., Petrognani, R., Nau, A., Puidupin, A., Carpentier, J. P., Garnotel, E., Moalic, J. L., Tual, L., Amathieu, R., Dhonneur, G., N’Diaye, M., Jeantils, V., Chassaignon, C., Guillerm, A. L., Riche, D., Javaud, N., Pevirieri, F., Benkel, J., Luis, D., Bon, M. C., Lenoir, G., Bernot, B., Collignon, A., Bemba, D., Poilane, I., Trouillet, J. L., Luyt, C. E., Mirabel, M., Chastre, J., Hochedez, P., Perignon, A., Thellier, M., Danis, M., Faussart, A., Nafziger, J., Gastinne, H., Pichon, N., Ajzenberg, D., Darde, M. L., Jacobs, F., Brivet, F., Veyradier, A., Marfaing-Koka, A., Timsit, J. F., Hammer, L., Maubon, D., Pelloux, H., Pene, F., Charpentier, J., Marque, S., Rousseau, C., Guezennec, P., Troche, G., Bedos, J. P., Eloy, O., Palette, C., Therby, A., Monnier, S., Greder-Bellan, A., Cougot, P., Kuteifan, K., Mootien, Y., Guiot, P., Delarbre, J. M., Kiefer, M. H., Page, B., Vieillard Baron, A., Dunand, J., Loubieres, Y., Ricome, J. L., Peltier, J. Y., Giudicelli, Y., Pelletier, C., Rousseau, J. M., Imbert, P., Rapp, C., Mechai, F., Barruet, R., Debord, T., Pilo, J. E., Cavallo, J. D., Angles, O., Genestal, M., Bretonnière, C., Nicolet, L., Jalin, L., Talarmin, J. P., Grossi, O., Raffi, F., Gay-Andrieu, F., Bompoil, T., Gros, A., Le Tulzo, Y., Revest, M., Fily, F., Chapplain, J. M., Tattevin, P., Michelet, C., Chevrier, S., Guigen, C., Baud, F., Launay, J. M., Gourmel, C., Derouin, F., de Miranda, S., Thiery, G., Legriel, S., Azoulay, E., Schlemmer, B., Colin de Verdieres, N., Lagrange-Xelot, M., Gallien, S., De Castro, N., Pavie, J., Lafaurie, M., Molina, J. M., Sarfati, C., Derouin, F., Jonquet, P., Schved, J. F., Biron, C., Bret, C., Klouche, K., Beraud, P., Cristol, J. P., Gruson, D., Herpe, B., Delacre, M., Castaing, Y., Fialon, P., Vincendeau, P., Vincent, F., Karoubi, P., Cohen, Y., Cordel, H., Prendki, V., Cailhol, J., Abgrall, S., Gros, H., Fantinato, C., Cymbalista, F., Senghor, Y., Memain, N., Thuong, M., Adrie, C., Darques, L., Moret, G., Fraisse, F., Godineau, N., Chaplain, C., Prevel, M., Mary, R. J., Plantefeve, G., Bleichner, G., Mentec, H., Leturdu, F., Hyvernat, H., Bernardin, G., Delaunay, P., Marty, P., Baudel, J. L., Maury, E., Offenstadt, G., Meynard, J. L., Pacanowski, J., Ouazene, Z., Bollens, D., Meyohas, M. C., Fonquerine, L., Belkadi, G., Magne, D., Roux, P., Rusel, L., Ricard, J. D., Dreyfuss, D., Mortier, E., Vinceneux, P., Bloch, M., Galeazzi, G., Charbonneau, P., Duhamel, C., Leclercq, R., Delassus, J. L., Malbec, D., Lusina, D., Broutier, H., Charlier, C., Lanternier, F., Coignard, H., Lortholary, O., Bougnoux, M. E., Consigny, P. H., Simons de Fanti, A., Leguern, A. S., Massin, F., and The PALUREA Study Group

Published
2017
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6. A prospective multicentre surveillance study to investigate the risk associated with contaminated sinks in the intensive care unit

Author

Valentin, Anne-Sophie, primary, Santos, Sandra Dos, additional, Goube, Florent, additional, Gimenes, Rémi, additional, Decalonne, Marie, additional, Mereghetti, Laurent, additional, Daniau, Côme, additional, van der Mee-Marquet, Nathalie, additional, Abdoush, H., additional, Alfandari, S., additional, Allaire, A., additional, Aloe, L., additional, Andreo, A., additional, Antoine, E., additional, Aurel, C., additional, Azaouzi, A., additional, Barry-Perdereau, V., additional, Berrouane, Y., additional, Blaise, S., additional, Blanie, M., additional, Bonjean, S., additional, Borderan, G.C., additional, Bounoua, M., additional, Bourigault, C., additional, Brean, V., additional, Cecille, A., additional, Chakaroun, H., additional, Chanay, O., additional, Chauvin, C., additional, Curnier, V., additional, Dalmas, H., additional, Degallaix, D., additional, Del Guidice, F., additional, Delhomme, J., additional, Demasure, M., additional, Denis, C., additional, Diaw, F., additional, Dorel, S., additional, Fourneret-Vivier, A., additional, Fradin, B., additional, Fribourg, A., additional, Fumery, B., additional, Gallais, S., additional, Gazagne, L., additional, Genillon, J.P., additional, Gerbier, C., additional, Glanard, A., additional, Gouin, C., additional, Gourmelen, F., additional, Haond, C., additional, Huart, C., additional, Idri, N., additional, Ionescu, P., additional, Joron, S., additional, Joseph, E., additional, Labonne, V., additional, Laurent, B., additional, Le Coq, M., additional, Lecuru, M., additional, Legrand, A., additional, Lehiani, O., additional, Lepainteur, M., additional, Lesteven, C., additional, Llorens, M., additional, Lugagne, N., additional, Magneney, M., additional, Mahamat, A., additional, Marie, V., additional, Mattioli, K., additional, Mesnil, M., additional, Mien, S., additional, Morange, V., additional, Negrin, N., additional, Neulier, C., additional, Ory, J., additional, Ouzani, S., additional, Perez, A., additional, Pospisil, F., additional, Sevin, T., additional, Thomas-Hervieu, A., additional, Valdes, A., additional, Victoire, C., additional, Vidal-Hollaender, B., additional, Veyres, P., additional, Zamfir, O., additional, Anguel, N., additional, Aussant, P., additional, Badetti, C., additional, Bavozet, F., additional, Bayekula, J., additional, Bedon-Carte, S., additional, Bedos, J.P., additional, Berthon, M., additional, Bertrand, P.M., additional, Brunel, E., additional, Burel, C., additional, Cerf, C., additional, Chelha, R., additional, Combaux, D., additional, Da Silva, D., additional, Damoisel, C., additional, De Rudnicki, S., additional, Debost, J., additional, Desfrere, L., additional, Della-Guardia, M., additional, Dieye, E., additional, Eisenmann, N., additional, Ethuin, F., additional, Favier, L., additional, Fedun, S., additional, Feller, M., additional, Ferreira, L., additional, Fillatre, P., additional, Galin, X., additional, Garot, D., additional, Duclos, J. Gaubert, additional, Gette, S., additional, Georges, H., additional, Godde, F., additional, Hamet, M., additional, Hira, M., additional, Hoff, J., additional, Hyvernat, H., additional, Illinger, J., additional, Jacques, L., additional, Joubert, J., additional, Kaidomar, M., additional, Kalfon, P., additional, Kallel, H., additional, Lafforgue, P., additional, Lambiotte, F., additional, Landivier, A., additional, Lazard, T., additional, Le Gall, F., additional, M'fam, W., additional, Mariot, J., additional, Martin, A., additional, Martinet, O., additional, Michaux, P., additional, Michel, O., additional, Mofredj, A., additional, Montini, F., additional, Muller, L., additional, Pommier, C., additional, Pottie, J.C., additional, Prevost, F., additional, Roger, C., additional, Samat, C., additional, Serpin, L., additional, Siami, S., additional, Alaoui, S. Sidki, additional, Simaillaud, A., additional, Simonoviez, P.Y., additional, Slimani, H., additional, Thouret, J.M., additional, Toledano, D., additional, Travert, B., additional, Trouiller, P., additional, Trouillet, G., additional, Vescovali, C., additional, Adochitei, A., additional, Amara, M., additional, Arsene, S., additional, Bachelier, M.N., additional, Barrans, A., additional, Belmonte, O., additional, Ben Hadj Yahia, S., additional, Bensaid, T., additional, Beretta-Salaun, G., additional, Bertei, D., additional, Bizet, J., additional, Bleunven, S., additional, Bonfils, F., additional, Bonnet, R., additional, Brisou, P., additional, Cantet, P., additional, Cattoen, C., additional, Chaplain, C., additional, Cordoleani, B., additional, Dao, A., additional, Dorangeon, E., additional, Dupin, C., additional, Farfour, E., additional, Farrugia, C., additional, Fines, M., additional, Fougnot, S., additional, Garnier, P., additional, Guerin, M., additional, Guillet-Caruba, C., additional, Guinard, J., additional, Goux, A., additional, Hammami, S., additional, Heusse, E., additional, Heym, B., additional, Alet, C. Hombrouck, additional, Jacquemin, P., additional, Jensen, C., additional, Lacomme, M.P., additional, Lafay, E., additional, Lance, F., additional, Lanselle, C., additional, Lavigne, J.P., additional, Le Gallou, F., additional, Lechat, S., additional, Lemenand, O., additional, Leotard, S., additional, Levast, M., additional, Louis, G., additional, Lourtet, J., additional, Luizy, N., additional, Mereghetti, L., additional, Mignot, L., additional, Moquet, O., additional, Navarrot, J.C., additional, Lory, M. Pancher, additional, Parmeland, L., additional, Patoz, P., additional, Poussing, S., additional, Ragot, C., additional, Roudiere, L., additional, Ruimy, R., additional, Rose, V. Sainte, additional, Sanchez, R., additional, Seraphin, H., additional, and Vanson, M.l., additional

Published
2021
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14. Plasmaphérèse de sauvetage dans une maladie des agglutinines froides : leçons tirées d’un cas d’anémie hémolytique hyperaiguë et de défaillance rénale

Author

Agbekodo, S., primary, Calleja, A., additional, Kouchit, Y., additional, Panicucci, E., additional, Schoulmann, A., additional, Aurenche-Mateu, D., additional, Morand, L., additional, Doyen, D., additional, Dellamonica, J., additional, Hyvernat, H., additional, Buscot, M., additional, and Martis, N., additional

Published
2019
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24. Cessation of oral anticoagulants in antiphospholipid syndrome

Author

Comarmond, C, primary, Jego, P, additional, Veyssier-Belot, C, additional, Marie, I, additional, Mekinian, A, additional, Elmaleh-Sachs, A, additional, Leroux, G, additional, Saadoun, D, additional, Oziol, E, additional, Fraisse, T, additional, Hyvernat, H, additional, Thiercein-Legrand, M-F, additional, Sarrot-Reynauld, F, additional, Ferreira-Maldent, N, additional, de Menthon, M, additional, Goujard, C, additional, Khau, D, additional, Nguen, Y, additional, Monnier, S, additional, Michon, A, additional, Castel, B, additional, Decaux, O, additional, Piette, J-C, additional, and Cacoub, P, additional

Published
2017
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26. Community-acquired pneumonia and positive urinary antigen tests: Factors associated with targeted antibiotic therapy

Author

Mothes, A., primary, Léotard, S., additional, Nicolle, I., additional, Smets, A., additional, Chirio, D., additional, Rotomondo, C., additional, Tiger, F., additional, Del Giudice, P., additional, Perrin, C., additional, Néri, D., additional, Foucault, C., additional, Della Guardia, M., additional, Hyvernat, H., additional, and Roger, P.-M., additional

Published
2016
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44. Un tremblement sans fin

Author

Tieulié, N., primary, Hyvernat, H., additional, Bonnan, S., additional, Corcelle, P., additional, and Mattei, M., additional

Published
2000
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45. Une méningite atypique

Author

Tieulié, N., primary, Hyvernat, H., additional, Bonnan, S., additional, Tamisier, R., additional, Corcelle, P., additional, and Mattei, M., additional

Published
2000
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49. Une ischémie aiguë de membre

Author

Dupont, P., primary, Hyvernat, H., additional, Roux, L., additional, Vasquez, J.-L., additional, Maindivide, J., additional, Bousquet, A., additional, and Vincent, J.-F., additional

Published
1996
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