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to study risk factors of arterial hypertension (AH), their significance for AH pathogenesis in atomic power plants employees occupationally exposed to long-term ionizing radiation in a "low" dose range (cumulative external radiation doses in the range up 1 Sv). The case-control study was carried in the cohort of workers aged 40-50 ever employed at the Siberian Group of Chemical Enterprises (SGCE) between 2003-2005. 970 persons were examined by standardized epidemiological methods. "Case" (n = 359) was found to be a recent AH case (less than 3 years) in SGCE employees whose average length of service is 3 years. "Control" (n = 611) - healthy men of the same age, length of service and working conditions. Risk of AH development (odds ratio (OR) = 1.6 (1.1; 2.37) was found to be higher in radiation workers in comparison with non-radiation ones without any linear dependence of risk upon cumulative external gamma-radiation dose in the range under study (OR in a cumulative external radiation dose range 7.3-21.3 mSv = 1.6 (0.96; 2.51); OR in a cumulative external radiation dose range 21.4-68.5 mSv = 1.7 (1.04; 2.67); OR in a cumulative external radiation dose range 68.6-864 mSv = 1.6 (1.01; 2.57). Not only traditional risk factors such as: obesity (OR = 7.1 (5.06; 10.1), frequent alcohol usage (OR = 1.3 (1.06; 1.63)), dyslipidemia (OR = 2.1 (1.61; 2.08)); hyperhomocisteinemia (OR = 1.4 (1.09; 1.72)); psychoemotional (OR = 1.4(1.11; 1.89)), hereditary aggravation (OR = 2.2 (1.75; 2.9)) in SGCE personnel, but also technogenic explosion descriptions are related to AH development. The long-term occupational external gamma-radiation in a dose range up 1 Sv potentiates a negative influence of CVD traditional risk factors (for hypercholesterinemia OR = 1.9 (1.3; 2.9), for AH OR = 3.1 (2.2; 4.6)) that leads to increase in risk coefficients for 30-60% in persons exposed to traditional and technogenic factors impact (for hypercholesterinemia and ionizing radiation OR = 2.5 (1.7; 3.2); for AH and IR OR = 3.9 (2.8; 5.2)) in comparison with non-radiation personnel.

A selective cross-sectional study based on Regional Medico-Dosimetric Register was carried out in some Siberian Group of Chemical Enterprises (SGCE) workers (aged 40-50) with the aim of studying the most important risk factors prevalence for cardiovascular diseases development. 2010 persons examined with the use of standardized epidemiological methods made up 32.6% of total SGCE personnel aged 40-50.the study of risk factors of cardiovascular diseases, their prevalence, intensity and significance in atomic power plants workers exposed to occupational long-term ionizing radiation in a "low" dose range (cumulative doses in the range up to 1 Sv). The study of prevalence of risk factors for CVDs development in men occupationally exposed to ionizing radiation revealed frequent changes in the type of work performed, higher levels of psychoemotional tension, as well as high prevalence of low levels of high-density lipoprotein cholesterol (HDL-cholesterol) and obesity. Women workers of the main production were found to have hypercholesterolaemia more often than those of the auxiliary production. Annual health checks of nuclear workers should be extended to include waist and hips measurement, body mass index (BMI) calculation, lipid factors evaluation, as well as stress tests (bicycle and/or stress echocardiography) in case there are three or more risk factors for CVDs for workers of the main production.

The authors presented results of single-stage cross study of randomized select from a cohort of long seniority workers of isotope separation plant in Siberian Chemical Enterprise, with studies of inflammation markers, vascular and platelet hemostasis, serum lipid parameters, calculated atherogeneity coefficient, homocysteine levels. Serum atherogeneity coefficient and inflammation markers levels (fibrinogen, C-reactive protein) could be considered as the most informative laboratory indicators of underlying cardiovascular diseases in individuals without ischemic heart disease. Among a list of standard inductors of platelet aggregation, collagen and epinephrine should be considered preferential. Increased platelet aggregation requires disaggregant therapy, especially in smokers. Increased homocysteine level is associated with high frequency of atherosclerotic plaques and smoking.