488 results on '"I., Richter"'
Search Results
2. BepiColombo mission confirms stagnation region of Venus and reveals its large extent
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M. Persson, S. Aizawa, N. André, S. Barabash, Y. Saito, Y. Harada, D. Heyner, S. Orsini, A. Fedorov, C. Mazelle, Y. Futaana, L. Z. Hadid, M. Volwerk, G. Collinson, B. Sanchez-Cano, A. Barthe, E. Penou, S. Yokota, V. Génot, J. A. Sauvaud, D. Delcourt, M. Fraenz, R. Modolo, A. Milillo, H.-U. Auster, I. Richter, J. Z. D. Mieth, P. Louarn, C. J. Owen, T. S. Horbury, K. Asamura, S. Matsuda, H. Nilsson, M. Wieser, T. Alberti, A. Varsani, V. Mangano, A. Mura, H. Lichtenegger, G. Laky, H. Jeszenszky, K. Masunaga, C. Signoles, M. Rojo, and G. Murakami
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Science - Abstract
BepiColombo mission had two Venus flybys on its way to Mercury. Here, the authors show that during its second flyby of Venus BepiColombo has crossed the stagnation region, which was predicted by the models.
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- 2022
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3. Multispacecraft Observations of a Widespread Solar Energetic Particle Event on 2022 February 15–16
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L. Y. Khoo, B. Sánchez-Cano, C. O. Lee, L. Rodríguez-García, A. Kouloumvakos, E. Palmerio, F. Carcaboso, D. Lario, N. Dresing, C. M. S. Cohen, D. J. McComas, B. J. Lynch, F. Fraschetti, I. C. Jebaraj, J. G. Mitchell, T. Nieves-Chinchilla, V. Krupar, D. Pacheco, J. Giacalone, H.-U. Auster, J. Benkhoff, X. Bonnin, E. R. Christian, B. Ehresmann, A. Fedeli, D. Fischer, D. Heyner, M. Holmström, R. A. Leske, M. Maksimovic, J. Z. D. Mieth, P. Oleynik, M. Pinto, I. Richter, J. Rodríguez-Pacheco, N. A. Schwadron, D. Schmid, D. Telloni, A. Vecchio, and M. E. Wiedenbeck
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Solar energetic particles ,Heliosphere ,Solar coronal mass ejections ,Astrophysics ,QB460-466 - Abstract
On 2022 February 15–16, multiple spacecraft measured one of the most intense solar energetic particle (SEP) events observed so far in Solar Cycle 25. This study provides an overview of interesting observations made by multiple spacecraft during this event. Parker Solar Probe (PSP) and BepiColombo were close to each other at 0.34–0.37 au (a radial separation of ∼0.03 au) as they were impacted by the flank of the associated coronal mass ejection (CME). At about 100° in the retrograde direction and 1.5 au away from the Sun, the radiation detector on board the Curiosity surface rover observed the largest ground-level enhancement on Mars since surface measurements began. At intermediate distances (0.7–1.0 au), the presence of stream interaction regions (SIRs) during the SEP arrival time provides additional complexities regarding the analysis of the distinct contributions of CME-driven versus SIR-driven events in observations by spacecraft such as Solar Orbiter and STEREO-A, and by near-Earth spacecraft like ACE, SOHO, and WIND. The proximity of PSP and BepiColombo also enables us to directly compare their measurements and perform cross-calibration for the energetic particle instruments on board the two spacecraft. Our analysis indicates that energetic proton measurements from BepiColombo and PSP are in reasonable agreement with each other to within a factor of ∼1.35. Finally, this study introduces the various ongoing efforts that will collectively improve our understanding of this impactful, widespread SEP event.
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- 2024
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4. Venus's induced magnetosphere during active solar wind conditions at BepiColombo's Venus 1 flyby
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M. Volwerk, B. Sánchez-Cano, D. Heyner, S. Aizawa, N. André, A. Varsani, J. Mieth, S. Orsini, W. Baumjohann, D. Fischer, Y. Futaana, R. Harrison, H. Jeszenszky, I. Kazumasa, G. Laky, H. Lichtenegger, A. Milillo, Y. Miyoshi, R. Nakamura, F. Plaschke, I. Richter, S. Rojas Mata, Y. Saito, D. Schmid, D. Shiota, and C. Simon Wedlund
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Science ,Physics ,QC1-999 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Out of the two Venus flybys that BepiColombo uses as a gravity assist manoeuvre to finally arrive at Mercury, the first took place on 15 October 2020. After passing the bow shock, the spacecraft travelled along the induced magnetotail, crossing it mainly in the YVSO direction. In this paper, the BepiColombo Mercury Planetary Orbiter Magnetometer (MPO-MAG) data are discussed, with support from three other plasma instruments: the Planetary Ion Camera (SERENA-PICAM) of the SERENA suite, the Mercury Electron Analyser (MEA), and the BepiColombo Radiation Monitor (BERM). Behind the bow shock crossing, the magnetic field showed a draping pattern consistent with field lines connected to the interplanetary magnetic field wrapping around the planet. This flyby showed a highly active magnetotail, with e.g. strong flapping motions at a period of ∼7 min. This activity was driven by solar wind conditions. Just before this flyby, Venus's induced magnetosphere was impacted by a stealth coronal mass ejection, of which the trailing side was still interacting with it during the flyby. This flyby is a unique opportunity to study the full length and structure of the induced magnetotail of Venus, indicating that the tail was most likely still present at about 48 Venus radii.
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- 2021
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5. Steepening of magnetosonic waves in the inner coma of comet 67P/Churyumov–Gerasimenko
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K. Ostaszewski, K.-H. Glassmeier, C. Goetz, P. Heinisch, P. Henri, S. A. Park, H. Ranocha, I. Richter, M. Rubin, and B. Tsurutani
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Science ,Physics ,QC1-999 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
We present a statistical survey of large-amplitude, asymmetric plasma and magnetic field enhancements detected outside the diamagnetic cavity at comet 67P/Churyumov–Gerasimenko from December 2014 to June 2016. Based on the concurrent observations of plasma and magnetic field enhancements, we interpret them to be magnetosonic waves. The aim is to provide a general overview of these waves' properties over the mission duration. As the first mission of its kind, the ESA Rosetta mission was able to study the plasma properties of the inner coma for a prolonged time and during different stages of activity. This enables us to study the temporal evolution of these waves and their characteristics. In total, we identified ∼ 70 000 steepened waves in the magnetic field data by means of machine learning. We observe that the occurrence of these steepened waves is linked to the activity of the comet, where steepened waves are primarily observed at high outgassing rates. No clear indications of a relationship between the occurrence rate and solar wind conditions were found. The waves are found to propagate predominantly perpendicular to the background magnetic field, which indicates their compressional nature. Characteristics like amplitude, skewness, and width of the waves were extracted by fitting a skew normal distribution to the magnetic field magnitude of individual steepened waves. With increasing mass loading, the average amplitude of the waves decreases, while the skewness increases. Using a modified 1D magnetohydrodynamic (MHD) model, we investigated if the waves can be described by the combination of nonlinear and dissipative effects. By combining the model with observations of amplitude, width and skewness, we obtain an estimate of the effective plasma diffusivity in the comet–solar wind interaction region and compare it with suitable reference values as a consistency check. At 67P/Churyumov–Gerasimenko, these steepened waves are of particular importance as they dominate the innermost interaction region for intermediate to high activity.
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- 2021
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6. Advanced calibration of magnetometers on spin-stabilized spacecraft based on parameter decoupling
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F. Plaschke, H.-U. Auster, D. Fischer, K.-H. Fornaçon, W. Magnes, I. Richter, D. Constantinescu, and Y. Narita
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Geophysics. Cosmic physics ,QC801-809 - Abstract
Magnetometers are key instruments on board spacecraft that probe the plasma environments of planets and other solar system bodies. The linear conversion of raw magnetometer outputs to fully calibrated magnetic field measurements requires the accurate knowledge of 12 calibration parameters: six angles, three gain factors, and three offset values. The in-flight determination of 8 of those 12 parameters is enormously supported if the spacecraft is spin-stabilized, as an incorrect choice of those parameters will lead to systematic spin harmonic disturbances in the calibrated data. We show that published equations and algorithms for the determination of the eight spin-related parameters are far from optimal, as they do not take into account the physical behavior of science-grade magnetometers and the influence of a varying spacecraft attitude on the in-flight calibration process. Here, we address these issues. Based on decade-long developments and experience in calibration activities at the Braunschweig University of Technology, we introduce advanced calibration equations, parameters, and algorithms. With their help, it is possible to decouple different effects on the calibration parameters, originating from the spacecraft or the magnetometer itself. A key point of the algorithms is the bulk determination of parameters and associated uncertainties. The lowest uncertainties are expected under parameter-specific conditions. By application to THEMIS-C (Time History of Events and Macroscale Interactions during Substorms) magnetometer measurements, we show where these conditions are fulfilled along a highly elliptical orbit around Earth.
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- 2019
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7. Self-employment, income, and poor with disabilities: the 2016 inclusion of people with disabilities act in Brazil
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Bruce T. Lamont, Pankaj C. Patel, and Jack I. Richter
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Economics and Econometrics - Published
- 2022
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8. Aspilapteryx magna Triberti, 1985 – a new species of speckled moth (Lepidoptera: Gracillariidae) for European and Russian faunas from the North Caucasus
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I. Richter and Yu.I. Budashkin
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lepidoptera ,gracillariidae ,aspilapteryx magna ,europe ,russia ,kabardino-balkaria ,Zoology ,QL1-991 - Abstract
The speckled moth Aspilapteryx magna Triberti, 1985 is found in Kabardino-Balkaria after the examination of the collection of Slovak entomologist Ľubomír Srnka. This species is recorded for Russia and Europe for the first time. Aspilapteryx magna was known only by the type series (3 males) from the Iran (Alborz Mountain). One specimen (also male) collected in the Caucasus was found in an automatic light trap. Both populations, Iranian and Caucasian, were found in the high mountain alpine zone, therefore we assume, that the species is a specialized inhabitant of these biotopes. As a result, the number of Europen species of Aspilapteryx Spuler, 1910 increased to six, and the number of representatives of the genus reached four species in the fauna of Russia
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- 2020
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9. The Tropical Atlantic Observing System
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G. R. Foltz, P. Brandt, I. Richter, B. Rodríguez-Fonseca, F. Hernandez, M. Dengler, R. R. Rodrigues, J. O. Schmidt, L. Yu, N. Lefevre, L. Cotrim Da Cunha, M. J. McPhaden, M. Araujo, J. Karstensen, J. Hahn, M. Martín-Rey, C. M. Patricola, P. Poli, P. Zuidema, R. Hummels, R. C. Perez, V. Hatje, J. F. Lübbecke, I. Polo, R. Lumpkin, B. Bourlès, F. E. Asuquo, P. Lehodey, A. Conchon, P. Chang, P. Dandin, C. Schmid, A. Sutton, H. Giordani, Y. Xue, S. Illig, T. Losada, S. A. Grodsky, F. Gasparin, T. Lee, E. Mohino, P. Nobre, R. Wanninkhof, N. Keenlyside, V. Garcon, E. Sánchez-Gómez, H. C. Nnamchi, M. Drévillon, A. Storto, E. Remy, A. Lazar, S. Speich, M. Goes, T. Dorrington, W. E. Johns, J. N. Moum, C. Robinson, C. Perruche, R. B. de Souza, A. T. Gaye, J. López-Parages, P.-A. Monerie, P. Castellanos, N. U. Benson, M. N. Hounkonnou, J. Trotte Duhá, R. Laxenaire, and N. Reul
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tropical Atlantic Ocean ,observing system ,weather ,climate ,hurricanes ,biogeochemistry ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
The tropical Atlantic is home to multiple coupled climate variations covering a wide range of timescales and impacting societally relevant phenomena such as continental rainfall, Atlantic hurricane activity, oceanic biological productivity, and atmospheric circulation in the equatorial Pacific. The tropical Atlantic also connects the southern and northern branches of the Atlantic meridional overturning circulation and receives freshwater input from some of the world’s largest rivers. To address these diverse, unique, and interconnected research challenges, a rich network of ocean observations has developed, building on the backbone of the Prediction and Research Moored Array in the Tropical Atlantic (PIRATA). This network has evolved naturally over time and out of necessity in order to address the most important outstanding scientific questions and to improve predictions of tropical Atlantic severe weather and global climate variability and change. The tropical Atlantic observing system is motivated by goals to understand and better predict phenomena such as tropical Atlantic interannual to decadal variability and climate change; multidecadal variability and its links to the meridional overturning circulation; air-sea fluxes of CO2 and their implications for the fate of anthropogenic CO2; the Amazon River plume and its interactions with biogeochemistry, vertical mixing, and hurricanes; the highly productive eastern boundary and equatorial upwelling systems; and oceanic oxygen minimum zones, their impacts on biogeochemical cycles and marine ecosystems, and their feedbacks to climate. Past success of the tropical Atlantic observing system is the result of an international commitment to sustained observations and scientific cooperation, a willingness to evolve with changing research and monitoring needs, and a desire to share data openly with the scientific community and operational centers. The observing system must continue to evolve in order to meet an expanding set of research priorities and operational challenges. This paper discusses the tropical Atlantic observing system, including emerging scientific questions that demand sustained ocean observations, the potential for further integration of the observing system, and the requirements for sustaining and enhancing the tropical Atlantic observing system.
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- 2019
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10. Constipation and Fecal Incontinence in the Elderly
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Benjamin I. Richter, Anthony F. Skryd, and Scott M. Smukalla
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Gastroenterology - Published
- 2022
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11. Two-point observations of low-frequency waves at 67P/Churyumov-Gerasimenko during the descent of PHILAE: comparison of RPCMAG and ROMAP
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I. Richter, H.-U. Auster, G. Berghofer, C. Carr, E. Cupido, K.-H. Fornaçon, C. Goetz, P. Heinisch, C. Koenders, B. Stoll, B. T. Tsurutani, C. Vallat, M. Volwerk, and K.-H. Glassmeier
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Science ,Physics ,QC1-999 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
The European Space Agency's spacecraft ROSETTA has reached its final destination, comet 67P/Churyumov-Gerasimenko. Whilst orbiting in the close vicinity of the nucleus the ROSETTA magnetometers detected a new type of low-frequency wave possibly generated by a cross-field current instability due to freshly ionized cometary water group particles. During separation, descent and landing of the lander PHILAE on comet 67P/Churyumov-Gerasimenko, we used the unique opportunity to perform combined measurements with the magnetometers onboard ROSETTA (RPCMAG) and its lander PHILAE (ROMAP). New details about the spatial distribution of wave properties along the connection line of the ROSETTA orbiter and the lander PHILAE are revealed. An estimation of the observed amplitude, phase and wavelength distribution will be presented as well as the measured dispersion relation, characterizing the new type of low-frequency waves. The propagation direction and polarization features will be discussed using the results of a minimum variance analysis. Thoughts about the size of the wave source will complete our study.
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- 2016
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12. Mass-loading, pile-up, and mirror-mode waves at comet 67P/Churyumov-Gerasimenko
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M. Volwerk, I. Richter, B. Tsurutani, C. Götz, K. Altwegg, T. Broiles, J. Burch, C. Carr, E. Cupido, M. Delva, M. Dósa, N. J. T. Edberg, A. Eriksson, P. Henri, C. Koenders, J.-P. Lebreton, K. E. Mandt, H. Nilsson, A. Opitz, M. Rubin, K. Schwingenschuh, G. Stenberg Wieser, K. Szegö, C. Vallat, X. Vallieres, and K.-H. Glassmeier
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Science ,Physics ,QC1-999 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
The data from all Rosetta plasma consortium instruments and from the ROSINA COPS instrument are used to study the interaction of the solar wind with the outgassing cometary nucleus of 67P/Churyumov-Gerasimenko. During 6 and 7 June 2015, the interaction was first dominated by an increase in the solar wind dynamic pressure, caused by a higher solar wind ion density. This pressure compressed the draped magnetic field around the comet, and the increase in solar wind electrons enhanced the ionization of the outflow gas through collisional ionization. The new ions are picked up by the solar wind magnetic field, and create a ring/ring-beam distribution, which, in a high-β plasma, is unstable for mirror mode wave generation. Two different kinds of mirror modes are observed: one of small size generated by locally ionized water and one of large size generated by ionization and pick-up farther away from the comet.
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- 2016
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13. Observation of a new type of low-frequency waves at comet 67P/Churyumov-Gerasimenko
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I. Richter, C. Koenders, H.-U. Auster, D. Frühauff, C. Götz, P. Heinisch, C. Perschke, U. Motschmann, B. Stoll, K. Altwegg, J. Burch, C. Carr, E. Cupido, A. Eriksson, P. Henri, R. Goldstein, J.-P. Lebreton, P. Mokashi, Z. Nemeth, H. Nilsson, M. Rubin, K. Szegö, B. T. Tsurutani, C. Vallat, M. Volwerk, and K.-H. Glassmeier
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Science ,Physics ,QC1-999 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
We report on magnetic field measurements made in the innermost coma of 67P/Churyumov-Gerasimenko in its low-activity state. Quasi-coherent, large-amplitude (δ B/B ~ 1), compressional magnetic field oscillations at ~ 40 mHz dominate the immediate plasma environment of the nucleus. This differs from previously studied cometary interaction regions where waves at the cometary ion gyro-frequencies are the main feature. Thus classical pickup-ion-driven instabilities are unable to explain the observations. We propose a cross-field current instability associated with newborn cometary ion currents as a possible source mechanism.
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- 2015
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14. Current sheets in comet 67P/Churyumov‐Gerasimenko's coma
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M. Volwerk, G. H. Jones, T. Broiles, J. Burch, C. Carr, A. J. Coates, E. Cupido, M. Delva, N. J. T. Edberg, A. Eriksson, C. Goetz, R. Goldstein, P. Henri, H. Madanian, H. Nilsson, I. Richter, K. Schwingenschuh, G. Stenberg Wieser, and K.‐H. Glassmeier
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- 2017
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15. Wave telescope technique for MMS magnetometer
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Y. Narita, F. Plaschke, R. Nakamura, W. Baumjohann, W. Magnes, D. Fischer, Z. Vörös, R. B. Torbert, C. T. Russell, R. J. Strangeway, H. K. Leinweber, K. R. Bromund, B. J. Anderson, G. Le, M. Chutter, J. A. Slavin, E. L. Kepko, J. L. Burch, U. Motschmann, I. Richter, and K.‐H. Glassmeier
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- 2016
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16. PD-0904 Clinical experiences with online adaptive radiotherapy of vulvar carcinoma
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M. Bak, N. Jensen, T. Jakobi Nøttrup, H. From Mathiesen, H. Roed, M.E.E. Sjölin, F. Kjær-Kristoffersen, V. Nordmark Hansen, and I. Richter Vogelius
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Oncology ,Radiology, Nuclear Medicine and imaging ,Hematology - Published
- 2022
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17. A comparison between VEGA 1, 2 and Giotto flybys of comet 1P/Halley: implications for Rosetta
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M. Volwerk, K.-H. Glassmeier, M. Delva, D. Schmid, C. Koenders, I. Richter, and K. Szegö
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Science ,Physics ,QC1-999 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Three flybys of comet 1P/Halley, by VEGA 1, 2 and Giotto, are investigated with respect to the occurrence of mirror mode waves in the cometosheath and field line draping in the magnetic pile-up region around the nucleus. The time interval covered by these flybys is approximately 8 days, which is also the approximate length of an orbit or flyby of Rosetta around comet 67P/Churyumov–Gerasimenko. Thus any significant changes observed around Halley are changes that might occur for Rosetta during one pass of 67P/CG. It is found that the occurrence of mirror mode waves in the cometosheath is strongly influenced by the dynamical pressure of the solar wind and the outgassing rate of the comet. Field line draping happens in the magnetic pile-up region. Changes in nested draping regions (i.e. regions with different Bx directions) can occur within a few days, possibly influenced by changes in the outgassing rate of the comet and thereby the conductivity of the cometary ionosphere.
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- 2014
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18. Solar wind interaction with comet 67P: Impacts of corotating interaction regions
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N. J. T. Edberg, A. I. Eriksson, E. Odelstad, E. Vigren, D. J. Andrews, F. Johansson, J. L. Burch, C. M. Carr, E. Cupido, K.‐H. Glassmeier, R. Goldstein, J. S. Halekas, P. Henri, C. Koenders, K. Mandt, P. Mokashi, Z. Nemeth, H. Nilsson, R. Ramstad, I. Richter, and G. Stenberg Wieser
- Published
- 2016
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19. Ion cyclotron waves during the Rosetta approach phase: a magnetic estimate of cometary outgassing
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M. Volwerk, C. Koenders, M. Delva, I. Richter, K. Schwingenschuh, M. S. Bentley, and K.-H. Glassmeier
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Science ,Physics ,QC1-999 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
A theoretical model for the ion cyclotron wave generation during the approach phase of Rosetta to 67P/Churyumov–Gerasimenko is presented. For various activity levels of the comet, the crossing of the observational threshold is determined, whose level is derived from the wave power in the undisturbed solar wind near the comet's location during the approach phase at the appropriate frequency. The Giotto flyby at 27P/Grigg–Skjellerup is used to obtain an estimate of how often water-group ion cyclotron waves are observed, and to get insight into the wave forms. At 67P/Churyumov–Gerasimenko one can expect to observe water-group ion cyclotron waves already at a distance of 600 000 km from the nucleus for a nominal outgassing rate of Q = 350 × 1023 molecules per second. The observed first location of cyclotron waves during the Rosetta approach phase will give an indication of the actual outgassing rate of the comet.
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- 2013
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20. Enzalutamid a abirateron v léčbě pacientů s metastatickým kastračně rezistentním karcinomem prostaty po podání chemoterapie.
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S., Al-Samsam, J., Bartoš, V., Šámal, J., Dvořák, H., Kolářová, and I., Richter
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- 2023
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21. Klinische Parameter – neben Emphysemausprägung und fehlender interlobärer Kollateralventilation – als Prädiktor der Effektivität einer Ventilimplantation bei fortgeschrittenem Lungenemphysem
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M Polke, J Brugger, M Rötting, N Polke, S Schuler, I Richter, R Eberhardt, FJ F Herth, and D Gompelmann
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- 2022
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22. S831 Obesity Is Associated With an Increased Risk of Colorectal Neoplasia in Patients With Inflammatory Bowel Disease
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Benjamin I. Richter, Shaili Babbar, Tamara F. Kahan, Prabhu Sasankan, Dalia Walzer, Adam Faye, Sumona Bhattacharya, and Jordan Axelrad
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Hepatology ,Gastroenterology - Published
- 2022
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23. Delirium in hospitalized COVID-19 patients: Predictors and implications for patient outcome
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Wilke, V. Sulyok, M. Stefanou, M.-I. Richter, V. Bender, B. Ernemann, U. Ziemann, U. Malek, N. Kienzle, K. Klein, C. Bunk, S. Goepel, S. Mengel, A. and Wilke, V. Sulyok, M. Stefanou, M.-I. Richter, V. Bender, B. Ernemann, U. Ziemann, U. Malek, N. Kienzle, K. Klein, C. Bunk, S. Goepel, S. Mengel, A.
- Abstract
Introduction Delirium is recognized as a severe complication of coronavirus-disease-2019 (COVID-19). COVID-19-associated delirium has been linked to worse patient outcomes and is considered to be of multifactorial origin. Here we sought to evaluate the incidence and risk factors of delirium in hospitalized COVID-19 patients, along with its impact on clinical outcome. Methods Consecutive adult COVID-19 patients admitted to a tertiary academic referral hospital between March 1st and December 31st, 2020 were included. Potential risk factors for delirium were evaluated, including: age, gender, disease severity (as per the highest WHO grading reached during admission), laboratory parameters for infection and renal function (as per their most extreme values), and presence of comorbidities. To assess the relative strength of risk factors for predicting the occurrence of delirium, we performed a random-forest survival analysis. Results 347 patients with positive COVID-19 PCR test and median age 68.2 [IQR 55.5, 80.5] years were included. Of those, 79 patients (22.8%) developed delirium, 81 (23.3%) were transferred to ICU, 58 (16.7%) died. 163 (73.8%) patients were discharged home, 13 (5.9%) to another hospital, 32 (14.5%) to nursing homes, 13 (5.9%) to rehabilitation with an overall median admission-to-discharge time of 53 [IQR 14, 195] days. The strongest predictors for the occurrence of delirium were blood urea nitrogen (minimal depth value (MD): 3.33), age (MD: 3.75), disease severity (as captured by WHO grading; MD: 3.93), leukocyte count (MD: 4.22), the presence of a neurodegenerative history (MD: 4.43), ferritin (MD: 4.46) and creatinine (MD: 4.59) levels. Conclusion The risk of delirium in COVID-19 can be stratified based on COVID-19 disease severity and–similar to delirium associated with other respiratory infections–the factors advanced age, neurodegenerative disease history, and presence of elevated infection and renal-retention parameters. Screening for these risk
- Published
- 2022
24. PO-1554 Is Dose Accumulation in online MR-guided treatment of Liver metastases Reproducible?
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K. Boye, Abraham George Smith, Mirjana Josipovic, I. Wahlstedt, C. Flensted Behrens, Mette Pøhl, Sune Darkner, Signe Risum, Jose D. Tascon-Vidarte, and I. Richter Vogelius
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Oncology ,Dose accumulation ,business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Hematology ,Nuclear medicine ,business ,Mri guided - Published
- 2021
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25. Rosetta and Mars Express observations of the influence of high solar wind pressure on the Martian plasma environment
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N. J. T. Edberg, U. Auster, S. Barabash, A. Bößwetter, D. A. Brain, J. L. Burch, C. M. Carr, S. W. H. Cowley, E. Cupido, F. Duru, A. I. Eriksson, M. Fränz, K.-H. Glassmeier, R. Goldstein, M. Lester, R. Lundin, R. Modolo, H. Nilsson, I. Richter, M. Samara, and J. G. Trotignon
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Science ,Physics ,QC1-999 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
We report on new simultaneous in-situ observations at Mars from Rosetta and Mars Express (MEX) on how the Martian plasma environment is affected by high pressure solar wind. A significant sharp increase in solar wind density, magnetic field strength and turbulence followed by a gradual increase in solar wind velocity is observed during ~24 h in the combined data set from both spacecraft after Rosetta's closest approach to Mars on 25 February 2007. The bow shock and magnetic pileup boundary are coincidently observed by MEX to become asymmetric in their shapes. The fortunate orbit of MEX at this time allows a study of the inbound boundary crossings on one side of the planet and the outbound crossings on almost the opposite side, both very close to the terminator plane. The solar wind and interplanetary magnetic field (IMF) downstream of Mars are monitored through simultaneous measurements provided by Rosetta. Possible explanations for the asymmetries are discussed, such as crustal magnetic fields and IMF direction. In the same interval, during the high solar wind pressure pulse, MEX observations show an increased amount of escaping planetary ions from the polar region of Mars. We link the high pressure solar wind with the observed simultaneous ion outflow and discuss how the pressure pulse could also be associated with the observed boundary shape asymmetry.
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- 2009
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26. Rosetta swing-by at Mars – an analysis of the ROMAP measurements in comparison with results of 3-D multi-ion hybrid simulations and MEX/ASPERA-3 data
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A. Boesswetter, U. Auster, I. Richter, M. Fränz, B. Langlais, S. McKenna-Lawlor, S. Simon, U. Motschmann, K. H. Glassmeier, N. J. T. Edberg, and R Lundin
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Science ,Physics ,QC1-999 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
The Rosetta spacecraft flew by Mars at a distance of 260 km on 25 February 2007 during a gravity assist manoeuvre. During the closest approach (CA) the lander magnetometer ROMAP was switched on. The dataset taken during this swingby provides insight into the plasma environment around Mars: in addition to a pronounced bow shock crossing Rosetta recorded the signature of the pile up region of draped magnetic field. Also the Rosetta measurements showed signatures of crustal magnetic field anomalies which can be verified by results of a crustal magnetic field model. In order to understand the measured field morphology, multi-ion hybrid simulations were performed. Some of the input parameters for the simulations were obtained from Mars Express (MEX) data which were contemporaneously collected during the Rosetta swingby. These simulations reproduces ROMAP magnetic field measurements and show that the interplanetary magnetic field pointed northward during the encounter. A spectral analysis shows upstream waves ahead of the bow shock and indicates the presence of the magnetic pile-up boundary (MPB). The multi-ion model reproduces the ion fluxes measured by MEX/ASPERA-3 and is in agreement with the measurements to within one order of magnitude.
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- 2009
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27. Building bridges between natural and social science disciplines: a standardized methodology to combine data on ecosystem quality trends
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I. Richter, B. R. Roberts, S. F. Sailley, E. Sullivan, V. V. Cheung, J. Eales, M. Fortnam, J. B. Jontila, C. Maharja, T. Ha. Nguyen, S. Pahl, R. A. Praptiwi, J. Sugardjito, J. D. C. Sumeldan, W. M. Syazwan, A. Y. Then, and M. C. Austen
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Conservation of Natural Resources ,United Nations ,Fisheries ,Humans ,Social Sciences ,General Agricultural and Biological Sciences ,General Biochemistry, Genetics and Molecular Biology ,Ecosystem - Abstract
Despite a growing interest in interdisciplinary research, systematic ways of how to integrate data from different disciplines are still scarce. We argue that successful resource management relies on two key data sources: natural science data, which represents ecosystem structure and processes, and social science data, which describes people's perceptions and understanding. Both are vital, mutually complementing information sources that can underpin the development of feasible and effective policies and management interventions. To harvest the added value of combined knowledge, a uniform scaling system is needed. In this paper, we propose a standardized methodology to connect and explore different types of quantitative data from the natural and social sciences reflecting temporal trends in ecosystem quality. We demonstrate this methodology with different types of data such as fisheries stocks and mangrove cover on the one hand and community's perceptions on the other. The example data are collected from three United Nations Educational Scientific and Cultural Organization (UNESCO) Biosphere reserves and one marine park in Southeast Asia. To easily identify patterns of convergence or divergence among the datasets, we propose heat maps using colour codes and icons for language- and education-independent understandability. Finally, we discuss the limitations as well as potential implications for resource management and the accompanying communication strategies. Building bridges between natural and social science disciplines: a standardized methodology to combine data on ecosystem quality trends
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- 2022
28. Kein erhöhtes Risiko für Kolonkarzinome nach Entfernung kolorektaler Adenome - Ergebnisse eines flächendeckenden registergestützten Follow-up.
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Enno Swart, I. Richter, Bernt-Peter Robra, and A. Gad
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- 1994
29. Social Genomics of Methamphetamine Use, HIV Viral Load, and Social Adversity
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Michael J Li, Emily I Richter, Chukwuemeka N Okafor, Mariah M Kalmin, Shareefa Dalvie, Sae Takada, Pamina M Gorbach, Steven J Shoptaw, and Steven W Cole
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Male ,Mononuclear ,HIV Infections ,Sexual and Gender Minorities (SGM/LGBT*) ,Medical and Health Sciences ,Education ,Methamphetamine ,Substance Misuse ,Sexual and Gender Minorities ,Clinical Research ,Behavioral and Social Science ,Leukocytes ,Genetics ,Humans ,Viral load ,Homosexuality, Male ,General Psychology ,Prevention ,Psychology and Cognitive Sciences ,HIV ,Homosexuality ,Genomics ,Viral Load ,Psychiatry and Mental health ,Immune system ,Infectious Diseases ,Mental Health ,Good Health and Well Being ,Leukocytes, Mononuclear ,HIV/AIDS ,Gene expression ,Public Health ,Transcriptome ,Drug Abuse (NIDA only) ,Infection ,Regular Articles - Abstract
Background Social genomics has demonstrated altered inflammatory and type I interferon (IFN) gene expression among people experiencing chronic social adversity. Adverse social experiences such as discrimination and violence are linked to stimulant misuse and HIV, conditions that dysregulate inflammatory and innate antiviral responses, leading to increased HIV viral replication and risk of chronic diseases. Purpose We aimed to determine whether methamphetamine (MA) use, unsuppressed HIV viral load (VL) (≥200 c/mL), and experienced intimate partner violence (IPV) (past 12 months) predicted inflammatory and type I IFN gene expression in HIV-positive Black and Latinx men who have sex with men (MSM). Methods Participants were 147 HIV-positive Black and Latinx MSM recruited from the mSTUDY, a cohort of 561 MSM aged 18–45 in Los Angeles, CA, of whom half are HIV-positive and substance-using. Transcriptomic measures of inflammatory and type I IFN activity were derived from RNA sequencing of peripheral blood mononuclear cells and matched to urine drug tests, VL, and survey data across two time points 12 months apart. Analysis used linear random intercept modeling of MA use, unsuppressed VL, and experienced IPV on inflammatory and type I IFN expression. Results In adjusted models, MA use predicted 27% upregulated inflammatory and 31% upregulated type I IFN expression; unsuppressed VL predicted 84% upregulated type I IFN but not inflammatory expression; and experienced IPV predicted 31% upregulated inflammatory and 26% upregulated type I IFN expression. Conclusions In Black and Latinx MSM with HIV, MA use, unsuppressed VL, and experienced IPV predicted upregulated social genomic markers of immune functioning.
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- 2021
30. Alfvén waves in the foreshock propagating upstream in the plasma rest frame: statistics from Cluster observations
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Y. Narita, K.-H. Glassmeier, S. Schäfer, U. Motschmann, M. Fränz, I. Dandouras, K.-H. Fornaçon, E. Georgescu, A. Korth, H. Rème, and I. Richter
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Science ,Physics ,QC1-999 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
We statistically study various properties of low-frequency waves such as frequencies, wave numbers, phase velocities, and polarization in the plasma rest frame in the terrestrial foreshock. Using Cluster observations the wave telescope or k-filtering is applied to investigate wave numbers and rest frame frequencies. We find that most of the foreshock waves propagate upstream along the magnetic field at phase velocity close to the Alfvén velocity. We identify that frequencies are around 0.1xΩcp and wave numbers are around 0.1xΩcp/VA, where Ωcp is the proton cyclotron frequency and VA is the Alfvén velocity. Our results confirm the conclusions drawn from ISEE observations and strongly support the existence of Alfvén waves in the foreshock.
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- 2004
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31. The Moral Necessity to Increase Access to HCV+ Transplants With Early Treatment for HCV-naive Patients
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Benjamin I Richter, Bonnie E. Lonze, and Brendan Parent
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Transplantation ,medicine.medical_specialty ,Genotype ,business.industry ,MEDLINE ,Transplants ,Hepacivirus ,Morals ,Antiviral Agents ,Hepatitis C ,Therapy naive ,Internal medicine ,Medicine ,Humans ,Sofosbuvir ,business - Published
- 2021
32. Evaluation of matrix-metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) as biomarkers for sepsis and endotoxemia in equine colic
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A Alalwani, K Purschke, I Richter, T Ahrens, Svenja Lilge, Ann-Kristin Barton, Roswitha Merle, D Barnewitz, and Heidrun Gehlen
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Sepsis ,business.industry ,Cancer research ,Medicine ,Matrix metalloproteinase ,business ,medicine.disease - Published
- 2021
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33. Tracking of magnetic helicity evolution in the inner heliosphere
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T. Alberti, Y. Narita, L. Z. Hadid, D. Heyner, A. Milillo, C. Plainaki, H.-U. Auster, and I. Richter
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Space and Planetary Science ,Astronomy and Astrophysics - Abstract
Context. Magnetic helicity is one of the invariants in ideal magnetohydrodynamics, and its spectral evolution has a substantial amount of information to reveal the mechanism that are behind turbulence in space and astrophysical plasmas. Aims. The goal of our study is to observationally characterize the magnetic helicity evolution in the inner heliosphere by resolving the helicity transport in a scale-wise fashion in the spectral domain. Methods. The evolution of the magnetic helicity spectrum in the inner heliosphere was tracked using a radial alignment event achieved by Parker Solar Probe at a distance of 0.17 astronomical units (AU) from the Sun and BepiColombo at 0.58 AU with a delay of about 3.5 days. Results. The reduced magnetic helicity resolved in the frequency domain shows three main features: (1) a coherent major peak of a highly helical component at the lowest frequency at about 5 × 10−4 Hz, (2) a damping of helicity oscillation at the intermediate frequencies from 10−3 to 10−2 Hz when observed at 0.58 AU, and (3) a coherent nonhelical component in the ion-kinetic range at frequencies of about 0.1 − 1 Hz. Conclusions. Though limited in the frequency range, the main message from this work is that the solar wind develops into turbulence by convecting large-scale helicity components on the one hand and creating and annihilating helical wave components on the other hand. Excitation of waves can overwrite the helicity profile in the inner heliosphere. By comparing this with the typical helicity spectra at a distance of 1 AU (that is, a randomly oscillating helicity sign in the intermediate frequency range up to about 1 Hz), the helicity evolution reaches a nearly asymptotic state at the Venus orbit (about 0.7 AU) and beyond.
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- 2022
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34. Multi point analysis of coronal mass ejection flux ropes using combined data from Solar Orbiter, BepiColombo and Wind
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A. J. Weiss, C. Möstl, E. E. Davies, T. Amerstorfer, M. Bauer, J. Hinterreiter, M. A. Reiss, R. L. Bailey, T. S. Horbury, H. O’Brien, V. Evans, V. Angelini, D. Heyner, I. Richter, H.-U. Auster, W. Magnes, D. Fischer, and W. Baumjohann
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Physics ,010504 meteorology & atmospheric sciences ,Flux ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,01 natural sciences ,law.invention ,Orbiter ,Astrophysics - Solar and Stellar Astrophysics ,Space and Planetary Science ,law ,0103 physical sciences ,Physics::Space Physics ,Coronal mass ejection ,Astrophysics::Solar and Stellar Astrophysics ,010303 astronomy & astrophysics ,Multi point ,Solar and Stellar Astrophysics (astro-ph.SR) ,0105 earth and related environmental sciences - Abstract
The recent launch of Solar Orbiter and BepiColombo opened a brief window in which these two spacecraft were positioned in a constellation that allows for the detailed sampling of any Earth-directed CMEs. Fortunately, two such events occurred with in situ detections of an ICME by Solar Orbiter on the 19th of April and the 28th of May 2020. These two events were subsequently also observed in situ by BepiColombo and Wind around a day later. We attempt to reconstruct the observed in situ magnetic field measurements for all three spacecraft simultaneously using an empirical magnetic flux rope model. This allows us to test the validity of our flux rope model on a larger and more global scale and allows for cross-validation of the analysis with different spacecraft combinations. Finally, we can also compare the results from the in situ modeling to remote observations obtained from the STEREO-A heliospheric imagers. We make use of the 3D coronal rope ejection model in order to simulate the ICME evolution. We adapt a previously developed ABC-SMC fitting algorithm for the application to multi point scenarios. We show that we are able to generally reconstruct the flux ropes signatures at three different spacecraft positions simultaneously using our model in combination with the flux rope fitting algorithm. For the well-behaved 19th of April ICME our approach works very well. The 28th of May ICME, on the other hand, shows the limitations of our approach. Unfortunately, the usage of multi-point observations for these events does not appear to solve inherent issues, such as the estimation of the magnetic field twist or flux rope aspect-ratios due to the specific constellation of the spacecraft positions. As our general approach can be used for any fast forward simulation-based model we give a blueprint for future studies using more advanced ICME models., Comment: 11 pages, 7 figures
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- 2021
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35. Sa1323: CLINICAL IMPACT OF PANCREATIC AND PERIPANCREATIC HEMORRHAGE ASSOCIATED WITH ACUTE PANCREATITIS
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Benjamin I. Richter, Joseph Weissbrot, Frank R. Chung, Tamas A. Gonda, and Chenchan Huang
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Hepatology ,Gastroenterology - Published
- 2022
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36. Sa1312: INCIDENCE AND PREDICTORS OF EARLY AND LATE READMISSION AFTER ACUTE PANCREATITIS
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Benjamin I. Richter, Constantine Tarabanis, Lauren G. Khanna, Gregory B. Haber, Prashant Sinha, Christopher L. Wolfgang, and Tamas A. Gonda
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Hepatology ,Gastroenterology - Published
- 2022
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37. In situ multi-spacecraft and remote imaging observations of the first CME detected by Solar Orbiter and BepiColombo
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E. E. Davies, C. Möstl, M. J. Owens, A. J. Weiss, T. Amerstorfer, J. Hinterreiter, M. Bauer, R. L. Bailey, M. A. Reiss, R. J. Forsyth, T. S. Horbury, H. O’Brien, V. Evans, V. Angelini, D. Heyner, I. Richter, H.-U. Auster, W. Magnes, W. Baumjohann, D. Fischer, D. Barnes, J. A. Davies, and R. A. Harrison
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In situ ,Physics ,010504 meteorology & atmospheric sciences ,Spacecraft ,business.industry ,FOS: Physical sciences ,Astronomy and Astrophysics ,Astrophysics ,01 natural sciences ,Space Physics (physics.space-ph) ,law.invention ,Orbiter ,Physics - Space Physics ,Astrophysics - Solar and Stellar Astrophysics ,Space and Planetary Science ,law ,0103 physical sciences ,Physics::Space Physics ,Astrophysics::Solar and Stellar Astrophysics ,Astrophysics::Earth and Planetary Astrophysics ,Aerospace engineering ,business ,010303 astronomy & astrophysics ,Solar and Stellar Astrophysics (astro-ph.SR) ,0105 earth and related environmental sciences - Abstract
Context.On 2020 April 19 a coronal mass ejection (CME) was detected in situ by Solar Orbiter at a heliocentric distance of about 0.8 AU. The CME was later observed in situ on April 20 by the Wind and BepiColombo spacecraft whilst BepiColombo was located very close to Earth. This CME presents a good opportunity for a triple radial alignment study, as the spacecraft were separated by less than 5° in longitude. The source of the CME, which was launched on April 15, was an almost entirely isolated streamer blowout. The Solar Terrestrial Relations Observatory (STEREO)-A spacecraft observed the event remotely from −75.1° longitude, which is an exceptionally well suited viewpoint for heliospheric imaging of an Earth directed CME.Aims.The configuration of the four spacecraft has provided an exceptionally clean link between remote imaging and in situ observations of the CME. We have used the in situ observations of the CME at Solar Orbiter, Wind, and BepiColombo and the remote observations of the CME at STEREO-A to determine the global shape of the CME and its evolution as it propagated through the inner heliosphere.Methods.We used three magnetic flux rope models that are based on different assumptions about the flux rope morphology to interpret the large-scale structure of the interplanetary CME (ICME). The 3DCORE model assumes an elliptical cross-section with a fixed aspect-ratio calculated by using the STEREO Heliospheric Imager (HI) observations as a constraint. The other two models are variants of the kinematically-distorted flux rope (KFR) technique, where two flux rope cross-sections are considered: one in a uniform solar wind and another in a solar-minimum-like structured solar wind. Analysis of CME evolution has been complemented by the use of (1) the ELEvoHI model to compare predicted CME arrival times and confirm the connection between the imaging and in situ observations, and (2) the PREDSTORM model, which provides an estimate of theDstindex at Earth using Solar Orbiter magnetometer data as if it were a real–time upstream solar wind monitor.Results.A clear flattening of the CME cross-section has been observed by STEREO-A, and further confirmed by comparing profiles of the flux rope models to the in situ data, where the distorted flux rope cross-section qualitatively agrees most with in situ observations of the magnetic field at Solar Orbiter. Comparing in situ observations of the magnetic field between spacecraft, we find that the dependence of the maximum (mean) magnetic field strength decreases with heliocentric distance asr−1.24 ± 0.50(r−1.12 ± 0.14), which is in disagreement with previous studies. Further assessment of the axial and poloidal magnetic field strength dependencies suggests that the expansion of the CME is likely neither self-similar nor cylindrically symmetric.
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- 2020
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38. Corrigendum to 'Ion cyclotron waves during the Rosetta approach phase: a magnetic estimate of cometary outgassing' published in Ann. Geophys., 31, 2201–2206, 2013
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M. Volwerk, C. Koenders, M. Delva, I. Richter, K. Schwingenschuh, M. S. Bentley, and K.-H. Glassmeier
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Science ,Physics ,QC1-999 ,Geophysics. Cosmic physics ,QC801-809 - Abstract
No abstract available.
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- 2013
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39. Enzalutamide and Abiraterone in the Treatment of Metastatic Castration-resistant Prostate Cancer after Chemotherapy
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I Stankuš, L Barsová, J Chalupa, V Hejzlarová, J Bartoš, M Holikova, I Richter, J Forster, M Sochor, and J Dvořák
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Male ,Oncology ,medicine.medical_specialty ,medicine.medical_treatment ,Statistical difference ,Antineoplastic Agents ,Castration resistant ,chemistry.chemical_compound ,Prostate cancer ,Internal medicine ,Nitriles ,Phenylthiohydantoin ,medicine ,Humans ,Enzalutamide ,In patient ,Neoplasm Metastasis ,Aged ,Retrospective Studies ,Aged, 80 and over ,Chemotherapy ,business.industry ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Prostatic Neoplasms, Castration-Resistant ,Abiraterone ,chemistry ,Benzamides ,Androstenes ,business - Abstract
Aim Enzalutamide and abiraterone represent new therapeutical options in the treatment of metastatic castration-resistant prostate cancer (mCRPC). The aim of the presented study was retrospective analysis of clinical experience and efficacy of enzalutamide or abiraterone in the postchemo indication in patients with mCRPC. Patients and methods A total of 32 mCRPC patients were evaluated. All patients received one or more lines of chemotherapy. Twenty-three patients were treated by enzalutamide, nine patients were treated by abiraterone. We defined two parameters: over all survival and progression-free survival. Results The median follow-up was 6.5 months. A total of 10 patients treated by enzalutamide progressed (43.47%) and eight patients died (34.78%). A total of five patients treated by abiraterone progressed (55.56%) and one patient died (11.11%). We did not observe any statistical difference in over all survival (HR 0.2362, 95% CI 0.0295- 1.8942; p = 0.102) and in progression-free survival (HR 0.9853, 95% CI 0.2934- 3.308; p = 0.939) between enzalutamide and abirateron. Conclusion Our retrospective study demonstrated similar efficacy of enzalutamide and abiraterone in mCRPC patients previously treated by chemotherapy.
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- 2016
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40. 1548P Favourable prognostic significance of membranous β-catenin expression and negative prognostic significance of cytoplasmic β-catenin expression in pancreatic cancer
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Josef Dvorak, I. Richter, P. Szabo, Alžběta Filipová, Blanka Rosova, Tomas Buchler, Jan Proks, D. Hadzi Nikolov, Bohuslav Melichar, Renata Chloupková, R. Matej, and Aneta Rozsypalova
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0303 health sciences ,business.industry ,Hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,Cytoplasm ,030220 oncology & carcinogenesis ,Pancreatic cancer ,Catenin ,Cancer research ,Medicine ,business ,030304 developmental biology - Published
- 2020
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41. A comparison between VEGA 1, 2 and Giotto flybys of comet 1P/Halley: implications for Rosetta
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M. Volwerk, K.-H. Glassmeier, M. Delva, D. Schmid, C. Koenders, I. Richter, and K. Szegö
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lcsh:Geophysics. Cosmic physics ,lcsh:QC801-809 ,lcsh:Q ,lcsh:Science ,lcsh:Physics ,lcsh:QC1-999 - Abstract
Three flybys of comet 1P/Halley, by VEGA 1, 2 and Giotto, are investigated with respect to the occurrence of mirror mode waves in the cometosheath and field line draping in the magnetic pile-up region around the nucleus. The time interval covered by these flybys is approximately 8 days, which is also the approximate length of an orbit or flyby of Rosetta around comet 67P/Churyumov–Gerasimenko. Thus any significant changes observed around Halley are changes that might occur for Rosetta during one pass of 67P/CG. It is found that the occurrence of mirror mode waves in the cometosheath is strongly influenced by the dynamical pressure of the solar wind and the outgassing rate of the comet. Field line draping happens in the magnetic pile-up region. Changes in nested draping regions (i.e. regions with different Bx directions) can occur within a few days, possibly influenced by changes in the outgassing rate of the comet and thereby the conductivity of the cometary ionosphere.
- Published
- 2018
42. In vitro fermentation of nuts results in the formation of butyrate and c9,t11 conjugated linoleic acid as chemopreventive metabolites
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Carsten Rohrer, I Richter, Wiebke Schlörmann, Alfred Lochner, Michael Glei, Marc Birringer, and Stefan Lorkowski
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0301 basic medicine ,Conjugated linoleic acid ,Medicine (miscellaneous) ,Vaccenic acid ,Juglans ,Oleic Acids ,Butyrate ,Thiobarbituric Acid Reactive Substances ,Bile Acids and Salts ,Lipid peroxidation ,Feces ,03 medical and health sciences ,chemistry.chemical_compound ,Corylus ,Malondialdehyde ,Humans ,Nuts ,Linoleic Acids, Conjugated ,Food science ,Fatty acid methyl ester ,chemistry.chemical_classification ,030109 nutrition & dietetics ,Nutrition and Dietetics ,food and beverages ,Hydrogen-Ion Concentration ,Prunus dulcis ,Gastrointestinal Microbiome ,Butyrates ,chemistry ,Biochemistry ,Macadamia ,Colonic Neoplasms ,Fermentation ,Pistacia ,Fatty Acids, Unsaturated ,Polyunsaturated fatty acid - Abstract
The consumption of foods rich in dietary fiber and polyunsaturated fatty acids such as nuts can contribute to a healthy diet. Therefore, the formation of fermentation end-products which might exert chemopreventive effects regarding colon cancer was investigated after an in vitro simulated digestion and fermentation of nuts using human fecal microbiota. Fermentation supernatants (FS) and pellets (FP) were obtained after an in vitro fermentation of hazelnuts, almonds, macadamia, pistachios and walnuts. Short-chain fatty acids (SCFA) and bile acids (BA) in FS as well as fatty acids in FP were analyzed via gas chromatography. Malondialdehyde (MDA) levels in FS were determined photometrically. Fermentation of nuts resulted in 1.9- to 2.8-fold higher concentrations of SCFA compared to the control and a shift of molar ratios toward butyrate production. In vitro fermentation resulted in the formation of vaccenic acid (C18:1t11, 32.1 ± 3.2 % FAME; fatty acid methyl ester) and conjugated linoleic acid (c9,t11 CLA, 2.4 ± 0.7 % FAME) exclusively in fermented walnut samples. Concentrations of secondary BA deoxycholic-/iso-deoxycholic acid (6.8–24.1-fold/4.9–10.9-fold, respectively) and levels of MDA (1.3-fold) were significantly reduced in fermented nut samples compared to the control. This is the first study that demonstrates the ability of the human fecal microbiota to convert polyunsaturated fatty acids from walnuts to c9,t11 CLA as a potential chemopreventive metabolite. In addition, the production of butyrate and reduction in potential carcinogens such as secondary BA and lipid peroxidation products might contribute to the protective effects of nuts regarding colon cancer development.
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- 2015
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43. Primary cilia in gastrointestinal stromal tumors
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I. Richter, Stanislav Filip, Bohuslav Melichar, Jaroslav Mokry, D. Hadzi Nikolov, Josef Dvorak, Alžběta Filipová, Veronika Sitorová, Jiří Petera, David Buka, and Ales Ryska
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Adult ,Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Stromal cell ,Gastrointestinal Stromal Tumors ,Metastasis ,medicine ,Humans ,Cilia ,neoplasms ,Aged ,Gastrointestinal Neoplasms ,GiST ,business.industry ,Cilium ,Imatinib ,Middle Aged ,medicine.disease ,Primary tumor ,digestive system diseases ,Oncology ,Centrosome ,Monoclonal ,Female ,business ,medicine.drug - Abstract
The primary cilium is a solitary, sensory, non-motile microtubule-based structure that arises from the centrosome and is projected from the surface of most human cells. The objective of the current pilot study was to conduct an investigation of presence and frequency of cilia in gastrointestinal stromal tumors (GIST).The presence of primary cilia in GIST was evaluated in 9 patients, including 8 primary tumors and 1 liver metastasis. In 2 patients the presence of primary cilia was evaluated not only in the primary tumor, but also in recurrence: in 1 patient in recurrence without previous treatment with imatinib and in 1 patient in recurrence after treatment with imatinib. The primary cilia of GIST cells were immunofluorescently stained with primary monoclonal anti-acetylated tubulin alpha antibody and cell nuclei with DAPI.We observed 9985 nuclei of cells of GISTs and 425 primary cilia in total. The median of frequency of primary cilia in cells of GISTs in all examined samples was 4.26%, in primary tumors was 4.32% and in metastases was 3.64%, respectively. This pilot study provides the evidence of the presence of primary cilia in GISTs in different organs. Primary cilia were identified in all examined cases of GIST, including primary tumors, metastases and recurrent lesions without and with previous treatment with imatinib.
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- 2014
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44. The Magnetospheric Multiscale Magnetometers
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C. T. Russell, B. J. Anderson, W. Baumjohann, K. R. Bromund, D. Dearborn, D. Fischer, G. Le, H. K. Leinweber, D. Leneman, W. Magnes, J. D. Means, M. B. Moldwin, R. Nakamura, D. Pierce, F. Plaschke, K. M. Rowe, J. A. Slavin, R. J. Strangeway, R. Torbert, C. Hagen, I. Jernej, A. Valavanoglou, and I. Richter
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010302 applied physics ,010309 optics ,0103 physical sciences ,01 natural sciences - Published
- 2016
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45. P-005Prognostic significance of the frequency of primary cilia in cells of small bowel and colorectal adenocarcinoma
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Bohuslav Melichar, Tomas Buchler, I. Richter, Jaroslav Mokry, Alzbeta Filipova, David Buka, Josef Dvorak, Jitka Abrahámová, Stanislav Filip, Ales Ryska, D. Hadzi Nikolov, M. Kupec, and Ladislav Dušek
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Pathology ,medicine.medical_specialty ,Colorectal cancer ,Cell ,Gastroenterology ,03 medical and health sciences ,Abstracts ,0302 clinical medicine ,Microtubule ,Internal medicine ,medicine ,030304 developmental biology ,0303 health sciences ,biology ,business.industry ,Cilium ,Cancer ,Hematology ,medicine.disease ,3. Good health ,medicine.anatomical_structure ,Oncology ,Centrosome ,030220 oncology & carcinogenesis ,Monoclonal ,biology.protein ,Antibody ,business - Abstract
Purpose: The primary cilium is a solitary, sensory, immotile microtubule-based structure that arises from the centrosome and is projected from the surface of most human cell types. It has been hypothesized that primary cilia could serve as a tumor suppressor organelle. The objective of this pilot study was to investigate the presence and frequency of primary cilia in cells of small bowel and colorectal adenocarcinoma and to evaluate the prognostic significance of their frequency. Methods: The presence of primary cilia in cells in samples of small bowel (8 patients) and colorectal adenocarcinoma (32 patiens) was evaluated. The primary cilia of cells were immunofluorescently labeled using primary monoclonal anti-acetylated alpha-tubulin antibody and cell nuclei were labeled using DAPI. Results: Primary cilia were identified in all examined specimens. The median frequency of primary cilia was 0.49% in cells of small bowel cancer and 0.22% in cells in colorectal cancer. Overall survival according to frequency of primary cilia in all intestinal adenocarcinomas was significantly longer in patients with higher frequency (>= 0.187) than in patients with lower frequency of primary cilia ( = 0.187) than in patients with lower frequency of primary cilia (< 0.187) (p=0.028). Conclusions: The present pilot study provides the first evidence of the prognostic significance of the frequency of primary cilia in small bowel and colorectal adenocarcinoma. Because of significantly higher median frequency of primary cilia in the rare small bowel adenocarcinoma than in the frequent colorectal adenocarcinoma (p
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- 2016
46. The frequency of primary cilia, CD8+ tumor infiltrating lymphocytes and PD-1 expression in renal cell carcinoma of clear-cell type
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Roman Zachoval, Tomas Buchler, Alžběta Filipová, R. Matej, Jan Proks, Ladislav Dušek, I. Richter, Bohuslav Melichar, Josef Dvorak, Aneta Rozsypalova, Blanka Rosova, and D. Hadzi Nikolov
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0303 health sciences ,Tumor-infiltrating lymphocytes ,business.industry ,Cilium ,Hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Oncology ,Renal cell carcinoma ,030220 oncology & carcinogenesis ,Cancer research ,Medicine ,business ,Clear cell type ,CD8 ,030304 developmental biology - Published
- 2018
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47. Fourier Series-Based Bidirectional Propagation Algorithm With Adaptive Spatial Resolution
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J. Ctyroky, P Kwiecien, and I Richter
- Subjects
Eigenmode expansion ,Coordinate system ,Physics::Optics ,Optical field ,Adaptive optics ,Rigorous coupled-wave analysis ,Series expansion ,Fourier series ,Waveguide (optics) ,Algorithm ,Atomic and Molecular Physics, and Optics ,Mathematics - Abstract
Recently we described the implementation of complex coordinate transformation as boundary conditions into a bidirectional eigenmode expansion propagation algorithm based on Fourier series expansion for modeling optical field distribution in waveguide devices. In this communication we report on the implementation of an additional coordinate transformation known as adaptive spatial resolution into this algorithm. It helps significantly reduce the number of expansion terms needed to reach required accuracy especially for photonics structures containing layers of very different thicknesses and/or optical properties, e.g., metal layers.
- Published
- 2010
- Full Text
- View/download PDF
48. Characterization of a bone biorepository: Comparison of bone metastases from breast, prostate, renal, lung cancers, and myeloma
- Author
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Alessandro Fatatis, Kerith Wang, Benjamin E. Leiby, William Kevin Kelly, Lucia R. Languino, Peter McCue, John Abraham, Raymond O'Neill, Jianhong Li, Benjamin I. Richter, Karen M. Bussard, and Matthew J. Schiewer
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Lung ,business.industry ,Cancer ,medicine.disease ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Biorepository ,medicine.anatomical_structure ,Prostate ,Internal medicine ,medicine ,030212 general & internal medicine ,business - Abstract
e24019Background: While bone is one of the most common sites of metastasis for many cancer types, lack of access to the necessary quantity and quality of human specimens limits the understanding of...
- Published
- 2018
- Full Text
- View/download PDF
49. S86. Vesicular Monoamine Transporter (VMAT2) Binding in Platelets as a Biomarker for Severity of Major Depressive Disorder
- Author
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Anthony Tucker Valdes, Megan L. Fitzgerald, Maria A. Oquendo, Licínia Ganança, M. Elizabeth Sublette, Adrienne Hezghia, Hanga Galfalvy, J. John Mann, Benjamin I. Richter, and Yolanda Mara Zafrina
- Subjects
Vesicular monoamine transporter ,business.industry ,medicine ,Major depressive disorder ,Biomarker (medicine) ,Platelet ,Pharmacology ,medicine.disease ,business ,Biological Psychiatry - Published
- 2018
- Full Text
- View/download PDF
50. Plastisch-chirurgische Versorgung des fortgeschrittenen Mammakarzinoms
- Author
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M Schmiel, A. M. Feller, I. Richter-Heine, and C Heitmann
- Subjects
business.industry ,Maternity and Midwifery ,Obstetrics and Gynecology ,Medicine ,business - Published
- 2010
- Full Text
- View/download PDF
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