Author: "I. Banu" - Searchworks@Jio Institute Digital Library Search Results

92 results on '"I. Banu"'

1. A Kinetic Study of Methyl-Isobutyl Ketone Catalytic Combustion on LDH-Derived Cobalt Containing Mixed Oxides

Author: I. Banu, I. Popescu, I.C. Marcu, and G. Bozga
Subjects: Chemical engineering, TP155-156, Computer engineering. Computer hardware, TK7885-7895
Abstract: A Co-MgAlO mixed oxide with 20 at % Co obtained from a layered double hydroxide (LDH) precursor was synthesized and its activity has been studied in the catalytic combustion of the methyl isobutyl ketone (MIBK). The characterization of the catalyst was performed by XRD, EDX and nitrogen adsorption. Its catalytic activity was evaluated in a fixed-bed continuous flow reactor in operating conditions typical for depollution applications, in the temperature range 100 - 400 °C and compared with MgAlO free of Co support and Co3O4. A reasonable good activity for the synthesized material at relatively low temperature was found. The catalyst was further subjected to a kinetic study in order to identify the temperature and composition dependencies of the combustion rate.
Published: 2015
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2. Betaboltz: A Monte-Carlo simulation tool for gas scattering processes.

Author: Michele Renda, D. A. Ciubotaru, and C. I. Banu
Published: 2021
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3. A Case of Late-Detected Pheochromocytoma in a Young Patient With Resistant Hypertension and Hypertrophic Cardiomyopathy

Author: A. Voican, I. Banu, Martin Brenier, Ahmad Alamri, Adrien Ben Hamou, Constance Oriez, Jean-Jacques Mourad, and Olivier Dupuy
Subjects: Pheochromocytoma, medicine.medical_specialty, business.industry, Internal medicine, Internal Medicine, medicine, MEDLINE, Resistant hypertension, Hypertrophic cardiomyopathy, Cardiology, medicine.disease, business
Published: 2020

4. The impact of regular exercise in physiological regulation: mini review.

Author: Oral, Onur, Tatlibal, Pınar, Ayca, I. Banu, and Tatlibal, Cemil
Subjects: EXERCISE physiology, LIFESTYLES & health, PHYSICAL activity
Abstract: With a better understanding of the importance and necessity of physical activity for health all over the world, a more active lifestyle and regular exercise have been adopted by large masses of people. And thus the habit of regular exercise has been one of the important reasons for reducing the incidence of chronic diseases such as obesity, cardiovascular diseases, hypertension, diabetes, depression, and osteoporosis. It is everyone's dream to be healthy and fit throughout life. In line with this goal, many factors can be mentioned in life to maintain health and be healthier, but among all these factors, adequate and balanced nutrition and regular physical activity habits are of great importance for a healthy life. Along with adequate and balanced nutrition, exercise is critical to the proper functioning of the body and the prevention and treatment of obesity. Exercise is important for the development of muscle mass and the healthy functioning of the cardiovascular (heart and vascular) system. However, being physically active and maintaining regular exercise habits as a way of life is also important for the protection and development of health. [ABSTRACT FROM AUTHOR]
Published: 2023

5. Une iatrogénie méconnue des antithyroïdiens de synthèse : la pancréatite aiguë

Author: Olivier Dupuy, Adrien Ben Hamou, and I. Banu
Subjects: Gynecology, medicine.medical_specialty, business.industry, MEDLINE, Medicine, General Medicine, business
Published: 2019

6. Première expérience de boucle fermée en vie réelle

Author: L. Jolie, A. Voican, F. Bouilloud, I. Banu, C. Baudry, I. Revue, and Olivier Dupuy
Subjects: Endocrinology, Endocrinology, Diabetes and Metabolism, General Medicine
Abstract: Introduction Malgre l’investissement continu des diabetiques de type 1, l’equilibre glycemique est parfois loin des objectifs avec des resultats aleatoires. La boucle fermee a deja prouve ses benefices dans des etudes et la prise en charge est attendue prochainement. Population et methodes Nous avons equipe 5 patients diabetiques de type 1 avec la pompe Minimed 780G couplee au capteur Guardian Sensor 3 en boucle fermee (Smartguard) : 4 hommes et 1 femme traites par pompe a insuline depuis au moins 5 ans, dont un avec une pompe patch. La moyenne d’âge etait de 45,8 ans, la duree de diabete de 22,8 ans. L’indication principale de la boucle fermee concernait la frequence des hypoglycemies, severes ou repetees. L’activation du Smartguard a ete faite lors d’une hospitalisation de semaine, avec une education repetee au comptage des glucides. Un suivi par consultations telephoniques a ete mis en place toutes les 2 semaines puis mensuel. Resultats A l’inclusion l’HbA1c etait comprise entre 6,3 % et 8,5 %, la duree dans la cible (free style libre) entre 30 % et 70 %, le temps passe Discussion Ces resultats a court terme sont rassurants et necessitent une validation sur le long terme. La charge mentale semble etre moindre.
Published: 2021

7. Un diabète d’équilibre difficile

Author: Olivier Dupuy, I. Banu, A. Voican, O. Plesa, and Constance Oriez
Subjects: Endocrinology, Endocrinology, Diabetes and Metabolism, General Medicine
Abstract: Observation Un patient de 45 ans, hospitalise en urologie pour des coliques nephretiques recidivantes avec pose de sonde JJ est transfere pour desequilibre de son diabete avec alternance hypo-hyperglycemies. Il presente un syndrome de Fanconi Bickel associant glycogenose avec intolerance aux galactosidases, tubulopathie proximale complete, osteopathie avec rachitisme Vitamino resistant et multiples fractures, nanisme (1,55 m pour 45 kg) par deficit partiel en GH. Le diabete, diagnostique en 2005 est lie a une mutation homozygote de Glut 2. En raison de regles hygieno-dietetiques peu respectees, une insulinotherapie associant basale et bolus a ete initiee en 2010 puis relayee par sulfamides hypoglycemiants seuls. La frequence des hypoglycemies nocturnes conduit le patient a l’arret de tout traitement. A son entree l’HbA1C atteint 9 %. Apres de multiples essais therapeutiques, l’association d’insuline detemir le matin a faible dose et de metformine-embomate 700 en trois prises permet d’obtenir un equilibre satisfaisant sans hypoglycemie. Discussion . Les dysglycemies observees chez les patients avec syndrome de Fanconi Bickel associent hyperglycemies postprandiales, hypoglycemies nocturnes et/ou intolerance au glucose ; la frequence du diabete de type II est bien plus rare dans ce syndrome. Les anomalies des co-transporteurs Glucose Sodium du tube contourne proximal (SGLT) dans cette pathologie ont vraisemblablement un effet protecteur.
Published: 2021

8. Author response for 'Asymptomatic left ventricular dysfunction in type 2 diabetic patients free of cardio vascular disease and relationship with clinical characteristics: The <scp>DIACAR</scp> cohort study'

Author: Gilles Chatellier, Philippe Abassade, I. Banu, Michel Komajda, Maxime Fumery, A. Voican, Romain Cador, Yoann Moeuf, Constance Oriez, Philippe Garçon, Olivier Dupuy, Yara Antakly Hanon, and Adrien Ben Hamou
Subjects: Cardio vascular disease, medicine.medical_specialty, business.industry, Internal medicine, medicine, Cardiology, medicine.symptom, business, Asymptomatic, Cohort study
Published: 2020

9. Asymptomatic left ventricular dysfunction in patients with type 2 diabetes free of cardiovascular disease and its relationship with clinical characteristics: The DIACAR cohort study

Author: Romain Cador, Yoann Moeuf, I. Banu, Philippe Abassade, Adrien Ben Hamou, Constance Oriez, Yara Antakly-Hanon, Maxime Fumery, A. Voican, Philippe Garçon, Olivier Dupuy, Michel Komajda, and Gilles Chatellier
Subjects: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Asymptomatic, Ventricular Function, Left, Cohort Studies, 03 medical and health sciences, Ventricular Dysfunction, Left, 0302 clinical medicine, Endocrinology, Internal medicine, Internal Medicine, Medicine, Humans, Univariate analysis, Ejection fraction, business.industry, Type 2 Diabetes Mellitus, medicine.disease, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Heart failure, Cardiology, Female, medicine.symptom, business, Body mass index, Cohort study
Abstract: Aims Type 2 diabetes mellitus (T2DM) is associated with high risk of heart failure. Several studies have reported asymptomatic left ventricular dysfunction (LVD) in T2DM patients with normal ejection fraction. Purpose of our study was to assess the prevalence, the type and clinical factors associated with LVD in T2DM patients by a comprehensive echocardiographic Doppler assessment including speckle tracking. Methods 200 T2DM patients without overt cardio-vascular disease were prospectively enrolled in a single center cohort study between 2018 and 2019. Results LV mass was increased in 24 patients (12%) whereas relative wall thickness (h/r) was increased in 46 patients (23%). Left atrial (LA) enlargement was observed in 27 patients (13.6%) and global longitudinal strain (GLS) was reduced in 38 patients (20.3%). By univariate analysis, LV hypertrophy or increased h/r were associated with age, renal function, hypertension and B type natriuretic peptide plasma level (BNP). LA dilation was associated with age, history of hypertension, diabetes duration and complications, insulin treatment, BNP and renal function. GLS was associated with body mass index (BMI) and in a borderline manner with diabetes duration. By multivariate analysis, hypertension was associated with LVH, and with h/r and a borderline relationship was observed for female gender (LVH) age and insulin treatment (h/r). Age, hypertension and in a borderline manner insulin treatment were associated with LA dilation. BMI and shorter diabetes duration were associated with reduced GLS. Conclusion/interpretation A high prevalence of asymptomatic cardiac dysfunction/structural abnormalities is observed in T2DM without overt cardiac disease and is associated with either age, diabetes duration or treatment and with comorbidities including hypertension and obesity. Whether these preclinical abnormalities are associated with poor outcomes deserves further studies. This article is protected by copyright. All rights reserved.
Published: 2020

10. Néphropathie inhabituelle dans le cadre d’un diabète de type 1

Author: A. Voican, Olivier Dupuy, M. Touzot, M. Borrely, A. Ben Hamou, I. Banu, and Constance Oriez
Subjects: Endocrinology, Endocrinology, Diabetes and Metabolism, General Medicine
Abstract: Observation Une patiente, diabetique de type I nee âgee de 51 ans, est hospitalisee pour syndrome nephrotique. Elle a pour antecedents : une maladie de Crohn depuis 30 ans stable, une thyroidite, une cardiomyopathie dilatee avec FEVG evaluee a 56 %. Le diabete de type I est apparu en novembre 2015 avec acidocetose inaugurale (pH 7,24 cetonemie 7 mmol/L anticorps anti-GAD a 430 mUI N Elle presente une poussee de syndrome nephrotique impur en mai 2020 avec PBR le 25/06/2020 qui revele une glomerulonephrite extra-membraneuse (GNEM). L’examen en IF montre des depots d’IgG4. En parallele, l’apparition de douleurs cervicales sur une thyroide tres dure a la palpation entraine une chirurgie en octobre dont l’histologie confirme le diagnostic de thyroidite de Riedel avec depots d’IgG4. Un traitement associant corticotherapie et immunotherapie est en cours. Discussion Les maladies systemiques associees aux IgG4 sont rares, le premier cas a ete publie en 1961. Les pathologies les plus souvent associees sont la pancreatite auto-immune, la cholangite sclerosante, la sialadenite, ou la nephrite interstitielle ou GNEM comme chez notre patiente. La thyroidite de Riedel est un organe cible de ces immunoglobulines. Le diagnostic a ete confirme par la biopsie renale et l’anatomopathologie de la thyroidite avec infiltrat riche en plasmocytes IgG 4. La singularite de cette observation resulte dans l’association au diabete de type 1, et a la cardiomyopathie elle aussi auto-immune (Ac anti-B2 adrenergique+). Ces anomalies pourraient rentrer dans le cadre d’une PEAI non decrite a ce jour.
Published: 2021

11. Systematic echo-doppler screening identifies subtle structural and functional cardiac abnormalities in type 2 diabetes mellitus without documented cardio vascular disease: DIACAR a prospective study

Author: M. Rovani, V. Boileve, Olivier Dupuy, Maxime Fumery, A. Voican, Romain Cador, Philippe Garçon, I. Banu, Philippe Abassade, Y. Antakly, A. Ben Hamou, Michel Komajda, and M.J. Aroulanda
Subjects: Cardiac function curve, medicine.medical_specialty, education.field_of_study, Ejection fraction, business.industry, Population, Type 2 Diabetes Mellitus, medicine.disease, Asymptomatic, Internal medicine, Heart failure, medicine, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Prospective cohort study, education, Body mass index
Abstract: Background Type 2 diabetes mellitus (DM2) is associated with a high prevalence of cardio vascular (CV) disorders including heart failure. The prevalence of asymptomatic cardiac dysfunction in DM2 remains poorly documented in patients without a history of cardio vascular disease. The purpose of DIACAR is to characterize cardiac function by doppler-echocardiography in a population of DM2 without documented CV disease. Methods One hundred and sixteen consecutive outpatients (63 males, 53 females) with DM2 were evaluated prospectively in a single center: 2D (Simpson biplane) & 3D (Heart Model Philips) left ventricular (LV) ejection fraction (EF), LV and left atrial (LA) volumes, 2D global longitudinal strain, diastolic function and LV mass index were measured. All patients with a documented history of CV disease or presenting with symptoms suggestive of any cardiac disorder were excluded. Results Patients were 57.8 ± 10.9 years old and had a history of DM2 of 12.7 ± 8.7 years. Fifty-two patients (45%) were treated with insulin. Body mass index was 29 ± 4.9 kg/m2. Mean values of the echo Doppler parameters were in the normal range ( Table 1 ). 2D Simpson EF and E/e’ were normal in all except one and two patients respectively. However, LV mass index was increased in 8/63 men and 10/53 women and LA volume index was increased in 14/116 patients whereas 2D Simpson LV volumes were all in the normal range. Finally, 2D global longitudinal strain was reduced in 44/105 patients. Conclusion In a selected population of DM2 without documented CV disease, cardiac function assessed by EF and E/e’ was in the normal range in nearly all patients. By contrast, subtle abnormalities of LV and LA morphology as well as 2D global longitudinal strain were found in a significant proportion of these asymptomatic patients. These results suggest that a systematic screening of DM2 patients by doppler- echocardiography with 2D global longitudinal strain is useful for the early detection of cardiac abnormalities.
Published: 2020

12. Collaborateurs de la présente édition

Author: N. Nabholz, C. Ciangura, M. Morena, R. Roussel, J.-L. Richard, A. Grimaldi, C. Colette, J.-P. Cristol, I. Banu, G. Lagger, B. Canaud, P. Valensi, G. Ha Van, J.-J. Robert, A. Wojtusciszyn, O. Dupuy, L. Monnier, S. Chiheb, F. Bonnet, S. Jacqueminet, A. Golay, A. Scheen, H. Leray-Moragues, E. Renard, E. Bousquet, C. Brunet, M. Chambouleyron, A. El Azrak, S. Schuldiner, M. Baudot, A. Fontbonne, L. Bordier, M. Marre, F. Galtier, E. Cosson, C. Sachon, J. Bringer, A. Lasserre-Moutet, C. Serny, A. Giordan, B. Vialettes, B. Vergès, J.-L. Schlienger, A. Hartemann, I. Aubry, F. Travert, S. Halimi, M. Piperno, D. Rochd, B. Bauduceau, J.-F. Blicklé, and P.-J. Guillausseau
Published: 2019

13. Collaborateurs de la précédente édition

Author: G. Ha Van, A. Hartemann, Paul Valensi, I. Aubry-Quénet, S. Chiheb, H. Mayaudon, P J Guillausseau, C. Sachon, A. Grimaldi, L. Bordier, M. Baudot, H. Leray-Moragues, André Giordan, B. Vialettes, S. Renaud, B. Canaud, L. Monnier, F. Galtier, S. Schuldiner, J.-J. Robert, M. Halbron, Jean-Louis Schlienger, R. Roussel, A. Lasserre Moutet, Grégoire Lagger, O. Dupuy, Alain Golay, B. Vergès, A. Fontbonne, C. Brunet, C. Ciangura, J. Bringer, S. Halimi, S. Allieu-Amara, J.-L. Richard, I. Banu, J.-F. Blickle, E. Cosson, E. Bousquet, M. Marre, L. Chenine, Monique Chambouleyron, F. Travert, É. Renard, C. Colette, M. Piperno, E. Lecornet-Sokol, S. Jacqueminet, A. Wojtusciszyn, and B. Bauduceau
Published: 2019

14. Orbitopathie basedowienne sévère : un cas d’hémangiome frontal

Author: Olivier Dupuy, Ahmad Alamri, Constance Oriez, Daphné Pauchet, André Balaton, A. Ben Hamou, I. Banu, and A. Voican
Subjects: Endocrinology, Endocrinology, Diabetes and Metabolism, General Medicine
Abstract: La maladie de Basedow touche 1,5 % de la population. L’une de ses manifestations les plus courantes est l’orbitopathie basedowienne (OB), qui peut etre severe, necessitant un traitement par bolus de glucocorticoides par voie intraveineuse (GC IV) comme recommande par le groupe europeen de l’orbitopathie basedowienne « European Group of Grave's Orbitopathy » (EUGOGO). Les hemangiomes osseux sont des tumeurs benignes extremement rares dont l’origine n’est pas encore bien determinee. Nous decrivons le cas d’une femme de 41 ans, qui presentait une thyreotoxicose severe difficile a controler par antithyroidiens de synthese (ATS), et qui etait associee a une OB severe sans neuropathie optique. Elle a beneficie d’une dose totale de 7,5 grammes de GC IV sur dix semaines puis d’une thyroidectomie totale. Au cours de la premiere consultation de suivi, la patiente avait rapporte la survenue d’une depression osseuse frontale. L’imagerie (TDM et IRM) a montre une lesion lytique de l’os frontal. Une biopsie osseuse a ete realisee montrant un hemangiome de l’os frontal. A notre connaissance, aucun cas n’a ete rapporte dans la litterature et aucun lien causal n’a ete precedemment identifie. Les hypotheses les plus probables pouvant expliquer la survenue de cette tumeur sont possiblement : – bolus GC IV pouvant alterer l’endothelium vasculaire, entrainant des perturbations circulatoires ; pouvant egalement etre responsable de la majoration de la resorption osseuse par activation osteoclastique ; – l’hyperthyroidie majeure et prolongee a pu contribuer a la survenue d’une telle lesion. Un traitement a visee esthetique par autogreffe de tissu adipeux a ete realise avec succes.
Published: 2020

15. Un cas de phéochromocytome de découverte tardive chez une jeune patiente ayant une hypertension artérielle résistante avec une cardiomyopathie hypertrophique

Author: Martin Brenier, Ahmad Alamri, A. Voican, Olivier Dupuy, I. Banu, Constance Oriez, and A. Ben Hamou
Subjects: Endocrinology, Endocrinology, Diabetes and Metabolism, General Medicine
Abstract: L’hypertension arterielle (HTA) est la maladie chronique la plus frequente chez l’adulte avec une prevalence estimee a 30 %. Cette pathologie augmente le risque de complications cardiovasculaires. Cinq a 15 % de ces patients ont une hypertension secondaire. Si cette cause est identifiee et traitee, l’HTA peut etre resolue et les complications peuvent-etre evitees. Une HTA resistante chez un sujet jeune, ayant un retentissement qui a possiblement un lien avec l’HTA est un argument pour l’explorer et rechercher une HTA secondaire. Nous rapportons un cas inhabituel de retard diagnostic de plus de trois ans d’un volumineux pheochromocytome de 11 centimetres, chez une jeune patiente, suivie entre 2016 et 2019 pour une hypertension arterielle resistante sous pentatherapie et une cardiomyopathie hypertrophique. Apres exploration hormonale, morphologique (TDM, IRM) et radiometabolique (TEP-FDG et MIBG), la masse surrenalienne envahissait l’artere renale et la veine cave inferieure, ayant conduit a une nephrectomie avec realisation d’une cavectomie inferieure et la pose d’une prothese cave. Le cas decrit met en lumiere le retard de diagnostic dans le cadre d’un pheochromocytome, ayant conduit a un geste chirurgical complexe, qui aurait probablement pu etre evite si le diagnostic avait ete evoque precocement.
Published: 2020

16. Are Obese Individuals with no Feature of Metabolic Syndrome but Increased Waist Circumference Really Healthy? A Cross Sectional Study

Author: Paul Valensi, M. T. Nguyen, E. Hamo-Tchatchouang, Emmanuel Cosson, S. Chiheb, C. Cussac-Pillegand, I. Banu, Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA), and Merck Lipha sante(R), Lyon, France
Subjects: Adult, Male, medicine.medical_specialty, Waist, microalbuminuria, [SDV]Life Sciences [q-bio], Endocrinology, Diabetes and Metabolism, Population, fatty liver index, 030232 urology & nephrology, Physiology, 030209 endocrinology & metabolism, oral glucose tolerance test, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin resistance, Internal medicine, Diabetes mellitus, Metabolically healthy obesity, Internal Medicine, medicine, Humans, Obesity, education, 2. Zero hunger, Metabolic Syndrome, education.field_of_study, business.industry, General Medicine, Middle Aged, medicine.disease, 3. Good health, arterial stiffness, Cross-Sectional Studies, metabolically healthy obesity, Microalbuminuria, Female, Metabolic syndrome, Waist Circumference, cardiac autonomic dysfunction, business, Body mass index
Abstract: International audience; Aim: Patients displaying the metabolically healthy but obese phenotype have an intermediate cardiometabolic prognosis compared to normal weight healthy and metabolically unhealthy obese subjects. We aimed to evaluate the proportion of patients with a definite metabolically healthy obese phenotype and better characterize them. Methods: Definite metabolically healthy obese phenotype was defined as having none of the International Diabetes Federation metabolic syndrome criteria, excluding waist circumference. We recruited 1 159 obese patients (body mass index 38.4 +/- 6.3 kg/m(2)) including 943 women, without known diabetes. Patients were characterized for cardiometabolic disorders. Results: As the 202 (17.4 %) metabolically healthy obese individuals were younger and had lower body mass indexes than the 957 metabolically unhealthy obese patients, they were matched for gender, age and body mass index with 404 metabolically unhealthy obese patients. In addition to the features of metabolic syndrome, when compared to unhealthy subjects, definite metabolically healthy obese patients were less frequently found with either homeostasis model assessment of insulin resistance index >3 (23.6 vs. 38.9 %, p < 0.001), or abnormal oral glucose tolerance test (13.9 vs. 33.9 %, p < 0.001), or HbA1c value >= 5.7 % (43.9 vs. 54.2 %, p < 0.05) or pulse pressure >= 60 mmHg (11.7 vs. 64.9 %, p < 0.001). However, there were no significant differences in the prevalence of microalbuminuria (11.1 vs. 12.3 %), cardiac autonomic dysfunction (45.5 vs. 35.3 %) and fatty liver index >= 60 (5.6 vs. 10.2 %). Conclusion: Our data do not support the characterization of metabolically healthy obesity, even definite, as really healthy, as many patients with this phenotype have abnormal cardiovascular markers and glucose or liver abnormalities. HbA1c measurement seems to be more sensitive than OGTT to detect dysglycemia in this population.
Published: 2016

17. Hypoglycémie et effets cardiovasculaires

Author: I. Banu and P. Valensi
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine, Cardiology and Cardiovascular Medicine
Abstract: La survenue d’hypoglycemies est pratiquement inevitable lorsqu’un equilibre glycemique optimise est recherche. La contribution des hypoglycemies a l’augmentation de mortalite cardiovasculaire dans l’etudeAction to control cardiovascular risk in diabetes (ACCORD) n’est pas clairement etablie. Le delai entre les hypoglycemies et les evenements cardiovasculaires a ete considere trop long pour attribuer aux hypoglycemies une responsabilite directe. Cependant, plusieurs modifications cardiovasculaires, notamment hemodynamiques et de la repolarisation ventriculaire, impliquant en particulier l’activation sympathique, peuvent etre observees au moment, ou au decours, d’une hypoglycemie. L’insuline elle-meme, surtout s’il existe une insulinoresistance vasculaire associee, comme une neuropathie autonome cardiaque, peut induire des modifications voisines et leurs effets peuvent se cumuler avec ceux de l’hypoglycemie. Chez tout patient diabetique, l’objectif glycemique doit etre defini en considerant la balance entre les risques d’hypoglycemies et ceux lies a leurs consequences, et le benefice de l’equilibre glycemique renforce.
Published: 2011

18. What would be the outcome if the American Diabetes Association recommendations of 2010 had been followed in our pratice in 1998-2006?

Author: Emmanuel Cosson, S. Chiheb, I. Banu, Minh Tuan Nguyen, Paul Valensi, E. Hamo-Tchatchouang, and N. Charnaux
Subjects: medicine.medical_specialty, Diabetes risk, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Overweight, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Abnormal oral glucose tolerance, Internal medicine, Diabetes mellitus, Weight management, Internal Medicine, Medicine, education, education.field_of_study, Framingham Risk Score, business.industry, nutritional and metabolic diseases, medicine.disease, 3. Good health, Metformin, Surgery, medicine.symptom, business, medicine.drug
Abstract: Diabet. Med. 28, 567–574 (2011) Abstract Aims In 2010, the American Diabetes Association has published recommendations on the population to be screened for dysglycaemia; the diagnostic criteria for intermediate hyperglycaemia and diabetes using oral glucose tolerance testing and HbA1c; and the patients eligible for treatment with metformin. We aimed to evaluate the consequences of screening with oral glucose tolerance test or HbA1c in an at-risk population. Methods Among 1177 overweight or obese consecutive adults without known diabetes who were referred to our department for weight management, we selected 1157 individuals (83% female; 80% European) fulfilling the American Diabetes Association 2010 criteria for dysglycaemia screening. Results Mean age was 41.2 ± 13 years, BMI 37.0 ± 7.2 kg/m2, fasting plasma glucose 4.9 ± 0.8 mmol/l and HbA1c (turbidimetric immunoassay) 5.7 ± 0.7% (39 mmol/mol). Based on oral glucose tolerance test and HbA1c, respectively, 76 (6.6%) and 113 (9.8%) patients had diabetes, including 34 sharing both criteria; 307 (26.5%) and 478 (41.3%) had intermediate hyperglycaemia; and 130 (11.2%) and 255 (22.0%) would be treated with metformin. The sensitivity/specificity of HbA1c ≥ 6.5% (48 mmol/mol) for the diagnosis of diabetes according to the oral glucose tolerance test were 44.7/92.7%. Diabetes risk scores and UK Prospective Diabetes Study cardiovascular risk score were the highest in the 130 patients having both an abnormal oral glucose tolerance test and HbA1c ≥ 5.7%. Conclusions In a population at risk for diabetes, the HbA1c strategy could lead to diagnosing more cases of dysglycaemia and to treating more patients with metformin than the oral glucose tolerance test strategy. The consistency of either diagnostic criteria was low. The patients with the highest a priori risk of diabetes and cardiovascular disease were those fulfilling both oral glucose tolerance test and HbA1c criteria.
Published: 2011

19. [Relationship between blood pressure, heart rate and cardiac autonomic dysfunction in non-diabetic obese patients]

Author: I, Banu, M T, Nguyen, E, Hamo-Tchatchouang, E, Cosson, and P, Valensi
Subjects: Adult, Male, Heart Rate, Diabetes Mellitus, Humans, Blood Pressure, Female, Heart, Obesity, Autonomic Nervous System
Abstract: Some studies suggest that a high heart rate (HR) would be predictive of the incidence of an elevated blood pressure (BP). Cardiac autonomic dysfunction (CAD) affects a high proportion of obese patients. CAD could be involved in BP increase. Our aim was to examine the relationship between CAD, HR and BP in obese patients without known diabetes.We included 428 overweight or obese patients. CAD was assessed by analyzing HR variations during three standard tests (Valsalva, deep breathing, lying-to-standing), which are mostly dependent on vagal control. An oral load in glucose was performed and the Matsuda index was calculated.The population was separated in 4 groups according to the grade of CAD (no or only one abnormal test, 2 or 3 abnormal tests) and HR (or ≥ 75 bpm). Age was similar in the four groups. Systolic (P=0.05), diastolic (P0.005) and mean BP (P0.001) differed significantly between the 4 groups, and was the highest in the group of patients who had 2 or 3 abnormal tests and HR ≥ 75 bpm. Matsuda index differed across the groups (P=0.018) and was the lowest in this group.These data indicate that among overweight or obese patients with a defect in cardiac vagal activity BP is elevated only in those with a high heart rate, which is indicative of a more marked insulin resistance and probably an excess in sympathetic activity.
Published: 2015

20. Neuropathie diabétique

Author: P. Valensi, S. Chiheb, and I. Banu
Subjects: business.industry, Medicine, business
Published: 2014

21. Neuropathie périphérique carentielle et encéphalopathie de Gayet-Wernicke après chirurgie bariatrique restrictive

Author: S. Bathaei, I. Banu, S. Chiheb, Paul Valensi, and C. Pillegand
Subjects: Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Internal Medicine
Abstract: Introduction et but de l’etude La carence en vitamine B1 quand elle est symptomatique est une des rares mais redoutees complications postoperatoires des chirurgies bariatriques malabsorptives. Elle peut provoquer des neuropathies peripheriques graves voire une encephalopathie de Gayet-Wernicke pouvant etre irreversibles. Materiel et methodes Nous rapportons six cas de patientes ayant presente une neuropathie peripherique dont un avec encephalopathie, secondaires a une carence en vitamine B1 dans les suites d’une chirurgie restrictive. Resultats et analyse statistique Cinq cas sont survenus apres gastrectomie longitudinale et un apres pose d’un anneau gastrique ajustable. Les patientes etaient âgees entre 20 et 47 ans. Les symptomes sont apparus entre 1 et 8 mois apres la gastrectomie longitudinale et 7 ans apres la pose de l’anneau gastrique. Il n’existait pas de carence vitaminique en particulier en vitamine B1 en preoperatoire. Les patientes n’ont pas recu de supplementation vitaminique systematique ni avant ni apres la chirurgie. Elles avaient avant l’apparition des symptomes carentiels, des vomissements ou un RGO entravant l’alimentation. Toutes etaient atteintes d’une polyneuropathie axonale sensitive et/ou avaient une atteinte motrice avec une encephalopathie de Gayet-Wernicke dans un cas. Les symptomes ont ete ameliores significativement chez la majorite apres perfusion intraveineuse pendant plusieurs jours de fortes doses de vitamine B1 associe aux autres vitamines (B6, PP, polyvitamines, oligoelements). Aucune autre etiologie n’a ete retrouvee (pas de diabete ni d’ethylisme). Conclusion Malgre la realisation d’un bilan preoperatoire exhaustif comportant la recherche de carences vitaminiques notamment en vitamine B1, une neuropathie peripherique carentielle et une encephalopathie de Gayet-Wernicke peuvent survenir apres chirurgie bariatrique restrictive. Dans les cas rapportes, les patientes presentaient toutes des vomissements ou un RGO alterant l’alimentation. Aucun cas n’a ete observe en l’absence de ces symptomes. Les neuropathies peripheriques carentielles et l’encephalopathie de Gayet-Wernicke sont des complications rares mais graves de la chirurgie bariatrique meme restrictive malgre l’absence de carence preoperatoire. Ces complications sont reversibles si elles sont diagnostiquees et traitees precocement par supplementation vitaminique. Cette supplementation devrait etre entreprise le plus rapidement possible chez les patients presentant des vomissements ou un RGO afin d’eviter l’apparition des symptomes carentiels.
Published: 2016

22. What would be the outcome if the American Diabetes Association recommendations of 2010 had been followed in our practice in 1998-2006?

Author: E, Cosson, M T, Nguyen, E, Hamo-Tchatchouang, I, Banu, S, Chiheb, N, Charnaux, and P, Valensi
Subjects: Adult, Blood Glucose, Glycated Hemoglobin, Male, Diabetes Mellitus, Type 2, Outcome Assessment, Health Care, Practice Guidelines as Topic, Humans, Mass Screening, Female, Glucose Tolerance Test, Overweight
Abstract: In 2010, the American Diabetes Association has published recommendations on the population to be screened for dysglycaemia; the diagnostic criteria for intermediate hyperglycaemia and diabetes using oral glucose tolerance testing and HbA(1c); and the patients eligible for treatment with metformin. We aimed to evaluate the consequences of screening with oral glucose tolerance test or HbA(1c) in an at-risk population.Among 1177 overweight or obese consecutive adults without known diabetes who were referred to our department for weight management, we selected 1157 individuals (83% female; 80% European) fulfilling the American Diabetes Association 2010 criteria for dysglycaemia screening.Mean age was 41.2 ± 13 years, BMI 37.0 ± 7.2 kg/m(2), fasting plasma glucose 4.9 ± 0.8 mmol/l and HbA(1c) (turbidimetric immunoassay) 5.7 ± 0.7% (39 mmol/mol). Based on oral glucose tolerance test and HbA(1c), respectively, 76 (6.6%) and 113 (9.8%) patients had diabetes, including 34 sharing both criteria; 307 (26.5%) and 478 (41.3%) had intermediate hyperglycaemia; and 130 (11.2%) and 255 (22.0%) would be treated with metformin. The sensitivity/specificity of HbA(1c) ≥ 6.5% (48 mmol/mol) for the diagnosis of diabetes according to the oral glucose tolerance test were 44.7/92.7%. Diabetes risk scores and UK Prospective Diabetes Study cardiovascular risk score were the highest in the 130 patients having both an abnormal oral glucose tolerance test and HbA(1c) ≥ 5.7%.In a population at risk for diabetes, the HbA(1c) strategy could lead to diagnosing more cases of dysglycaemia and to treating more patients with metformin than the oral glucose tolerance test strategy. The consistency of either diagnostic criteria was low. The patients with the highest a priori risk of diabetes and cardiovascular disease were those fulfilling both oral glucose tolerance test and HbA(1c) criteria.
Published: 2011

23. Bioethanol used in Alkylation of Benzene over Modified ZSM-5 Catalysts with Nd and Pr

Author: AG, Parciulea, primary and I, Banu, additional
Published: 2015
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24. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

Author: S. Artigas, A V Dreval, Mark I. McCarthy, C Watson, Peter H. Bennett, M Quint, Y Ikeda, E Alpert, F Schiele, H Sekihara, Erik Gylfe, P Lowe, J Kuhlmann, Alain Golay, V Longo, Shahidul Alam Khan Akm., L G Mantovani, M Zawodniak-Szalapska, G Winkler, T Harrity, L Virág, U Johne, Kuo S-W., Linda C Tapsell, J Rodriguez, Michel Komajda, K Kankova, Carole A. Cull, M Sporna, E Estilles, U Ribel, M C Spruce, E Buzzigoli, T Prazak, J K McLaughlin, M K Lingohr, M Lim, F Calara, A Siebenhofer, G Meregalli, Roberto Anichini, A D Baron, R Kurashvili, P C Butler, G I Fantus, T. E. De Gooyer, Park Y-M., R. Walther, S Heinrich, Agnieszka Zawiejska, S Mukherjee, Nikolaos Papanas, G Wong, Ian D. Caterson, David M. Maahs, Shuichi Kaneko, Alexandra E. Butler, Francisco Javier Ampudia-Blasco, O N Kong, Attali J-R., C A Hedman, K Oshinyemi, Nicolle Müller, I C Cranston, N Okumus, M V Vlaiculescu, Balasubramanian Ravikumar, W W Cheatham, K Mukasa, K B Biswas, Annunziata Lapolla, Phil McEwan, G Mader, Gilles Chassot, Dragi Anevski, Werner A. Scherbaum, M Donath, C Hesselmann, R A Gandhi, David E. Moller, Ezio Bonifacio, C Garcia, V Ifandi, P Hornnes, Nieuwenhoven Fav., C Puech, S Pérez-Del-Pulgar, Kim S-R., G Hines, C Rubio Terrés, Michael Gaster, N. Hosszufalusi, A Scholze, Andrew A. Young, Stavros Liatis, F Hariri, S Tan, Paul Valensi, Allan E. Karlsen, J Kim, E. Moberg, J Kaiser, L Berman, G Nelson, A Altkrüger, P Kothare, D B Cook, S Doran, G. van Dijk, Shahnaz Shahinfar, Kim C-S., P Stahl, M Manousaki, S Sigrist, S K Lim, M. P. Stern, A Guberti, C Rezzani, J McKenney, Karl Thomaseth, Sofia Carlsson, M Julia, R Brillante, I Rubesova, T Darkow, E Matsumoto, Wendy M. Macfarlane, M Di Martino, G Bardini, Rossella Menghini, D Duhot, E Farcasiu, Annalisa Natalicchio, I Lindner, J Buvat, Christian L. Brand, Harry Dorchy, Iwona Pietrzak, Z T Luo, P Home, M Ekelund, Jesper Gromada, Kristine Færch, F Piarulli, H Kim, R Mentel, Zsuzsanna K. Zsengellér, Dullaart Rpf., Anton Luger, Thomas A. Pearson, V Manicardi, P Rösen, Feng Y-M., R Morganti, Lars Hansen, Demuth H-U., Haruo Kasai, A Shostak, Rudi Steffensen, G Taylor, Markolf Hanefeld, C Santini, E Hamaguchi, Roberto Miccoli, F Storms, M Cooper, Y Lee, Allison E. Aiello, P Smith, T Suehiro, K Treece, M Waluś, Timothy A Welborn, Simone Baltrusch, E Kontela, S Chai, J Crean, H Yokoyama, Johan G. Eriksson, Rafael Hernández Hernández, J Rodríguez-Saldaña, M P Tornero, G Formoso, D. Lovell, E Bingham, A Mylonakis, M Manteghetti, D Fedele, Antonio Martín-Duce, Ralph A. DeFronzo, D Salcedo, Kurt Højlund, Antonio Petrone, Sheu Whh., C Gutierrez, Flavia Pricci, S Kurita, Z G Abbas, M M Benedetti, Philippe A. Halban, Daniel J. Cox, O Ljungkvist, Justine Davies, J Palsgaard, Lars Sjöström, E Bosi, L Janin-Manificat, W. F. Kelly, M. Fernandez, E Colak, O V Mulyarchik, B Kronshage, F Lang, M Erfurth, Takashi Kadowaki, N Jendrike, U Walter, J Wishart, Y. Neye, D Kim, N Furuhashi, M Barsotti, D Florow, L Ke, L Borgquist, N C Jackson, Ffolliott M. Fisher, V Baskar, K Yoshioka, Bryan A. Wolf, G Chabrier, R Skoumal, Livio Luzi, H Kose, I Pharisien, B. Klein, H Winiarska, M C Johnson, L Griffiths, Nonna Kravchun, C Combe, Baptist Gallwitz, J Zdychova, L Skorda, Jorma Ilonen, W Gao, I N Steen, A Terrinoni, P D Ambery, W Kern, C M Kusminski, Cho M-H., Paolo Pozzilli, Louise G. Grunnet, E Schönle, David R Matthews, Robert W. Taylor, Y Cohen, Kim H-S., M P Eccles, N B Tutuncu, D McDowell, Richard M. Bergenstal, K Takamatsu, T Steiner, Jaan Palgi, Valdemar Grill, N Niculescu, G Federici, S Lehto, P. M. McKeigue, M Barone, Michael E. Trautmann, S Smirnov, J Mannion, M Eto, C Rousseau, M Conti, C S Ernest, Antonio Ceriello, D H Schweitzer, Jung E-D., Andreas Festa, Avijit Lahiri, A Shepelkevich, A Murro, A Kollmann, Jonathan R.S. Arch, R Landgraf, Son H-Y., I Engelsberger, E Agardh, S Rodríguez-Mulero, P J Kraml, K Lee, D. F. Du Toit, E Kim, G Fadini, Williams Ajk., Philip Home, M B Antcieferov, C Perlemoine, D Perrea, Song X-L., D Ruggieri, Krister Bokvist, Heidi Sørensen, Bilbao, G Yoshino, J P Taylor, Shen H-M., S M Furier, R Urquhart, J Wohlgelernter, Jianping Weng, T. Baba, Q Hong, C Silva, Castaigne J-P., M Felaco, X X Zhang, M Jaroň, Milla Rosengård-Bärlund, J G Papp, Toshio Miyata, Lervang H-H., Park M-K., I Kinalska, A Long, Oomen Phn., N Kogawa, Ippolita Patrizia Patera, S. Karadeniz, Dinesh Selvarajah, D S Chung, A Wensaas, Richard Imrich, M Recasens, J Ruxer, O Buchea, E Wilpart, S P Stepanenko, Le Ttd., H Ohgawara, Mariaconsuelo Valentini, A Mondok, M Peltonen, Marianne O. Larsen, K Chatzianagnostou, Agneta Ståhle, A L Ferrari, L Bordier, F Maingrette, A Matsuda, G Vukomanovic, Jakob D. Wikstrom, T Yamakita, E Gorostiaga, J Jin, B Gopalan, Heinz Drexel, S Hewitt, Rury R. Holman, C Dieterle, T L Ruchti, N Asatiani, M Sidira, A Iezzi, A J Sommerfield, D Châtenet, M L Olsen, R Bergemann, C Koehler, T L Kuraeva, B Balas, Christian Berne, E Santos-Mazo, G Smith, A Siejka, R Kožnarová, A Mattina, S Sheikh, A Adomeit, M Rasmussen, J. Fagerudd, N Busciantella Ricci, Nuria Vilarrasa, E Hammar, T L Thoms, L Aydın, Ron G. Rosenfeld, A Nikolajuk, R Gos, C L Morgan, H L Yu, D Dheelchand, S Ramrath, N Boudriga, Jerome I. Rotter, C Jahannault, W M Weston, Folke Lindgärde, M Hertlova, D Knight, A Monroy-Mayorga, E Pardini, A Chamson-Reig, B Franke, Janie McCluskey, Joseph Bryan, C Nikolopoulou, Christie M. Ballantyne, Fausto Santeusanio, L Pegoraro, M Lee, A Klimenko, S Jaiveer, K. Pettersson-Fernholm, Michael A. Nauck, A Ekbom-Schnell, G Deferrari, Riccardo Schiaffini, S. Pampanelli, Khan Aka., David Hopkins, Maija Wessman, M Kamarinos, Noh J-H., O Ebisui, K McCarroll, Jeppe Sturis, Peter Nowotny, N Gorbenko, Åke Sjöholm, David G. Maggs, A E Halseth, B Cresci, A A Ortiz-Gress, A Korakovouni, O Matejkova, C E Mogensen, C J Lin, Ramon Gomis, H Seaman, C Granier, Yang C-H., F Assah, O Sanchez, Fausto Machicao, Peter G. Morris, Alberto Ortiz, A Giardinelli, D Bracaglia, A Gonzalo, S Pavlatos, Andreas Lechner, F Canovic, L Sjolind, Allan Vaag, Birgitte Bruun Nielsen, David A. Ziegler, Vito Lampasona, R Gershoni-Baruch, A. Dei Cas, H Renz, E Mena, Matthew Waltham, Kim D-M., H Levanen, D D Mick, Valentina Alexandrovna Peterkova, E Meskhishvili, Sarah Nutland, R Bustani, John R. Lindsay, M Christoforidou, A Abicht, E Harno, K Cyganek, A Fitchet, S Neelotpol, P Nikishin, P Serradas, J Hinrichsen, M Halvorson, M Chovatia, B Voet, Jinny Willis, E Parretti, M Haslbeck, M Wellard, L Teng, Julio Wainstein, J S Fischer, K. Lalic, D Roggenland, I Gich, R Anwar, Maurizio Cassader, D Serota, X J Li, R J Schotzinger, Vilmundur Gudnason, Björn Zethelius, S A Wootton, W Andrzejewski, R Rezsohazy, R Gao, T Klimentova, T Mazurek, I Bruckner, C Dohrmann, R E James, G daSilva Xavier, Kim S-Y., A Dorca, Stuart J. Pocock, Terri J. Allen, I Giovos, P B Parab, N H Andersen, P Fotinakis, Miriam Cnop, H Lee, Norbert Tennagels, Omorodola I. Abatan, F Ailett, I. Lager, D Manzella, H Hut, Larry A. Distiller, G Lip, Lim S-K., Rong Zhang, T Tsuno, Steen Knudsen, M. Bajardi, Manuel Benito, Dai Sugimoto, Melvin J. Prince, D W Dunstan, D Rankins, K A Majali, G Ozansoy, Isabella Russo, S Uçak, G Annuzzi, R Talar-Wojnarowska, K Lange, S Neugebauer-Baba, Campbell H. Thompson, Eric Renard, P. D. Mountjoy, Z Morrison, Elizabeth A. Davis, Franco Cavallo, C Corvaja, R Antuña, Craig John Currie, H Linnebjerg, He Y-L., A J Palmer, Mariola R. Chacón, H Malinska, M. Jones, R Lichnovská, K Mandes, Paolo Tessari, T Mokhort, A Laina, H. L. Y. Chan, I Schmidt, R Banks, Richard G. IJzerman, L Ksinantova, G Setti, H Vaudry, A Gallo, V Spallone, Chen J-W., Thomas Danne, A Chong, M Hallschmid, S Aczel, S Hulme, N Islam, M Hosoi, P M Ternan, P Di Bartolo, N Bishara, T Shibasaki, Martin A. Osterhoff, Im S-S., M Jecht, T Hamaguchi, S Mattera, K Ways, Elizabeth Northam, U Rajala, Reinhard W. Holl, L Yang, S Panaiotopoulos, K Horvath, R Kluge, Thora B. Bodvarsdottir, Y Dong, Irene Alemanno, C McDougall, Reimar W. Thomsen, M Campbell, W Rabl, John Öhrvik, Yuichiro Yamada, Paola Ungaro, W Benzer, Mike Sampson, Roberto Trevisan, R G Radu, Aas A-M., P E Lobo, Ricardo Scott, S M Son, Josephine M. Forbes, T A Hillier, K L Wyne, Louis L. Nguyen, J Farmer, M H Tan, Kwon H-S., J Yang, L Sandvik, Franco Folli, A K Jenum, M Nguyen, W Pratipanawatr, A L Frederiksen, Rebecca Smith, Lee H-J., A Schäfer, C Manuelli, G S Denver, T Vukovich, B Maceira, K Matsumoto, K. Chokkalingam, Nurcan Üçeyler, P Modi, Timothy M. Morgan, S Mertens, B M Singh, Michaela Riedl, K Iso, C Cucurullo, G. F. Bottazzo, M Calvani, K Hur, J Wetzels, Kazuhiro Takahashi, Y Aso, H Stammer, M G Masding, Fitsum Guebre-Egziabher, J L González-Sánchez, L Armstrong, Alberto Maran, Peter G.F. Swift, S S Popovic, J Starczynski, E Vitacolonna, Luigi Laviola, R W Gelling, Marina Cardellini, D Barilla, Rosa de Diego Martínez, W H Landschulz, Anne Mette Rosenfalck, R K Wong, Kevin E. Schneider, K Peros, Giuseppe Nanni, F Zhang, I Rákóczi, T Iburi, M Nakhjavani, X Q Zhang, S Tournis, Per Lav Madsen, Graham A. Hitman, A. Tura, K Laubner, N D Kostic, Lawrence M. Dolan, R. Sinha Roy, J A Wagner, J. Tuomilehto, J Hauptman, M Abdel-Ghany, D Lacombe, Toralph Ruge, Johannes A Maassen, Triantafyllos Didangelos, K Sasaki, I Argüelles, Klaus Levin, C Popow, Emanuel Christ, R Chetty, L Baillet-Blanco, Jo-Ann Salmon, T Mine, James L. Trevaskis, I Franke, J Gorski, E A Andrianova, A Dayan, A Caballero, Aleksandra Gilis-Januszewska, M Yasujima, Z Kasalová, C.D.A. Stehouwer, F. K. Gorus, G A Nichols, A Glowania, David P. Strachan, P Fredlund, N. F. da Silva, P Reboldi, M Sausbier, K H Groenier, G Stuccio, N Guttman, K R Ahmed, A D Ristic, T Kapellen, J Coutcher, Aldo V. Greco, Oswald Wagner, A Zagayko, Maria Alevizaki, B B Zhang, W F Ferris, Jenny Fredriksson, Lois Jovanovic, J Hänninen, R De Giglio, Kazuo Yagui, O Potterat, P Hamliton, R E Scranton, B Mankovsky, A Stylianou, B Fellström, Abdel-Wahab Yha., M Kitagawa, Katherine L. Baldock, F R Johnson, F Baigts, S D'Addato, F J Sanz, A Mistry, S D Wise, T Pratipanawatr, U R Fölsch, James R.C. Parkinson, Claudia Sommer, C Park, F E Griffiths, M L Martí, R Demirtunc, S Taniguchi, J Lundkvist, T Siegmund, Juan Sztajzel, C Dienesch, F Baumgartner, L Scalone, T M Mckolanis, K Otake, Ullrik Pedersen-Bjergaard, T M Vriesendorp, Michael B. Wheeler, Henry Schmitt, Peter Hovind, S Lange, Stephane Roze, L. Van Gaal, B Klaproth, Anthony E. Civitarese, D Eckland, A Dagar, D F Hopkins, Kari Stefansson, C Gonzalez-Yanes, B Meyboom-de Jong, D. J. Betteridge, K Buhling, M Crepaldi, Ana M. Wägner, L Renna, L Volpe, R McBride, V Corbo, E O Brennesvik, R P Hayes, R Abdollahnia, G Viviani, C F Liew, Francisco Pérez-Bravo, Jeffrey Baron, Brian M. Frier, H H Samira, D Szentendrei, K. J. Schjoedt, W K Waldhäusl, D Gniuli, D Zou, G Tschank, V Urbančič, A L Nolan, Albertini J-P., J Malcomson, M Larbig, C Cheyssac, K Aurich, C M Kesson, S Heller, Maija E. Miettinen, R F Luco, Adrian J. Cameron, Luigi Mattiello, Z. Metelko, X E Zhang, M Parramón, I. G. 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Liu, H, Jeong, I, Chae, M, Choi, M, Yoo, H, Kim, C, Yun, M, Na, M, Kang, Y, Kong, O, Son, S, Kim, I, Tanaka, N, Hosoi, M, Matsuyama, Y, Fukumoto, M, Yamakita, T, Yoshioka, K, Ishii, T, Sato, T, Fujii, S, Aoki, T, Shibata, T, Mizutani, N, Suzuki, J, Fowelin, J, Samuelsson, P, Brandrup wogsen, G, Okumura, K, Tokmakova, A, Staroverova, D, Antcieferov, M, Shutichina, I, Kuntchevich, G, Vriesendorp, T, Morélis, Q, Legemate, D, Schaper, F, Mainas, E, Gkioulmpasanis, I, Panagiotou, I, Vassilikos, G, Skorda, L, Sidira, M, Christoforidou, M, Alaveras, A, Artikis, V, Evdemon, E, Lechleitner, M, Koch, T, Ebenbichler, C, Sturm, W, Moretti, L, Moruzzo, D, Boldrini, E, Pandolfo, C, Kameyama, M, Iwasa, R, Cho, M, Nam, J, Huh, K, Kaplar, M, Paragh, G, Erdei, A, Csongradi, E, Garai, I, Varga, J, Galuska, L, Udvardy, M, Higa, M, Kaneko, Y, Hiroi, N, Koziarska, D, Nowacki, P, Majkowska, L, Luzniak, P, Wojciechowska luźniak, A, Tushuizen, M, Nieuwland, R, Snoeck, D, Sturk, A, Diamant, M, Aguiar, L, Bahia, L, Villela, N, Laflor, C, Conde, C, Bottino, D, Dorigo, D, Bouskela, E, Pu, S, Luo, Z, Lam, K, Dan, Q, Xu, A, Shen, J, Cheng, K, Xu, J, Thamer, C, Stefan, N, Haap, M, Heller, E, Tschritter, O, De Prado, A, Ortiz, A, Ybarra, J, Gich, I, Pou, J, Ehren, M, Roggenland, D, Reinsen, B, Klein, H, Rittig, K, Stock, J, Kocher, B, Balletshofer, B, Shon, H, Chung, D, Nakatani, Y, Matsuhisa, M, Kaneto, H, Hatazaki, M, Yoshiuchi, K, Katakami, N, Kawamori, D, Ohtoshi, K, Sakamoto, K, Matsuoka, T, Ozawa, K, Ogawa, S, Hori, M, Yamasaki, Y, Zitouni, K, Harry, D, Nourooz zadeh, J, Earle, K, Olesen, P, Franco, L, Corvaja, C, Semplicini, A, Ceylan işık, A, Arı, N, Rösen, P, Lee, I, Park, K, Jung, E, Shin, D, Jo, S, Obuobie, K, Prakash, P, Hanna, F, Lazarus, J, Varadhan, L, Gurushankar, J, James, D, Sheikh, S, Gaede, P, Zou, D, Vilarrasa, N, Perez maraver, M, Mena, E, Perez, D, Setti, G, Buckingham, R, Urbančič, V, Stefanovska, A, Bernjak, A, Ažman juvan, K, Kocijančič, A, Glowania, A, Filters, T, Fosmark, D, Torjesen, P, Kilhovd, B, Berg, T, Sandvik, L, Hanssen, K, Mentink, C, Donchenko, G, Stepanenko, S, Maingrette, F, Deng, H, Lindenmair, A, Freudenthaler, A, Baumgartner parzer, S, Nizheradze, K, Khoruzhenko, A, Tronko, N, Sheu, W, Ou, H, Shen, H, Lin, T, Wu, H, Yang, C, Mogylnytska, L, Schmoelzer, I, Davies, J, Band, M, Struthers, A, Prázný, M, Škrha, J, Kasalová, Z, Neelotpol, S, Jahan, P, Kauschke, S, Harrop, C, Schäfer, A, Widder, J, Eigenthaler, M, Walter, U, Uchimura, I, Ikebukuro, M, Kaibara, M, Hirata, M, Helal, R, Pervin, F, Yang, X, Jansson, P, Nagaev, I, Jack, M, Carvalho, E, Sunnerhagen, K, Cam, M, Cushman, S, Smith, U, Creely, S, Farmer, J, Gustafson, B, Kusminski, C, Krusinova, E, Wohl, P, Klementova, M, Lanska, V, Mcdougall, C, Kelly, I, Abbas, Z, Lutale, J, Archibald, L, Karunajeewa, H, Stingemore, N, Stuccio, G, Mcgechie, D, Muller, L, Hak, E, Goudzwaard, W, Montorsi, F, Homering, M, Sprenger, K, Goldstein, I, Asnaghi, V, Ferrari, G, Rastaldi, M, Gabellini, D, Dell'Antonio, G, Maestroni, A, Ruggieri, D, Luzi, L, Piemonti, L, Zerbini, G, Anafaroglu, I, Tutuncu, N, Sultana, M, Siddiqua, N, Iwasaki, T, Nakajima, A, Yoneda, M, Mukasa, K, Tanaka, S, and Sekihara, H
Subjects: 0303 health sciences, medicine.medical_specialty, business.industry, EASD, Endocrinology, Diabetes and Metabolism, Human physiology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Family medicine, Internal Medicine, Medicine, business, 030217 neurology & neurosurgery, 030304 developmental biology
Published: 2004

25. P29 La cardiomyopathie diabétique existe-t-elle ? Données à partir d’une série de 656 patients asymptomatiques

Author: M.T. Nguyen, I. Pham, I. Banu, S. Chiheb, C. Pillegand, N. Assad, and P. Valensi
Subjects: Endocrinology, Endocrinology, Diabetes and Metabolism, Internal Medicine, General Medicine
Abstract: Introduction La cardiomyopathie diabetique est definie comme une alteration myocardique structurelle et/ou fonctionnelle due au diabete en l’absence de facteur de confusion : hypertension arterielle (HTA) ou coronaropathie. Ce dernier critere est habituellement non rapporte dans les etudes. Patients et methodes 656 diabetiques de type 2 depuis 14 ± 8 ans (359 hommes, 59,7 ± 8,7 ans, HbA1c 8,7 ± 2,1 %), asymptomatiques sur le plan cardiaque avec au moins 1 facteur de risque (HTA 74 %; dyslipidemie 70 %; tabagisme 22 %; arteriopathie peripherique 10 %, nephropathie 39 %) ont eu une echographie cardiaque de repos contributive; une scintigraphie a la recherche d’ischemie myocardique silencieuse (IMS, n = 206), avec coronarographie en cas de positivite (stenoses coronaires, SC : n = 71). Resultats Chez les DT2 sans HTA ni SC (n = 157), l’hypertrophie ventriculaire gauche (HVG : 24,1 %) etait l’anomalie la plus frequente, suivie par dilatation du VG (8,6 %), hypokinesie (5,3 %), trouble de relaxation de type 1 (TbRelax 4,8 %) et dysfonction systolique (3,8 %). Aucune variable n’etait associee a HVG ni dilatation du VG ni TbRelax. En analyse multivariee, les determinants de l’hypokinesie etait l’IMS (Odds ratio 14,7 [2,7–81,7], p Conclusion Chez les DT2 asymptomatiques, la cardiomyopathie diabetique constitue une entite tres frequente et caracterisee essentiellement par une HVG. L’IMS, l’obesite et le desequilibre glycemique participent a la dysfonction systolique et/ou l’hypokinesie. L’HTA est associee a plus d’HVG, les SC a plus d’hypokinesie.
Published: 2012

26. Insuffisance hypophysaire révélatrice d’une toxoplasmose cérébrale inaugurale d’une infection VIH

Author: P. Valensi, L. Iordache, I. Banu, and O. Steriade
Subjects: Endocrinology, Endocrinology, Diabetes and Metabolism, General Medicine
Abstract: Introduction La toxoplasmose cerebrale est la manifestation inaugurale du SIDA dans environ 15 a 20 % des cas. Elle se manifeste habituellement par des signes neurologiques (convulsions febriles, meningo-encephalite, signes de localisation). Nous presentons le cas d’une patiente ayant developpe une insuffisance hypophysaire et un diabete insipide lors d’une toxoplasmose cerebrale inaugurale d’une infection VIH. Observation Il s’agit d’une patiente âgee de 53 ans, adressee pour un syndrome polyuropolydipsique et une alteration de l’etat general avec amaigrissement de4 kg. Il existait une hypernatremie a 155 mmol/l. La TSH etait basse a 0,21 mU/l avec T4l et T3l normales. Le taux du cortisol plasmatique a 8 h etait bas (46 nmol/l) et non reactif au Synacthene®, avec une ACTH indosable. Devant ce tableau, un bilan hypophysaire complet a ete realise, retrouvant une insuffisance gonadotrope et thyreotrope et une hyperprolactinemie a 104 μg/l. Le bilan decouvre egalement une pancytopenie accompagnee d’une hypergammaglobulinemie polyclonale. Rapidement la patiente a presente un etat febrile et une dyspnee aigue. La serologie VIH est revenue positive et l’IRM cerebrale a visualise des lesions multiples evoquant une toxoplasmose cerebrale. Sous traitement anti-toxoplasmose, hydrocortisone, levothyroxine et desmopressine, l’etat de la patiente s’est ameliore. A 6 mois de traitement, l’insuffisance corticotrope s’est amendee, tandis que persistent le diabete insipide et l’insuffisance thyreotrope. Discussion La toxoplasmose cerebrale est une infection due a un parasite ubiquitaire, Toxoplasma gondii, touchant les sujets immunodeprimes par reactivation. L’insuffisance hypophysaire est rare, mais peut persister durablement, malgre le traitement etiologique, comme chez notre patiente.
Published: 2014

27. O11 Valeur pronostique du taux plasmatique de N-terminal pro-B-type natriuretic peptide (NT-proBNP) chez les diabétiques asymptomatiques

Author: P. Valensi, M. Nguyen, I. Pham, I. Banu, B. Chanu, and E. Cosson
Subjects: Endocrinology, Endocrinology, Diabetes and Metabolism, Internal Medicine, General Medicine
Abstract: Introduction Nous avons precedemment montre que le NT-proBNP est un marqueur de stenoses coronaires (SC) chez les diabetiques asymptomatiques au plan cardiaque. Ce marqueur est reconnu comme predicteur d’evenements cardiaques. Le but etait ici de determiner sa valeur pronostique independante de la maladie coronaire silencieuse et d’une hypertrophie ventriculaire gauche (HVG). Patients et methodes Nous avons inclus 323 patients diabetiques (17 type 1, 306 type 2) sans antecedent ni symptome cardiaque mais ayant ≥ 1 facteur de risque associe. L’ischemie myocardique silencieuse (IMS) a ete recherchee par scintigraphie myocardique de stress et les SC par une coronarographie pratiquee en cas de positivite. La masse ventriculaire gauche a pu etre evaluee de facon fiable par echocardiographie (convention ASE) chez 282 d’entre eux, l’HVG etant definie par une masse VG ≥ 106 (femmes) ou 110 g/m2 (hommes). Le NT-proBNP a ete dose. Resultats Une HVG etait presente chez 92 patients, l’IMS chez 108 patients dont 39 avaient des SC. Les tertiles superieurs de NT-proBNP s’associaient a une plus forte prevalence d’HVG (19,4, 35,1 et 43,2 % ; p 34 pg/ml) predisait les evenements independamment de l’IMS (OR 2,9 [1,4–6,0], p Conclusion Cette etude suggere que le taux plasmatique de NT-proBNP constitue, chez les diabetiques asymptomatiques, un marqueur de risque d’evenements cardio-vasculaires independant du statut coronarien et de l’HVG.
Published: 2014

28. P238 - Rôle d’une dysfonction autonome cardiaque dans l’hypertension artérielle et l’augmentation du risque coronarien chez les obèses

Author: E. Cosson, M. Vivier, Minh Tuan Nguyen, P. Weinmann, and I. Banu
Subjects: Endocrinology, Endocrinology, Diabetes and Metabolism, Internal Medicine, General Medicine
Abstract: Introduction La dysfonction autonome cardiaque (DAC) contribue a l’elevation de la pression arterielle et du risque cardiovasculaire chez les diabetiques. L’obesite est souvent associee a une DAC. Le but etait, chez les obeses sans diabete connu, d’evaluer le role de la DAC dans l’hypertension arterielle (HTA) et le role respectif de la DAC et de l’HTA dans l’augmentation du risque coronarien. Patients et methodes Nous avons inclus 377 patients obeses ou en surpoids (IMC 39 ± 7 kg/m 2 ), âges de 38,3 ± 14,6 ans. Une charge en glucose a ete effectuee. Une DAC a ete definie par au moins un test anormal parmi 3 tests (respiration profonde, orthostatisme, Valsalva), sous dependance vagale predominante, evaluant la variabilite de la frequence cardiaque. La DAC etait consideree severe si 2 ou 3 tests etaient anormaux. Le score UKPDS de risque d’evenements coronariens a 10 ans a ete calcule. Resultats Une DAC etait presente chez 158 patients (44 %) et l’HTA chez 131 patients (35 %). La prevalence de l’HTA etait significativement plus elevee chez les patients avec DAC severe (50 %) que chez ceux sans (30 %) ou un seul test (38 %) de DAC anormal (p = 0,01). Le score UKPDS etait significativement different entre les 4 groupes (p Conclusion Chez les obeses sans diabete connu, la presence d’une DAC pourrait, du fait d’une predominance sympathique, contribuer a l’elevation tensionnelle et a aggraver le risque coronarien chez les hypertendus.
Published: 2011

29. <![CDATA[A pulmonary ventricle system producing pulsatile pressure in single ventricle: experimental model]]>

Author: Emrecan, Bilgein, primary, Kestelli, Mert, additional, Yilik, Levent, additional, Laf�i, Banu, additional, �zs�yler, Ibrahim, additional, G�rb�z, Ali, additional, and �zbek, Cengiz, additional
Published: 2006
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30. An alternative parameter for monitoring the therapeutic benefits of allopurinol simultaneously in renal ischaemia-reperfusion injury: MDA/ATP Ratio

Author: Bor, Mustafa Vakur, primary, Durmus, Osman, additional, Cay�i, Banu, additional, and T�rk�zkan, Nurten, additional
Published: 2000
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31. [Science-philosophy rapport in Epidemics I, II and associated writings of C. H]

Author: I, Banu
Subjects: Science, Greece, Ancient, Humans, Manuscripts, Medical as Topic, Philosophy, Medical, History, Ancient
Published: 1989

32. Akut lityum karbonat uygulamasının farelerin beyin lipid peroksit düzeylerine etkisi

Author: Ayça, İ. Banu, Uysal, Meral Keyer, and Farmakoloji Anabilim Dalı
Subjects: TIP
Published: 1988

33. Abdominal lymphography with radiogold 198Au-colloid in malignant lymphoma and metastases of various neoplasms

Author: I, Pană, I, Banu, and S, Nicolaescu
Subjects: Gold Colloid, Radioactive, Abdomen, Humans, Lymph Nodes, Neoplasm Metastasis, Radionuclide Imaging, Hodgkin Disease
Published: 1975

34. [Study on the incorporation of radioactive phosphorus (P32) by blood elements under the influence of x-rays. I. Incorporation of P32 by the leukocytes of irradiated dogs]

Author: I, BANU, L, VLAD, V, DRAGON, and S, CASAT
Subjects: Dogs, X-Rays, Leukocytes, Animals, Phosphorus, Radiation Injuries
Published: 1961

35. [CONTRIBUTIONS TO THE STUDY OF THE CYTOMORPHOLOGICAL CHANGES IN EHRLICH'S ASCITES CARCINOMA UNDER THE INFLUENCE OF RIBONUCLEASE AND DESOXYRIBONUCLEASE]

Author: A G, CIPLEA, E, SORU, and I, BANU
Subjects: Pharmacology, Mice, Deoxyribonucleases, Ribonucleases, Research, Carcinoma, Animals, Ascites, DNA, Carcinoma, Ehrlich Tumor
Published: 1964

36. [The metabolism of glutamic acid and of glutamine in neoplasms and non-neoplastic tissues. 1. Study of reactions of transamination]

Author: I, BANU and I, POPP
Subjects: Glutamates, Biochemical Phenomena, Glutamine, Neoplasms, Glutamic Acid, Amination
Published: 1960

37. [Prevention of the importing of cholera]

Author: E I, Banu
Subjects: Europe, Asia, Cholera, Romania, Africa, Vaccination, Humans
Published: 1973

38. [Study of the renewal of various fractions of blood proteins in experimental liver cirrhosis in rabbits; use of S35 labelled methionine and C14OOH]

Author: I, BANU
Subjects: Methionine, Animals, Blood Proteins, Lagomorpha, Rabbits, Liver Cirrhosis, Experimental
Published: 1957

39. [Action of ribonuclease and desoxyribonuclease on the incorporation of L-glutamic acid U-C-14 and methionine S-35 in tumor cells of Ehrlich's ascites carcinoma]

Author: E, Soru, I, Banu, M, Lăzărescu, and V, Licurici
Subjects: Methionine, Glutamates, Animals, RNA, DNA, In Vitro Techniques, Carcinoma, Ehrlich Tumor, Rats
Published: 1965

40. [Serum transaminase activity in myocardial infarct]

Author: C C, ILIESCU, L, ROMAN, I, BANU, I, SOIMU, and G, ORGHIDAN
Subjects: Myocardial Infarction, Transaminases
Published: 1958

41. [Study on the incorporation of radioactive phosphorus (P32) by blood elements under the influence of x-rays. II. Incorporation of P32 by the erythrocytes of irradiated dogs]

Author: I, BANU, L, VLAD, V, DRAGON, and S, CASAT
Subjects: Dogs, Erythrocytes, X-Rays, Animals, Phosphorus, Radiation Injuries
Published: 1961

42. [The regime of the school child in school, at home and in day boarding schools]

Author: I, Banu, J, Heilpern, and A, Maiersohn
Subjects: Nursing, Child Care, School Health Services
Published: 1965

43. Kronik bel ağrısı olan erkeklerde 8 haftalık aerobik ve merkezi stabilizasyon egzersizlerinin ağrı ve bazı biyokimyasal parametreler üzerine etkisi

Author: Ahmadkhani, Sima, Ayça, İnci Banu, Beden Eğitimi ve Spor Anabilim Dalı, and Ayça, İ Banu
Subjects: Spor, Öğrenim ve öğretim, Study and teaching, Sports
Abstract: Bu çalışmanın amacı, 8 haftalık aerobik ve merkezi stabilizasyon egzersizlerinin kronik bel ağrısı olan, yaşları 30-50 yaş arası ve 20 erkek denek üzerine bel ağrısı, (Ağırlık (kg), BMI (kg /m2), Boy (cm)), CRP ve ESR, D vitamini, Formül Lökosit , Kalsiyum değişimileri ölçülmüştür.Bu çalışma kapsamında 10 kişi egzersiz yapan grup haftada 3 gün merkezi stabilite çalışması ve 3 günü aerobik dayanıklılık eğitimi almışlar ve 10 kişi kontrol grubu, normal hayatlarına devam etmişler. Hem kontrol grup hem egzersiz yapan grup araştırmaya başlamadan önce ve 8 .haftanın sonunda fizyolojik endeksler ( Ağırlık (kg), BMI (kg/m2), Boy (cm)) CRP ve ESR, D vitamini , Formül Lökosit , Kalsiyum değişimileri ölçülmüştür. Verilerin Değerlendirilmesi için Çalışmada elde edilen bulgular tanımlayıcı Excel 20l0 ve SPSS En son sürüm 25,0.0,0 Paket programı kullanılarak istatistiksel metotlardan (ortalama ve standart sapma) kullanıldı. Yapılan ölçümlerde anlamlılığın belirlenebilmesi için pearson korelasyon test kullanıldı. Aynca verilerin doğal dağılımını belirlemek için kolmogorov ve smirnov testi kullanıldı. Biyokimyasal parametrelerin ölçümü için D vitamini Elisa yöntemi, CRP için türbidimetrik ve Kalsiyıım için colormetrik ,ESR için manual olarak ve Formül lökositi için perifitik yayma giemsa boyama yöntemiyle ve lökosit sayısı Hemogram cihazı yle ölçüldü.sonuç olarak Lenfosit , Eozinofil, Kalsiyum, Formul lokosit, CRP, ESR 1. ve 2. saatten sonra son test ortalamaları grup değişkenine göre anlamlı farklılık göstermemektedir. Kontrol grubunun Mc Gill , D vit ve Monosit son test puanları ,egzersiz yapanların Mc Gill ve D Vit son test puanlarından yüksek bulunmuştur. Egzersiz Yapanların son test Nötrofil puanları kontrol grubunun Nötrofil son test puanlarından yüksek bulunmuştur. Ağrı Son test ile grup arasında anlamlı ilişki bulunmamıştır.--------------------The aim of this study was to investigate the effects of central and aerobic stabilization exercises on low back pain on 20 male subjects aged between 30-50 with chronic low back pain during 8 weeks of Central and aerobic stabilization exercises measuring (weight (kg), BMI (kg/m2), height (cm)) CRP and erythrocyte sedimentation rate, vitamin D, formula Leukocyte and calcium changes. Within the scope of this study, 10 people in the exercise group received 3 days of Central stability study and 3 days of aerobic endurance training and 10 people in the control group continued their normal lives. The physiological indices (weight (kg), BMI (kg/m 2), height (cm)) CRP and erythrocyte sedimentation rate, D vitamin, formula Leukocyte, calcium changes were measured before the study and at the end of the 8th week for both control and exercise groups. Statistical methods (mean and standard deviation) were used using descriptive Excel 20l0 and SPSS latest version 25,0.0,0 package program to evaluate the data. Pearson correlation test was used to determine the significance of the measurements. Kolmogorov and Smirnov test were also used to determine the natural distribution of the data. Vitamin D Elisa method was used for measurement of biochemical parameters.Türbidimetric for CRP and colormetric for calcium manual for ESR and formula for leukocytes with Perifitic spread Giemsa staining method and leukocyte count Hemogram device. As a result, Lymphocyte, Eosinophil, Calcium, Formula leukocyte, CRP, ESR After 1st and 2nd Hours Post-test averages do not show significant differences according to the group variable. The control group's Mc Gill, D Vit and monocyte final test scores were higher than those of the exercise group's MC Gill and D Vit final test scores. The final test scores of the exercise participants were higher than the final test scores of the control group. Pain No significant relationship was found between the last test and the group.
Published: 2019

44. Crossfit antrenmanlarının kadın ve erkek sedanter bireylerde biyokimyasal parametrelere etkisi

Author: Kaygu, Mervan, Ayça, İnci Banu, Beden Eğitimi ve Spor Anabilim Dalı, Ayça, İ Banu, and Beden Eğitimi ve Spor Spor Sağlık Anabilim Dalı
Subjects: Spor, Sedentary, Sportsmen, Öğrenim ve öğretim, Physical education, Study and teaching, Women, Men, Biochemical properties, Sports, CrossFit training
Abstract: Özet CrossFit Antrenmanlarının Kadın ve Erkek Sedanter Bireylerde Biyokimyasal Parametrelere Etkisi Üzerine Etkisi Öğrencinin Adı: Mervan Kaygu Danışmanı: Doç. Dr. İ. Banu Ayça Anabilim Dalı: Beden Eğitimi ve Spor Anabilim Dalı / Spor Sağlık Programı Amaç: 8 haftalık CrossFit antrenman yoğunluğunun kadın ve erkek bireylerde biyokimyasal parametrelerden; CK(CPK), CK-MB, CRP, protein, albumin, kreatinin, LDH, GGT, ALT, Kolesterol, HDL-K., LDL-K., trigliserit, kalsiyum, magnezyum, çinko, potasyum, sodyum ve vücut ağırlıklarında oluşabilecek değişimler incelenmiştir. Gereç ve Yöntem: Bu çalışmada yaşları 20- 40 yıl arasında olan 12 kadın ve 12 erkek toplam 24 bireyde 8 haftalık CrossFit antrenmanları yaptırılmıştır. Antrenman süreleri 90 dakika olarak belirlenmiştir. Katılımcılar her hafta 3 gün (Pazartesi, Çarşamba, Cuma) saat 20:00-21:30 arasında antrenman yaptırılmıştır. Katılımcılardan antrenman programlardan bir gün önce ve bir gün sonra sabah 09:00 iki defa kan alımı yapılmıştır. Örnekler ön-son test ile karşılaştırılmıştır. Sonuçlar: Antrenman öncesi ve sonrası deneklerin vücut ağırlığı ve BMI incelendiğinde; kadın ve erkek deneklerde ilk ölçüme göre son ölçüm vücut ağırlıklarında düşüş istatistiksel olarak anlamlı bulunmuştur. Biyokimyasal parametrelere bakıldığında CPK, CK-MB, Sodyum ölçümlerinde anlamlı artış, çinko, HDL-K ölçümlerinde anlamlı düşüş, CRP, Protein, GGT, ALT, LDH, Kreatinin, Albümin, Magnezyum, Potasyum, Kalsiyum, Kolesterol, LDL-K ve Trigliserid ölçümlerindeki değişim istatistiksel olarak anlamlı bulunmamıştır. Erkek deneklerde CK-MB, ALT, magnezyum, ölçümlerinde anlamlı artış, kalsiyum, Çinko, HDL-K ölçümlerinde anlamlı azalma, CPK, CRP, Protein, GGT, LDH, Kreatinin, Albümin, Potasyum, Kolesterol, LDL-K ve Trigliserid ölçümlerindeki değişim istatistiksel olarak anlamlı bulunmamıştır. Anahtar Kelimeler: Crossfit, Sağlık, Spor, Biyokimyasal parametreler Summary Effects of CrossFit Training on Effects of Biochemical Parameters in Female and Male Sedentary Individuals Student’s Name/Surname: Mervan Kaygu Adviser: Assoc. Prof. Dr. I. Banu Ayca Department: Depertmen of Physical Education and Sports/Sports Health Program Objective: The aim of this study is to investigate the changes CK(CPK), CK-MB, CRP, protein, albumin, creatinine, LDH, GGT, ALT, cholesterol, HDL-C, LDL-C, triglycerides, calcium, magnesium, zinc, potassium, sodium levels and body weight with 8-week CrossFit training intensity of male and female individuals in biochemical parameters. Materials/Methods: In this study, 24 participants (12 females and 12 males) who aged between 20 and 40 were trained 8-weeks CrossFit program. Training times were set up 90 minutes. The participants were trained 3 days in every week (Monday, Wednesday, Friday) between 20:00-21:30. The participants gave blood twice, one day before the training program at 09:00 A.M. and one day after the 8-week CrossFit training program was completed at 09:00 A.M. Results: When the body weight and BMI of the participants were analyzed before and after training, the decrease in body weight measurements was statistically found significant in participants compared to the first measurement. When biochemical parameters were examined, there was a significiant increase in CPK, CK-MB, sodium measurements; a significant decrease in HDL-C, zinc measurements and changes in CRP, protein, GGT, ALT, LDH, creatinine, albumin, magnesium, potassium, calcium, cholesterol, LDL-C and triglyceride measurements were not statistically found significant. In male participants, there was a significant increase in CK-MB, ALT, magnesium; a significant decrease in calcium, zinc, HDL-C. Changes in CPK, CRP, Protein, GGT, LDH, creatinine, albumin, potassium, cholesterol, LDL-C and triglycerides were not statistically found significant. Key Words: Crossfit, Health, Sport, Biochemical parameters
Published: 2019

45. Dans sporcularının fizyolojik ve biyokimyasal parametrelerinin belirlenmesi

Author: Güvenç, Burcu, Ayça, İ Banu, and Beden Eğitimi ve Spor Anabilim dalı
Subjects: Spor, Beden eğitimi
Published: 2013

46. Determining nutritional behaviour of 10-14 age group children from different sportive branches

Author: Şirinoğlu, Volkan, Ayça, İ Banu, Beden Eğitimi ve Spor Anabilim Dalı, and Ayça, İnci Banu
Subjects: Spor, Nutrition and Dietetics, Nutrition education, Beden Eğitimi ve Spor, Beslenme Alışkanlıkları, Beslenme ve Diyetetik, Sports, Nutrition
Abstract: ÖZETÇalışma, 10-14 yaş grubu farklı spor branşlarındaki çocukların beslenme alışkanlıklarının belirlenmesi amacı ile yapılmıştır. Çalışmanın sonunda bu yaş grubundaki çocuk sporcuların bilinçli ve dengeli beslenmeleri konusunda rol oynayan unsurların belirlenmesi hedeflenmiştir. Araştırma 10-14 yaş grubu Voleybol, Basketbol, Tenis, Yüzme, Sutopu, Atletizm branşlarında spor yapan toplam 260 çocuk üzerinde gerçekleştirilmiştir. Sporculara 47 sorudan oluşan içeriğinde kendisinin, ailesinin, antrenörünün beslenme bilgi düzeylerini ölçmeye ve sporcuların besin desteği vitamin ve enerji içeceği kullanma alışkanlıklarını değerlendirmeye yönelik anket soruları verilmiştir, söz konusu anket içeriğinde yine sporcuların besin tüketim durumlarını tespit etmek amacıyla 3 günlük besin tüketim kaydının yapılacağı besin tüketim çizelgesi kullanılmıştır. Anket formları aracılığıyla elde edilen bilgiler SPSS (Statistical Package for Social Sciences) 16.0 paket programı, enerji ve besin öğesi alımının değerlendirilmesinde de cinsiyet ve yaşa göre günlük alımı önerilen RDA değerleri kullanılmıştır.Sporculardan beslenme bilinci yüksek olanların yine beslenme bilinci yüksek olan ailelerden geldikleri ve beslenme bilinci yüksek olan antrenörler tarafından çalıştırıldıkları belirlenmiştir. En yüksek beslenme bilincine sahip olan antrenörlerin ise Yüzme antrenörleri olduğu tespit edilmiştir. Güçlü beslenme bilincine sahip aileleri olan sporcuların aynı zamanda güçlü beslenme bilincine sahip antrenörleri olduğu da gözlemlenmiştir. Normalin üzerinde kalsiyum tüketiminin de yüksek beslenme bilinci olan bir aileye sahip olmak ile ilişkili olduğu bulgulanmıştır. Sporcuların, ailelerinin ve antrenörlerinin iyi beslenmenin aşırı beslenme demek olmadığı konusunda aydınlatılmalarında yarar görülebilir. SUMMARY DETERMINING NUTRTIONAL BEHAVIOUR OF 10-14 AGE GROUP CHILDREN FROM DIFFERENT SPORTIVE BRANCHESThis thesis is done for learning feeding habit of children between 10-14 ages who are doing different sports. As a result of this thesis, target is importance of conscious and well-balanced feeding and why it is significant for young athletes at these ages. This research is done on children who play volleyball, basketball, tennis, swimming, water polo between 10-14 ages. The total number of children is 260. 47 questions are asked the young sportsmen which contain themselves and their families and their coach knowledge about stable feeding and taking vitamins and energy drinks. Moreover, young athletes feeding habit should be known, so food consumption has been recorded for three days. These results are recorded to computer by SPSS (Statistical Package for Social Sciences) 16.0 package program, finally young athletes RDA values corresponding to their ages and genders are used.It is determined that if nutrition consciousness of their families and their coaches is high, young athletes nutrition consciousness are similar to them. Swimming coaches have the best idea about nutrition. If the athletes have families which are strong food ability, their coaches will be strong as their families. So much calcium is consumed by athletes whose families have got high conscious about food ability. Athletes and their family should be warned to take overrate calorie.
Published: 2008

47. Safety and Pharmacokinetics of Nirsevimab in Immunocompromised Children.

Author: Domachowske J, Hamrén UW, Banu I, Baronio R, Basavaraju B, Koen A, Leach A, Mankad VS, Pannaraj PS, Soler-Palacin P, Takas T, Mori M, and Villafana T
Subjects: Humans, Male, Female, Infant, Injections, Intramuscular, Antiviral Agents pharmacokinetics, Antiviral Agents therapeutic use, Antiviral Agents adverse effects, Antiviral Agents administration & dosage, Child, Preschool, Immunocompromised Host, Respiratory Syncytial Virus Infections drug therapy, Antibodies, Monoclonal, Humanized pharmacokinetics, Antibodies, Monoclonal, Humanized therapeutic use, Antibodies, Monoclonal, Humanized adverse effects
Abstract: Background and Objectives: Immunocompromised children may have increased risk for severe respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI), potentially leading to prolonged hospitalization, intensive care, and death. The open-label phase II MUSIC trial evaluated the safety and pharmacokinetics of nirsevimab, an extended half-life monoclonal antibody against RSV, in immunocompromised children aged ≤24 months., Methods: Participants received a single intramuscular injection of nirsevimab (first RSV season: 50 mg if <5 kg/100 mg if ≥5 kg; second season: 200 mg). Safety, antidrug antibodies, and pharmacokinetics were evaluated to day 361., Results: Participants (n = 100) had ≥1 immunocompromising conditions: primary immunodeficiency (n = 33), previous transplantation (n = 16), HIV infection (n = 8) or treatment with high-dose systemic corticosteroids (n = 29), immunosuppressive chemotherapy (n = 20), or other immunosuppressive therapies (n = 15). Six children experienced eight treatment-related adverse events (none categorized as serious). Three deaths occurred, all were unrelated to treatment. Eleven children, developed antidrug antibodies, with minimal effects on pharmacokinetics and no apparent impact on safety. Nirsevimab serum concentrations at day 151 were similar to those effective in preventing medically attended RSV LRTI in healthy infants. Fourteen children had increased nirsevimab clearance. No protocol-defined medically attended RSV LRTIs occured through day 151., Conclusions: Among immunocompromised children aged ≤24 months, nirsevimab was well tolerated with no safety concerns and serum concentrations were supportive of efficacy. A subset of children with increased nirsevimab clearance, had conditions potentially associated with protein loss; however, the impact on efficacy is unknown.
Published: 2024
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48. Advances in Understanding the Antioxidant and Antigenic Properties of Egg-Derived Peptides.

Author: Brumă Călin M, Vasilean I, Grigore-Gurgu L, Banu I, and Aprodu I
Subjects: Trypsin, Endopeptidase K, Peptides chemistry, Egg Proteins chemistry, Hydrolysis, Immunoglobulin E, Protein Hydrolysates chemistry, Antioxidants chemistry, Pepsin A
Abstract: Pepsin, trypsin and proteinase K were used in the present study to hydrolyse the proteins from whole eggs, yolks or whites, and the resulting hydrolysates were characterised in terms of antioxidant and IgE-binding properties, using a combination of in vitro and in silico methods. Based on the degree of hydrolysis (DH) results, the egg yolk proteins are better substrates for all the tested enzymes (DH of 6.2-20.1%) compared to those from egg whites (DH of 2.0-4.4%). The SDS-PAGE analysis indicated that pepsin and proteinase K were more efficient compared to trypsin in breaking the intramolecular peptide bonds of the high molecular weight egg proteins. For all the tested substrates, enzyme-assisted hydrolysis resulted in a significant increase in antioxidant activity, suggesting that many bioactive peptides are encrypted in inactive forms in the parent proteins. The hydrolysates obtained with proteinase K exhibited the highest DPPH radical scavenging activity (124-311 µM Trolox/g protein) and the lowest residual IgE-binding capacity. The bioinformatics tools revealed that proteinase K is able to break the integrity of the main linear IgE-binding epitopes from ovalbumin and ovomucoid. It can be concluded that proteinase K is a promising tool for modulating the intrinsic properties of egg proteins.
Published: 2024
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49. Insulin analogs as an add-on to metformin after failure to oral treatment in type 2 diabetic patients increase diastole duration. The INSUlin Regimens and VASCular Functions (INSUVASC) study.

Author: Fysekidis M, Cosson E, Sabouret P, Takbou K, Sutton A, Charnaux N, Banu I, Testa A, Biondi-Zoccai G, Vicaut E, and Valensi P
Subjects: Female, Humans, Adult, Middle Aged, Male, Insulin therapeutic use, Insulin adverse effects, Pulse Wave Analysis, Diastole, Insulin, Regular, Human therapeutic use, Metformin therapeutic use, Metformin adverse effects, Diabetes Mellitus, Type 2 drug therapy, Diabetes Mellitus, Type 2 chemically induced
Abstract: Background: Fast acting insulin analogues are known to improve arterial stiffness. The combination of metformin with insulin represents a widely used therapeutic strategy in diabetes. We hypothesized that insulin treatment in patients with type 2 diabetes (T2D) with long-acting, fast-acting or basal bolus insulin as an add-on to metformin would provide additional improvement of arterial stiffness., Methods: The INSUlin Regimens and VASCular Functions (INSUVASC) study is a pilot, randomized, open label three-arms study that included 42 patients with type 2 diabetes (T2D) in primary prevention, after a failure to oral antidiabetic agents. Arterial stiffness measurements were performed at fasting and after a standardized breakfast. During the first visit (V1) pre-randomization, participants took only metformin to perform the tests. The same tests were repeated after 4 weeks of insulin treatment during the second visit (V2)., Results: Data were available for final analysis in 40 patients, with a mean age of 53.6±9.7 years and a mean duration of diabetes of 10.6±5.6 years. Twenty-one were females (52.5%), hypertension and dyslipidemia were present in 18 (45%) and 17 patients (42.5%), respectively. After insulin treatment, the metabolic control was associated to a decrease in oxidative stress and improvement of endothelial functions, with a post prandial diastole duration increased and a decrease of the peripheral arterial stiffness, with a better post prandial pulse pressure ratio and ejection duration after insulin. In hypertensive patients, insulin treatment provided positive effects by decreasing the pulse wave velocity and improving reflection time., Conclusions: A short time treatment by insulin in addition to metformin improved myocardial perfusion. Moreover, insulin treatment in hypertensive patients provides a better hemodynamic profile in large arteries.
Published: 2023
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50. Safety of Re-dosing Nirsevimab Prior to RSV Season 2 in Children With Heart or Lung Disease.

Author: Domachowske JB, Chang Y, Atanasova V, Cabañas F, Furuno K, Nguyen KA, Banu I, Kubiak RJ, Leach A, Mankad VS, Shroff M, Takas T, Villafana T, and Wählby Hamrén U
Subjects: Infant, Child, Humans, Antibodies, Monoclonal, Antiviral Agents therapeutic use, Seasons, Respiratory Syncytial Virus Infections drug therapy, Respiratory Syncytial Virus Infections epidemiology, Respiratory Syncytial Virus, Human, Lung Diseases drug therapy
Abstract: In children with congenital heart disease and/or chronic lung disease entering their second respiratory syncytial virus (RSV) season, 200 mg nirsevimab had a similar safety profile to that of palivizumab and resulted in nirsevimab serum exposures associated with efficacy in healthy infants, supporting efficacy in this population at risk of severe RSV disease., (© The Author(s) 2023. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society.)
Published: 2023
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