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5 results on '"I.C. Stewart"'

1. Early cellular reactions induced by dinitrochlorobenzene in sensitized human skin

Author

James A. Ross, D.J. Gawkrodger, J.A.A. Hunter, Eva McVittie, P.A. Botham, M.M. Carr, and I.C. Stewart

Subjects
Male, Pathology, medicine.medical_specialty, Allergy, Time Factors, Langerhans cell, Fluorescent Antibody Technique, Human skin, Dermatology, Dermatitis, Contact, Immunoenzyme Techniques, Dermis, Immunopathology, Biopsy, Dinitrochlorobenzene, medicine, Humans, Nitrobenzenes, Aged, Skin, medicine.diagnostic_test, business.industry, Antibodies, Monoclonal, Skin test, Middle Aged, Patch Tests, medicine.disease, medicine.anatomical_structure, Langerhans Cells, Female, business, Contact dermatitis
Abstract

SUMMARY Serial biopsies during the first 24 hours after dinitrochlorobenzene (DNCB) challenge in fifteen sensitized patients have shown that DNCB associates with Langerhans cells within 1 hour of application, and has reached the dermis around the appendages by 6 hours.

Published
1984
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2. Erythromycin in the management of troublesome BCG lesions

Author

I.C. Stewart, J.D. Ross, and J.T. Power

Subjects
Pulmonary and Respiratory Medicine, Chemotherapy, medicine.medical_specialty, business.industry, medicine.drug_class, medicine.medical_treatment, Antibiotics, Erythromycin, complex mixtures, Surgery, Internal medicine, Toxicity, Medicine, business, medicine.drug
Abstract

We have recently seen six persons with troublesome post-BCG lesions. All lesions healed whilst on therapy with erythromycin for a period of 2–4 weeks. Erythromycin has some effect on the atypical mycobacteria (Wolinsky et al. 1957) but its use has not previously been described for treatment of BCG lesions.

Published
1984
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3. Contributors

Author

A.R. Ahmed, M.H. Allen, P.L. Amlot, C.B. Archer, F. Ayala, Marie Anne Bach, B.S. Baker, C. Berger, E. Berti, B. Bhogal, J.R. Bjerke, M.M. Black, E. Bonifazi, K. Bork, J.D. Bos, P.A. Botham, A. Bourland, O. Braun-Falco, J. Brochier, Eva-B. Bröcker, J. Brüggen, B.E. Buck, G. Budillon, G. Burg, T.K. Burnham, J.G. Camarasa, R. Caputo, M.M. Carr, A. Cats, S. Cavicchini, D.V. Chapman, E. Christophers, J.C. Claudatus, G. Cordier, F. Cottenot, Marie Cramers, R. Cuomo, M. Cusini, Beate M. Czarnetzki, J. Czernielewski, M.R. Daha, M.C.J.M. De Jong, G.F. Del Prete, M. Demarchez, J.A.M. De Nijs, G. De Panfilis, U. Detmar, C. Dezutter-Dambuyant, D. Djawari, K. Donhuijsen, L. Dubertret, R. Edelson, H. Ely, J.A. Emsbroek, A. Fattorossi, M. Faure, Beatrice Flageul, M. Fosse, A. Frappez, W. Freytag, L. Fry, P. Garcia Calderón, M. Gaucherand, D.J. Gawkrodger, W. Gebhart, B. Giannotti, J. Grabbe, R.M. Graham, B. Gretenkord, H. Hauck, E. Haneke, R. Happle, L.C. Harber, R.H. Heinzerling, T. Herlin, E. Heyderman, Suzanne Hobbs, E.J. Holborow, C.A. Holden, R.C. Holmes, J.J. Horton, J.A.A. Hunter, J. Hutterer, P.G. Isaacson, H. Ishikawa, O. Ishikawa, D.C.O. James, J. Jensen, Michaela Jung, L. Kanerva, Arja-Leena Kariniemi, P. Kaudewitz, D.M. Kemeny, P. Kind, D'Anne M. Kleinsmith, J. Knop, M. Kohda, Recia Kott Blumenkranz, D. Kraft, K. Kragballe, S.R. Krieg, H.K. Krogh, J.M. Lachapelle, C. Laquoi, H. Lassmann, J. Lauharanta, L.-D. Leder, H. Leibl, G. Lembo, J.N. Leonard, M.H. Lessof, E. Linder, D.A. McCarthy, E. Macher, P.H. McKee, E. McVittie, M. Mardin, R.A. Marsden, D.Y. Mason, R. Matre, C.J.L.M. Meijer, C.L. Meneghini, M. Monti, J. Morley, S. Moretti, B. Morsches, S. Mynttinen, M. Nadji, Kirsti-Maria Niemi, D.A. Norris, C.P. Page, M.G. Paindelli, A. Palermo, P.E. Parkes, F. Parolini, G. Parrilli, J.M. Pelachyk, N.S. Penneys, Ch. Perret, K. Pihlman, M. Plosila, L.W. Poulter, F.C. Powell, C. Prost, M. Prunieras, Annamari Ranki, I. Rantala, T. Reunala, T.C. Richardson, P. Rieber, N. Romani, J.A. Ross, D.J. Ruiter, H. Rumpold, R. Russell-Jones, P. Santoianni, M. Santucci, E. Scheffer, H.-E. Schlaak, D. Schmitt, R.E. Schopf, T. Schrenker, J.-M. Schröder, A.L. Schroeter, Ch. Schubert, G. Schuler, S. Schuller-Petrovic, R. Serri, M. Simon, N.P. Smith, C. Sorg, J. Spaull, M.J. Staquet, I.C. Stewart, G. Stingl, S. Stubb, L. Suter, A.F. Swain, U. Taborsky, T. Tamura, S. Ternowitz, K. Thestrup-Pedersen, J. Thivolet, R. Touraine, E. Tschachler, D. Tuffanelli, D.J. Unsworth, Helgi Valdimarsson, J.B. Van der Meer, W.A. van Vloten, B.J. Vermeer, E. Vesterinen, J. Viac, A. Villa, T. Wahlström, D. Wallach, M.L. Westedt, L. Wiesner-Menzel, R. Willemze, Fenella Wojnarowska, K. Wolff, H. Zachariae, and C.B. Zachary

Published
1984
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4. Cellular events in human skin after challenge with dinitrochlorobenzene

Author

D. J. Gawkrodger, J. A. A. Hunter, E. McVittie, P.A. Botham, James A. Ross, M.M. Carr, and I.C. Stewart

Subjects
Cell type, Pathology, medicine.medical_specialty, Epidermis (botany), business.industry, Patch test, Human skin, Bronchogenic carcinoma, Apposition, medicine.anatomical_structure, Dermis, Immunology, medicine, business, Sensitization
Abstract

Publisher Summary This chapter presents a study analyzing cellular events in human skin after application of dinitrochlorobenzene (DNCB). Fifteen subjects were studied—2 healthy volunteers and 13 patients with bronchogenic carcinoma. These patients entered the study at the time of diagnosis and all were ambulant, hematologically normal, and had a normal clinical sensitization reaction to DNCB. Sensitization was achieved with an occlusive patch test containing 100 μg DNCB, and the challenge procedure was similarly carried out at least 2 weeks later using 40 μg DNCB on forearm skin. Biopsies were taken from unchallenged skin of each subject (time 0) and from challenge sites at 1, 3, 6, 12, or 24 h after application of the patch. Serial sections have not revealed a close relationship between Langerhans cells and T lymphocytes during the challenge period. No apposition of these cell types was seen by electron microscopy before 12 h, and very few cells were apposed in either the epidermis or dermis at 12 or 24 h.

Published
1984
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5. Experimental Contact Dermatitis Using 2,4-Dinitrochlorobenzene in Humans

Author

P.A. Botham, E. McVittie, J. A. A. Hunter, D. J. Gawkrodger, James A. Ross, M.M. Carr, and I.C. Stewart

Subjects
medicine.medical_specialty, education.field_of_study, business.industry, Population, Alopecia areata, medicine.disease, Dermatology, Bronchogenic carcinoma, 2,4-Dinitrochlorobenzene, chemistry.chemical_compound, chemistry, Hand eczema, medicine, Industrial dermatitis, education, business, Contact dermatitis
Abstract

Contact dermatitis, due to both allergenic (sensitising) and irritant (non-sensitising) agents is a major clinical problem in industry and the home. Although its prevalence in a population depends on the nature of employment and industry, and environmental factors, it has been shown that one type of contact dermatitis alone, hand eczema, affects 2% of men and 3% of women [1]. Industrial dermatitis in fact accounts for about 65% of all spells of absence from work in the United Kingdom recorded under prescribed diseases [9].

Published
1986
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