Search

This paper provides the findings from an integrated diagnostic assessment of first-to-fourth-year pedagogics students' social-perceptive attitudes toward the chosen profession and their personal characteristics linked with those attitudes. The authors have explored students' understanding of the reasons behind the choice of the profession and some of the key factors for the profession's attractiveness and unattractiveness and traced the dynamics of the intensity of their professional orientation. The work has investigated the correlation between pedagogics students' social-perceptive attitudes toward the pedagogical profession and their personal characteristics such as self-efficacy assessments, self-attitude, self-organization, perfectionism, tolerance of uncertainty, and perception of the time perspective. The authors have found that among the key reasons behind students' choice of the pedagogical profession are their childhood dream to become a pedagogue, the profession's alignment with their character, and their pursuit of self-actualization goals through it. Their realization of the reasons changes from their childhood dream (first year) to alignment with their character (second year), to pursuit of self-actualization goals (third year), and to opportunity to spend their time usefully and understand better what they want to be (fourth year). That is, many high school graduates are not fully prepared for making a conscious, responsible choice of the pedagogical profession and tend to start conceptualizing the made choice only in their graduation year. Among the key factors for the pedagogical profession's attractiveness are opportunity to self-improve, opportunity to work with people, and alignment with one's potential and character. The unattractiveness factors include low pay, emotional and physical strains, and the job's low social status. The degree of future pedagogues' professional orientation gradually increases from first to third years and decreases by fourth year. There is a positive correlation between a high level of orientation toward the pedagogical profession and the following personal characteristics of students: a sense of their own self-efficacy; belief in the world's benevolence; realization of responsibility for their own actions in life and their personally significant choices; other-oriented perfectionism; tolerance of uncertainty; positive perception of the past and hedonistic and fatalistic perception of the present; global self-attitude (self-respect, self-affection, and self-interest); high degree of self-organization (goal-orientedness, perseverance, and orientation toward the present). The study's findings indicate that school students ought to be purposefully prepared for the choice of the pedagogical profession. During the period of college preparation of pedagogues, special attention ought to be devoted to organizing on-the-job and pre-graduation practical training in the graduation year. Classes and practical sessions ought to incorporate training sessions on boosting self-efficacy and self-organization, fostering a positive self-concept and a positive perception of the world, and cultivating the ability to anticipate and relieve emotional tension.

The 17th International HLA and Immunogenetics Workshop (IHIW) organizers conducted a Pilot Study (PS) in which 13 laboratories (15 groups) participated to assess the performance of the various sequencing library preparation protocols, NGS platforms and software in use prior to the workshop. The organizers sent 50 cell lines to each of the 15 groups, scored the 15 independently generated sets of NGS HLA genotyping data, and generated "consensus" HLA genotypes for each of the 50 cell lines. Proficiency Testing (PT) was subsequently organized using four sets of 24 cell lines, selected from 48 of 50 PS cell lines, to validate the quality of NGS HLA typing data from the 34 participating IHIW laboratories. Completion of the PT program with a minimum score of 95% concordance at the HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 loci satisfied the requirements to submit NGS HLA typing data for the 17th IHIW projects. Together, these PS and PT efforts constituted the 17th IHIW Quality Control project. Overall PT concordance rates for HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4 and HLA-DRB5 were 98.1%, 97.0% and 98.1%, 99.0%, 98.6%, 98.8%, 97.6%, 96.0%, 99.1%, 90.0% and 91.7%, respectively. Across all loci, the majority of the discordance was due to allele dropout. The high cost of NGS HLA genotyping per experiment likely prevented the retyping of initially failed HLA loci. Despite the high HLA genotype concordance rates of the software, there remains room for improvement in the assembly of more accurate consensus DNA sequences by NGS HLA genotyping software.

For the management of information flow, the use of the functional modelling methodology is proposed, as part of the graph theory for describing the functioning of systems, such as public authorities as organizational-management structures. The methodology is based on concepts such as functional block and interface arc (flow). In organizational-management structures, one of the functional blocks is the manager, and the others are managed. Each of the blocks is a source of information and generates information flows, transferring information to a managed functional block or several ones. For the implementation and management of information exchange by the public authorities in crisis management, processing and protection of data flow, when working in a group environment, it is proposed to build an adequate communication and information system using the methodology of functional modelling. [ABSTRACT FROM AUTHOR]

For the management of information flow, the use of the functional modelling methodology is proposed, as part of the graph theory for describing the functioning of systems, such as public authorities as organizational-management structures. The methodology is based on concepts such as functional block and interface arc (flow). In organizational-management structures, one of the functional blocks is the manager, and the others are managed. Each of the blocks is a source of information and generates information flows, transferring information to a managed functional block or several ones. For the implementation and management of information exchange by the public authorities in crisis management, processing and protection of data flow, when working in a group environment, it is proposed to build an adequate communication and information system using the methodology of functional modelling. [ABSTRACT FROM AUTHOR]

The novel MICA*112:02 allele was detected by next generation sequencing. [ABSTRACT FROM AUTHOR]

Two novel MICB alleles with coding polymorphisms in exon 3 were detected by next generation sequencing. [ABSTRACT FROM AUTHOR]

The presented study revealed that there were changes in the phenolic compounds profile of extract of wild thyme (Thymus serpyllum L.) after γ-irradiation at the dose of 5 kGy. Ethanolic extracts of irradiated and non-irradiated herb were prepared and their compounds were analyzed by RP-HPLC-DAD technique. Between thirty two detected constituents, twelve phenolic compounds classified as hydroxybenzoic and hydroxycinnamic acids derivatives, flavones and flavanones were identified. Among them, caffeic acid derivatives and flavones predominated with the highest content of rosmarinic acid and luteolin-7-O-glucoside, respectively. Additionally, thymol was recognized in the analyzed extracts. γ-Irradiation slightly affected the quantitative profile of phenolic compounds of a wild thyme ethanolic extract. Only four constituents differed significantly (P

JAK2 V617F‐driven myeloproliferative neoplasms (MPNs) can escape immune surveillance through PD‐L1 up‐regulation and HLA class I pathway down‐regulation. To complement these data we assessed the role of major histocompatibility complex class I—related genes (MICA and MICB) in JAK2 V617F+ MPNs. Using high resolution genotyping we identified two protective alleles, MICA*008:01 and MICA*016. MPN patients had significantly higher levels of soluble sMICA molecules. Peripheral blood JAK2 V617F+ granulocytes had higher surface expression of MICB but did not differ in the amount of MICA and MICB transcripts from normal granulocytes. MICA and MICB genes were significantly down‐regulated in JAK2 V617F+ CD34+ cells from primary myelofibrosis patients in comparison to normal CD34+ hematopoietic stem cells. These data suggest minor but significant role of MICA and MICB genes in the pathogenesis of MPNs. It is also possible that MICA targeting approaches could be of clinical benefit for some of those patients. [ABSTRACT FROM AUTHOR]