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2. Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia

Author

Stefano Zucchini, Stefano Tumini, Andrea Enzo Scaramuzza, Riccardo Bonfanti, Maurizio Delvecchio, Roberto Franceschi, Dario Iafusco, Lorenzo Lenzi, Enza Mozzillo, Stefano Passanisi, Claudia Piona, Ivana Rabbone, Novella Rapini, Andrea Rigamonti, Carlo Ripoli, Giuseppina Salzano, Silvia Savastio, Riccardo Schiaffini, Angela Zanfardino, Valentino Cherubini, Diabetes Study Group of the Italian Society for Pediatric Endocrinology Diabetes, Albino Claudia Accursia, Aloe Monica, Anzelotti Maria Teresa, Arnaldi Claudia, Barbetti Fabrizio, Bassi Marta, Berioli Maria Giulia, Bernardini Luca, Bertelli Enrica, Biagioni Martina, Bobbio Adriana, Bombaci Bruno, Bonfanti Riccardo, Bonura Clara, Bracciolini Giulia Patrizia, Bruzzese Mariella, Bruzzi Patrizia, Buono Pietro, Buscarino Piera, Cadario Francesco, Calcaterra Valeria, Calzi Elena, Cappa Marco, Cardani Roberta, Cardella Francesca, Cardinale Giuliana Marcella, Casertano Alberto, Castorani Valeria, Cauvin Vittoria, Cenciarelli Valentina, Ceruti Franco, Cherubini Valentino, Chiarelli Francesco, Chiari Giovanni, Cianfarani Stefano, Cicchetti Mario, Cipriano Paola, Cirillo Dante, Citriniti Felice, Coccioli Maria Susanna, Confetto Santino, Contreas Giovanna, Coro Anna, Correddu Antonella, Corsini Elisa, Crino’ Antonino, d’Annunzio Giuseppe, De Berardinis Fiorella, De Donno Valeria, De Filippo Gianpaolo, De Marco Rosaria, De Sanctis Luisa, Del Duca Elisabetta, Delvecchio Maurizio, Deodati Annalisa, Di Bonito Procolo, Di Candia Francesca, Faleschini Elena, Fattorusso Valentina, Favia Anna, Federico Giovanni, Felappi Barbara, Ferrari Mara, Ferrito Lucia, Fichera Graziella, Fontana Franco, Fornari Elena, Franceschi Roberto, Franco Francesca, Franzese Adriana, Frongia Anna Paola, Frontino Giulio, Gaiero Alberto, Galassi Sabrina Maria, Gallo Francesco, Gargantini Luigi, Giani Elisa, Gortan Anna Jolanda, Graziani Vanna, Grosso Caterina, Gualtieri Antonella, Guasti Monica, Guerraggio Lucia Paola, Guzzetti Chiara, Iafusco Dario, Iannicelli Gennaro, Iezzi Maria Laura, Ignaccolo Maria Giovanna, Innaurato Stefania, Inzaghi Elena, Iovane Brunella, Iughetti Lorenzo, Kaufmann Peter, La Loggia Alfonso, Lambertini Anna Giulia, Lapolla Rosa, Lasagni Anna, Lazzaro Nicola, Lazzeroni Pietro, Lenzi Lorenzo, Lera Riccardo, Levantini Gabriella, Lezzi Marilea, Lia Rosanna, Liguori Alice, Lo Presti Donatella, Lombardo Fortunato, Lonero Antonella, Longhi Silvia, Lorubbio Antonella, Lucchesi Sonia, Maccioni Rosella, Macedoni Maddalena, Macellaro Patrizia Cristiana, Madeo Simona Filomena, Maffeis Claudio, Mainetti Benedetta, Maltoni Giulio, Mameli Chiara, Mammì Francesco, Manca Bitti Maria Luisa, Mancioppi Valentina, Manco Melania, Marigliano Marco, Marino Monica, Marsciani Alberto, Matteoli Maria Cristina, Mazzali Elena, Minute Marta, Minuto Nicola, Monti Sara, Morandi Anita,, Morganti Gianfranco, Morotti Elisa, Mozzillo Enza, Musolino Gianluca, Olivieri Francesca, Ortolani Federica, Pampanini Valentina, Pardi Daniela, Pascarella Filomena, Pasquino Bruno, Passanisi Stefano, Patera Ippolita Patrizia, Pedini Annalisa, Pennati Maria Cristina, Peruzzi Sonia, Peverelli Paola, Pezzino Giulia, Piccini Barbara, Piccinno Elvira Eugenia Rosaria, Piona Claudia, Piredda Gavina, Piscopo Alessia, Pistone Carmelo, Pozzi Erica, Prandi Elena, Predieri Barbara, Prudente Sabrina, Pulcina Anna, Rabbone Ivana, Randazzo Emioli, Rapini Novella, Reinstadler Petra, Riboni Sara, Ricciardi Maria Rossella, Rigamonti Andrea, Ripoli Carlo, Rossi Virginia, Rossi Paolo, Rutigliano Irene, Sabbion Alberto, Salvatoni Alessandro, Salvo Caterina, Salzano Giuseppina, Sanseviero Mariateresa, Savastio Silvia, Savini Rosanna, Scanu Mariapiera, Scaramuzza Andrea Enzo, Schiaffini Riccardo, Schiavone Maurizio, Schieven Eleonardo, Scipione Mirella, Secco Andrea, Silvestri Francesca, Siri Giulia, Sogno Valin Paola, Sordelli Silvia, Spiri Daniele, Stagi Stefano, Stamati Filomena Andreina, Suprani Tosca, Talarico Valentina, Tiberi Valentina, Timpanaro Tiziana Antonia Lucia, Tinti Davide, Tirendi Antonina, Tomaselli Letizia Grazia, Toni Sonia, Torelli Cataldo, Tornese Gianluca, Trada Michela,, Trettene Adolfo Andrea, Tumini Stefano, Tumminelli Marilena, Valerio Giuliana, Vandelli Sara, Ventrici Claudia, Zampolli Maria, Zanatta Manuela, Zanfardino Angela, Zecchino Clara, Zonca Silvia, and Zucchini Stefano

Subjects
adolescents, automated insulin delivery, children, hypoglycemia, glucagon, oral glucose, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

There has been continuous progress in diabetes management over the last few decades, not least due to the widespread dissemination of continuous glucose monitoring (CGM) and automated insulin delivery systems. These technological advances have radically changed the daily lives of people living with diabetes, improving the quality of life of both children and their families. Despite this, hypoglycemia remains the primary side-effect of insulin therapy. Based on a systematic review of the available scientific evidence, this paper aims to provide evidence-based recommendations for recognizing, risk stratifying, treating, and managing patients with hypoglycemia. The objective of these recommendations is to unify the behavior of pediatric diabetologists with respect to the timely recognition and prevention of hypoglycemic episodes and the correct treatment of hypoglycemia, especially in patients using CGM or advanced hybrid closed-loop systems. All authors have long experience in the specialty and are members of the Italian Society of Pediatric Endocrinology and Diabetology. The goal of treating hypoglycemia is to raise blood glucose above 70 mg/dL (3.9 mmol/L) and to prevent further decreases. Oral glucose at a dose of 0.3 g/kg (0.1 g/kg for children using “smart pumps” or hybrid closed loop systems in automated mode) is the preferred treatment for the conscious individual with blood glucose

Published
2024
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5. Rare Forms of Early Onset Diabetes

Author

Rabbone, Ivana, Cherubini, Valentino, Franzese, Adriana, Mozzillo, Enza, Tiberi, Valentina, Tinti, Davide, Tripodi, Marina, Zanfardino, Angela, Piscopo, Alessia, Iafusco, Dario, Rabbone, Ivana, editor, and Iafusco, Dario, editor

Published
2023
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8. Italian translation and validation of the CGM satisfaction scale questionnaire

Author

Mozzillo, Enza, Marigliano, Marco, Troncone, Alda, Maffeis, Claudio, Morotti, Elisa, Di Candia, Francesca, Fedi, Ludovica, Iafusco, Dario, Zanfardino, Angela, Cauvin, Vittoria, Pertile, Riccardo, Maltoni, Giulio, Zucchini, Stefano, Cherubini, Valentino, Tiberi, Valentina, Minuto, Nicola, Bassi, Marta, Rabbone, Ivana, Savastio, Silvia, Tinti, Davide, Tornese, Gianluca, Schiaffini, Riccardo, Passanisi, Stefano, Lombardo, Fortunato, Bonfanti, Riccardo, Scaramuzza, Andrea, and Franceschi, Roberto

Published
2023
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10. Satisfaction with continuous glucose monitoring is positively correlated with time in range in children with type 1 diabetes

Author

Marigliano, Marco, Pertile, Riccardo, Mozzillo, Enza, Troncone, Alda, Maffeis, Claudio, Morotti, Elisa, Di Candia, Francesca, Fedi, Ludovica, Iafusco, Dario, Zanfardino, Angela, Cauvin, Vittoria, Maltoni, Giulio, Zucchini, Stefano, Cherubini, Valentino, Tiberi, Valentina, Minuto, Nicola, Bassi, Marta, Rabbone, Ivana, Savastio, Silvia, Tinti, Davide, Tornese, Gianluca, Schiaffini, Riccardo, Passanisi, Stefano, Lombardo, Fortunato, Bonfanti, Riccardo, Scaramuzza, Andrea, and Franceschi, Roberto

Published
2023
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16. Uric acid and cardiometabolic risk by gender in youth with type 1 diabetes

Author

Di Bonito, Procolo, Rosanio, Francesco Maria, Marcovecchio, Maria Loredana, Cherubini, Valentino, Delvecchio, Maurizio, Di Candia, Francesca, Iafusco, Dario, Zanfardino, Angela, Iovane, Brunella, Maffeis, Claudio, Maltoni, Giulio, Ripoli, Carlo, Piccinno, Elvira, Piona, Claudia Anita, Ricciardi, Maria Rossella, Schiaffini, Riccardo, Franzese, Adriana, and Mozzillo, Enza

Published
2022
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19. Follow‐up and monitoring programme in children identified in early‐stage type 1 diabetes during screening in the general population of Italy.

Author

Cherubini, Valentino, Mozzillo, Enza, Iafusco, Dario, Bonfanti, Riccardo, Ripoli, Carlo, Pricci, Flavia, Vincentini, Olimpia, Agrimi, Umberto, Silano, Marco, Ulivi, Francesca, D'Avino, Antonio, Lampasona, Vito, and Bosi, Emanuele

Subjects
TYPE 1 diabetes, MEDICAL screening, CELIAC disease, JUVENILE diseases, PEDIATRICIANS, DIABETIC acidosis, KETOACIDOSIS
Abstract

Aim: To provide guidance for follow‐up and monitoring of children and adolescents identified as positive to islet autoantibodies (IA) in the general population screening for type 1 diabetes (T1D) in Italy. Methods: Detection of IA helps to diagnose pre‐symptomatic T1D, prevent diabetic ketoacidosis (DKA) and identify persons for new therapies to delay symptomatic diabetes. Italy recently became the first country to approve by law a general autoantibody screening program for T1D and celiac disease in all children and adolescents (age 1‐17yr). A pilot study is currently underway in four Italian regions addressing feasibility issues to be used in the scale up to nationwide screening. Meanwhile, a group of experts developed guidance recommendations for follow‐up and monitoring of identified IA positive persons. Results: Ten key components have been identified: establishment of a registry for children and adolescents at risk; close collaboration with the national network of family paediatricians; creation of T1D centers with expertise in follow‐up and monitoring; educational measures; assurance of solid IA tests; identification of appropriate metabolic tests; feed‐back feasibility and acceptability questionnaires; potential access to available therapeutic interventions; valuable outcome measures including DKA incidence; costs monitoring. Distinctive features of this program include single (in addition to multiple) IA antibody‐positive persons in follow‐up and the use of CGM to assess risk progression, rather than the cumbersome OGTT. Conclusion: It is expected that the proposed follow‐up and monitoring program will be effective, affordable and acceptable to children and families identified in general T1D screening in Italy. [ABSTRACT FROM AUTHOR]

Published
2024
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21. The Changing Landscape of Neonatal Diabetes Mellitus in Italy Between 2003 and 2022

Author

Rapini, Novella, Delvecchio, Maurizio, Mucciolo, Mafalda, Ruta, Rosario, Rabbone, Ivana, Cherubini, Valentino, Zucchini, Stefano, Cianfarani, Stefano, Prandi, Elena, Schiaffini, Riccardo, Bizzarri, Carla, Piccini, Barbara, Maltoni, Giulio, Predieri, Barbara, Minuto, Nicola, Di Paola, Rossella, Giordano, Mara, Tinto, Nadia, Grasso, Valeria, Russo, Lucia, Tiberi, Valentina, Scaramuzza, Andrea, Frontino, Giulio, Maggio, Maria Cristina, Musolino, Gianluca, Piccinno, Elvira, Tinti, Davide, Carrera, Paola, Mozzillo, Enza, Cappa, Marco, Iafusco, Dario, Bonfanti, Riccardo, Novelli, Antonio, and Barbetti, Fabrizio

Published
2024
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23. Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia.

Author

Zucchini, Stefano, Tumini, Stefano, Scaramuzza, Andrea Enzo, Bonfanti, Riccardo, Delvecchio, Maurizio, Franceschi, Roberto, Iafusco, Dario, Lenzi, Lorenzo, Mozzillo, Enza, Passanisi, Stefano, Piona, Claudia, Rabbone, Ivana, Rapini, Novella, Rigamonti, Andrea, Ripoli, Carlo, Salzano, Giuseppina, Savastio, Silvia, Schiaffini, Riccardo, Zanfardino, Angela, and Cherubini, Valentino

Subjects
HYPOGLYCEMIA, CONTINUOUS glucose monitoring, CLOSED loop systems, BLOOD sugar, PEOPLE with diabetes, HONEY, FRUIT juices, HYPERGLYCEMIA, SUCROSE
Abstract

There has been continuous progress in diabetes management over the last few decades, not least due to the widespread dissemination of continuous glucose monitoring (CGM) and automated insulin delivery systems. These technological advances have radically changed the daily lives of people living with diabetes, improving the quality of life of both children and their families. Despite this, hypoglycemia remains the primary side-effect of insulin therapy. Based on a systematic review of the available scientific evidence, this paper aims to provide evidence-based recommendations for recognizing, risk stratifying, treating, and managing patients with hypoglycemia. The objective of these recommendations is to unify the behavior of pediatric diabetologists with respect to the timely recognition and prevention of hypoglycemic episodes and the correct treatment of hypoglycemia, especially in patients using CGM or advanced hybrid closedloop systems. All authors have long experience in the specialty and are members of the Italian Society of Pediatric Endocrinology and Diabetology. The goal of treating hypoglycemia is to raise blood glucose above 70 mg/dL (3.9 mmol/L) and to prevent further decreases. Oral glucose at a dose of 0.3 g/kg (0.1 g/kg for children using "smart pumps" or hybrid closed loop systems in automated mode) is the preferred treatment for the conscious individual with blood glucose <70 mg/dL (3.9 mmol/L), although any form of carbohydrate (e.g., sucrose, which consists of glucose and fructose, or honey, sugary soft drinks, or fruit juice) containing glucose may be used. Using automatic insulin delivery systems, the oral glucose dose can be decreased to 0.1 g/kg. Practical flow charts are included to aid clinical decision-making. Although representing the official position of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED), these guidelines are applicable to the global audience and are especially pertinent in the era of CGM and other advanced technologies. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Satisfaction with continuous glucose monitoring is associated with quality of life in young people with type 1 diabetes regardless of metabolic control and treatment type.

Author

Franceschi, Roberto, Pertile, Riccardo, Marigliano, Marco, Mozzillo, Enza, Maffeis, Claudio, Morotti, Elisa, Di Candia, Francesca, Fedi, Ludovica, Iafusco, Dario, Zanfardino, Angela, Cauvin, Vittoria, Maltoni, Giulio, Zucchini, Stefano, Cherubini, Valentino, Tiberi, Valentina, Minuto, Nicola, Bassi, Marta, Rabbone, Ivana, Savastio, Silvia, and Tinti, Davide

Subjects
TYPE 1 diabetes, PARENTS, STATISTICAL correlation, CROSS-sectional method, SATISFACTION, GLYCEMIC control, QUESTIONNAIRES, CAREGIVERS, CONTINUOUS glucose monitoring, QUALITY of life, RESEARCH, PATIENT satisfaction, PATIENTS' attitudes, WELL-being, MEDICAL practice
Abstract

Aims: While continuous glucose monitoring (CGM) and associated technologies have positive effects on metabolic control in young people with type 1 diabetes (T1D), less is known about their impact on quality of life (QoL). Here, we quantified CGM satisfaction and QoL in young people with T1D and their parents/caregivers to establish (i) the relationship between QoL and CGM satisfaction and (ii) the impact of the treatment regimen on QoL. Methods: This was a cross‐sectional study of children and adolescents with T1D on different treatment regimens (multiple daily injections, sensor‐augmented pumps and automated insulin delivery). QoL was assessed with the KINDL instrument, and CGM satisfaction with the CGM‐SAT questionnaire was evaluated in both youths with T1D and their parents. Results: Two hundred and ten consecutively enrolled youths with T1D completed the KINDL and CGM‐SAT questionnaires. The mean total KINDL score was greater than neutral in both subjects with T1D (3.99 ± 0.47) and parents (4.06 ± 0.40), and lower overall CGM‐SAT scores (i.e., higher satisfaction) were significantly associated with higher QoL in all six KINDL subscales (p < 0.05). There were no differences in KINDL scores according to delivery technology or when participants were grouped according to optimal and sub‐optimal glucose control. Conclusions: Higher satisfaction with recent CGMs was associated with better QoL in all dimensions. QoL was independent of both the insulin delivery technology and glycaemic control. CGM must be further disseminated. Attention on perceived satisfaction with CGM should be incorporated with the clinical practice to improve the well‐being of children and adolescents with T1D and their families. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Glycemic Variability and Time in Range Are Associated with the Risk of Overweight and High LDL-Cholesterol in Children and Youths with Type 1 Diabetes

Author

Piona, Claudia, primary, Marigliano, Marco, additional, Mancioppi, Valentina, additional, Mozzillo, Enza, additional, Occhiati, Luisa, additional, Zanfardino, Angela, additional, Iafusco, Dario, additional, Maltoni, Giulio, additional, Zucchini, Stefano, additional, Delvecchio, Maurizio, additional, Passanisi, Stefano, additional, Lombardo, Fortunato, additional, and Maffeis, Claudio, additional

Published
2023
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33. Not Autoimmune Diabetes Mellitus in Paediatrics

Author

Iafusco, Dario, Confetto, Santino, Zanfardino, Angela, Piscopo, Alessia, Casaburo, Francesca, Cocca, Alessandra, Caredda, Elisabetta, Pezzino, Giulia, Tinto, Nadia, Pirozzi, Daniele, Napoli, Angela, Barbetti, Fabrizio, Perrone, Laura, Scaramuzza, Andrea, editor, de Beaufort, Carine, editor, and Hanas, Ragnar, editor

Published
2017
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35. Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study

Author

Aisenberg, Javier, Akkurt, Ilker, Abdul-Latif, Hussein, Al-Abdullah, Anees, Barak, Lubomir, Van Den Bergh, Joop, Bertrand, Anne-Marie, Bizzarri, Carla, Bonfanti, Riccardo, Bruel, Henri, Burrows, Anthony, Cadario, Francesco, Cameron, Fergus J., Carson, Dennis, Cartigny, Maryse, Cauvin, Vittoria, Cave, Helene, Chakera, Ali, Chetan, Ravi, Chiari, Giovanni, Couch, Bob, Coutant, Régis, Cummings, Elizabeth, Dankovcikova, Adriana, Davis, Liz, Deiss, Dorothee, Delvecchio, Maurizio, Faleschini, Elena, Fauret, Anne-Laure, Finn, Roisin, Ford, Tamsin, Franco, Elisa De, Gallen, Bastian De, Gasperíková, Daniela, Guntamukkala, Padma, Hakeem, Vaseem, Hasegawa, Shinji, Hathout, Eba H., Heffernan, Emmeline, Hill, David, Ho, Josephine, Hoarau, Marie, Holl, Reinhard, Hoddinott, Rebecca, Houghton, Jane, Howard, Neville, Hughes, Natalie, Hunter, Ian, Høgåsen, Anne Kirsti, Kuulasmaa, Helena, Ioacara, Sorin, Iotova, Violeta, Irgens, Henrik, Jaap, Alan, Jones, Kenneth, Kapellen, Thomas, Kaufman, Ellen, Klinge, Andreas, Klupa, Tomasz, Krishnaswamy, Ramaiyer, Lafferty, Tony, LeGault, Laurent, Lambert, Paul, Malecki, Maciej T, Malievsky, Olag, Mathew, Revi, Mathews, Frances, McVie, Robert, Menzel, Ulrike, Metz, Chantale, Meulen, John Van Der, Modgil, Gita, Mul, Dick, Muther, Silvia, Nuboer, Roos, O'Connell, Susan M., O'Riordan, Stephen, Palko, Miroslav, Patel, Kashyap Amratlal, Pesavento, Roberta, Piccinno, Elvira, Pillai, Janani Kumaraguru, Pruhova, Stephanka, Punthakee, Zubin, Rabbone, Ivana, Raile, Klemens, Rincon, Marielisa, Rose, Danette, Sanchez, Janine, Sandereson, Susan, Saxena, Vinay, Schebek, Martin, Schmidt, Dorothee, Shehadeh, Naim, Shiels, Julian P.H., Silva, Jose M. C. L, Stanik, Juraj, Tinklin, Tracy, Tjora, Erling, Tumini, Stefano, Tuomi, Tiinamaija, Uehara, Akiko, Velde, Robert Van der, Vermeulen, Guido, Visser, Uma, Voorhoeve, Paul, Walker, Jan, Weill, Jaques, Weisner, Tobias, Werner, Andrea, Williams, Toni, Woodhead, Helen, øddegård, Rønnaug, Bowman, Pamela, Sulen, Åsta, Barbetti, Fabrizio, Beltrand, Jacques, Svalastoga, Pernille, Codner, Ethel, Tessmann, Ellen H, Juliusson, Petur B, Skrivarhaug, Torild, Pearson, Ewan R, Flanagan, Sarah E, Babiker, Tarig, Thomas, Nicholas J, Shepherd, Maggie H, Ellard, Sian, Klimes, Iwar, Szopa, Magdalena, Polak, Michel, Iafusco, Dario, Hattersley, Andrew T, and Njølstad, Pål R

Published
2018
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39. The treatment of obesity in children and adolescents: consensus position statement of the Italian society of pediatric endocrinology and diabetology, Italian Society of Pediatrics and Italian Society of Pediatric Surgery

Author

Maffeis, Claudio, primary, Olivieri, Francesca, additional, Valerio, Giuliana, additional, Verduci, Elvira, additional, Licenziati, Maria Rosaria, additional, Calcaterra, Valeria, additional, Pelizzo, Gloria, additional, Salerno, Mariacarolina, additional, Staiano, Annamaria, additional, Bernasconi, Sergio, additional, Buganza, Raffaele, additional, Crinò, Antonino, additional, Corciulo, Nicola, additional, Corica, Domenico, additional, Destro, Francesca, additional, Di Bonito, Procolo, additional, Di Pietro, Mario, additional, Di Sessa, Anna, additional, deSanctis, Luisa, additional, Faienza, Maria Felicia, additional, Filannino, Grazia, additional, Fintini, Danilo, additional, Fornari, Elena, additional, Franceschi, Roberto, additional, Franco, Francesca, additional, Franzese, Adriana, additional, Giusti, Lia Franca, additional, Grugni, Graziano, additional, Iafusco, Dario, additional, Iughetti, Lorenzo, additional, Lera, Riccardo, additional, Limauro, Raffaele, additional, Maguolo, Alice, additional, Mancioppi, Valentina, additional, Manco, Melania, additional, Del Giudice, Emanuele Miraglia, additional, Morandi, Anita, additional, Moro, Beatrice, additional, Mozzillo, Enza, additional, Rabbone, Ivana, additional, Peverelli, Paola, additional, Predieri, Barbara, additional, Purromuto, Salvo, additional, Stagi, Stefano, additional, Street, Maria Elisabeth, additional, Tanas, Rita, additional, Tornese, Gianluca, additional, Umano, Giuseppina Rosaria, additional, and Wasniewska, Malgorzata, additional

Published
2023
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42. Implementing Control‐IQ technology after a virtual educational camp in children and adolescents with type 1 diabetes: Does time in range plateau over 1 year?

Author

Scaramuzza, Andrea E., Marigliano, Marco, Bonfanti, Riccardo, Cherubini, Valentino, Schiaffini, Riccardo, Toni, Sonia, Rabbone, Ivana, Abate Daga, Federico, Bassi, Marta, Berioli, Maria Giulia, Bruzzi, Patrizia, Calandretti, Michela, Carducci, Chiara, Cavalli, Claudio, Delvecchio, Maurizio, Gesuita, Rosaria, Giorda, Sara, Iafusco, Dario, Lenzi, Lorenzo, and Lombardo, Fortunato

Subjects
TYPE 1 diabetes, INSULIN pumps, CAMPS for children, TEENAGERS, DIABETES in children, CLOSED loop systems
Published
2024
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43. Nasal glucagon is safe and effective in children and adolescents with type 1 diabetes: A real‐world prospective cohort study.

Author

Zucchini, Stefano, Ripoli, Carlo, Cherubini, Valentino, Coccioli, Maria Susanna, Delvecchio, Maurizio, De Marco, Rosaria, Franceschi, Roberto, Gallo, Francesco, Graziani, Vanna, Iafusco, Dario, Innaurato, Stefania, Lasagni, Anna, Lombardo, Fortunato, Marigliano, Marco, Monti, Sara, Pascarella, Filomena, Pezzino, Giulia, Predieri, Barbara, Rabbone, Ivana, and Schiaffini, Riccardo

Subjects
TYPE 1 diabetes, GLUCAGON, DIABETES in children, COHORT analysis, PEOPLE with diabetes
Published
2024
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45. Glycemia Risk Index as a novel metric to evaluate the safety of glycemic control in children and adolescents with Type 1 Diabetes: an observational, multicenter, real-life cohort study.

Author

Piona, Claudia, primary, Marigliano, Marco, additional, Roncarà, Chiara, additional, Mozzillo, Enza, additional, Di Candia, Francesca, additional, Zanfardino, Angela, additional, Iafusco, Dario, additional, Maltoni, Giulio, additional, Zucchini, Stefano, additional, Piccinno, Elvira, additional, Delvecchio, Maurizio, additional, Passanisi, Stefano, additional, Lombardo, Fortunato, additional, Bonfanti, Riccardo, additional, and Maffeis, Claudio, additional

Published
2023
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46. From Metabolic Syndrome to Type 2 Diabetes in Youth

Author

Iafusco, Dario, primary, Franceschi, Roberto, additional, Maguolo, Alice, additional, Guercio Nuzio, Salvatore, additional, Crinò, Antonino, additional, Delvecchio, Maurizio, additional, Iughetti, Lorenzo, additional, Maffeis, Claudio, additional, Calcaterra, Valeria, additional, and Manco, Melania, additional

Published
2023
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48. Prevalence and Multidimensional Model of Disordered Eating in Youths With Type 1 Diabetes: Results From a Nationwide Population-Based Study.

Author

Troncone, Alda, Affuso, Gaetana, Cascella, Crescenzo, Chianese, Antonietta, Zanfardino, Angela, Iafusco, Dario, and Diabetology, Diabetes Study Group of Italian Society of Paediatric Endocrinology and

Subjects
TYPE 1 diabetes, GLYCOSYLATED hemoglobin, DIABETES in children, STRUCTURAL equation modeling, FOOD habits, CHILD patients
Abstract

Objective The aim of this study was to report nationwide data of the prevalence of disordered eating behaviors (DEBs) in adolescents with type 1 diabetes (T1D) and to evaluate a multidimensional model of eating problems, analyzing how psychopathological problems are associated with DEBs and with metabolic control. Methods This study was carried out using a cross-sectional design with a sample of 1,562 patients with T1D (812 male), aged 11–19 years. Participants were recruited from multiple pediatric diabetes centers (N  =   30) located in northern, central, and southern Italy, and they individually completed the Diabetes Eating Problem Survey–Revised (DEPS-r) and the Youth Self-Report (YSR). Sociodemographic and clinical data were also gathered. Multiple-group structural equation modeling was used to investigate the relationships between internalizing/externalizing symptoms, DEBs, and glycosylated hemoglobin (HbA1c) values. Results A total of 29.7% of the participants reported DEBs (DEPS-r scores ≥20), 42.4% reported insulin manipulation (IM). The prevalence of DEBs was higher for female participants (p ≤.001). The model explains 37% of the variance in disordered eating, 12% in IM, and 21% in HbA1c values. Body mass index, externalizing symptoms, and internalizing symptoms were significantly and positively associated with DEBs, which in turn were significantly and positively associated with HbA1c values (all p ≤.001). Externalizing (p ≤.001) and internalizing (p ≤.01) symptoms were also directly associated with HbA1c values. Conclusion Given the relevant prevalence of DEBs, their significant positive association with psychopathological symptoms, and their relationship with worse diabetes outcomes, regular psychological screening and support is needed to ensure the best care of adolescents with T1D. [ABSTRACT FROM AUTHOR]

Published
2023
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50. COVID-19 forced restrictions did not affect metabolic control in youth with T2D in Italy

Author

Zucchini, Stefano, primary, Iafusco, Dario, additional, Cherubini, Valentino, additional, De Sanctis, Luisa, additional, Maltoni, Giulio, additional, Lenzi, Lorenzo, additional, Mozzillo, Enza, additional, Calcaterra, Valeria, additional, Gallo, Francesco, additional, Arnaldi, Claudia, additional, Delvecchio, Maurizio, additional, Rabbone, Ivana, additional, Minuto, Nicola, additional, Predieri, Barbara, additional, Zanfardino, Angela, additional, Piscopo, Alessia, additional, Tiberi, Valentina, additional, Tinti, Davide, additional, Rapini, Novella, additional, Toni, Sonia, additional, and Schiaffini, Riccardo, additional

Published
2023
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