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1. Fatal Oropouche Virus Infections in Nonendemic Region, Brazil, 2024. (DISPATCHES)

Author

Bandeira, Antonio Carlos, Pereira, Felicidade Mota, Leal, Arabela, Santos, Sara P.O., Barbosa, Ana Claudia, Souza, Marcia Sao Pedro Leal, Souza, Daniele Ribeiro de, Guimaraes, Natalia, Fonseca, Vagner, Giovanetti, Marta, Alcantara, Luiz Carlos, Junior, Lessa, Andre Alvarez A., Saavedra, Ramon Costa, Tome, Luiz Marcelo R., Iani, Felipe Campos M., Barros, Rivia Mary, Purificacao, Sandra Maria O., de Jesus, Jaciara Prado, Fonseca, Ricardo Rosario, and Araujo, Marcio Luis Valenca

Subjects
Diagnosis, Development and progression, Research, Patient outcomes, Arbovirus diseases -- Development and progression -- Patient outcomes -- Diagnosis, Epidemiology -- Research
Abstract

Oropouche virus (OROV), the etiologic agent of Oropouche fever, is an arbovirus that belongs to the Orthobunyavirus genus of the Peribunyaviridae family (1). Discovered in 1955 in Trinidad and Tobago, [...]

Published
2024
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4. Loxosceles amazonica Brown Spider venom: Insights into enzymatic activities, immunorecognition, and novel phospholipase D isoforms

Author

Silva-Magalhães, Rafaela, Silva-Araújo, Ana Luiza, Peres-Damásio, Pamella, Teixeira Pereira, Elaine Henriques, de Oliveira Souza, Ramon, Varela, Luana Silveira da Rocha Nowicki, Tomé, Luiz Marcelo Ribeiro, de Melo Iani, Felipe Campos, Silveira, Adriano Lima, Borges, Márcia Helena, Medina-Santos, Raíssa, Chavez-Olórtegui, Carlos, Vasconcelos Diniz, Marcelo Ribeiro, Paiva, Ana Luiza Bittencourt, and Guerra-Duarte, Clara

Published
2024
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5. Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay

Author

Morel, Noelia, Giovanetti, Marta, Fonseca, Vagner, Burgueño, Analía, Lima, Mauricio, Castro, Emerson, Guimarães, Natália R., Iani, Felipe C.M., Bormida, Victoria, Cortinas, Maria Noel, Ramas, Viviana, Coppola, Leticia, Bento, Ana I., Rosewell, Alexander, Franco, Leticia, Mendez Rico, Jairo, Lourenço, José, Junior Alcantara, Luiz Carlos, and Chiparelli, Hector

Published
2024
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6. Rapid Epidemic Expansion of Chikungunya Virus East/Central/ South African Lineage, Paraguay

Author

Giovanetti, Marta, Vazquez, Cynthia, Lima, Mauricio, Castro, Emerson, Rojas, Analia, de la Fuente, Andrea Gomez, Aquino, Carolina, Cantero, Cesar, Fleitas, Fatima, Torales, Juan, Barrios, Julio, Ortega, Maria J., Gamarra, Maria L., Villalba, Shirley, Alfonzo, Tania, Xavier, Joilson, Adelino, Talita, Fritsch, Hegger, Iani, Felipe C.M., Pereira, Glauco C., de Oliveira, Carla, Schuab, Gabriel, Rodrigues, Evandra S., Kashima, Simone, Leite, Juliana, Gresh, Lionel, Franco, Leticia, Tegally, Houriiyah, Van Voorhis, Wesley C., Lessels, Richard, de Filippis, Ana Maria Bispo, Ojeda, Andrea, Sequera, Guillermo, Montoya, Romeo, Holmes, Edward C., de Oliveira, Tulio, Rico, Jairo M., Lourenco, Jose, Fonseca, Vagner, and Alcantara, Luiz C.J.

Subjects
Pan American Health Organization -- Services, Control, Identification and classification, Prevention, Risk factors, Services, Chikungunya virus -- Identification and classification -- Control, Neonatal diseases -- Risk factors -- Prevention, Infants (Newborn) -- Diseases
Abstract

Chikungunya is a mosquitoborne disease caused by the chikungunya virus (CHIKV), a single-stranded positive-sense RNA virus belonging to the family Togaviridae (1), which is transmitted to humans through the bite [...]

Published
2023
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7. Genomic Surveillance of Monkeypox Virus, Minas Gerais, Brazil, 2022

Author

Guimaraes, Natalia R., Tome, Luiz Marcelo R., Lamounier, Ludmila O., Silva, Marcos Virncius F., Lima, Mauricio T., da Costa, Alana Vitor B., Luiz, Kelly Cristina M., de Jesus, Ronaldo, de S. Trindade, Giliane, Oliveira, Danilo B., da Fonseca, Flavio G., Fernandes, Ana Paula S.M., de Oliveira, Jaqueline S., Moura, Josiane B.P., Kroon, Erna G., Giovanetti, Marta, Fonseca, Vagner, Alcantara, Luiz, Adelino, Talita Emile R., and Iani, Felipe C. de Melo

Subjects
Minas Gerais, Brazil -- Health aspects, Statistics, Usage, Risk factors, Methods, Health aspects, Disease transmission -- Statistics -- Risk factors, Epidemics -- Statistics -- Risk factors -- Brazil, Sentinel surveillance -- Methods, DNA sequencing -- Usage, Mpox -- Statistics -- Risk factors, Human monkeypox -- Statistics -- Risk factors, Nucleotide sequencing -- Usage, Sentinel health events -- Methods
Abstract

Human mpox (formerly monkeypox) is an emerging zoonotic disease caused by monkeypox virus (MPXV) (1,2). Since the 1970s, mpox outbreaks in humans have occurred sporadically, mainly in Africa (3). In [...]

Published
2023

8. Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil

Author

Xavier, Joilson, Alcantara, Luiz Carlos Junior, Fonseca, Vagner, Lima, Mauricio, Castro, Emerson, Fritsch, Hegger, Oliveira, Carla, Guimarães, Natalia, Adelino, Talita, Evaristo, Mariane, Rodrigues, Evandra S., Santos, Elaine Vieira, de La-Roque, Debora, de Moraes, Laise, Tosta, Stephane, Neto, Adelino, Rosewell, Alexander, Mendonça, Ana Flavia, Leite, Anderson, Vasconcelos, Andreza, Silva de Mello, Arabela L., Vasconcelos, Bergson, Montalbano, Camila A., Zanluca, Camila, Freitas, Carla, de Albuquerque, Carlos F. C., Duarte dos Santos, Claudia Nunes, Santos, Cleiton S., dos Santos, Cliomar Alves, Gonçalves, Crhistinne C. Maymone, Teixeira, Dalane, Neto, Daniel F. L., Cabral, Diego, de Oliveira, Elaine C., Noia Maciel, Ethel L., Pereira, Felicidade Mota, Iani, Felipe, de Carvalho, Fernanda P., Andrade, Gabriela, Bezerra, Gabriela, de Castro Lichs, Gislene G., Pereira, Glauco Carvalho, Barroso, Haline, Franz, Helena Cristina Ferreira, Ferreira, Hivylla, Gomes, Iago, Riediger, Irina N., Rodrigues, Isabela, de Siqueira, Isadora C., Silva, Jacilane, Rico, Jairo Mendez, Lima, Jaqueline, Abrantes, Jayra, do Nascimento, Jean Phellipe M., Wasserheit, Judith N., Pastor, Julia, de Magalhães, Jurandy J. F., Luz, Kleber Giovanni, Lima Neto, Lidio G., Frutuoso, Livia C. V., da Silva, Luana Barbosa, Sena, Ludmila, de Sousa, Luis Arthur F., Pereira, Luiz Augusto, Demarchi, Luiz, Câmara, Magaly C. B., Astete, Marcela G., Almiron, Maria, Lima, Maricelia, Umaki Zardin, Marina C. S., Presibella, Mayra M., Falcão, Melissa B., Gale, Jr., Michael, Freire, Naishe, Marques, Nelson, de Moura, Noely F. O., Almeida Da Silva, Pedro E., Rabinowitz, Peter, da Cunha, Rivaldo V., Trinta, Karen S., do Carmo Said, Rodrigo F., Kato, Rodrigo, Stabeli, Rodrigo, de Jesus, Ronaldo, Hans Santos, Roselene, Kashima, Simone, Slavov, Svetoslav N., Andrade, Tamires, Rocha, Themis, Carneiro, Thiago, Nardy, Vanessa, da Silva, Vinicius, Carvalho, Walterlene G., Van Voorhis, Wesley C., Araujo, Wildo N., de Filippis, Ana M. B., and Giovanetti, Marta

Published
2023
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9. SARS-CoV-2 Spillback to Wild Coatis in Sylvatic-Urban Hotspot, Brazil

Author

Stoffella-Dutra, Ana Gabriella, de Campos, Bruna Hermine, de Silva, Pedro Henrique Bastos, Dias, Karolina Lopes, Domingos, Iago Jose da Silva, Hemetrio, Nadja Simbera, Xavier, Joilson, Iani, Felipe, Fonseca, Vagner, Giovanetti, Marta, de Oliveira, Leonardo Camilo, Teixeira, Mauro Martins, Lobato, Zelia Ines Portela, Ferreira, Helena Lage, Arns, Clarice Weis, Durigon, Edison, Drumond, Betania Paiva, de Carvalho, Luiz Carlos Junior Alcantara Marcelo Pires Nogueira, and de Souza Trindade, Giliane

Subjects
Diseases, Risk factors, Health aspects, Disease transmission -- Risk factors, Metropolitan areas -- Health aspects, Epidemics -- Risk factors -- Brazil, Coatis -- Diseases, COVID-19 -- Risk factors
Abstract

By November 2022, the COVID-19 pandemic had resulted in >630 million cases of disease worldwide (1). During the outbreak, natural occurrence of SARS-CoV-2 infections in animals was a hallmark; infections [...]

Published
2023
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10. Potential use of high-resolution melting analyses for SARS-CoV-2 genomic surveillance

Author

de Souza Andrade, Adriana, Freitas, Eduarda Fernandes, de Castro Barbosa, Emerson, Guimarães, Natália Rocha, de Melo Iani, Felipe Campos, da Costa, Alana Vitor Barbosa, Bernardes, André Felipe Leal, Adelino, Talita Emile Ribeiro, Ataide, Ana Caroline Zampiroli, Gregianini, Tatiana Schäffer, Nunes, Jônathas Dias, Stringari, Lorenzzo Lyrio, Riediger, Irina Nastassja, Fernandes, Sandra Bianchini, de Jesus, Ronaldo, Fonseca, Vagner, and Caldas, Sérgio

Published
2023
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11. Genomic epidemiology of the SARS-CoV-2 epidemic in Brazil

Author

Giovanetti, Marta, Slavov, Svetoslav Nanev, Fonseca, Vagner, Wilkinson, Eduan, Tegally, Houriiyah, Patané, José Salvatore Leister, Viala, Vincent Louis, San, Emmanuel James, Rodrigues, Evandra Strazza, Santos, Elaine Vieira, Aburjaile, Flavia, Xavier, Joilson, Fritsch, Hegger, Adelino, Talita Emile Ribeiro, Pereira, Felicidade, Leal, Arabela, Iani, Felipe Campos de Melo, de Carvalho Pereira, Glauco, Vazquez, Cynthia, Sanabria, Gladys Mercedes Estigarribia, Oliveira, Elaine Cristina de, Demarchi, Luiz, Croda, Julio, dos Santos Bezerra, Rafael, Paola Oliveira de Lima, Loyze, Martins, Antonio Jorge, Renata dos Santos Barros, Claudia, Marqueze, Elaine Cristina, de Souza Todao Bernardino, Jardelina, Moretti, Debora Botequio, Brassaloti, Ricardo Augusto, de Lello Rocha Campos Cassano, Raquel, Mariani, Pilar Drummond Sampaio Corrêa, Kitajima, João Paulo, Santos, Bibiana, Proto-Siqueira, Rodrigo, Cantarelli, Vlademir Vicente, Tosta, Stephane, Nardy, Vanessa Brandão, Reboredo de Oliveira da Silva, Luciana, Gómez, Marcela Kelly Astete, Lima, Jaqueline Gomes, Ribeiro, Adriana Aparecida, Guimarães, Natália Rocha, Watanabe, Luiz Takao, Barbosa Da Silva, Luana, da Silva Ferreira, Raquel, da Penha, Mara Patricia F., Ortega, María José, de la Fuente, Andrea Gómez, Villalba, Shirley, Torales, Juan, Gamarra, María Liz, Aquino, Carolina, Figueredo, Gloria Patricia Martínez, Fava, Wellington Santos, Motta-Castro, Ana Rita C., Venturini, James, do Vale Leone de Oliveira, Sandra Maria, Gonçalves, Crhistinne Cavalheiro Maymone, do Carmo Debur Rossa, Maria, Becker, Guilherme Nardi, Giacomini, Mayra Presibella, Marques, Nelson Quallio, Riediger, Irina Nastassja, Raboni, Sonia, Mattoso, Gabriela, Cataneo, Allan D., Zanluca, Camila, Duarte dos Santos, Claudia N., Assato, Patricia Akemi, Allan da Silva da Costa, Felipe, Poleti, Mirele Daiana, Lesbon, Jessika Cristina Chagas, Mattos, Elisangela Chicaroni, Banho, Cecilia Artico, Sacchetto, Lívia, Moraes, Marília Mazzi, Grotto, Rejane Maria Tommasini, Souza-Neto, Jayme A., Nogueira, Maurício Lacerda, Fukumasu, Heidge, Coutinho, Luiz Lehmann, Calado, Rodrigo Tocantins, Neto, Raul Machado, Bispo de Filippis, Ana Maria, Venancio da Cunha, Rivaldo, Freitas, Carla, Peterka, Cassio Roberto Leonel, de Fátima Rangel Fernandes, Cássia, Navegantes, Wildo, do Carmo Said, Rodrigo Fabiano, Campelo de A e Melo, Carlos F., Almiron, Maria, Lourenço, José, de Oliveira, Tulio, Holmes, Edward C., Haddad, Ricardo, Sampaio, Sandra Coccuzzo, Elias, Maria Carolina, Kashima, Simone, Junior de Alcantara, Luiz Carlos, and Covas, Dimas Tadeu

Published
2022
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13. Geographic Distribution of Vaccinia Virus, Diagnosis and Demographic Aspects of Affected Populations, Minas Gerais, Brazil, 2000–2023.

Author

e Silva, Pedro H. B., de Oliveira, Maycon D., de Almeida, Iara M., Domingos, Iago J. S., Stoffella-Dutra, Ana G., Barbosa Costa, Galileu, de Oliveira, Jaqueline S., Iani, Felipe C. M., de Castro, Márcio R., Abrahão, Jonatas S., Kroon, Erna G., and Trindade, Giliane de S.

Subjects
VACCINIA, POXVIRUS diseases, PUBLIC health surveillance, OCCUPATIONAL diseases, DISEASE outbreaks
Abstract

Since its first report in Brazil in 1999, outbreaks of exanthematous diseases caused by vaccinia virus (VACV) have been a recurring concern, particularly impacting rural regions. Minas Gerais (MG) State, Brazil, has emerged as the epicenter of bovine vaccinia (BV) outbreaks. This study presents a comprehensive overview of VACV circulation in MG State over the past two decades, examining the occurrence and distribution of poxvirus cases and outbreaks and the demographic characteristics of affected populations. Analysis of secondary databases from 2000 to 2023 revealed VACV circulation in at least 149 municipalities, particularly expanding in dairy regions. The study underscores BV as an occupational disease, predominantly affecting rural men involved in dairy cattle activities. Laboratory findings indicate high levels of anti-OPXV antibodies in most individuals, with some showing acute infections confirmed by qPCR testing. This analysis informs public health policies, emphasizing the need for enhanced surveillance of and preventive measures for dairy farming communities. [ABSTRACT FROM AUTHOR]

Published
2025
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14. Epidemiology and evolution of Zika virus in Minas Gerais, Southeast Brazil

Author

Iani, Felipe C.M., Giovanetti, Marta, Fonseca, Vagner, Souza, William M., Adelino, Talita E.R., Xavier, Joilson, Jesus, Jaqueline G., Pereira, Maira A., Silva, Marcos V.F., Costa, Alana V.B., Silva, Erniria C., Mendes, Márcia C.O., Filippis, Ana M.B., Albuquerque, Carlos F.C., Abreu, André L., Oliveira, Marluce A.A., Alcantara, Luiz C.J., and Faria, Nuno R.

Published
2021
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15. Genomic and eco-epidemiological investigations in Uruguay reveal local Chikungunya virus transmission dynamics during its expansion across the Americas in 2023.

Author

Burgueño, Analía, Giovanetti, Marta, Fonseca, Vagner, Morel, Noelia, Lima, Mauricio, Castro, Emerson, Guimarães, Natália R., Iani, Felipe C. M., Bormida, Victoria, Cortinas, Maria Noel, Ramas, Viviana, Coppola, Leticia, Bento, Ana I., Franco, Leticia, Mendez Rico, Jairo, Lourenço, José, Alcantara, Luiz Carlos Junior, and Chiparelli, Hector

Published
2024
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16. Phylogeny-aware linear B-cell epitope predictor detects targets associated with immune response to orthopoxviruses.

Author

Campelo, Felipe, Oliveira, Ana Laura Grossi de, Reis-Cunha, João, Fraga, Vanessa Gomes, Bastos, Pedro Henrique, Ashford, Jodie, Ekárt, Anikó, Adelino, Talita Emile Ribeiro, Silva, Marcos Vinicius Ferreira, Iani, Felipe Campos de Melo, Jesus, Augusto César Parreiras de, Bartholomeu, Daniella Castanheira, Trindade, Giliane de Souza, Fujiwara, Ricardo Toshio, Bueno, Lilian Lacerda, and Lobo, Francisco Pereira

Subjects
MONKEYPOX, VACCINIA, MACHINE learning, ORTHOPOXVIRUSES, SERODIAGNOSIS, B cells
Abstract

We introduce a phylogeny-aware framework for predicting linear B-cell epitope (LBCE)-containing regions within proteins. Our approach leverages evolutionary information by using a taxonomic scaffold to build models trained on hierarchically structured data. The resulting models present performance equivalent or superior to generalist methods, despite using simpler features and a fraction of the data volume required by current state-of-the-art predictors. This allows the utilization of available data for major pathogen lineages to facilitate the prediction of LBCEs for emerging infectious agents. We demonstrate the efficacy of our approach by predicting new LBCEs in the monkeypox (MPXV) and vaccinia viruses. Experimental validation of selected targets using sera from infected patients confirms the presence of LBCEs, including candidates for the differential serodiagnosis of recent MPXV infections. These results point to the use of phylogeny-aware predictors as a useful strategy to facilitate the targeted development of immunodiagnostic tools. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Fatal Oropouche Virus Infections in Nonendemic Region, Brazil, 2024.

Author

Carlos Bandeira, Antonio, Mota Pereira, Felicidade, Leal, Arabela, P. O. Santos, Sara, Claudia Barbosa, Ana, Leal Souza, Marcia Sao Pedro, Ribeiro de Souza, Daniele, Guimaraes, Natalia, Fonseca, Vagner, Giovanetti, Marta, Junior Alcantara, Luiz Carlos, A. Lessa, André Alvarez, Costa Saavedra, Ramon, R. Tomé, Luiz Marcelo, M. Iani, Felipe Campos, Mary Barros, Rivia, O. Purificação, Sandra Maria, Prado de Jesus, Jaciara, Rosário Fonseca, Ricardo, and Valença Araújo, Marcio Luis

Subjects
VIRUS diseases, NEGLECTED diseases, BASIC needs, EPIDEMIOLOGY, PARACOCCIDIOIDOMYCOSIS
Abstract

We report acute Oropouche virus infections in 2 previously healthy women from a nonendemic region of Brazil outside the Amazon Basin. Infections rapidly progressed to hemorrhagic manifestations and fatal outcomes in 4-5 days. These cases highlight the critical need for enhanced surveillance to clarify epidemiology of this neglected disease. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Exploring Dengue Infection in a Vaccinated Individual: Preliminary Molecular Diagnosis and Sequencing Insights.

Author

Adelino, Talita Émile Ribeiro, Pedroso, Sílvia Helena Sousa Pietra, Lima, Maurício, Tomé, Luiz Marcelo Ribeiro, Guimarães, Natália Rocha, Fonseca, Vagner, Silva, Paulo Eduardo de Souza da, Moreno, Keldenn Melo Farias, Silva, Ana Cândida Araújo e, Pinheiro, Náthale Rodrigues, Souza, Carolina Senra Alves de, Alcantara, Luiz Carlos Junior, Giovanetti, Marta, and Iani, Felipe Campos de Melo

Subjects
PUBLIC health surveillance, NUCLEOTIDE sequencing, MOLECULAR diagnosis, VACCINATION, BASIC needs, DENGUE
Abstract

This study examines a case involving a 7-year-old child who developed dengue symptoms following Qdenga vaccination. Despite initial negative diagnostic results, molecular analysis confirmed an infection with DENV4. Next-generation sequencing detected viral RNA from both DENV2 and DENV4 serotypes, which were identified as vaccine-derived strains using specific primers. Phylogenetic analysis further confirmed that these sequences belonged to the Qdenga vaccine rather than circulating wild-type viruses. This case underscores the critical need for precise diagnostic interpretation in vaccinated individuals to avoid misdiagnosis and to strengthen public health surveillance. A comprehensive understanding of vaccine-induced viremia is essential for refining dengue surveillance, improving diagnostic accuracy, and informing public health strategies in endemic regions. [ABSTRACT FROM AUTHOR]

Published
2024
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19. High Frequencies of kdr Mutation and Chikungunya Infection in Aedes aegypti Population from Minas Gerais, Brazil

Author

Almeida-Souza, Pedro Augusto, primary, Oliveira, Cirilo Henrique de, additional, Brito, Luiz Paulo, additional, Teixeira, Thaynara de Jesus, additional, Celestino, Iago Alves, additional, Penha, Gabriele Barbosa, additional, dos Santos, Ronaldo Medeiros, additional, Mendes, Wexley Miranda, additional, Ribeiro, Bergmann Morais, additional, Campos, Fabrício Souza, additional, Roehe, Paulo Michel, additional, Guimarães, Natalia Rocha, additional, Iani, Felipe C. M., additional, Martins, Ademir Jesus, additional, and Abreu, Filipe Vieira Santos de, additional

Published
2024
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20. Detection of Mpox Virus Using a Wastewater Surveillance Approach in Brazil

Author

Calabria de Araujo, Juliana, primary, Carvalho, Ana Paula A., additional, Leal, Cintia D., additional, Natividade, Manuelle, additional, Borin, Marcus, additional, Guerra, Augusto, additional, Carobin, Natalia, additional, Sabino, Adriano, additional, Almada, Mariana, additional, Costa, Maria Cristina M., additional, Saia, Flavia, additional, Frutuoso, Livia V., additional, Iani, Felipe Campos M., additional, Ribeiro, Talita E.A., additional, Fonseca, Vagner, additional, Giovanetti, Marta, additional, and Alcantara, Luiz Carlos Junior, additional

Published
2024
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21. Instagram Helped to Reveal That Aedes aegypti (Diptera: Culicidae) Was the Main Vector of Chikungunya Virus (ECSA-Genotype) and Presented High Frequencies of kdr Mutations during an Explosive Outbreak in Minas Gerais, Brazil, 2023

Author

Almeida-Souza, Pedro Augusto, primary, Oliveira, Cirilo H. de, additional, Brito, Luiz Paulo, additional, Teixeira, Thaynara de Jesus, additional, Celestino, Iago Alves, additional, Figueiredo, Ithallo A., additional, Franca, Aline de Oliveira, additional, Penha, Gabriele Barbosa, additional, Chaves, Danielle C. C., additional, Dos Santos, Ronaldo Medeiros, additional, Mendes, Wexley Miranda, additional, Oliveira, Cláudio Barbosa, additional, Ribeiro, Bergmann Morais, additional, Campos, Fabrício Souza, additional, Roehe, Paulo Michel, additional, Guimaraes, Natalia Rocha, additional, Iani, Felipe C. M., additional, Martins, Ademir, additional, and Abreu, Filipe Vieira Santos de, additional

Published
2024
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22. Metagenomic Analysis for Diagnosis of Hemorrhagic Fever in Minas Gerais, Brazil

Author

Iani, Felipe Campos de Melo, primary, de Campos, Gabriel Montenegro, additional, Adelino, Talita Emile Ribeiro, additional, da Silva, Anielly Sarana, additional, Kashima, Simone, additional, Alcantara, Luiz Carlos Junior, additional, Sampaio, Sandra Coccuzzo, additional, Giovanetti, Marta, additional, Elias, Maria Carolina, additional, and Slavov, Svetoslav Nanev, additional

Published
2024
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23. Genomic and Epidemiological Surveillance of Zika Virus in the Amazon Region

Author

Giovanetti, Marta, Faria, Nuno Rodrigues, Lourenço, José, Goes de Jesus, Jaqueline, Xavier, Joilson, Claro, Ingra Morales, Kraemer, Moritz U.G., Fonseca, Vagner, Dellicour, Simon, Thézé, Julien, da Silva Salles, Flavia, Gräf, Tiago, Silveira, Paola Paz, do Nascimento, Valdinete Alves, Costa de Souza, Victor, de Melo Iani, Felipe Campos, Castilho-Martins, Emerson Augusto, Cruz, Laura Nogueira, Wallau, Gabriel, Fabri, Allison, Levy, Flávia, Quick, Joshua, de Azevedo, Vasco, Aguiar, Renato Santana, de Oliveira, Tulio, Bôtto de Menezes, Camila, da Costa Castilho, Marcia, Terra, Tirza Matos, Souza da Silva, Marineide, Bispo de Filippis, Ana Maria, Luiz de Abreu, André, Oliveira, Wanderson Kleber, Croda, Julio, Campelo de Albuquerque, Carlos F., Nunes, Marcio R.T., Sabino, Ester Cerdeira, Loman, Nicholas, Naveca, Felipe Gomes, Pybus, Oliver G., and Alcantara, Luiz Carlos

Published
2020
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24. Exploring the Genomic Dynamics of the Monkeypox Epidemic in Paraguay

Author

Vazquez, Cynthia, primary, Fonseca, Vagner, additional, de la Fuente, Andrea Gomez, additional, Gonzalez, Sandra, additional, Fleitas, Fatima, additional, Lima, Mauricio, additional, Guimarães, Natália R., additional, Iani, Felipe C. M., additional, Rojas, Analia, additional, Alfonso, Tania, additional, Cantero, Cesar, additional, Barrios, Julio, additional, Villalba, Shirley, additional, Ortega, Maria Jose, additional, Torales, Juan, additional, Gamarra, Maria Liz, additional, Aquino, Carolina, additional, Franco, Leticia, additional, Rico, Jairo Mendez, additional, Alcantara, Luiz Carlos Junior, additional, and Giovanetti, Marta, additional

Published
2024
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25. Genomic characterization of SARS-CoV-2 from an indigenous reserve in Mato Grosso do Sul, Brazil.

Author

Albuquerque de Oliveira, Laís, Mauricio de Rezende, Izabela, João Navarini, Vinicius, Beutinger Marchioro, Silvana, Leite Torres, Alex José, Croda, Julio, Garcia Croda, Mariana, Maymone Gonçalves, Crhistinne Cavalheiro, Xavier, Joilson, de Castro, Emerson, Lima, Mauricio, Iani, Felipe, Adelino, Talita, Aburjaile, Flávia, Ferraz Demarchi, Luiz Henrique, Ledesma Taira, Deborah, Souza Umaki Zardin, Marina Castilhos, Fonseca, Vagner, Giovanetti, Marta, and Andrews, Jason

Published
2024
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26. Detection of Multiple Human Viruses, including Mpox, Using a Wastewater Surveillance Approach in Brazil.

Author

Calabria de Araujo, Juliana, Carvalho, Ana Paula Assad, Leal, Cintia D., Natividade, Manuelle, Borin, Marcus, Guerra, Augusto, Carobin, Natália, Sabino, Adriano, Almada, Mariana, Costa, Maria Cristina M., Saia, Flavia, Frutuoso, Livia V., Iani, Felipe C. M., Adelino, Talita, Fonseca, Vagner, Giovanetti, Marta, and Alcantara, Luiz Carlos Junior

Subjects
WHOLE genome sequencing, SEWAGE disposal plants, PUBLIC health surveillance, MONKEYPOX, SEWAGE
Abstract

Sewage surveillance can be used as an effective complementary tool for detecting pathogens in local communities, providing insights into emerging threats and aiding in the monitoring of outbreaks. In this study using qPCR and whole genomic sewage surveillance, we detected the Mpox virus along with other viruses, in municipal and hospital wastewaters in Belo Horizonte, Brazil over a 9-month period (from July 2022 until March 2023). MPXV DNA detection rates varied in our study, with 19.6% (11 out of 56 samples) detected through the hybrid capture method of whole-genome sequencing and 20% (12 out of 60 samples) through qPCR. In hospital wastewaters, the detection rate was higher, at 40% (12 out of 30 samples) compared to 13.3% (4 out of 30 samples) in municipal wastewaters. This variation could be attributed to the relatively low number of MPXV cases reported in the city, which ranged from 106 to 341 cases during the study period, and the dilution effects, given that each of the two wastewater treatment plants (WWTP) investigated serves approximately 1.1 million inhabitants. Additionally, nine other virus families were identified in both hospitals and municipal wastewaters, including Adenoviridade, Astroviridae, Caliciviridae, Picornaviridade, Polyomaviridae, Coronaviridae (which includes SARS-CoV-2), Herspesviridae, Papillomaviridae and Flaviviridae (notably including Dengue). These findings underscore the potential of genomic sewage surveillance as a robust public health tool for monitoring a wide range of viruses circulating in both community and hospitals environments, including MPXV. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Exploring Microorganisms Associated to Acute Febrile Illness and Severe Neurological Disorders of Unknown Origin: A Nanopore Metagenomics Approach.

Author

Moreno, Keldenn Melo Farias, de Andrade, Virgínia Antunes, de Melo Iani, Felipe Campos, Fonseca, Vagner, Lima, Maurício Teixeira, de Castro Barbosa, Emerson, Tomé, Luiz Marcelo Ribeiro, Guimarães, Natália Rocha, Fritsch, Hegger Machado, Adelino, Talita, Oliveira Fereguetti, Tatiana, Aspahan, Maíra Cardoso, Gamarano Barros, Tereza, Alcantara, Luiz Carlos Junior, and Giovanetti, Marta

Subjects
GENOMICS, HIV, NEUROLOGICAL disorders, ACUTE diseases, METAGENOMICS
Abstract

Acute febrile illness (AFI) and severe neurological disorders (SNDs) often present diagnostic challenges due to their potential origins from a wide range of infectious agents. Nanopore metagenomics is emerging as a powerful tool for identifying the microorganisms potentially responsible for these undiagnosed clinical cases. In this study, we aim to shed light on the etiological agents underlying AFI and SND cases that conventional diagnostic methods have not been able to fully elucidate. Our approach involved analyzing samples from fourteen hospitalized patients using a comprehensive nanopore metagenomic approach. This process included RNA extraction and enrichment using the SMART-9N protocol, followed by nanopore sequencing. Subsequent steps involved quality control, host DNA/cDNA removal, de novo genome assembly, and taxonomic classification. Our findings in AFI cases revealed a spectrum of disease-associated microbes, including Escherichia coli, Streptococcus sp., Human Immunodeficiency Virus 1 (Subtype B), and Human Pegivirus. Similarly, SND cases revealed the presence of pathogens such as Escherichia coli, Clostridium sp., and Dengue virus type 2 (Genotype-II lineage). This study employed a metagenomic analysis method, demonstrating its efficiency and adaptability in pathogen identification. Our investigation successfully identified pathogens likely associated with AFI and SNDs, underscoring the feasibility of retrieving near-complete genomes from RNA viruses. These findings offer promising prospects for advancing our understanding and control of infectious diseases, by facilitating detailed genomic analysis which is critical for developing targeted interventions and therapeutic strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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28. A Multiplex Nanopore Sequencing Approach for the Detection of Multiple Arboviral Species

Author

Xavier, Joilson, primary, Fonseca, Vagner, additional, Adelino, Talita, additional, Iani, Felipe C. M., additional, Pereira, Glauco C., additional, Duarte, Myrian M., additional, Lima, Mauricio, additional, Castro, Emerson, additional, Oliveira, Carla, additional, Fritsch, Hegger, additional, Guimarães, Natalia, additional, Lamounier, Ludmila O., additional, Barreto, Fernanda Khouri, additional, Braga de Oliveira, Camilo M. M., additional, Maymone Gonçalves, Crhistinne C., additional, Malta Lima, Danielle, additional, de Oliveira, Elaine C., additional, de Castro Lichs, Gislene G., additional, Gomes, Iago, additional, Mazaro, Janaina, additional, Rodrigues, Janete T. N., additional, Abrantes, Jayra, additional, Colares, Jeová K. B., additional, Luz, Kleber G., additional, Barbosa da Silva, Luana, additional, Demarchi, Luiz, additional, Câmara, Magaly C. B., additional, Umaki Zardin, Marina C. S., additional, Sabatini Mello Pinheiro, Rafaela, additional, Barbosa Souza, Rutilene, additional, Haddad, Simone K., additional, Figueiredo da Silva, Stephanni, additional, Slavov, Svetoslav N., additional, Rocha, Themis, additional, Morel, Noelia, additional, Chiparelli, Hector, additional, Burgueño, Analía, additional, Bórmida, Victoria, additional, Cortinas, María N., additional, Martín, Rosario S., additional, Pereira, Allan C., additional, dos Santos, Marcelo F., additional, André Júnior, Walter, additional, Mendez Rico, Jairo, additional, Franco, Leticia, additional, Rosewell, Alexander, additional, do Carmo Said, Rodrigo F., additional, de Albuquerque, Carlos F. C., additional, Noia Maciel, Ethel L., additional, Santini de Oliveira, Marília, additional, Venâncio da Cunha, Rivaldo, additional, Vinhal Frutuoso, Livia C., additional, de Filippis, Ana M. B., additional, Giovanetti, Marta, additional, and Carlos Junior Alcantara, Luiz, additional

Published
2023
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29. Genomic characterization of SARS-CoV-2 from an indigenous reserve in Mato Grosso do Sul, Brazil

Author

de Oliveira, Laís Albuquerque, primary, de Rezende, Izabela Mauricio, additional, Navarini, Vinicius João, additional, Marchioro, Silvana Beutinger, additional, Torres, Alex José Leite, additional, Croda, Julio, additional, Croda, Mariana Garcia, additional, Gonçalves, Crhistinne Cavalheiro Maymone, additional, Xavier, Joilson, additional, de Castro, Emerson, additional, Lima, Mauricio, additional, Iani, Felipe, additional, Adelino, Talita, additional, Aburjaile, Flávia, additional, Ferraz Demarchi, Luiz Henrique, additional, Taira, Deborah Ledesma, additional, Zardin, Marina Castilhos Souza Umaki, additional, Fonseca, Vagner, additional, Giovanetti, Marta, additional, Andrews, Jason, additional, Alcantara, Luiz Carlos Junior, additional, and Simionatto, Simone, additional

Published
2023
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30. Pan-genomics of virus and its applications

Author

Giovanetti, Marta, primary, Salgado, Alvaro, additional, de Souza Fonseca, Vagner, additional, Tosta, Fraga de Oliveira, additional, Xavier, Joilson, additional, de Jesus, Jaqueline Goes, additional, Iani, Felipe Campos Melo, additional, Adelino, Talita Emile Ribeiro, additional, Barreto, Fernanda Khouri, additional, Faria, Nuno Rodrigues, additional, de Oliveira, Tulio, additional, and Alcantara, Luiz Carlos Junior, additional

Published
2020
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31. Contributors

Author

Adelino, Talita Emile Ribeiro, primary, Ahmad, Jamil, additional, Ahmed, Shahbaz, additional, Alcantara, Luiz Carlos Junior, additional, Ali, Amjad, additional, Amir, Rabia, additional, Araujo, Fabricio, additional, Arveen, Muneeba, additional, Azevedo, Vasco, additional, Azhar, Jahanzaib, additional, Balbo, Luciana, additional, Bao, Li, additional, Barh, Debmalya, additional, Barreto, Fernanda Khouri, additional, Bhatti, Attya, additional, Burkovski, Andreas, additional, Chideroli, Roberta Torres, additional, Corredor, Mauricio, additional, da Costa Pinheiro, Kenny, additional, da Costa Silva, Artur Luiz, additional, Dar, Hamza Arshad, additional, de Castro Oliveira, Letícia, additional, de Castro Soares, Siomar, additional, de Jesus, Jaqueline Goes, additional, de Jesus Sousa, Thiago, additional, de Oliveira, Tulio, additional, de Oliveira Tosta, Stephane Fraga, additional, de Pádua Pereira, Ulisses, additional, de Souza Fonseca, Vagner, additional, Dhawan, Dipali, additional, Facimoto, César Toshio, additional, Faria, Nuno Rodrigues, additional, Fatima, Nosheen, additional, Figueiredo, Henrique César Pereira, additional, Giovanetti, Marta, additional, Góes-Neto, Aristóteles, additional, Gomide, Anne Cybelle Pinto, additional, Guimarães, Luis Carlos, additional, Hurtado, Raquel Enma, additional, Iani, Felipe Campos Melo, additional, Ibraim, Izabela Coimbra, additional, Imchen, Madangchanok, additional, Jaiswal, Arun Kumar, additional, Jamal, Syed Babar, additional, John, Peter, additional, Kato, Rodrigo Bentes, additional, Kaur, Jaspreet, additional, Kaur, Bineypreet, additional, Kumavath, Ranjith, additional, Liu, Xiaofeng, additional, Luan, Nguyen Thanh, additional, Maqsood, Wajahat, additional, da Silva, Wanderson Marques, additional, Minhas, Anupriya, additional, Munir, Faiza, additional, Muñoz-Gómez, Amalia, additional, Naz, Kanwal, additional, Naz, Anam, additional, Obaid, Ayesha, additional, Pantoja, Yan, additional, Ramos, Rommel, additional, Saba, Noor Ul, additional, Salgado, Alvaro, additional, Sangal, Vartul, additional, Sani, Qurat-ul-Ain, additional, Seyffert, Nubia, additional, Sheraz Shah, Faisal, additional, Shahid, Fatima, additional, Shehroz, Muhammad, additional, Siddiqa, Amnah, additional, Srivastava, Gyan P., additional, Tavares, Guilherme Campos, additional, Thi, Hai Ha Pham, additional, Tiwari, Sandeep, additional, Tiwary, Basant K., additional, Ullah, Nimat, additional, Vennapu, Ravali Krishna, additional, Xavier, Joilson, additional, Yadav, Neelam, additional, Yadav, Bhupendra N.S., additional, Yadav, Rajiv K., additional, Yadav, Dinesh K., additional, and Zaheer, Tahreem, additional

Published
2020
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32. Epidemiological and genomic investigation of chikungunya virus in Rio de Janeiro state, Brazil, between 2015 and 2018

Author

Moreira, Filipe Romero Rebello, primary, Menezes, Mariane Talon de, additional, Salgado-Benvindo, Clarisse, additional, Whittaker, Charles, additional, Cox, Victoria, additional, Chandradeva, Nilani, additional, Paula, Hury Hellen Souza de, additional, Martins, André Frederico, additional, Chagas, Raphael Rangel das, additional, Brasil, Rodrigo Decembrino Vargas, additional, Cândido, Darlan da Silva, additional, Herlinger, Alice Laschuk, additional, Ribeiro, Marisa de Oliveira, additional, Arruda, Monica Barcellos, additional, Alvarez, Patricia, additional, Tôrres, Marcelo Calado de Paula, additional, Dorigatti, Ilaria, additional, Brady, Oliver, additional, Voloch, Carolina Moreira, additional, Tanuri, Amilcar, additional, Iani, Felipe, additional, Souza, William Marciel de, additional, Cardozo, Sergian Vianna, additional, Faria, Nuno Rodrigues, additional, and Aguiar, Renato Santana, additional

Published
2023
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33. Genomics-based timely detection of Dengue Virus type I genotypes I and V in Uruguay

Author

Morel, Noelia, primary, Giovanetti, Marta, additional, Fonseca, Vagner, additional, Burgueño, Analía, additional, Lima, Mauricio, additional, Castro, Emerson, additional, R. Guimarães, Natália, additional, Iani, Felipe C. M., additional, Bormida, Victoria, additional, Cortinas, Maria Noel, additional, Ramas, Viviana, additional, Coppola, Leticia, additional, Bento, Ana I., additional, Rosewell, Alexander, additional, Franco, Leticia, additional, Rico, Jairo Mendez, additional, Lourenço, José, additional, Alcantara, Luiz Carlos Junior, additional, and Chiparelli, Hector, additional

Published
2023
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34. Genomic epidemiology unveils the dynamics and spatial corridor behind the Yellow Fever virus outbreak in Southern Brazil

Author

Giovanetti, Marta, primary, Pinotti, Francesco, additional, Zanluca, Camila, additional, Fonseca, Vagner, additional, Nakase, Taishi, additional, Koishi, Andrea C., additional, Tscha, Marcel, additional, Soares, Guilherme, additional, Dorl, Gisiane Gruber, additional, Marques, Antônio Ernesto M.L, additional, Sousa, Renato, additional, Adelino, Talita Emile Ribeiro, additional, Xavier, Joilson, additional, de Oliveira, Carla, additional, Patroca, Sandro, additional, Guimaraes, Natalia Rocha, additional, Fritsch, Hegger, additional, Mares-Guia, Maria Angélica, additional, Levy, Flavia, additional, Passos, Pedro Henrique, additional, da Silva, Vinicius Leme, additional, Pereira, Luiz Augusto, additional, Mendonça, Ana Flávia, additional, de Macêdo, Isabel Luana, additional, Ribeiro de Sousa, Davi Emanuel, additional, Rodrigues de Toledo Costa, Gabriela, additional, Botelho de Castro, Marcio, additional, de Souza Andrade, Miguel, additional, de Abreu, Filipe Vieira Santos, additional, Campos, Fabrício Souza, additional, Iani, Felipe Campos de Melo, additional, Pereira, Maira Alves, additional, Cavalcante, Karina Ribeiro Leite Jardim, additional, de Freitas, Andre Ricardo Ribas, additional, Campelo de Albuquerque, Carlos Frederico, additional, Macário, Eduardo Marques, additional, dos Anjos, Marlei Pickler Debiasi, additional, Ramos, Rosane Campanher, additional, Campos, Aline Alves Scarpellini, additional, Pinter, Adriano, additional, Chame, Marcia, additional, Abdalla, Livia, additional, Riediger, Irina Nastassja, additional, Ribeiro, Sérvio Pontes, additional, Bento, Ana I., additional, de Oliveira, Tulio, additional, Freitas, Carla, additional, Oliveira de Moura, Noely Fabiana, additional, Fabri, Allison, additional, dos Santos Rodrigues, Cintia Damasceno, additional, Dos Santos, Carolina Cardoso, additional, Barreto de Almeida, Marco Antonio, additional, dos Santos, Edmilson, additional, Cardoso, Jader, additional, Augusto, Douglas Adriano, additional, Krempser, Eduardo, additional, Mucci, Luís Filipe, additional, Gatti, Renata Rispoli, additional, Cardoso, Sabrina Fernandes, additional, Fuck, João Augusto Brancher, additional, Lopes, Maria Goretti David, additional, Belmonte, Ivana Lucia, additional, Mayoral Pedroso da Silva, Gabriela, additional, Soares, Maiane Regina Ferreira, additional, de Castilhos, Marilia de Melo Santos, additional, de Souza e Silva, Joseana Cardoso, additional, Bisetto Junior, Alceu, additional, Pouzato, Emanuelle Gemin, additional, Tanabe, Laurina Setsuko, additional, Arita, Daniele Akemi, additional, Matsuo, Ricardo, additional, dos Santos Raymundo, Josiane, additional, Silva, Paula Cristina Linder, additional, Santana Araújo Ferreira Silva, Ana, additional, Samila, Sandra, additional, Carvalho, Glauco, additional, Stabeli, Rodrigo, additional, Navegantes, Wildo, additional, Moreira, Luciano Andrade, additional, Ferreira, Alvaro Gil A., additional, Pinheiro, Guilherme Garcia, additional, Nunes, Bruno Tardelli Diniz, additional, de Almeida Medeiros, Daniele Barbosa, additional, Cruz, Ana Cecília Ribeiro, additional, Venâncio da Cunha, Rivaldo, additional, Van Voorhis, Wes, additional, Bispo de Filippis, Ana Maria, additional, Almiron, Maria, additional, Holmes, Edward C., additional, Ramos, Daniel Garkauskas, additional, Romano, Alessandro, additional, Lourenço, José, additional, Alcantara, Luiz Carlos Junior, additional, and Duarte dos Santos, Claudia Nunes, additional

Published
2023
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35. Rapid Epidemic Expansion of Chikungunya Virus East/Central/South African Lineage, Paraguay

Author

Giovanetti, Marta, primary, Vazquez, Cynthia, additional, Lima, Mauricio, additional, Castro, Emerson, additional, Rojas, Analia, additional, Gomez de la Fuente, Andrea, additional, Aquino, Carolina, additional, Cantero, Cesar, additional, Fleitas, Fatima, additional, Torales, Juan, additional, Barrios, Julio, additional, Ortega, Maria J., additional, Gamarra, Maria L., additional, Villalba, Shirley, additional, Alfonzo, Tania, additional, Xavier, Joilson, additional, Adelino, Talita, additional, Fritsch, Hegger, additional, Iani, Felipe C.M., additional, Pereira, Glauco C., additional, de Oliveira, Carla, additional, Schuab, Gabriel, additional, Rodrigues, Evandra S., additional, Kashima, Simone, additional, Leite, Juliana, additional, Gresh, Lionel, additional, Franco, Leticia, additional, Tegally, Houriiyah, additional, Van Voorhis, Wesley C., additional, Lessels, Richard, additional, de Filippis, Ana Maria Bispo, additional, Ojeda, Andrea, additional, Sequera, Guillermo, additional, Montoya, Romeo, additional, Holmes, Edward C., additional, de Oliveira, Tulio, additional, Rico, Jairo M., additional, Lourenço, José, additional, Fonseca, Vagner, additional, and Alcantara, Luiz C.J., additional

Published
2023
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36. Genomic and eco-epidemiological investigations in Uruguay reveal local Chikungunya virus transmission dynamics during its expansion across the Americas in 2023.

Author

Burgueno, Analia, primary, Giovanetti, Marta, additional, Fonseca, Vagner, additional, Morel, Maria Noelia, additional, Lima, Mauricio, additional, Castro, Emerson, additional, Guimaraes, Natalia R., additional, Iani, Felipe C. M., additional, Bormida, Victoria, additional, Cortinas, Maria Noel, additional, Ramas, Viviana, additional, Coppola, Leticia, additional, Bento, Ana I., additional, Franco, Leticia, additional, Mendez Rico, Jairo, additional, Lourenco, Jose, additional, Alcantara, Luiz Carlos Junior, additional, and Chiparelli, Hector, additional

Published
2023
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37. Resurgence of Dengue Virus Serotype 3 in Minas Gerais, Brazil: A Case Report.

Author

Adelino, Talita, Lima, Maurício, Guimarães, Natália R., Xavier, Joilson, Fonseca, Vagner, Tomé, Luiz Marcelo R., Pereira, Maira Alves, Machado, Vanessa Ferreira, Alcantara, Luiz Carlos Junior, Iani, Felipe C. de Melo, and Giovanetti, Marta

Subjects
DENGUE, DENGUE viruses, MOSQUITO-borne diseases, MOSQUITO control
Abstract

This report provides a detailed overview of the resurgence of DENV-3 in the state of Minas Gerais, Brazil, which is a concerning scenario in the context of dengue, a mosquito-borne viral disease. Historically, Brazil has grappled with dengue epidemics caused primarily by the DENV-1 and DENV-2 serotypes. However, in 2023, a significant shift in this pattern was observed as DENV-3 made a notable resurgence. This resurgence was characterized by the increase in DENV-3 cases within the country and the region of the Americas. Given the absence of sustained DENV-3 circulation in Brazil in previous years, this situation poses a significant risk, making the population highly susceptible to a potential novel epidemic. In November 2023, a 31-year-old male patient in Belo Horizonte exhibited symptoms of acute febrile syndrome. Multiplex RT-qPCR using the Kit Molecular ZC D-Tipagem confirmed DENV-3 infection, suggesting a likely autochthonous case, as the patient reported no travel history. To promptly assess this resurgence, we applied the nanopore sequencing technology. This allowed for the rapid characterization of the initial DENV-3 case isolated in Minas Gerais in 2023, representing a 13-year interval since the serotype's previous documented circulation in that state. This case report underscores the critical importance of proactive monitoring and the swift implementation of targeted control strategies to address the evolving dynamics of dengue, with a specific emphasis on the resurgence of DENV-3 in the state. [ABSTRACT FROM AUTHOR]

Published
2024
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38. A Multiplex Nanopore Sequencing Approach for the Detection of Multiple Arboviral Species.

Author

Xavier, Joilson, Fonseca, Vagner, Adelino, Talita, Iani, Felipe C. M., Pereira, Glauco C., Duarte, Myrian M., Lima, Mauricio, Castro, Emerson, Oliveira, Carla, Fritsch, Hegger, Guimarães, Natalia, Lamounier, Ludmila O., Barreto, Fernanda Khouri, Braga de Oliveira, Camilo M. M., Maymone Gonçalves, Crhistinne C., Malta Lima, Danielle, de Oliveira, Elaine C., de Castro Lichs, Gislene G., Gomes, Iago, and Mazaro, Janaina

Subjects
ARBOVIRUSES, REVERSE transcriptase polymerase chain reaction, CHIKUNGUNYA virus, YELLOW fever, POLYMERASE chain reaction
Abstract

The emergence and continued geographic expansion of arboviruses and the growing number of infected people have highlighted the need to develop and improve multiplex methods for rapid and specific detection of pathogens. Sequencing technologies are promising tools that can help in the laboratory diagnosis of conditions that share common symptoms, such as pathologies caused by emerging arboviruses. In this study, we integrated nanopore sequencing and the advantages of reverse transcription polymerase chain reaction (RT-PCR) to develop a multiplex RT-PCR protocol for the detection of Chikungunya virus (CHIKV) and several orthoflaviviruses (such as dengue (Orthoflavivirus dengue), Zika (Orthoflavivirus zikaense), yellow fever (Orthoflavivirus flavi), and West Nile (Orthoflavivirus nilense) viruses) in a single reaction, which provides data for sequence-based differentiation of arbovirus lineages. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Retrospective Spatio-Temporal Dynamics of Dengue Virus 1, 2 and 4 in Paraguay

Author

Vazquez, Cynthia, primary, Alcantara, Luiz Carlos Junior, additional, Fonseca, Vagner, additional, Lima, Mauricio, additional, Xavier, Joilson, additional, Adelino, Talita, additional, Fritsch, Hegger, additional, Castro, Emerson, additional, de Oliveira, Carla, additional, Schuab, Gabriel, additional, Lima, Alex Ranieri Jerônimo, additional, Villalba, Shirley, additional, Gomez de la Fuente, Andrea, additional, Rojas, Analia, additional, Cantero, Cesar, additional, Fleitas, Fatima, additional, Aquino, Carolina, additional, Ojeda, Andrea, additional, Sequera, Guillermo, additional, Torales, Juan, additional, Barrios, Julio, additional, Elias, Maria Carolina, additional, Iani, Felipe C. M., additional, Ortega, Maria Jose, additional, Gamarra, Maria Liz, additional, Montoya, Romeo, additional, Rodrigues, Evandra Strazza, additional, Kashima, Simone, additional, Sampaio, Sandra Coccuzzo, additional, Coluchi, Norma, additional, Leite, Juliana, additional, Gresh, Lionel, additional, Franco, Leticia, additional, Lourenço, José, additional, Rico, Jairo Mendez, additional, Bispo de Filippis, Ana Maria, additional, and Giovanetti, Marta, additional

Published
2023
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40. Rapid epidemic expansion of chikungunya virus-ECSA lineage in Paraguay

Author

Giovanetti, Marta, primary, Vazquez, Cynthia, additional, Lima, Mauricio, additional, Castro, Emerson, additional, Rojas, Analia, additional, de la Fuente, Andrea Gomez, additional, Aquino, Carolina, additional, Cantero, Cesar, additional, Fleitas, Fatima, additional, Torales, Juan, additional, Barrios, Julio, additional, Ortega, Maria Jose, additional, Gamarra, Maria Liz, additional, Villalba, Shirley, additional, Alfonzo, Tania, additional, Xavier, Joilson, additional, Adelino, Talita, additional, Fritsch, Hegger, additional, Iani, Felipe C. M., additional, Pereira, Glauco Carvalho, additional, de Oliveira, Carla, additional, Schuab, Gabriel, additional, Rodrigues, Evandra Strazza, additional, Kashima, Simone, additional, Leite, Juliana, additional, Gresh, Lionel, additional, Franco, Leticia, additional, Tegally, Houriiyah, additional, Van Voorhis, Wesley C., additional, Lessels, Richard, additional, de Filippis, Ana Maria Bispo, additional, Ojeda, Andrea, additional, Sequera, Guillermo, additional, Montoya, Romeo, additional, Holmes, Edward C., additional, de Oliveira, Tulio, additional, Rico, Jairo Mendez, additional, Lourenço, José, additional, Fonseca, Vagner, additional, and Junior Alcantara, Luiz Carlos, additional

Published
2023
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41. Increased interregional virus exchange and nucleotide diversity outline the expansion of the chikungunya virus ECSA lineage in Brazil

Author

Xavier, Joilson, primary, Alcantara, Luiz, additional, Fonseca, Vagner, additional, Lima, Mauricio, additional, Castro, Emerson, additional, Fritsch, Hegger, additional, Oliveira, Carla, additional, Guimarães, Natalia, additional, Adelino, Talita, additional, Evaristo, Mariane, additional, Rodrigues, Evandra S., additional, Santos, Elaine Vieira, additional, de La-Roque, Debora, additional, de Moraes, Laise, additional, Tosta, Stephane, additional, Neto, Adelino, additional, Rosewell, Alexander, additional, Mendonça, Ana Flavia, additional, Leite, Anderson, additional, Vasconcelos, Andreza, additional, Silva de Mello, Arabela L., additional, Vasconcelos, Bergson, additional, Montalbano, Camila A., additional, Zanluca, Camila, additional, Freitas, Carla, additional, de Albuquerque, Carlos F. C., additional, Duarte dos Santos, Claudia Nunes, additional, Santos, Cleiton S., additional, Alves dos Santos, Cliomar, additional, Maymone Gonçalves, Crhistinne C., additional, Teixeira, Dalane, additional, Neto, Daniel F. L., additional, Cabral, Diego, additional, de Oliveira, Elaine C., additional, Noia Maciel, Ethel L., additional, Pereira, Felicidade Mota, additional, Iani, Felipe, additional, de Carvalho, Fernanda P., additional, Andrade, Gabriela, additional, Bezerra, Gabriela, additional, de Castro Lichs, Gislene G., additional, Pereira, Glauco Carvalho, additional, Barroso, Haline, additional, Ferreira Franz, Helena Cristina, additional, Ferreira, Hivylla, additional, Gomes, Iago, additional, Riediger, Irina N., additional, Rodrigues, Isabela, additional, de Siqueira, Isadora C., additional, Silva, Jacilane, additional, Rico, Jairo Mendez, additional, Lima, Jaqueline, additional, Abrantes, Jayra, additional, do Nascimento, Jean Phellipe M., additional, Wasserheit, Judith N., additional, Pastor, Julia, additional, de Magalhães, Jurandy J. F., additional, Luz, Kleber Giovanni, additional, Lima Neto, Lidio G., additional, Frutuoso, Livia C. V., additional, da Silva, Luana Barbosa, additional, Sena, Ludmila, additional, de Sousa, Luis Arthur F., additional, Pereira, Luiz Augusto, additional, Demarchi, Luiz, additional, Câmara, Magaly C. B., additional, Astete, Marcela G., additional, Almiron, Maria, additional, Lima, Maricelia, additional, Umaki Zardin, Marina C. S., additional, Presibella, Mayra M., additional, Falcão, Melissa B., additional, Gale, Michael, additional, Freire, Naishe, additional, Marques, Nelson, additional, de Moura, Noely F. O., additional, Almeida Da Silva, Pedro E., additional, Rabinowitz, Peter, additional, da Cunha, Rivaldo V., additional, Trinta, Karen S., additional, do Carmo Said, Rodrigo F., additional, Kato, Rodrigo, additional, Stabeli, Rodrigo, additional, de Jesus, Ronaldo, additional, Santos, Roselene Hans, additional, Haddad, Simone K., additional, Slavov, Svetoslav N., additional, Andrade, Tamires, additional, Rocha, Themis, additional, Carneiro, Thiago, additional, Nardy, Vanessa, additional, da Silva, Vinicius, additional, Carvalho, Walterlene G., additional, Van Voorhis, Wesley C., additional, Araujo, Wildo N., additional, de Filippis, Ana M.B., additional, and Giovanetti, Marta, additional

Published
2023
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42. Ultrastructural analysis of monkeypox virus replication in Vero cells

Author

Witt, Amanda Stéphanie Arantes, primary, Trindade, Giliane de Souza, additional, Souza, Fernanda Gil de, additional, Serafim, Mateus Sá Magalhães, additional, da Costa, Alana Vitor Barbosa, additional, Silva, Marcos Vinícius Ferreira, additional, de Melo Iani, Felipe Campos, additional, Rodrigues, Rodrigo Araújo Lima, additional, Kroon, Erna Geessien, additional, and Abrahão, Jônatas Santos, additional

Published
2023
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43. Genomic epidemiology sheds light on the recent spatio-temporal dynamics of Yellow Fever virus and the spatial corridor that fueled its ongoing emergence in southern Brazil

Author

Giovanetti, Marta, primary, Pinotti, Francesco, additional, Zanluca, Camila, additional, Fonseca, Vagner, additional, Nakase, Taishi, additional, Koishi, Andrea C., additional, Tscha, Marcel, additional, Soares, Guilherme, additional, Dorl, Gisiane Gruber, additional, Marques, Antônio Ernesto M.L, additional, Sousa, Renato, additional, Ribeiro Adelino, Talita Emile, additional, Xavier, Joilson, additional, de Oliveira, Carla, additional, da Silva, Sandro Patroca, additional, Guimaraes, Natalia Rocha, additional, Fritsch, Hegger, additional, Angélica Mares-Guia, Maria, additional, Levy, Flavia, additional, Passos, Pedro Henrique, additional, da Silva, Vinicius Leme, additional, Pereira, Luiz Augusto, additional, Mendonça, Ana Flávia, additional, de Macêdo, Isabel Luana, additional, de Sousa, Davi Emanuel Ribeiro, additional, de Toledo Costa, Gabriela Rodrigues, additional, de Castro, Marcio Botelho, additional, de Melo Iani, Felipe Campos, additional, Pereira, Maira Alves, additional, Jardim Cavalcante, Karina Ribeiro Leite, additional, de Freitas, Andre Ricardo Ribas, additional, de Albuquerque, Carlos Frederico Campelo, additional, Macário, Eduardo Marques, additional, dos Anjos, Marlei Pickler Debiasi, additional, Ramos, Rosane Campanher, additional, Scarpellini Campos, Aline Alves, additional, Pinter, Adriano, additional, Chame, Marcia, additional, Abdalla, Livia, additional, Riediger, Irina Nastassja, additional, Ribeiro, Sérvio Pontes, additional, Bento, Ana Isabel, additional, de Oliveira, Tulio, additional, Freitas, Carla, additional, de Moura, Noely Fabiana Oliveira, additional, Fabri, Allison, additional, Santos Rodrigues, Cintia Damasceno Dos, additional, Dos Santos, Carolina Cardoso, additional, de Almeida, Marco Antonio Barreto, additional, Santos, Edmilson dos, additional, Cardoso, Jader, additional, Augusto, Douglas Adriano, additional, Krempser, Eduardo, additional, Mucci, Luís Filipe, additional, Gatti, Renata Rispoli, additional, Cardoso, Sabrina Fernandes, additional, Brancher Fuck, João Augusto, additional, David Lopes, Maria Goretti, additional, Belmonte, Ivana Lucia, additional, da Silva, Gabriela Mayoral Pedroso, additional, Ferreira Soares, Maiane Regina, additional, de Melo Santos de Castilhos, Marilia, additional, de Souza e Silva, Joseana Cardoso, additional, Junior, Alceu Bisetto, additional, Pouzato, Emanuelle Gemin, additional, Tanabe, Laurina Setsuko, additional, Arita, Daniele Akemi, additional, Matsuo, Ricardo, additional, Santos Raymundo, Josiane dos, additional, Linder Silva, Paula Cristina, additional, Araújo Ferreira Silva, Ana Santana, additional, Samila, Sandra, additional, Carvalho, Glauco, additional, Stabeli, Rodrigo, additional, Navegantes, Wildo, additional, Moreira, Luciano Andrade, additional, A. Ferreira, Alvaro Gil, additional, Pinheiro, Guilherme Garcia, additional, Diniz Nunes, Bruno Tardelli, additional, de Almeida Medeiros, Daniele Barbosa, additional, Ribeiro Cruz, Ana Cecília, additional, da Cunha, Rivaldo Venâncio, additional, Van Voorhis, Wes, additional, de Filippis, Ana Maria Bispo, additional, Almiron, Maria, additional, Holmes, Edward C., additional, Ramos, Daniel Garkauskas, additional, Romano, Alessandro, additional, Lourenço, José, additional, Junior Alcantara, Luiz Carlos, additional, and dos Santos, Claudia Nunes Duarte, additional

Published
2023
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44. Monitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study

Author

Alves, Hugo José, primary, de Araújo, João Locke Ferreira, additional, Fonseca, Paula Luize Camargos, additional, Moreira, Filipe Romero Rebello, additional, Bonfim, Diego Menezes, additional, Queiroz, Daniel Costa, additional, Miguita, Lucyene, additional, de Souza, Rafael Marques, additional, Geddes, Victor Emmanuel Viana, additional, Costa, Walyson Coelho, additional, Oliveira, Jaqueline Silva de, additional, Medeiros, Eva Lídia Arcoverde, additional, Souza, Carolina Senra Alves de, additional, Saliba, Juliana Wilke, additional, Menezes, André Luiz, additional, Oliveira, Eneida Santos de, additional, Adelino, Talita Emile Ribeiro, additional, Guimaraes, Natalia Rocha, additional, Ribeiro, Adriana Aparecida, additional, Moreira, Rennan Garcias, additional, Zauli, Danielle Alves Gomes, additional, Silva, Joice do Prado, additional, Malta, Frederico Scott Varella, additional, Ferreira, Alessandro Clayton de Souza, additional, Silva, Ana Valesca Fernandes Gilson, additional, Alfenas-Zerbini, Poliane, additional, Souza, Flavia Oliveira de, additional, Sabino, Adriano de Paula, additional, Xavier, Laura do Amaral, additional, Carobin, Natália Virtude, additional, Carvalho, Alex Fiorini de, additional, Lourenço, Karine Lima, additional, Teixeira, Santuza Maria Ribeiro, additional, Fernandes, Ana Paula Salles Moura, additional, Fonseca, Flavio Guimarães da, additional, Abrahão, Jônatas Santos, additional, Iani, Felipe Campos de Melo, additional, Rodrigues, Rodrigo Araújo Lima, additional, Souza, Renan Pedra de, additional, and Aguiar, Renato Santana, additional

Published
2022
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45. Retrospective Genomic Surveillance of Chikungunya Transmission in Minas Gerais State, Southeast Brazil

Author

Fritsch, Hegger, primary, Giovanetti, Marta, additional, Xavier, Joilson, additional, Adelino, Talita Emile Ribeiro, additional, Fonseca, Vagner, additional, de Jesus, Jaqueline Góes, additional, de Jesus, Ronaldo, additional, Freitas, Carla, additional, Peterka, Cassio Roberto Leonel, additional, Campelo de Albuquerque, Carlos Frederico, additional, Bispo de Filippis, Ana Maria, additional, da Cunha, Rivaldo Venâncio, additional, Silva, Erniria Carvalhais, additional, Alcantara, Luiz Carlos Junior, additional, and Iani, Felipe Campos de Melo, additional

Published
2022
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46. Low prevalence of influenza A strains with resistance markers in Brazil during 2017–2019 seasons

Author

Sousa, Thiago das Chagas, primary, Martins, Jessica Santa Cruz Carvalho, additional, Miranda, Milene Dias, additional, Garcia, Cristiana Couto, additional, Resende, Paola Cristina, additional, Santos, Cliomar A., additional, Debur, Maria do Carmo, additional, Rodrigues, Rodrigo Ribeiro, additional, Cavalcanti, Andrea Cony, additional, Gregianini, Tatiana Schäffer, additional, Iani, Felipe Campos de Melo, additional, Pereira, Felicidade Mota, additional, Fernandes, Sandra Bianchini, additional, Ferreira, Jessylene de Almeida, additional, Santos, Katia Correa de Oliveira, additional, Motta, Fernando, additional, Brown, David, additional, Almeida, Walquiria Aparecida Ferreira de, additional, Siqueira, Marilda Mendonça, additional, and Matos, Aline da Rocha, additional

Published
2022
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47. Climate and land-use shape the spread of zoonotic yellow fever virus

Author

Hill, Sarah C., primary, Dellicour, Simon, additional, Claro, Ingra M., additional, Sequeira, Patricia C., additional, Adelino, Talita, additional, Thézé, Julien, additional, Wu, Chieh-Hsi, additional, Rebello Moreira, Filipe Romero, additional, Giovanetti, Marta, additional, Li, Sabrina L., additional, de Jesus, Jaqueline G., additional, Colón-González, Felipe J., additional, Chamberlain, Heather R., additional, Pannell, Oliver, additional, Tejedor-Garavito, Natalia, additional, de Bruycker-Nogueira, Fernanda, additional, Fabri, Allison A., additional, Angélica Mares-Guia, Maria, additional, Xavier, Joilson, additional, Zarebski, Alexander E., additional, Hamlet, Arran, additional, Mureb Sallum, Maria Anice, additional, da Costa, Antonio C., additional, Manuli, Erika R., additional, Levin, Anna S., additional, Mucci, Luís Filipe, additional, Tubaki, Rosa Maria, additional, de Menezes, Regiane Maria Tironi, additional, de Deus, Juliana Telles, additional, Spinola, Roberta, additional, Saad, Leila, additional, Kallas, Esper G., additional, Wint, G.R. William, additional, Peixoto, Pedro S., additional, de Souza Santos, Andreza Aruska, additional, Messina, Jane P., additional, Brady, Oliver J., additional, Tatem, Andrew J., additional, Suchard, Marc A., additional, Mendez-Rico, Jairo A., additional, Abreu, André, additional, Aguiar, Renato Santana, additional, Pybus, Oliver G., additional, Baele, Guy, additional, Lemey, Philippe, additional, Iani, Felipe, additional, Cunha, Mariana S., additional, de Filippis, Ana M. Bispo, additional, Sabino, Ester C., additional, and Faria, Nuno R., additional

Published
2022
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48. Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status

Author

Fonseca, Paula L C, primary, Moreira, Filipe R R, additional, de Souza, Rafael M, additional, Guimarães, Natália R, additional, Carvalho, Nara O, additional, Adelino, Talita E R, additional, Alves, Hugo J, additional, Alvim, Luige B, additional, Candido, Darlan S, additional, Coelho, Helena P, additional, Costa, Alana V B, additional, Costa, Walyson C, additional, de Carvalho, Alex F, additional, de Faria, Bruna W F, additional, de Lima, Aline B, additional, de Oliveira, Eneida S, additional, de Souza, Carolina S A, additional, de Souza, Fernanda G, additional, Dias, Rillery C, additional, Geddes, Victor E V, additional, Godinho, Igor P, additional, Gonçalves, Alessandro L, additional, Lourenço, Karine L, additional, Magalhães, Rubens D M, additional, Malta, Frederico S V, additional, Medeiros, Eva L A, additional, Mendes, Fernanda S, additional, Mendes, Pedro H B de P, additional, Mendonça, Cristiane P T B, additional, Menezes, Andre L, additional, Menezes, Diego, additional, Menezes, Mariane T, additional, Miguita, Lucyene, additional, Moreira, Rennan G, additional, Peixoto, Renata B, additional, Queiroz, Daniel C, additional, Ribeiro, Adriana A, additional, Ribeiro, Ana Paula de B, additional, Saliba, Juliana W, additional, Sato, Hugo I, additional, Silva, Joice do P, additional, Silva, Natiely P, additional, Faria, Nuno R, additional, Teixeira, Santuza M R, additional, da Fonseca, Flávio G, additional, Fernandes, Ana Paula S M, additional, Zauli, Danielle A G, additional, Januario, José Nélio, additional, de Oliveira, Jaqueline S, additional, Iani, Felipe C de M, additional, de Aguiar, Renato S, additional, and de Souza, Renan P, additional

Published
2022
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49. Phylogenetic-based inference reveals distinct transmission dynamics of SARS-CoV-2 lineages Gamma and P.2 in Brazil

Author

Gräf, Tiago, primary, Bello, Gonzalo, additional, Naveca, Felipe Gomes, additional, Gomes, Marcelo, additional, Cardoso, Vanessa Leiko Oikawa, additional, da Silva, Alexandre Freitas, additional, Dezordi, Filipe Zimmer, additional, dos Santos, Mirleide Cordeiro, additional, Santos, Katia Correa de Oliveira, additional, Batista, Érika Lopes Rocha, additional, Magalhães, Alessandro Leonardo Álvares, additional, Vinhal, Fernando, additional, Miyajima, Fábio, additional, Faoro, Helisson, additional, Khouri, Ricardo, additional, Wallau, Gabriel Luz, additional, Delatorre, Edson, additional, Siqueira, Marilda Mendonça, additional, Resende, Paola Cristina, additional, Mattos, Tirza Peixoto, additional, Nascimento, Valdinete Alves, additional, Souza, Victor, additional, Corado, André de Lima Guerra, additional, Nascimento, Fernanda, additional, Silva, George, additional, Mejía, Matilde, additional, Brandão, Maria Júlia, additional, Costa, Ágatha, additional, Pessoa, Karina, additional, Jesus, Michele, additional, Gonçalves, Luciana Fé, additional, Fernandes, Cristiano, additional, Andrade, Valnete, additional, Barbagelata, Luana, additional, Cruz, Ana Cecília Ribeiro, additional, Costa, Andrea, additional, Silva, Lindomar dos Anjos, additional, Galvão, Jucimária Dantas, additional, Leite, Anderson Brandao, additional, Pereira, Felicidade Mota, additional, Costa, Thais Oliveira, additional, Sousa, Joaquim Cesar, additional, Neto, Lidio Gonçalves Lima, additional, Barroso, Haline, additional, Teixeira, Dalane Loudal Florentino, additional, Bezerra, Joao Felipe, additional, Docena, Cássia, additional, de Lima, Raul Emídio, additional, Silva, Lilian Caroliny Amorim, additional, de Lima, Gustavo Barbosa, additional, Machado, Laís Ceschini, additional, Bezerra, Matheus Filgueira, additional, Paiva, Marcelo Henrique Santos, additional, Dantas, Maria Eduarda Pessoa Lopes, additional, Pereira, Raíssa Liane Do Nascimento, additional, Araújo, Josélio, additional, Santos, Cliomar A., additional, Ribeiro-Rodrigues, Rodrigo, additional, Bernardes, André Felipe Leal, additional, Iani, Felipe Campos de Melo, additional, Grinsztejn, Beatriz, additional, Veloso, Valdiléa G., additional, Brasil, Patricia, additional, da Paixão, Anna Carolina Dias, additional, Appolinario, Luciana Reis, additional, Lopes, Renata Serrano, additional, Motta, Fernando do Couto, additional, Rocha, Alice Sampaio, additional, Venas, Taina Moreira Martins, additional, Pereira, Elisa Cavalcante, additional, Cavalcanti, Andrea Cony, additional, Bastos, Leonardo Soares, additional, Brigido, Luis Fernando de Macedo, additional, Oliveira, Mauro de Medeiros, additional, Schemberger, Michelle Orane, additional, Suzukawa, Andreia Akemi, additional, Riediger, Irina, additional, Debur, Maria do Carmo, additional, Salvato, Richard Steiner, additional, Gregianini, Tatiana Schäffer, additional, Rovaris, Darcita Buerger, additional, and Fernandes, Sandra Bianchini, additional

Published
2022
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50. Spotted Fever in the Morphoclimatic Domains of Minas Gerais State, Brazil

Author

de Carvalho Nunes, Emília, de Moura-Martiniano, Nicole Oliveira, de Lima Duré, Ana Íris, de Melo Iani, Felipe Campos, de Oliveira, Stefan Vilges, de Mello, Flávio Luis, and Gazêta, Gilberto Salles

Subjects
General Medicine
Abstract

In Brazil, the tick-borne rickettsiosis known as Spotted Fever (SF) has been recorded from 59% of the Federative Units, however, the knowledge of the epidemiology and dynamics of human infection remains incipient in certain areas, complicating appropriate public health actions to inform the general population and control the disease. Here, we improved the interpretation of epidemiological information of SF cases recorded for an important endemic area. A descriptive epidemiological study was carried out based on records in the SINAN (Notifiable Diseases Information System) SF case databases. Data analysis was performed using Python programming language, Pandas library and Qgis map making. To evaluate the sociodemographic, clinical, assistance, laboratory and epidemiological characteristics, simple and relative nominal values of occurrences, means and standard deviations, and molecular analyzes were performed to identify the bioagent present in biological samples collected during each case investigation. Of the 298 confirmed cases, 98 resulted in death, the number of cases increased from 2011, and the disease scenario had 32.8% lethality. Overall, 207 cases involved men, and lethality was higher in this group. The most affected age group was 30 to 59 years old. The majority of patients reported having had contact with animals such as ticks, capybara and domestic animals such as dogs and cats. The results corroborate existing studies in areas of severe SF cases in Brazil. Despite reports of SF cases from the Cerrado Biome, analyses show that serious cases occur in anthropized areas of the Atlantic Forest biome, and in a transition area between this and the Cerrado. Complex, longitudinal, multidisciplinary studies, with an eco-epidemiological focus, should be carried out to allow the construction of algorithms capable of predicting, in time and space, the risk factors associated with severe cases and deaths from SF, with the aim of avoiding their expansion.

Published
2022
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