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487 results on '"Iannazzo, Daniela"'

9. Sterile inflammation induced by respirable micro and nano polystyrene particles in the pathogenesis of pulmonary diseases.

Author

Antonio, Laganà, Visalli, Giuseppa, Facciolà, Alessio, Saija, Caterina, Bertuccio, Maria Paola, Baluce, Barbara, Celesti, Consuelo, Iannazzo, Daniela, and Pietro, Angela Di

Subjects
LUNG diseases, PROTEIN analysis, MICROPLASTICS, CELL lines, POLYSTYRENE
Abstract

Sterile inflammation is involved in the lung pathogenesis induced by respirable particles, including micro- and nanoplastics. Their increasing amounts in the ambient and in indoor air pose a risk to human health. In two human cell lines (A549 and THP-1) we assessed the proinflammatory behavior of polystyrene nanoplastics (nPS) and microplastics (mPS) (Ø 0.1 and 1 μm). Reproducing environmental aging, in addition to virgin, the cells were exposed to oxidized nPS/mPS. To study the response of the monocytes to the inflammatory signal transmitted by the A549 through the release of soluble factors (e.g. alarmins and cytokines), THP-1 cells were also exposed to the supernatants of previously nPS/mPS-treated A549. After dynamic-light-scattering (DLS) analysis and protein measurements for the assessment of protein corona in nPS/mPS, real-time PCR and enzyme-linked-immunosorbent (ELISA) assays were performed in exposed cells. The pro-inflammatory effects of v- and ox-nPS/mPS were attested by the imbalance of the Bax/Bcl-2 ratio in A549, which was able to trigger the inflammatory cascade, inhibiting the immunologically silent apoptosis. The involvement of NFkB was confirmed by the overexpression of p65 after exposure to ox-nPS and v- and ox-mPS. The fast and higher levels of IL-1β, only in THP-1 cells, underlined the NLPR3 inflammasome activation. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Modified Gold Screen-Printed Electrodes for the Determination of Heavy Metals.

Author

Celesti, Consuelo, Giofrè, Salvatore Vincenzo, Espro, Claudia, Legnani, Laura, Neri, Giovanni, and Iannazzo, Daniela

Subjects
GOLD electrodes, HEAVY metals, METAL detectors, METAL ions, SQUARE waves
Abstract

Screen-printed electrodes (SPEs) are reliable, portable, affordable, and versatile electrochemical platforms for the real-time analytical monitoring of emerging analytes in the environmental, clinical, and agricultural fields. The aim of this study was to evaluate the electrochemical behavior of gold screen-printed electrodes (SPGEs) modified with molecules containing amino (Tr-N) or α-aminophosphonate (Tr-P) groups for the selective and sensitive detection of the toxic metal ions Pb2+ and Hg2+ in aqueous samples. After optimizing the analytical parameters (conditioning potential and time, deposition potential and time, pH and concentration of the supporting electrolyte), anodic square wave stripping voltammetry (SWASV) was used to evaluate and compare the electrochemical performance of bare or modified electrodes for the detection of Hg2+ and Pb2+, either alone or in their mixtures in the concentration range between 1 nM and 10 nM. A significative improvement in the detection ability of Pb2+ ions was recorded for the amino-functionalized gold sensor SPGE-N, while the presence of a phosphonate moiety in SPGE-P led to greater sensitivity towards Hg2+ ions. The developed sensors allow the detection of Pb2+ and Hg2+ with a limit of detection (LOD) of 0.41 nM and 35 pM, respectively, below the legal limits for these heavy metal ions in drinking water or food, while the sensitivity was 5.84 µA nM−1cm−2 and 10 µA nM−1cm−2, respectively, for Pb2+ and Hg2+. The reported results are promising for the development of advanced devices for the in situ and cost-effective monitoring of heavy metals, even in trace amounts, in water resources. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Solid Lipid Nanoparticles Containing Morin: Preparation, Characterization, and Ex Vivo Permeation Studies

Author

De Gaetano, Federica, primary, Celesti, Consuelo, additional, Paladini, Giuseppe, additional, Venuti, Valentina, additional, Cristiano, Maria Chiara, additional, Paolino, Donatella, additional, Iannazzo, Daniela, additional, Strano, Vincenza, additional, Gueli, Anna M., additional, Tommasini, Silvana, additional, Ventura, Cinzia Anna, additional, and Stancanelli, Rosanna, additional

Published
2023
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24. Lead ion (Pb2+) electrochemical sensors based on novel Schiff base ligands

Author

Akbari, Zahra, Abid, Khouloud, Iannazzo, Daniela, Montazerozohori, Morteza, Fazio, Enza, Neri, Fortunato, Corsaro, Carmelo, and Neri, Giovanni

Abstract

In this study, a novel bidentate Schiff base ligand, namely (1E,1′E,2E,2′E)-N,N′-(butane-1,4-diyl)bis(3-(2-methoxyphenyl)prop-2-en-1-imine) (L1), and a tetradentate Schiff base ligand, namely N1,N2-bis(2-(((1E,2E)-3-(4-(dimethylamino)phenyl)allylidene)amino)ethyl)ethane-1,2-diamine (L2), were successfully synthesized through a simple procedure. The synthesized Schiff base ligands were characterized by scanning electron microscopy (SEM) analysis, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), nuclear magnetic resonance (NMR) and ultraviolet-visible (UV-vis) spectroscopy. Moreover, the thermal behavior was studied through thermogravimetric (TG)/differential thermogravimetric (DTG)/differential thermal (DT) analyses under a nitrogen atmosphere. Subsequently, the features and performances of the synthesized ligands (L1and L2) as electrochemical sensors for the detection of heavy metal ions (HMIs) have been investigated. A different behavior was noticed using these two ligands, with L1being the best candidate for developing a modified screen-printed carbon electrode (L1/SPCE) electrochemical Pb2+sensor. To improve further the performances, gold nanoparticles (AuNPs) were deposited by an electrochemical process on the L1/SPCE platform. The developed AuNPs-L1/SPCE sensor displayed enhanced lead ion sensing with a high sensitivity of 56.78 μA μM−1cm−2and a detection limit of 0.298 μM. This novel sensor demonstrated promising performances for the detection of Pb2+ions in real seawater with no sample treatment.

Published
2024
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25. List of Contributors

Author

Acharya, Chinmayee, primary, Akhter, Sohail, additional, Avti, Pramod K., additional, Axente, Emanuel, additional, Balas, Mihaela, additional, Baskın, Yasemin, additional, Beg, Sarwar, additional, Bhaskara, Prakash K., additional, Bitas, Dimitrios, additional, Bleotu, Coralia, additional, Chaudhuri, Biswadeep, additional, Chifiriuc, Mariana C., additional, Eskiizmir, Görkem, additional, Fong, Jessica F.Y., additional, Friedrich, Jörg, additional, Galvagno, Signorino, additional, Garka, Shruthi, additional, Grumezescu, Valentina, additional, Hasnain, M.S., additional, Iannazzo, Daniela, additional, Imam, Sarim, additional, Ion, Ioana, additional, Jain, Atul, additional, Kamerzan, Crina, additional, Kazmi, Imran, additional, Khan, Haseeb A., additional, Khan, Isra, additional, Lazăr, Veronica, additional, Lee, Yong-kyu, additional, Magerramova, Matanat, additional, Marimuthu, Mohana, additional, Măruţescu, Luminiţa, additional, Mousavi, Farimah, additional, Nagiyev, Tofik, additional, Negut, Irina, additional, Ng, Sing M., additional, Ng, Yann H., additional, Nica, Ionela C., additional, Oprea, Eliza, additional, Panda, Chitta R., additional, Perepelytsina, Olena M., additional, Pistone, Alessandro, additional, Popa, Marcela, additional, Rahman, Mahfoozur, additional, Ravichandiran, Velayutham, additional, Saini, Sumant, additional, Samanidou, Victoria, additional, Samantara, Aneeya K., additional, Sasmal, Abhisek, additional, Satpathy, Dharmendra, additional, Sima, Livia E., additional, Skariyachan, Sinosh, additional, Stan, Miruna S., additional, Strugari, Alina F.G., additional, Swain, Suryakanta, additional, Sydorenko, Mychailo V., additional, Taherpour, Avat A., additional, Ugnivenko, Andriy P., additional, Veerapandian, Murugan, additional, Yapıcı, Kerim, additional, Zeynalov, Eldar, additional, and Ziccarelli, Ida, additional

Published
2018
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27. Microwave transducers for moisture content characterization of cultural heritage materials

Author

Gugliandolo, Giovanni, primary, Altadonna, Alessio, additional, Arena, Adriana, additional, Arena, Marina, additional, Calabrese, Luigi, additional, Campobello, Giuseppe, additional, Crupi, Giovanni, additional, Iannazzo, Daniela, additional, Passalacqua, Francesca, additional, Todesco, Fabio, additional, Xibilia, Maria Gabriella, additional, and Donato, Nicola, additional

Published
2023
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32. Chitosan/POSS Hybrid Hydrogels for Bone Tissue Engineering

Author

Celesti, Consuelo, primary, Iannazzo, Daniela, additional, Espro, Claudia, additional, Visco, Annamaria, additional, Legnani, Laura, additional, Veltri, Lucia, additional, Visalli, Giuseppa, additional, Di Pietro, Angela, additional, Bottino, Paola, additional, and Chiacchio, Maria Assunta, additional

Published
2022
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33. Orange-Peel-Derived Nanobiochar for Targeted Cancer Therapy

Author

Iannazzo, Daniela, primary, Celesti, Consuelo, additional, Espro, Claudia, additional, Ferlazzo, Angelo, additional, Giofrè, Salvatore V., additional, Scuderi, Mario, additional, Scalese, Silvia, additional, Gabriele, Bartolo, additional, Mancuso, Raffaella, additional, Ziccarelli, Ida, additional, Visalli, Giuseppa, additional, and Di Pietro, Angela, additional

Published
2022
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37. Promising Materials in the Fight against Healthcare-Associated Infections: Antibacterial Properties of Chitosan-Polyhedral Oligomeric Silsesquioxanes Hybrid Hydrogels.

Author

Laganà, Antonio, Facciolà, Alessio, Iannazzo, Daniela, Celesti, Consuelo, Polimeni, Evelina, Biondo, Carmelo, Di Pietro, Angela, and Visalli, Giuseppa

Subjects
RHEOLOGY, DRUG resistance in bacteria, BIOMEDICAL materials, SURFACE charges, CONFOCAL microscopy, GRAM-positive bacteria, SILICONES
Abstract

New technologies and materials could help in this fight against healthcare-associated infections. As the majority of these infections are caused by antibiotic-resistant bacteria, the development of materials with intrinsic antibacterial properties is a promising field of research. We combined chitosan (CS), with antibacterial properties, with polyhedral oligomeric silsesquioxanes (POSS), a biocompatible polymer with physico-chemical, mechanical, and rheological properties, creating a hydrogel using cross-linking agent genipin. The antibacterial properties of CS and CS-POSS hydrogels were investigated against nosocomial Gram-positive and Gram-negative bacteria both in terms of membrane damage and surface charge variations, and finally, the anti-biofilm property was studied through confocal microscopy. Both materials showed a good antibacterial capacity against all analyzed strains, both in suspension, with % decreases between 36.36 and 73.58 for CS and 29.86 and 66.04 for CS-POSS, and in plates with % decreases between 55.29 and 78.32 and 17.00 and 53.99 for CS and CS-POSS, respectively. The treated strains compared to the baseline condition showed an important membrane damage, which also determined a variation of surface charges, and finally, for both hydrogels, a remarkable anti-biofilm property was highlighted. Our findings showed a possible future use of these biocompatible materials in the manufacture of medical and surgical devices with intrinsic antibacterial and anti-biofilm properties. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Recent Advances on the Synthesis of Azepane‐Based Compounds

Author

Faisca Phillips, AMMM, Chiacchio, M, Legnani, L, Chiacchio, U, Iannazzo, D, Chiacchio, Maria Assunta, Legnani, Laura, Chiacchio, Ugo, Iannazzo, Daniela, Faisca Phillips, AMMM, Chiacchio, M, Legnani, L, Chiacchio, U, Iannazzo, D, Chiacchio, Maria Assunta, Legnani, Laura, Chiacchio, Ugo, and Iannazzo, Daniela

Abstract

Azepane–based compounds are saturated seven-membered carbocycles where one carbon atom is replaced with a nitrogen atom. The azepane structure is also found in fused-ring derivatives endowed of a wide range of pharmacological activities. The azepane motif is in the top 100 most frequently used ring systems for small molecule drugs. Several synthetic methods toward the preparation of new azepane-based compounds scaffolds have gained significant interest and represent a continuous challenge for synthetic organic chemists. The synthesis of the azepane ring is based on different synthetic approaches such as: ring-closing reactions; ring-expansion reactions of cyclic compounds; and multistep sequences. The azepane based compounds continue to play great synthetic relevance because of their different biological activities such as anti-cancer, antimicrobial, anti-Alzheimer's disease and anticonvulsant activity. New synthetic methods for the construction of azepane derivatives endowed of relevant biological activity and good pharmacological profiles is expected in near future.

Published
2022

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