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3. Early versus late intubation in COVID-19 patients failing helmet CPAP: A quantitative computed tomography study

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Ball, Lorenzo, Robba, Chiara, Herrmann, Jacob, Gerard, Sarah E., Xin, Yi, Pigati, Maria, Berardino, Andrea, Iannuzzi, Francesca, Battaglini, Denise, Brunetti, Iole, Minetti, Giuseppe, Seitun, Sara, Vena, Antonio, Giacobbe, Daniele Roberto, Bassetti, Matteo, Rocco, Patricia R.M., Cereda, Maurizio, Castellan, Lucio, Patroniti, Nicolò, and Pelosi, Paolo

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2022
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4. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

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Pan, Hongchao, Peto, Richard, Henao Restrepo, Ana Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Karim, Quarraisha Abdool, Alejandria, Marissa, Hernàndez García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K. Srinath, Periago, Mirta Roses, Hanna, Pierre Abi, Abutidze, Akaki, Ader, Florence, Al-Bader, Abdullah, Alhasawi, Almonther, Allum, Emma, Al Mawali, Adhra, Alotaibi, Athari, Alvarez- Moreno, Carlos, Appadoo, Sheila, Arts, Derk, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Genetu Bayih, Abebe, Beaumont, Helena, Bellani, Samir, Benassi, Virginia, Bhargava, Balram, Branca, Mattia, Cappel-Porter, Heike, Cerrato, Nery, Cheick Haidara, Fadima, Chow, Ting Soo, Como, Nadia, Eustace, Joe, Gabunia, Tamar, García, Patricia, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Hassan, Mariam, Hassany, Mohamed, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Khamis, Faryal, Kirwan, Jana, Kumar, Suresh, Lennon, Peter, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Manevska, Suzana, Manuel, Oriol, McGinty, Sybil, Medina, Marco, Mesa Rubio, Maria Lucia, Miranda Montoya, Maria Consuelo, Nel, Jeremy, Nunes, Estevao, Perola, Markus, Portoles, Antonio, Rasmin, Menaldi, Raza, Aun, Rees, Helen, Reges, Paula, Rogers, Chris, Salami, Kolawole, Salvadori, Marina, Sauermann, Mamatha, Sinani, Narvina, Sow, Samba, Sterne, Jonathan AC, Stevanovikj, Milena, Tacconelli, Evelina, Tavares Maltez, Fernando Manuel, Teferi, Mekonnen, Tikkinen, Kari, Trelle, Sven, Tsertsvadze, Tengiz, Zaid, Hala, Røttingen, John-Arne, Swaminathan, Soumya, Ryan, Michael, Gjermeni, Nevila, Meta, Esmeralda, Aguila, Damian, Alonso, Ignacio, Altamirano, Marcos, Alvarez, María, Alzola, Rodrigo, Arce, Veronica, Arribillaga, Patricia, Avila, Rafael, Balbuena, Juan, Barcelona, Laura, Barletta, José, Benedetti, María, Berdiñas, Verónica, Burgui, Julieta, Caimi, Sabrina, Carrillo, Juan, Carrizo, Juan, Castelli, Juan, Cazaux, Alexis, Cervellino, Flavia, Chalco, Angelo, Chediack, Viviana, Cunto, Eleonora, D'Amico, Nicolàs, de Vedia, Lautaro, Delgado, Carolina, Di Pilla, Debora, Díaz, Miguel, Díaz Aguiar, Pablo, Domínguez, Cecilia, Ellero, Leonor, Farina, Javier, Fernàndez, José, Ferreyra, Roxana, Filippi, María, Fogar, Carolina, Frare, Pablo, Giudiche, Celeste, Golikow, Mariana, Gomez, Maria Georgina, Hermida, Laura, Hurtado, Mariano, Jacobo, Mariela, Jaume, Martin, Laplume, Diego, Lescano, María, Lista, Nicolàs, Loiacono, Flavia, López, Ana Belen, Losso, Marcelo, Luna, Cecilia, Lupo, Sergio, Marianelli, Leonardo, Martin, Anabella, Masciottra, Florencia, Mykietiuk, Analía, Orellano, Lorena, Pachioli, Valeria, Padilla, María José, Pallavicini, Cecilia, Patroso, Jazmin, Perez Blanco, Luz, Presas, Jose Louis, Provenzano, Matias, Lavera, Lorena, Reichert, Viviana, Riveros, Florencia, Rodríguez, Alejandra, Rolon, María José, Salvay, Carolina, Simonetta, María, Sisto, Alicia, Themines, Sandra, Tito, Fernando, Toibaro, Javier, Torales, Graciela, Verón, Luciano, Vizzotti, Carla, Egle, Alexander, Greil, Richard, Joannidis, Michael, Altdorfer, Antoine, Belkhir, Leila, Fraipont, Vincent, Hites, Maya, Arruda, Erico, Breda, Giovanni, Colussi, Arthur, Corradi, Miran, Croda, Julio, 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Dastan, Farzaneh, Ebrahimpour, Soheil, Eghtesad, Sareh, Fallahi, Mohammad Javad, Fallahpoor Golmaee, Fatemeh, Foroghi Ghomi, Seyed Yaser, Ghadir, Mohammad Reza, Gheitani, Mina, Ghiasvand, Fereshteh, Hafizi Lotfabadi, Saied, Hakamifard, Atousa, Hashemi Madani, Shima Sadat, Hormati, Ahmad, Hosseini, Hamed, Janbakhsh, Alireza, Javanian, Mostafa, Joukar, Farahnaz, Kamali, Alireza, Karampour, Amin, Khajavirad, Nasim, Khodabakhshi, Behnaz, Khodadadi, Javad, Khodashahi, Rozita, Kiani Majd, Somaieh, Mahfoozi, Lida, Mahmoodiyeh, Behnam, Mansour-Ghanaei, Fariborz, Mansouri, Feizollah, Mesgarpour, Bita, Mesri, Mehdi, Mikaeili, Haleh, Miladi, Ronak, Moghadami, Mohsen, Mohamadi, Payam, Mohraz, Minoo, Mohseni Afshar, Zeinab, Moogahi, Sasan, Mousavi Anari, Seyed Alireza, Mozaffar, Seyyed Hassan, Mozdourian, Mahnaz, Najafipour, Reza, Najari, Hamidreza, Nazemiyeh, Masoud, Norouzi, Alireza, Pourkazemi, Aydin, Poustchi, Hossein, Saberhosseini, Seyedeh Naeimeh, Saberi, Marzieh, Saber-Moghaddam, Niloufar, Sadeghi, Anahita, Sadeghi Haddad Zavareh, Mahmoud, Sahraian, Mohammad Ali, Salahi, Mehrdad, Salehi, Mohammad Reza, Sarmadian, Hossein, Sayad, Babak, Shirani, Kiana, Shirvani, Maria, Shojaei, Daryanaz, Shokri, Mehran, Siami, Zeinab, Sima, Ali Reza, Soleimani, Alireza, Soltanmohammad, Saedeh, Tabarsi, Payam, Taghizadieh, Ali, Tavassoli, Samaneh, Varnasseri, Mehran, Vaziri, Siavash, Yadyad, Mohammad Jaafar, Yaghoubi, Shoeleh, Yazdanpanah, Yalda, Yousefi, Farid, Zamanian, Mohammad Hossein, Zand, Farid, Zare Hoseinzade, Elham, Bergin, Colm, Cotter, Aoife, de Barra, Eoghan, Jackson, Arthur, Laffey, John, McCarthy, Cormac, Muldoon, Eavan, Sadlier, Corinna, Maguire, Teresa, Angheben, Andrea, Bai, Francesca, Bandera, Alessandra, Barchiesi, Francesco, Bassetti, Matteo, Bisi, Luca, Bonfanti, Paolo, Calò, Federica, Campoli, Caterina, Canovari, Benedetta, Capetti, Amedeo, Castelli, Francesco, Cauda, Roberto, Cingolani, Antonella, Cocco, Nicolò, Coppola, Nicola, Corcione, Silvia, Cremonini, Eleonora, d'Arminio Monforte, Antonella, de Gaetano Donati, Katleen, De Nardo, Pasquale, De Rosa, Francesco Giuseppe, Degioanni, Maria, Della Siega, Paola, Di Bella, Stefano, Drera, Bruno, Focà, Emanuele, Fornabaio, Chiara, Galli, Massimo, Giacomazzi, Donatella, Gori, Andrea, Gustinetti, Giulia, Iannuzzi, Francesca, Kertusha, Blerta, Lamonica, Silvia, Lichtner, Miriam, Lupia, Tommaso, Luzzati, Roberto, Macera, Margherita, Menatti, Elisabetta, Merelli, Maria, Merlini, Esther, Monari, Caterina, Pan, Angelo, Pecori, Davide, Pezzani, Diletta, Riccardi, Niccolò, Rodari, Paola, Roldan, Eugenia, Rovere, Pierangelo, Rusconi, Stefano, Scabini, Silvia, Tascini, Carlo, Viale, Pierluigi, Vincenzi, Marcello, Zuccalà, Paola, Zucchi, Patrizia, Al-Roomi, Moudhi, Al-Sabah, Salman, Schrapp, Kelly, Hassoun, Mahmoud, Matar, Madonna, Dbouni, Oussaima, Yared, Nadine, Saliba, Michele, Farra, Anna, Riachi, Moussa, Zablockiene, Birute, Reuter, Jean, Staub, Therese, Ab Wahab, Suhaila, Chew, Chun Keat, Chua, Hock Hin, Goh, Pik Pin, Lee, Heng Gee, Leong, Chee Loon, Low, Lee Lee, Mak, Wen Yao, Mohamed Gani, Yasmin, Muhamad, Dzawani, Zaidan, Nor Zaila, Ducker, Camilla, Demiri, Ilir, Aballi, Saad, Berg, Åse, Blomberg, Bjørn, Dalgard, Olav, Dyrhol-Riise, Anne Ma, Eiken, Ragnhild, Ernst, Gernot, Hannula, Ranula, Haugli, Metter, Heggelund, Lars, Hoel, Hedda, Hoff, Dag Arne Lihaug, Holten, Aleksander Rygh, Johannessen, Asgeir, Kåsine, Trine, Kildal, Anders Benjamin, Kittang, Bård Reikvam, Nezvalova-Henriksen, Katerina, Olsen, Inge Christoffer, Olsen, Roy Bjørkolt, Skei, Nina Vibeche, Skudal, Hilde, Tholin, Birgitte, Thoresen, Lars, Trøseid, Marius, Tveita, Anders, Vinge, Leif, Ystrøm, Carl Magnus, Al Jahdhami, Issa, AlNaamani, Khalid, Al Balushi, Zakariya, Pandak, Nenad, Abbas, Salma, Akhtar, Nasim, Azam, Sumeyya, Begum, Dilshad, Hassan, Sadia, Herekar, Fivzia, Khan, Shahzaib, Khan, Ejaz Ahmed, Mahmood, Syed Faisal, Nasir, Nosheen, Rahim, Anum, Sarfaraz, Samreen, Shaikh, Qurat-ul-Ain, Sultan, Faisal, Walayat, Usman, Agurto-Lescano, Erika Cecilia, Alcantara-Díaz, Andrés Martín, Alva-Correa, Ana María, Alvarado-Moreno, José Gustavo, Ángeles-Padilla, Bethsabé, Arbañil-Huamàn, Hugo César, Ávila-Reyes, Pool Christopher, Azañero-Haro, Johan Alexander, Barreto-Rocchetti, Luis Guillermo, Benitez-Peche, Jorge Marko A., Bernal-Màlaga, Karla Hortencia, Cabrera-Portillo, Liliana Norma, Carazas-Chavarry, Reynaldo Javier, Càrcamo, Paloma Mariana, Casimiro-Porras, Indira Catalina, Castillo-Espinoza, Jhuliana, Chacaltana-Huarcaya, Jesús Norberto, Cornejo-Valdivia, Carla Raquel, Cruz-Chereque, Augusto, Del-Aguila-Torres, Keith Cayetano Marcelino, Díaz-Chipana, Erika, Flores-Valdez, Neil, Franco-Vàsquez, Rosanna Andrea, Gallegos-López, Roxana Consuelo, Gastiaburú-Rodriguez, Dauma Yesenia, Gianella-Malca, Gonzalo Ernesto, Gomero-Lopez, Andrés Alonso, Hercilla-Vàsquez, Luis Enrique, Hueda-Zavaleta, Miguel Ángel, Ibarcena-Llerena, Claudia Vanessa, Iberico-Barrera, Carlos Alberto, Inquilla-Castillo, Miguel Angel, Juàrez-Eyzaguirre, Jesus Alberto, Laca-Barrera, Manuel, León-Jiménez, Franco, Luna-Wilson, Carla Vanessa, Màlaga, German, Marin, Ricardo, Mejía-Cordero, Fernando, Mendoza-Laredo, Juan Arturo, Meregildo-Rodríguez, Edinson Dante, Miranda-Manrique, Gonzalo Francisco, Olivera-Chaupis, Marco, Ortega-Monasterios, Fatima Josefina, Otazú-Ybàñez, Jimmy Pedro, Paredes-Moreno, María Angélica, Peña-Mayorga, Claudia Ximena, Peña-Vàsquez, Olivia del Carmen, Peña-Villalobos, Alejandro, Ponce, Oscar J, Ponte-Fernandez, Katherin Estefania, Pro, Jose, Quispe-Nolazco, César Miguel, Ramos-Samanez, Manuel Efrain, Rojas-Murrugarra, Kory Mirtha, Samanez-Pérez, Jorge Mauro, Sànchez-Carrillo, Halbert Chrostian, Sànchez-Garavito, Epifanio, Sànchez-Sevillano, Ricardo Manuel, Sandoval-Manrique, Hernan, Santos-Revilla, Gabriela, Silva-Ramos, Julio Antonio, Solano-Ico, Manuel Alberto, Soto, Alonso, Sotomayor-Woolcott, Giannilu Michelle, Tapia-Orihuela, Ruben Kevin Arnold, Terrazas-Obregón, Carmen Sara, Terrones-Levano, Victor Francisco, Ticona-Huaroto, Cesar Eduardo, Torres-Ninapayta, Walter, Torres-Ruiz, Oscar Martin, Ugarte-Mercado, Dario, Vargas-Anahua, Orlando José, Vàsquez-Becerra, Ruben Dario, Vàsquez-Cerro, José Gabriel, Villegas-Chiroque, Miguel, Williams, Anna Larson, Yauri-Lazo, Randi Mauricio, Abad, Cybele Lara, Andales-Bacolcol, Silverose Ann, Arcegono, Marlon, Arches, Jamie, Astudillo, Mary Grace, Aventura, Emily, Awing, Arlyn, Bala, Mishelle Vonnabie, Bello, Jia An, Blanco, Peter, Benedicto, Jubert, Buno, Susana, Cabrera, Justine, Cajulao, Thea Pamela, Caoili, Janice, Casiple-Amsua, Lina, Catambing, Victor, Chin, Inofel, Chua, Ma. Bernadette, Chua, Mitzi Marie, Climacosa, Fresthel Monica, David-Wang, Aileen, De los Reyes, Virginia, Europa, Gilly May, Fernandez, Lenora, Francisco, Jorge, Garcia, Gerard, Garcia, Jemelyn, Gler, Maria Tarcela, Isidro, Marie Grace Dawn, Javier, Rozelle Jade, Kwek, Marion, Lansang, Mary Ann, Lee, Aileen, Li, Kingbherly, Llanes, Mark Ramon Victor, Llorin, Ryan, Macadato, Omar Khayyam, Malundo, Anna Flor, Mercado, Maria Elizabeth, Mujeres, Mercedes, Nepomuceno, Marisse, Ngo-Sanchez, Katha, Orden, Mary Claire, Pablo-Villamor, Maria Philina, Paez, Ruel Dionisio, Palmes, Patricio, Panaligan, Marion, Quinivista-Yoon, Jenny Mae, Ramos, Mary Shiela Ariola, Ramos -Penalosa, Christine, Reyes, Sheila Marie, Roa, Kathryn, Roman, Arthur Dessi, Rosario, Minette Claire, Roxas, Evalyn, Santos, Lourdes Ella Gonzales, Soldevilla, Helmar, Solante, Rontgene, Suaco, Jane, Tagarda, Daisy, Tang, Issa Rufina, Te, Bob, Teo, Dennis, Tibayan, Christopher John, Villalobos, Ralph Elvi, Ymbong, Duane Richard, Zabat, Gelza Mae, Batkova, Stepanka, Cardoso, Orlando, Garrote, Ana-Raquel, Lino, Sara, Manata, Maria-José, Pinheiro, Helder, Póvoas, Diana, Ramirez, Freddy, Seixas, Diana, Naji, Assem, Al Gethamy, M Al, AL-Mulaify, Mohammed Sami, Al Maghraby, Reem, Alrajhi, A, Al Sharidi, Aynaa, Alotaibi, Naif, AlShaharani, F, Barry, Mazin, Ghonem, Leen, Khalel, Anas, Kharaba, Ayman Mohammed, Alabdan, Lulwah, AlAbdullah, Mohammed Sharaf, Al Shabib, Abdullah, Bengu, Simangele, Bennet, Jacklyn, Dubula, Thozama, Howell, Pauline, Janse van Vuuren, Cloete, Kalla, Ismail, Lifson, Aimee, Maasdorp, Shaun, Magua, Nombulelo, Maluleke, Vongani, Mbhele, Nokuphiwa, Mdladla, Nathi, Mendelson, Mark, Menezes, Colin, Mwelase, Thando, Nchabeleng, Maphoshane, Palanee-Phillips, Thesla, Parker, Victoria, Rassool, Mohammed, Reeder, Paul, Sossen, Bianca, Steyn, Dewald, Tsitsi, Merika, van Blydenstein, Sarah Alex, Venter, Michelle, Van Vuuren, Janse, Venturas, Jacquie, Abad Pérez, Daniel, Abenza, Maria José, Alarcón-Payer, Carolina, Armero Garrigos, Eva, Arribas, Jose Ramon, Ascaso, Ana, Berenguer, Juan, Cabello-Clotet, Noemí, Chamorro Tojeiro, Sandra, Cuenca-Acevedo, Rafael, de la Calle, Fernando, Del Toro, Maria Dolores, Díaz Pollàn, Beatriz, Diez, Cristina, Esquillor-Rodrigo, María José, Estrada, Vicente, Fanciulli, Chiara, Fanjul, Francisco, Fernàndez de Orueta, Lucía, Ferre, Adrian, Ferreira Pasos, Eva Maria, Gainzarain-Arana, Juan-Carlos, Garcia, Felipe, García Deltoro, Miguel, Goikoetxea Agirre, Ane Josune, Gómez Barquero, Julia, Gomez-Huelgas, Ricardo, Gonzàlez Moraleja, Julio, Guijarro, Carlos, Gutierrez, Felix, Guzmàn, Jesús, Ibarguren, Maialen, Iribarren, Jose Antonio, Jerusalem, Koen, Juan Arribas, Arturo, Lalueza, A, Leone, Antonio, Lopez Azkarreta, Iñigo, Lozano-Martin, Daniel, Lucendo, Alfredo J, Luengo López, Mariella, Martín Oterino, JA, Masa, JF, Merino, Esperanza, Monge-Maillo, Begoña, Moran-Rodríguez, Miguel-Angel, Muñez Rubio, Elena, Muñoz Sanchez, Josefa, Nuñez Orantos, Maria Jose, Nuño, Enrique, Ortiz-De-Zarate-Ibarra, Zuriñe, Pagàn-Muñoz, Bàrbara, Paño-Pardo, José Ramón, Peñaranda, Maria, Pérez Chica, Gerardo, Pérez Fernàndez, AM, Pérez-López, Carmen, Polo San Ricardo, Victor, Portu-Zapirain, Joseba, Puchades, Francesco, Rivas Paterna, Ana Belen, Rodríguez Vidigal, Francisco F, Rodríguez-Baño, Jesus, Ruiz-Seco, Pilar, Ryan, Pablo, Saez-De-Adana, Ester, Salas, Rosario, Salavert Lletí, Miguel, Sandoval, Raquel, Toyas-Miazza, Carla, Valencia, Jorge, Vargas, Emilio, Velasco, Maria, Von Wichmann, Miguel Angel, Bosshard, Andreas, Calmy, Alexandra, Castro, Tiago, Cavassini, Matthias, Clerc, Olivier, Conen, Anna, Desbaillets, Nicolas, Desgranges, Florian, Duss, Francois, Emonet, Stephane, Erard, Veronique, Eyer, Myriam, Fayet-Mello, Aurélie, Flammer, Yvonne, Friedl, Andrée, Fulchini, Rosamaria, Furrer, Hansjakob, Garin, Nicolas, Gastberger, Salome, Greiner, Michael, Haefliger, David, Haubitz, Sebastian, Hoffmann, Matthias, Isenring, Egon, Jakopp, Barbara, Lampert, Markus, Marinosci, Annalisa, Martin, Yvonne, Petignat, Pierre-Auguste, Piso, Rein Jan, Prendki, Virginie, Rutishauser, Jonas, Schaefer, Elisabeth, Schmiedel, Yvonne, Schwery, Stefan, Stavropoulou, Elisavet, Stoeckle, Marcel, Suttels, Veronique, Thurnher, Maria Christine, van den Bogaart, Lorena, West, Emily, Wiegand, Jan, and Wiggli, Benedikt

Published
2022
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5. 2D kinematic signatures of boxy/peanut bulges

Author

Iannuzzi, Francesca and Athanassoula, E.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We study the imprints of boxy/peanut structures on the 2D line-of-sight kinematics of simulated disk galaxies. The models under study belong to a family with varying initial gas fraction and halo triaxiality, plus few other control runs with different structural parameters; the kinematic information was extracted using the Voronoi-binning technique and parametrised up to the fourth order of a Gauss-Hermite series. Building on a previous work for the long-slit case, we investigate the 2D kinematic behaviour in the edge-on projection as a function of the boxy/peanut strength and position angle; we find that for the strongest structures the highest moments show characteristic features away from the midplane in a range of position angles. We also discuss the masking effect of a classical bulge and the ambiguity in discriminating kinematically this spherically-symmetric component from a boxy/peanut bulge seen end-on. Regarding the face-on case, we extend existing results to encompass the effect of a second buckling and find that this phenomenon spurs an additional set of even deeper minima in the fourth moment. Finally, we show how the results evolve when inclining the disk away from perfectly edge-on and face-on. The behaviour of stars born during the course of the simulations is discussed and confronted to that of the pre-existing disk. The general aim of our study is providing a handle to identify boxy/peanut structure and their properties in latest generation IFU observations of nearby disk galaxies., Comment: 27 pages, 32 figures. Accepted for publication in MNRAS. High-resolution version and supplementary material will be available on the journal's website

Published
2015
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6. Novel Adaptive softening for collisionless N-body simulations: Eliminating spurious halos

Author

Hobbs, Alexander, Read, Justin, Agertz, Oscar, Iannuzzi, Francesca, and Power, Chris

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We describe a NOVel form of Adaptive softening (NovA) for collisionless $N$-body simulations, implemented in the Ramses adaptive mesh refinement code. We introduce a refinement criterion that the particle distribution within each cell be sufficiently isotropic, as measured by its moment of inertia tensor. In this way, collapse is only refined if it occurs along all three axes, ensuring that the softening $\epsilon$ is always of order twice the largest inter-particle spacing in a cell. This more conservative force softening criterion is designed to minimise spurious two-body effects, while maintaining high force resolution in collapsed regions of the flow. We test NovA using an antisymmetric perturbed plane wave collapse (`Valinia' test) before applying it to warm dark matter (WDM) simulations. For the Valinia test, we show that -- unlike the standard $N$-body method -- NovA produces no numerical fragmentation while still being able to correctly capture fine caustics and shells around the collapsing regions. For the WDM simulations, we find that NovA converges significantly more rapidly than standard $N$-body, producing little or no spurious halos on small scales. We show, however, that determining whether or not halos exist below the free streaming mass $M_{\rm fs}$ is complicated by the fact that our halo finder (AHF) likely incorrectly labels some caustics and criss-crossing filaments as halos, while one or two particularly massive filaments appear to fragment in any version of NovA where refinement is allowed. Such massive filaments may be physically unstable to collapse, as is the case for infinite, static, self-gravitating cylinders. We will use NovA in forthcoming papers to study the issue of halo formation below $M_{\rm fs}$; filament stability; and to obtain new constraints on the temperature of dark matter., Comment: 12 pages, 7 figures. To be submitted to MNRAS

Published
2015
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8. Association between perioperative fluid administration and postoperative outcomes: a 20-year systematic review and a meta-analysis of randomized goal-directed trials in major visceral/noncardiac surgery

Author

Messina, Antonio, Robba, Chiara, Calabrò, Lorenzo, Zambelli, Daniel, Iannuzzi, Francesca, Molinari, Edoardo, Scarano, Silvia, Battaglini, Denise, Baggiani, Marta, De Mattei, Giacomo, Saderi, Laura, Sotgiu, Giovanni, Pelosi, Paolo, and Cecconi, Maurizio

Published
2021
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10. The effect of softening on dynamical simulations of galaxies

Author

Iannuzzi, Francesca and Athanassoula, E.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Dynamical simulations are a fundamental tool for studying the secular evolution of disc galaxies. Even at their maximum resolution, they still follow a limited number of particles and typically resolve scales of the order of a few tens of parsecs. Generally, the spatial resolution is defined by (some multiple of) the softening length, whose value is set as a compromise between the desired resolution and the need for limiting small-scale noise. Several works have studied the question whether a softening scale fixed in space and time provides a good enough modelling of an astrophysical system. Here we address this question within the context of dynamical simulations and disc instabilities. We first follow the evolution of a galaxy-like object in isolation and then set up a simulation of an idealised merger event. Alongside a run using the standard fixed-softening approach, we performed simulations where the softening lengths were let to vary from particle to particle according to the evolution of the local density field in space and time. Even though during the most violent phases of the merging the fixed-softening simulation tends to underestimate the resulting matter densities, as far as the evolution of the disc component is concerned we found no significant differences among the runs. We conclude that using an appropriate fixed softening scale is a safe approach to the problem of modelling an N-body, non-cosmological disc galaxy system., Comment: 12 pages, 13 figures. Accepted for publication in MNRAS

Published
2013
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11. The AGORA High-Resolution Galaxy Simulations Comparison Project

Author

Kim, Ji-hoon, Abel, Tom, Agertz, Oscar, Bryan, Greg L., Ceverino, Daniel, Christensen, Charlotte, Conroy, Charlie, Dekel, Avishai, Gnedin, Nickolay Y., Goldbaum, Nathan J., Guedes, Javiera, Hahn, Oliver, Hobbs, Alexander, Hopkins, Philip F., Hummels, Cameron B., Iannuzzi, Francesca, Keres, Dusan, Klypin, Anatoly, Kravtsov, Andrey V., Krumholz, Mark R., Kuhlen, Michael, Leitner, Samuel N., Madau, Piero, Mayer, Lucio, Moody, Christopher E., Nagamine, Kentaro, Norman, Michael L., Oñorbe, Jose, O'Shea, Brian W., Pillepich, Annalisa, Primack, Joel R., Quinn, Thomas, Read, Justin I., Robertson, Brant E., Rocha, Miguel, Rudd, Douglas H., Shen, Sijing, Smith, Britton D., Szalay, Alexander S., Teyssier, Romain, Thompson, Robert, Todoroki, Keita, Turk, Matthew J., Wadsley, James W., Wise, John H., and Zolotov, Adi

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We introduce the AGORA project, a comprehensive numerical study of well-resolved galaxies within the LCDM cosmology. Cosmological hydrodynamic simulations with force resolutions of ~100 proper pc or better will be run with a variety of code platforms to follow the hierarchical growth, star formation history, morphological transformation, and the cycle of baryons in and out of 8 galaxies with halo masses M_vir ~= 1e10, 1e11, 1e12, and 1e13 Msun at z=0 and two different ("violent" and "quiescent") assembly histories. The numerical techniques and implementations used in this project include the smoothed particle hydrodynamics codes GADGET and GASOLINE, and the adaptive mesh refinement codes ART, ENZO, and RAMSES. The codes will share common initial conditions and common astrophysics packages including UV background, metal-dependent radiative cooling, metal and energy yields of supernovae, and stellar initial mass function. These are described in detail in the present paper. Subgrid star formation and feedback prescriptions will be tuned to provide a realistic interstellar and circumgalactic medium using a non-cosmological disk galaxy simulation. Cosmological runs will be systematically compared with each other using a common analysis toolkit, and validated against observations to verify that the solutions are robust - i.e., that the astrophysical assumptions are responsible for any success, rather than artifacts of particular implementations. The goals of the AGORA project are, broadly speaking, to raise the realism and predictive power of galaxy simulations and the understanding of the feedback processes that regulate galaxy "metabolism." The proof-of-concept dark matter-only test of the formation of a galactic halo with a z=0 mass of M_vir ~= 1.7e11 Msun by 9 different versions of the participating codes is also presented to validate the infrastructure of the project., Comment: 21 pages, 6 figures, Accepted for publication in the Astrophysical Journal Supplement, Image resolution greatly reduced, High-resolution version of this article and more information about the AGORA Project including the science goals of the 13 Working Groups are available at http://www.AGORAsimulations.org/ and at http://sites.google.com/site/santacruzcomparisonproject/details/

Published
2013
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12. On the orbital and internal evolution of cluster galaxies

Author

Iannuzzi, Francesca and Dolag, Klaus

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

Galaxies inhabiting a cluster environment experience significant evolution in their orbital motions throughout time; this is accompanied by changes in the anisotropy parameter, measuring the relative importance of radial and tangential motions for a given class of objects. Along with orbital changes, galaxies in clusters are well known to undergo severe alteration in their hot/cold gas content and star formation properties. Understanding the link between the changes in the internal properties of galaxies and their orbital motion is of crucial importance in the study of galaxy evolution, as it could unveil the primary mechanism responsible for its environmental dependence. Do the changes in the internal properties happen in parallel with those in the orbital motion? Or are the orbital features at the time of infall what determines the fate of the member galaxies? Alternatively: are the properties of galaxies at a given time related to the coeval orbital anisotropy or are they better related to the anisotropy at infall? In order to answer these questions, we studied the orbital evolution of different galaxy populations in the semi-analytic models of Guo et al. (2011) applied on to the Millennium Simulation. For each class of objects, characterised by different internal properties (such as age, star formation rate and colour), we studied the anisotropy profile at redshift zero and its evolution by tracing the progenitors back in time. We conclude that the orbital properties at infall strongly influence the subsequent evolution of the internal features of galaxies and that the overall anisotropy of the galaxy population tends to increase with time., Comment: 11 pages, 9 figures. Accepted for publication in MNRAS

Published
2012
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13. Adaptive gravitational softening in GADGET

Author

Iannuzzi, Francesca and Dolag, Klaus

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Cosmological simulations of structure formation follow the collisionless evolution of dark matter starting from a nearly homogeneous field at early times down to the highly clustered configuration at redshift zero. The density field is sampled by a number of particles in number infinitely smaller than those believed to be its actual components and this limits the mass and spatial scales over which we can trust the results of a simulation. Softening of the gravitational force is introduced in collisionless simulations to limit the importance of close encounters between these particles. The scale of softening is generally fixed and chosen as a compromise between the need for high spatial resolution and the need to limit the particle noise. In the scenario of cosmological simulations, where the density field evolves to a highly inhomogeneous state, this compromise results in an appropriate choice only for a certain class of objects, the others being subject to either a biased or a noisy dynamical description. We have implemented adaptive gravitational softening lengths in the cosmological simulation code GADGET; the formalism allows the softening scale to vary in space and time according to the density of the environment, at the price of modifying the equation of motion for the particles in order to be consistent with the new dependencies introduced in the system's Lagrangian. We have applied the technique to a number of test cases and to a set of cosmological simulations of structure formation. We conclude that the use of adaptive softening enhances the clustering of particles at small scales, a result visible in the amplitude of the correlation function and in the inner profile of massive objects, thereby anticipating the results expected from much higher resolution simulations., Comment: 15 pages, 21 figures, 1 table. Accepted for publication in MNRAS

Published
2011
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14. Haloes gone MAD: The Halo-Finder Comparison Project

Author

Knebe, Alexander, Knollmann, Steffen R., Muldrew, Stuart I., Pearce, Frazer R., Aragon-Calvo, Miguel Angel, Ascasibar, Yago, Behroozi, Peter S., Ceverino, Daniel, Colombi, Stephane, Diemand, Juerg, Dolag, Klaus, Falck, Bridget L., Fasel, Patricia, Gardner, Jeff, Gottloeber, Stefan, Hsu, Chung-Hsing, Iannuzzi, Francesca, Klypin, Anatoly, Lukic, Zarija, Maciejewski, Michal, McBride, Cameron, Neyrinck, Mark C., Planelles, Susana, Potter, Doug, Quilis, Vicent, Rasera, Yann, Read, Justin I., Ricker, Paul M., Roy, Fabrice, Springel, Volker, Stadel, Joachim, Stinson, Greg, Sutter, P. M., Turchaninov, Victor, Tweed, Dylan, Yepes, Gustavo, and Zemp, Marcel

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

[abridged] We present a detailed comparison of fundamental dark matter halo properties retrieved by a substantial number of different halo finders. These codes span a wide range of techniques including friends-of-friends (FOF), spherical-overdensity (SO) and phase-space based algorithms. We further introduce a robust (and publicly available) suite of test scenarios that allows halo finder developers to compare the performance of their codes against those presented here. This set includes mock haloes containing various levels and distributions of substructure at a range of resolutions as well as a cosmological simulation of the large-scale structure of the universe. All the halo finding codes tested could successfully recover the spatial location of our mock haloes. They further returned lists of particles (potentially) belonging to the object that led to coinciding values for the maximum of the circular velocity profile and the radius where it is reached. All the finders based in configuration space struggled to recover substructure that was located close to the centre of the host halo and the radial dependence of the mass recovered varies from finder to finder. Those finders based in phase space could resolve central substructure although they found difficulties in accurately recovering its properties. Via a resolution study we found that most of the finders could not reliably recover substructure containing fewer than 30-40 particles. However, also here the phase space finders excelled by resolving substructure down to 10-20 particles. By comparing the halo finders using a high resolution cosmological volume we found that they agree remarkably well on fundamental properties of astrophysical significance (e.g. mass, position, velocity, and peak of the rotation curve)., Comment: 27 interesting pages, 20 beautiful figures, and 4 informative tables accepted for publication in MNRAS. The high-resolution version of the paper as well as all the test cases and analysis can be found at the web site http://popia.ft.uam.es/HaloesGoingMAD

Published
2011
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15. Baryon history and cosmic star formation in non-Gaussian cosmological models: numerical simulations

Author

Maio, Umberto and Iannuzzi, Francesca

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, Mathematical Physics
Abstract

We present the first numerical, N-body, hydrodynamical, chemical simulations of cosmic structure formation in the framework of non-Gaussian models. We study the impact of primordial non-Gaussianities on early chemistry (e, H, H+, H-, He, He+, He++, H2, H2+, D, D+, HD, HeH+), molecular and atomic gas cooling, star formation, metal (C, O, Si, Fe, Mg, S) enrichment, population III (popIII) and population II-I (popII) transition, and on the evolution of "visible" objects. We find that non-Gaussianities can have some consequences on baryonic structure formation at very early epochs, but the subsequent evolution at later times washes out any difference among the various models. When assuming reasonable values for primordial non-Gaussian perturbations, it turns out that they are responsible for: (i) altering early molecular fractions in the cold, dense gas phase of ~10 per cent; (ii) inducing small temperature fluctuations of <~10 per cent during the cosmic evolution of primordial objects; (iii) influencing the onset of the first star formation events, at z>~15, and of the popIII/popII transition of up to some 10^7yr; (iv) determining variations of <~10 per cent in the gas cloud and stellar mass distributions after the formation of the first structures; (v) causing only mild variations in the chemical history of the Universe. We stress, though, that purely non-Gaussian effects might be difficult to address, since they are strictly twisted with additional physical phenomena (e.g. primordial gas bulk flows, unknown primordial popIII stellar mass function, etc.) that have similar or stronger impact on the behaviour of the baryons., Comment: Accepted for publications on MNRAS, on April 13, 2011. Minor revisions

Published
2011
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16. Early prone positioning does not improve the outcome of patients with mild pneumonia due to SARS-CoV-2: results from an open-label randomised controlled trial – the EPCoT study

Author

Fezzi, Miriam, primary, Antolini, Laura, additional, Soria, Alessandro, additional, Bisi, Luca, additional, Iannuzzi, Francesca, additional, Sabbatini, Francesca, additional, Rossi, Marianna, additional, Limonta, Silvia, additional, Rugova, Alban, additional, Columpsi, Paola, additional, Squillace, Nicola, additional, Foresti, Sergio, additional, Pollastri, Ester, additional, Valsecchi, Maria Grazia, additional, Migliorino, Guglielmo Marco, additional, Bonfanti, Paolo, additional, and Lapadula, Giuseppe, additional

Published
2023
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17. Do statins decrease vascular inflammation in patients at risk for large-vessel vasculitis? A retrospective observational study with FDG-PET/CT in polymyalgia rheumatica, giant cell arteritis and fever of unknown origin

Author

Iannuzzi, Francesca, primary, Hysa, Elvis, additional, Camellino, Dario, additional, Morbelli, Silvia, additional, Bauckneht, Matteo, additional, Sambuceti, Gianmario, additional, Cutolo, Maurizio, additional, and Cimmino, Marco Amedeo, additional

Published
2023
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18. Early prone positioning does not improve the outcome of patients with mild pneumonia due to SARS-CoV-2: results from an open-label, randomised controlled trial (the EPCoT Study)

Author

Fezzi, Miriam, Antolini, Laura, Soria, Alessandro, Bisi, Luca, Iannuzzi, Francesca, Sabbatini, Francesca, Rossi, Marianna, Limonta, Silvia, Rugova, Alban, Columpsi, Paola, Squillace, Nicola, Foresti, Sergio, Pollastri, Ester, Valsecchi, Maria Grazia, Migliorino, Guglielmo Marco, Bonfanti, Paolo, Lapadula, Giuseppe, Fezzi, M, Antolini, L, Soria, A, Bisi, L, Iannuzzi, F, Sabbatini, F, Rossi, M, Limonta, S, Rugova, A, Columpsi, P, Squillace, N, Foresti, S, Pollastri, E, Valsecchi, M, Migliorino, G, Bonfanti, P, and Lapadula, G

Subjects
COVID-19
Abstract

Background: Prone positioning (PP) is routinely used among patients with COVID-19 requiring mechanical ventilation (MV). However, its utility among spontaneously breathing patients is still debated. Methods: In an open-label randomised controlled trial, we enrolled patients hospitalised with mild COVID-19 pneumonia, whose PaO2/FiO2 ratio (P/F) was >200 mmHg and who did not require MV or Continuous Positive Airway Pressure (CPAP) at hospital admission. Patients were randomised 1:1 to PP on top of standard of care (intervention group) versus standard of care only (controls). The primary composite outcome included death, MV, CPAP and P/F

Published
2023

22. Additional file 1 of Effects of positive end-expiratory pressure on lung ultrasound patterns and their correlation with intracranial pressure in mechanically ventilated brain injured patients

Author

Robba, Chiara, Ball, Lorenzo, Battaglini, Denise, Iannuzzi, Francesca, Brunetti, Iole, Fiaschi, Pietro, Zona, Gianluigi, Taccone, Fabio Silvio, Messina, Antonio, Mongodi, Silvia, and Pelosi, Paolo

Abstract

Additional file 1. STROBE, additional information on data analysis, methods, and additional results.

Published
2022
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24. Gestione clinica della malaria nel paziente HIV positivo

Author

Iannuzzi Francesca, Bisi Luca, Bonfanti Paolo, Iannuzzi, F, Bisi, L, and Bonfanti, P

Subjects
HIV, Interazioni farmacologiche, Malaria
Abstract

Vi è un’estesa sovrapposizione geografica tra malaria e infezione da HIV nell’Africa Sub-Sahariana e, in minor misura, nel Sud-Est Asiatico. In Europa e Nord America i casi di malaria nei pazienti HIV positivi sono limitati ai viaggiatori in aree malariche senza idonea profilassi. La co-infezione malaria-HIV (CMH) comporta un aumento della viremia e una riduzione del numero dei linfociti CD4+, l’incremento della parassitemia e della frequenza di gametocitemia persistente, più frequenti complicanze da malaria grave e mortalità più elevata. La CMH in gravidanza aumenta il rischio di complicanze perinatali (parto pre-termine, aumentata mortalità neonatale, anemia grave). Nella scelta del trattamento antimalarico è necessario tenere in considerazione le numerose interazioni farmacologiche con la terapia antiretrovirale. In generale gli inibitori delle proteasi e gli NNRTI sono i farmaci con il maggior numero di interazioni farmacologiche con le terapie di combinazione a base di derivati dell’artemisinina. L’allungamento del tratto QT è l’evento avverso più frequente e che richiede un monitoraggio ECG più attento nei pazienti in trattamento antiretrovirale. Il paziente con infezione da HIV necessita pertanto un attento monitoraggio degli effetti collaterali in corso di terapia e rivalutazione nelle settimane successive per assicurarsi l’efficacia del trattamento antimalarico. There is extensive geographical overlap between malaria and HIV infection in Sub-Saharan Africa and, to a lesser extent, Southeast Asia. In Europe and North America, malaria cases in HIV-positive patients are limited to travellers in malarial areas without appropriate prophylaxis. Malaria-HIV co-infection (MHC) results in increased viremia and reduced CD4+ counts, increased parasitaemia and frequency of persistent gametocytaemia, more frequent severe malaria complications and higher mortality. MHC in pregnancy increases the risk of perinatal complications (pre-term delivery, increased neonatal mortality, severe anaemia). Numerous drug interactions with antiretroviral therapy must be considered when choosing antimalarial treatment. In general, protease inhibitors and NNRTIs are the antiretrovirals with the highest number of drug interactions with artemisinin-based combination therapies. QT prolongation is the most frequent adverse event, requiring closer ECG monitoring in patients on antiretroviral therapy. MHC patients therefore need careful monitoring of side effects during therapy and closer follow-up to ensure successful antimalarial treatment.

Published
2021

27. Cerebral Autoregulation in Non-Brain Injured Patients: A Systematic Review

Author

Longhitano, Yaroslava, primary, Iannuzzi, Francesca, additional, Bonatti, Giulia, additional, Zanza, Christian, additional, Messina, Antonio, additional, Godoy, Daniel, additional, Dabrowski, Wojciech, additional, Xiuyun, Li, additional, Czosnyka, Marek, additional, Pelosi, Paolo, additional, Badenes, Rafael, additional, and Robba, Chiara, additional

Published
2021
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29. Tracheostomy Timing and Outcome in Severe COVID-19: The WeanTrach Multicenter Study

Author

Battaglini, Denise, primary, Missale, Francesco, additional, Schiavetti, Irene, additional, Filauro, Marta, additional, Iannuzzi, Francesca, additional, Ascoli, Alessandro, additional, Bertazzoli, Alberto, additional, Pascucci, Federico, additional, Grasso, Salvatore, additional, Murgolo, Francesco, additional, Binda, Simone, additional, Maraggia, Davide, additional, Montrucchio, Giorgia, additional, Sales, Gabriele, additional, Pascarella, Giuseppe, additional, Agrò, Felice Eugenio, additional, Faccio, Gaia, additional, Ferraris, Sandra, additional, Spadaro, Savino, additional, Falò, Giulia, additional, Mereto, Nadia, additional, Uva, Alessandro, additional, Maugeri, Jessica Giuseppina, additional, Agrippino, Bellissima, additional, Vargas, Maria, additional, Servillo, Giuseppe, additional, Robba, Chiara, additional, Ball, Lorenzo, additional, Mora, Francesco, additional, Signori, Alessio, additional, Torres, Antoni, additional, Giacobbe, Daniele Roberto, additional, Vena, Antonio, additional, Bassetti, Matteo, additional, Peretti, Giorgio, additional, Rocco, Patricia R. M., additional, and Pelosi, Paolo, additional

Published
2021
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30. Additional file 1 of Association between perioperative fluid administration and postoperative outcomes: a 20-year systematic review and a meta-analysis of randomized goal-directed trials in major visceral/noncardiac surgery

Author

Messina, Antonio, Robba, Chiara, Calabrò, Lorenzo, Zambelli, Daniel, Iannuzzi, Francesca, Molinari, Edoardo, Scarano, Silvia, Battaglini, Denise, Baggiani, Marta, Mattei, Giacomo De, Saderi, Laura, Sotgiu, Giovanni, Pelosi, Paolo, and Cecconi, Maurizio

Abstract

Additional file 1. Table S1: PRISMA-DTA checklist. Table S2: Extracted data in each study assessed for eligibility. Table S3: Full text articles excluded, not fitting eligibility criteria. Table S4: Summary of perioperative cumulative fluid balance in the included studies. Table S5: Renal complications. Table S6: Cardiovascular complications. Table S7: Pulmonary complications. Table S8: Neurological complications. Table S9: Infective complications. Figure S1: Risk of bias assessment of the included studies. Figure S2: Bias assessment plot. Overall complications. Figure S3: Bias assessment plot. Overall mortality.

Published
2021
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31. Additional file 1 of Perioperative liberal versus restrictive fluid strategies and postoperative outcomes: a systematic review and metanalysis on randomised-controlled trials in major abdominal elective surgery

Author

Messina, Antonio, Robba, Chiara, Calabrò, Lorenzo, Zambelli, Daniel, Iannuzzi, Francesca, Molinari, Edoardo, Scarano, Silvia, Battaglini, Denise, Baggiani, Marta, De Mattei, Giacomo, Saderi, Laura, Sotgiu, Giovanni, Pelosi, Paolo, and Cecconi, Maurizio

Abstract

Additional file 1. Supplementary materials including supplementary tables and figures.

Published
2021
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32. Remdesivir Use in Patients Requiring Mechanical Ventilation due to COVID-19

Author

Lapadula, Giuseppe, Bernasconi, Davide Paolo, Bellani, Giacomo, Soria, Alessandro, Rona, Roberto, Bombino, Michela, Avalli, Leonello, Rondelli, Egle, Cortinovis, Barbara, Colombo, Enrico, Valsecchi, Maria Grazia, Migliorino, Guglielmo Marco, Bonfanti, Paolo, Foti, Giuseppe, Gambaro, Alessandra, Spolti, Anna, Beretta, Ilaria, Bisi, Luca, Cappelletti, Anna, Chiesa, Elisabetta, Cogliandro, Viola, Columpsi, Paola, Foresti, Sergio, Gustinetti, Giulia, Iannuzzi, Francesca, Pollastri, Ester, Rossi, Marianna, Sabbatini, Francesca, Squillace, Nicola, Ferlicca, Daniela, Mauri, Fabrizia, Giani, Marco, Pozzi, Matteo, Russotto, Vincenzo, Lapadula, G, Bernasconi, D, Bellani, G, Soria, A, Rona, R, Bombino, M, Avalli, L, Rondelli, E, Cortinovis, B, Colombo, E, Valsecchi, M, Migliorino, G, Bonfanti, P, and Foti, G

Subjects
Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, critically ill patients, antiviral treatment, coronavirus, remdesivir, 030204 cardiovascular system & hematology, intensive care unit, law.invention, Major Articles, 03 medical and health sciences, 0302 clinical medicine, COVID-19, SARS-CoV-2, Interquartile range, law, Medicine, 030212 general & internal medicine, Survival analysis, Mechanical ventilation, Proportional hazards model, business.industry, Hazard ratio, Intensive care unit, Infectious Diseases, AcademicSubjects/MED00290, Oncology, Anesthesia, Cohort, business
Abstract

Background Remdesivir has been associated with accelerated recovery of severe coronavirus disease 2019 (COVID-19). However, whether it is also beneficial in patients requiring mechanical ventilation is uncertain. Methods All consecutive intensive care unit (ICU) patients requiring mechanical ventilation due to COVID-19 were enrolled. Univariate and multivariable Cox models were used to explore the possible association between in-hospital death or hospital discharge, considered competing-risk events, and baseline or treatment-related factors, including the use of remdesivir. The rate of extubation and the number of ventilator-free days were also calculated and compared between treatment groups. Results One hundred thirteen patients requiring mechanical ventilation were observed for a median of 31 days of follow-up; 32% died, 69% were extubated, and 66% were discharged alive from the hospital. Among 33 treated with remdesivir (RDV), lower mortality (15.2% vs 38.8%) and higher rates of extubation (88% vs 60%), ventilator-free days (median [interquartile range], 11 [0–16] vs 5 [0–14.5]), and hospital discharge (85% vs 59%) were observed. Using multivariable analysis, RDV was significantly associated with hospital discharge (hazard ratio [HR], 2.25; 95% CI, 1.27–3.97; P = .005) and with a nonsignificantly lower mortality (HR, 0.73; 95% CI, 0.26–2.1; P = .560). RDV was also independently associated with extubation (HR, 2.10; 95% CI, 1.19–3.73; P = .011), which was considered a competing risk to death in the ICU in an additional survival model. Conclusions In our cohort of mechanically ventilated patients, RDV was not associated with a significant reduction of mortality, but it was consistently associated with shorter duration of mechanical ventilation and higher probability of hospital discharge, independent of other risk factors.

Published
2020

33. Neurological Complications and Noninvasive Multimodal Neuromonitoring in Critically Ill Mechanically Ventilated COVID-19 Patients

Author

Battaglini, Denise, primary, Santori, Gregorio, additional, Chandraptham, Karthikka, additional, Iannuzzi, Francesca, additional, Bastianello, Matilde, additional, Tarantino, Fabio, additional, Ball, Lorenzo, additional, Giacobbe, Daniele Roberto, additional, Vena, Antonio, additional, Bassetti, Matteo, additional, Inglese, Matilde, additional, Uccelli, Antonio, additional, Rocco, Patricia Rieken Macedo, additional, Patroniti, Nicolò, additional, Brunetti, Iole, additional, Pelosi, Paolo, additional, and Robba, Chiara, additional

Published
2020
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34. Neurological Complications and Noninvasive Multimodal Neuromonitoring in Critically ill COVID-19 Patients

Author

Battaglini, Denise, primary, Santori, Gregorio, additional, Chandraptham, Karthikka, additional, Iannuzzi, Francesca, additional, Bastianello, Matilde, additional, Tarantino, Fabio, additional, Ball, Lorenzo, additional, Giacobbe, Daniele Roberto, additional, Vena, Antonio, additional, Bassetti, Matteo, additional, Rocco, Patricia Rieken Macedo, additional, Patroniti, Nicolò, additional, Brunetti, Iole, additional, Pelosi, Paolo, additional, and Robba, Chiara, additional

Published
2020
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36. Viro‐immunological characterization of naïve patients with high cerebrospinal fluid (CSF) HIV RNA

Author

Iannuzzi, Francesca, Bai, Francesca, Merlini, Esther, Trunfio, Mattia, Borghi, Lidia, Bini, Teresa, Monforte, Antonella D'Arminio, and Carla, Giulia Marchetti

Subjects
Antiviral agents -- Patient outcomes, Viremia -- Measurement, Cerebrospinal fluid -- Testing, HIV infection -- Development and progression -- Drug therapy, Health
Abstract

Background: HIV can spread into the central nervous system (CNS) early in the course of infection and this turns into intrathecal inflammation and neuronal damage. We aimed to investigate clinical and immunological parameters associated with elevated CSF VL in HIV‐infected ART‐naïve patients. Materials and Methods: HIV+ ART‐naïve patients underwent a comprehensive battery of neurocognitive (NC) tests and lumbar puncture (LP) for CSF HIV‐RNA detection. Plasma HIV‐RNA and peripheral T‐cell immune‐phenotypes (CD38/CD45RA/CD45R0/CD127 on CD4/CD8) were also assessed (flow cytometry). High‐CSF HIV RNA was defined as≥10000cp/mL (H‐CSF), while CSF HIV RNA Results: A total of 131 patients were retrospectively enrolled. Forty‐two patients (32%) had CSF VL >10000 cp/mL. Table 1 shows the features of H‐ versus L‐CSF patients. Compared to L‐CSF patients, H‐CSF patients displayed lower current CD4+%, lower CD4/CD8 ratio and higher CD8%. No differences in NC tests performance were observed between groups (p=0.6). Regarding T‐cell immuno‐phenotypes, H‐CSF patients displayed a higher proportion of CD45R0+CD38+CD8+ (11 vs 7%, p=0.02) and lower expression of CD45RA+CD8+ % (16 vs 20%, p=0.007), in comparison to L‐CSF patients. In multivariate analysis CD45RA+CD8+ T‐cells % (OR 0.917, CI 95% 0.852–0.987, p=0.002) was associated with H‐CSF, even after adjustment for plasma VL, CD8 and CD4 count. Globally, in univariate CSF VL inversely correlated with CD45RA+CD8+ % (r=−0.223, p=0.0217) and CD127+CD4+ % (r= −0.204, p= 0.0225), while a positive association was found between CSF and plasma VL (r=0.303, p=0.0004) and CD8 % (r=0.211, p=0.016). In multivariate linear regression, in addition to positive association between plasma and CSF VL (β: 0.212, 95% CI 0.02–0.41, p=0.032), also CD45RA+CD8+ % were confirmed inversely associated to CSF VL (β: 0.21, 95% CI −0.5 to −0.002, p=0.036), adjusting for CD4/CD8 and CD4CD127 %. Conclusions: We hereby describe a 32% prevalence of H‐CSF in a cohort of HIV+ ART‐naïve patients. Subjects with high‐CSF viral replication are mostly with higher systemic immune activation, in particular the percentage of naïve CD8 T‐cell is positively associated with CSF VL, irrespective of plasma VL. In HIV+ ART‐naïve patients, especially if featuring a hyperactivated T‐cell immune‐phenotype, lumbar puncture should be considered to further guide CNS‐targeted cART., Table 1: Demographic and immune‐virological characteristics of the study population and comparison between H‐CSF and L‐CSF patients Tot naïve n=131 CSF‐HIV‐RNA CSF‐HIV_RNA >=10000 cp/mL (H‐CSF pts) (n=42) P value Female, [...]

Published
2014
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37. Plasma miRNA‐based signatures in CRC screening programs

Author

Zanutto, Susanna, primary, Ciniselli, Chiara Maura, additional, Belfiore, Antonino, additional, Lecchi, Mara, additional, Masci, Enzo, additional, Delconte, Gabriele, additional, Primignani, Massimo, additional, Tosetti, Giulia, additional, Dal Fante, Marco, additional, Fazzini, Linda, additional, Airoldi, Aldo, additional, Vangeli, Marcello, additional, Turpini, Francesca, additional, Rubis Passoni, Giovanni Giuseppe, additional, Viaggi, Paolo, additional, Arena, Monica, additional, Motta, Roberta Ilaria Olimpia, additional, Cantù, Anna Maria, additional, Crosta, Cristiano, additional, De Roberto, Giuseppe, additional, Iannuzzi, Francesca, additional, Cassinotti, Andrea, additional, Dall'Olio, Valentina, additional, Tizzoni, Laura, additional, Sozzi, Gabriella, additional, Meroni, Emanuele, additional, Bisanti, Luigi, additional, Pierotti, Marco Alessandro, additional, Verderio, Paolo, additional, and Gariboldi, Manuela, additional

Published
2019
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38. Schwann cell hamartoma: case report

Author

Bulfamante Gaetano, Di Nuovo Franca, Braidotti Paola, Moneghini Laura, Falleni Monica, Iannuzzi Francesca, Dell'Era Alessandra, Rocco Elena, and Romagnoli Solange

Subjects
Schwann cell, hamartoma, schwannoma, gastrointestinal stromal tumors, colonic polyp, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Background Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening. Case presentation We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract. Conclusion As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.

Published
2011
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39. Haloes gone MAD?: The Halo-Finder Comparison ProjectThe Halo-Finder Comparison Project

Author

Knebe Alexander, Knollmann Steffen R., Muldrew Stuart I., Pearce Frazer R., Aragon-Calvo Miguel Angel, Ascasibar Yago, Behroozi Peter S., Ceverino Daniel, Colombi Stephane, Diemand Juerg, Dolag Klaus, Falck Bridget L., Fasel Patricia, Gardner Jeff, Gottlöber Stefan, Hsu Chung-Hsing, Iannuzzi Francesca, Klypin Anatoly, Lukic Zarija, Maciejewski Michal, McBride Cameron, Neyrinck Mark C., Planelles Susana, and Potter Doug

Published
2011
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42. Endoscopic submucosal dissection versus endoscopic mucosal resection for type 0-II superficial gastric lesions larger than 20 mm.

Author

Gambitta, Pietro, Iannuzzi, Francesca, Ballerini, Alessandro, D'Alessandro, Alessandra, Vertemati, Maurizio, Bareggi, Emilia, Pallotta, Stefano, Fontana, Paola, and Aseni, Paolo

Subjects
*GASTRECTOMY, *GASTROINTESTINAL diseases, *CHI-squared test
Abstract

Background Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are increasingly used for the treatment of superficial gastrointestinal neoplasia. However, the limits and the indications for each technique are still debated. Our retrospective study aimed to compare these techniques in patients with gastric flat lesions larger than 20 mm without the nonlifting sign. Methods Between January 2013 and July 2016, a total of 36 patients with early gastric flat lesions larger than 20 mm and without the non-lifting sign were resected by ESD and were followed up by endoscopy. As a control group, 40 EMR cases from our database were matched. En bloc and curative resection were compared between the two groups according to histological assessment, tumor size, recurrence, complication rate, and procedure time. A Kaplan-Meier comparison was performed for both groups with a log-rank test to compare the survival curves; the chi-square test was employed for other parameters. Results En bloc resection rate and curative resection rate were significantly higher in the ESD group than in the EMR group. Procedure time was significantly longer in the ESD group. No significant differences were found in the recurrence and complication rates, although the former were higher in the EMR group and the latter in the ESD group. Survival curves were similar for both groups. Conclusions Our retrospective analysis seems to confirm a clear advantage for ESD over EMR in removing early superficial gastric neoplasm. Although ESD has expanded the endoscopic resectability of endoscopic gastric lesions, EMR may still be considered one of the therapeutic options for flat gastric lesions without the non-lifting sign. [ABSTRACT FROM AUTHOR]

Published
2018
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43. STUDIO SULL'EFFICACIA DELLA TERAPIA ANTICOAGULANTE NEI PAZIENTI CON TROMBOSI PORTALE AFFETTI DA CIRROSI EPATICA

Author

IANNUZZI, FRANCESCA

Abstract

Background & Aims: Portal Vein thrombosis defines the presence of a thrombus, blocking completely or partially the vein in the trunck of the portal vein or in its intrahepatic collaterals . For patients whit cirrhosis, it means a preexisting HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed?term=hypertension%20portal&cmd=correctspelling" portal hypertension getting worth adding a presinusoidal part to it. The TP, if complete, can block the liver transplantation. The aim of this study is to check the efficiency of the anticoagulant oral therapy with heparina in a group of patients affected with epathic cyrrhosis or TP, to value the symptoms of occurances of the TP and the variations of the Child-Pugh score according to the appearance of the resolution or the eventual extension of the TP. Methods: This study has been established in a consecutive range of 66 patients enroled retrospectively, affected with CE and trombose of the Portal system, referred to our unit from January 1996 and April 2010. These patients were followed whit blood exams, abdomen ultrasound computerized axial tomogrphy,endoscopy. Results: At the time of the TP diagnosis, 17% of the patients belonged to the Child-Pugh A class, 68% to the Child-Pugh B class and 6% to the Child-Pugh C class. 44 Patients (66,7%) has done anticoagulant oral therapy, 17(39%) patients were following the terapia con eparina a basso peso molecolare, 23(52%) patients were following a therapy with Coumadin and 4(9%) were following both therapy alternatively. Average time of treatment was 38 � 4 months for the group taking Coumadin, 23 � 3 months for the group taking Eparina a basso peso molecolare. 2 patients were taking eparina for 8 � 1 months and then 39 � 15 months. 2 patients were taking Coumadin for 5 � 2 months and then eparina for 13 � 5 mesi. During the follow-up, 24 patients out of 66 (36%) have obtained a complete resolution( 4 patients without therapy and 20 taking an anticoagulant treatment : 4 patients in therapy with heparin, 12 patients with Coumadin, 4 patients with both simultaneously.) The partial recanalization was obtained for 28 patients (42%) (4 patients without therapy, 24 patients under an anticoagulant therapy : 8 patients following a therapy with heparin, 14 following a therapy with Coumadin and 2 following both at the same time. We can observe an extansion for the trombose for 31 patients out of 66 (47%) from which 25 outside of the anticoagulant therapy and 6 during it (2 patients following the heparin therapy, 3 patients with Coumadin and 1 patient following both simultaneously. 20 patients had portal cavernous (for 7 patients it was already diagnosed, for 13 patients it appeared during the follow-up from which 4 patients were not following any therapy, 5 an heparin therapy, 3 an Coumadin therapy and 1 both simultaneously. Conclusions: The anticoagulant therapy were proved efficient in the recanalization of the TP during the follow-up (p=0,032). The anticoagulant therapy were proved efficient in the partial recanalization of the portal vein thrombosis (p=0,018). Undertaking the anticoagulant therapy did not have a significative impact on the progression of portal vein thrombosis (p=0,168) at the follow-up. The anticoagulant therapy did not prevent the develop of caverous (p=0,741).

Published
2012
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47. NOVel Adaptive softening for collisionless N-body simulations: eliminating spurious haloes.

Author

Hobbs, Alexander, Read, Justin I., Agertz, Oscar, Iannuzzi, Francesca, and Power, Chris

Subjects
GALACTIC halos, ADAPTIVE computing systems, COLLISIONLESS plasmas, MANY-body problem, EIGENVALUES, DARK matter
Abstract

We describe a NOVel form of Adaptive softening (NOVA) for collisionless N-body simulations, implemented in the RAMSES adaptive mesh refinement code. In RAMSES - that we refer to as a 'standard N-body method' - cells are only split if they contain more than eight particles (a mass refinement criterion). Here, we introduce an additional criterion that the particle distribution within each cell be sufficiently isotropic, as measured by the ratio of the maximum to minimum eigenvalues of its moment of inertia tensor: η = λmax/λmin. In this way, collapse is only refined if it occurs along all three axes, ensuring that the softening is always of order twice the largest interparticle spacing in a cell. This more conservative force softening criterion is designed to minimize spurious two-body effects, while maintaining high force resolution in collapsed regions of the flow. We test NOVA using an antisymmetric perturbed plane wave collapse ('Valinia' test) before applying it to warm dark matter (WDM) simulations. For the Valinia test, we show that - unlike the standard N-body method - NOVA produces no numerical fragmentation while still being able to correctly capture fine caustics and shells around the collapsing regions. For the WDM simulations, we find that NOVA converges significantly more rapidly than standard N-body, producing little or no spurious haloes on small scales. We will use NOVA in forthcoming papers to study the issue of halo formation below the free-streaming mass Mfs; filament stability; and to obtain new constraints on the temperature of dark matter. [ABSTRACT FROM AUTHOR]

Published
2016
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