288 results on '"Iannuzzo, G."'
Search Results
2. Come superare le barriere all'implementazione delle strategie di prevenzione e cura della malattia cardiovascolare aterosclerotica mediante terapia ipolipemizzante
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Arca, M, Averna, M, Borghi, C, Lettino, M, Filardi, P, Alberti, A, Bilato, C, Calabrò, P, Carubbi, F, Ciccone, M, Cipollone, F, Citroni, N, De Luca, L, Giaccari, A, Iannuzzo, G, Maloberti, A, Marcucci, R, Spinazzola, P, Pirro, M, Pisciotta, L, Sarullo, F, Sciacqua, A, Suppressa, P, Varbella, F, Werba, J, Zambon, A, Arca M., Averna M., Borghi C., Lettino M., Filardi P. P., Alberti A., Bilato C., Calabrò P., Carubbi F., Ciccone M. M., Cipollone F., Citroni N., De Luca L., Giaccari A., Iannuzzo G., Maloberti A., Marcucci R., Spinazzola P. P., Pirro M., Pisciotta L., Sarullo F., Sciacqua A., Suppressa P., Varbella F., Werba J. P., Zambon A., Arca, M, Averna, M, Borghi, C, Lettino, M, Filardi, P, Alberti, A, Bilato, C, Calabrò, P, Carubbi, F, Ciccone, M, Cipollone, F, Citroni, N, De Luca, L, Giaccari, A, Iannuzzo, G, Maloberti, A, Marcucci, R, Spinazzola, P, Pirro, M, Pisciotta, L, Sarullo, F, Sciacqua, A, Suppressa, P, Varbella, F, Werba, J, Zambon, A, Arca M., Averna M., Borghi C., Lettino M., Filardi P. P., Alberti A., Bilato C., Calabrò P., Carubbi F., Ciccone M. M., Cipollone F., Citroni N., De Luca L., Giaccari A., Iannuzzo G., Maloberti A., Marcucci R., Spinazzola P. P., Pirro M., Pisciotta L., Sarullo F., Sciacqua A., Suppressa P., Varbella F., Werba J. P., and Zambon A.
- Abstract
Atherosclerotic cardiovascular diseases remain the main cause of mortality worldwide, due to a poor control of modifiable risk factors for atherosclerosis. High levels of low-density lipoprotein cholesterol represent the most relevant actor in the development of atherosclerotic cardiovascular diseases, as well as the main target promuovoof prevention strategies. Although lipid-lowering treatments were shown to be effective for cardiovascular prevention, several barriers (e.g. clinician reluctance to prescribe an intensive treatment, poor adherence of patients to therapy, high pharmacotherapy burden of high-risk patients and the fear for adverse events potentially associated with statins) still prevent therapy optimization. Such issues will be addressed in this review article, taking into account possible strategies for their solution, through an integrated approach including both management interventions and a larger use of the available pharmacologic options.
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- 2023
3. Efficacy, safety, adherence and persistence of PCSK9 inhibitors in clinical practice: A single country, multicenter, observational study (AT-TARGET-IT)
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Gargiulo, P, Basile, C, Cesaro, A, Marzano, F, Buonocore, D, Asile, G, Abbate, V, Vicidomini, F, Paolillo, S, Spaccarotella, C, Catalano, A, Spirito, G, Merlini, P, Maloberti, A, Iannuzzo, G, Ciccone, M, Zito, A, Paloscia, L, D'Alleva, A, Varbella, F, Corleto, A, Brunetti, N, Corbo, M, Calabro, P, Indolfi, C, Perrone-Filardi, P, Gargiulo P., Basile C., Cesaro A., Marzano F., Buonocore D., Asile G., Abbate V., Vicidomini F., Paolillo S., Spaccarotella C. A. M., Catalano A., Spirito G., Merlini P. A., Maloberti A., Iannuzzo G., Ciccone M. M., Zito A. P., Paloscia L., D'Alleva A., Varbella F., Corleto A., Brunetti N. D., Corbo M. D., Calabro P., Indolfi C., Perrone-Filardi P., Gargiulo, P, Basile, C, Cesaro, A, Marzano, F, Buonocore, D, Asile, G, Abbate, V, Vicidomini, F, Paolillo, S, Spaccarotella, C, Catalano, A, Spirito, G, Merlini, P, Maloberti, A, Iannuzzo, G, Ciccone, M, Zito, A, Paloscia, L, D'Alleva, A, Varbella, F, Corleto, A, Brunetti, N, Corbo, M, Calabro, P, Indolfi, C, Perrone-Filardi, P, Gargiulo P., Basile C., Cesaro A., Marzano F., Buonocore D., Asile G., Abbate V., Vicidomini F., Paolillo S., Spaccarotella C. A. M., Catalano A., Spirito G., Merlini P. A., Maloberti A., Iannuzzo G., Ciccone M. M., Zito A. P., Paloscia L., D'Alleva A., Varbella F., Corleto A., Brunetti N. D., Corbo M. D., Calabro P., Indolfi C., and Perrone-Filardi P.
- Abstract
Background and aims: Proprotein Convertase Subtilisin/Kexin type 9 inhibitors (PCSK9i) are recommended in patients at high and very-high cardiovascular (CV) risk, with documented atherosclerotic CV disease (ASCVD), and for very-high risk patients with familial hypercholesterolaemia not achieving LDL-cholesterol (LDL-C) goal while receiving maximally tolerated dose of lipid-lowering therapy (LLT). However, single country real-life data, reporting the use of PCSK9i in clinical practice, are limited. Therefore, we designed AT-TARGET-IT, an Italian, multicenter, observational registry on the use of PCSK9i in clinical practice. Methods: All data were recorded at the time of the first prescription and at the latest observation preceding inclusion in the study. Results: 798 patients were enrolled. The median reduction in LDL-C levels was 64.9%. After stratification for CV risk, 63.8% achieved LDL-C target; of them, 83.3% took LLTs at PCSK9i initiation and 16.7% did not. 760 patients (95.2%) showed high adherence to therapy, 13 (1.6%) partial adherence, and 25 (3.1%) poor adherence. At 6 months, 99.7% of patients enrolled in the study remained on therapy; there were 519 and 423 patients in the study with a follow-up of at least 12 and 18 months, respectively. Persistence in these groups was 98.1% and 97.5%, respectively. Overall, 3.5% of patients discontinued therapy. No differences in efficacy, adherence, and persistence were found between alirocumab and evolocumab. Conclusions: PCSK9i are safe and effective in clinical practice, leading to very high adherence and persistence to therapy, and achievement of recommended LDL-C target in most patients, especially when used as combination therapy.
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- 2023
4. PB0124 Treatment with PCSK9 Inhibitors in Patients with Familial Hypercholesterolemia Lowers Plasma Levels of Platelet Activating Factor and its Precursors: A Combined Metabolomic and Lipidomic Approach
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Calcaterra, I., primary, Di Minno, A., additional, Orsini, R., additional, Chiesa, M., additional, Cavalca, V., additional, Tripaldella, M., additional, Anesi, A., additional, Fiorelli, S., additional, Eligini, S., additional, Palermo, V., additional, Donnarumma, S., additional, Tufano, A., additional, Iannuzzo, G., additional, Colombo, G., additional, Tremoli, E., additional, Porro, B., additional, and Di Minno, M., additional
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- 2023
- Full Text
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5. Volanesorsen to treat severe hypertriglyceridemia: A pooled analysis of randomized controlled trials
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Calcaterra, I.L., primary, Lupoli, R., additional, Di Minno, A., additional, Pontoriero, M.T., additional, Palermo, V., additional, Donnarumma, S., additional, Di Cola, N. Schiano, additional, Iannuzzo, G., additional, and Di Minno, M.N.D., additional
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- 2023
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6. Long-term efficacy and safety of lomitapide in patients with familial chylomicronemia syndrome (FCS): Data from the LOCHNES study
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Giammanco, A., primary, Cefalù, A., additional, D'Erasmo, L., additional, Iannuzzo, G., additional, Noto, D., additional, Montali, A., additional, Zambon, A., additional, Forte, F., additional, Suppressa, P., additional, Giannini, S., additional, Barbagallo, C.M., additional, Ganci, A., additional, Nardi, E., additional, Brancatelli, G., additional, Caldarella, R., additional, Ciaccio, M., additional, Arca, M., additional, and Averna, M., additional
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- 2023
- Full Text
- View/download PDF
7. The Role of Registers in Increasing Knowledge and Improving Management of Children and Adolescents Affected by Familial Hypercholesterolemia: the LIPIGEN Pediatric Group
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Gazzotti, M, Casula, M, Bertolini, S, Capra, M, Olmastroni, E, Catapano, A, Pederiva, C, Allevi, M, Arca, M, Auricchio, R, Averna, M, Baldera, D, Banderali, G, Bartuli, A, Biasucci, G, Borghi, C, Bruzzi, P, Buganza, R, Buonuomo, P, Calabro, P, Calandra, S, Carubbi, F, Cesaro, A, Cipollone, F, Citroni, N, Covetti, G, Cremonini, A, D'Addato, S, Ben, M, Di Taranto, M, Fortunato, G, Franceschi, R, Galimberti, F, Genovesi, S, Giammanco, A, Grigore, L, Guardamagna, O, Iannuzzi, A, Iannuzzo, G, Lascala, L, Locatelli, F, Iughetti, L, Madaghiele, S, Mandraffino, G, Mannarino, M, Marco, B, Maroni, L, Minicocci, I, Mombelli, G, Muntoni, S, Nascimbeni, F, Parati, G, Passaro, A, Pavanello, C, Pellegatta, F, Perla, F, Generale, M, Pirro, M, Pisciotta, L, Pujia, A, Purrello, F, Rinaldi, E, Sarzani, R, Scicali, R, Suppressa, P, Tarugi, P, Verachtert, S, Vigna, G, Werba, J, Zambon, A, Zambon, S, Zenti, M, Gazzotti M., Casula M., Bertolini S., Capra M. E., Olmastroni E., Catapano A. L., Pederiva C., Allevi M., Arca M., Auricchio R., Averna M., Baldera D., Banderali G., Bartuli A., Biasucci G., Borghi C., Bruzzi P., Buganza R., Buonuomo P. S., Calabro P., Calandra S., Carubbi F., Cesaro A., Cipollone F., Citroni N., Covetti G., Cremonini A., D'Addato S., Ben M. D., Di Taranto M. D., Fortunato G., Franceschi R., Galimberti F., Genovesi S., Giammanco A., Grigore L., Guardamagna O., Iannuzzi A., Iannuzzo G., Lascala L., Locatelli F., Iughetti L., Madaghiele S., Mandraffino G., Mannarino M. R., Marco B., Maroni L., Minicocci I., Mombelli G., Muntoni S., Nascimbeni F., Parati G., Passaro A., Pavanello C., Pellegatta F., Perla F. M., Generale M., Pirro M., Pisciotta L., Pujia A., Purrello F., Rinaldi E., Sarzani R., Scicali R., Suppressa P., Tarugi P., Verachtert S., Vigna G. B., Werba J. P., Zambon A., Zambon S., Zenti M. G., Gazzotti, M, Casula, M, Bertolini, S, Capra, M, Olmastroni, E, Catapano, A, Pederiva, C, Allevi, M, Arca, M, Auricchio, R, Averna, M, Baldera, D, Banderali, G, Bartuli, A, Biasucci, G, Borghi, C, Bruzzi, P, Buganza, R, Buonuomo, P, Calabro, P, Calandra, S, Carubbi, F, Cesaro, A, Cipollone, F, Citroni, N, Covetti, G, Cremonini, A, D'Addato, S, Ben, M, Di Taranto, M, Fortunato, G, Franceschi, R, Galimberti, F, Genovesi, S, Giammanco, A, Grigore, L, Guardamagna, O, Iannuzzi, A, Iannuzzo, G, Lascala, L, Locatelli, F, Iughetti, L, Madaghiele, S, Mandraffino, G, Mannarino, M, Marco, B, Maroni, L, Minicocci, I, Mombelli, G, Muntoni, S, Nascimbeni, F, Parati, G, Passaro, A, Pavanello, C, Pellegatta, F, Perla, F, Generale, M, Pirro, M, Pisciotta, L, Pujia, A, Purrello, F, Rinaldi, E, Sarzani, R, Scicali, R, Suppressa, P, Tarugi, P, Verachtert, S, Vigna, G, Werba, J, Zambon, A, Zambon, S, Zenti, M, Gazzotti M., Casula M., Bertolini S., Capra M. E., Olmastroni E., Catapano A. L., Pederiva C., Allevi M., Arca M., Auricchio R., Averna M., Baldera D., Banderali G., Bartuli A., Biasucci G., Borghi C., Bruzzi P., Buganza R., Buonuomo P. S., Calabro P., Calandra S., Carubbi F., Cesaro A., Cipollone F., Citroni N., Covetti G., Cremonini A., D'Addato S., Ben M. D., Di Taranto M. D., Fortunato G., Franceschi R., Galimberti F., Genovesi S., Giammanco A., Grigore L., Guardamagna O., Iannuzzi A., Iannuzzo G., Lascala L., Locatelli F., Iughetti L., Madaghiele S., Mandraffino G., Mannarino M. R., Marco B., Maroni L., Minicocci I., Mombelli G., Muntoni S., Nascimbeni F., Parati G., Passaro A., Pavanello C., Pellegatta F., Perla F. M., Generale M., Pirro M., Pisciotta L., Pujia A., Purrello F., Rinaldi E., Sarzani R., Scicali R., Suppressa P., Tarugi P., Verachtert S., Vigna G. B., Werba J. P., Zambon A., Zambon S., and Zenti M. G.
- Abstract
Pathology registers can be a useful tool to overcome obstacles in the identification and management of familial hypercholesterolemia since childhood. In 2018, the LIPIGEN pediatric group was constituted within the Italian LIPIGEN study to focus on FH subjects under 18 years. This work aimed at discussing its recent progress and early outcomes. Demographic, biochemical, and genetic baseline characteristics were collected, with an in-depth analysis of the genetic defects. The analysis was carried out on 1,602 children and adolescents (mean age at baseline 9.9 ± 4.0 years), and almost the whole cohort underwent the genetic test (93.3%). Overall, the untreated mean value of LDL-C was 220.0 ± 97.2 mg/dl, with an increasing gradient from subjects with a negative (N = 317; mean untreated LDL-C = 159.9 ± 47.7 mg/dl), inconclusive (N = 125; mean untreated LDL-C = 166.4 ± 56.5 mg/dl), or positive (N = 1,053; mean untreated LDL-C = 246.5 ± 102.1 mg/dl) genetic diagnosis of FH. In the latter group, the LDL-C values presented a great variability based on the number and the biological impact of involved causative variants. The LIPIGEN pediatric group represents one of the largest cohorts of children with FH, allowing the deepening of the characterization of their baseline and genetic features, providing the basis for further longitudinal investigations for complete details.
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- 2022
8. Clinical Approach in the Management of Paediatric Patients with Familial Hypercholesterolemia: A National Survey Conducted by the LIPIGEN Paediatric Group
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Pederiva, C, Gazzotti, M, Arca, M, Averna, M, Banderali, G, Biasucci, G, Brambilla, M, Buonuomo, P, Calabrò, P, Cipollone, F, Citroni, N, D'Addato, S, Del Ben, M, Genovesi, S, Guardamagna, O, Iannuzzo, G, Iughetti, L, Mandraffino, G, Maroni, L, Mombelli, G, Muntoni, S, Nascimbeni, F, Passaro, A, Pellegatta, F, Pirro, M, Pisciotta, L, Pujia, R, Sarzani, R, Scicali, R, Suppressa, P, Zambon, S, Zenti, M, Calandra, S, Catapano, A, Tarugi, P, Galimberti, F, Casula, M, Capra, M, Pederiva, Cristina, Gazzotti, Marta, Arca, Marcello, Averna, Maurizio, Banderali, Giuseppe, Biasucci, Giacomo, Brambilla, Marta, Buonuomo, Paola Sabrina, Calabrò, Paolo, Cipollone, Francesco, Citroni, Nadia, D'Addato, Sergio, Del Ben, Maria, Genovesi, Simonetta, Guardamagna, Ornella, Iannuzzo, Gabriella, Iughetti, Lorenzo, Mandraffino, Giuseppe, Maroni, Lorenzo, Mombelli, Giuliana, Muntoni, Sandro, Nascimbeni, Fabio, Passaro, Angelina, Pellegatta, Fabio, Pirro, Matteo, Pisciotta, Livia, Pujia, Roberta, Sarzani, Riccardo, Scicali, Roberto, Suppressa, Patrizia, Zambon, Sabina, Zenti, Maria Grazia, Calandra, Sebastiano, Catapano, Alberico Luigi, Tarugi, Patrizia, Galimberti, Federica, Casula, Manuela, Capra, Maria Elena, Pederiva, C, Gazzotti, M, Arca, M, Averna, M, Banderali, G, Biasucci, G, Brambilla, M, Buonuomo, P, Calabrò, P, Cipollone, F, Citroni, N, D'Addato, S, Del Ben, M, Genovesi, S, Guardamagna, O, Iannuzzo, G, Iughetti, L, Mandraffino, G, Maroni, L, Mombelli, G, Muntoni, S, Nascimbeni, F, Passaro, A, Pellegatta, F, Pirro, M, Pisciotta, L, Pujia, R, Sarzani, R, Scicali, R, Suppressa, P, Zambon, S, Zenti, M, Calandra, S, Catapano, A, Tarugi, P, Galimberti, F, Casula, M, Capra, M, Pederiva, Cristina, Gazzotti, Marta, Arca, Marcello, Averna, Maurizio, Banderali, Giuseppe, Biasucci, Giacomo, Brambilla, Marta, Buonuomo, Paola Sabrina, Calabrò, Paolo, Cipollone, Francesco, Citroni, Nadia, D'Addato, Sergio, Del Ben, Maria, Genovesi, Simonetta, Guardamagna, Ornella, Iannuzzo, Gabriella, Iughetti, Lorenzo, Mandraffino, Giuseppe, Maroni, Lorenzo, Mombelli, Giuliana, Muntoni, Sandro, Nascimbeni, Fabio, Passaro, Angelina, Pellegatta, Fabio, Pirro, Matteo, Pisciotta, Livia, Pujia, Roberta, Sarzani, Riccardo, Scicali, Roberto, Suppressa, Patrizia, Zambon, Sabina, Zenti, Maria Grazia, Calandra, Sebastiano, Catapano, Alberico Luigi, Tarugi, Patrizia, Galimberti, Federica, Casula, Manuela, and Capra, Maria Elena
- Abstract
Detection and treatment of patients with familial hypercholesterolemia (FH) starting from childhood is fundamental to reduce morbidity and mortality. The activity of National realities such as the LIPIGEN (LIpid transPort disorders Italian GEnetic Network) Paediatric Group, founded in 2018, is a milestone in this context. The aim of this exploratory survey, conducted in October 2021 among Italian lipid clinics included in the LIPIGEN Paediatric Group, was to investigate the current clinical approach in the management and treatment of paediatric patients with suspected FH. A digital questionnaire composed of 20 questions investigating nutritional treatment and nutraceutical and pharmacological therapy for children and adolescents with FH was proposed to the principal investigators of 30 LIPIGEN centres. Twenty-four centres responded to the section referring to children aged < 10 years and 30 to that referring to adolescents. Overall, 66.7% of children and 73.3% of adolescents were given lipid-lowering nutritional treatment as the first intervention level for at least 3–4 months (29.2% and 23.3%) or 6–12 months (58.3% and 53.3%). Nutraceuticals were considered in 41.7% (regarding children) and 50.0% (regarding adolescents) of the centres as a supplementary approach to diet. Lipid-lowering drug therapy initiation was mainly recommended (91.7% and 80.0%). In 83.3% of children and 96.7% of adolescents, statins were the most frequently prescribed drug. We highlighted several differences in the treatment of paediatric patients with suspected FH among Italian centres; however, the overall approach is in line with the European Atherosclerosis Society (EAS) recommendations for FH children and adolescents. We consider this survey as a starting point to reinforce collaboration between LIPIGEN centres and to elaborate in the near future a consensus document on the management of paediatric patients with suspected FH so as to improve and uniform detection, management, and treat
- Published
- 2023
9. Management of intracranial hypertension following traumatic brain injury: a best clinical practice adoption proposal for intracranial pressure monitoring and decompressive craniectomy. Joint statements by the Traumatic Brain Injury Section of the Italian Society of Neurosurgery (SINch) and the Neuroanesthesia and Neurocritical Care Study Group of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI)
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Iaccarino C., Lippa L., Munari M., Castioni C. A., Robba C., Caricato A., Pompucci A., Signoretti S., Zona G., Rasulo F. A., Aimar E., Amato S., Angileri F. F., Anile C., Assietti R., Baratto V., Barbanera A., Basile L., Battaglia R., Bellocchi S., Bertuccio A., Blanco S., Bolognini A., Boniferro B., Bordi L., Bortolotti C., Brandini V., Broger M., Brollo M., Caffarella D. D., Caggiano C., Cantisani P. L., Capone C., Cappelletto B., Capuano C., Carangelo B., Caruselli G., Chessa M. A., Chiara M., Chibbaro S., Cioffi V., Ciprianocecchi P., Colistra D., Conti C., Contratti F., Costella G. B., Cuoci A., D'Avella D., D'Ercole M., Deangelis M., Defalco R., de Luca G., de Marinis P., Del Vecchio C., Delfinis C., Denaro L., Deodato F., Desogus N., Disomma A., Domenicucci M., Dones F., Fina M., Fiori L., Fricia M., Gaetani P., Gazzeri R., Gentile M., Germano A., Ghadirpour R., Gianfreda C. D., Gigante N., Gigli R., Giorgetti J., Giusa M., Gravina U. G., Grippi L., Guida F., Guizzardi G., Iannuzzo G., Kropp M., Lattanzi L., Lucantoni D., Maffei L., Magliulo M., Marconi F., Marruzzo D., Martellotta N., Marton E., Maugeri R., Mauro G., Meli F., Menniti A., Merciadri P., Milanese L., Nardacci B., Nasi D., Orvieto P., Pacca P., Pansini G., Panzarasa G., Passanisi M., Pavesi G., Pizzoni C., Pulera F., Rapana A., Ricci A., Rispoli R., Rotondo M., Russo N., Santilli S., Scarano E., Schwarz A., Servadei F., Simonetti G., Stefini R., Talamonti G., Turrisi A., Valente V. M., Villa A., Vindigni M., Visocchi M., Vitali M., Wierzbicki V., Zambon G., Zanotti B., Zenga F., Alampi D., Alessandri F., Aloj F., Amigoni A., Aspide R., Bertuetti R., Betti V., Bilotta F., Bonato V., Bosco E., Brita M., Buscema G., Cafiero T., Cappuccio D., Caradonna M., Caria C. G., Casartelliliviero M., Ciritella P., Cirrincione S., Citerio G., Colelli S., Coletta F., Concordia L., Congedo E., Covotta M., Crimella F., Dall'Acqua G., De Cassai A., Defulviis S., Deperi E., Deana C., Delgaudio A., Denittis N., Dicolandrea S., Divezza F., Ferri F., Flocco R., Fontana C., Forastierimolinari A., Frangiosa A., Fumagalli P., Fuselli E., Garbarino M. M., Gelormini D., Geraci C., Geraldini F., Giacomucci A., Giampaoli V., Giorgetti D., Gritti P., Gualdani S., Iacovazzo C., Iermano C., Latronico N., Lugari S., Lusenti F., Maglione C., Magnoni S., Maiarota F., Malla M., Marchesi M., Martino C., Matteotti I., Mazzeo A. T., Morello G., Nardiello I., Paticchio F., Pegoli M., Perotti V., Piazzolla M., Picciafuochi F., Rachedi N., Radolovich D. K., Recchia A., Riccardi S., Romagnoli S., Sala S., Scafuro M. A., Sgarlata P., Soragni A., Stefani F., Stival E., Stofella G., Terranova F., Tinturini R., Togni T., Toto R., Trapani D., Tringali E., Tullo L., Valente A., Valeo T., Varelli G., Villani R., Zamacavicchi F., Zanello M., Zarrillo N., Zugni N., Iaccarino, C, Lippa, L, Munari, M, Castioni, C, Robba, C, Caricato, A, Pompucci, A, Signoretti, S, Zona, G, Rasulo, F, Aimar, E, Amato, S, Angileri, F, Anile, C, Assietti, R, Baratto, V, Barbanera, A, Basile, L, Battaglia, R, Bellocchi, S, Bertuccio, A, Blanco, S, Bolognini, A, Boniferro, B, Bordi, L, Bortolotti, C, Brandini, V, Broger, M, Brollo, M, Caffarella, D, Caggiano, C, Cantisani, P, Capone, C, Cappelletto, B, Capuano, C, Carangelo, B, Caruselli, G, Chessa, M, Chiara, M, Chibbaro, S, Cioffi, V, Ciprianocecchi, P, Colistra, D, Conti, C, Contratti, F, Costella, G, Cuoci, A, D'Avella, D, D'Ercole, M, Deangelis, M, Defalco, R, de Luca, G, de Marinis, P, Del Vecchio, C, Delfinis, C, Denaro, L, Deodato, F, Desogus, N, Disomma, A, Domenicucci, M, Dones, F, Fina, M, Fiori, L, Fricia, M, Gaetani, P, Gazzeri, R, Gentile, M, Germano, A, Ghadirpour, R, Gianfreda, C, Gigante, N, Gigli, R, Giorgetti, J, Giusa, M, Gravina, U, Grippi, L, Guida, F, Guizzardi, G, Iannuzzo, G, Kropp, M, Lattanzi, L, Lucantoni, D, Maffei, L, Magliulo, M, Marconi, F, Marruzzo, D, Martellotta, N, Marton, E, Maugeri, R, Mauro, G, Meli, F, Menniti, A, Merciadri, P, Milanese, L, Nardacci, B, Nasi, D, Orvieto, P, Pacca, P, Pansini, G, Panzarasa, G, Passanisi, M, Pavesi, G, Pizzoni, C, Pulera, F, Rapana, A, Ricci, A, Rispoli, R, Rotondo, M, Russo, N, Santilli, S, Scarano, E, Schwarz, A, Servadei, F, Simonetti, G, Stefini, R, Talamonti, G, Turrisi, A, Valente, V, Villa, A, Vindigni, M, Visocchi, M, Vitali, M, Wierzbicki, V, Zambon, G, Zanotti, B, Zenga, F, Alampi, D, Alessandri, F, Aloj, F, Amigoni, A, Aspide, R, Bertuetti, R, Betti, V, Bilotta, F, Bonato, V, Bosco, E, Brita, M, Buscema, G, Cafiero, T, Cappuccio, D, Caradonna, M, Caria, C, Casartelliliviero, M, Ciritella, P, Cirrincione, S, Citerio, G, Colelli, S, Coletta, F, Concordia, L, Congedo, E, Covotta, M, Crimella, F, Dall'Acqua, G, De Cassai, A, Defulviis, S, Deperi, E, Deana, C, Delgaudio, A, Denittis, N, Dicolandrea, S, Divezza, F, Ferri, F, Flocco, R, Fontana, C, Forastierimolinari, A, Frangiosa, A, Fumagalli, P, Fuselli, E, Garbarino, M, Gelormini, D, Geraci, C, Geraldini, F, Giacomucci, A, Giampaoli, V, Giorgetti, D, Gritti, P, Gualdani, S, Iacovazzo, C, Iermano, C, Latronico, N, Lugari, S, Lusenti, F, Maglione, C, Magnoni, S, Maiarota, F, Malla, M, Marchesi, M, Martino, C, Matteotti, I, Mazzeo, A, Morello, G, Nardiello, I, Paticchio, F, Pegoli, M, Perotti, V, Piazzolla, M, Picciafuochi, F, Rachedi, N, Radolovich, D, Recchia, A, Riccardi, S, Romagnoli, S, Sala, S, Scafuro, M, Sgarlata, P, Soragni, A, Stefani, F, Stival, E, Stofella, G, Terranova, F, Tinturini, R, Togni, T, Toto, R, Trapani, D, Tringali, E, Tullo, L, Valente, A, Valeo, T, Varelli, G, Villani, R, Zamacavicchi, F, Zanello, M, Zarrillo, N, Zugni, N, Iaccarino, C., Lippa, L., Munari, M., Castioni, C. A., Robba, C., Caricato, A., Pompucci, A., Signoretti, S., Zona, G., Rasulo, F. A., Aimar, E., Amato, S., Angileri, F. F., Anile, C., Assietti, R., Baratto, V., Barbanera, A., Basile, L., Battaglia, R., Bellocchi, S., Bertuccio, A., Blanco, S., Bolognini, A., Boniferro, B., Bordi, L., Bortolotti, C., Brandini, V., Broger, M., Brollo, M., Caffarella, D. D., Caggiano, C., Cantisani, P. L., Capone, C., Cappelletto, B., Capuano, C., Carangelo, B., Caruselli, G., Chessa, M. A., Chiara, M., Chibbaro, S., Cioffi, V., Ciprianocecchi, P., Colistra, D., Conti, C., Contratti, F., Costella, G. B., Cuoci, A., D'Avella, D., D'Ercole, M., Deangelis, M., Defalco, R., de Luca, G., de Marinis, P., Del Vecchio, C., Delfinis, C., Denaro, L., Deodato, F., Desogus, N., Disomma, A., Domenicucci, M., Dones, F., Fina, M., Fiori, L., Fricia, M., Gaetani, P., Gazzeri, R., Gentile, M., Germano, A., Ghadirpour, R., Gianfreda, C. D., Gigante, N., Gigli, R., Giorgetti, J., Giusa, M., Gravina, U. G., Grippi, L., Guida, F., Guizzardi, G., Iannuzzo, G., Kropp, M., Lattanzi, L., Lucantoni, D., Maffei, L., Magliulo, M., Marconi, F., Marruzzo, D., Martellotta, N., Marton, E., Maugeri, R., Mauro, G., Meli, F., Menniti, A., Merciadri, P., Milanese, L., Nardacci, B., Nasi, D., Orvieto, P., Pacca, P., Pansini, G., Panzarasa, G., Passanisi, M., Pavesi, G., Pizzoni, C., Pulera, F., Rapana, A., Ricci, A., Rispoli, R., Rotondo, M., Russo, N., Santilli, S., Scarano, E., Schwarz, A., Servadei, F., Simonetti, G., Stefini, R., Talamonti, G., Turrisi, A., Valente, V. M., Villa, A., Vindigni, M., Visocchi, M., Vitali, M., Wierzbicki, V., Zambon, G., Zanotti, B., Zenga, F., Alampi, D., Alessandri, F., Aloj, F., Amigoni, A., Aspide, R., Bertuetti, R., Betti, V., Bilotta, F., Bonato, V., Bosco, E., Brita, M., Buscema, G., Cafiero, T., Cappuccio, D., Caradonna, M., Caria, C. G., Casartelliliviero, M., Ciritella, P., Cirrincione, S., Citerio, G., Colelli, S., Coletta, F., Concordia, L., Congedo, E., Covotta, M., Crimella, F., Dall'Acqua, G., De Cassai, A., Defulviis, S., Deperi, E., Deana, C., Delgaudio, A., Denittis, N., Dicolandrea, S., Divezza, F., Ferri, F., Flocco, R., Fontana, C., Forastierimolinari, A., Frangiosa, A., Fumagalli, P., Fuselli, E., Garbarino, M. M., Gelormini, D., Geraci, C., Geraldini, F., Giacomucci, A., Giampaoli, V., Giorgetti, D., Gritti, P., Gualdani, S., Iacovazzo, C., Iermano, C., Latronico, N., Lugari, S., Lusenti, F., Maglione, C., Magnoni, S., Maiarota, F., Malla, M., Marchesi, M., Martino, C., Matteotti, I., Mazzeo, A. T., Morello, G., Nardiello, I., Paticchio, F., Pegoli, M., Perotti, V., Piazzolla, M., Picciafuochi, F., Rachedi, N., Radolovich, D. K., Recchia, A., Riccardi, S., Romagnoli, S., Sala, S., Scafuro, M. A., Sgarlata, P., Soragni, A., Stefani, F., Stival, E., Stofella, G., Terranova, F., Tinturini, R., Togni, T., Toto, R., Trapani, D., Tringali, E., Tullo, L., Valente, A., Valeo, T., Varelli, G., Villani, R., Zamacavicchi, F., Zanello, M., Zarrillo, N., and Zugni, N.
- Subjects
medicine.medical_specialty ,Decompressive Craniectomy ,Consensus development conference ,Decompressive craniectomy ,Guideline ,Traumatic brain injuries ,Critical Care ,Intracranial Pressure ,medicine.medical_treatment ,MEDLINE ,Neurosurgery ,Traumatic brain injurie ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Intensive care ,Settore MED/41 - ANESTESIOLOGIA ,Brain Injuries, Traumatic ,medicine ,Humans ,Anesthesia ,Intensive care medicine ,Randomized Controlled Trials as Topic ,business.industry ,Neurointensive care ,Evidence-based medicine ,Italy ,030220 oncology & carcinogenesis ,Intracranial pressure monitoring ,Surgery ,Neurology (clinical) ,Analgesia ,Intracranial Hypertension ,business ,030217 neurology & neurosurgery ,Human - Abstract
No robust evidence is provided by literature regarding the management of intracranial hypertension following severe traumatic brain injury (TBI). This is mostly due to the lack of prospective randomized controlled trials (RCTs), the presence of studies containing extreme heterogeneously collected populations and controversial considerations about chosen outcome. A scientific society should provide guidelines for care management and scientific support for those areas for which evidence-based medicine has not been identified. However, RCTs in severe TBI have failed to establish intervention effectiveness, arising the need to make greater use of tools such as Consensus Conferences between experts, which have the advantage of providing recommendations based on experience, on the analysis of updated literature data and on the direct comparison of different logistic realities. The Italian scientific societies should provide guidelines following the national laws ruling the best medical practice. However, many limitations do not allow the collection of data supporting high levels of evidence for intracranial pressure (ICP) monitoring and decompressive craniectomy (DC) in patients with severe TBI. This intersociety document proposes best practice guidelines for this subsetting of patients to be adopted on a national Italian level, along with joint statements from "TBI Section" of the Italian Society of Neurosurgery (SINch) endorsed by the Neuroanesthesia and Neurocritical Care Study Group of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI). Presented here is a recap of recommendations on management of ICP and DC supported a high level of available evidence and rate of agreement expressed by the assemblies during the more recent consensus conferences, where members of both groups have had a role of active participants and supporters. The listed recommendations have been sent to a panel of experts consisting of the 107 members of the "TBI Section" of the SINch and the 111 members of the Neuroanesthesia and Neurocritical Care Study Group of the SIAARTI. The aim of the survey was to test a preliminary evaluation of the grade of predictable future adherence of the recommendations following this intersociety proposal. The following recommendations are suggested as representing best clinical practice, nevertheless, adoption of local multidisciplinary protocols regarding thresholds of ICP values, drug therapies, hemostasis management and perioperative care of decompressed patients is strongly recommended to improve treatment efficiency, to increase the quality of data collection and to provide more powerful evidence with future studies. Thus, for this future perspective a rapid overview of the role of the multimodal neuromonitoring in the optimal severe TBI management is also provided in this document. It is reasonable to assume that the recommendations reported in this paper will in future be updated by new observations arising from future trials. They are not binding, and this document should be offered as a guidance for clinical practice through an intersociety agreement, taking in consideration the low level of evidence.
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- 2021
10. PCSK9 inhibitors: effectiveness of treatment and changes in background lipid-lowering therapy in a real world Italian population. The AT-TARGET-IT study
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Perrone-Filardi, P, primary, Basile, C, additional, Asile, G, additional, Abbate, C, additional, Catalano, A, additional, Merlini, P A, additional, Calabro', P, additional, Iannuzzo, G, additional, Ciccone, M M, additional, Paloscia, L, additional, Varbella, F, additional, Brunetti, N D, additional, Indolfi, C, additional, Paolillo, S, additional, and Gargiulo, P, additional
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- 2022
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11. Lomitapide effectively reduces triglyceride (TG) levels in familial chylomicronemia syndrome (FCS)
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Cefalù, A.B., primary, D'Erasmo, L., additional, Giammanco, A., additional, Montali, A., additional, Iannuzzo, G., additional, Zambon, A., additional, Forte, F., additional, Noto, D., additional, Suppressa, P., additional, Giannini, S., additional, Arca, M., additional, and Averna, M., additional
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- 2022
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12. Evidence of novel APO B gene complex allele causing familial hypercholesterolaemia
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Palma, D., primary, Cardiero, G., additional, Flagiello, C., additional, Galicia-Garcia, U., additional, Larrea, A., additional, Di Taranto, M.D., additional, Martin, C., additional, Iannuzzo, G., additional, Di Minno, M.N.D., additional, Pipolo, A., additional, and Fortunato, G., additional
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- 2022
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13. A novel missense variant in CREB3L3 gene associated with severe hypertriglyceridemia
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Cardiero, G., primary, Palma, D., additional, Di Taranto, M.D., additional, Esposito, M.V., additional, Iannuzzo, G., additional, Di Minno, M.N.D., additional, Molino, C., additional, Iannuzzi, A., additional, and Fortunato, G., additional
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- 2022
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14. Management of intracranial hypertension following traumatic brain injury: A best clinical practice adoption proposal for intracranial pressure monitoring and decompressive craniectomy: Joint statements by the Traumatic Brain Injury Section of the Italian Society of Neurosurgery (SINch) and the Neuroanesthesia and Neurocritical Care Study Group of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI)
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Iaccarino, C, Lippa, L, Munari, M, Castioni, C, Robba, C, Caricato, A, Pompucci, A, Signoretti, S, Zona, G, Rasulo, F, Aimar, E, Amato, S, Angileri, F, Anile, C, Assietti, R, Baratto, V, Barbanera, A, Basile, L, Battaglia, R, Bellocchi, S, Bertuccio, A, Blanco, S, Bolognini, A, Boniferro, B, Bordi, L, Bortolotti, C, Brandini, V, Broger, M, Brollo, M, Caffarella, D, Caggiano, C, Cantisani, P, Capone, C, Cappelletto, B, Capuano, C, Carangelo, B, Caruselli, G, Chessa, M, Chiara, M, Chibbaro, S, Cioffi, V, Ciprianocecchi, P, Colistra, D, Conti, C, Contratti, F, Costella, G, Cuoci, A, D'Avella, D, D'Ercole, M, Deangelis, M, Defalco, R, de Luca, G, de Marinis, P, Del Vecchio, C, Delfinis, C, Denaro, L, Deodato, F, Desogus, N, Disomma, A, Domenicucci, M, Dones, F, Fina, M, Fiori, L, Fricia, M, Gaetani, P, Gazzeri, R, Gentile, M, Germano, A, Ghadirpour, R, Gianfreda, C, Gigante, N, Gigli, R, Giorgetti, J, Giusa, M, Gravina, U, Grippi, L, Guida, F, Guizzardi, G, Iannuzzo, G, Kropp, M, Lattanzi, L, Lucantoni, D, Maffei, L, Magliulo, M, Marconi, F, Marruzzo, D, Martellotta, N, Marton, E, Maugeri, R, Mauro, G, Meli, F, Menniti, A, Merciadri, P, Milanese, L, Nardacci, B, Nasi, D, Orvieto, P, Pacca, P, Pansini, G, Panzarasa, G, Passanisi, M, Pavesi, G, Pizzoni, C, Pulera, F, Rapana, A, Ricci, A, Rispoli, R, Rotondo, M, Russo, N, Santilli, S, Scarano, E, Schwarz, A, Servadei, F, Simonetti, G, Stefini, R, Talamonti, G, Turrisi, A, Valente, V, Villa, A, Vindigni, M, Visocchi, M, Vitali, M, Wierzbicki, V, Zambon, G, Zanotti, B, Zenga, F, Alampi, D, Alessandri, F, Aloj, F, Amigoni, A, Aspide, R, Bertuetti, R, Betti, V, Bilotta, F, Bonato, V, Bosco, E, Brita, M, Buscema, G, Cafiero, T, Cappuccio, D, Caradonna, M, Caria, C, Casartelliliviero, M, Ciritella, P, Cirrincione, S, Citerio, G, Colelli, S, Coletta, F, Concordia, L, Congedo, E, Covotta, M, Crimella, F, Dall'Acqua, G, De Cassai, A, Defulviis, S, Deperi, E, Deana, C, Delgaudio, A, Denittis, N, Dicolandrea, S, Divezza, F, Ferri, F, Flocco, R, Fontana, C, Forastierimolinari, A, Frangiosa, A, Fumagalli, P, Fuselli, E, Garbarino, M, Gelormini, D, Geraci, C, Geraldini, F, Giacomucci, A, Giampaoli, V, Giorgetti, D, Gritti, P, Gualdani, S, Iacovazzo, C, Iermano, C, Latronico, N, Lugari, S, Lusenti, F, Maglione, C, Magnoni, S, Maiarota, F, Malla, M, Marchesi, M, Martino, C, Matteotti, I, Mazzeo, A, Morello, G, Nardiello, I, Paticchio, F, Pegoli, M, Perotti, V, Piazzolla, M, Picciafuochi, F, Rachedi, N, Radolovich, D, Recchia, A, Riccardi, S, Romagnoli, S, Sala, S, Scafuro, M, Sgarlata, P, Soragni, A, Stefani, F, Stival, E, Stofella, G, Terranova, F, Tinturini, R, Togni, T, Toto, R, Trapani, D, Tringali, E, Tullo, L, Valente, A, Valeo, T, Varelli, G, Villani, R, Zamacavicchi, F, Zanello, M, Zarrillo, N, Zugni, N, Iaccarino C., Lippa L., Munari M., Castioni C. A., Robba C., Caricato A., Pompucci A., Signoretti S., Zona G., Rasulo F. A., Aimar E., Amato S., Angileri F. F., Anile C., Assietti R., Baratto V., Barbanera A., Basile L., Battaglia R., Bellocchi S., Bertuccio A., Blanco S., Bolognini A., Boniferro B., Bordi L., Bortolotti C., Brandini V., Broger M., Brollo M., Caffarella D. D., Caggiano C., Cantisani P. L., Capone C., Cappelletto B., Capuano C., Carangelo B., Caruselli G., Chessa M. A., Chiara M., Chibbaro S., Cioffi V., Ciprianocecchi P., Colistra D., Conti C., Contratti F., Costella G. B., Cuoci A., D'Avella D., D'Ercole M., Deangelis M., Defalco R., de Luca G., de Marinis P., Del Vecchio C., Delfinis C., Denaro L., Deodato F., Desogus N., Disomma A., Domenicucci M., Dones F., Fina M., Fiori L., Fricia M., Gaetani P., Gazzeri R., Gentile M., Germano A., Ghadirpour R., Gianfreda C. D., Gigante N., Gigli R., Giorgetti J., Giusa M., Gravina U. G., Grippi L., Guida F., Guizzardi G., Iannuzzo G., Kropp M., Lattanzi L., Lucantoni D., Maffei L., Magliulo M., Marconi F., Marruzzo D., Martellotta N., Marton E., Maugeri R., Mauro G., Meli F., Menniti A., Merciadri P., Milanese L., Nardacci B., Nasi D., Orvieto P., Pacca P., Pansini G., Panzarasa G., Passanisi M., Pavesi G., Pizzoni C., Pulera F., Rapana A., Ricci A., Rispoli R., Rotondo M., Russo N., Santilli S., Scarano E., Schwarz A., Servadei F., Simonetti G., Stefini R., Talamonti G., Turrisi A., Valente V. M., Villa A., Vindigni M., Visocchi M., Vitali M., Wierzbicki V., Zambon G., Zanotti B., Zenga F., Alampi D., Alessandri F., Aloj F., Amigoni A., Aspide R., Bertuetti R., Betti V., Bilotta F., Bonato V., Bosco E., Brita M., Buscema G., Cafiero T., Cappuccio D., Caradonna M., Caria C. G., Casartelliliviero M., Ciritella P., Cirrincione S., Citerio G., Colelli S., Coletta F., Concordia L., Congedo E., Covotta M., Crimella F., Dall'Acqua G., De Cassai A., Defulviis S., Deperi E., Deana C., Delgaudio A., Denittis N., Dicolandrea S., Divezza F., Ferri F., Flocco R., Fontana C., Forastierimolinari A., Frangiosa A., Fumagalli P., Fuselli E., Garbarino M. M., Gelormini D., Geraci C., Geraldini F., Giacomucci A., Giampaoli V., Giorgetti D., Gritti P., Gualdani S., Iacovazzo C., Iermano C., Latronico N., Lugari S., Lusenti F., Maglione C., Magnoni S., Maiarota F., Malla M., Marchesi M., Martino C., Matteotti I., Mazzeo A. T., Morello G., Nardiello I., Paticchio F., Pegoli M., Perotti V., Piazzolla M., Picciafuochi F., Rachedi N., Radolovich D. K., Recchia A., Riccardi S., Romagnoli S., Sala S., Scafuro M. A., Sgarlata P., Soragni A., Stefani F., Stival E., Stofella G., Terranova F., Tinturini R., Togni T., Toto R., Trapani D., Tringali E., Tullo L., Valente A., Valeo T., Varelli G., Villani R., Zamacavicchi F., Zanello M., Zarrillo N., Zugni N., Iaccarino, C, Lippa, L, Munari, M, Castioni, C, Robba, C, Caricato, A, Pompucci, A, Signoretti, S, Zona, G, Rasulo, F, Aimar, E, Amato, S, Angileri, F, Anile, C, Assietti, R, Baratto, V, Barbanera, A, Basile, L, Battaglia, R, Bellocchi, S, Bertuccio, A, Blanco, S, Bolognini, A, Boniferro, B, Bordi, L, Bortolotti, C, Brandini, V, Broger, M, Brollo, M, Caffarella, D, Caggiano, C, Cantisani, P, Capone, C, Cappelletto, B, Capuano, C, Carangelo, B, Caruselli, G, Chessa, M, Chiara, M, Chibbaro, S, Cioffi, V, Ciprianocecchi, P, Colistra, D, Conti, C, Contratti, F, Costella, G, Cuoci, A, D'Avella, D, D'Ercole, M, Deangelis, M, Defalco, R, de Luca, G, de Marinis, P, Del Vecchio, C, Delfinis, C, Denaro, L, Deodato, F, Desogus, N, Disomma, A, Domenicucci, M, Dones, F, Fina, M, Fiori, L, Fricia, M, Gaetani, P, Gazzeri, R, Gentile, M, Germano, A, Ghadirpour, R, Gianfreda, C, Gigante, N, Gigli, R, Giorgetti, J, Giusa, M, Gravina, U, Grippi, L, Guida, F, Guizzardi, G, Iannuzzo, G, Kropp, M, Lattanzi, L, Lucantoni, D, Maffei, L, Magliulo, M, Marconi, F, Marruzzo, D, Martellotta, N, Marton, E, Maugeri, R, Mauro, G, Meli, F, Menniti, A, Merciadri, P, Milanese, L, Nardacci, B, Nasi, D, Orvieto, P, Pacca, P, Pansini, G, Panzarasa, G, Passanisi, M, Pavesi, G, Pizzoni, C, Pulera, F, Rapana, A, Ricci, A, Rispoli, R, Rotondo, M, Russo, N, Santilli, S, Scarano, E, Schwarz, A, Servadei, F, Simonetti, G, Stefini, R, Talamonti, G, Turrisi, A, Valente, V, Villa, A, Vindigni, M, Visocchi, M, Vitali, M, Wierzbicki, V, Zambon, G, Zanotti, B, Zenga, F, Alampi, D, Alessandri, F, Aloj, F, Amigoni, A, Aspide, R, Bertuetti, R, Betti, V, Bilotta, F, Bonato, V, Bosco, E, Brita, M, Buscema, G, Cafiero, T, Cappuccio, D, Caradonna, M, Caria, C, Casartelliliviero, M, Ciritella, P, Cirrincione, S, Citerio, G, Colelli, S, Coletta, F, Concordia, L, Congedo, E, Covotta, M, Crimella, F, Dall'Acqua, G, De Cassai, A, Defulviis, S, Deperi, E, Deana, C, Delgaudio, A, Denittis, N, Dicolandrea, S, Divezza, F, Ferri, F, Flocco, R, Fontana, C, Forastierimolinari, A, Frangiosa, A, Fumagalli, P, Fuselli, E, Garbarino, M, Gelormini, D, Geraci, C, Geraldini, F, Giacomucci, A, Giampaoli, V, Giorgetti, D, Gritti, P, Gualdani, S, Iacovazzo, C, Iermano, C, Latronico, N, Lugari, S, Lusenti, F, Maglione, C, Magnoni, S, Maiarota, F, Malla, M, Marchesi, M, Martino, C, Matteotti, I, Mazzeo, A, Morello, G, Nardiello, I, Paticchio, F, Pegoli, M, Perotti, V, Piazzolla, M, Picciafuochi, F, Rachedi, N, Radolovich, D, Recchia, A, Riccardi, S, Romagnoli, S, Sala, S, Scafuro, M, Sgarlata, P, Soragni, A, Stefani, F, Stival, E, Stofella, G, Terranova, F, Tinturini, R, Togni, T, Toto, R, Trapani, D, Tringali, E, Tullo, L, Valente, A, Valeo, T, Varelli, G, Villani, R, Zamacavicchi, F, Zanello, M, Zarrillo, N, Zugni, N, Iaccarino C., Lippa L., Munari M., Castioni C. A., Robba C., Caricato A., Pompucci A., Signoretti S., Zona G., Rasulo F. A., Aimar E., Amato S., Angileri F. F., Anile C., Assietti R., Baratto V., Barbanera A., Basile L., Battaglia R., Bellocchi S., Bertuccio A., Blanco S., Bolognini A., Boniferro B., Bordi L., Bortolotti C., Brandini V., Broger M., Brollo M., Caffarella D. D., Caggiano C., Cantisani P. L., Capone C., Cappelletto B., Capuano C., Carangelo B., Caruselli G., Chessa M. A., Chiara M., Chibbaro S., Cioffi V., Ciprianocecchi P., Colistra D., Conti C., Contratti F., Costella G. B., Cuoci A., D'Avella D., D'Ercole M., Deangelis M., Defalco R., de Luca G., de Marinis P., Del Vecchio C., Delfinis C., Denaro L., Deodato F., Desogus N., Disomma A., Domenicucci M., Dones F., Fina M., Fiori L., Fricia M., Gaetani P., Gazzeri R., Gentile M., Germano A., Ghadirpour R., Gianfreda C. D., Gigante N., Gigli R., Giorgetti J., Giusa M., Gravina U. G., Grippi L., Guida F., Guizzardi G., Iannuzzo G., Kropp M., Lattanzi L., Lucantoni D., Maffei L., Magliulo M., Marconi F., Marruzzo D., Martellotta N., Marton E., Maugeri R., Mauro G., Meli F., Menniti A., Merciadri P., Milanese L., Nardacci B., Nasi D., Orvieto P., Pacca P., Pansini G., Panzarasa G., Passanisi M., Pavesi G., Pizzoni C., Pulera F., Rapana A., Ricci A., Rispoli R., Rotondo M., Russo N., Santilli S., Scarano E., Schwarz A., Servadei F., Simonetti G., Stefini R., Talamonti G., Turrisi A., Valente V. M., Villa A., Vindigni M., Visocchi M., Vitali M., Wierzbicki V., Zambon G., Zanotti B., Zenga F., Alampi D., Alessandri F., Aloj F., Amigoni A., Aspide R., Bertuetti R., Betti V., Bilotta F., Bonato V., Bosco E., Brita M., Buscema G., Cafiero T., Cappuccio D., Caradonna M., Caria C. G., Casartelliliviero M., Ciritella P., Cirrincione S., Citerio G., Colelli S., Coletta F., Concordia L., Congedo E., Covotta M., Crimella F., Dall'Acqua G., De Cassai A., Defulviis S., Deperi E., Deana C., Delgaudio A., Denittis N., Dicolandrea S., Divezza F., Ferri F., Flocco R., Fontana C., Forastierimolinari A., Frangiosa A., Fumagalli P., Fuselli E., Garbarino M. M., Gelormini D., Geraci C., Geraldini F., Giacomucci A., Giampaoli V., Giorgetti D., Gritti P., Gualdani S., Iacovazzo C., Iermano C., Latronico N., Lugari S., Lusenti F., Maglione C., Magnoni S., Maiarota F., Malla M., Marchesi M., Martino C., Matteotti I., Mazzeo A. T., Morello G., Nardiello I., Paticchio F., Pegoli M., Perotti V., Piazzolla M., Picciafuochi F., Rachedi N., Radolovich D. K., Recchia A., Riccardi S., Romagnoli S., Sala S., Scafuro M. A., Sgarlata P., Soragni A., Stefani F., Stival E., Stofella G., Terranova F., Tinturini R., Togni T., Toto R., Trapani D., Tringali E., Tullo L., Valente A., Valeo T., Varelli G., Villani R., Zamacavicchi F., Zanello M., Zarrillo N., and Zugni N.
- Abstract
No robust evidence is provided by literature regarding the management of intracranial hypertension following severe traumatic brain injury (TBI). This is mostly due to the lack of prospective randomized controlled trials (RCTs), the presence of studies containing extreme heterogeneously collected populations and controversial considerations about chosen outcome. A scientific society should provide guidelines for care management and scientific support for those areas for which evidence-based medicine has not been identified. However, RCTs in severe TBI have failed to establish intervention effectiveness, arising the need to make greater use of tools such as Consensus Conferences between experts, which have the advantage of providing recommendations based on experience, on the analysis of updated literature data and on the direct comparison of different logistic realities. The Italian scientific societies should provide guidelines following the national laws ruling the best medical practice. However, many limitations do not allow the collection of data supporting high levels of evidence for intracranial pressure (ICP) monitoring and decompressive craniectomy (DC) in patients with severe TBI. This intersociety document proposes best practice guidelines for this subsetting of patients to be adopted on a national Italian level, along with joint statements from “TBI Section” of the Italian Society of Neurosurgery (SINch) endorsed by the Neuroanesthesia and Neurocritical Care Study Group of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI). Presented here is a recap of recommendations on management of ICP and DC supported a high level of available evidence and rate of agreement expressed by the assemblies during the more recent consensus conferences, where members of both groups have had a role of active participants and supporters. The listed recommendations have been sent to a panel of experts consisting of the 107 members of the “T
- Published
- 2021
15. New Ultrasound Technologies for Ischemic Heart Disease Assessment and Monitoring in Cardiac Rehabilitation
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D'Andrea A., Sperlongano S., Pacileo M., Venturini E., Iannuzzo G., Gentile M., Sperlongano R., Vitale G., Maglione M., Cice G., Maria Sarullo, Di Lorenzo, A. Vigorito, Giallauria F., Picano, E., D'Andrea, A., Sperlongano, S., Pacileo, M., Venturini, E., Iannuzzo, G., Gentile, M., Sperlongano, R., Vitale, G., Maglione, M., Cice, G., Maria, Sarullo, Lorenzo, Di, A., Vigorito, Giallauria, F., amp, Picano, E., D'Andrea, Antonello, Sperlongano, Simona, Pacileo, Mario, Venturini, Elio, Iannuzzo, Gabriella, Gentile, Marco, Sperlongano, Rossella, Vitale, Giuseppe, Maglione, Marco, Cice, Gennaro, Maria Sarullo, Filippo, Di Lorenzo, Anna, Vigorito, Carlo, Giallauria, Francesco, and Picano, Eugenio
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Cardiac function curve ,medicine.medical_specialty ,medicine.medical_treatment ,lcsh:Medicine ,Review ,Disease ,030204 cardiovascular system & hematology ,tissue Doppler imaging (TDI) ,ventricular vortex ,03 medical and health sciences ,global longitudinal strain (GLS) ,0302 clinical medicine ,ischemic heart disease (IHD), speckle tracking echocardiography (STE), global longitudinal strain (GLS), left atrial strain, tissue Doppler imaging (TDI), ventricular vortex, color Doppler flow mapping (CDFM), coronary flow reserve (CFR), arterial stiffness, cardiac rehabilitation ,arterial stiffne ,medicine ,030212 general & internal medicine ,Intensive care medicine ,speckle tracking echocardiography (STE) ,Modality (human–computer interaction) ,Modalities ,Rehabilitation ,left atrial strain ,business.industry ,Ultrasound ,lcsh:R ,color Doppler flow mapping (CDFM) ,General Medicine ,medicine.disease ,cardiac rehabilitation ,arterial stiffness ,coronary flow reserve (CFR) ,Arterial stiffness ,ischemic heart disease (IHD) ,business ,Ischemic heart - Abstract
Owing to its ease of application, noninvasive nature, and safety, echocardiography is an essential imaging modality to assess cardiac function in patients affected by ischemic heart disease (IHD). Over the past few decades, we have witnessed a continuous series of evolutions in the ultrasound field that have led to the introduction of innovative echocardiographic modalities which allowed to better understand the morphofunctional abnormalities occurring in cardiovascular diseases. This article offers an overview of some of the newest echocardiographic modalities and their promising application in IHD diagnosis, risk stratification, management, and monitoring after cardiac rehabilitation.
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- 2020
16. EVOLOCUMAB IS EFFECTIVE AND SAFE TO TREAT HYPERCHOLESTEROLEMIA IN A PATIENT WITH STATIN-INDUCED NECROTIZING MYOPATHY
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Calcaterra I, TRIPALDELLA, MARIA, Gentile m, Iannuzzo G, Forte F, BUONAIUTO, ALESSIO, Rubba PO, Di Minno M. N. D, Calcaterra I, Tripaldella M, Gentile M, Iannuzzo G, Forte F, Buonaiuto A, Rubba PO, Di Minno M.N.D, Calcaterra, I, Tripaldella, Maria, Gentile, M, Iannuzzo, G, Forte, F, Buonaiuto, Alessio, Rubba, Po, and Di Minno M. N., D
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evolocumab , hypercholesterolemia,myopaty - Published
- 2019
17. SMALL DENSE LDL IN RELATION TO CHANGES IN OXIDATION MARKERS AND VASCULAR REACTIVITYIN PATIENTS WITH HYPERCHOLESTEROLEMIA TREATED WITH EVOLOCUMAB: A PROSPECTIVE COHORT STUDY
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Calcaterra I, Tripaldella M, Gentile M, Iannuzzo G, Di Taranto MD, Di Minno A., Rubba PO, Di Minno M. N. D, Calcaterra I, Tripaldella M, Gentile M, Iannuzzo G, Di Taranto MD, Di Minno A., Rubba PO, Di Minno M.N.D, Calcaterra, I, Tripaldella, M, Gentile, M, Iannuzzo, G, DI TARANTO, MARIA DONATA, Di Minno, A., Rubba, Po, and Di Minno M. N., D
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- 2019
18. Association between Very Low-Density Lipoprotein Cholesterol (VLDL-C) and Carotid Intima-Media Thickness in Postmenopausal Women Without Overt Cardiovascular Disease and on LDL-C Target Levels
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Gentile M, Iannuzzi A, Giallauria F, D'Andrea A, Venturini E, Pacileo M, Covetti G, Panico C, Mattiello A, Vitale G, Sarullo FM, Rubba P, Vigorito C, Panico S, Iannuzzo G., Gentile, M, Iannuzzi, A, Giallauria, F, D'Andrea, A, Venturini, E, Pacileo, M, Covetti, G, Panico, C, Mattiello, A, Vitale, G, Sarullo, Fm, Rubba, P, Vigorito, C, Panico, S, and Iannuzzo, G.
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VLDL, atherosclerosis, carotid intima-media thickness, women, menopause - Abstract
Background: atherosclerotic process inexorably advances in patients reaching low-density lipoprotein cholesterol (LDL-C) targets. An attractive hypothesis is that lipoprotein particles (very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL)), could contribute to residual risk. The present study aims to investigate the relationship between carotid intima-media thickness (IMT) and different lipoprotein subfractions in a cohort of healthy postmenopausal women. Methods: 75 postmenopausal women, at LDL-C target levels without overt cardiovascular disease, underwent biochemical analyses (including subfraction assay of plasma lipoproteins) and carotid ultrasound examination. Results: a statistically significant correlation between VLDL and carotid IMT (p < 0.001) was found. No significant correlation was found between carotid IMT and LDL-C (p = 0.179), IDL-C (p = 0.815), high-density lipoprotein (HDL) (p = 0.855), and LDL score (p = 0.240). Moreover, IMT is significantly correlated to LDL particle diameter (p = 0.044). After adjusting for age, systolic blood pressure, body mass index, smoking habits, glucose plasma concentration, and Lipoprotein(a) (Lpa) levels, multivariate analysis showed that women in the third tertile of VLDL-C, compared with those in the first tertile, were significantly associated to the highest IMT (p = 0.04). Conclusions: in this cohort of postmenopausal women, VLDL-C was significantly associated to carotid IMT, independent of main cardiovascular risk factors. These findings pave the way for targeting circulating concentrations of VLDL-C to reduce cardiovascular events in patients with target LDL-C levels.
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- 2020
19. A wide next-generation-sequencing panel improves the molecular diagnosis of dyslipidemias
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Giacobbe C., Di Taranto M. D., Palma D., Maione G., Cardiero G., Iannuzzo G., Buonaiuto A., Forte F., Calcaterra I., Fortunato G., Giacobbe, C., Di Taranto, M. D., Palma, D., Maione, G., Cardiero, G., Iannuzzo, G., Buonaiuto, A., Forte, F., Calcaterra, I., and Fortunato, G.
- Abstract
Introduction: Dyslipidemias are common clinical conditions associated to cardiovascular diseases. Among these, Familial Hypercholesterolemia (FH) and severe Hypertriglyceridemia (sHTG) are the most frequent ones. The aim of this study is to evaluate the possible use of a wide next-generation-sequencing (NGS) panel of 28 genes involved in lipid metabolism, to improve the molecular diagnosis of dyslipidemias. Methods: A reanalysis of 25 patients (21 FH and 4 sHTG) previously analyzed for a few causative genes has been carried on. Patients bearing different types of variants [single nucleotide variants (SNVs) and copy number variations (CNVs)] in different genes, previously analyzed with Sanger sequencing and multiplex ligation-dependent probe amplification (MLPA) have been selected. DNA libraries have been prepared using Agilent SureSelect target enrichment protocol; the sequencing has been performed using Illumina MiSeq (V2 150x2 Micro). The results of the sequencing have been evaluated by Agilent SureCall and Agilent Alissa Align & Call and Intrepret pipelines. Results: All previously identified SNVs and CNVs have been confirmed by NGS. Additional rare variants, not always associated with dyslipidemias, were found in 23/25 patients. An additional pathogenic variant in the APOB gene has been identified in a sHTG patient carrying only 1 pathogenic variant in the APOA5 gene (causative of sHTG). Conclusions: The NGS-method confirmed all the results obtained with direct sequencing and MLPA methodologies. Additional rare variants were detected, even if most of them turned out to be variant of uncertain significance (VUS). In conclusion, this NGS approach may enhance the molecular diagnosis of different types of dyslipidemias, thereby leading to a better understanding and detection of complex phenotypes.
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- 2020
20. In vitro characterization revealed five new potential pathogenic variants in the APOB gene
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Di Taranto, M.D., primary, Galicia, U., additional, Larrea, A., additional, Giacobbe, C., additional, Calcaterra, I., additional, Palma, D., additional, Cardiero, G., additional, Iannuzzo, G., additional, Di Minno, M.N.D., additional, Iannuzzi, A., additional, Martín, C., additional, and Fortunato, G., additional
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- 2021
- Full Text
- View/download PDF
21. Management of intracranial hypertension following traumatic brain injury: A best clinical practice adoption proposal for intracranial pressure monitoring and decompressive craniectomy: Joint statements by the Traumatic Brain Injury Section of the Italian Society of Neurosurgery (SINch) and the Neuroanesthesia and Neurocritical Care Study Group of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI)
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Iaccarino, C., Lippa, L., Munari, M., Castioni, C. A., Robba, C., Caricato, Anselmo, Pompucci, Angelo, Signoretti, S., Zona, G., Rasulo, F. A., Aimar, E., Amato, S., Angileri, F. F., Anile, Carmelo, Assietti, R., Baratto, V., Barbanera, A., Basile, L., Battaglia, R., Bellocchi, S., Bertuccio, A., Blanco, S., Bolognini, A., Boniferro, B., Bordi, L., Bortolotti, C., Brandini, V., Broger, Maximilian, Brollo, M., Caffarella, D. D., Caggiano, Cinzia, Cantisani, P. L., Capone, C., Cappelletto, B., Capuano, C., Carangelo, B., Caruselli, G., Chessa, M. A., Chiara, M., Chibbaro, S., Cioffi, V., Ciprianocecchi, P., Colistra, D., Conti, C., Contratti, F., Costella, G. B., Cuoci, A., D'Avella, D., D'Ercole, Manuela, Deangelis, M., Defalco, R., de Luca, G., de Marinis, P., Del Vecchio, C., Delfinis, C., Denaro, Luca, Deodato, F., Desogus, N., Disomma, A., Domenicucci, M., Dones, F., Fina, M., Fiori, L., Fricia, M., Gaetani, P., Gazzeri, R., Gentile, M., Germano, A., Ghadirpour, R., Gianfreda, C. D., Gigante, N., Gigli, R., Giorgetti, J., Giusa, M., Gravina, U. G., Grippi, L., Guida, F., Guizzardi, G., Iannuzzo, G., Kropp, M., Lattanzi, L., Lucantoni, D., Maffei, L., Magliulo, M., Marconi, F., Marruzzo, D., Martellotta, N., Marton, E., Maugeri, R., Mauro, G., Meli, F., Menniti, A., Merciadri, P., Milanese, L., Nardacci, B., Nasi, D., Orvieto, P., Pacca, P., Pansini, G., Panzarasa, G., Passanisi, M., Pavesi, G., Pizzoni, C., Pulera, F., Rapana, A., Ricci, A., Rispoli, R., Rotondo, M., Russo, N., Santilli, S., Scarano, E., Schwarz, A., Servadei, Franco, Simonetti, G., Stefini, R., Talamonti, G., Turrisi, A., Valente, V. M., Villa, A., Vindigni, M., Visocchi, Massimiliano, Vitali, M., Wierzbicki, V., Zambon, G., Zanotti, B., Zenga, F., Alampi, D., Alessandri, F., Aloj, F., Amigoni, A., Aspide, R., Bertuetti, R., Betti, V., Bilotta, F., Bonato, V., Bosco, E., Brita, M., Buscema, G., Cafiero, T., Cappuccio, D., Caradonna, M., Caria, C. G., Casartelliliviero, M., Ciritella, P., Cirrincione, S., Citerio, G., Colelli, S., Coletta, F., Concordia, L., Congedo, E., Covotta, M., Crimella, F., Dall'Acqua, G., De Cassai, A., Defulviis, S., Deperi, E., Deana, C., Delgaudio, A., Denittis, N., Dicolandrea, S., Divezza, F., Ferri, F., Flocco, R., Fontana, C., Forastierimolinari, A., Frangiosa, A., Fumagalli, P., Fuselli, E., Garbarino, M. M., Gelormini, D., Geraci, C., Geraldini, F., Giacomucci, A., Giampaoli, V., Giorgetti, D., Gritti, P., Gualdani, S., Iacovazzo, C., Iermano, C., Latronico, N., Lugari, S., Lusenti, F., Maglione, C., Magnoni, S., Maiarota, F., Malla, M., Marchesi, M., Martino, C., Matteotti, I., Mazzeo, A. T., Morello, G., Nardiello, I., Paticchio, F., Pegoli, M., Perotti, Valerio, Piazzolla, M., Picciafuochi, F., Rachedi, N., Radolovich, D. K., Recchia, A., Riccardi, S., Romagnoli, S., Sala, S., Scafuro, M. A., Sgarlata, P., Soragni, A., Stefani, F., Stival, Eleonora, Stofella, G., Terranova, F., Tinturini, R., Togni, T., Toto, R., Trapani, D., Tringali, E., Tullo, L., Valente, A., Valeo, T., Varelli, G., Villani, R., Zamacavicchi, F., Zanello, M., Zarrillo, N., Zugni, N., Caricato A. (ORCID:0000-0001-5929-120X), Pompucci A. (ORCID:0000-0002-5427-9719), Anile C. (ORCID:0000-0002-0481-9713), Broger M., Caggiano C., D'Ercole M., Denaro L., Servadei F., Visocchi M. (ORCID:0000-0003-1087-0491), Perotti V. (ORCID:0000-0001-9461-2101), Stival E., Iaccarino, C., Lippa, L., Munari, M., Castioni, C. A., Robba, C., Caricato, Anselmo, Pompucci, Angelo, Signoretti, S., Zona, G., Rasulo, F. A., Aimar, E., Amato, S., Angileri, F. F., Anile, Carmelo, Assietti, R., Baratto, V., Barbanera, A., Basile, L., Battaglia, R., Bellocchi, S., Bertuccio, A., Blanco, S., Bolognini, A., Boniferro, B., Bordi, L., Bortolotti, C., Brandini, V., Broger, Maximilian, Brollo, M., Caffarella, D. D., Caggiano, Cinzia, Cantisani, P. L., Capone, C., Cappelletto, B., Capuano, C., Carangelo, B., Caruselli, G., Chessa, M. A., Chiara, M., Chibbaro, S., Cioffi, V., Ciprianocecchi, P., Colistra, D., Conti, C., Contratti, F., Costella, G. B., Cuoci, A., D'Avella, D., D'Ercole, Manuela, Deangelis, M., Defalco, R., de Luca, G., de Marinis, P., Del Vecchio, C., Delfinis, C., Denaro, Luca, Deodato, F., Desogus, N., Disomma, A., Domenicucci, M., Dones, F., Fina, M., Fiori, L., Fricia, M., Gaetani, P., Gazzeri, R., Gentile, M., Germano, A., Ghadirpour, R., Gianfreda, C. D., Gigante, N., Gigli, R., Giorgetti, J., Giusa, M., Gravina, U. G., Grippi, L., Guida, F., Guizzardi, G., Iannuzzo, G., Kropp, M., Lattanzi, L., Lucantoni, D., Maffei, L., Magliulo, M., Marconi, F., Marruzzo, D., Martellotta, N., Marton, E., Maugeri, R., Mauro, G., Meli, F., Menniti, A., Merciadri, P., Milanese, L., Nardacci, B., Nasi, D., Orvieto, P., Pacca, P., Pansini, G., Panzarasa, G., Passanisi, M., Pavesi, G., Pizzoni, C., Pulera, F., Rapana, A., Ricci, A., Rispoli, R., Rotondo, M., Russo, N., Santilli, S., Scarano, E., Schwarz, A., Servadei, Franco, Simonetti, G., Stefini, R., Talamonti, G., Turrisi, A., Valente, V. M., Villa, A., Vindigni, M., Visocchi, Massimiliano, Vitali, M., Wierzbicki, V., Zambon, G., Zanotti, B., Zenga, F., Alampi, D., Alessandri, F., Aloj, F., Amigoni, A., Aspide, R., Bertuetti, R., Betti, V., Bilotta, F., Bonato, V., Bosco, E., Brita, M., Buscema, G., Cafiero, T., Cappuccio, D., Caradonna, M., Caria, C. G., Casartelliliviero, M., Ciritella, P., Cirrincione, S., Citerio, G., Colelli, S., Coletta, F., Concordia, L., Congedo, E., Covotta, M., Crimella, F., Dall'Acqua, G., De Cassai, A., Defulviis, S., Deperi, E., Deana, C., Delgaudio, A., Denittis, N., Dicolandrea, S., Divezza, F., Ferri, F., Flocco, R., Fontana, C., Forastierimolinari, A., Frangiosa, A., Fumagalli, P., Fuselli, E., Garbarino, M. M., Gelormini, D., Geraci, C., Geraldini, F., Giacomucci, A., Giampaoli, V., Giorgetti, D., Gritti, P., Gualdani, S., Iacovazzo, C., Iermano, C., Latronico, N., Lugari, S., Lusenti, F., Maglione, C., Magnoni, S., Maiarota, F., Malla, M., Marchesi, M., Martino, C., Matteotti, I., Mazzeo, A. T., Morello, G., Nardiello, I., Paticchio, F., Pegoli, M., Perotti, Valerio, Piazzolla, M., Picciafuochi, F., Rachedi, N., Radolovich, D. K., Recchia, A., Riccardi, S., Romagnoli, S., Sala, S., Scafuro, M. A., Sgarlata, P., Soragni, A., Stefani, F., Stival, Eleonora, Stofella, G., Terranova, F., Tinturini, R., Togni, T., Toto, R., Trapani, D., Tringali, E., Tullo, L., Valente, A., Valeo, T., Varelli, G., Villani, R., Zamacavicchi, F., Zanello, M., Zarrillo, N., Zugni, N., Caricato A. (ORCID:0000-0001-5929-120X), Pompucci A. (ORCID:0000-0002-5427-9719), Anile C. (ORCID:0000-0002-0481-9713), Broger M., Caggiano C., D'Ercole M., Denaro L., Servadei F., Visocchi M. (ORCID:0000-0003-1087-0491), Perotti V. (ORCID:0000-0001-9461-2101), and Stival E.
- Abstract
No robust evidence is provided by literature regarding the management of intracranial hypertension following severe traumatic brain injury (TBI). This is mostly due to the lack of prospective randomized controlled trials (RCTs), the presence of studies containing extreme heterogeneously collected populations and controversial considerations about chosen outcome. A scientific society should provide guidelines for care management and scientific support for those areas for which evidence-based medicine has not been identified. However, RCTs in severe TBI have failed to establish intervention effectiveness, arising the need to make greater use of tools such as Consensus Conferences between experts, which have the advantage of providing recommendations based on experience, on the analysis of updated literature data and on the direct comparison of different logistic realities. The Italian scientific societies should provide guidelines following the national laws ruling the best medical practice. However, many limitations do not allow the collection of data supporting high levels of evidence for intracranial pressure (ICP) monitoring and decompressive craniectomy (DC) in patients with severe TBI. This intersociety document proposes best practice guidelines for this subsetting of patients to be adopted on a national Italian level, along with joint statements from “TBI Section” of the Italian Society of Neurosurgery (SINch) endorsed by the Neuroanesthesia and Neurocritical Care Study Group of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI). Presented here is a recap of recommendations on management of ICP and DC supported a high level of available evidence and rate of agreement expressed by the assemblies during the more recent consensus conferences, where members of both groups have had a role of active participants and supporters. The listed recommendations have been sent to a panel of experts consisting of the 107 members of the “T
- Published
- 2021
22. Carotid artery wall hypertrophy in children with metabolic syndrome
- Author
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Iannuzzi, A, Licenziati, M R, Acampora, C, De Michele, M, Iannuzzo, G, Chiariello, G, Covetti, G, Bresciani, A, Romano, L, Panico, S, and Rubba, P
- Published
- 2008
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23. Association between atherogenic index of plasma and carotid intima-media thickness in a cohort of Mediterranean women
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Gentile, M., primary, Iannuzzo, G., additional, Simeon, V., additional, Mattiello, A., additional, Rubba, F., additional, Panico, C., additional, Panico, S., additional, and Rubba, P., additional
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- 2020
- Full Text
- View/download PDF
24. Correlation between different LDL-R mutations and response to AB-PCSK9 therapy in a group of patient with genetic diagnosis of familial hypercholesterolemia
- Author
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Buonaiuto, A., primary, Gentile, M., additional, Calcaterra, I., additional, Giacobbe, C., additional, Tripaldella, M., additional, Forte, F., additional, Di Minno, M.N.D., additional, Iannuzzo, G., additional, Fortunato, G., additional, and Rubba, P., additional
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- 2020
- Full Text
- View/download PDF
25. Spectrum of genetic variants in patients suffering from familial chylomicronaemia syndrome and multifactorial chylomicronaemia syndrome
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Giacobbe, C., primary, Di Taranto, M.D., additional, Palma, D., additional, Maione, G., additional, Cardiero, G., additional, Forte, F., additional, Iannuzzo, G., additional, Rubba, P., additional, and Fortunato, G., additional
- Published
- 2020
- Full Text
- View/download PDF
26. Genetics and biochemical profile of patients with homozygous familial hypercholesterolemia
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Di Taranto, M.D., primary, Giacobbe, C., additional, Buonaiuto, A., additional, Calcaterra, I., additional, Palma, D., additional, Maione, G., additional, Cardiero, G., additional, Iannuzzo, G., additional, Di Minno, M.N.D., additional, Rubba, P., additional, and Fortunato, G., additional
- Published
- 2020
- Full Text
- View/download PDF
27. Changes in carotid stiffness in patients with familial hypercholesterolemia treated with evolocumab®: A prospective cohort study
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Calcaterra, I., primary, Gentile, M., additional, Iannuzzo, G., additional, Tripaldella, M., additional, Di Minno, A., additional, Forte, F., additional, Buonaiuto, A., additional, Di Taranto, M.D., additional, Rubba, P., additional, and Di Minno, M.N.D., additional
- Published
- 2020
- Full Text
- View/download PDF
28. Changes in markers of subclinical atherosclerosis in patients with familial hypercholesterolemia treated with evolocumab: a prospective cohort study
- Author
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Calcaterra, I, primary, Di Minno, A, additional, Gentile, M, additional, Tripaldella, M, additional, Buonaiuto, A, additional, Forte, F, additional, Di Taranto, M.D, additional, Giacobbe, C, additional, Iannuzzo, G, additional, Rubba, P.O.F, additional, and Di Minno, M.N.D, additional
- Published
- 2020
- Full Text
- View/download PDF
29. Correlation between different LDL-R mutations and response to ab-PCSK9 therapy in a group of patient with genetic diagnosis of Familial Hypercholesterolemia. Preliminary report
- Author
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Buonaiuto, A, primary, Gentile, M, additional, Calcaterra, I.L, additional, Giacobbe, C, additional, Tripaldella, M, additional, Forte, F, additional, Iannuzzo, G, additional, Di Minno, M.N.D, additional, Fortunato, G, additional, and Rubba, P.O.F, additional
- Published
- 2020
- Full Text
- View/download PDF
30. Oncology and Cardiac Rehabilitation: An Underrated Relationship
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Venturini, E., primary, Iannuzzo, G., additional, D’Andrea, A., additional, Pacileo, M., additional, Tarantini, L., additional, Canale, M.L., additional, Gentile, M., additional, Vitale, G., additional, Sarullo, F.M., additional, Vastarella, R., additional, Di Lorenzo, A., additional, Testa, C., additional, Parlato, A., additional, Vigorito, C., additional, and Giallauria, F., additional
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- 2020
- Full Text
- View/download PDF
31. Prognostic and Predictive biomarkers in a Mediterranean cohort (Review from Atena Project)
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Rubba, F, primary, Gentile, M, primary, Scamardo, M S, primary, Iannuzzo, G, primary, Panico, C, primary, Pacilio, M, primary, D’Onofrio, G, primary, Panico, S, primary, Rubba, P, primary, and Triassi, M, primary
- Published
- 2019
- Full Text
- View/download PDF
32. Association between atherogenic index of plasma and carotid intima-media thickness in a cohort of Mediterranean women.
- Author
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Gentile, M., Iannuzzo, G., Simeon, V., Mattiello, A., Rubba, F., Panico, C., Panico, S., and Rubba, P.
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- 2021
- Full Text
- View/download PDF
33. Impaired endothelium-dependent vascular reactivity in patients with familial combined hyperlipidaemia
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De Michele, M, Iannuzzi, A, Salvato, A, Pauciullo, P, Gentile, M, Iannuzzo, G, Panico, S, Pujia, A, Bond, G M, and Rubba, P
- Published
- 2007
34. Smart coatings of epoxy based CNTs designed to meet practical expectations in aeronautics
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Vertuccio, L., primary, Guadagno, L., additional, Spinelli, G., additional, Lamberti, P., additional, Zarrelli, M., additional, Russo, S., additional, and Iannuzzo, G., additional
- Published
- 2018
- Full Text
- View/download PDF
35. Effect of carbon nanotube and functionalized liquid rubber on mechanical and electrical properties of epoxy adhesives for aircraft structures
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Vertuccio, L., primary, Guadagno, L., additional, Spinelli, G., additional, Russo, S., additional, and Iannuzzo, G., additional
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- 2017
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- View/download PDF
36. Association between Triglyceride-Rich-Lipoprotein subfractions and carotid atherosclerosis in post-menopausal women
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La Fata, E., primary, Gentile, M., additional, Iannuzzi, A., additional, Covetti, G., additional, D'Elia, L., additional, Iannuzzo, G., additional, Panico, S., additional, and Rubba, P., additional
- Published
- 2017
- Full Text
- View/download PDF
37. Association between Lp (a) and small dense LDL in menopausal women without Metabolic Syndrome
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Tripaldella, M., primary, Gentile, M., additional, Jossa, F., additional, Marotta, G., additional, Iannuzzo, G., additional, Buonaiuto, A., additional, Fata, E.L., additional, Panico, S., additional, Mattiello, A., additional, and Rubba, P., additional
- Published
- 2017
- Full Text
- View/download PDF
38. Resina epossidica multifunzionale con accresciuta resistenza alla fiamma
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Guadagno, Liberata, Raimondo, Marialuigia, Longo, Pasquale, Bonnaud, L., Murariu, O., Dubois, P. h., Russo, S., and Iannuzzo, G.
- Published
- 2015
39. Resina epossidica con basso tenore di umidità
- Author
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Guadagno, Liberata, Iannuzzo, G., Lamberti, Patrizia, Naddeo, Carlo, Raimondo, Marialuigia, Russo, S., Tucci, Vincenzo, and Vittoria, Vittoria
- Published
- 2015
40. Relation of body mass index with carotid intima-media thickness and diameter is independent of metabolic syndrome in postmenopausal Mediterranean women
- Author
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Gentile M, Iannuzzi A, Iannuzzo G, Covetti G, Mattiello A, De Michele M, PANICO, SALVATORE, RUBBA, PAOLO OSVALDO FEDERICO, Gentile, M, Iannuzzi, A, Iannuzzo, G, Covetti, G, Panico, Salvatore, Mattiello, A, De Michele, M, and Rubba, PAOLO OSVALDO FEDERICO
- Published
- 2012
41. Relation of body mass index with intima media thickness and diameters is independent of metabolic syndrome in post menopausal women
- Author
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Gentile M., Iannuzzi A., De Michele M., PANICO, SALVATORE, Mattiello A., Iannuzzo G., La Fata E., Maresca L., Sodano M., Jossa F., RUBBA, PAOLO OSVALDO FEDERICO, Gentile, M., Iannuzzi, A., De Michele, M., Panico, Salvatore, Mattiello, A., Iannuzzo, G., La Fata, E., Maresca, L., Sodano, M., Jossa, F., and Rubba, PAOLO OSVALDO FEDERICO
- Published
- 2010
42. Familial Combined hyperlipidemia and IMT
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Covetti G., Iannuzzi A., Gentile M., Pauciullo P., Iannuzzo G., Marotta G., Bresciani A., PANICO, SALVATORE, RUBBA, PAOLO OSVALDO FEDERICO, Covetti, G., Iannuzzi, A., Gentile, M., Pauciullo, P., Iannuzzo, G., Marotta, G., Bresciani, A., Panico, Salvatore, and Rubba, PAOLO OSVALDO FEDERICO
- Published
- 2009
43. Comparison of two diets of varying glycemic index on carotid subclinical atherosclerosis in obese children
- Author
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Iannuzzi A, Licenziati MR, Vacca M, De Marco D, Cinquegrana G, Laccetti M, Bresciani A, Covetti G, Iannuzzo G, Parillo M., RUBBA, PAOLO OSVALDO FEDERICO, Iannuzzi, A, Licenziati, Mr, Vacca, M, De Marco, D, Cinquegrana, G, Laccetti, M, Bresciani, A, Covetti, G, Iannuzzo, G, Rubba, PAOLO OSVALDO FEDERICO, and Parillo, M.
- Published
- 2009
44. THE RELATIONSHIP BETWEEN ANGER AND SEXUAL BEHAVIOR: A REVIEW OF THEORIES AND RESEARCH
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Iannuzzo, G., Pandolfo, Gianluca, Bonadonna, A., Lorusso, Simona, Crucitti, Manuela, Lanza, Giulia, Cicciarelli, C., and Bruno, Antonio
- Subjects
lcsh:Psychology ,lcsh:BF1-990 - Abstract
The aim of this paper is to explore the state of the art about the connection between anger and sexual behavior in eterosexual couples. After a description of anger in psychiatric and psychological literature, the Authors review the available studies about anger-sexuality relationship from theorethical, clinical and experimental point of view. They conclude that there is, till now, a significant confusion about the question. Therefore, Authors suggest a new approach to this problem, due to the possible relevance of the topic in clinical practice. Despite the complexity of this research area, there is a need of clarification regarding methodological trends and clinical perspectives. Authors suggest the relevance of such a research for the understanding of sexual behavior, sexual couples problems and the finding of treatment strategies for anger problems connected to sexual behavior., Mediterranean Journal of Clinical Psychology, Vol 2, No 1 (2014)
- Published
- 2014
45. Effects of weight modification on hs-crp in a cohort of mediterranean women: findings from progetto atena
- Author
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Gentile M., Mattiello A., Pauciullo P., Jossa F., Marotta G., SANTUCCI DE MAGISTRIS, MARIA, Del Pezzo M., Iannuzzo G., Rubba F., RUBBA, PAOLO OSVALDO FEDERICO, PANICO, SALVATORE, Gentile, M., Mattiello, A., Pauciullo, P., Jossa, F., Marotta, G., SANTUCCI DE MAGISTRIS, Maria, Del Pezzo, M., Iannuzzo, G., Rubba, F., Rubba, PAOLO OSVALDO FEDERICO, and Panico, Salvatore
- Published
- 2008
46. Association between small dense LDL particles and early atherosclerosis in a sample of middle-aged women. Findings from Progetto Atena
- Author
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Gentile M., Iannuzzo G., Ubaldi S., PANICO, SALVATORE, Jossa F., Mattiello A., Marotta G., Pauciullo P., RUBBA, PAOLO OSVALDO FEDERICO, Gentile, M., Iannuzzo, G., Ubaldi, S., Panico, Salvatore, Jossa, F., Mattiello, A., Marotta, G., Pauciullo, P., and Rubba, PAOLO OSVALDO FEDERICO
- Published
- 2008
47. Early carotid atherosclerosis in obesity and overweight is independent of hs-CRP in a cohort of mediterranean women: findings from Progetto Atena
- Author
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Gentile M., Iannuzzo G., PANICO, SALVATORE, Jossa F., Mattiello A., Rubba F., Marotta G., Pauciullo P., RUBBA, PAOLO OSVALDO FEDERICO, Gentile, M., Iannuzzo, G., Panico, Salvatore, Jossa, F., Mattiello, A., Rubba, F., Marotta, G., Pauciullo, P., and Rubba, PAOLO OSVALDO FEDERICO
- Published
- 2008
48. The association between overweight/obesity with early signs of atherosclerosis is independent of insulin resistance (HOMA INDEX) and inflammation (HS-CRP)
- Author
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RUBBA, PAOLO OSVALDO FEDERICO, Gentile M., Iannuzzo G., Mattiello A., De Michele M., PANICO, SALVATORE, Rubba, PAOLO OSVALDO FEDERICO, Gentile, M., Iannuzzo, G., Mattiello, A., De Michele, M., and Panico, Salvatore
- Published
- 2007
49. Association between small dense ldl and cardiovascular events in Familial combined hyperlipidemia
- Author
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Gentile M, Pauciullo P, Ubaldi S, Marotta G, Baiano A, Jossa F, Iannuzzo G, Mormile C, PANICO, SALVATORE, RUBBA, PAOLO OSVALDO FEDERICO, Gentile, M, Pauciullo, P, Ubaldi, S, Marotta, G, Baiano, A, Jossa, F, Iannuzzo, G, Mormile, C, Panico, Salvatore, and Rubba, PAOLO OSVALDO FEDERICO
- Published
- 2007
50. Inflammatory markers in Familial Combined Hyperlipidemia
- Author
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Pauciullo P., Gentile M., Ubaldi S, Marotta G., Jossa F., Iannuzzo G., Faccenda F., RUBBA, PAOLO OSVALDO FEDERICO, Pauciullo, P., Gentile, M., Ubaldi, S, Marotta, G., Jossa, F., Iannuzzo, G., Faccenda, F., and Rubba, PAOLO OSVALDO FEDERICO
- Published
- 2006
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