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152 results on '"Iauk, L"'

2. Antibacterial activity of Propolis and its active principles alone and in combination with macrolides, beta-lactams and fluoroquinolones against microorganisms responsible for respiratory infections

Author

Speciale, A, Costanzo, R, Puglisi, S, Musumeci, R, Catania, M, Caccamo, F, Iauk, L, Catania, MR, Iauk, L., MUSUMECI, ROSARIO, Speciale, A, Costanzo, R, Puglisi, S, Musumeci, R, Catania, M, Caccamo, F, Iauk, L, Catania, MR, Iauk, L., and MUSUMECI, ROSARIO

Abstract

Propolis is produced by bees and is reported to have several pharmaceutical properties. Its antibacterial activity against strains causing upper respiratory tract infections is particularly important: propolis might be used as a therapeutic agent to prevent the bacterial infections that sometimes overlap viral infections. In this study the in vitro activity of both an alcoholic solution and a hydroglyceric extract of propolis, as well as its active principles, was tested against bacteria responsible for respiratory infections (Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis and Streptococcus pyogenes). We also evaluated the in vitro activity of a combination of propolis and its active principles and some beta-lactams, macrolides and fluoroquinolones. Our results, though not demonstrating a clearly synergistic activity between antibiotics and propolis and its constituents, show the possibility of using natural preparations, due to their antimicrobial and anti-inflammatory properties, to enhance antibacterial therapy.

Published
2006

3. Anti mycotic activity of Ruta chalepensis L

Author

Iauk, L, Flores, M, Ragusa, S, Rapisarda, A, Greco, A M, Minardi, R, and Oliveri, S

Subjects
médicament, History & Philosophy Of Science, cutaneous pathologies treatment, dermatophytes, ethanol extract, guérisseur, SCI034000, médecine traditionnelle, Nursing, new assay, plante médicinale, paludisme, SOC057000, JFFH, leishmaniose, ethnopharmacologie, pharmacopée, Antifungal activity, ethnobotanique, PDX
Abstract

Note portant sur l'auteur Note portant sur l'auteur Note portant sur l'auteur Note portant sur l'auteur Note portant sur l'auteur Note portant sur l'auteur Note portant sur l'auteur Introduction Ruta chalapensis L. (Rutaceae), a perennial herb, widely diffused in the Mediterranean area, with glabrous stem, alternate bi-pinnatisect leaves with narrowly oblong-lanceolate or obovate segments, inflorescence cymose, growing in dry, usually rocky areas, is an ancient medicinal plant still used in t...

Published
2014

4. Berberis aetnensis C. Presl. extracts: antimicrobial properties and interaction with ciprofloxacin

Author

Musumeci, R, Speciale, A, Costanzo, R, Annino, A, Ragusa, S, Rapisarda, A, Pappalardo, M, Iauk, L, MUSUMECI, ROSARIO, Pappalardo, MS, Iauk, L., Musumeci, R, Speciale, A, Costanzo, R, Annino, A, Ragusa, S, Rapisarda, A, Pappalardo, M, Iauk, L, MUSUMECI, ROSARIO, Pappalardo, MS, and Iauk, L.

Abstract

Previous research showed that berberine-containing Berberis species synthesise the substances 5'-methoxyhydnocarpin-D (5'-MHC-D) and pheophorbide a, which have no antimicrobial activity but inhibit the expression of multidrug resistant efflux pumps (MDRs) in Staphylococcus aureus and potentiate the action of berberine. The MDR pumps extrude synthetic and natural antimicrobials from bacterial cells. We searched for these compounds in Berberis aetnensis C. Presl. (Berberidaceae), an endemic plant of the volcano Mount Etna. This work confirms the presence of pheophorbide a and permits us to hypothesise the presence of 5'-MHC-D in leaf extracts. In fact, the activity of ciprofloxacin was improved when two chromatographic fractions isolated from leaf extracts were added. These results are indicative of the presence of MDR pump inhibitors. Moreover, crude extracts were tested on several micro-organisms and showed antimicrobial activity mainly against Gram-positive bacteria and yeasts

Published
2003

11. Oxidative profile in patients with colon cancer: effects of Ruta chalepensis L

Author

Acquaviva, Rosaria, Iauk, L, Sorrenti, Valeria, Lanteri, R, Santangelo, R, Licata, A, Licata, F, Vanella, A, Malaguarnera, Mariano, Ragusa, S, and DI GIACOMO, Claudia

Subjects
Adult, Aged, 80 and over, Male, Ruta, Oxidative Stress, Plant Extracts, Colonic Neoplasms, Humans, Female, Middle Aged, Antioxidants, Aged, Phytotherapy
Abstract

To verify the involvement of free radicals in tumor progression and to investigate the effects of an ethanolic extract of Ruta Chalepensis L. and of rutin in blood of patients with colon cancer.Leaves of Ruta Chalepensis L. were collected in the area around Catania (Italy). For the preparation of the ethanol extract of leaves, an exhaustive extraction of 100 g of the drug was carried out in Soxhlet with 800 ml of 95% ethanol. Fifty-six patients with colorectal cancer were randomly selected for this study; among these, 34 were affected by an early stage (T1 N0 M0 according to scale), while 22 were affected by an advanced stage (T4, N1-2, M0) of cancer. Data obtained from these patients were compared with those of a control group consisting of 20 healthy subjects. Plasma of each sample was used for determining non-proteic antioxidant capacity, thiol groups, lipid hydroperoxides and nitrite/nitrate levels, evaluated by spectrophotometric tests. In addition, percentage of haemolysis was evaluated incubating (for 2 hours at 37 degrees C) erythrocyte suspension with a free radical donor (50 mM 2,2'-azobis-amidino propane chloridrate), in the presence or absence of ethanolic extract of Ruta Chalepensis L. (250 microg/ml) or rutin (1 mM).Non-proteic antioxidant capacity was significantly lower in cancerous patients than in healthy subjects (p0.001). This decrease was stage-related. In fact, non-proteic antioxidant capacity resulted lower in advanced than in early colorectal cancer (p0.001). The same significant stage-related decrease was observed in plasma thiol groups (p0.001). Coherently with the decrease in non-proteic antioxidant capacity and thiol groups, higher levels of lipid hydroperoxides and nitrite/nitrate were observed in patients with colorectal cancer with respect to healthy subjects (p0.001) and the increase in these markers of oxidative stress was related to the cancer stadiation. Neoplastic patients also showed an increased percentage of oxidative hemolysis respect to controls and the haemolytic damage was correlated with the stage of colon cancer. Both the extract of Ruta Chalepensis L. and rutin were able to protect erythrocytes from oxidative stress induced by the free radical donor, but the extract of Ruta Chalepensis L. was more effective than rutin. This protective effect was significant only in erythrocytes from patients with early colorectal group, whereas no significant modification was induced by Ruta Chalepensis L. or rutin in red blood cells from advanced colorectal cancer patients exposed to the same experimental conditions.Oxidative stress correlates with colon cancer stadiation and both the extract of Ruta chalepensis and rutin are able to protect red blood cells from radical-induced damage. However, their effects are significant in early stages of cancer. So these natural antioxidants might be usefull to prevent carcinogenesis and/or tumor progression.

Published
2011

39. Des sources du savoir aux médicaments du futur : actes du 4e congrès européen d'ethnopharmacologie = From the sources of knowledge to the medicines of the future = proceedings of the 4th European Congress on Ethnopharmocology

Author

Iauk, L., Flores, M., Ragusa, S., Rapisarda, A., Greco, A.M., Minardi, R., Oliveri, S., Fleurentin, J. (ed.), Pelt, J.M. (ed.), Mazars, G. (ed.), Lejosne, J.C. (trad.), and Cabalion, Pierre (collab.)

Subjects
TRAITEMENT MEDICAL, CULTURE IN VITRO, PLANTE MEDICINALE, EVALUATION, ETUDE COMPARATIVE, ACTIVITE ANTIFONGIQUE, EFFICACITE
Published
2002

42. Des sources du savoir aux médicaments du futur

Author

Aguirre Marco, P C, Ambe, Guy-Alain, Ansay, Michel, Anton, R, Anton, Robert, Aragón, R, Arango, G J, Baerts, Martine, Baghdikian, B, Balagizi, Innocent, Balansard, G, Balansard, Guy, Blancou, Jean, Bouchet, Françoise, Bouchet, Marie-Jeanne, Bourdy, Geneviève, Bravo, J. A., Bravo, José, Burtscher, Doris, Chávez de Michel, L. R., Christoph, H, Chrubasik, Sigrun, Claisse-Dauchy, Renée, Cokelaer, Jean-Baptiste, Croft, K, Cudel, Evelyne, de Foucault, Bernard, De Méo, M, De Pasquale, Rita, Deharo, E, Deharo, E., Dekanosidze, G, Delmée, M, Dewalt, S. J., Djadjo Djipa, Corine, Dorangeon, Elodie, Dumenil, G, Echeverri, J, El-Emam, M, El-Naggar, Wael, Elias, R, El Rhaffari, Loussaine, Enokakuiodo, O, Estrada, A, Eyele Mve Mba, Célestin, Flahaut, Elodie, Fleurentin, Jacques, Fleury, Marie, Flores, M, Fontanel, Didier, Frances, Yves, Fresquet Febrer, J L, Galtier, C, George, S, Gimenez, A, Gimenez, A., Giusti, M E, Grazzini, A, Greco, A M, Hassan, R, Heide, L, Heidenreich, Felicia, Henneberg, Maria, Hounzangbé-Adoté, Sylvie, Huffman, Michael A., Iauk, L, Kalis, Simone, Keita, Arouna, Kemertelidze, E, Lamidi, Maroufath, Lavaud, C, Lehmann, Jean, Lesoeurs, Guy, Li, S M, Lobstein, A, Lopez, A, Lumley, Henry de, Maciuk, Alexandre, Mahiou, V, Malaisse, François, Marculescu, Angela, Mat Jais, M, Mazars, Guy, McCahon, L, Mechler, E, Minardi, R, Montlouis, Josyane, Moretti, Christian, Mori, T, Mshvildadze, V, Müller, Markus, Muñoz, V, Muñoz, V., Navet, Eric, Nicolas, Jean-Pierre, Nze-Ekekang, Lucienne, Olicard, Cécile, Oliveri, S, Olivier, Marc, Ollivier, E, Oueida, Fathi, Pelt, Jean-Marie, Perrin, Michel, Pieri, G, Pieroni, Andréa, Pordié, Laurent, Quenevo, C., Quetin-Ledercq, Joëlle, Ragusa, S, Rapisarda, A, Renault-Miskovsky, Josette, Reynier, Jean-Pierre, Rigouzzo-Weiller, Anne-Laure, Roca, A., Roman, S, Ruchter, M, Saha, B P, Sanogo, Rokia, Sanou, B, Sanou, L, Sauer, Fernand, Sauvain, Michel, Sawaya, Antoine, Schröder, Ekkehard, Sporer, F, Stévigny, Caroline, T. Murugesan Pal, M, Tamas, M, Thouzery, Michel, Tra Bi Fezan, Honora, Trojanowska, Anna, Um, B H, Verpoorte, Robert, Viel, C, Wahrendorf, Marit-Saskia, Wemakor, E, Weniger, B, Weniger, Bernard, Wink, M, Zaid, A., Zakaria, Z, Fleurentin, Jacques, Pelt, Jean-Marie, and Mazars, Guy

Subjects
médicament, History & Philosophy Of Science, guérisseur, SCI034000, médecine traditionnelle, Nursing, plante médicinale, Geography, paludisme, SOC057000, JFFH, leishmaniose, ethnopharmacologie, pharmacopée, ethnobotanique, PDX
Abstract

L'origine des pharmacopées traditionnelles L'élaboration des pharmacopées Les médicaments du XXIe siècle Comment les connaissances des savoirs thérapeutiques se sont-elles transmises au travers des différentes cultures ? Cet ouvrage innovant, qui réunit les travaux présentés au 4e Congrès européen d'ethnopharmacologie, fait remonter à la préhistoire les sources des connaissances thérapeutiques. Si les pharmacopées écrites jalonnent l'histoire des grandes médecines savantes, d'autres modes d'accès à la connaissance semblent exister dans l'univers chamanique des sociétés de tradition orale ainsi que dans la façon dont les animaux malades se soignent par les plantes. L'évaluation des propriétés pharmaco-toxicologiques et chimiques des plantes d'usage traditionnel devrait par ailleurs favoriser le développement futur des médicaments à base de plantes, l'un des thèmes porteurs abordés dans cet ouvrage. Mais l'objectif de ce livre est aussi de susciter, partout dans le monde, de nouvelles thématiques de recherche dans le domaine de la préhistoire du médicament et de la compréhension de l'acquisition et de la transmission du savoir. Le développement du phytomédicament non toxique destiné à l'homme et à l'animal figure également parmi les enjeux majeurs de demain. The origin of traditional pharmacopoeias The development of pharmacopoeias The medicines of the XXIth century How have the traditional Therapeutical knowledges been transmited to the différent cultures? This innovating book containing the proceedings of the 4th European Congress of Ethnopharmacology return to prehistory the sources of fherapeutical knowledge and asks how the animals cure themselves with plants. If the printing pharmacopoeias ponctuate the history of learning medicines other way of accessibility to the knowledge seems exist in the world of shaman in society with oral tradition. Ethnopharmacological evaluation of traditional médicinal plant should favour the development of phytomedicine. The purpose of this publication is also to provide dues to scientists in the whole world and help them identify new avenues for research in the field of the prehistory of drugs, for a better understanding of the way knowledge is acquired and then transmitted, and for the development of non-toxic herbal medicines for administration to human and animal beings.

Published
2002

49. Activity of Berberis aetnensis root extracts on Candida strains

Author

Iauk, L, Costanzo, R, Caccamo, F, Rapisarda, A, Musumeci, R, Milazzo, I, Blandino, G, Blandino, G., MUSUMECI, ROSARIO, Iauk, L, Costanzo, R, Caccamo, F, Rapisarda, A, Musumeci, R, Milazzo, I, Blandino, G, Blandino, G., and MUSUMECI, ROSARIO

Abstract

The antifungal activity of methanolic extract and alkaloidal fraction of Berberis aetnensis against Candida species was investigated. The crude extract was active against Candida species, this activity being higher than that of the alkaloidal fraction and berberine

Published
2007

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