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1. Hipertensión portal: recomendaciones de diagnóstico y tratamiento. Documento de consenso de la Asociación Española para el Estudio del Hígado (AEEH) y el Centro para la Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)

Author

Alvarado-Tapias, Edilmar, Ampuero, Javier, Baiges, Anna, Bellot, Pablo, Calleja, José Luis, Cárdena, Andrés, Catalina, María-Vega, Escorsell, Àngels, Fortea, José Ignacio, García-Pagan, Juan Carlos, Genescà, Juan, Hernández-Guerra, Manuel, Ibáñez-Samaniego, Luis, Lens, Sabela, Llop, Elba, Simon-Talero, Macarena, Martín-Mateos, Rosa, Pons, Mónica, Pose, Elisa, Puente, Angela, Reverter, Enric, Rincón, Diego, Rodríguez-Gandía, Miguel Ángel, Téllez, Luis, Turón, Fanny, Villanueva, Cándido, Albillos, Agustín, Bañares, Rafael, and Hernández-Gea, Virginia

Published
2025
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2. Impact of SARS-CoV-2 vaccination in patients with vascular liver diseases: Observations from a VALDIG multicenter study

Author

Perez-Campuzano, Valeria, Rautou, Pierre-Emmanuel, Marjot, Thomas, Praktiknjo, Michael, Alvarado-Tapias, Edilmar, Turco, Laura, Ibáñez-Samaniego, Luis, González-Alayón, Carlos, Puente, Ángela, Llop, Elba, Simón-Talero, Macarena, Álvarez-Navascués, Carmen, Reiberger, Thomas, Verhelst, Xavier, Tellez, Luis, Bergmann, Johanna Birte, Orts, Lara, Grassi, Giuseppe, Baiges, Anna, Audrey, Payance, Trebicka, Jonel, Villanueva, Candid, Morelli, Maria Cristina, Murray, Sam, Meacham, Georgina, Luetgehetmann, Marc, Schulze zur Wiesch, Julian, García-Pagán, Juan-Carlos, Barnes, Eleanor, Plessier, Aurélie, and Hernández-Gea, Virginia

Published
2024
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3. Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD

Author

Paternostro, Rafael, Kwanten, Wilhelmus J., Hofer, Benedikt Silvester, Semmler, Georg, Bagdadi, Ali, Luzko, Irina, Hernández-Gea, Virginia, Graupera, Isabel, García-Pagán, Juan Carlos, Saltini, Dario, Indulti, Federica, Schepis, Filippo, Moga, Lucile, Rautou, Pierre-Emmanuel, Llop, Elba, Téllez, Luis, Albillos, Agustín, Fortea, Jose Ignacio, Puente, Angela, Tosetti, Giulia, Primignani, Massimo, Zipprich, Alexander, Vuille-Lessard, Elise, Berzigotti, Annalisa, Taru, Madalina-Gabriela, Taru, Vlad, Procopet, Bogdan, Jansen, Christian, Praktiknjo, Michael, Gu, Wenyi, Trebicka, Jonel, Ibanez-Samaniego, Luis, Bañares, Rafael, Rivera-Esteban, Jesús, Pericas, Juan M., Genesca, Joan, Alvarado, Edilmar, Villanueva, Candid, Larrue, Helene, Bureau, Christophe, Laleman, Wim, Ardevol, Alba, Masnou, Helena, Vanwolleghem, Thomas, Trauner, Michael, Mandorfer, Mattias, Francque, Sven, and Reiberger, Thomas

Published
2024
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5. Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on- chronic liver failure

Author

Agarwal, Banwari, Cañizares, Rafael Bañares, Saliba, Faouzi, Ballester, Maria Pilar, Tomescu, Dana Rodica, Martin, Daniel, Stadlbauer, Vanessa, Wright, Gavin, Sheikh, Mohammed, Morgan, Carrie, Alzola, Carlos, Lavin, Phillip, Green, Daniel, Kumar, Rahul, Sacleux, Sophie Caroline, Schilcher, Gernot, Koball, Sebastian, Tudor, Andrada, Minten, Jaak, Domenech, Gema, Aragones, Juan Jose, Oettl, Karl, Paar, Margret, Waterstradt, Katja, Bode-Boger, Stefanie M., Ibáñez-Samaniego, Luis, Gander, Amir, Ramos, Carolina, Chivu, Alexandru, Stange, Jan, Lamprecht, Georg, Sanchez, Moises, Mookerjee, Rajeshwar P., Davenport, Andrew, Davies, Nathan, Pavesi, Marco, Andreola, Fausto, Albillos, Agustin, Cordingley, Jeremy, Schmidt, Hartmut, Carbonell-Asins, Juan Antonio, Arroyo, Vicente, Fernandez, Javier, Mitzner, Steffen, and Jalan, Rajiv

Published
2023
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7. Non-invasive tests for clinically significant portal hypertension after HCV cure

Author

Semmler, Georg, Lens, Sabela, Meyer, Elias L., Baiges, Anna, Alvardo-Tapias, Edilmar, Llop, Elba, Tellez, Luis, Schwabl, Philipp, Mauro, Ezequiel, Escudé, Laia, Díez, Cristina, Ibañez-Samaniego, Luis, Puente, Ángela, Fortea, José Ignacio, Abadía, Marta, Zanetto, Alberto, Conthe, Andrés, Hernandez-Évole, Helena, Luzko Scheid, Irina Sofia, Jia, Jidong, Yoshiji, Hitoshi, Francque, Sven M., Tsochatzis, Emmanuel A., Russo, Francesco Paolo, Crespo, Gonzalo, Forns, Xavier, Bañares, Rafael, Villanueva, Càndid, Hernández-Gea, Virginia, Reiberger, Thomas, Bosch, Jaume, García Pagán, Juan Carlos, and Mandorfer, Mattias

Published
2022
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8. Bacterial infections in patients with acute variceal bleeding in the era of antibiotic prophylaxis

Author

Martínez, Javier, Hernández-Gea, Virginia, Rodríguez-de-Santiago, Enrique, Téllez, Luis, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibañez-Samaniego, Luis, Silva-Junior, Gilberto, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Bañares, Rafael, Krag, Aleksander, Llop, Elba, Laleman, Wim, Palazon, Jose María, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Noronha-Ferreira, Carlos, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Schwarzer, Remy, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Romero-Gomez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Nevens, Frederik, Calleja, Jose Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, Maria Vega, Rudler, Marika, Alvarado, Edilmar, Perez-Campuzano, Valeria, Guardascione, Maria Anna, Fischer, Petra, Bosch, Jaime, García-Pagán, Juan Carlos, and Albillos, Agustín

Published
2021
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9. Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data

Author

Bureau, Christophe, Abraldes, Juan G., Nevens, Frederik, Caca, Karel, Laleman, Wim, Appenrodt, Beate, Luca, Angelo, Vinel, Jean Pierre, Mössner, Joachim, Di Pascoli, Marco, Zipprich, Alexander, Sauerbruch, Tilman, Martinez-Lagares, Francisco, Ruiz-del-Arbol, Luis, Sierra, Angel, Guevara, Clemencia, Jimenez, Elena, Marrero, Jose Miguel, Buceta, Enrique, Sanchez, Juan, Castellot, Ana, Penate, Monica, Cruz, Ana, Pena, Elena, Procopeț, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Ibañez-Samaniego, Luis, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Trebicka, Jonel, Llop, Elba, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell’Era, Alessandra, Senzolo, Marco, Romero-Gómez, Manuel, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Calleja, Jose Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, Maria-Vega, Albillos, Agustin, Alvarado, Edilmar, Guardascione, Maria Anna, Tanțău, Marcel, Zuo, Luo, Zhu, Xuan, Zhao, Jianbo, Xue, Hui, Jiang, Zaibo, Zhuge, Yuzheng, Zhang, Chunqing, Sun, Junhui, Ding, Pengxu, Ren, Weixin, Li, Yingchun, Zhang, Kewei, Zhang, Wenguang, He, Chuangye, Zhong, Jiawei, Peng, Qifeng, Ma, Fuquan, Luo, Junyang, Zhang, Ming, Wang, Guangchuan, Sun, Minhuang, Dong, Junjiao, Bai, Wei, Guo, Wengang, Wang, Qiuhe, Yuan, Xulong, Wang, Zhengyu, Yu, Tianlei, Luo, Bohan, Li, Xiaomei, Yuan, Jie, Han, Na, Zhu, Ying, Niu, Jing, Li, Kai, Yin, Zhanxin, Nie, Yongzhan, Fischer, Petra, Horia Ștefănescu, Pop, Andreea, Laursen, Stig B., Turon, Fanny, Baiges, Anna, Ferrusquía-Acosta, José, Magaz, Marta, Cerda, Eira, Tellez, Luis, Allegretti, Giulia, Macedo, Guilherme, Haldrup, David, Santos, Patricia, Moura, Miguel, Reis, Daniela, Meireles, Liliane, Sousa, Patricia, Alexandrino, Paula, Navascues, Carmen, Augustin, Salvador, La Mura, Vincenzo, Bañares, Rafael, Diaz, Raquel, Gómez, Marta López, Ripoll, Cristina, Nicoară-Farcău, Oana, Han, Guohong, Rudler, Marika, Angrisani, Debora, Monescillo, Alberto, Torres, Ferran, Casanovas, Georgina, Bosch, Jaime, Lv, Yong, Thabut, Dominique, Fan, Daiming, Hernández-Gea, Virginia, and García-Pagán, Juan Carlos

Published
2021
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10. Clinical outcome and hemodynamic changes following HCV eradication with oral antiviral therapy in patients with clinically significant portal hypertension

Author

Lens, Sabela, Baiges, Anna, Alvarado-Tapias, Edilmar, LLop, Elba, Martinez, Javier, Fortea, Jose Ignacio, Ibáñez-Samaniego, Luís, Mariño, Zoe, Rodríguez-Tajes, Sergio, Gallego, Adolfo, Bañares, Rafael, Puente, Ángela, Albillos, Agustín, Calleja, Jose Luis, Torras, Xavier, Hernández-Gea, Virginia, Bosch, Jaume, Villanueva, Cándid, García-Pagán, Juan Carlos, and Forns, Xavier

Published
2020
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12. Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Author

Trebicka, Jonel, Gu, Wenyi, Ibáñez-Samaniego, Luis, Hernández-Gea, Virginia, Pitarch, Carla, Garcia, Elisabet, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Cristophe, Llop, Elba, Laleman, Wim, Palazon, Jose Maria, Castellote, Jose, Rodrigues, Susanag, Gluud, Liselotte, Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Weiss, Emmanuel, Catalina, Maria-Vega, Erasmus, Hans-Peter, Uschner, Frank Erhard, Schulz, Martin, Brol, Maximilian J., Praktiknjo, Michael, Chang, Johannes, Krag, Aleksander, Nevens, Frederik, Calleja, Jose Luis, Robic, Marie Angèle, Conejo, Irene, Albillos, Agustin, Rudler, Marika, Alvarado, Edilmar, Guardascione, Maria Anna, Tantau, Marcel, Bosch, Jaime, Torres, Ferran, Pavesi, Marco, Garcia-Pagán, Juan Carlos, Jansen, Christian, and Bañares, Rafael

Published
2020
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13. Pregnancy outcomes in patients with portal cavernoma: A case series study

Author

Conthe, Andrés, Ibáñez‐Samaniego, Luis, Fernández Muñoz, María, Ortega, Virginia, Fernández Yunquera, Ainhoa, Romero, Mario, Yllana, Fátima, Vega Catalina,Maria, García‐Tizón Larroca, Santiago, Bañares Cañizares, Rafael, Conthe, Andrés, Ibáñez‐Samaniego, Luis, Fernández Muñoz, María, Ortega, Virginia, Fernández Yunquera, Ainhoa, Romero, Mario, Yllana, Fátima, Vega Catalina,Maria, García‐Tizón Larroca, Santiago, and Bañares Cañizares, Rafael

Abstract

Objective: Non-cirrhotic portal vein cavernoma (PVC) is a cause of portal hypertension (PH) frequently affecting women of childbearing age. Cavernous transformation of the portal vein is frequently associated with prothrombotic disorders and often entails multiple hemodynamic changes, porto-collateral shunt development and thrombopenia, all of which can affect the course of pregnancy. Our aim was to evaluate the risk of PH-related complications and pregnancy outcomes in patients with PVC. Methods: Retrospective case series study of patients with PVC undergoing pregnancy in a tertiary care hospital. Results: Eight pregnancies fulfilled the eligibility criteria. All patients had a predisposing factor for PVC. One episode of variceal bleeding was reported at week 28. Six cesarean sections were scheduled to avoid labor while two urgent surgeries were indicated due to fetal distress and intrauterine growth restriction (IUGR). In all but one case, anticoagulation was prescribed after delivery. No hemorrhagic or thrombotic complications were reported. There were four cases of IUGR with no case of miscarriage or stillbirth. Conclusion: Pregnancy in patients with PVC has an overall favorable outcome albeit a higher risk of PH-derived complications, and IUGR may be expected. Hence, PVC must not be considered a contraindication for pregnancy although larger prospective studies are necessary., Depto. de Medicina, Fac. de Medicina, TRUE, pub, APC financiada por la UCM

Published
2024

14. Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on-chronic liver failure

Author

Agarwal, Banwari, Bañares Cañizares, Rafael, Ibáñez Samaniego, Luis, Jalan, Rajiv, Agarwal, Banwari, Bañares Cañizares, Rafael, Ibáñez Samaniego, Luis, and Jalan, Rajiv

Abstract

Se trata de un artículo que describe, por primera vez en humanos, la seguridad y el impacto fisiopatológico de un nuevo dispositivo de soporte hepático artificial, diseñado específicamente para antagonizar los mecanismos fisiopatológicos de la cirrosis descompensada. El estudio , financiado mediante un proyecto europeo, indica que el dispositivo es seguro, aplicable, tiene influencia en los numerosos aspectos mecanísticos explorados y, finalmente, apuntando a datos de posible eficacia clínica. Globalmente, se puede considerar que el estudio es una evidente prueba de concepto positiva. Desde el punto de vista de la trascendencia social y sanitaria, si los estudios en fase III determinan la eficacia sobre variables clínicas, representaría una herramienta de gran valor para el tratamiento de pacientes con cirrosis y con fracaso hepático agudo sobre crónico. La revista Journal of Hepatology está en el primer decil de la especialidad con un FI de XXX. El investigador solicitante del sexenio es primer firmante del artículo habiendo participado en el diseño y ejecución del proyecto así como en la elaboración de los resultados y del manuscrito en todas sus fases. Representa además la continuacion en una línea de investigación con numerosas publicaciones previas (Banares R et al. Hepatology 2013; Saliba F, Bañares R et al. Intensive Care Medicine 2022), Background & Aims: Acute-on-chronic liver failure (ACLF) is characterized by severe systemic inflammation, multi-organ failure and high mortality rates. Its treatment is an urgent unmet need. DIALIVE is a novel liver dialysis device that aims to exchange dysfunctional albumin and remove damage- and pathogen-associated molecular patterns. This first-in-man randomizedcontrolled trial was performed with the primary aim of assessing the safety of DIALIVE in patients with ACLF, with secondary aims of evaluating its clinical effects, device performance and effect on pathophysiologically relevant biomarkers. Methods: Thirty-two patients with alcohol-related ACLF were included. Patients were treated with DIALIVE for up to 5 days and end points were assessed at Day 10. Safety was assessed in all patients (n = 32). The secondary aims were assessed in a prespecified subgroup that had at least three treatment sessions with DIALIVE (n = 30). Results: There were no significant differences in 28-day mortality or occurrence of serious adverse events between the groups. Significant reduction in the severity of endotoxemia and improvement in albumin function was observed in the DIALIVE group, which translated into a significant reduction in the CLIF-C (Chronic Liver Failure consortium) organ failure (p = 0.018) and CLIF-C ACLF scores (p = 0.042) at Day 10. Time to resolution of ACLF was significantly faster in DIALIVE group (p = 0.036). Biomarkers of systemic inflammation such as IL-8 (p = 0.006), cell death [cytokeratin-18: M30 (p = 0.005) and M65 (p = 0.029)], endothelial function [asymmetric dimethylarginine (p = 0.002)] and, ligands for Toll-like receptor 4 (p = 0.030) and inflammasome (p = 0.002) improved significantly in the DIALIVE group. Conclusions: These data indicate that DIALIVE appears to be safe and impacts positively on prognostic scores and pathophysiologically relevant biomarkers in patients with ACLF. Larger, adequately powered studies are warranted to further confi, Unión Europea, Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2024

15. A simple nomogram identifies patients with refractory ascites with worse outcome after transjugular intrahepatic portosystemic shunt

Author

Aicart-Ramos, Marta, Ibáñez-Samaniego, Luis, Hernández-Gea, Virginia, Martínez-Lozano, Helena, Rodríguez-de-Santiago, Enrique, Catalina, María-Vega, Martínez González, Javier, Echenagusia-Boyra, Miguel-Jesús, Mezzano Puentes, Gabriel, Ferrusquía-Acosta, José, Olavarría, Andreína, Blázquez Sánchez, Javier, García-Pagán, Juan Carlos, Bañares, Rafael, and Albillos, Agustín

Published
2021
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20. Pregnancy outcomes in patients with portal cavernoma: A case series study

Author

Conthe, Andrés, Ibáñez‐Samaniego, Luis, Fernández Muñoz, María, Ortega, Virginia, Fernández Yunquera, Ainhoa, Romero, Mario, Yllana, Fátima, Vega Catalina,Maria, García‐Tizón Larroca, Santiago, Bañares Cañizares, Rafael, Conthe, Andrés, Ibáñez‐Samaniego, Luis, Fernández Muñoz, María, Ortega, Virginia, Fernández Yunquera, Ainhoa, Romero, Mario, Yllana, Fátima, Vega Catalina,Maria, García‐Tizón Larroca, Santiago, and Bañares Cañizares, Rafael

Abstract

Objective: Non-cirrhotic portal vein cavernoma (PVC) is a cause of portal hypertension (PH) frequently affecting women of childbearing age. Cavernous transformation of the portal vein is frequently associated with prothrombotic disorders and often entails multiple hemodynamic changes, porto-collateral shunt development and thrombopenia, all of which can affect the course of pregnancy. Our aim was to evaluate the risk of PH-related complications and pregnancy outcomes in patients with PVC. Methods: Retrospective case series study of patients with PVC undergoing pregnancy in a tertiary care hospital. Results: Eight pregnancies fulfilled the eligibility criteria. All patients had a predisposing factor for PVC. One episode of variceal bleeding was reported at week 28. Six cesarean sections were scheduled to avoid labor while two urgent surgeries were indicated due to fetal distress and intrauterine growth restriction (IUGR). In all but one case, anticoagulation was prescribed after delivery. No hemorrhagic or thrombotic complications were reported. There were four cases of IUGR with no case of miscarriage or stillbirth. Conclusion: Pregnancy in patients with PVC has an overall favorable outcome albeit a higher risk of PH-derived complications, and IUGR may be expected. Hence, PVC must not be considered a contraindication for pregnancy although larger prospective studies are necessary., Depto. de Medicina, Fac. de Medicina, TRUE, pub, APC financiada por la UCM

Published
2023

22. Alcohol-related liver disease phenotype impacts survival after an acute variceal bleeding episode

Author

Instituto de Salud Carlos III, Villagrasa, Ares, Hernández-Gea, Virginia, Bataller, Ramón, Giráldez, Álvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibáñez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazón, Jose María, Castellote, José, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos N., Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, José Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Alessandra Dell'Era, Senzolo, Marco, Abraldes, Juan G., Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gómez, Manuel, Tantau, Marcel, Guardascione, Maria Anna, Alvarado, Edilmar, Rudler, Marika, Bañares, Rafael, Martínez, Javier, Robic, Marie Angèle, Jansen, Christian, Calleja, José Luis, Nevens, Frederik, Bosch, Jaime, Ventura-Cots, Meritxell, García-Pagán, Juan Carlos, Genescà, Joan, for the International Variceal Bleeding Observational Study Group; Baveno Cooperation, Instituto de Salud Carlos III, Villagrasa, Ares, Hernández-Gea, Virginia, Bataller, Ramón, Giráldez, Álvaro, Procopet, Bogdan, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibáñez-Samaniego, Luis, Albillos, Agustin, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazón, Jose María, Castellote, José, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos N., Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, José Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Alessandra Dell'Era, Senzolo, Marco, Abraldes, Juan G., Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Krag, Aleksander, Silva-Junior, Gilberto, Romero-Gómez, Manuel, Tantau, Marcel, Guardascione, Maria Anna, Alvarado, Edilmar, Rudler, Marika, Bañares, Rafael, Martínez, Javier, Robic, Marie Angèle, Jansen, Christian, Calleja, José Luis, Nevens, Frederik, Bosch, Jaime, Ventura-Cots, Meritxell, García-Pagán, Juan Carlos, Genescà, Joan, and for the International Variceal Bleeding Observational Study Group; Baveno Cooperation

Abstract

[Background & Aims] Alcohol-related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol-related liver disease (ALD) phenotypes and viral cirrhosis., [Methods] Multicentre, observational study including 916 patients with AVB falling under the next categories: AH (n = 99), ALD cirrhosis actively drinking (d-ALD) (n = 285), ALD cirrhosis abstinent from alcohol (a-ALD) (n = 227) and viral cirrhosis (n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD., [Results] The prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty-two days transplant-free survival was worse among AH, but statistical differences were only observed between AH and d-ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one-year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a-ALD (0.48; 0.29–0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH., [Conclusions] Contrary to expected, AH patients with AVB present no worse one-year survival than other patients with different alcohol-related phenotypes or viral cirrhosis. Abstinence influences long-term survival and could explain these counterintuitive results.

Published
2023

23. Pregnancy outcomes in patients with portal cavernoma: A case series study

Author

Conthe, Andrés, primary, Ibáñez‐Samaniego, Luis, additional, Muñoz, María Fernández, additional, Ortega, Virginia, additional, Yunquera, Ainhoa Fernández, additional, Romero, Mario, additional, Yllana, Fátima, additional, Catalina, Maria Vega, additional, Larroca, Santiago García‐Tizón, additional, and Bañares, Rafael, additional

Published
2023
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24. CT-derived liver and spleen volume accurately diagnose clinically significant portal hypertension in patients with hepatocellular carcinoma

Author

Romero-Cristóbal, Mario, primary, Clemente-Sánchez, Ana, additional, Ramón, Enrique, additional, Téllez, Luis, additional, Canales, Elena, additional, Ortega-Lobete, Olga, additional, Velilla-Aparicio, Elena, additional, Catalina, María-Vega, additional, Ibáñez-Samaniego, Luis, additional, Alonso, Sonia, additional, Colón, Arturo, additional, Matilla, Ana-María, additional, Salcedo, Magdalena, additional, Albillos, Agustín, additional, Bañares, Rafael, additional, and Rincón, Diego, additional

Published
2023
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29. Global multi-stakeholder endorsement of the MAFLD definition

Author

Abate, Maria Lorena, Abbas, Bahaa, Abbassy, Ahmed Amr, Abd El Ghany, Waleed, Abd Elkhalek, Amira, Abd ElMajeed, Emad, Abdalgaber, Mohammad, AbdAllah, Mohamed, Abdallah, Marwa, Abdallah, Nourhan, Abdelaleem, Shereen, Abdelghani, Yasser, Abdelghany, Wael, Abdelhalim, Safaa Mohamed, Abdelhamid, Wafaa, Abdelhamid, Nehal, Abdelkader, Nadia A., Abdelkreem, Elsayed, Abdelmohsen, Aly Mohamed, Abdelrahman, Awny Ali, Abd-elsalam, Sherief M, Abdeltawab, Doaa, Abduh, Abdulbaset, Abdulhakam, Nada, Abdulla, Maheeba, Abedpoor, Navid, Abenavoli, Ludovico, Åberg, Fredrik, Ablack, Omala, Abo elftouh, Mostafa, Abo-Amer, Yousry Esam-Eldin, Aboubkr, Ashraf, Aboud, Alaa, Abouelnaga, Amr M., Aboufarrag, Galal A., Aboutaleb, Ashraf, Abundis, Leticia, Adalı, Gupse, Adames, Enrique, Adams, Leon, Adda, Danjuma, Adel, Noor, Adel, Nada, Adel Sayed, Muhammad, Afaa, Taiba Jibril, Afredj, Nawal, Aghayeva, Gulnara, Aghemo, Alessio, Aguilar-Salinas, Carlos A., Ahlenstiel, Golo, Ahmady, Walid, Ahmed, Wafaa, Ahmed, Amira, Ahmed, Samah Nasser, Ahmed, Heba Mostafa, Ahmed, Rasha, Aigner, Elmar, Akarsu, Mesut, Akroush, Maisam, Akyuz, Umit, Al Mahtab, Mamun, Al Qadiri, Tahani, Al Rawahi, Yusriya, AL rubaee, Razzaq, Al Saffar, Muna, Alam, Shahinul, Al-Ani, Zaid, Albillos, Agustín, Alboraie, Mohamed, Al-Busafi, Said, Al-Emam, Mohamed, Alharthi, Jawaher, Ali, Kareem, Ali, Basma Abdelmoez, Ali, Mohammad, Ali, Raja Affendi Raja, Alisi, Anna, AL-Khafaji, Ali Raad, Alkhatry, Maryam, Aller, Rocio, Almansoury, Yahya, Al-Naamani, Khalid, Alnakeeb, Alaa, Alonso, Anna, Alqahtani, Saleh A., Alrabadi, Leina, Alswat, Khalid, Altaher, Mahir, Altamimi, Turki, Altamirano, Jose, Alvares-da-Silva, Mario R., Aly, Elsragy Adel M., Alzahaby, Amgad, Alzamzamy, Ahmed, Amano, Keisuke, Amer, Maysa A., Amin, Mona A., Amin, Sayed A., Amir, Ashraf A., Ampuero, Javier, Anas, Noha, Andreone, Pietro, Andriamandimby, Soa Fy, Anees, Mahmoud, Angela, Peltec, Antonios, Manal, Arafat, Wael, Araya, Jose Moreno, Armendariz-Borunda, Juan, Armstrong, Matthew J., Ashktorab, Hassan, Aspichueta, Patricia, Assal, Fathia, Atef, Mira, Attia, Dina, Atwa, Hoda, Awad, Reham, Awad, Mohyeldeen Abd Elaziz, Awny, Sally, Awolowo, Obafemi, Awuku, Yaw Asante, Ayada, Ibrahim, Aye, Than Than, Ayman, Sherif, Ayman, Hedy, Ayoub, Hesham, Azmy, Hosny M., Babaran, Romiro P., Badreldin, Omneya, Badry, Ahmed, Bahçecioğlu, İbrahim Halil, Bahour, Amira, Bai, Jiajia, Balaban, Yasemin, Balasubramanyam, Muthuswamy, Bamakhrama, Khaled, Banales, Jesus M, Bangaru, Babu, Bao, Jianfeng, Barahona, Jorge Suazo, Barakat, Salma, Barbalho, Sandra Maria, Barbra, Bikwa, Barranco, Beatriz, Barrera, Francisco, Baumann, Ulrich, Bazeed, Shamardan, Bech, Eva, Benayad, Aourarh, Benesic, Andreas, Bernstein, David, Bessone, Fernando, Birney, Susie, Bisseye, Cyrille, Blake, Martin, Bobat, Bilal, Bonfrate, Leonilde, Bordin, Dmitry S, Bosques-Padilla, Francisco, Boursier, Jerome, Boushab, Boushab Mohamed, Bowen, David, Bravo, Patricia Medina, Brennan, Paul N, Bright, Bisi, Broekaert, Ilse, Buque, Xabier, Burgos-Santamaría, Diego, Burman, Julio, Busetto, Luca, Byrne, Chris D., Cabral-Prodigalidad, Patricia Anne I., Cabrera-Alvarez, Guillermo, Cai, Wei, Cainelli, Francesca, Caliskan, Ali Riza, Canbay, Ali, Cano-Contreras, Ana, Cao, Hai-Xia, Cao, Zhujun, Carrion, Andres, Carubbi, Francesca, Casanovas, Teresa, Castellanos Fernández, Marlen Ivón, Chai, Jin, Chan, Siew Pheng, Charatcharoenwitthaya, Phunchai, Chavez-Tapia, Norberto, Chayama, Kazuaki, Chen, Jinjun, Chen, Lin, Chen, Zhong-Wei, Chen, Huiting, Chen, Sui-Dan, Chen, Qiang, Chen, Yaxi, Chen, Gang, Chen, En-Quang, Chen, Fei, Chen, Pei-Jer, Cheng, Robert, Cheng, Wendy, Chieh, Jack Tan Wei, Chokr, Imad, Cholongitas, Evangelos, Choudhury, Ashok, Chowdhury, Abhijit, Chukwudike, Evaristus Sunday, Ciardullo, Stefano, Clayton, Michelle, Clement, Karine, Cloa, Marie Michelle, Coccia, Cecilia, Collazos, Cristina, Colombo, Massimo, Cosar, Arif Mansur, Cotrim, Helma Pinchemel, Couillerot, Joris, Coulibaly, Alioune, Crespo, Gonzalo, Crespo, Javier, Cruells, Maria, Cua, Ian Homer Y., Dabbous, Hesham K., Dalekos, George N, D'Alia, Patricia, Dan, Li, Dao, Viet Hang, Darwish, Mostafa, Datz, Christian, Davalos-Moscol, Milagros B, Dawoud, Heba, de Careaga, Blanca Olaechea, de Knegt, Robert, de Ledinghen, Victor, de Silva, Janaka, Debzi, Nabil, Decraecker, Marie, Del Pozo, Elvira, Delgado, Teresa C, Delgado-Blanco, Manuel, Dembiński, Łukasz, Depina, Adilson, Derbala, Moutaz, Desalegn, Hailemichael, Desbois-Mouthon, Christèle, Desoky, Mahmoud, Dev, Anouk, Di Ciaula, Agostino, Diago, Moisés, Diallo, Ibrahima, Díaz, Luis Antonio, Dirchwolf, Melisa, Dongiovanni, Paola, Dorofeyev, Andrriy, Dou, Xiaoguang, Douglas, Mark W., Doulberis, Michael, Dovia, Cecil K., Doyle, Adam, Dragojević, Ivana, Drenth, Joost PH, Duan, Xuefei, Dulskas, Audrius, Dumitrascu, Dan L, Duncan, Oliver, Dusabejambo, Vincent, Dwawhi, Rev. Shem N.A., Eiketsu, Sho, El Amrousy, Doaa, El Deeb, Ahmed, El Deriny, Ghada, El Din, Hesham Salah, El Kamshishy, Salwa, El Kassas, Mohamed, El Raziky, Maissa, Elagamy, Osama A, Elakel, Wafaa, Elalfy, Dina, Elaraby, Hanaa, ElAwady, Heba, Elbadawy, Reda, Eldash, Hanaa Hassan, Eldefrawy, Manal S., Elecharri, Carol Lezama, Elfaramawy, Amel, Elfatih, Mohammed, Elfiky, Mahmoud, Elgamsy, Mohamed, Elgendy, Mohamed, El-Guindi, Mohamed A., Elhussieny, Nagi, Eliwa, Ahmed Maher, Elkabbany, Zeineb, El-Khayat, Hesham, El-Koofy, Nehal M., Elmetwalli, Alaa, Elrabat, Amr, El-Raey, Fathiya, Elrashdy, Fatma, Elsahhar, Medhat, Elsaid, Esraa M., Elsayed, Shimaa, Elsayed, Hany, Elsayed, Aly, Elsayed, Amr M., Elsayed, Hamdy, El-Serafy, Magdy, Elsharkawy, Ahmed M., Elsheemy, Reem Yehia, Elshemy, Eman Elsayed, Elsherbini, Sara, Eltoukhy, Naglaa, Elwakil, Reda, Emad, Ola, Emad, Shaimaa, Embabi, Mohamed, Ergenç, Ilkay, Ermolova, Tatiana, Esmat, Gamal, Esmat, Doaa M., Estupiñan, Enrique Carrera, Ettair, Said, Eugen, Tcaciuc, Ezz-Eldin, Mohammed, Falcón, Lidia Patricia Valdivieso, Fan, Yu-Chen, Fandari, Samah, Farag, Mahmoud, Farahat, Taghreed Mohamed, Fares, Eman M., Fares, Michael, Fassio, Eduardo, Fathy, Hayam, Fathy, Dina, Fathy, Wael, Fayed, Soheir, Feng, Dan, Feng, Gong, Fernández-Bermejo, Miguel, Ferreira, Cristina Targa, Ferrer, Javier Díaz, Forbes, Alastair, Fouad, Rabab, Fouad, Hanan M., Frisch, Tove, Fujii, Hideki, Fukunaga, Shuhei, Fukunishi, Shinya, Fulya, Hacer, Furuhashi, Masato, Gaber, Yasmine, Galang, Augusto Jose G., Gallardo, Jacqueline Cordova, Galloso, Rocío, Gamal, Mahmoud, Gamal, Reham, Gamal, Hadeel, Gan, Jian, Ganbold, Anar, Gao, Xin, Garas, George, Garba, Tony, García-Cortes, Miren, García-Monzón, Carmelo, García-Samaniego, Javier, Gastaldelli, Amalia, Gatica, Manuel, Gatley, Elizabeth, Gegeshidze, Tamar, Geng, Bin, Ghazinyan, Hasmik, Ghoneem, Salma, Giacomelli, Luca, Giannelli, Gianluigi, Giannini, Edoardo G., Giefer, Matthew, Ginès, Pere, Girala, Marcos, Giraudi, Pablo J, Goh, George Boon-Bee, Gomaa, Ahmed Ali, Gong, Benbingdi, Gonzales, Dina Hilda C., Gonzalez, Humberto C., Gonzalez-Huezo, Maria Saraí, Graupera, Isabel, Grgurevic, Ivica, Grønbæk, Henning, Gu, Xuelian, Guan, Lin, Gueye, Ibrahima, Guingané, Alice Nanelin, Gul, Ozen Oz, Gul, Cuma Bulent, Guo, Qing, Gupta, Pramendra Prasad, Gurakar, Ahmet, Gutierrez, Juan Carlos Restrepo, Habib, Ghada, Hafez, Azaa, Hagman, Emilia, Halawa, Eman, Hamdy, Osama, Hamed, Abd Elkhalek, Hamed, Dina H., Hamid, Saeed, Hamoudi, Waseem, Han, Yu, Haridy, James, Haridy, Hanan, Harris, David C H Harris, Hart, Michael, Hasan, Fuad, Hashim, Almoutaz, Hassan, Israa, Hassan, Ayman, Hassan, Essam Ali, Hassan, Adel Ahmed, Hassan, Magda Shehata, Hassanin, Fetouh, Hassnine, Alshymaa, Haukeland, John Willy, Hawal, Amr Ismael M., He, Jinfan, He, Qiong, He, Yong, He, Fang-Ping, Hegazy, Mona, Hegazy, Adham, Henegil, Osama, Hernández, Nelia, Hernández-Guerra, Manuel, Higuera-de-la-Tijera, Fatima, Hindy, Ibrahim, Hirota, Keisuke, Ho, Lee Chi, Hodge, Alexander, Hosny, Mohamed, Hou, Xin, Huang, Jiao-Feng, Huang, Yan, Huang, Zhifeng, Huang, Yuan, Huang, Ang, Huang, Xiao-Ping, Hui-ping, Sheng, Hunyady, Bela, Hussein, Mennatallah A., Hussein, Osama, Hussien, Shahinaz Mahmoud, Ibáñez-Samaniego, Luis, Ibdah, Jamal, Ibrahim, Luqman, Ibrahim, Miada, Ibrahim, Ibrahim, Icaza-Chávez, Maria E., Idelbi, Sahar, Idilman, Ramazan Idilman, Ikeda, Mayumi, Indolfi, Giuseppe, Invernizzi, Federica, Irshad, Iram, Isa, Hasan Mohamed Ali, Iskandar, Natacha Jreige, Ismaiel, Abdulrahman, Ismail, Mariam, Ismail, Zulkifli, Ismail, Faisal, Iwamoto, Hideki, Jack, Kathryn, Jacob, Rachael, Jafarov, Fuad, Jafri, Wasim, Jahshan, Helen, Jalal, Prasun K, Jancoriene, Ligita, Janicko, Martin, Jayasena, Hiruni, Jefferies, Meryem, Jha, Vivekanand, Ji, Fanpu, Ji, Yaqiu, Jia, Jidong, Jiang, Changtao, Jiang, Ni, Jiang, Zong-zhe, Jin, Xing, Jin, Yi, Jing, Xu, Jingyu, Qian, Jinjolava, Maia, Jong, FX Himawan Haryanto, Jucov, Alina, Julius, Ibecheole, Kaddah, Mona, Kamada, Yoshihiro, kamal, Abobakr, Kamal, Enas Mohamed, Kamel, Ashraf Sayed, Kao, Jia-Horng, Karin, Maja, Karlas, Thomas, Kashwaa, Mohammad, Katsidzira, Leolin, Kaya, Eda, Kayasseh, M.Azzam, Keenan, Bernadette, Keklikkiran, Caglayan, Keml, William, Khalaf, Deia K., Khalefa, Rofida, Khamis, Sherin, Khater, Doaa, khattab, Hamed, Khavkin, Anatoly, Khlynova, Olga, Khmis, Nabil, Kobyliak, Nazarii, Koffas, Apostolos, Koike, Kazuhiko, Kok, Kenneth Y.Y., Koller, Tomas, Komas, Narcisse Patrice, Korochanskaya, Nataliya V., Koulla, Yannoula, Koya, Shunji, Kraft, Colleen, Kraja, Bledar, Krawczyk, Marcin, Kuchay, Mohammad Shafi, Kulkarni, Anand V, Kumar, Ashish, Kumar, Manoj, Lakoh, Sulaiman, Lam, Philip, Lan, Ling, Lange, Naomi F., Lankarani, Kamran Bagheri, Lanthier, Nicolas, Lapshyna, Kateryna, Lashen, Sameh A., Laure, Konang Nguieguia Justine, Lazebnik, Leonid, Lebrec, Didier, Lee, Samuel S., Lee, Way Seah, Lee, Yeong Yeh, Leeming, Diana Julie, Leite, Nathalie Carvalho, Leon, Roberto, Lesmana, Cosmas Rinaldi Adithya, Li, Junfeng, Li, Qiong, Li, Jun, Li, Yang-Yang, Li, Yufang, Li, Lei, Li, Min, li, Yiling, Liang, Huiqing, Lijuan, Tang, Lim, Seng Gee, Lim, Lee-Ling, Lin, Shumei, Lin, Han-Chieh, Lin, Rita, Lithy, Rania, Liu, Yaru, Liu, Yuanyuan, Liu, Xin, Liu, Wen-Yue, Liu, Shourong, Liu, Ken, Liu, Tian, Lonardo, Amedeo, López, Mariana Bravo, López-Benages, Eva, Lopez-Jaramillo, Patricio, Lu, Huimin, Lu, Lun Gen, Lu, Yan, Lubel, John, Lui, Rashid, Lupasco, Iulianna, Luzina, Elena, Lv, Xiao-Hui, Lynch, Kate, Ma, Hong-Lei, Machado, Mariana Verdelho, Maduka, Nonso, Madzharova, Katerina, Magdaong, Russellini, Mahadeva, Sanjiv, Mahfouz, Amel, Mahmood, Nik Ritza Kosai Nik, Mahmoud, Eman, Mahrous, Mohamed, Maiwall, Rakhi, Majeed, Ammar, Majumdar, Avik, Mak, Loey, Maklouf, Madiha M, Malekzadeh, Reza, Mandato, Claudia, Mangia, Alessandra, Mann, Jake, Mansour, Hala Hussien, Mansouri, Abdellah, Mantovani, Alessandro, Mao, Jun qian, Maramag, Flor, Marchesini, Giulio, Marcus, Claude, Marinho, Rui António Rocha Tato, Martinez-Chantar, Maria L, Martins, Antonieta A. Soares, Marwan, Rana, Mason, Karen Frances, Masoud, Ghadeer, Massoud, Mohamed Naguib, Matamoros, Maria Amalia, Mateos, Rosa Martín, Mawed, Asmaa, Mbanya, Jean Claude, Mbendi, Charles, McColaugh, Lone, McLeod, Duncan, Medina, Juan Francisco Rivera, Megahed, Ahmed, Mehrez, Mai, Memon, Iqbal, Merat, Shahin, Mercado, Randy, Mesbah, Ahmed, Meskini, Taoufik, Metwally, Mayada, Metwaly, Rasha, Miao, Lei, Micah, Eileen, Miele, Luca, Milivojevic, Vladimir, Milovanovic, Tamara, Mina, Yvonne L., Mishkovik, Milan, Mishriki, Amal, Mitchell, Tim, Mohamed, Alshaimaa, Mohamed, Mona, Mohamed, Sofain, Mohammed, Shady, Mohammed, Ahmed, Mohan, Viswanathan, Mohie, Sara, Mokhtar, Aalaa, Moniem, Reham, Montilla, Mabel Segura, Morales, Jose Antonio Orozco, Morata, María María Sánchez, Moreno-Planas, Jose Maria, Morise, Silvia, Mosaad, Sherif, Moselhy, Mohamed, Mostafa, Alaa Mohamed, Mostafa, Ebraheem, Mouane, Nezha, Mousa, Nasser, Moustafa, Hamdy Mahfouz, Msherif, Abeer, Muller, Kate, Munoz, Christopher, Muñoz-Urribarri, Ana Beatriz, Murillo, Omar Alfaro, Mustapha, Feisul Idzwan, Muzurović, Emir, Nabil, Yehia, Nafady, Shaymaa, Nagamatsu, Ayu, Nakajima, Atsushi, Nakano, Dan, Nan, Yuemin, Nascimbeni, Fabio, Naseef, Mirella S., Nashat, Nagwa, Natalia, Taran, Negro, Francesco, Nersesov, Alexander V., Neuman, Manuela, Ng'wanasayi, Masolwa, Ni, Yan, Nicoll, Amanda, Niizeki, Takashi, Nikolova, Dafina, Ningning, Wang, Niriella, Madunil, Nogoibaeva, K.A, Nordien, Rozeena, O Sullivan, Catherine, O'Beirne, James, Obekpa, Solomon, Ocama, Ponsiano, Ochwoto, Missiani, Ogolodom, Michael Promise, Ojo, Olusegun, Okrostsvaridze, Nana, Oliveira, Claudia P., Omaña, Raul Contreras, Omar, Omneya M., Omar, Hanaa, Omar, Mabroka, Omran, Salma, Omran, Reham, Osman, Marian Muse, Owise, Nevin, Owusu-Ansah, Theobald, Padilla- Machaca, P. Martín, Palle, Sirish, Pan, Ziyan, Pan, Xiao-Yan, Pan, Qiuwei, Papaefthymiou, Apostolis, Paquissi, Feliciano Chanana, Par, Gabriella, Parkash, Arit, Payawal, Diana, Peltekian, Kevork M., Peng, Xuebin, Peng, Liang, Peng, Ying, Pengoria, Rahul, Perez, Martina, Pérez, José Luis, Pérez, Norma Marlene, Persico, Marcello, Pessoa, Mário Guimarães, Petta, Salvatore, Philip, Mathew, Plaz Torres, Maria Corina, Polavarapu, Naveen, Poniachik, Jaime, Portincasa, Piero, Pu, Chunwen, Pürnak, Tuğrul, Purwanto, Edhie, Qi, Xiaolong, Qi, Xingshun, Qian, Zibing, Qiang, Zhao, Qiao, Zengpei, Qiao, Liang, Queiroz, Alberto, Rabiee, Atoosa, Radwan, Manal, Rahetilahy, Alain Marcel, Ramadan, Yasmin, Ramadan, Dina, Ramli, Anis Safura, Ramm, Grant A., Ran, Ao, Rankovic, Ivan, RAO, Huiying, Raouf, Sara, Ray, Sayantan, Reau, Nancy, Refaat, Ahmed, Reiberger, Thomas, Remes-Troche, Jose M, Reyes, Eira Cerda, Richardson, Ben, Ridruejo, Ezequiel, Riestra Jimenez, Sergio, Rizk, Ibrahim, Roberts, Stuart, Roblero, Juan Pablo, Robles, Jorge Alberto Prado, Rockey, Don, Rodríguez, Manuel, Rodríguez Hernández, Heriberto, Román, Eva, Romeiro, Fernando Gomes, Romeo, Stefano, Rosales-Zabal, Jose Miguel, Roshdi, Georgina R., Rosso, Natalia, Ruf, Andres, Ruiz, Patricia Cordero, Runes, Nelia R., Ruzzenente, Andrea, Ryan, Marno, Saad, Ahmed, Sabbagh, Eman BE, Sabbah, Meriam, Saber, Shimaa, Sabrey, Reham, Sabry, Ramy, Saeed, Maysaa Abdallah, Said, Dina, Said, Ebada M, Sakr, Mohammad Amin, Salah, Yara, Salama, Rabab Maamoun, Salama, Asmaa, Saleh, Hussein, Saleh, Ahmed, Salem, Ahmed, Salem, Ahmed Thabet, Salifou, Alkassoum, Salih, Aso Faeq, Salman, Abdallah, Samouda, Hanen, Sanai, Faisal, Sánchez-Ávila, Juan Francisco, Sanker, Lakshumanan, Sano, Tomoya, Sanz, Miquel, Saparbu, Tobokalova, Sawhney, Rohit, Sayed, Fatma, Sayed, Sayed A., Sayed, Ashraf Othman, Sayed, Manar, Sebastiani, Giada, Secadas, Laura, Sediqi, Khawaja Qamaruddin, Seif, Sameh, Semida, Nady, Şenateş, Ebubekir, Serban, Elena Daniela, Serfaty, Lawrence, Seto, Wai-Kay, Sghaier, Ikram, Sha, Min, Shabaan, Hamada M., Shalaby, Lobna, Shaltout, Inass, Sharara, Ala I., Sharma, Vishal, Shawa, Isaac Thom, Shawkat, Ahmed, Shawky, Nehal, Shehata, Osama, Sheils, Sinead, Shewaye, Abate Bane, Shi, Guojun, Shi, Junping, Shimose, Shigeo, Shirono, Tomotake, Shou, Lan, Shrestha, Ananta, Shui, Guanghou, Sievert, William, Sigurdardottir, Solveig, Sira, Mostafa Mohamed, Siradj, Riyadh, Sison, Cecilia, Smyth, Linda, Soliman, Reham, Sollano, Jose D, Sombie, Roger, Sonderup, Mark, Sood, Siddharth, Soriano, German, Stedman, Catherine A M, Stefanyuk, Oksana, Štimac, Davor, Strasser, Simone, Strnad, Pavel, Stuart, Katherine, Su, Wen, Su, Minghua, Sumida, Yoshio, Sumie, Shuji, Sun, Dan-Qin, Sun, Jing, Suzuki, Hiroyuki, Svegliati-Baroni, Gianluca, Swar, Mohamed Osman, TAHARBOUCHT, S., Taher, Zenab, Takamura, Saori, Tan, Lin, Tan, Soek-Siam, Tanwandee, Tawesak, Tarek, Sara, Tatiana, Ghelimici, Tavaglione, Federica, Tecson, Gina Y., Tee, Hoi-Poh, Teschke, Rolf, Tharwat, Mostafa, Thong, Vo Duy, Thursz, Mark, Tine, Tulari, Tiribelli, Claudio, Tolmane, Ieva, Tong, Jing, Tongo, Marco, Torkie, Mamdouh, Torre, Aldo, Torres, Esther A, Trajkovska, Meri, Treeprasertsuk, Sombat, Tsutsumi, Tsubasa, Tu, Thomas, Tur, Josep A., Turan, Dilara, Turcan, Svetlana, Turkina, Svetlana, Tutar, Engin, Tzeuton, Christian, Ugiagbe, Rose, Uygun, Ahmet, Vacca, Michele, Vajro, Pietro, Van der Poorten, David, Van Kleef, Laurens A., Vashakidze, Eliza, Velazquez, Carlos Moctezuma, Velazquez, Mirtha Infante, Vento, Sandro, Verhoeven, Veronique, Vespasiani-Gentilucci, Umberto, Vethakkan, Shireene Ratna, Vilaseca, Josep, Vítek, Libor, Volkanovska, Ance, Wallace, Michael, Wan, Wang, Wang, Yan, Wang, Ying, Wang, Xiaolin, Wang, Xuemei, Wang, Chengyan, Wang, Chunjiong, Wang, Mingjie, Wangchuk, Pelden, Weltman, Martin, White, MaryFrances, Wiegand, Johannes, Wifi, Mohamed-Naguib, Wigg, Alan, Wilhelmi, Markus, William, Remon, Wittenburg, Henning, Wu, Shengjie, Wubeneh, Abdu Mohammed, Xia, Hongping, Xiao, Jian, Xiao, Xiao, Xiaofeng, Wang, Xiong, Wanyuan, Xu, Liang, Xu, Jie, Xu, Weiguo, Xu, Jing-Hang, Xu, Keshu, Xu, Yumin, Xu, Shi-Hao, Xu, Meng, Xu, Aimin, Xu, Chengfu, Yan, Hongmei, Yang, Jingyi, Yang, Rui-Xu, Yang, Yating, Yang, Qinhe, Yang, Naibin, Yao, Jia, Yara, Justine, Yaraş, Serkan, Yılmaz, Nimet, Younes, Ramy, younes, Huda, Young, Sona, Youssef, Farah, Yu, Yanyan, Yu, Ming-Lung, Yuan, Jing, Yue, Zhang, Yuen, Man-Fung, Yun, Wang, Yurukova, Nonka, Zakaria, Serag, Zaky, Samy, Zaldastanishvili, Maia, Zapata, Rodrigo, Zare, Nazanin, Zerem, Enver, Zeriban, Nema, Zeshuai, Xu, Zhang, Huijie, Zhang, Xuemei, Zhang, Yupei, Zhang, Wen-Hua, Zhang, Xuchen, Zhang, Yon-ping, Zhang, Yuexin, Zhang, Zhan-qing, Zhao, Jingmin, Zhao, Rong-Rong, Zhao, Hongwei, Zheng, Chao, Zheng, Yijie, Zheng, Ruidan, Zheng, Tian-Lei, Zheng, Kenneth, Zhou, Xi Qiao, Zhou, Yongjian, Zhou, Yu-Jie, Zhou, Hong, Zhou, Ling, Zhou, Yongning, Zhu, Long dong, Zhu, Yong Fen, Zhu, Yueyong, Zhu, Pei-Wu, Ziada, Ebtesam, Ziring, David, Ziyi, Li, Zou, Shanshan, Zou, Zhengsheng, Zou, Huaibin, Zuart Ruiz, Roberto, Méndez-Sánchez, Nahum, Bugianesi, Elisabetta, Gish, Robert G, Lammert, Frank, Tilg, Herbert, Nguyen, Mindie H, Sarin, Shiv K, Fabrellas, Núria, Zelber-Sagi, Shira, Fan, Jian-Gao, Shiha, Gamal, Targher, Giovanni, Zheng, Ming-Hua, Chan, Wah-Kheong, Vinker, Shlomo, Kawaguchi, Takumi, Castera, Laurent, Yilmaz, Yusuf, Korenjak, Marko, Spearman, C Wendy, Ungan, Mehmet, Palmer, Melissa, El-Shabrawi, Mortada, Gruss, Hans-Juergen, Dufour, Jean-François, Dhawan, Anil, Wedemeyer, Heiner, George, Jacob, Valenti, Luca, Fouad, Yasser, Romero‐Gomez, Manuel, and Eslam, Mohammed

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2022
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30. Global multi-stakeholder endorsement of the MAFLD definition

Author

Méndez-Sánchez, Nahum, primary, Bugianesi, Elisabetta, additional, Gish, Robert G, additional, Lammert, Frank, additional, Tilg, Herbert, additional, Nguyen, Mindie H, additional, Sarin, Shiv K, additional, Fabrellas, Núria, additional, Zelber-Sagi, Shira, additional, Fan, Jian-Gao, additional, Shiha, Gamal, additional, Targher, Giovanni, additional, Zheng, Ming-Hua, additional, Chan, Wah-Kheong, additional, Vinker, Shlomo, additional, Kawaguchi, Takumi, additional, Castera, Laurent, additional, Yilmaz, Yusuf, additional, Korenjak, Marko, additional, Spearman, C Wendy, additional, Ungan, Mehmet, additional, Palmer, Melissa, additional, El-Shabrawi, Mortada, additional, Gruss, Hans-Juergen, additional, Dufour, Jean-François, additional, Dhawan, Anil, additional, Wedemeyer, Heiner, additional, George, Jacob, additional, Valenti, Luca, additional, Fouad, Yasser, additional, Romero‐Gomez, Manuel, additional, Eslam, Mohammed, additional, Abate, Maria Lorena, additional, Abbas, Bahaa, additional, Abbassy, Ahmed Amr, additional, Abd El Ghany, Waleed, additional, Abd Elkhalek, Amira, additional, Abd ElMajeed, Emad, additional, Abdalgaber, Mohammad, additional, AbdAllah, Mohamed, additional, Abdallah, Marwa, additional, Abdallah, Nourhan, additional, Abdelaleem, Shereen, additional, Abdelghani, Yasser, additional, Abdelghany, Wael, additional, Abdelhalim, Safaa Mohamed, additional, Abdelhamid, Wafaa, additional, Abdelhamid, Nehal, additional, Abdelkader, Nadia A., additional, Abdelkreem, Elsayed, additional, Abdelmohsen, Aly Mohamed, additional, Abdelrahman, Awny Ali, additional, Abd-elsalam, Sherief M, additional, Abdeltawab, Doaa, additional, Abduh, Abdulbaset, additional, Abdulhakam, Nada, additional, Abdulla, Maheeba, additional, Abedpoor, Navid, additional, Abenavoli, Ludovico, additional, Åberg, Fredrik, additional, Ablack, Omala, additional, Abo elftouh, Mostafa, additional, Abo-Amer, Yousry Esam-Eldin, additional, Aboubkr, Ashraf, additional, Aboud, Alaa, additional, Abouelnaga, Amr M., additional, Aboufarrag, Galal A., additional, Aboutaleb, Ashraf, additional, Abundis, Leticia, additional, Adalı, Gupse, additional, Adames, Enrique, additional, Adams, Leon, additional, Adda, Danjuma, additional, Adel, Noor, additional, Adel, Nada, additional, Adel Sayed, Muhammad, additional, Afaa, Taiba Jibril, additional, Afredj, Nawal, additional, Aghayeva, Gulnara, additional, Aghemo, Alessio, additional, Aguilar-Salinas, Carlos A., additional, Ahlenstiel, Golo, additional, Ahmady, Walid, additional, Ahmed, Wafaa, additional, Ahmed, Amira, additional, Ahmed, Samah Nasser, additional, Ahmed, Heba Mostafa, additional, Ahmed, Rasha, additional, Aigner, Elmar, additional, Akarsu, Mesut, additional, Akroush, Maisam, additional, Akyuz, Umit, additional, Al Mahtab, Mamun, additional, Al Qadiri, Tahani, additional, Al Rawahi, Yusriya, additional, AL rubaee, Razzaq, additional, Al Saffar, Muna, additional, Alam, Shahinul, additional, Al-Ani, Zaid, additional, Albillos, Agustín, additional, Alboraie, Mohamed, additional, Al-Busafi, Said, additional, Al-Emam, Mohamed, additional, Alharthi, Jawaher, additional, Ali, Kareem, additional, Ali, Basma Abdelmoez, additional, Ali, Mohammad, additional, Ali, Raja Affendi Raja, additional, Alisi, Anna, additional, AL-Khafaji, Ali Raad, additional, Alkhatry, Maryam, additional, Aller, Rocio, additional, Almansoury, Yahya, additional, Al-Naamani, Khalid, additional, Alnakeeb, Alaa, additional, Alonso, Anna, additional, Alqahtani, Saleh A., additional, Alrabadi, Leina, additional, Alswat, Khalid, additional, Altaher, Mahir, additional, Altamimi, Turki, additional, Altamirano, Jose, additional, Alvares-da-Silva, Mario R., additional, Aly, Elsragy Adel M., additional, Alzahaby, Amgad, additional, Alzamzamy, Ahmed, additional, Amano, Keisuke, additional, Amer, Maysa A., additional, Amin, Mona A., additional, Amin, Sayed A., additional, Amir, Ashraf A., additional, Ampuero, Javier, additional, Anas, Noha, additional, Andreone, Pietro, additional, Andriamandimby, Soa Fy, additional, Anees, Mahmoud, additional, Angela, Peltec, additional, Antonios, Manal, additional, Arafat, Wael, additional, Araya, Jose Moreno, additional, Armendariz-Borunda, Juan, additional, Armstrong, Matthew J., additional, Ashktorab, Hassan, additional, Aspichueta, Patricia, additional, Assal, Fathia, additional, Atef, Mira, additional, Attia, Dina, additional, Atwa, Hoda, additional, Awad, Reham, additional, Awad, Mohyeldeen Abd Elaziz, additional, Awny, Sally, additional, Awolowo, Obafemi, additional, Awuku, Yaw Asante, additional, Ayada, Ibrahim, additional, Aye, Than Than, additional, Ayman, Sherif, additional, Ayman, Hedy, additional, Ayoub, Hesham, additional, Azmy, Hosny M., additional, Babaran, Romiro P., additional, Badreldin, Omneya, additional, Badry, Ahmed, additional, Bahçecioğlu, İbrahim Halil, additional, Bahour, Amira, additional, Bai, Jiajia, additional, Balaban, Yasemin, additional, Balasubramanyam, Muthuswamy, additional, Bamakhrama, Khaled, additional, Banales, Jesus M, additional, Bangaru, Babu, additional, Bao, Jianfeng, additional, Barahona, Jorge Suazo, additional, Barakat, Salma, additional, Barbalho, Sandra Maria, additional, Barbra, Bikwa, additional, Barranco, Beatriz, additional, Barrera, Francisco, additional, Baumann, Ulrich, additional, Bazeed, Shamardan, additional, Bech, Eva, additional, Benayad, Aourarh, additional, Benesic, Andreas, additional, Bernstein, David, additional, Bessone, Fernando, additional, Birney, Susie, additional, Bisseye, Cyrille, additional, Blake, Martin, additional, Bobat, Bilal, additional, Bonfrate, Leonilde, additional, Bordin, Dmitry S, additional, Bosques-Padilla, Francisco, additional, Boursier, Jerome, additional, Boushab, Boushab Mohamed, additional, Bowen, David, additional, Bravo, Patricia Medina, additional, Brennan, Paul N, additional, Bright, Bisi, additional, Broekaert, Ilse, additional, Buque, Xabier, additional, Burgos-Santamaría, Diego, additional, Burman, Julio, additional, Busetto, Luca, additional, Byrne, Chris D., additional, Cabral-Prodigalidad, Patricia Anne I., additional, Cabrera-Alvarez, Guillermo, additional, Cai, Wei, additional, Cainelli, Francesca, additional, Caliskan, Ali Riza, additional, Canbay, Ali, additional, Cano-Contreras, Ana, additional, Cao, Hai-Xia, additional, Cao, Zhujun, additional, Carrion, Andres, additional, Carubbi, Francesca, additional, Casanovas, Teresa, additional, Castellanos Fernández, Marlen Ivón, additional, Chai, Jin, additional, Chan, Siew Pheng, additional, Charatcharoenwitthaya, Phunchai, additional, Chavez-Tapia, Norberto, additional, Chayama, Kazuaki, additional, Chen, Jinjun, additional, Chen, Lin, additional, Chen, Zhong-Wei, additional, Chen, Huiting, additional, Chen, Sui-Dan, additional, Chen, Qiang, additional, Chen, Yaxi, additional, Chen, Gang, additional, Chen, En-Quang, additional, Chen, Fei, additional, Chen, Pei-Jer, additional, Cheng, Robert, additional, Cheng, Wendy, additional, Chieh, Jack Tan Wei, additional, Chokr, Imad, additional, Cholongitas, Evangelos, additional, Choudhury, Ashok, additional, Chowdhury, Abhijit, additional, Chukwudike, Evaristus Sunday, additional, Ciardullo, Stefano, additional, Clayton, Michelle, additional, Clement, Karine, additional, Cloa, Marie Michelle, additional, Coccia, Cecilia, additional, Collazos, Cristina, additional, Colombo, Massimo, additional, Cosar, Arif Mansur, additional, Cotrim, Helma Pinchemel, additional, Couillerot, Joris, additional, Coulibaly, Alioune, additional, Crespo, Gonzalo, additional, Crespo, Javier, additional, Cruells, Maria, additional, Cua, Ian Homer Y., additional, Dabbous, Hesham K., additional, Dalekos, George N, additional, D'Alia, Patricia, additional, Dan, Li, additional, Dao, Viet Hang, additional, Darwish, Mostafa, additional, Datz, Christian, additional, Davalos-Moscol, Milagros B, additional, Dawoud, Heba, additional, de Careaga, Blanca Olaechea, additional, de Knegt, Robert, additional, de Ledinghen, Victor, additional, de Silva, Janaka, additional, Debzi, Nabil, additional, Decraecker, Marie, additional, Del Pozo, Elvira, additional, Delgado, Teresa C, additional, Delgado-Blanco, Manuel, additional, Dembiński, Łukasz, additional, Depina, Adilson, additional, Derbala, Moutaz, additional, Desalegn, Hailemichael, additional, Desbois-Mouthon, Christèle, additional, Desoky, Mahmoud, additional, Dev, Anouk, additional, Di Ciaula, Agostino, additional, Diago, Moisés, additional, Diallo, Ibrahima, additional, Díaz, Luis Antonio, additional, Dirchwolf, Melisa, additional, Dongiovanni, Paola, additional, Dorofeyev, Andrriy, additional, Dou, Xiaoguang, additional, Douglas, Mark W., additional, Doulberis, Michael, additional, Dovia, Cecil K., additional, Doyle, Adam, additional, Dragojević, Ivana, additional, Drenth, Joost PH, additional, Duan, Xuefei, additional, Dulskas, Audrius, additional, Dumitrascu, Dan L, additional, Duncan, Oliver, additional, Dusabejambo, Vincent, additional, Dwawhi, Rev. Shem N.A., additional, Eiketsu, Sho, additional, El Amrousy, Doaa, additional, El Deeb, Ahmed, additional, El Deriny, Ghada, additional, El Din, Hesham Salah, additional, El Kamshishy, Salwa, additional, El Kassas, Mohamed, additional, El Raziky, Maissa, additional, Elagamy, Osama A, additional, Elakel, Wafaa, additional, Elalfy, Dina, additional, Elaraby, Hanaa, additional, ElAwady, Heba, additional, Elbadawy, Reda, additional, Eldash, Hanaa Hassan, additional, Eldefrawy, Manal S., additional, Elecharri, Carol Lezama, additional, Elfaramawy, Amel, additional, Elfatih, Mohammed, additional, Elfiky, Mahmoud, additional, Elgamsy, Mohamed, additional, Elgendy, Mohamed, additional, El-Guindi, Mohamed A., additional, Elhussieny, Nagi, additional, Eliwa, Ahmed Maher, additional, Elkabbany, Zeineb, additional, El-Khayat, Hesham, additional, El-Koofy, Nehal M., additional, Elmetwalli, Alaa, additional, Elrabat, Amr, additional, El-Raey, Fathiya, additional, Elrashdy, Fatma, additional, Elsahhar, Medhat, additional, Elsaid, Esraa M., additional, Elsayed, Shimaa, additional, Elsayed, Hany, additional, Elsayed, Aly, additional, Elsayed, Amr M., additional, Elsayed, Hamdy, additional, El-Serafy, Magdy, additional, Elsharkawy, Ahmed M., additional, Elsheemy, Reem Yehia, additional, Elshemy, Eman Elsayed, additional, Elsherbini, Sara, additional, Eltoukhy, Naglaa, additional, Elwakil, Reda, additional, Emad, Ola, additional, Emad, Shaimaa, additional, Embabi, Mohamed, additional, Ergenç, Ilkay, additional, Ermolova, Tatiana, additional, Esmat, Gamal, additional, Esmat, Doaa M., additional, Estupiñan, Enrique Carrera, additional, Ettair, Said, additional, Eugen, Tcaciuc, additional, Ezz-Eldin, Mohammed, additional, Falcón, Lidia Patricia Valdivieso, additional, Fan, Yu-Chen, additional, Fandari, Samah, additional, Farag, Mahmoud, additional, Farahat, Taghreed Mohamed, additional, Fares, Eman M., additional, Fares, Michael, additional, Fassio, Eduardo, additional, Fathy, Hayam, additional, Fathy, Dina, additional, Fathy, Wael, additional, Fayed, Soheir, additional, Feng, Dan, additional, Feng, Gong, additional, Fernández-Bermejo, Miguel, additional, Ferreira, Cristina Targa, additional, Ferrer, Javier Díaz, additional, Forbes, Alastair, additional, Fouad, Rabab, additional, Fouad, Hanan M., additional, Frisch, Tove, additional, Fujii, Hideki, additional, Fukunaga, Shuhei, additional, Fukunishi, Shinya, additional, Fulya, Hacer, additional, Furuhashi, Masato, additional, Gaber, Yasmine, additional, Galang, Augusto Jose G., additional, Gallardo, Jacqueline Cordova, additional, Galloso, Rocío, additional, Gamal, Mahmoud, additional, Gamal, Reham, additional, Gamal, Hadeel, additional, Gan, Jian, additional, Ganbold, Anar, additional, Gao, Xin, additional, Garas, George, additional, Garba, Tony, additional, García-Cortes, Miren, additional, García-Monzón, Carmelo, additional, García-Samaniego, Javier, additional, Gastaldelli, Amalia, additional, Gatica, Manuel, additional, Gatley, Elizabeth, additional, Gegeshidze, Tamar, additional, Geng, Bin, additional, Ghazinyan, Hasmik, additional, Ghoneem, Salma, additional, Giacomelli, Luca, additional, Giannelli, Gianluigi, additional, Giannini, Edoardo G., additional, Giefer, Matthew, additional, Ginès, Pere, additional, Girala, Marcos, additional, Giraudi, Pablo J, additional, Goh, George Boon-Bee, additional, Gomaa, Ahmed Ali, additional, Gong, Benbingdi, additional, Gonzales, Dina Hilda C., additional, Gonzalez, Humberto C., additional, Gonzalez-Huezo, Maria Saraí, additional, Graupera, Isabel, additional, Grgurevic, Ivica, additional, Grønbæk, Henning, additional, Gu, Xuelian, additional, Guan, Lin, additional, Gueye, Ibrahima, additional, Guingané, Alice Nanelin, additional, Gul, Ozen Oz, additional, Gul, Cuma Bulent, additional, Guo, Qing, additional, Gupta, Pramendra Prasad, additional, Gurakar, Ahmet, additional, Gutierrez, Juan Carlos Restrepo, additional, Habib, Ghada, additional, Hafez, Azaa, additional, Hagman, Emilia, additional, Halawa, Eman, additional, Hamdy, Osama, additional, Hamed, Abd Elkhalek, additional, Hamed, Dina H., additional, Hamid, Saeed, additional, Hamoudi, Waseem, additional, Han, Yu, additional, Haridy, James, additional, Haridy, Hanan, additional, Harris, David C H Harris, additional, Hart, Michael, additional, Hasan, Fuad, additional, Hashim, Almoutaz, additional, Hassan, Israa, additional, Hassan, Ayman, additional, Hassan, Essam Ali, additional, Hassan, Adel Ahmed, additional, Hassan, Magda Shehata, additional, Hassanin, Fetouh, additional, Hassnine, Alshymaa, additional, Haukeland, John Willy, additional, Hawal, Amr Ismael M., additional, He, Jinfan, additional, He, Qiong, additional, He, Yong, additional, He, Fang-Ping, additional, Hegazy, Mona, additional, Hegazy, Adham, additional, Henegil, Osama, additional, Hernández, Nelia, additional, Hernández-Guerra, Manuel, additional, Higuera-de-la-Tijera, Fatima, additional, Hindy, Ibrahim, additional, Hirota, Keisuke, additional, Ho, Lee Chi, additional, Hodge, Alexander, additional, Hosny, Mohamed, additional, Hou, Xin, additional, Huang, Jiao-Feng, additional, Huang, Yan, additional, Huang, Zhifeng, additional, Huang, Yuan, additional, Huang, Ang, additional, Huang, Xiao-Ping, additional, Hui-ping, Sheng, additional, Hunyady, Bela, additional, Hussein, Mennatallah A., additional, Hussein, Osama, additional, Hussien, Shahinaz Mahmoud, additional, Ibáñez-Samaniego, Luis, additional, Ibdah, Jamal, additional, Ibrahim, Luqman, additional, Ibrahim, Miada, additional, Ibrahim, Ibrahim, additional, Icaza-Chávez, Maria E., additional, Idelbi, Sahar, additional, Idilman, Ramazan Idilman, additional, Ikeda, Mayumi, additional, Indolfi, Giuseppe, additional, Invernizzi, Federica, additional, Irshad, Iram, additional, Isa, Hasan Mohamed Ali, additional, Iskandar, Natacha Jreige, additional, Ismaiel, Abdulrahman, additional, Ismail, Mariam, additional, Ismail, Zulkifli, additional, Ismail, Faisal, additional, Iwamoto, Hideki, additional, Jack, Kathryn, additional, Jacob, Rachael, additional, Jafarov, Fuad, additional, Jafri, Wasim, additional, Jahshan, Helen, additional, Jalal, Prasun K, additional, Jancoriene, Ligita, additional, Janicko, Martin, additional, Jayasena, Hiruni, additional, Jefferies, Meryem, additional, Jha, Vivekanand, additional, Ji, Fanpu, additional, Ji, Yaqiu, additional, Jia, Jidong, additional, Jiang, Changtao, additional, Jiang, Ni, additional, Jiang, Zong-zhe, additional, Jin, Xing, additional, Jin, Yi, additional, Jing, Xu, additional, Jingyu, Qian, additional, Jinjolava, Maia, additional, Jong, FX Himawan Haryanto, additional, Jucov, Alina, additional, Julius, Ibecheole, additional, Kaddah, Mona, additional, Kamada, Yoshihiro, additional, kamal, Abobakr, additional, Kamal, Enas Mohamed, additional, Kamel, Ashraf Sayed, additional, Kao, Jia-Horng, additional, Karin, Maja, additional, Karlas, Thomas, additional, Kashwaa, Mohammad, additional, Katsidzira, Leolin, additional, Kaya, Eda, additional, Kayasseh, M.Azzam, additional, Keenan, Bernadette, additional, Keklikkiran, Caglayan, additional, Keml, William, additional, Khalaf, Deia K., additional, Khalefa, Rofida, additional, Khamis, Sherin, additional, Khater, Doaa, additional, khattab, Hamed, additional, Khavkin, Anatoly, additional, Khlynova, Olga, additional, Khmis, Nabil, additional, Kobyliak, Nazarii, additional, Koffas, Apostolos, additional, Koike, Kazuhiko, additional, Kok, Kenneth Y.Y., additional, Koller, Tomas, additional, Komas, Narcisse Patrice, additional, Korochanskaya, Nataliya V., additional, Koulla, Yannoula, additional, Koya, Shunji, additional, Kraft, Colleen, additional, Kraja, Bledar, additional, Krawczyk, Marcin, additional, Kuchay, Mohammad Shafi, additional, Kulkarni, Anand V, additional, Kumar, Ashish, additional, Kumar, Manoj, additional, Lakoh, Sulaiman, additional, Lam, Philip, additional, Lan, Ling, additional, Lange, Naomi F., additional, Lankarani, Kamran Bagheri, additional, Lanthier, Nicolas, additional, Lapshyna, Kateryna, additional, Lashen, Sameh A., additional, Laure, Konang Nguieguia Justine, additional, Lazebnik, Leonid, additional, Lebrec, Didier, additional, Lee, Samuel S., additional, Lee, Way Seah, additional, Lee, Yeong Yeh, additional, Leeming, Diana Julie, additional, Leite, Nathalie Carvalho, additional, Leon, Roberto, additional, Lesmana, Cosmas Rinaldi Adithya, additional, Li, Junfeng, additional, Li, Qiong, additional, Li, Jun, additional, Li, Yang-Yang, additional, Li, Yufang, additional, Li, Lei, additional, Li, Min, additional, li, Yiling, additional, Liang, Huiqing, additional, Lijuan, Tang, additional, Lim, Seng Gee, additional, Lim, Lee-Ling, additional, Lin, Shumei, additional, Lin, Han-Chieh, additional, Lin, Rita, additional, Lithy, Rania, additional, Liu, Yaru, additional, Liu, Yuanyuan, additional, Liu, Xin, additional, Liu, Wen-Yue, additional, Liu, Shourong, additional, Liu, Ken, additional, Liu, Tian, additional, Lonardo, Amedeo, additional, López, Mariana Bravo, additional, López-Benages, Eva, additional, Lopez-Jaramillo, Patricio, additional, Lu, Huimin, additional, Lu, Lun Gen, additional, Lu, Yan, additional, Lubel, John, additional, Lui, Rashid, additional, Lupasco, Iulianna, additional, Luzina, Elena, additional, Lv, Xiao-Hui, additional, Lynch, Kate, additional, Ma, Hong-Lei, additional, Machado, Mariana Verdelho, additional, Maduka, Nonso, additional, Madzharova, Katerina, additional, Magdaong, Russellini, additional, Mahadeva, Sanjiv, additional, Mahfouz, Amel, additional, Mahmood, Nik Ritza Kosai Nik, additional, Mahmoud, Eman, additional, Mahrous, Mohamed, additional, Maiwall, Rakhi, additional, Majeed, Ammar, additional, Majumdar, Avik, additional, Mak, Loey, additional, Maklouf, Madiha M, additional, Malekzadeh, Reza, additional, Mandato, Claudia, additional, Mangia, Alessandra, additional, Mann, Jake, additional, Mansour, Hala Hussien, additional, Mansouri, Abdellah, additional, Mantovani, Alessandro, additional, Mao, Jun qian, additional, Maramag, Flor, additional, Marchesini, Giulio, additional, Marcus, Claude, additional, Marinho, Rui António Rocha Tato, additional, Martinez-Chantar, Maria L, additional, Martins, Antonieta A. Soares, additional, Marwan, Rana, additional, Mason, Karen Frances, additional, Masoud, Ghadeer, additional, Massoud, Mohamed Naguib, additional, Matamoros, Maria Amalia, additional, Mateos, Rosa Martín, additional, Mawed, Asmaa, additional, Mbanya, Jean Claude, additional, Mbendi, Charles, additional, McColaugh, Lone, additional, McLeod, Duncan, additional, Medina, Juan Francisco Rivera, additional, Megahed, Ahmed, additional, Mehrez, Mai, additional, Memon, Iqbal, additional, Merat, Shahin, additional, Mercado, Randy, additional, Mesbah, Ahmed, additional, Meskini, Taoufik, additional, Metwally, Mayada, additional, Metwaly, Rasha, additional, Miao, Lei, additional, Micah, Eileen, additional, Miele, Luca, additional, Milivojevic, Vladimir, additional, Milovanovic, Tamara, additional, Mina, Yvonne L., additional, Mishkovik, Milan, additional, Mishriki, Amal, additional, Mitchell, Tim, additional, Mohamed, Alshaimaa, additional, Mohamed, Mona, additional, Mohamed, Sofain, additional, Mohammed, Shady, additional, Mohammed, Ahmed, additional, Mohan, Viswanathan, additional, Mohie, Sara, additional, Mokhtar, Aalaa, additional, Moniem, Reham, additional, Montilla, Mabel Segura, additional, Morales, Jose Antonio Orozco, additional, Morata, María María Sánchez, additional, Moreno-Planas, Jose Maria, additional, Morise, Silvia, additional, Mosaad, Sherif, additional, Moselhy, Mohamed, additional, Mostafa, Alaa Mohamed, additional, Mostafa, Ebraheem, additional, Mouane, Nezha, additional, Mousa, Nasser, additional, Moustafa, Hamdy Mahfouz, additional, Msherif, Abeer, additional, Muller, Kate, additional, Munoz, Christopher, additional, Muñoz-Urribarri, Ana Beatriz, additional, Murillo, Omar Alfaro, additional, Mustapha, Feisul Idzwan, additional, Muzurović, Emir, additional, Nabil, Yehia, additional, Nafady, Shaymaa, additional, Nagamatsu, Ayu, additional, Nakajima, Atsushi, additional, Nakano, Dan, additional, Nan, Yuemin, additional, Nascimbeni, Fabio, additional, Naseef, Mirella S., additional, Nashat, Nagwa, additional, Natalia, Taran, additional, Negro, Francesco, additional, Nersesov, Alexander V., additional, Neuman, Manuela, additional, Ng'wanasayi, Masolwa, additional, Ni, Yan, additional, Nicoll, Amanda, additional, Niizeki, Takashi, additional, Nikolova, Dafina, additional, Ningning, Wang, additional, Niriella, Madunil, additional, Nogoibaeva, K.A, additional, Nordien, Rozeena, additional, O Sullivan, Catherine, additional, O'Beirne, James, additional, Obekpa, Solomon, additional, Ocama, Ponsiano, additional, Ochwoto, Missiani, additional, Ogolodom, Michael Promise, additional, Ojo, Olusegun, additional, Okrostsvaridze, Nana, additional, Oliveira, Claudia P., additional, Omaña, Raul Contreras, additional, Omar, Omneya M., additional, Omar, Hanaa, additional, Omar, Mabroka, additional, Omran, Salma, additional, Omran, Reham, additional, Osman, Marian Muse, additional, Owise, Nevin, additional, Owusu-Ansah, Theobald, additional, Padilla- Machaca, P. Martín, additional, Palle, Sirish, additional, Pan, Ziyan, additional, Pan, Xiao-Yan, additional, Pan, Qiuwei, additional, Papaefthymiou, Apostolis, additional, Paquissi, Feliciano Chanana, additional, Par, Gabriella, additional, Parkash, Arit, additional, Payawal, Diana, additional, Peltekian, Kevork M., additional, Peng, Xuebin, additional, Peng, Liang, additional, Peng, Ying, additional, Pengoria, Rahul, additional, Perez, Martina, additional, Pérez, José Luis, additional, Pérez, Norma Marlene, additional, Persico, Marcello, additional, Pessoa, Mário Guimarães, additional, Petta, Salvatore, additional, Philip, Mathew, additional, Plaz Torres, Maria Corina, additional, Polavarapu, Naveen, additional, Poniachik, Jaime, additional, Portincasa, Piero, additional, Pu, Chunwen, additional, Pürnak, Tuğrul, additional, Purwanto, Edhie, additional, Qi, Xiaolong, additional, Qi, Xingshun, additional, Qian, Zibing, additional, Qiang, Zhao, additional, Qiao, Zengpei, additional, Qiao, Liang, additional, Queiroz, Alberto, additional, Rabiee, Atoosa, additional, Radwan, Manal, additional, Rahetilahy, Alain Marcel, additional, Ramadan, Yasmin, additional, Ramadan, Dina, additional, Ramli, Anis Safura, additional, Ramm, Grant A., additional, Ran, Ao, additional, Rankovic, Ivan, additional, RAO, Huiying, additional, Raouf, Sara, additional, Ray, Sayantan, additional, Reau, Nancy, additional, Refaat, Ahmed, additional, Reiberger, Thomas, additional, Remes-Troche, Jose M, additional, Reyes, Eira Cerda, additional, Richardson, Ben, additional, Ridruejo, Ezequiel, additional, Riestra Jimenez, Sergio, additional, Rizk, Ibrahim, additional, Roberts, Stuart, additional, Roblero, Juan Pablo, additional, Robles, Jorge Alberto Prado, additional, Rockey, Don, additional, Rodríguez, Manuel, additional, Rodríguez Hernández, Heriberto, additional, Román, Eva, additional, Romeiro, Fernando Gomes, additional, Romeo, Stefano, additional, Rosales-Zabal, Jose Miguel, additional, Roshdi, Georgina R., additional, Rosso, Natalia, additional, Ruf, Andres, additional, Ruiz, Patricia Cordero, additional, Runes, Nelia R., additional, Ruzzenente, Andrea, additional, Ryan, Marno, additional, Saad, Ahmed, additional, Sabbagh, Eman BE, additional, Sabbah, Meriam, additional, Saber, Shimaa, additional, Sabrey, Reham, additional, Sabry, Ramy, additional, Saeed, Maysaa Abdallah, additional, Said, Dina, additional, Said, Ebada M, additional, Sakr, Mohammad Amin, additional, Salah, Yara, additional, Salama, Rabab Maamoun, additional, Salama, Asmaa, additional, Saleh, Hussein, additional, Saleh, Ahmed, additional, Salem, Ahmed, additional, Salem, Ahmed Thabet, additional, Salifou, Alkassoum, additional, Salih, Aso Faeq, additional, Salman, Abdallah, additional, Samouda, Hanen, additional, Sanai, Faisal, additional, Sánchez-Ávila, Juan Francisco, additional, Sanker, Lakshumanan, additional, Sano, Tomoya, additional, Sanz, Miquel, additional, Saparbu, Tobokalova, additional, Sawhney, Rohit, additional, Sayed, Fatma, additional, Sayed, Sayed A., additional, Sayed, Ashraf Othman, additional, Sayed, Manar, additional, Sebastiani, Giada, additional, Secadas, Laura, additional, Sediqi, Khawaja Qamaruddin, additional, Seif, Sameh, additional, Semida, Nady, additional, Şenateş, Ebubekir, additional, Serban, Elena Daniela, additional, Serfaty, Lawrence, additional, Seto, Wai-Kay, additional, Sghaier, Ikram, additional, Sha, Min, additional, Shabaan, Hamada M., additional, Shalaby, Lobna, additional, Shaltout, Inass, additional, Sharara, Ala I., additional, Sharma, Vishal, additional, Shawa, Isaac Thom, additional, Shawkat, Ahmed, additional, Shawky, Nehal, additional, Shehata, Osama, additional, Sheils, Sinead, additional, Shewaye, Abate Bane, additional, Shi, Guojun, additional, Shi, Junping, additional, Shimose, Shigeo, additional, Shirono, Tomotake, additional, Shou, Lan, additional, Shrestha, Ananta, additional, Shui, Guanghou, additional, Sievert, William, additional, Sigurdardottir, Solveig, additional, Sira, Mostafa Mohamed, additional, Siradj, Riyadh, additional, Sison, Cecilia, additional, Smyth, Linda, additional, Soliman, Reham, additional, Sollano, Jose D, additional, Sombie, Roger, additional, Sonderup, Mark, additional, Sood, Siddharth, additional, Soriano, German, additional, Stedman, Catherine A M, additional, Stefanyuk, Oksana, additional, Štimac, Davor, additional, Strasser, Simone, additional, Strnad, Pavel, additional, Stuart, Katherine, additional, Su, Wen, additional, Su, Minghua, additional, Sumida, Yoshio, additional, Sumie, Shuji, additional, Sun, Dan-Qin, additional, Sun, Jing, additional, Suzuki, Hiroyuki, additional, Svegliati-Baroni, Gianluca, additional, Swar, Mohamed Osman, additional, TAHARBOUCHT, S., additional, Taher, Zenab, additional, Takamura, Saori, additional, Tan, Lin, additional, Tan, Soek-Siam, additional, Tanwandee, Tawesak, additional, Tarek, Sara, additional, Tatiana, Ghelimici, additional, Tavaglione, Federica, additional, Tecson, Gina Y., additional, Tee, Hoi-Poh, additional, Teschke, Rolf, additional, Tharwat, Mostafa, additional, Thong, Vo Duy, additional, Thursz, Mark, additional, Tine, Tulari, additional, Tiribelli, Claudio, additional, Tolmane, Ieva, additional, Tong, Jing, additional, Tongo, Marco, additional, Torkie, Mamdouh, additional, Torre, Aldo, additional, Torres, Esther A, additional, Trajkovska, Meri, additional, Treeprasertsuk, Sombat, additional, Tsutsumi, Tsubasa, additional, Tu, Thomas, additional, Tur, Josep A., additional, Turan, Dilara, additional, Turcan, Svetlana, additional, Turkina, Svetlana, additional, Tutar, Engin, additional, Tzeuton, Christian, additional, Ugiagbe, Rose, additional, Uygun, Ahmet, additional, Vacca, Michele, additional, Vajro, Pietro, additional, Van der Poorten, David, additional, Van Kleef, Laurens A., additional, Vashakidze, Eliza, additional, Velazquez, Carlos Moctezuma, additional, Velazquez, Mirtha Infante, additional, Vento, Sandro, additional, Verhoeven, Veronique, additional, Vespasiani-Gentilucci, Umberto, additional, Vethakkan, Shireene Ratna, additional, Vilaseca, Josep, additional, Vítek, Libor, additional, Volkanovska, Ance, additional, Wallace, Michael, additional, Wan, Wang, additional, Wang, Yan, additional, Wang, Ying, additional, Wang, Xiaolin, additional, Wang, Xuemei, additional, Wang, Chengyan, additional, Wang, Chunjiong, additional, Wang, Mingjie, additional, Wangchuk, Pelden, additional, Weltman, Martin, additional, White, MaryFrances, additional, Wiegand, Johannes, additional, Wifi, Mohamed-Naguib, additional, Wigg, Alan, additional, Wilhelmi, Markus, additional, William, Remon, additional, Wittenburg, Henning, additional, Wu, Shengjie, additional, Wubeneh, Abdu Mohammed, additional, Xia, Hongping, additional, Xiao, Jian, additional, Xiao, Xiao, additional, Xiaofeng, Wang, additional, Xiong, Wanyuan, additional, Xu, Liang, additional, Xu, Jie, additional, Xu, Weiguo, additional, Xu, Jing-Hang, additional, Xu, Keshu, additional, Xu, Yumin, additional, Xu, Shi-Hao, additional, Xu, Meng, additional, Xu, Aimin, additional, Xu, Chengfu, additional, Yan, Hongmei, additional, Yang, Jingyi, additional, Yang, Rui-Xu, additional, Yang, Yating, additional, Yang, Qinhe, additional, Yang, Naibin, additional, Yao, Jia, additional, Yara, Justine, additional, Yaraş, Serkan, additional, Yılmaz, Nimet, additional, Younes, Ramy, additional, younes, Huda, additional, Young, Sona, additional, Youssef, Farah, additional, Yu, Yanyan, additional, Yu, Ming-Lung, additional, Yuan, Jing, additional, Yue, Zhang, additional, Yuen, Man-Fung, additional, Yun, Wang, additional, Yurukova, Nonka, additional, Zakaria, Serag, additional, Zaky, Samy, additional, Zaldastanishvili, Maia, additional, Zapata, Rodrigo, additional, Zare, Nazanin, additional, Zerem, Enver, additional, Zeriban, Nema, additional, Zeshuai, Xu, additional, Zhang, Huijie, additional, Zhang, Xuemei, additional, Zhang, Yupei, additional, Zhang, Wen-Hua, additional, Zhang, Xuchen, additional, Zhang, Yon-ping, additional, Zhang, Yuexin, additional, Zhang, Zhan-qing, additional, Zhao, Jingmin, additional, Zhao, Rong-Rong, additional, Zhao, Hongwei, additional, Zheng, Chao, additional, Zheng, Yijie, additional, Zheng, Ruidan, additional, Zheng, Tian-Lei, additional, Zheng, Kenneth, additional, Zhou, Xi Qiao, additional, Zhou, Yongjian, additional, Zhou, Yu-Jie, additional, Zhou, Hong, additional, Zhou, Ling, additional, Zhou, Yongning, additional, Zhu, Long dong, additional, Zhu, Yong Fen, additional, Zhu, Yueyong, additional, Zhu, Pei-Wu, additional, Ziada, Ebtesam, additional, Ziring, David, additional, Ziyi, Li, additional, Zou, Shanshan, additional, Zou, Zhengsheng, additional, Zou, Huaibin, additional, and Zuart Ruiz, Roberto, additional

Published
2022
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32. THU-296 Identification and assessment of new circulating serological biomarkers for the evaluation of liver disease severity in MASLD patients

Author

Maya, Douglas, Gallego-Durán, Rocío, Ibañez-Samaniego, Luis, Aller, Rocío, Pericàs, Juan Manuel, Montero-Vallejo, Rocío, Payeras, Isabel, Fernández-Iglesias, Anabel, Infantes-Fontán, Rocío, Carnicero, Carmen, Dominguez, Inmaculada, Jiménez-Massip, Alba, Peña-Chilet, María, Gato-Zambrano, Sheila, Cubero, Francisco Javier, Gil-Gómez, Antonio, Munoz-Hernández, Rocío, Álvarez-Ossorio, Ángela Rojas, Arroyo-López, Victor, Sigüenza, Rebeca, Martínez, Sergio Muñoz, Dopazo, Joaquín, Gracia-Sancho, Jordi, Bañares, Rafael, Herrojo, Javier Ampuero, and Romero-Gómez, Manuel

Published
2024
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34. Hepatitis C eradication improves cognitive function in patients with or without cirrhosis: A prospective real‐life study

Author

Ibáñez‐Samaniego, Luis, primary, Rapado‐Castro, Marta, additional, Cabrero, Lucia, additional, Navarrete, Cristina, additional, García‐Mulas, Seila, additional, Ahumada, Adriana, additional, Marquez, Laura, additional, Pérez, Maria Dolores, additional, Rincon, Diego, additional, Bañares, Rafael, additional, and Garcia‐Martinez, Rita, additional

Published
2021
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35. Evolución cognitiva y calidad de vida tras la erradicación del virus de la hepatitis C - estudio ECOVIC

Author

Ibáñez Samaniego, Luis, Bañares Cañizares, Rafael, and García Martínez, Rita

Subjects
Gastroenterología y hepatología, Enfermedades infecciosas
Abstract

La infección crónica por el virus de la hepatitis C (VHC) altera el funcionamiento cognitivo de algunos pacientes asociándose a una disminución de la calidad de vida relacionada con la salud (CVRS) y del funcionamiento. El efecto que el VHC tiene sobre el cerebro obedece a mecanismos fisiopatológicos diferentes según la fase de la enfermedad. En la fase previa al desarrollo de cirrosis predomina un efecto directo del VHC sobre el cerebro mientras que, en la fase de cirrosis, la insuficiencia hepática causa la disfunción cerebral. Se desconoce la forma en que ambas alteraciones interaccionan entre sí en los pacientes con enfermedad hepática avanzada así como el efecto que la erradicación del VHC con los nuevos antivirales pudiera tener sobre la función cognitiva y sobre la CVRS. OBJETIVOS: 1. Describir la función cognitiva, el estado de ánimo, el funcionamiento y la CVRS de acuerdo con el grado de lesión hepática y su evolución tras la erradicación del virus. 2. Identificar los factores relacionados con la presencia de disfunción cognitiva en pacientes con infección por el VHC antes y después de la erradicación...

Published
2021

36. Hipertensión portal: recomendaciones de diagnóstico y tratamiento. Documento de consenso de la Asociación Española para el Estudio del Hígado (AEEH) y el Centro para la Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)

Author

Albillos, Agustín, Bañares, Rafael, Hernández-Gea, Virginia, Alvarado-Tapias, Edilmar, Ampuero, Javier, Baiges, Anna, Bellot, Pablo, Calleja, José Luis, Cárdena, Andrés, Catalina, María-Vega, Escorsell, Àngels, Fortea, José Ignacio, García-Pagan, Juan Carlos, Genescà, Juan, Hernández-Guerra, Manuel, Ibáñez-Samaniego, Luis, Lens, Sabela, Llop, Elba, Simon-Talero, Macarena, Martín-Mateos, Rosa, Pons, Mónica, Pose, Elisa, Puente, Angela, Reverter, Enric, Rincón, Diego, Rodríguez-Gandía, Miguel Ángel, Téllez, Luis, Turón, Fanny, and Villanueva, Cándido

Abstract

La hipertensión portal es una anomalía hemodinámica que complica el curso de la cirrosis, así como de otras enfermedades que afectan a la circulación venosa portal. El desarrollo de hipertensión portal grava negativamente el pronóstico, especialmente cuando asciende por encima de una determinada cuantía conocida como hipertensión portal clínicamente significativa (HPCS). En la conferencia de consenso en hipertensión portal promovida por la Asociación Española para el Estudio del Hígado y el área de enfermedades hepáticas y digestivas del Centro de Investigación Biomédica en Red (CIBERehd) se han discutido diferentes aspectos del diagnóstico y del tratamiento de la hipertensión portal causada por la cirrosis o por enfermedades diferentes a esta. El resultado de esta discusión fue la redacción de un conjunto de recomendaciones que alcanzaron diferentes grados de consenso entre los panelistas y que se han plasmado en el presente documento de consenso. Las 6 áreas objeto de la discusión han sido: la relevancia de la HPCS y los métodos no invasivos utilizados para su diagnóstico y el de la cirrosis, la prevención del primer episodio de descompensación y de su recurrencia, el tratamiento de la hemorragia aguda por varices y de otras complicaciones de la hipertensión portal, las indicaciones del uso del TIPS y, por último, el diagnóstico y el tratamiento de las enfermedades vasculares del hígado.

Published
2025
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37. Evolución cognitiva y calidad de vida tras la erradicación del virus de la hepatitis C - estudio ECOVIC

Author

Bañares Cañizares, Rafael, García Martínez, Rita, Ibáñez Samaniego, Luis, Bañares Cañizares, Rafael, García Martínez, Rita, and Ibáñez Samaniego, Luis

Abstract

La infección crónica por el virus de la hepatitis C (VHC) altera el funcionamiento cognitivo de algunos pacientes asociándose a una disminución de la calidad de vida relacionada con la salud (CVRS) y del funcionamiento. El efecto que el VHC tiene sobre el cerebro obedece a mecanismos fisiopatológicos diferentes según la fase de la enfermedad. En la fase previa al desarrollo de cirrosis predomina un efecto directo del VHC sobre el cerebro mientras que, en la fase de cirrosis, la insuficiencia hepática causa la disfunción cerebral. Se desconoce la forma en que ambas alteraciones interaccionan entre sí en los pacientes con enfermedad hepática avanzada así como el efecto que la erradicación del VHC con los nuevos antivirales pudiera tener sobre la función cognitiva y sobre la CVRS. OBJETIVOS: 1. Describir la función cognitiva, el estado de ánimo, el funcionamiento y la CVRS de acuerdo con el grado de lesión hepática y su evolución tras la erradicación del virus. 2. Identificar los factores relacionados con la presencia de disfunción cognitiva en pacientes con infección por el VHC antes y después de la erradicación..., Chronic hepatitis C virus (HCV) infection influences cognitive function in some patients which is associated with a decrease in health-related quality of life (HRQoL) and functioning. According to the stage of liver disease, two different pathophysiological mechanisms are involved in cognitive impairment (CI). Before the development of cirrhosis, a direct neuropathic effect of the HCV prevails, while in the cirrhotic stage liver failure is the main driver of cognitive dysfunction. The way that both mechanisms interplay in patients with advanced liver disease is unknown, as well as the effect that viral eradication with the new direct antiviral agents (DAA) may have on cognitive function and HRQoL. ENDPOINTS: 1. To describe cognitive function, mood, functioning and HRQoL according to the stage of liver disease at baseline and after viral eradication. 2. To identify characteristics related to the presence of CI at baseline and after HCV eradication...

Published
2021

38. Bacterial infections in patients with acute variceal bleeding in the era of antibiotic prophylaxis

Author

Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Generalitat de Catalunya, European Commission, Martínez, Javier, Hernández-Gea, Virginia, Rodríguez-de-Santiago, Enrique, Téllez, Luis, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibáñez-Samaniego, Luis, Silva-Junior, Gilberto, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Bañares, Rafael, Krag, Aleksander, Llop, Elba, Laleman, Wim, Palazón, Jose María, Castellote, José, Rodrigues, Susana, Gluud, Lise L., Noronha-Ferreira, Carlos, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Schwarzer, Remy, Mundi, José Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Nevens, Frederik, Calleja, José Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, María Vega, Rudler, Marika, Alvarado, Edilmar, Pérez-Campuzano, Valeria, Guardascione, Maria Anna, Fischer, Petra, Bosch, Jaime, García-Pagán, Juan Carlos, Albillos, Agustín, Ministerio de Ciencia e Innovación (España), Instituto de Salud Carlos III, Generalitat de Catalunya, European Commission, Martínez, Javier, Hernández-Gea, Virginia, Rodríguez-de-Santiago, Enrique, Téllez, Luis, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibáñez-Samaniego, Luis, Silva-Junior, Gilberto, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Bañares, Rafael, Krag, Aleksander, Llop, Elba, Laleman, Wim, Palazón, Jose María, Castellote, José, Rodrigues, Susana, Gluud, Lise L., Noronha-Ferreira, Carlos, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Schwarzer, Remy, Mundi, José Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell'Era, Alessandra, Senzolo, Marco, Abraldes, Juan G., Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Nevens, Frederik, Calleja, José Luis, Jansen, Christian, Robic, Marie Angèle, Conejo, Irene, Catalina, María Vega, Rudler, Marika, Alvarado, Edilmar, Pérez-Campuzano, Valeria, Guardascione, Maria Anna, Fischer, Petra, Bosch, Jaime, García-Pagán, Juan Carlos, and Albillos, Agustín

Abstract

[Background & Aims] Antibiotic prophylaxis reduces the risk of infection and mortality in patients with cirrhosis and acute variceal bleeding (AVB). This study examines the incidence of, and risk factors for, bacterial infections during hospitalization in patients with AVB on antibiotic prophylaxis., [Methods] A post hoc analysis was performed using the database of an international, multicenter, observational study designed to examine the role of pre-emptive transjugular intrahepatic portosystemic shunts in patients with cirrhosis and AVB. Data were collected on patients with cirrhosis hospitalized for AVB (n = 2,138) from a prospective cohort (October 2013-May 2015) at 34 referral centers, and a retrospective cohort (October 2011-September 2013) at 19 of these centers. The primary outcome was incidence of bacterial infection during hospitalization., [Results] A total of 1,656 patients out of 1,770 (93.6%) received antibiotic prophylaxis; third-generation cephalosporins (76.2%) and quinolones (19.0%) were used most frequently. Of the patients on antibiotic prophylaxis, 320 patients developed bacterial infection during hospitalization. Respiratory infection accounted for 43.6% of infections and for 49.7% of infected patients, and occurred early after admission (median 3 days, IQR 1-6). On multivariate analysis, respiratory infection was independently associated with Child-Pugh C (odds ratio [OR] 3.1; 95% CI 1.4-6.7), grade III-IV encephalopathy (OR 2.8; 95% CI 1.8-4.4), orotracheal intubation for endoscopy (OR 2.6; 95% CI 1.8-3.8), nasogastric tube placement (OR 1.7; 95% CI 1.2-2.4) or esophageal balloon tamponade (OR 2.4; 95% CI 1.2-4.9)., [Conclusion] Bacterial infections develop in almost one-fifth of patients with AVB despite antibiotic prophylaxis. Respiratory infection is the most frequent, is an early event after admission, and is associated with advanced liver failure, severe hepatic encephalopathy and use of nasogastric tube, orotracheal intubation for endoscopy or esophageal balloon tamponade.

Published
2021

40. Elevation of Liver Fibrosis Index FIB-4 Is Associated With Poor Clinical Outcomes in Patients With COVID-19

Author

Ibáñez-Samaniego, Luis, primary, Bighelli, Federico, additional, Usón, Clara, additional, Caravaca, Celia, additional, Fernández Carrillo, Carlos, additional, Romero, Miriam, additional, Barreales, Mónica, additional, Perelló, Christie, additional, Madejón, Antonio, additional, Marcos, Aránzazu Caballero, additional, Albillos, Agustín, additional, Fernández, Inmaculada, additional, García-Samaniego, Javier, additional, Calleja, José Luis, additional, and Bañares, Rafael, additional

Published
2020
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41. Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS

Author

Universidad de Sevilla. Departamento de Medicina, CAPES Foundation, Ministry of Education of Brazil, Brasilia, Brazil, Cellex Foundation (PREDICT), China Scholarships Council, Deutsche Forschungsgemeinschaft, Ernst und Berta Grimmke Stiftung, European Union, Instituto de Salud Carlos III, Ministerio de Educacion y Ciencia, Rio Hortega Fellowship grant form Instituto de Salud Carlos III, Trebicka, Jonel, Gu, Wenyi, Ibáñez-Samaniego, Luis, Hernández-Gea, Virginia, Pitarch, Carla, Garcia, Elisabet, Romero Gómez, Manuel, Bañares, Rafael, Universidad de Sevilla. Departamento de Medicina, CAPES Foundation, Ministry of Education of Brazil, Brasilia, Brazil, Cellex Foundation (PREDICT), China Scholarships Council, Deutsche Forschungsgemeinschaft, Ernst und Berta Grimmke Stiftung, European Union, Instituto de Salud Carlos III, Ministerio de Educacion y Ciencia, Rio Hortega Fellowship grant form Instituto de Salud Carlos III, Trebicka, Jonel, Gu, Wenyi, Ibáñez-Samaniego, Luis, Hernández-Gea, Virginia, Pitarch, Carla, Garcia, Elisabet, Romero Gómez, Manuel, and Bañares, Rafael

Abstract

Background & Aims: The relationship between acute-on-chronic liver failure (ACLF) and acute variceal bleeding (AVB) is poorly understood. Specifically, the prevalence and prognosis of ACLF in the context of AVB is unclear, while the role of trans-jugular intrahepatic portosystemic shunt (TIPS) in the management in patients with ACLF has not been described to date. Methods: A multicenter, international, observational study was conducted in 2,138 patients from 34 centers between 2011 and 2015. ACLF was defined and graded according to the EASL-CLIF consortium definition. Placement of pre-emptive TIPS (pTIPS) was based on individual center policy. Patients were followed-up for 1 year, until death or liver transplantation. Cox regression and competing risk models (Gray's test) were used to identify independent predictors of rebleeding or mortality. Results: At admission, 380/2,138 (17.8%) patients had ACLF according to EASL-CLIF criteria (grade 1: 38.7%; grade 2: 39.2%; grade 3: 22.1%). The 42-day rebleeding (19% vs. 10%; p<0.001) and mortality (47% vs. 10%; p<0.001) rates were higher in patients with ACLF and increased with ACLF grades. Of note, the presence of ACLF was independently associated with rebleeding and mortality. pTIPS placement improved survival in patients with ACLF at 42 days and 1 year. This effect was also observed in propensity score matching analysis of 66 patients with ACLF, of whom 44 received pTIPs and 22 did not. Conclusions: This large multicenter international real-life study identified ACLF at admission as an independent predictor of rebleeding and mortality inpatients with AVB. Moreover, pTIPS was associated with improved survival in patients with ACLF and AVB. Lay summary: Acute variceal bleeding is a deadly complication of liver cirrhosis that results from severe portal hypertension. This study demonstrates that the presence of acute-on-chronic liver failure (ACLF) is the strongest predictor of mortality in patients with acute variceal bleed

Published
2020

42. Hepatitis C eradication improves cognitive function in patients with or without cirrhosis: A prospective real‐life study.

Author

Ibáñez‐Samaniego, Luis, Rapado‐Castro, Marta, Cabrero, Lucia, Navarrete, Cristina, García‐Mulas, Seila, Ahumada, Adriana, Marquez, Laura, Pérez, Maria Dolores, Rincon, Diego, Bañares, Rafael, and Garcia‐Martinez, Rita

Subjects
*HEPATITIS C, *COGNITIVE ability, *OLDER patients, *CIRRHOSIS of the liver, *HEPATITIS C virus
Abstract

Background and purpose: Hepatitis C virus (HCV) infection is associated with neuropsychiatric disturbances that impact on functioning and health‐related quality of life (HRQoL). Reversibility at different liver disease stages is unknown, particularly in cirrhosis. We aimed to evaluate cognition, functioning, and HRQoL following HCV eradication at different liver disease stages. Methods: A random sample (n = 152) of consecutive patients treated with direct‐acting antiviral agents (DAAs) between April 2015 and March 2017 were included. A comprehensive neuropsychological assessment, functioning and HRQoL questionnaires were applied at baseline, and 12 and 48 weeks after the end of antivirals. Results: One‐hundred thirty‐five patients who achieved virological response completed the follow‐up, of whom 44 had cirrhosis (27% decompensated). Twenty‐one percent had cognitive impairment before starting DAAs (34.1% cirrhotic vs. 14.4% noncirrhotic, p < 0.011). Viral eradication was associated with a decrease in cognitive impairment to 23% of cirrhotic and 6% of noncirrhotic patients (p < 0.05). Interestingly, older patients (B = 0.11, 95% confidence interval [CI] = 0.03–0.19) with baseline cognitive impairment (B = 3.58, 95% CI = 1.54–5.62) were those with higher cognitive benefit, regardless of liver disease. Persistent cognitive impairment was associated with having higher cardiovascular risk, cirrhosis, lower education, and higher anxiety and depression scores. Functioning and HRQoL also improved after eradication but remained worse in the cirrhotic group. Conclusions: Viral eradication decreases the prevalence of cognitive impairment and improves functioning and HRQoL. Patients with lower brain reserve (older patients) and baseline cognitive impairment may benefit the most. Identification and treatment of HCV patients through screening programs may reduce the burden of cognitive disturbances beyond the prevention of liver disease progression. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Clinical Utility of a Risk‐Adapted Protocol for the Evaluation of Coronary Artery Disease in Liver Transplant Recipients

Author

Romero‐Cristóbal, Mario, primary, Mombiela, Teresa, additional, Caballero, Aranzazu, additional, Clemente, Ana, additional, Fernández‐Yunquera, Ainhoa, additional, Diaz‐Fontenla, Fernando, additional, Rincón, Diego, additional, Ripoll, Cristina, additional, Bermejo, Javier, additional, Catalina, María‐Vega, additional, Matilla, Ana‐María, additional, Ibáñez‐Samaniego, Luis, additional, Pérez‐Peña, José, additional, López‐Baena, José‐Ángel, additional, Díaz‐Zorita, Benjamín, additional, Fernández‐Avilés, Francisco, additional, Salcedo, M. Magdalena, additional, and Bañares, Rafael, additional

Published
2019
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44. Meta-analysis of individual patient data of albumin dialysis in acute-on-chronic liver failure:focus on treatment intensity

Author

Bañares, Rafael, Ibáñez-Samaniego, Luis, Torner, Josep María, Pavesi, Marco, Olmedo, Carmen, Catalina, María Vega, Albillos, Agustín, Larsen, Fin Stolze, Nevens, Frederik, Hassanein, Tarek, Schmidt, Harmuth, Heeman, Uwe, Jalan, Rajiv, Moreau, Richard, Arroyo, Vicente, Bañares, Rafael, Ibáñez-Samaniego, Luis, Torner, Josep María, Pavesi, Marco, Olmedo, Carmen, Catalina, María Vega, Albillos, Agustín, Larsen, Fin Stolze, Nevens, Frederik, Hassanein, Tarek, Schmidt, Harmuth, Heeman, Uwe, Jalan, Rajiv, Moreau, Richard, and Arroyo, Vicente

Published
2019

45. Meta-analysis of individual patient data of albumin dialysis in acute-on-chronic liver failure: focus on treatment intensity

Author

Bañares, Rafael, primary, Ibáñez-Samaniego, Luis, additional, Torner, Josep María, additional, Pavesi, Marco, additional, Olmedo, Carmen, additional, Catalina, María Vega, additional, Albillos, Agustín, additional, Larsen, Fin Stolze, additional, Nevens, Frederik, additional, Hassanein, Tarek, additional, Schmidt, Harmuth, additional, Heeman, Uwe, additional, Jalan, Rajiv, additional, Moreau, Richard, additional, and Arroyo, Vicente, additional

Published
2019
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46. Plasma metabolomic fingerprint of advanced cirrhosis stages among HIV/HCV‐coinfected and HCV‐monoinfected patients.

Author

Salgüero, Sergio, Rojo, David, Berenguer, Juan, González‐García, Juan, Fernández‐Rodríguez, Amanda, Brochado‐Kith, Oscar, Díez, Cristina, Hontañon, Victor, Virseda‐Berdices, Ana, Martínez, Javier, Ibañez‐Samaniego, Luis, Llop‐Herrera, Elba, Barbas, Coral, Resino, Salvador, Jiménez‐Sousa, María A., Ibáñez‐Samaniego, Luis, Pérez‐Latorre, Leire, Rincón, Diego, Aldámiz‐Echevarría, Teresa, and Catalina, Vega

Subjects
SULFUR amino acids, LIQUID chromatography-mass spectrometry, KREBS cycle, CIRRHOSIS of the liver, BACTERIAL metabolites
Abstract

Background & Aims: Hepatitis C virus (HCV), human immunodeficiency virus (HIV) and cirrhosis induce metabolic disorders. Here, we aimed to evaluate the association of plasma metabolites with Child‐Turcotte‐Pugh (CTP) score and hepatic decompensation in HIV/HCV‐coinfected and HCV‐monoinfected patients with advanced cirrhosis. Methods: A cross‐sectional study was carried out in 62 HIV/HCV‐coinfected and 28 HCV‐monoinfected patients. Metabolomics analysis was performed by gas chromatography‐mass spectrometry (GC‐MS) and liquid chromatography‐mass spectrometry (LC‐MS). The statistical association analysis was performed by partial least squares discriminant analysis (PLS‐DA) and generalized linear model (GLM) with binomial distribution (to analyse HIV coinfection, high alcohol intake, treatment with statins, previous HCV therapy failure and decompensation) and ordinal logistic regression (OLR) models to analyse different stages of cirrhosis (CTP score). Results: The statistical analysis identified plasma metabolites associated with HIV coinfection, high alcohol intake, CTP score and hepatic decompensation. Overall, fatty acids, bile acids, aromatic and sulphur amino acids, butyrate derivatives, oxidized phospholipids, energy‐related metabolites and bacterial fermentation‐related metabolites were increased in more advanced cirrhosis stages; while lysophosphatidylcholines and lysophosphatidylethanolamines, branched‐chain amino acids (BCAA) and metabolites of tricarboxylic acid cycle, among others, were decreased in more advanced cirrhosis. Most of the significant metabolites displayed a similar trend after stratifying for HIV/HCV‐ and HCV‐infected patients. Glycolic acid, LPC (16:0) and taurocholic acid had high accuracy for discriminating patients according to decompensated cirrhosis (CTP ≥ 7). Conclusion: Altered plasma metabolomic profile was associated with advanced stages of cirrhosis in HIV/HCV‐coinfected and HCV‐monoinfected patients. [ABSTRACT FROM AUTHOR]

Published
2020
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48. 551 OPTIMAL TIMING OF ENDOSCOPY IS ASSOCIATED WITH LOWER 42-DAY MORTALITY IN VARICEAL BLEEDING

Author

Laursen, Stig B., Stanley, Adrian J., Hernandez-Gea, Virginia, Procopet, Bogdan, Giráldez, Alvaro, Sanchez, Cándido V., Thabut, Dominique, Ibañez-Samaniego, Luís, Martinez, Javier, Genesca, Joan, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, Jose M., Castellote, Jose, Rodrigues, Susana, Gluud, Lise L., Ferreira, Carlos Noronha, Barceló, Rafael, Cañete, Nuria, Rodriguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose L., Grønbæk, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dellera, Alessandra, Senzolo, Marco, Abraldes, Juan, Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Nevens, Frederik, Jansen, Christian, Robic, Marie A., Conejo, Irene, Catalina, María-Vega, Albillos, Agustin, Rudler, Marika, Alvarado, Edilmar A., Guardascione, Maria A., Tantau, Marcel, Bosch, Jaime, Torres, Ferran, Garcia-Pagán, Juan C., and Krag, Aleksander

Published
2019
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49. PS-022-Optimal timing of endoscopy is associated with lower 42-day mortality in variceal bleeding

Author

Laursen, Stig Borbjerg, Stanley, Adrian, Hernandez-Gea, Virginia, Procopet, Bogdan, Giráldez, Álvaro, Amitrano, Lucio, Villanueva, Candid, Thabut, Dominique, Ibañez-Samaniego, Luis, Silva-Junior, Gilberto, Martinez, Javier, Genescà, Joan, Bureau, Christophe, Trebicka, Jonel, Llop, Elba, Laleman, Wim, Palazon, Jm, Castellote, Jose, Rodrigues, Susana, Gluud, Lise L, Ferreira, Carlos Noronha, Barcelo, Rafael, Cañete, Nuria, Rodríguez, Manuel, Ferlitsch, Arnulf, Mundi, Jose Luis, Gronbaek, Henning, Hernández-Guerra, Manuel, Sassatelli, Romano, Dell’Era, Alessandra, Senzolo, Marco, Abraldes, Juan G, Romero-Gómez, Manuel, Zipprich, Alexander, Casas, Meritxell, Masnou, Helena, Primignani, Massimo, Nevens, Frederik, Calleja, Jose Luis, Jansen, Christian, Robic, Marie Angele, Conejo, Irene, Catalina, Maria-Vega, Albillos, Agustin, Rudler, Marika, Alvarado, Edilmar, Guardascione, Maria Anna, Tantau, Marcel, Bosch, Jaime, Torres, Ferran, Garcia-Pagán, Juan Carlos, and Krag, Aleksander

Published
2019
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