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Background and Aims: Chronic kidney disease (CKD) patients undergoing peritoneal dialysis (PD) are susceptible to complications, including iron overload, which can significantly impact their prognosis and overall health. This scoping review aimed to study the prevalence and implications of iron overload in CKD patients undergoing PD. Methods: A comprehensive search was conducted across five databases, leading to the selection of 18 papers for in‐depth analysis. These studies collectively involved 381 PD patients, 60.3% were males. Results: No consensus was reached regarding the exact diagnostic cutoff for iron overload. The investigations revealed four main aspects: (1) Seven papers identified various factors contributing to iron overload, emphasizing the role of different iron supplements and magnetic resonance imaging's capability to diagnose iron accumulation in organs; (2) Iron overload in young patients was found to hinder growth; (3) Six studies highlighted the adverse effects of iron overload, with cardiac issues being the most significant; (4) Three studies demonstrated the efficacy of iron‐chelating agents, Deferoxamine and Deferasirox, in treating iron overload patients undergoing PD. Overall, the estimated prevalence of liver iron overload in CKD patients on PD ranges from approximately 10% to 28.6%, which is far lower than the prevalence of 75% elegantly shown in HD patients. Conclusion: While iron overload was a significant concern for CKD patients undergoing PD in the past, it is less common in the current era due to advancements in treatments, such as erythropoiesis‐stimulating agents. Treatment with specific chelation agents has proven beneficial, but there is also a risk of adverse effects, necessitating meticulous monitoring and timely intervention. [ABSTRACT FROM AUTHOR]

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The analysis of PCR products of immunological and antioxidant gene in liver and lung tissue of mice showed high sensitivity and specificity in detecting genes. An amplicon corresponding to Product size 185 bp, 330bp, 222bp, 500bp, 185bp, 345bp and 264bp wear seen after agarose gel electrophoresis PCR was tested with three different concentrations (75, 150, 200 µg/ml). In liver and lung showed that the genomic DNA of samples were recognized and complementary to IL-6, IL-2, bax F, cmyc, p53, rasp-21 and g3pdh gene sequence alignment using BLAST and BioEdit showed Transvers substitution in IL-6, c-myc, rasp-21 and g3pdh with accession number : JN98643.1, JF76532.1, UI23457.1 and JO96356.1 respectively 100% compatibility with NCBI, score 2026 and expect 0.0 and Transition substitution in IL-2, bax F and rasp-21 gene all the information about the types of mutations detected in partial liver tissue gene using immunological and antioxidant primer after exposure to gliotoxin. There are transversion substitution in the genes of lung IL-6, IL-2, bax F, c-myc, p53 and g3pdh with Sequence IDLN998078.1, KM340988.1, KS576160.1, QS094532.1, YM547899.1, respectively. In conclusion, Transition substitution in LM092240.1 IL-2 gene with Sequence IDJH279509.1 location at Range of nucleotide from 8 to 3936 compared with data obtained from Gene Bank. [ABSTRACT FROM AUTHOR]

Copyright of Alustath is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)