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3. Analysis of data obtained with Au ions of 700 MeV/n energy in an allene-doped liquid Ar homogeneous calorimeter

Author

Ichige, M., primary, Ben, S., additional, Crawford, H.J., additional, Doke, T., additional, Engelage, J.M., additional, Flores, I., additional, Greiner, L., additional, Hayashi, T., additional, Kashiwagi, T., additional, Kikuchi, J., additional, Kobayashi, M., additional, Masuda, K., additional, Mozumder, A., additional, Mitchell, J.W., additional, Shibamura, E., additional, Takashima, T., additional, and Tull, C.E., additional

Published
1995
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4. Measurement of attenuation length of scintillation light in liquid xenon

Author

Ishida, N., primary, Doke, T., additional, Kikuchi, J., additional, Kuwahara, K., additional, Kashiwagi, T., additional, Ichige, M., additional, Hasuike, K., additional, Ito, K., additional, Ben, S., additional, Hitachi, A., additional, Qu, Y.H., additional, Masuda, K., additional, Suzuki, M., additional, Kase, M., additional, Takahashi, T., additional, Chen, M., additional, Sumorok, S., additional, Gaudreau, M., additional, and Aprile, E., additional

Published
1993
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6. A novel self-aligned shallow trench isolation cell for 90 nm 4 Gbit NAND flash EEPROMs

Author

Ichige, M., primary, Takeuchi, Y., additional, Sugimae, K., additional, Sato, A., additional, Matsui, M., additional, Kamigaichi, T., additional, Kutsukake, H., additional, Ishibashi, Y., additional, Saito, M., additional, Mori, S., additional, Meguro, H., additional, Miyazaki, S., additional, Miwa, T., additional, Takahashi, S., additional, Iguchi, T., additional, Kawai, N., additional, Tamon, S., additional, Arai, N., additional, Kamata, H., additional, Minami, T., additional, Iizuka, H., additional, Higashitani, M., additional, Pham, T., additional, Hemink, G., additional, Momodomi, M., additional, and Shirota, R., additional

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9. Novel isoflavone glucosides in groundnut (Apios americana Medik) and their antiandrogenic activities.

Author

Ichige M, Fukuda E, Miida S, Hattan J, Misawa N, Saito S, Fujimaki T, Imoto M, and Shindo K

Subjects
Androgen Antagonists chemistry, Androgen Receptor Antagonists, Cell Line, Tumor, Gene Expression drug effects, Glucosides chemistry, Humans, Isoflavones chemistry, Magnetic Resonance Spectroscopy, Male, Molecular Structure, Prostate-Specific Antigen genetics, Prostatic Neoplasms metabolism, Spectrometry, Mass, Electrospray Ionization, Androgen Antagonists pharmacology, Arachis chemistry, Glucosides isolation & purification, Glucosides pharmacology, Isoflavones isolation & purification, Isoflavones pharmacology
Abstract

Isoflavone glucosides (2'-hydroxy,5-methoxy genistein-7-O-glucoside (1), 2'-hydroxy genistein-7-O-gentibioside (2), 5-methoxy genistein-7-O-glucoside (3), 3',5-dimethoxy genistein-7-O-glucoside (4), 2'-hydroxy genistein-7-O-glucoside (5), genistein-7-O-gentibioside (6), 2'-hydroxy,5-methoxy genistein-4',7-O-diglucoside (7), and 2'-hydroxy genistein-4',7-O-diglucoside (8)) were isolated from the groundnut of Apios americana Medik. Their structures were elucidated on the basis of HR-ESI-MS and 1D- and 2D-NMR analyses. Compounds 1, 2, 4, and 7 are new compounds presented here for the first time. Compounds 2 and 5 were proven to be androgen receptor antagonists due to their binding activities for androgen receptors (IC50 280 and 160 μM, respectively) and the inhibitory activity of androgen-induced expression of prostate-specific antigen (PSA) mRNA in LNCaP (prostate adenocarcinoma) cells (IC50 20 and 18 μM, respectively).

Published
2013
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