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31 results on '"Idowu, Bernadine"'

6. Contributor contact details

Author

Salih, Vehid, primary, Salih, Vehid, additional, Thomas, Dominique, additional, Cheema, Umber, additional, Ellis, Marianne J., additional, Birch, Mark A., additional, Wright, Kathleen, additional, Buranawat, Borvornwut, additional, Kalia, Priya, additional, Di Silvio, Lucy, additional, Tomlins, Paul, additional, Idowu, Bernadine, additional, Wall, Ivan B., additional, Davie, Natasha, additional, Chrzanowski, Wojciech, additional, Dehghani, Fariba, additional, Parsons, B., additional, and Brindley, David A., additional

Published
2013
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10. Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study

Author

Presneau, Nadège, Shalaby, Asem, Ye, Hongtao, Pillay, Nischalan, Halai, Dina, Idowu, Bernadine, Tirabosco, Roberto, Whitwell, Duncan, Jacques, Thomas S, Kindblom, Lars-Gunnar, Brüderlein, Silke, Möller, Peter, Leithner, Andreas, Liegl, Bernadette, Amary, Fernanda M, Athanasou, Nicholas N, Hogendoorn, Pancras CW, Mertens, Fredrik, Szuhai, Karoly, and Flanagan, Adrienne M

Published
2011
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15. Functionalized scaffolds for tissue engineering

Author

Zamuner Annj, Dettin Monica, Witek Lukasz, Alfayez Eman, Smay James, Coward Trevor, Idowu Bernadine, and Di Silvio Lucy

Subjects
Histology, Materials science, Tissue engineering, Biomedical Engineering, Bioengineering, Biotechnology, Biomedical engineering
Published
2016

17. Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): An ancillary diagnostic tool

Author

UCL, Fernanda, Maria, Amary, C., Pauwels, Patrick, Meulemans, Els, Roemen, Guido M., Islam, Lily, Idowu, Bernadine, Bousdras, Konstantinos, Diss, Timothy C., O'Donnell, Paul, Flanagan, Adrienne M., UCL, Fernanda, Maria, Amary, C., Pauwels, Patrick, Meulemans, Els, Roemen, Guido M., Islam, Lily, Idowu, Bernadine, Bousdras, Konstantinos, Diss, Timothy C., O'Donnell, Paul, and Flanagan, Adrienne M.

Abstract

Desmoid-type fibromatosis is a locally aggressive deep soft tissue tumor. Some cases are associated with adenosis polyposis coli germline mutations whereas others harbor somatic P-catenin point mutations mainly in exon 3, codons 41 and 45. These mutations result in stabilization of P-catenin, and activation of the Writ signaling pathway. The aim of this study was to determine the specificity and sensitivity of these 3 most common P-catenin mutations in the diagnosis of desmoid-type fibromatosis using paraffin-embedded material. The results were compared with nuclear expression of P-catenin. Mutation-specific restriction enzyme digestion methodology was employed to detect the 3 mutations. One hundred and thirty-three cases were analyzed, including 76 desinoid-type, and 18 superficial fibromatosis, in addition to a further 39 fibromatosis mimics. A restriction site was present for analysis of the codon 41 mutation. Mismatch primers were designed for the codon 45 mutations. Mutations were detected in 66 cases (87%) of 76 desmoid-type fibromatosis (71 extra-abdominal). Of these, 34 (45%) were in codon 45 (TCT > TTT), 27 (35%) in codon 41 (ACC > GCC), and 5 (7%) in codon 45 (TCT > CCT). No mutations were detected in the other lesions studied. All desmoid-type fibromatosis cases and 72% of the mimics tested

Published
2007

21. Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors

Author

Feber, Andrew, primary, Wilson, Gareth A., additional, Zhang, Lu, additional, Presneau, Nadege, additional, Idowu, Bernadine, additional, Down, Thomas A., additional, Rakyan, Vardhman K., additional, Noon, Luke A., additional, Lloyd, Alison C., additional, Stupka, Elia, additional, Schiza, Vassia, additional, Teschendorff, Andrew E., additional, Schroth, Gary P., additional, Flanagan, Adrienne, additional, and Beck, Stephan, additional

Published
2011
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22. The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target

Author

Shalaby, Asem, primary, Presneau, Nadège, additional, Ye, Hongtao, additional, Halai, Dina, additional, Berisha, Fitim, additional, Idowu, Bernadine, additional, Leithner, Andreas, additional, Liegl, Bernadette, additional, Briggs, Timothy RW, additional, Bacsi, Krisztian, additional, Kindblom, Lars‐Gunnar, additional, Athanasou, Nicholas, additional, Amary, Maria Fernanda, additional, Hogendoorn, Pancras CW, additional, Tirabosco, Roberto, additional, and Flanagan, Adrienne M, additional

Published
2010
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23. Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study

Author

Presneau, Nadège, primary, Shalaby, Asem, additional, Ye, Hongtao, additional, Pillay, Nischalan, additional, Halai, Dina, additional, Idowu, Bernadine, additional, Tirabosco, Roberto, additional, Whitwell, Duncan, additional, Jacques, Thomas S, additional, Kindblom, Lars-Gunnar, additional, Brüderlein, Silke, additional, Möller, Peter, additional, Leithner, Andreas, additional, Liegl, Bernadette, additional, Amary, Fernanda M, additional, Athanasou, Nicholas N, additional, Hogendoorn, Pancras CW, additional, Mertens, Fredrik, additional, Szuhai, Karoly, additional, and Flanagan, Adrienne M, additional

Published
2010
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27. Detection of β-Catenin Mutations in Paraffin-embedded Sporadic Desmoid-type Fibromatosis by Mutation-specific Restriction Enzyme Digestion (MSRED): an Ancillary Diagnostic Tool

Author

Amary, Maria Fernanda C., primary, Pauwels, Patrick, additional, Meulemans, Els, additional, Roemen, Guido M., additional, Islam, Lily, additional, Idowu, Bernadine, additional, Bousdras, Konstantinos, additional, Diss, Timothy C., additional, O'Donnell, Paul, additional, and Flanagan, Adrienne M., additional

Published
2007
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29. A day in the life.

Author

Idowu, Bernadine

Subjects
*CAREER development, *EDUCATORS, *MEDICAL sciences, *VETERINARY public health, *MASTER of science degree
Abstract

The article shares the day-to-day life and routine of author who is an associate professor and the Member of Royal Society of Biology who shares her efforts to increase the number of black students going on to academic careers. It mentions that she never thought she could become an associate professor of biomedical science, as she did not see anyone who looked like her when I was an undergraduate.

Published
2022

30. GNAS1mutations occur more commonly than previously thought in intramuscular myxoma

Author

Delaney, David, Diss, Tim C, Presneau, Nadege, Hing, Sandra, Berisha, Fitim, Idowu, Bernadine D, O'Donnell, P, Skinner, John A, Tirabosco, Roberto, and Flanagan, Adrienne M

Abstract

Mutation detection plays an important role in diagnostic pathology, not only in providing a tissue diagnosis, but also in predicting response to antitumourigenic agents. However, mutation detection strategies are often hampered by masking of mutant alleles by wild-type sequences. Coamplification at lower denaturation temperature PCR (COLD-PCR) reportedly increases the proportion of rare variant sequences in a wild-type background by using PCR cycles in which the denaturation temperature is reduced to favour product formation with lower melt temperatures and heteroduplexes arising from minor variants. Intramuscular myxoma is a rare benign soft tissue neoplasm that occurs sporadically and less commonly in association with fibrous dysplasia (Mazabraud's syndrome). Fibrous dysplasia results from activating GNAS1mutations, and the same mutations have been identified in small numbers of intramuscular myxoma. The aim of the study was primarily to establish whether COLD-PCR is more sensitive than conventional PCR; this was achieved by testing for GNAS1mutations in intramuscular myxomas using the two methodologies. Mutations were detected in 8 of 28 (29%) cases of intramuscular myxomas using conventional PCR followed by mutation-specific restriction enzyme digestion (PCR-MSRED) whereas 17 of 28 (61%) mutations were detected using COLD-PCR/MSRED. Mutations were detected in two cases where a diagnosis of low-grade myxofibrosarcoma had been favoured over intramuscular myxoma. No mutations were detected in an additional 9 low-grade and 19 high-grade myxofibrosarcomas, and another 40 control samples. This study shows the power of COLD-PCR compared with conventional PCR in mutation detection, and shows that GNAS1mutation detection increases diagnostic accuracy when distinguishing between intramuscular myxoma and low-grade myxofibrosarcoma.

Published
2009
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31. Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): an ancillary diagnostic tool.

Author

Amary MF, Pauwels P, Meulemans E, Roemen GM, Islam L, Idowu B, Bousdras K, Diss TC, O'Donnell P, and Flanagan AM

Subjects
Adolescent, Adult, Aged, Base Sequence, Cell Nucleus chemistry, Child, Codon, Diagnosis, Differential, Female, Fibromatosis, Aggressive genetics, Fibromatosis, Aggressive metabolism, Fibromatosis, Aggressive pathology, Humans, Immunohistochemistry methods, Magnetic Resonance Imaging, Male, Middle Aged, Molecular Sequence Data, Paraffin Embedding, Predictive Value of Tests, Sensitivity and Specificity, Tissue Array Analysis, beta Catenin analysis, DNA Mutational Analysis methods, Fibromatosis, Aggressive diagnosis, Gene Expression Regulation, Neoplastic, Mutation, Restriction Mapping, beta Catenin genetics
Abstract

Desmoid-type fibromatosis is a locally aggressive deep soft tissue tumor. Some cases are associated with adenosis polyposis coli germline mutations whereas others harbor somatic beta-catenin point mutations mainly in exon 3, codons 41 and 45. These mutations result in stabilization of beta-catenin, and activation of the Wnt signaling pathway. The aim of this study was to determine the specificity and sensitivity of these 3 most common beta-catenin mutations in the diagnosis of desmoid-type fibromatosis using paraffin-embedded material. The results were compared with nuclear expression of beta-catenin. Mutation-specific restriction enzyme digestion methodology was employed to detect the 3 mutations. One hundred and thirty-three cases were analyzed, including 76 desmoid-type, and 18 superficial fibromatosis, in addition to a further 39 fibromatosis mimics. A restriction site was present for analysis of the codon 41 mutation. Mismatch primers were designed for the codon 45 mutations. Mutations were detected in 66 cases (87%) of 76 desmoid-type fibromatosis (71 extra-abdominal). Of these, 34 (45%) were in codon 45 (TCT>TTT), 27 (35%) in codon 41 (ACC>GCC), and 5 (7%) in codon 45 (TCT>CCT). No mutations were detected in the other lesions studied. All desmoid-type fibromatosis cases and 72% of the mimics tested showed nuclear positivity for beta-catenin indicating immunohistochemistry is a sensitive but not a specific test for desmoid-type fibromatosis. In contrast, to date, beta-catenin mutations have not been detected in any lesions which mimic desmoid-type fibromatosis. Mutation-specific restriction enzyme digestion, a simple and efficient means of detecting the common beta-catenin mutations in desmoid-type fibromatosis, complements light microscopy in reaching a diagnosis.

Published
2007
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