Search

Your search keyword '"Idzikowski, Emma"' showing total 14 results
Start Over Author "Idzikowski, Emma"
14 results on '"Idzikowski, Emma"'

1. Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood

Author

Connors, Thomas J., Matsumoto, Rei, Verma, Shivali, Szabo, Peter A., Guyer, Rebecca, Gray, Joshua, Wang, Zicheng, Thapa, Puspa, Dogra, Pranay, Poon, Maya M.L., Rybkina, Ksenia, Bradley, Marissa C., Idzikowski, Emma, McNichols, James, Kubota, Masaru, Pethe, Kalpana, Shen, Yufeng, Atkinson, Mark A., Brusko, Maigan, Brusko, Todd M., Yates, Andrew J., Sims, Peter A., and Farber, Donna L.

Published
2023
Full Text
View/download PDF

2. Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Author

Weisberg, Stuart P., Connors, Thomas J., Zhu, Yun, Baldwin, Matthew R., Lin, Wen-Hsuan, Wontakal, Sandeep, Szabo, Peter A., Wells, Steven B., Dogra, Pranay, Gray, Joshua, Idzikowski, Emma, Stelitano, Debora, Bovier, Francesca T., Davis-Porada, Julia, Matsumoto, Rei, Poon, Maya Meimei Li, Chait, Michael, Mathieu, Cyrille, Horvat, Branka, Decimo, Didier, Hudson, Krystalyn E., Zotti, Flavia Dei, Bitan, Zachary C., La Carpia, Francesca, Ferrara, Stephen A., Mace, Emily, Milner, Joshua, Moscona, Anne, Hod, Eldad, Porotto, Matteo, and Farber, Donna L.

Published
2021
Full Text
View/download PDF

6. Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

Author

Szabo, Peter A., primary, Dogra, Pranay, additional, Gray, Joshua I., additional, Wells, Steven B., additional, Connors, Thomas J., additional, Weisberg, Stuart P., additional, Krupska, Izabela, additional, Matsumoto, Rei, additional, Poon, Maya M.L., additional, Idzikowski, Emma, additional, Morris, Sinead E., additional, Pasin, Chloé, additional, Yates, Andrew J., additional, Ku, Amy, additional, Chait, Michael, additional, Davis-Porada, Julia, additional, Guo, Xinzheng V., additional, Zhou, Jing, additional, Steinle, Matthew, additional, Mackay, Sean, additional, Saqi, Anjali, additional, Baldwin, Matthew R., additional, Sims, Peter A., additional, and Farber, Donna L., additional

Published
2021
Full Text
View/download PDF

7. Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Author

Weisberg, Stuart P., primary, Connors, Thomas J., additional, Zhu, Yun, additional, Baldwin, Matthew R., additional, Lin, Wen-Hsuan, additional, Wontakal, Sandeep, additional, Szabo, Peter A., additional, Wells, Steven B., additional, Dogra, Pranay, additional, Gray, Joshua, additional, Idzikowski, Emma, additional, Stelitano, Debora, additional, Bovier, Francesca T., additional, Davis-Porada, Julia, additional, Matsumoto, Rei, additional, Poon, Maya Meimei Li, additional, Chait, Michael, additional, Mathieu, Cyrille, additional, Horvat, Branka, additional, Decimo, Didier, additional, Hudson, Krystalyn E., additional, Zotti, Flavia Dei, additional, Bitan, Zachary C., additional, La Carpia, Francesca, additional, Ferrara, Stephen A., additional, Mace, Emily, additional, Milner, Joshua, additional, Moscona, Anne, additional, Hod, Eldad, additional, Porotto, Matteo, additional, and Farber, Donna L., additional

Published
2020
Full Text
View/download PDF

8. Analysis of respiratory and systemic immune responses in COVID-19 reveals mechanisms of disease pathogenesis

Author

Szabo, Peter A., primary, Dogra, Pranay, additional, Gray, Joshua I., additional, Wells, Steven B., additional, Connors, Thomas J., additional, Weisberg, Stuart P., additional, Krupska, Izabela, additional, Matsumoto, Rei, additional, Poon, Maya M.L., additional, Idzikowski, Emma, additional, Morris, Sinead E., additional, Pasin, Chloé, additional, Yates, Andrew J., additional, Ku, Amy, additional, Chait, Michael, additional, Davis-Porada, Julia, additional, Zhou, Jing, additional, Steinle, Matthew, additional, Mackay, Sean, additional, Saqi, Anjali, additional, Baldwin, Matthew, additional, Sims, Peter A., additional, and Farber, Donna L., additional

Published
2020
Full Text
View/download PDF

9. Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19

Author

Weisberg, Stuart P., primary, Connors, Thomas, additional, Zhu, Yun, additional, Baldwin, Matthew, additional, Lin, Wen-hsuan, additional, Wontakal, Sandeep, additional, Szabo, Peter A., additional, Wells, Steven B., additional, Dogra, Pranay, additional, Gray, Joshua, additional, Idzikowski, Emma, additional, Bovier, Francesca T., additional, Davis-Porada, Julia, additional, Matsumoto, Rei, additional, Li Poon, Maya Meimei, additional, Chait, Michael, additional, Mathieu, Cyrille, additional, Horvat, Branka, additional, Decimo, Didier, additional, Bitan, Zachary C., additional, La Carpia, Francesca, additional, Ferrara, Stephen A., additional, Mace, Emily, additional, Milner, Joshua, additional, Moscona, Anne, additional, Hod, Eldad, additional, Porotto, Matteo, additional, and Farber, Donna L., additional

Published
2020
Full Text
View/download PDF

12. Analysis of respiratory and systemic immune responses in COVID-19 reveals mechanisms of disease pathogenesis.

Author

Szabo PA, Dogra P, Gray JI, Wells SB, Connors TJ, Weisberg SP, Krupska I, Matsumoto R, Poon MML, Idzikowski E, Morris SE, Pasin C, Yates AJ, Ku A, Chait M, Davis-Porada J, Zhou J, Steinle M, Mackay S, Saqi A, Baldwin M, Sims PA, and Farber DL

Abstract

Immune responses to respiratory viruses like SARS-CoV-2 originate and function in the lung, yet assessments of human immunity are often limited to blood. Here, we conducted longitudinal, high-dimensional profiling of paired airway and blood samples from patients with severe COVID-19, revealing immune processes in the respiratory tract linked to disease pathogenesis. Survival from severe disease was associated with increased CD4 + T cells and decreased monocyte/macrophage frequencies in the airway, but not in blood. Airway T cells and macrophages exhibited tissue-resident phenotypes and activation signatures, including high level expression and secretion of monocyte chemoattractants CCL2 and CCL3 by airway macrophages. By contrast, monocytes in blood expressed the CCL2-receptor CCR2 and aberrant CD163 + and immature phenotypes. Extensive accumulation of CD163 + monocyte/macrophages within alveolar spaces in COVID-19 lung autopsies suggested recruitment from circulation. Our findings provide evidence that COVID-19 pathogenesis is driven by respiratory immunity, and rationale for site-specific treatment and prevention strategies.

Published
2020
Full Text
View/download PDF

13. Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19.

Author

Weisberg SP, Connors T, Zhu Y, Baldwin M, Lin WH, Wontakal S, Szabo PA, Wells SB, Dogra P, Gray JI, Idzikowski E, Bovier F, Davis-Porada J, Matsumoto R, Li Poon MM, Chait MP, Mathieu C, Horvat B, Decimo D, Bitan ZC, La Carpia F, Ferrara SA, Mace E, Milner J, Moscona A, Hod EA, Porotto M, and Farber DL

Abstract

Clinical manifestations of COVID-19 caused by the novel coronavirus SARS-CoV-2 are associated with age. While children are largely spared from severe respiratory disease, they can present with a SARS-CoV-2-associated multisystem inflammatory syndrome (MIS-C) similar to Kawasaki's disease. Here, we show distinct antibody (Ab) responses in children with MIS-C compared to adults with severe COVID-19 causing acute respiratory distress syndrome (ARDS), and those who recovered from mild disease. There was a reduced breadth and specificity of anti-SARS-CoV-2-specific antibodies in MIS-C patients compared to the COVID patient groups; MIS-C predominantly generated IgG Abs specific for the Spike (S) protein but not for the nucleocapsid (N) protein, while both COVID-19 cohorts had anti-S IgG, IgM and IgA Abs, as well as anti-N IgG Abs. Moreover, MIS-C patients had reduced neutralizing activity compared to COVID-19 cohorts, indicating a reduced protective serological response. These results suggest a distinct infection course and immune response in children and adults who develop severe disease, with implications for optimizing treatments based on symptom and age.

Published
2020
Full Text
View/download PDF

14. Differences in neuroplasticity after spinal cord injury in varying animal models and humans.

Author

Filipp ME, Travis BJ, Henry SS, Idzikowski EC, Magnuson SA, Loh MY, Hellenbrand DJ, and Hanna AS

Abstract

Rats have been the primary model to study the process and underlying mechanisms of recovery after spinal cord injury. Two weeks after a severe spinal cord contusion, rats can regain weight-bearing abilities without therapeutic interventions, as assessed by the Basso, Beattie and Bresnahan locomotor scale. However, many human patients suffer from permanent loss of motor function following spinal cord injury. While rats are the most understood animal model, major differences in sensorimotor pathways between quadrupeds and bipeds need to be considered. Understanding the major differences between the sensorimotor pathways of rats, non-human primates, and humans is a start to improving targets for treatments of human spinal cord injury. This review will discuss the neuroplasticity of the brain and spinal cord after spinal cord injury in rats, non-human primates, and humans. A brief overview of emerging interventions to induce plasticity in humans with spinal cord injury will also be discussed., Competing Interests: None

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results