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431 results on '"Ignaszewski, Andrew"'

1. Regulatory T Cell Biomarkers Identify Patients at Risk of Developing Acute Cellular Rejection in the First Year Following Heart Transplantation

Author

Kim, Ji-Young V., Assadian, Sara, Hollander, Zsuzsanna, Burns, Paloma, Shannon, Casey P., Lam, Karen, Toma, Mustafa, Ignaszewski, Andrew, Davies, Ross A., Delgado, Diego, Haddad, Haissam, Isaac, Debra, Kim, Daniel, Mui, Alice, Rajda, Miroslaw, West, Lori, White, Michel, Zieroth, Shelley, Keown, Paul A., McMaster, W. Robert, Ng, Raymond T., McManus, Bruce M., Levings, Megan K., and Tebbutt, Scott J.

Published
2023
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2. HEARTBiT: A Transcriptomic Signature for Excluding Acute Cellular Rejection in Adult Heart Allograft Patients

Author

Shannon, Casey P., Hollander, Zsuzsanna, Dai, Darlene L.Y., Chen, Virginia, Assadian, Sara, Lam, Karen K., McManus, Janet E., Zarzycki, Marek, Kim, YoungWoong, Kim, Ji-Young V., Balshaw, Robert, Gidlöf, Olof, Öhman, Jenny, Smith, J. Gustav, Toma, Mustafa, Ignaszewski, Andrew, Davies, Ross A., Delgado, Diego, Haddad, Haissam, Isaac, Debra, Kim, Daniel, Mui, Alice, Rajda, Miroslaw, West, Lori, White, Michel, Zieroth, Shelley, Tebbutt, Scott J., Keown, Paul A., McMaster, W. Robert, Ng, Raymond T., and McManus, Bruce M.

Published
2020
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10. HEARTBIT: A Novel Biosignature for Detection of Acute Cellular Rejection of Heart Allografts

Author

Shannon, Casey P, Hollander, Zsuzsanna, Assadian, Sara, Lam, Karen, Chen, Virginia, Dai, LiYing, Zarzycki, Marek, Kim, YoungWoong, Kim, Ji-Young, Balshaw, Robert, Dewi, Ihdina S, Gidlöf, Olof, Öhman, Jenny, Smith, Gustav, Toma, Mustafa, Davies, Ross, Delgado, Diego, Haddad, Haissam, Ignaszewski, Andrew, Isaac, Debra, Kim, Daniel, Mui, Alice, Rajda, Miroslav, West, Lori, White, Michel, Zieroth, Shelley, Tebbutt, Scott J, Keown, Paul, McMaster, Robert, Ng, Raymond T, and McManus, Bruce M

Published
2018
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13. Randomized Ablation-Based Rhythm-Control Versus Rate-Control Trial in Patients With Heart Failure and Atrial Fibrillation: Results from the RAFT-AF trial

Author

Parkash, Ratika, primary, Wells, George A., additional, Rouleau, Jean, additional, Talajic, Mario, additional, Essebag, Vidal, additional, Skanes, Allan, additional, Wilton, Stephen B., additional, Verma, Atul, additional, Healey, Jeffrey S., additional, Sterns, Laurence, additional, Bennett, Matthew, additional, Roux, Jean-Francois, additional, Rivard, Lena, additional, Leong-Sit, Peter, additional, Jensen-Urstad, Mats, additional, Jolly, Umjeet, additional, Philippon, Francois, additional, Sapp, John L., additional, Tang, Anthony S.L., additional, MacDonald, Paul, additional, Chakrabarti, Santabhanu, additional, Yeung-Lai-Wah, John, additional, Ignaszewski, Andrew, additional, Tung, Stanley, additional, Virani, Shahnawaz, additional, Deyell, Marc, additional, Krahn, Andrew, additional, Andrade, Jason, additional, Straatman, Lynn, additional, Toma, Mustafa, additional, Wong, Graham, additional, Wei, Matthew, additional, Greiss, Isabelle, additional, Raymond, Jean-Marc, additional, Coutu, Benoit, additional, Costi, Paolo, additional, Mansour, Fadi, additional, Saint-Phard, Wouter, additional, Denis, Isabelle, additional, Fleury, Julie, additional, Ayala-Paredes, Felix, additional, Badra-Verdu, Mariano, additional, Dussault, Charles, additional, Vachon, Nadia, additional, Dagenais, Véronique, additional, Lamoureux, Caroline, additional, Healey, Jeff, additional, Connolly, Stuart, additional, Ribas, C. Sebastien, additional, Divakaramenon, Syamkumar, additional, Wong, Jorge, additional, Amit, Guy, additional, Meyer, Wendy, additional, Nault, Isabelle, additional, Champagne, Jean, additional, Sarrazin, Jean-Francois, additional, O’Hara, Gilles, additional, Blier, Louis, additional, Plourde, Benoit, additional, Steinburg, Christian, additional, Roy, Karine, additional, Banville, Paule, additional, Ottinger, Brigitte, additional, Boucher, Marie-Eve, additional, Sanchez, Marina, additional, Dubuc, Marc, additional, Guerra, Peter, additional, Dyrda, Katia, additional, Khairy, Paul, additional, Macle, Laurent, additional, Mondesert, Blandine, additional, Roy, Denis, additional, Thibault, Bernard, additional, Tadros, Rafik, additional, Roy, Véronique, additional, Redfearn, Damian, additional, Abdollah, Hoshiar, additional, Baranchuk, Adrian, additional, Michael, Kevin, additional, Simpson, Christopher, additional, Hammond, Sharlene, additional, Clarke, Brian, additional, Morillo, Carlos, additional, Kuriachan, Vikas, additional, Veenhuyzen, George, additional, Quinn, Russell, additional, Exner, Derek, additional, Howlett, Jonathan, additional, McKeage, Jennifer, additional, Gula, Lorne, additional, Manlucu, Jaimie, additional, Tang, Anthony, additional, Klein, George, additional, Wall, Sabrina, additional, El-Sakka, Yomna, additional, Hadjis, Tom, additional, Bernier, Martin, additional, Joza, Jacqueline, additional, Roux, Jean- Francois, additional, Omelchenko, Alexander, additional, Nascimento, Thais, additional, Rafti, Fiorella, additional, DiStefano, Ida, additional, Parkash, Ratika, additional, Sapp, John, additional, Gray, Chris, additional, Gardner, Martin, additional, Abdel-Wahab, Amir, additional, MacIntyre, Ciorsti J, additional, Rajda, Miroslaw, additional, O’Regan, Patrick, additional, Levins-Lamont, Mary Lee, additional, Lockwood, Evan, additional, Hruczkowski, Tom, additional, Valtuille, Lucas, additional, Chan, Michael, additional, Halenar, Jennifer, additional, McLean, Samantha, additional, Khaykin, Yaariv, additional, Nyman, Lynn, additional, Wulffhart, Zaev, additional, Pantano, Alfredo, additional, Tsang, Bernice, additional, Patterson, Sherri, additional, Nath, Annette, additional, Rinne, Clause, additional, Janzen, Irene, additional, Crystal, Eugene, additional, Lashevsky, Ilan, additional, Singh, Sheldon, additional, Tiong, Irving, additional, Syeda, Ambreen, additional, Tremblay, Anyur, additional, Ha, Andrew C. T., additional, Chauhan, Vijay, additional, Hill, Ann, additional, Nery, Pablo, additional, Birnie, David, additional, Redpath, Calum, additional, Green, Martin, additional, Nair, Girish, additional, Lemery, Robert, additional, Sadek, Mouhannad, additional, MacDonald, Karen, additional, Novak, Paul, additional, Leather, Richard, additional, Swiggum, Elizabeth, additional, Sikkel, Markus, additional, Lane, Chris, additional, Rakochey, Tanner, additional, Patterson, Caitlin, additional, Luz Leiria, Tiago Luiz, additional, Glotz de Lima, Gustavo, additional, Sant’Anna, Roberto, additional, Dutz, Eduardo, additional, Klein Weber, Cristina, additional, Peixoto Deiro, Aline, additional, Hoscheidt, Laís Machado, additional, Linde, Cecile, additional, Saluveer, Ott, additional, Carnlof, Carina, additional, Yu, Chih-Chieh, additional, Chiu, Fu-Chun, additional, Lin, Jiunn-Lee, additional, Huang, Cheng-Yu, additional, Theoret-Patrick, Patricia, additional, Ryan, Janine, additional, Tran, My-Linh, additional, Chen, Li, additional, Singh, Sarah, additional, Wells, George, additional, Newton, Gary, additional, Coyle, Doug, additional, Wyse, George, additional, Cassidy, Dennis, additional, Thabane, Lehana, additional, Mielniczuk, Lisa, additional, Ha, Andrew, additional, Luz Leiria, TIago Luiz, additional, Tzemos, Niko, additional, Mathew, Andrew, additional, Thain, De, additional, MacDonald, Anita, additional, and Shields, Marcia, additional

Published
2022
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18. Authors' reply

Author

Chua, Doson and Ignaszewski, Andrew

Published
2009

22. Psychosocial and medical predictors of 14-year mortality and morbidity in male and female coronary artery bypass graft recipients: a prospective observational study.

Author

Linden, Wolfgang, Young, Sandra, Ignaszewski, Andrew, and Campbell, Tavis

Subjects
CORONARY artery bypass, SCIENTIFIC observation, SOCIAL support, CONFIDENCE intervals, TIME, PSYCHOLOGY of cardiac patients, FUNCTIONAL status, SEX distribution, DISEASE relapse, MENTAL depression, REOPERATION, SURVIVAL analysis (Biometry), DESCRIPTIVE statistics, CHI-squared test, MARITAL status, LONGITUDINAL method
Abstract

Background: Psychosocial factors may influence mortality and morbidity after coronary bypass surgery (CABG), but it is unclear when, post-surgery, they best predict the outcome, if they interact, or whether results differ for men and women. Methods: This prospective, observational study assessed depression symptoms, social support, marital status, household responsibility, functional impairment, mortality and need for further coronary procedures over 14 years of follow-up. Data were collected in-hospital post-CABG and at home 1-year later. Mortality and subsequent cardiac procedure data were extracted from a Cardiac Registry. Results: Of 296 baseline participants, 78% (43% were women) completed data at 1-year post-CABG. Long-term survival was shorter with 1-year depression and lower household responsibility but that was not true for the measures taken at baseline [HR for depression = 1.27; 95% CI 1.02–1.59 v. 0.99 (0.78–1.25), and HR = 0.71; 95% CI 0.52–0.97 v. 0.97 (0.80–1.16)] for household responsibility. An interaction between depression symptoms and social support at year 1 [χ2 (11) = 111.05, p < 0.001] revealed a greater hazard of mortality d with increased depression only at mean (HR = 1.67; 95% CI 1.21–2.26) and high social support (HR = 2.23; 95% CI 1.46–3.40). Depression also accounted for increased event recurrence. There were no significant interactions of sex with medical long-term outcomes. Conclusions: In a sex-balanced sample, depression and household responsibility measured at 1-year post-CABG were associated with significant variance in unadjusted and adjusted predictor models of long-term mortality whereas the same indices determined right after the procedure were not significant predictors. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Cardiac rehabilitation: a comprehensive review

Author

Lear Scott A and Ignaszewski Andrew

Subjects
cardiac rehabilitation, cardiovascular disease, exercise therapy, lifestyle interventions, secondary prevention, Medicine (General), R5-920
Abstract

Abstract Cardiac rehabilitation (CR) is a commonly used treatment for men and women with cardiovascular disease. To date, no single study has conclusively demonstrated a comprehensive benefit of CR. Numerous individual studies, however, have demonstrated beneficial effects such as improved risk-factor profile, slower disease progression, decreased morbidity, and decreased mortality. This paper will review the evidence for the use of CR and discuss the implications and limitations of these studies. The safety, relevance to special populations, challenges, and future directions of CR will also be reviewed.

Published
2001
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27. Proteomic biomarkers of recovered heart function

Author

Hollander, Zsuzsanna, Lazárová, Marie, Lam, Karen K.Y., Ignaszewski, Andrew, Oudit, Gavin Y., Dyck, Jason R. B., Schreiner, George, Pauwels, Julie, Chen, Virginia, Cohen Freue, Gabriela V., Ng, Raymond T., Wilson-McManus, Janet E., Balshaw, Robert, Tebbutt, Scott J., McMaster, Robert W., Keown, Paul A., and McManus, Bruce M.

Published
2014
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29. Canadian Cardiovascular Society Consensus Conference recommendations on heart failure update 2007: Prevention, management during intercurrent illness or acute decompensation, and use of biomarkers

Author

Arnold, J. Malcolm O., Howlett, Jonathan G., Dorian, Paul, Ducharme, Anique, Giannetti, Nadia, Haddad, Haissam, Heckman, George A., Ignaszewski, Andrew, Isaac, Debra, Jong, Philip, Liu, Peter, Mann, Elizabeth, McKelvie, Robert S., Moe, Gordon W., Parker, John D., Svendsen, Anna M., Tsuyuki, Ross T., O’Halloran, Kelly, Ross, Heather J., Rao, Vivek, Sequeira, Errol J., and White, Michel

Published
2007
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31. The Extensive Lifestyle Management Intervention (ELMI) after cardiac rehabilitation: A 4-year randomized controlled trial

Author

Lear, Scott A., Spinelli, John J., Linden, Wolfgang, Brozic, Anka, Kiess, Marla, Frohlich, Jiri J., and Ignaszewski, Andrew

Subjects
Cancer -- Research, Oncology, Experimental, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2005.12.023 Byline: Scott A. Lear (a)(b), John J. Spinelli (c), Wolfgang Linden (d), Anka Brozic (e), Marla Kiess (b), Jiri J. Frohlich (f), Andrew Ignaszewski (b) Abstract: Previous reports indicate risk factors and lifestyle behaviors may deteriorate early after completion of a cardiac rehabilitation program (CRP). We hypothesized that a modest risk factor and lifestyle management intervention after a CRP would significantly reduce overall cardiovascular risk using the Framingham risk score compared with usual care after 4 years. Author Affiliation: (a) School of Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada (b) Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada (c) Cancer Control Research Program, British Columbia Cancer Agency, British Columbia, Canada (d) Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada (e) Healthy Heart Program, Vancouver General Hospital, Vancouver, British Columbia, Canada (f) Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada Article History: Received 14 September 2005; Accepted 24 December 2005 Article Note: (footnote) This study was funded by the British Columbia Health Research Foundation. Dr Lear's salary was provided by the Michael Smith Foundation for Health Research.

Published
2006

33. Canadian Cardiovascular Society consensus conference recommendations on heart failure 2006: Diagnosis and management

Author

Arnold, J. Malcolm O., Liu, Peter, Demers, Catherine, Dorian, Paul, Giannetti, Nadia, Haddad, Haissam, Heckman, George A., Howlett, Jonathan G., Ignaszewski, Andrew, Johnstone, David E., Jong, Philip, McKelvie, Robert S., Moe, Gordon W., Parker, John D., Rao, Vivek, Ross, Heather J., Sequeira, Errol J., Svendsen, Anna M., Teo, Koon, Tsuyuki, Ross T., and White, Michel

Published
2006
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43. Differentiating heart failure phenotypes using sex‐specific transcriptomic and proteomic biomarker panels

Author

Toma, Mustafa, Mak, George J., Chen, Virginia, Hollander, Zsuzsanna, Shannon, Casey P., Lam, Karen K.Y., Ng, Raymond T., Tebbutt, Scott J., Wilson‐McManus, Janet E., Ignaszewski, Andrew, Anderson, Todd, Dyck, Jason R.B., Howlett, Jonathan, Ezekowitz, Justin, McManus, Bruce M., and Oudit, Gavin Y.

Subjects
Proteomics, Heart failure with preserved ejection fraction, Original Research Articles, Heart failure, Original Research Article, Heart failure with reduced ejection fraction, Transcriptomics, Biomarkers
Abstract

Aims Heart failure with preserved ejection fraction (HFpEF) accounts for 30–50% of patients with heart failure (HF). A major obstacle in HF management is the difficulty in differentiating between HFpEF and heart failure with reduced ejection fraction (HFrEF) using conventional clinical and laboratory investigations. The aim of this study is to develop robust transcriptomic and proteomic biomarker signatures that can differentiate HFpEF from HFrEF. Methods and results A total of 210 HF patients were recruited in participating institutions from the Alberta HEART study. An expert clinical adjudicating panel differentiated between patients with HFpEF and HFrEF. The discovery cohort consisted of 61 patients, and the replication cohort consisted of 70 patients. Transcriptomic and proteomic data were analysed to find panels of differentiating HFpEF from HFrEF. In the discovery cohort, a 22‐transcript panel was found to differentiate HFpEF from HFrEF in male patients with a cross‐validation AUC of 0.74, as compared with 0.70 for N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) in those same patients. An ensemble of the transcript panel and NT‐pro‐BNP yielded a cross‐validation AUC of 0.80. This performance improvement was also observed in the replication cohort. An ensemble of the transcriptomic panel with NT‐proBNP produced a replication AUC of 0.90, as compared with 0.74 for NT‐proBNP alone and 0.73 for the transcriptomic panel. Conclusions We have identified a male‐specific transcriptomic biomarker panel that can differentiate between HFpEF and HFrEF. These biosignatures could be further replicated on other patients and potentially be developed into a blood test for better management of HF patients.

Published
2017

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