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Mine blast injuries occupy one of the leading places among the total number of injuries received during combat operations. Victims who are lucky enough to survive the incident often lose working capacity for life. Significant contamination and complete or partial loss of limb tissue require urgent medical care followed by tissue reconstruction aimed at restoring limb function and eliminating pain syndrome. At the same time, in the absence of adequate cleaning of the injury of the limbs and the impossibility of its reconstruction, the most frequent result in the treatment of patients of this category is the amputation of the affected limb. Among the possible effective means that help to improve the results of treatment and reduce the risks of negative consequences is the wound therapy with negative pressure (Vacuum assisted closure (VAC)/negative pressure wound therapy (NPWT)), which has become a generally accepted method in the process of curation of patients with mine blast injuries. [ABSTRACT FROM AUTHOR]