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3. Achalasia phenotypes and prediction of peroral endoscopic myotomy outcomes using machine learning.

Author

Takahashi, Kazuya, Sato, Hiroki, Shimamura, Yuto, Abe, Hirofumi, Shiwaku, Hironari, Shiota, Junya, Sato, Chiaki, Hamada, Kenta, Ominami, Masaki, Hata, Yoshitaka, Fukuda, Hisashi, Ogawa, Ryo, Nakamura, Jun, Tatsuta, Tetsuya, Ikebuchi, Yuichiro, Yokomichi, Hiroshi, Terai, Shuji, and Inoue, Haruhiro

Subjects
ESOPHAGEAL achalasia, MACHINE learning, GASTROESOPHAGEAL reflux, PHENOTYPES, MYOTOMY, BODY mass index, ESOPHAGEAL motility
Abstract

Objectives: High‐resolution manometry (HRM) and esophagography are used for achalasia diagnosis; however, achalasia phenotypes combining esophageal motility and morphology are unknown. Moreover, predicting treatment outcomes of peroral endoscopic myotomy (POEM) in treatment‐naïve patients remains an unmet need. Methods: In this multicenter cohort study, we included 1824 treatment‐naïve patients diagnosed with achalasia. In total, 1778 patients underwent POEM. Clustering by machine learning was conducted to identify achalasia phenotypes using patients' demographic data, including age, sex, disease duration, body mass index, and HRM/esophagography findings. Machine learning models were developed to predict persistent symptoms (Eckardt score ≥3) and reflux esophagitis (RE) (Los Angeles grades A–D) after POEM. Results: Machine learning identified three achalasia phenotypes: phenotype 1, type I achalasia with a dilated esophagus (n = 676; 37.0%); phenotype 2, type II achalasia with a dilated esophagus (n = 203; 11.1%); and phenotype 3, late‐onset type I–III achalasia with a nondilated esophagus (n = 619, 33.9%). Types I and II achalasia in phenotypes 1 and 2 exhibited different clinical characteristics from those in phenotype 3, implying different pathophysiologies within the same HRM diagnosis. A predictive model for persistent symptoms exhibited an area under the curve of 0.70. Pre‐POEM Eckardt score ≥6 was the greatest contributing factor for persistent symptoms. The area under the curve for post‐POEM RE was 0.61. Conclusion: Achalasia phenotypes combining esophageal motility and morphology indicated multiple disease pathophysiologies. Machine learning helped develop an optimal risk stratification model for persistent symptoms with novel insights into treatment resistance factors. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Docking Proteins Upregulate IL-1β Expression in Lower Esophageal Sphincter Muscle in Esophageal Achalasia.

Author

Kanda, Tsutomu, Saiki, Karen, Kurumi, Hiroki, Yoshida, Akira, Ikebuchi, Yuichiro, Sakaguchi, Takuki, Urabe, Shigetoshi, Minami, Hitomi, Yamaguchi, Naoyuki, Nakao, Kazuhiko, Inoue, Haruhiro, and Isomoto, Hajime

Subjects
ESOPHAGEAL achalasia, ESOPHAGOGASTRIC junction, GENE expression, SIGNAL recognition particle receptor, SPHINCTERS
Abstract

Background/Objectives: Esophageal achalasia is an archetypal esophageal motility disorder characterized by abnormal peristalsis of the esophageal body and impaired lower esophageal sphincter (LES) relaxation. Methods: In this study, the mRNA expression of docking proteins 1 and 2 (DOK1 and DOK2, respectively) were analyzed and the mechanisms underlying achalasia onset were investigated. Results: DOK1 and DOK2 mRNA levels significantly increased in the LES of patients with achalasia. Moreover, significant correlations were observed between IL-1β and DOK1, IL-1β and DOK2, ATG16L1 and DOK1, and HSV1-miR-H1-3p and DOK2 expression levels. However, a correlation between ATG16L1 and DOK2 or between HSV-miR-H1-3p and DOK1 expression was not observed. In addition, a positive correlation was observed between patient age and DOK1 expression. Microarray analysis revealed a significant decrease in the expression of hsa-miR-377-3p and miR-376a-3p in the LES muscle of patients with achalasia. Conclusions: These miRNAs possessed sequences targeting DOK. The upregulation of DOK1 and DOK2 expression induces IL-1β expression in the LES of achalasia patients, which may contribute to the development of esophageal motility disorder. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Acceptability, Safety, and Feasibility of Transnasal and Peroral Ultrathin Endoscopy Using GAGLESS Mouthpieces: A Prospective Randomized Trial

Author

MATSUMOTO, KAZUYA, primary, IMAGAWA, ATSUSHI, additional, UEDA, NAOKI, additional, WATABE, HIROTSUGU, additional, IKEBUCHI, YUICHIRO, additional, KURUMI, HIROKI, additional, SASAKI, YU, additional, ABE, YASUHIKO, additional, ABE, RYO, additional, MABE, KATSUHIRO, additional, NOMA, HISASHI, additional, FUJIWARA, KAZUNORI, additional, UEKI, MASARU, additional, FUJISHIRO, MITSUHIRO, additional, and ISOMOTO, HAJIME, additional

Published
2024
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6. Achalasia phenotypes and prediction of per‐oral endoscopic myotomy outcomes using machine learning

Author

Takahashi, Kazuya, primary, Sato, Hiroki, additional, Shimamura, Yuto, additional, Abe, Hirofumi, additional, Shiwaku, Hironari, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Hamada, Kenta, additional, Ominami, Masaki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Terai, Shuji, additional, and Inoue, Haruhiro, additional

Published
2023
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7. Clinical characteristics of absent contractility and ineffective esophageal motility: a multicenter study in Japan.

Author

Ikebuchi, Yuichiro, Sato, Hiroki, Ikeda, Haruo, Abe, Hirofumi, Ominami, Masaki, Shiota, Junya, Sato, Chiaki, Fukuda, Hisashi, Ogawa, Ryo, Tatsuta, Tetsuya, Yokomichi, Hiroshi, Isomoto, Hajime, and Inoue, Haruhiro

Subjects
*ESOPHAGEAL motility, *ESOPHAGEAL motility disorders, *GASTROESOPHAGEAL reflux, *ESOPHAGEAL achalasia, *SYSTEMIC scleroderma, *NEUROMUSCULAR diseases, *DISEASE progression
Abstract

Background and Aim: Absent contractility (AC) and ineffective esophageal motility (IEM) are esophageal hypomotility disorders diagnosed using high‐resolution manometry (HRM). Patient characteristics and disease course of these conditions and differential diagnosis between AC and achalasia are yet to be elucidated. Methods: A multicenter study involving 10 high‐volume hospitals was conducted. Starlet HRM findings were compared between AC and achalasia. Patient characteristics including underlying disorders and disease courses were analyzed in AC and IEM. Results: Fifty‐three patients with AC and 92 with IEM were diagnosed, while achalasia was diagnosed in 1784 patients using the Chicago classification v3.0 (CCv3.0). The cut‐off integrated relaxation pressure (IRP) value at 15.7 mmHg showed maximum sensitivity (0.80) and specificity (0.87) for differential diagnosis of AC from type I achalasia. While most ACs were based on systemic disorders such as scleroderma (34%) and neuromuscular diseases (8%), 23% were sporadic cases. The symptom severity of AC was not higher than that of IEM. Regarding the diagnosis of IEM, the more stringent CCv4.0 excluded 14.1% of IEM patients than the CCv3.0, although patient characteristics did not change. In patients with the hypomotile esophagus, concomitance of reflux esophagitis was associated with low distal contractile integral and IRP values. AC and IEM transferred between each other, paralleling with the underlying disease course, although no transition to achalasia was observed. Conclusion: A successful determination of the optimal cut‐off IRP value was achieved using the starlet HRM system to differentiate AC and achalasia. Follow‐up HRM is also useful for differentiating AC from achalasia. Symptom severity may depend on underlying diseases instead of hypomotility severity. [ABSTRACT FROM AUTHOR]

Published
2023
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10. A multicenter prospective study of the treatment and outcome of patients with gastroduodenal peptic ulcer bleeding in Japan

Author

Kawaguchi, Koichiro, primary, Yoshida, Akira, additional, Yuki, Takafumi, additional, Shibagaki, Kotaro, additional, Tanaka, Hisao, additional, Fujishiro, Hirofumi, additional, Miyaoka, Youichi, additional, Yanagitani, Atsushi, additional, Koda, Masaharu, additional, Ikuta, Yukihiro, additional, Hamamoto, Tetsuro, additional, Mukoyama, Tomoyuki, additional, Sasaki, Yuichiro, additional, Kushiyama, Yoshinori, additional, Yuki, Mika, additional, Noguchi, Naoya, additional, Miura, Masahiko, additional, Ikebuchi, Yuichiro, additional, Yashima, Kazuo, additional, Kinoshita, Yoshikazu, additional, Ishihara, Shunji, additional, and Isomoto, Hajime, additional

Published
2022
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11. Subtype of Achalasia and Integrated Relaxation Pressure Measured Using the Starlet High-resolution Manometry System: A Multicenter Study in Japan

Author

Tatsuta, Tetsuya, primary, Sato, Hiroki, additional, Fujiyoshi, Yusuke, additional, Abe, Hirofumi, additional, Shiwaku, Akio, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Ominami, Masaki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Fukuda, Shinsaku, additional, and Inoue, Haruhiro, additional

Published
2022
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12. Risks of refractory chest pain after peroral endoscopic myotomy in achalasia-related esophageal motility disorders: short-term results from a multicenter study in Japan

Author

Fukuda, Hisashi, primary, Sato, Hiroki, additional, Fujiyoshi, Yusuke, additional, Abe, Hirofumi, additional, Okada, Hiroki, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Sakae, Hiroyuki, additional, Ominami, Masaki, additional, Hata, Yoshitaka, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Yamamoto, Hironori, additional, and Inoue, Haruhiro, additional

Published
2022
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14. Efficacy of peroral endoscopic myotomy for esophageal motility disorders after gastric surgery: Japan Achalasia Multicenter Study

Author

Nakamura, Jun, primary, Sato, Hiroki, additional, Onimaru, Manabu, additional, Abe, Hirofumi, additional, Shiwaku, Hironari, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Sakae, Hiroyuki, additional, Ominami, Masaki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Takuto, Hikichi, additional, and Inoue, Haruhiro, additional

Published
2022
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15. Risk scoring system for the preprocedural prediction of the clinical failure of peroral endoscopic myotomy: a multicenter case–control study

Author

Abe, Hirofumi, additional, Tanaka, Shinwa, additional, Sato, Hiroki, additional, Shimamura, Yuto, additional, Okada, Hiroki, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Sakae, Hiroyuki, additional, Ominami, Masaki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, and Inoue, Haruhiro, additional

Published
2022
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18. Objective Methods of 5-Aminolevulinic Acid-Based Endoscopic Photodynamic Diagnosis Using Artificial Intelligence for Identification of Gastric Tumors

Author

Yamashita, Taro, primary, Kurumi, Hiroki, additional, Fujii, Masashi, additional, Sakaguchi, Takuki, additional, Hashimoto, Takeshi, additional, Kinoshita, Hidehito, additional, Kanda, Tsutomu, additional, Onoyama, Takumi, additional, Ikebuchi, Yuichiro, additional, Yoshida, Akira, additional, Kawaguchi, Koichiro, additional, Yashima, Kazuo, additional, and Isomoto, Hajime, additional

Published
2022
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21. Risk scoring system for the preprocedural prediction of the clinical failure of peroral endoscopic myotomy: a multicenter case–control study.

Author

Abe, Hirofumi, Tanaka, Shinwa, Sato, Hiroki, Shimamura, Yuto, Okada, Hiroki, Shiota, Junya, Sato, Chiaki, Sakae, Hiroyuki, Ominami, Masaki, Hata, Yoshitaka, Fukuda, Hisashi, Ogawa, Ryo, Nakamura, Jun, Tatsuta, Tetsuya, Ikebuchi, Yuichiro, Yokomichi, Hiroshi, and Inoue, Haruhiro

Subjects
DISEASE risk factors, LOG-rank test, MYOTOMY, DECISION making, CASE-control method, FORECASTING
Abstract

Background Peroral endoscopic myotomy (POEM) is effective for the management of achalasia and its variants; however, it can be ineffective in some patients. We aimed to develop and validate a risk scoring system to predict the clinical failure of POEM preoperatively. Methods Consecutive patients who underwent POEM in 14 high volume centers between 2010 and 2020 were enrolled in this study. Clinical failure was defined as an Eckardt score of ≥ 4 or retreatment. A risk scoring system to predict the short-term clinical failure of POEM was developed using multivariable logistic regression and internally validated using bootstrapping and decision curve analysis. Results Of the 2740 study patients, 112 (4.1 %) experienced clinical failure 6 months after POEM. Risk scores were assigned for three preoperative factors as follows: preoperative Eckardt score (1 point), manometric diagnosis (−4 points for type II achalasia), and a history of prior treatments (1 point for pneumatic dilation or 12 points for surgical/endoscopic myotomy). The discriminative capacity (concordance statistics 0.68, 95 %CI 0.62–0.72) and calibration (slope 1.15, 95 %CI 0.87–1.40) were shown. Decision curve analysis demonstrated its clinical usefulness. Patients were categorized into low (0–8 points; estimated risk of clinical failure < 5 %) and high risk (9–22 points; ≥ 5 %) groups. The proportions of clinical failure for the categories were stratified according to the mid-term outcomes (log-rank test, P < 0.001). Conclusions This risk scoring system can predict the clinical failure of POEM preoperatively and provide useful information when making treatment decisions. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Development of Dilated Esophagus, Sigmoid Esophagus, and Esophageal Diverticulum in Patients With Achalasia: Japan Achalasia Multicenter Study

Author

Sato, Hiroki, primary, Fujiyoshi, Yusuke, additional, Abe, Hirofumi, additional, Shiwaku, Hironari, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Sakae, Hiroyuki, additional, Ominami, Masaki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Terai, Shuji, additional, and Inoue, Haruhiro, additional

Published
2022
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23. Correction: Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy: A large-scale multicenter cohort study in Japan

Author

Shiwaku, Hironari, additional, Sato, Hiroki, additional, Shimamura, Yuto, additional, Abe, Hirofumi, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Ominami, Masaki, additional, Sakae, Hiroyuki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Hasegawa, Suguru, additional, and Inoue, Haruhiro, additional

Published
2022
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24. Risk factors and long-term course of gastroesophageal reflux disease after peroral endoscopic myotomy: A large-scale multicenter cohort study in Japan

Author

Shiwaku, Hironari, additional, Sato, Hiroki, additional, Shimamura, Yuto, additional, Abe, Hirofumi, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Ominami, Masaki, additional, Sakae, Hiroyuki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Hasegawa, Suguru, additional, and Inoue, Haruhiro, additional

Published
2022
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25. Esophageal carcinoma in achalasia patients managed with endoscopic submucosal dissection and peroral endoscopic myotomy: Japan Achalasia Multicenter Study

Author

Sato, Hiroki, primary, Nishikawa, Yohei, additional, Abe, Hirofumi, additional, Shiwaku, Hironari, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Sakae, Hiroyuki, additional, Ominami, Masaki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Terai, Shuji, additional, and Inoue, Haruhiro, additional

Published
2021
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27. Impact of the COVID‐19 pandemic on high‐resolution manometry and peroral endoscopic myotomy for esophageal motility disorder in Japan

Author

Ominami, Masaki, primary, Sato, Hiroki, additional, Fujiyoshi, Yusuke, additional, Abe, Hirofumi, additional, Shiwaku, Hironari, additional, Shiota, Junya, additional, Sato, Chiaki, additional, Sakae, Hiroyuki, additional, Hata, Yoshitaka, additional, Fukuda, Hisashi, additional, Ogawa, Ryo, additional, Nakamura, Jun, additional, Tatsuta, Tetsuya, additional, Ikebuchi, Yuichiro, additional, Yokomichi, Hiroshi, additional, Fujiwara, Yasuhiro, additional, and Inoue, Haruhiro, additional

Published
2021
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33. Esophageal carcinoma in achalasia patients managed with endoscopic submucosal dissection and peroral endoscopic myotomy: Japan Achalasia Multicenter Study.

Author

Sato, Hiroki, Nishikawa, Yohei, Abe, Hirofumi, Shiwaku, Hironari, Shiota, Junya, Sato, Chiaki, Sakae, Hiroyuki, Ominami, Masaki, Hata, Yoshitaka, Fukuda, Hisashi, Ogawa, Ryo, Nakamura, Jun, Tatsuta, Tetsuya, Ikebuchi, Yuichiro, Yokomichi, Hiroshi, Terai, Shuji, and Inoue, Haruhiro

Subjects
ESOPHAGEAL achalasia, ESOPHAGEAL motility disorders, MYOTOMY, ALCOHOL, ENDOSCOPIC surgery, ALCOHOL drinking
Abstract

Objectives: Indications for peroral endoscopic myotomy (POEM) and endoscopic submucosal dissection (ESD) in patients with achalasia concomitant with esophageal carcinoma (EC) are unclear. This study aimed to clarify the role of POEM in cases of achalasia concomitant with EC and to elucidate the indications for ESD and efficient surveillance for EC. Methods: We conducted a multicenter cohort study at 14 hospitals in Japan, including 3707 cases of achalasia‐related esophageal motility disorders (EMDs). Factors contributing to EC risk, the characteristics of EC, and clinical outcomes of POEM/ESD were analyzed. Results: In patients undergoing POEM, screening and surveillance endoscopy throughout a 1‐year period resulted in diagnosis of 72.1% new EC cases. Of 62 patients with 123 ECs, 40.3% had multiple or metachronous lesions within 37.5 months. EC was predominantly observed in the middle thoracic esophagus (58.5%) and posteriorly (73.2%). POEM had comparable safety and efficacy in cases of concomitant EC even after ESD. Endoscopic en bloc resection was performed in 95.8% and 89.3% of ECs diagnosed before and after POEM, respectively (P = 0.351); however, ESD on the POEM‐line was impaired by fibrosis. Multivariate analysis revealed risk factors for EC, including regular alcohol consumption, a history of smoking, advanced age, and extended disease duration. Alcohol intake and smoking had a synergistic effect on EC development. Conclusions: Screening and surveillance of POEM help in detecting EC. ESD is feasible in achalasia, although on the POEM‐line is challenging. Surveillance endoscopy for EC is recommended for cases with specific risks and a history of ECs. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Impact of the COVID‐19 pandemic on high‐resolution manometry and peroral endoscopic myotomy for esophageal motility disorder in Japan.

Author

Ominami, Masaki, Sato, Hiroki, Fujiyoshi, Yusuke, Abe, Hirofumi, Shiwaku, Hironari, Shiota, Junya, Sato, Chiaki, Sakae, Hiroyuki, Hata, Yoshitaka, Fukuda, Hisashi, Ogawa, Ryo, Nakamura, Jun, Tatsuta, Tetsuya, Ikebuchi, Yuichiro, Yokomichi, Hiroshi, Fujiwara, Yasuhiro, and Inoue, Haruhiro

Subjects
COVID-19, ESOPHAGEAL motility disorders, ESOPHAGEAL motility, COVID-19 pandemic, MYOTOMY, PERSONAL protective equipment
Abstract

Aim: To elucidate the impact of the coronavirus disease 2019 (COVID‐19) on the practice of high‐resolution manometry (HRM) and peroral endoscopic myotomy (POEM) in Japan. Methods: We utilized a large‐scale database involving 14 high‐volume centers in Japan to investigate changes in the numbers of HRM and POEM procedures performed and outcomes of POEM between 2019 and 2020. A questionnaire survey was also conducted to analyze pandemic‐associated changes in the HRM and POEM protocols. Results: Compared to that in 2019, the number of HRM and POEM procedures decreased by 17.2% (1587–1314) and 20.9% (630–498), respectively. These declines were prominent during the state of emergency from April to May 2020, particularly in pandemic areas. HRM and POEM in nonpandemic areas were relatively unaffected. From 2019 to 2020, there was a 0.4% (254–248) decrease in POEM cases within the prefecture, but the number outside the prefecture decreased by 33.6% (372–247). During the pandemic, the safety and efficacy of POEM were maintained. The implementation of personal protective equipment (PPE) measures varied among facilities, and PPE for POEM was relatively insufficient compared to that for HRM. Conclusion: The COVID‐19 pandemic influenced HRM and POEM practices in Japan. It is necessary to establish a sufficient system for HRM and POEM in each hospital as well as countrywide to overcome the effects of the pandemic. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Efficacy and Safety of a Novel Mouthpiece for Esophagogastroduodenoscopy: A Multi-Center, Randomized Study

Author

Ikebuchi, Yuichiro, primary, Matsumoto, Kazuya, additional, Ueda, Naoki, additional, Yamashita, Taro, additional, Kurumi, Hiroki, additional, Onoyama, Takumi, additional, Takeda, Yohei, additional, Yoshida, Akira, additional, Kawaguchi, Koichiro, additional, Yashima, Kazuo, additional, Fujiwara, Kazunori, additional, Imamoto, Ryu, additional, Noma, Hisashi, additional, Ueki, Masaru, additional, and Isomoto, Hajime, additional

Published
2021
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40. Autophagy‑related 16‑like 1 is influenced by human&nbsp;herpes virus 1‑encoded microRNAs in biopsy samples from the lower esophageal sphincter muscle during per‑oral endoscopic myotomy for esophageal achalasia

Author

Kanda, Tsutomu, primary, Yoshida, Akira, additional, Ikebuchi, Yuichiro, additional, Ikeda, Haruo, additional, Sakaguchi, Takuki, additional, Urabe, Shigetoshi, additional, Minami, Hitomi, additional, Nakao, Kazuhiko, additional, Inoue, Haruhiro, additional, and Isomoto, Hajime, additional

Published
2020
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42. Verteporfin‑photodynamic therapy is effective on gastric cancer cells

Author

Mae, Yukari, primary, Kanda, Tsutomu, additional, Sugihara, Takaaki, additional, Takata, Tomoaki, additional, Kinoshita, Hidehito, additional, Sakaguchi, Takuki, additional, Hasegawa, Takashi, additional, Tarumoto, Ryohei, additional, Edano, Mirai, additional, Kurumi, Hiroki, additional, Ikebuchi, Yuichiro, additional, Kawaguchi, Koichiro, additional, and Isomoto, Hajime, additional

Published
2020
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45. Identification of human herpes virus 1 encoded microRNAs in biopsy samples of lower esophageal sphincter muscle during peroral endoscopic myotomy for esophageal achalasia

Author

Ikebuchi, Yuichiro, primary, Kanda, Tsutomu, additional, Ikeda, Haruo, additional, Yoshida, Akira, additional, Sakaguchi, Takuki, additional, Urabe, Shigetoshi, additional, Minami, Hitomi, additional, Nakao, Kazuhiko, additional, Kuwamoto, Satoshi, additional, Inoue, Haruhiro, additional, and Isomoto, Hajime, additional

Published
2019
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50. Sa1303 – The Effect of Talaporfin-Mediated Photodynamic Therapy is Influenced by the Levels of Low-Density Lipoprotein Receptor Expression

Author

Kanda, Tsutomu, primary, Sugihara, Takaaki, additional, Takata, Tomoaki, additional, Mae, Yukari, additional, Sakaguchi, Takuki, additional, Kinoshita, Hidehito, additional, Yamashita, Taro, additional, Kurumi, Hiroki, additional, Ikebuchi, Yuichiro, additional, Kawaguchi, Koichiro, additional, Yashima, Kazuo, additional, and Isomoto, Hajime, additional

Published
2019
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