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221 results on '"Ikeda, Fumiaki"'

20. Broad spectrum in vitro microbicidal activity of benzoyl peroxide against microorganisms related to cutaneous diseases.

Author

Okamoto, Kazuaki, Kanayama, Shoji, Ikeda, Fumiaki, Fujikawa, Koki, Fujiwara, Shiori, Nozawa, Naoki, Mori, Sachi, Matsumoto, Tatsumi, Hayashi, Naoki, and Oda, Masataka

Abstract

The in vitro microbicidal activity of benzoyl peroxide against Cutibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Malassezia furfur, Malassezia restricta, and Malassezia globosa was investigated. These strains were incubated for 1 h in the presence of 0.25, 0.5, 1, or 2 mmol/L benzoyl peroxide in phosphate buffered saline supplemented with 0.1% glycerol and 2% Tween 80. After exposure to benzoyl peroxide, counts of viable Gram‐positive bacteria and fungi were markedly decreased, whereas counts of Gram‐negative bacteria were unchanged. Transmission electron microscopy images showed a decrease in electron density and the destruction of C. acnes and M. restricta cell walls after exposure to 2 mmol/L benzoyl peroxide. In conclusion, this study showed that benzoyl peroxide has a potent and rapid microbicidal activity against Gram‐positive bacteria and fungi that are associated with various cutaneous diseases. This suggests that the direct destruction of bacterial cell walls by benzoyl peroxide is an essential mechanism of its rapid and potent microbicidal activity against microorganisms. [ABSTRACT FROM AUTHOR]

Published
2021
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23. Zyvox® Annual Appraisal of Potency and Spectrum program: linezolid surveillance program results for 2008

Author

John D. Turnidge, Uchino Utsuki, Intetsu Kobayashi, Ronald N. Jones, Ikeda Fumiaki, James E. Ross, and Jan M. Bell

Subjects
Microbiology (medical), Canada, Asia, Microbial Sensitivity Tests, Drug resistance, Gram-Positive Bacteria, medicine.disease_cause, Enterococcus faecalis, Microbiology, chemistry.chemical_compound, Acetamides, Drug Resistance, Bacterial, Prevalence, medicine, Humans, Point Mutation, Gram-Positive Bacterial Infections, Oxazolidinones, Antibacterial agent, biology, Broth microdilution, Linezolid, General Medicine, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Anti-Bacterial Agents, Europe, RNA, Bacterial, RNA, Ribosomal, 23S, Latin America, Infectious Diseases, chemistry, Staphylococcus aureus, Vancomycin, medicine.drug, Enterococcus faecium
Abstract

The seventh year of the Zyvox® Annual Appraisal of Potency and Spectrum Program (2008) continues to monitor the in vitro activities of linezolid and comparator agents tested against Gram-positive pathogens in Latin America, Europe, Canada, and the Asia-Pacific region. Linezolid is an oxazolidinone approved for the treatment of vancomycin-resistant Enterococcus faecium infections, complicated skin and soft tissue infections, and nosocomial pneumonia caused by various Gram-positive species including methicillin-resistant Staphylococcus aureus (MRSA). Surveillance isolates were submitted from 64 medical centers (24 countries) for a total of 6121 strains. Each country was requested to send 200 consecutive isolates in 6 targeted pathogen categories to a central processing laboratory, except the United Kingdom, Japan, and China where more strains were processed (400, 400, and 800, respectively). Reference broth microdilution susceptibility testing methods were used to test the following organism groups: S. aureus (3240), coagulase-negative staphylococci (CoNS) (748), enterococci (864), Streptococcus pneumoniae (655), viridans group (297), and β-hemolytic streptococci (317). Eight linezolid-resistant (LZD-R) isolates were detected in 7 countries (Italy [2], France, China, Brazil, Sweden, Germany, and United Kingdom) among the enterococci ( Enterococcus faecalis [3] and E. faecium [2]) and CoNS (3 Staphylococcus epidermidis ). Five LZD-R isolates contained 23S rRNA mutations (G2576T or G2447T), and 2 strains had undeterminable resistance mechanisms. One CoNS (Italy) contained the mobile cfr gene. Vancomycin-resistant enterococci rates ranged from 0.0% in several countries to 59.4% in Taiwan. All streptococci were linezolid susceptible (MIC 90 , 1 μg/mL). In conclusion, the activity of linezolid remained uniform and stable across the sampled geographic regions studied when compared to the 2006 to 2007 results. Documented LZD-R remains rare (only 0.13% overall but highest for CoNS [0.41%] and enterococci [0.69%]) among the 24 countries sampled for the 6 different pathogen groups. Rates of clindamycin resistance and the frequency of MRSA varied by geographic region and between nations; therefore, like oxazolidinones, it requires continued surveillance for changing resistance patterns.

Published
2009

25. Suppressive effect and persistence of hygienic acaricides for control of ticks in recreational areas

Author

Hashimoto, Tomoyuki, primary, Minagawa, Keiko, additional, Kazuma, Tohru, additional, Muto, Atsuhiko, additional, Kasai, Shinji, additional, Komagata, Osamu, additional, Maekawa, Yoshihide, additional, Tomita, Takashi, additional, Watanabe, Mamoru, additional, Sawabe, Kyoko, additional, Shiraishi, Miyako, additional, Ohishi, Hideaki, additional, Yamauchi, Takeo, additional, Igarashi, Masato, additional, and Ikeda, Fumiaki, additional

Published
2017
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29. Field evaluation of suppression effect of acaricide formulations against ticks

Author

HASHIMOTO, Tomoyuki, primary, KAZUMA, Tohru, additional, MUTO, Atsuhiko, additional, MINAGAWA, Keiko, additional, NAGAHIRO, Kana, additional, TOYAMA, Keisuke, additional, ADACHI, Masaya, additional, IKEDA, Fumiaki, additional, KOMAGATA, Osamu, additional, TOMITA, Takashi, additional, MORI, Shigeru, additional, and SAWABE, Kyoko, additional

Published
2015
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