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6. AB1265 ANALYSIS OF CLINICAL OUTCOMES IN EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA) TREATED WITH MEPOLIZUMAB OVER 2 YEARS FOR REMISSION INDUCTION OR MAINTENANCE: A SINGLE CENTER EXPERIENCE IN JAPAN

Author

Komagata, Y., primary, Kawashima, S., additional, Yokota, R., additional, Hibino, T., additional, Date, Y., additional, Usui, K., additional, Yamamoto, J., additional, Ayuzawa, N., additional, Ikegaya, N., additional, Kawakami, T., additional, Kishimoto, M., additional, and Kaname, S., additional

Published
2024
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20. Association between age at disease onset of anti-neutrophil cytoplasmic antibody-associated vasculitis and clinical presentation and short-term outcomes

Author

Monti, S., Craven, A., Klersy, C., Montecucco, C., Caporali, R., Watts, R., Merkel, P. A., Luqmani, R., Achilleos, K., Adler, M., Alba, M. A., Albert, D. A., Alibaz-Oner, F., Allcoat, P., Amano, K., Amarasuriya, M., Amudala, N. A., Andrews, J., Archer, A. M., Arimura, Y., Atukorala, I., Azevedo, E., Bajad, S., Baldwin, C., Barra, L. J., Baslund, B., Basu, N., Baykal, M., Berger, C., Berglin, E., Besada, E., Bhardwaj, M., Bischof, A., Blockmans, D., Blood, J., Draibe, J. B., Brand, S., Brandao, M., Bruce, I. N., Butler, A., Calabrese, L. H., Ferrer, D. C., Carette, S., Carmona, D., Ceunen, H., Chakravarty, K., Chapman, P. T., Chocova, Z., Chung, S. A., Ci, W., Cid, M. C., Clark, T. M., Clarkson, M. R., De Jesus Contreras-Rodriguez, F., Conway, R., Cooke, K., Viros, X. C., Cordeiro, A., Costa, A., Culfear, K., Daikeler, T., Danda, D., Das, S. K., Dasgupta, B., De Castro, A. M., Dehghan, N., Devassy, R., Dhindsa, N., Diamantopoulos, A. P., Direskeneli, H., Dobashi, H., Juan, D., Durrani, M., Edelsten, C., Eifert, J., Elhayek, S., Elsideeg, S., Endo, T., Erden, A., Erer, B., Eriksson, P., Erturk, Z., Espigol-Frigole, G., Felicetti, M., Ferraro, A., Ferro, J. M., Fifi-Mah, A., Flores-Suarez, L. F., Flossmann, O., Flynn, D., Fonseca, J. E., Foot, J., Foote, M., Forbess, L., Fujimoto, S., Fukuoka, K., Furtado, C., Furuta, S., Gaffo, A. L., Gallagher, P., Gao, N., Gatenby, P., Gendi, N., Geraldes, R., Gerits, A., Gioffredi, A., Gomples, L., Goncalves, M. J., Gondo, P., Graham, A., Grainger, R., Gray, D. T., Grayson, P. C., Griffiths, L., Guo, Y., Gupta, R., Gylling, M., Hajj-Ali, R. A., Hammam, N., Harigai, M., Hartley, L., Haslett, J., Hassan, A., Hatemi, G., Hellmich, B., Henckaerts, L., Henes, J. C., Hepburn, J., Herd, V., Hess, C., Hill, C., Hinojosa-Azaola, A., Hirahashi, J., Hirano, F., Hocevar, A., Holle, J., Hollinger, N., Homma, S., Howard, T., Hoyles, R. K., Hruskova, Z., Hutcheon, G., Ignacak, M., Igney-Oertel, A., Ikeda, K., Ikegaya, N., Jagadeesh, S., Jaquith, J., Jayne, D. R. W., Jewell, T., Jones, C., Joshi, A., Kalyoncu, U., Kamall, S., Kamath, S., Lai, K. S., Kaname, S., Kanchinadham, S., Karadag, O., Karube, M., Kaszuba, M., Kaur, R., Kawakami, T., Kawashima, S., Khalidi, N., Khan, A., Kikuchi, M., Kilic, L., Kimura, M., King, M. J., Klapa, S., Klocke, R., Kobayashi, T., Kobayashi, S., Komagata, Y., Kronbichler, A., Kuczia, P., Kumar, M. S., Kurosawa, M., Lamprecht, P., Langford, C. A., Lanyon, P., Laversuch, C., Lee, S. J., Leoni, S., Li, J., Liang, K., Liang, P., Liao, H., Lee, L. A., Luqmani, R. A., Lyle, A., Macdonald, M., Mackie, S. L., Madden, L., Magliano, M., Makino, H., Makol, A., Malaiya, R., Malaviya, A., Manthri, R., Maritati, F., Da Silva, A. M., Mason, J. C., Matara, C., Matsui, K., Matteson, E. L., Mcbride, D., Mccullough, K., Mcgeoch, L., Mclaren, J., Mcmillian, C., Mendiratta, N., Menon, A., Merinopoulos, D., Merkel, P., Messier, S., Micheletti, R. G., Mills, K., Milman, N., Minoda, M., Minz, R. W., Mock, C., Mohammad, A. J., Moiseev, S., Moitinho, M., Molloy, E., Monach, P. A., Montgomery, M., Moosig, F., Moradizadeh, M., Morgan, M., Morgan, A. W., Morgan, A. -M., Muir, A., Mukhtyar, C., Muller, A., Muratore, F., Muso, E., Nada, R., Nakajima, H., Nakajima, T., Nakano, H., Nandagudi, A., Neumann, T., Y. F., Ng, K. H., Ng, Nogueira, E. L., Nolkha, N., Nordstrom, D., Novikov, P., Nugaliyadde, A., O'Donnell, J. L., O'Donoghue, J., O'Neill, L., O'Riordan, E., Oatley, M., Okubo, K., Oliva, E., Oshikawa, H., Ota, Y., Padoan, R., Pagnoux, C., Pan, L., Panaritis, K., Park, J. K., Patel, S., Patil, P., Pazzola, G., Peall, A., Pearce, F., Pehlevan, S., Pereira, L., Pettersson, T., Pineau, C. A., Pirila, L., Poglodek, B., Ponte, C., Prieto-Gonzalez, S., Priya, S. R., Purewal, B., Purschke, S., Putaala, J., Quickert, S., Quincey, V., Raghuvanshi, S., Rajasekhar, L., Ranganathan, D., Rathi, M., Rees, D., Rees, F., Renken, U., Restuccia, G., Rhee, R. L., Rice, B., Robins, D., Robson, J., Rodrigues, M., Romao, V. C., Rotar, C., Ruediger, C., Rutgers, A., A. C., Sa, Saavedra, M. J., Sada, K. -E., Sahbudin, I., Salvarani, C., Sandhu, N., Santos, E., Sato, Y., Schafer, V. S., Schiavon, F., Schmidt, W. A., Segelmark, M., Shahin, A., Sharma, A., Shotton, J., Silva, C., Singer, O. G., Sivasuthan, G., Smolen, S., Solanich-Moreno, X., Boixader, L. S., Song, Y. W., Springer, J., Sreih, A. G., Srivastava, R., Stamp, L. K., Stevens, R., Strbian, D., Sugino, K., Sunderkotter, C., Suppiah, R., Suzuki, K., Szekanecz, Z., Sznajd, J., Taimen, K., Tak, P. P., Takeuchi, T., Takizawa, N., Tames, L., Tan, B. E., Tanaka, M., Tang, M. W., Tatlisumak, T., Tesar, V., Thomas, A., Tian, X., Tokunaga, K., Tombetti, E., Tomsic, M., Toz, B., Tsukamoto, T., Uchida, S., Unal, A. U., Urban, M. L., Usui, J., Vaglio, A., Venkatachalam, S., Vermaak, E., Viswanath, V., Wada, T., Wagh, S., Wallace, D. J., Walters, G., Walz, B., Wan, J., Wang, T., Wang, G., Warrington, K. J., Watts, R. A., Wawrzycka-Adamczyk, K., Weeratunga, P., Weisman, M. H., Wickramasinghe, S., Williams, M., Wojcik, K., Woodruff, L., Xenitidis, T., Yamada, H., Yamagata, K., Yee, C. -S., Yoon, M., Yoshida, K., Yoshifuji, H., Ytterberg, S. R., Yumura, W., Zayed, H., Zeng, X., Zhao, M. -H., Zugaj, A., Zuk, J., İç Hastalıkları, Clinical Haematology, and Translational Immunology Groningen (TRIGR)

Subjects
Male, Outcome, Antineutrophil Cytoplasmic, 030232 urology & nephrology, 0302 clinical medicine, Risk Factors, 80 and over, Pharmacology (medical), Age of Onset, Young adult, Aged, 80 and over, education.field_of_study, age, anti-neutrophil cytoplasmic antibody-associated vasculitis, outcome, Adolescent, Adult, Aged, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, Antibodies, Antineutrophil Cytoplasmic, Female, Humans, Middle Aged, Morbidity, Prognosis, Retrospective Studies, Risk Assessment, Survival Rate, United Kingdom, Young Adult, Vasculitis, Systemic vasculitis, medicine.medical_specialty, Population, anti-neutrophil cytoplasmic antibody–associated vasculitis, Antibodies, 03 medical and health sciences, Rheumatology, Internal medicine, medicine, education, Anti-neutrophil cytoplasmic antibody–associated vasculitis, Survival rate, Anti-neutrophil cytoplasmic antibody, 030203 arthritis & rheumatology, business.industry, Retrospective cohort study, medicine.disease, Age of onset, business
Abstract

Objectives ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- and older-onset patients are still incompletely understood. Methods We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. We divided the population according to age at diagnosis: Results A total of 1338 patients with AAV were included: 66% had disease onset at Conclusion Within 6 months of diagnosis of AAV, patients >65 years of age display a different pattern of organ involvement and an increased risk of significant damage and mortality compared with younger patients.

Published
2021
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29. Radiologic and Pathologic Features of the Transmantle Sign in Focal Cortical Dysplasia: The T1 Signal Is Useful for Differentiating Subtypes

Author

Kimura, Yukio, primary, Shioya, A., additional, Saito, Y., additional, Oitani, Y., additional, Shigemoto, Y., additional, Morimoto, E., additional, Suzuki, F., additional, Ikegaya, N., additional, Kimura, Yuiko, additional, Iijima, K., additional, Takayama, Y., additional, Iwasaki, M., additional, Sasaki, M., additional, and Sato, N., additional

Published
2019
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34. Quantifying natural cross-ventilation flow of a two-layered model used for terraced houses in tropical zones by particle image velocimetry.

Author

Ali, N.M., Mohamad, M.F., Wang, W., Hirose, C., Yoshie, R., and Ikegaya, N.

Subjects
PARTICLE image velocimetry, WIND tunnels, VENTILATION, CLIMATIC zones, TROPICAL climate, NATURAL ventilation
Abstract

Wind-induced natural ventilation is a sustainable approach for improving the indoor thermal comfort, air quality, and energy consumption. Although numerous ventilation studies have addressed generic ventilation models, the cross-ventilation flow of a multilayered model (widely ingrained in a tropical climate zone such as Malaysia as a typical terraced house with a deep-plan layout) has not been studied well. Therefore, this study aims to investigate the flow patterns inside a simplified two-layered model separated by a second floor at the middle height with an opening using wind tunnel experiments. Two cases are considered based on the positions of the inlet and outlet openings on each floor. Two velocity components are measured using particle image velocimetry (PIV) and hot-wire anemometry (HWA). This study provides high-quality experimental datasets, which enables us to understand turbulent characteristics of indoor airflow, obtained using PIV and HWA for a generic two-layered cross-ventilation model. In addition, the results show that the ventilation performance of two-layered stratified buildings is significantly affected by the inlet opening positions. Moreover, the indoor flow direction is considerably changed owing to the multi-zoning of the indoor space. Although we employed only a generic two-layered model, this study clearly highlights the importance of considering multi-layered buildings for a better understanding of the ventilation performance. • Cross-ventilation flow patterns were measured for a generic two-layered model. • Flow directions were considerably changed owing to the multi-zone indoor space. • High-quality experimental datasets of cross ventilation were provided by PIV and HWA. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Ultrasound changes of the carpal tunnel in patients receiving long-term hemodialysis: a cross-sectional and longitudinal study

Author

Maruyama Y, Takita T, Akihiko Kato, Takahashi M, Takahashi T, Hishida A, and Ikegaya N

Subjects
Adult, Male, medicine.medical_specialty, Diabetic neuropathy, medicine.medical_treatment, Neural Conduction, Wrist, Nerve conduction velocity, Tendons, Renal Dialysis, medicine, Humans, Carpal tunnel, Longitudinal Studies, Carpal tunnel syndrome, Aged, Ultrasonography, Aged, 80 and over, business.industry, Ultrasound, General Medicine, Middle Aged, medicine.disease, Carpal Tunnel Syndrome, Median nerve, Surgery, Median Nerve, medicine.anatomical_structure, Cross-Sectional Studies, Nephrology, Ligaments, Articular, Disease Progression, Female, Hemodialysis, Nuclear medicine, business
Abstract

BACKGROUND Carpal tunnel syndrome (CTS) is one of the major problems of long-term hemodialysis (HD), but sometimes difficult to distinguish from uremic or diabetic neuropathy by clinical symptoms. PATIENTS AND METHODS To evaluate the diagnosis of CTS more precisely, we examined the ultrasonographic alterations of the carpal tunnel and tendons of 90 wrists from 45 patients undergoing HD for more than 5 years. We measured the thickness of the palmar radiocarpal ligament (PRL), corresponding to the posterior wall of the carpal tunnel (CT), and the width of the CT, and compared those values with sensory (SCV), motor conduction velocity (MCV) of the median nerve and clinical symptoms. In addition, we longitudinally measured CT and PRL in the same patients for 5 years, and compared ultrasonographic changes and clinical parameters. RESULTS A linear positive relationship was found between HD duration and PRL thickness (r = 0.43, p < 0.01) or CT width (r = 0.53, p < 0.01). CT diameter was negatively correlated with MCV (r = -0.30, p < 0.01) and SCV (r = -0.33, p < 0.04). PRL thickness was also inversely correlated with MCV (r = -0.44, p < 0.01) and SCV (r = -0.46, p < 0.01) of the median nerve, respectively. The wrists with clinical CTS and/or previous CTS surgery had significantly greater CT and PRL values compared to patients without CTS (CT: 6.1 0.2vs. 8.0+/-0.3 mm,p

Published
2002

37. Transfer and escape characteristics of outdoor pollutants into an indoor space sheltered by urban-like block arrays using large-eddy simulations

Author

Fernandez Ken Bryan, Ikegaya Naoki, and Ito Kazuhide

Subjects
Environmental sciences, GE1-350
Abstract

We conducted isothermal large-eddy simulations to generate the velocity and concentration distributions to investigate the air pollution transport from outside to inside of a space surrounded by urban-like block arrays. Contrary to previous study, we assumed that the pollution in the form of scalars are generated outdoors and not indoors which we placed at: 1) middle of window, 2) near window wall, 3) middle of street canyon at ground level, and 4) middle of street canyon at window level. Results showed that regardless of scalar source location, the scalars accumulated inside the indoor space which can be explained by the downdraft effect that are typically found in urban environments. The downdraft effect produced vortices outside and inside the indoor space. For scalars near window, indoor vortex drove the concentration to indoors. On the other hand, outdoor vortex transported the scalars located at street canyon to reach the window where they were eventually transported to indoors also due to indoor vortex. The average normalized indoor concentrations found in this study are 1.25 – 1.50, 1.00 – 1.75, 0.25 – 0.50, and 0.0 – 0.25 for scalars C1, C2, C3, and C4, respectively. Our study suggests that for natural ventilation studies of urban environments where air pollution is significant, outdoor effects should also be carefully considered.

Published
2023
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47. Immunoelectron microscopic study on type I, II and III TGF-beta receptors on visceral glomerular epithelial cells in relation to glomerular basement membrane alterations in proteinuric rats.

Author

Fujigaki, Y, Watanabe, T, Ikegaya, N, Yonemura, K, Sun, D F, Hishida, A, Yamamoto, T, Kojima, K, and Nagase, M

Abstract

Transforming growth factor (TGF)-beta is a regulator of extracellular matrix accumulation. Both TGF-beta receptors, type I (TbetaRI) and type II (TbetaRII), may be required for signal transduction in the TGF-beta pathway. The aim of this study was to investigate the relationship between the TGF-beta pathways and glomerular basement membrane (GBM) accumulation in vivo.

Published
2000
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