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4. Impact of a Cancer History on Cardiovascular Events Among Patients With Myocardial Infarction Who Received Revascularization

Author

Takeuchi, Taro, primary, Kosugi, Shumpei, additional, Ueda, Yasunori, additional, Ikeoka, Kuniyasu, additional, Yamane, Haruya, additional, Takayasu, Kohtaro, additional, Ohashi, Takuya, additional, Fukushima, Takashi, additional, Horiuchi, Kohei, additional, Iehara, Takashi, additional, Sakamoto, Mai, additional, Ukai, Kazuho, additional, Minami, Shinya, additional, Mizumori, Yuuki, additional, Muraoka, Naoya, additional, Nakamura, Masayuki, additional, Ozaki, Tatsuhisa, additional, Mishima, Tsuyoshi, additional, Abe, Haruhiko, additional, Inoue, Koichi, additional, and Matsumura, Yasushi, additional

Published
2023
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7. Temporary Rise in Blood Thrombogenicity in Patients with Acute Myocardial Infarction

Author

Kosugi, Shumpei, Ueda, Yasunori, Abe, Haruhiko, Ikeoka, Kuniyasu, Mishima, Tsuyoshi, Ozaki, Tatsuhisa, Takayasu, Kohtaro, Ohashi, Takuya, Yamane, Haruya, Nakamura, Masayuki, Fukushima, Takashi, Horiuchi, Kohei, Iehara, Takashi, Osaki, Satoshi, Ozato, Kazuki, Inoue, Koichi, Koretsune, Yukihiro, and Matsumura, Yasushi

Subjects
Economics and Econometrics, t-tas, blood thrombogenicity, RC666-701, Materials Chemistry, Media Technology, acute myocardial infarction, Diseases of the circulatory (Cardiovascular) system, Original Article, Forestry, coronary artery disease
Abstract

Objective Although blood thrombogenicity seems to be one of the determinant factors for the development of acute myocardial infarction (MI), it has not been dealt with in-depth. This study aimed to investigate blood thrombogenicity and its change in acute MI patients. Methods and Results We designed a prospective, observational study that included 51 acute MI patients and 83 stable coronary artery disease (CAD) patients who underwent cardiac catheterization, comparing thrombogenicity of the whole blood between: (1) acute MI patients and stable CAD patients; and (2) acute and chronic phase in MI patients. Blood thrombogenicity was evaluated by the Total Thrombus-Formation Analysis System (T-TAS) using the area under the flow pressure curve (AUC30) for the AR-chip. Acute MI patients had significantly higher AUC30 than stable CAD patients (median [interquartile range], 1,771 [1,585–1,884] vs. 1,677 [1,527–1,756], p = 0.010). Multivariate regression analysis identified acute MI with initial TIMI flow grade 0/1 as an independent determinant of high AUC30 (β = 0.211, p = 0.013). In acute MI patients, AUC30 decreased significantly from acute to chronic phase (1,859 [1,550–2,008] to 1,521 [1,328–1,745], p = 0.001). Conclusion Blood thrombogenicity was significantly higher in acute MI patients than in stable CAD patients. Acute MI with initial TIMI flow grade 0/1 was significantly associated with high blood thrombogenicity by multivariate analysis. In acute MI patients, blood thrombogenicity was temporarily higher in acute phase than in chronic phase.

Published
2022

8. Temporary Rise in Blood Thrombogenicity in Patients with Acute Myocardial Infarction

Author

Kosugi, Shumpei, additional, Ueda, Yasunori, additional, Abe, Haruhiko, additional, Ikeoka, Kuniyasu, additional, Mishima, Tsuyoshi, additional, Ozaki, Tatsuhisa, additional, Takayasu, Kohtaro, additional, Ohashi, Takuya, additional, Yamane, Haruya, additional, Nakamura, Masayuki, additional, Fukushima, Takashi, additional, Horiuchi, Kohei, additional, Iehara, Takashi, additional, Osaki, Satoshi, additional, Ozato, Kazuki, additional, Inoue, Koichi, additional, Koretsune, Yukihiro, additional, and Matsumura, Yasushi, additional

Published
2021
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14. Pressure- and Velocity-Based Physiological Assessment of Stenotic Lesions at Hyperemia in Superficial Femoral Artery Disease: Importance of Hyperemic Stenosis Resistance

Author

Ikeoka, Kuniyasu, primary, Watanabe, Tetsuya, additional, Shinoda, Yukinori, additional, Minamisaka, Tomoko, additional, Fukuoka, Hidetada, additional, Inui, Hirooki, additional, Ueno, Keisuke, additional, Inoue, Soki, additional, Mine, Kentaro, additional, and Hoshida, Shiro, additional

Published
2019
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23. A case of successful bystander cardiopulmonary resuscitation of an adult with Bland-White-Garland syndrome

Author

Fukuoka, Hidetada, primary, Watanabe, Tetsuya, additional, Shinoda, Yukinori, additional, Ikeoka, Kuniyasu, additional, Minamisaka, Tomoko, additional, Inui, Hirooki, additional, Ueno, Keisuke, additional, Inoue, Soki, additional, Mine, Kentaro, additional, Toda, Koichi, additional, Sawa, Yoshiki, additional, and Hoshida, Shiro, additional

Published
2017
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27. Sex‐related differences in left ventricular diastolic function and arterial elastance during admission in patients with heart failure with preserved ejection fraction: The PURSUIT HFpEF study.

Author

Hoshida, Shiro, Watanabe, Tetsuya, Shinoda, Yukinori, Ikeoka, Kuniyasu, Minamisaka, Tomoko, Fukuoka, Hidetada, Inui, Hirooki, Ueno, Keisuke, Suna, Shinichiro, Nakatani, Daisaku, Hikoso, Shungo, Yamada, Takahisa, Yasumura, Yoshio, Fuji, Hisakazu, Sakata, Yasushi, Tamaki, Shunsuke, Fukunami, Masatake, Hayashi, Takaharu, Takeda, Yasuharu, and Higuchi, Yoshiharu

Published
2018
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31. Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart

Author

Arita, Yoh, primary, Nakaoka, Yoshikazu, additional, Matsunaga, Taichi, additional, Kidoya, Hiroyasu, additional, Yamamizu, Kohei, additional, Arima, Yuichiro, additional, Kataoka-Hashimoto, Takahiro, additional, Ikeoka, Kuniyasu, additional, Yasui, Taku, additional, Masaki, Takeshi, additional, Yamamoto, Kaori, additional, Higuchi, Kaori, additional, Park, Jin-Sung, additional, Shirai, Manabu, additional, Nishiyama, Koichi, additional, Yamagishi, Hiroyuki, additional, Otsu, Kinya, additional, Kurihara, Hiroki, additional, Minami, Takashi, additional, Yamauchi-Takihara, Keiko, additional, Koh, Gou Y., additional, Mochizuki, Naoki, additional, Takakura, Nobuyuki, additional, Sakata, Yasushi, additional, Yamashita, Jun K., additional, and Komuro, Issei, additional

Published
2014
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33. Tocilizumab for the Treatment of Patients With Refractory Takayasu Arteritis

Author

Nakaoka, Yoshikazu, primary, Higuchi, Kaori, additional, Arita, Yoh, additional, Otsuki, Michio, additional, Yamamoto, Kaori, additional, Hashimoto-Kataoka, Takahiro, additional, Yasui, Taku, additional, Ikeoka, Kuniyasu, additional, Ohtani, Tomohito, additional, Sakata, Yasushi, additional, Shima, Yoshihito, additional, Kumanogoh, Atsushi, additional, Yamauchi-Takihara, Keiko, additional, Tanaka, Toshio, additional, Kishimoto, Tadamitsu, additional, and Komuro, Issei, additional

Published
2013
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34. Endothelial Gab1 Deletion Accelerates Angiotensin II-Dependent Vascular Inflammation and Atherosclerosis in Apolipoprotein E Knockout Mice

Author

Higuchi, Kaori, primary, Nakaoka, Yoshikazu, additional, Shioyama, Wataru, additional, Arita, Yoh, additional, Hashimoto, Takahiro, additional, Yasui, Taku, additional, Ikeoka, Kuniyasu, additional, Kuroda, Tadashi, additional, Minami, Takashi, additional, Nishida, Keigo, additional, Fujio, Yasushi, additional, Yamauchi-Takihara, Keiko, additional, Shirai, Mikiyasu, additional, Mochizuki, Naoki, additional, and Komuro, Issei, additional

Published
2012
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37. P-189 Low Right Atrial Septal Pacing Prevents Chronic Atrial Fibrillation in Patients with Sick Sinus Syndrome

Author

Minamiguchi, Hitoshi, primary, Watanabe, Tetsuya, additional, Nanto, Shinsuke, additional, Uematsu, Masaaki, additional, Morozumi, Takakazu, additional, Awata, Masaki, additional, Onishi, Toshinari, additional, Iida, Osamu, additional, Sera, Fusako, additional, Kawamoto, Kenji, additional, Yano, Masamichi, additional, Ikeoka, Kuniyasu, additional, Okamoto, Shin, additional, Tanaka, Nobuaki, additional, Yasui, Haruyo, additional, Ishihara, Takayuki, additional, Dohi, Tomoharu, additional, and Nagata, Seiki, additional

Published
2009
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39. Abstract 2566: Intravascular Ultrasound Guidance may Modify Neointimal Coverage Following Sirolimus-Eluting Stent Implantation

Author

Sera, Fusako, primary, Uematsu, Masaaki, additional, Kotani, Jun-ichi, additional, Awata, Masaki, additional, Morozumi, Takakazu, additional, Watanabe, Tetsuya, additional, Onishi, Toshinari, additional, Iida, Osamu, additional, Minamiguchi, Hitoshi, additional, Kawamoto, Kenji, additional, Yano, Masamichi, additional, Ikeoka, Kuniyasu, additional, Okamoto, Shin, additional, Tanaka, Nobuaki, additional, Yasui, Haruyo, additional, Ishihara, Takayuki, additional, Dohi, Tomoharu, additional, Nanto, Shinsuke, additional, and Nagata, Seiki, additional

Published
2008
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40. Abstract 6189: Stent Fracture does not Affect Long Term Patency in the Femoro-popliteal Artery: Four Years Experience

Author

Iida, Osamu, primary, Nanto, Shinsuke, additional, Uematsu, Masaaki, additional, Morozumi, Takakazu, additional, Watanabe, Tetsuya, additional, Awata, Masaki, additional, Onishi, Toshinari, additional, Sera, Fusako, additional, Minamiguchi, Hitoshi, additional, Yano, Masamichi, additional, Ikeoka, Kuniyasu, additional, Okamoto, Shin, additional, Tanaka, Nobuaki, additional, Yasui, Haruyo, additional, ishihara, Takayuki, additional, Dohi, Tomoharu, additional, and Nagata, Seiki, additional

Published
2008
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41. Abstract 4228: Objective Judgment in Dobutamine Stress Echocardiography: Visualization of Post-Systolic Shortening by Tissue Doppler Imaging

Author

Onishi, Toshinari, primary, Uematsu, Masaaki, additional, Tanaka, Nobuaki, additional, Nanto, Shinsuke, additional, Morozumi, Takakazu, additional, Watanabe, Tetsuya, additional, Awata, Masaki, additional, Iida, Osamu, additional, Kawamoto, Kenji, additional, Sera, Fusako, additional, Minamiguchi, Hitoshi, additional, Yano, Masamichi, additional, Ikeoka, Kuniyasu, additional, Okamoto, Shin, additional, Yasui, Haruyo, additional, Ishihara, Takayuki, additional, Dohi, Tomoharu, additional, and Nagata, Seiki, additional

Published
2008
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42. Abstract 2777: Optimal Expansion of the Stent is a Major Contributor to the Neointimal Coverage Following Sirolimus-eluting Stent Implantation: A Combined Study of Angioscopy and Intravascular Ultrasound

Author

Sera, Fusako, primary, Kotani, Jun-ichi, additional, Awata, Masaki, additional, Nanto, Shinsuke, additional, Uematsu, Masaaki, additional, Morozumi, Takakazu, additional, Watanabe, Tetsuya, additional, Onishi, Toshinari, additional, Iida, Osamu, additional, Minamiguchi, Hitoshi, additional, Akahori, Hirokuni, additional, Yano, Masamichi, additional, Ikeoka, Kuniyasu, additional, Okamoto, Shin, additional, Tanaka, Nobuaki, additional, Yasui, Haruyo, additional, and Nagata, Seiki, additional

Published
2007
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43. Abstract 2778: Incomplete Neointimal Coverage Two Years after Sirolimus-Eluting Stent Implantation: A Serial Angioscopic Follow-up Study

Author

Awata, Masaki, primary, Kotani, Jun-ichi, additional, Uematsu, Masaaki, additional, Morozumi, Takakazu, additional, Watanabe, Tetsuya, additional, Onishi, Toshinari, additional, Iida, Osamu, additional, Sera, Fusako, additional, Akahori, Hirokuni, additional, Yano, Masamichi, additional, Tanaka, Nobuaki, additional, Yasui, Haruyo, additional, Ikeoka, Kuniyasu, additional, Okamoto, Shin, additional, Nanto, Shinsuke, additional, and Nagata, Seiki, additional

Published
2007
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44. Influence of Stent Fracture on the Long-Term Patency in the Femoro-Popliteal Artery Experience of 4 Years

Author

Iida, Osamu, Nanto, Shinsuke, Uematsu, Masaaki, Ikeoka, Kuniyasu, Okamoto, Shin, and Nagata, Seiki

Subjects
femoro-popliteal artery, stent fracture, endovascular therapy, nitinol stent, equipment and supplies
Abstract

ObjectivesWe investigated the time course of stent patency in the femoro-popliteal artery for as long as 4 years.BackgroundStent fracture has been related to poor 2-year patency in the femoro-popliteal artery.MethodsWe studied 239 consecutive patients who underwent provisional de novo stenting with nitinol stents for 333 limbs (Luminexx stent [C. R. Bard, Inc., Murray Hill, New Jersey] in 91 limbs; Smart stent [Cordis Corp., Miami Lakes, Florida] in 242 limbs) from April 2004 to December 2007. Stent fracture was determined by X-ray with multiple projections. Patency was assessed by duplex ultrasonography as peak systolic velocity ratio

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45. Abstract 14752: Pressure- and Velocity-Based Physiological Assessment of Stenotic Lesions at Hyperemia in Superficial Femoral Artery Disease; Importance of Hyperemic Stenosis Resistance.

Author

Ikeoka, Kuniyasu, Nishikawa, Nagahiro, Watanabe, Tetusya, and Hoshida, Shiro

Subjects
*FEMORAL artery, *HYPEREMIA, *ARTERIAL diseases, *RECEIVER operating characteristic curves, *HEART failure, *PERIPHERAL vascular diseases, *STENOSIS
Abstract

Introduction: Measurement of the fractional flow reserve (FFR) or vascular flow reserve (VFR) is a feasible approach to diagnose a peripheral arterial physiological condition. However, maximal hyperemic response, leading to examination of Doppler flow velocity and stenosis resistance, in lower-limb lesions is not well understood. Hypothesis: We assessed the hypothesis that VFR and stenosis resistance predict stenosis severity in peripheral artery disease. Methods: Twenty four limbs (men 67%, age 74 years) with focal stenosis of the superficial femoral artery (SFA) were analyzed. We excluded critical limb ischemia, heart failure and hemodialysis patients. We measured average pressure and average peak velocity of SFA with a pressure/Doppler flow sensor-tipped combination guide wire. We assessed FFR, hyperemic stenosis resistance (h-SR) and VFR before and after endovascular therapy. h-SR was defined as the ratio of ΔP (stenotic segment average pressure gradient) to hyperemic average peak velocity. Hyperemia was induced with intra-arterial 20mg papaverine infusion. Results: Significant alterations were observed after endovascular therapy in FFR (from 0.81±0.12 to 0.97±0.06, p<0.01), h-SR (from 0.56±0.44 to 0.09±0.12 mmHg•sec/cm, p<0.01) and VFR (from 1.73±0.31 to 1.91±0.41, p<0.05) in focal SFA stenosis. h-SR was more strongly correlated with % area stenosis measured by intravascular ultrasound than FFR (h-SR: r=0.741, FFR: r=-0.716, p<0.001 each) before endovascular therapy. VFR was not associated with % area stenosis (r=0.120, n.s.). The cut-off points with h-SR >0.36 mmHg•sec/cm and FFR <0.88 predicted over 75% area stenosis with area under curves of 0.883 and 0.828, respectively, by a receiver operating characteristic curve analysis. Conclusions: h-SR can indicate the stenotic severity in SFA focal lesion and may be a more better physiological index to determine indication for endovascular treatment than FFR. On the other hand, VFR was not feasible for assessment in SFA focal stenosis. [ABSTRACT FROM AUTHOR]

Published
2018

46. Abstract 14674: Arrival Time Ratio of Below the Ankle as a Determinant Factor for Limb Salvage: Evaluation by Two Dimensional-Perfusion Angiography.

Author

Ikeoka, Kuniyasu, Nishikawa, Nagahiro, Watanabe, Tetusya, and Hoshida, Shiro

Subjects
*LIMB salvage, *RECEIVER operating characteristic curves, *ANKLE, *ANGIOGRAPHY
Abstract

Introduction: In patients with critical limb ischemia, it is desirable to keep lower limb skin perfusion pressure (SPP) ≥40 mmHg. Two dimensional (2D)-perfusion angiography is an evolving technique for quantitative tissue perfusion analysis. However, 2D-perfusion angiography analysis for below the knee (BK) is not established. Hypothesis: We assessed the hypothesis that 2D-perfusion angiographical parameters of lower limb are related to SPP after endovascular treatment (EVT) for BK lesions. Methods: We enrolled 31 limbs (mean age 74.8 years, men 70%) which underwent EVT for BK lesions. Twenty two limbs were critical limb ischemia. Severe tissue loss subjects as Rutherford category 6 were excluded. We quantified indexed blood flow by using 2D-perfusion angiography. Region of interest was placed on the below the ankle in the 2D perfusion image, and then parameters were analyzed by the graph of time and density. Six parameters [arrival time, time to peak, wash-in rate, width, area under the curve and mean transit time] were acquired after EVT. Hyperemia was induced by intra-arterial 20mg papaverine infusion. Results: Dorsal and plantar SPP were significantly correlated with hyperemic arrival time (dorsal: r=-0.42, P=0.032; plantar: r=-0.42, P=0.034), hyperemic wash-in rate (dorsal: r=-0.42, P=0.031; plantar: r=-0.45 P=0.020), and hyperemic/baseline arrival time ratio (dorsal: r=-0.58, P=0.0020; plantar: r=-0.40 P=0.044) of lower ankle regions after EVT. However, only arrival time ratio was independently associated with dorsal SPP in multivariate analysis after EVT (P=0.048). A receiver operating characteristic curve showed arrival time ratio < 0.86 predicted to obtain SPP levels ≥40 mmHg after EVT with an area under curve of 0.77 (95% confidence interval, 0.56-0.98). Conclusions: Arrival time ratio was an independent predictor for SPP levels after EVT. Arrival time ratio < 0.86 of lower ankle regions may be essential to obtain the minimum levels of SPP for limb salvage after BK intervention. 2D-pefusion imaging in hyperemic condition can be feasible to predict limb tissue perfusion after EVT. [ABSTRACT FROM AUTHOR]

Published
2018

47. Abstract 11650: Sex-Related Differences in Left Ventricular Diastolic Function and Arterial Elastance During Admission in Patients With Heart Failure With Preserved Ejection Fraction: The PURSUIT HFpEF Study.

Author

Hoshida, Shiro, Watanabe, Tetsuya, Shinoda, Yukinori, Ikeoka, Kuniyasu, Minamisaka, Tomoko, Fukuoka, Hidetada, Inui, Hirooki, Ueno, Keisuke, Suna, Shinichiro, Nakatani, Daisaku, Hikoso, Shungo, Yamada, Takahisa, Yasumura, Yoshio, Fuji, Hisakazu, and Sakata, Yasushi

Published
2018

48. Impact of a Cancer History on Cardiovascular Events Among Patients With Myocardial Infarction Who Received Revascularization.

Author

Takeuchi T, Kosugi S, Ueda Y, Ikeoka K, Yamane H, Takayasu K, Ohashi T, Fukushima T, Horiuchi K, Iehara T, Sakamoto M, Ukai K, Minami S, Mizumori Y, Muraoka N, Nakamura M, Ozaki T, Mishima T, Abe H, Inoue K, and Matsumura Y

Subjects
Humans, Retrospective Studies, Aftercare, Patient Discharge, Coronary Angiography, Treatment Outcome, Risk Factors, Myocardial Revascularization methods, Myocardial Infarction etiology, Percutaneous Coronary Intervention adverse effects, Neoplasms etiology
Abstract

Background: It remains controversial whether a cancer history increases the risk of cardiovascular (CV) events among patients with myocardial infarction (MI) who undergo revascularization.Methods and Results: Patients who were confirmed as type 1 acute MI (AMI) by coronary angiography were retrospectively analyzed. Patients who died in hospital or those not undergoing revascularization were excluded. Patients with a cancer history were compared with those without it. A cancer history was examined in the in-hospital cancer registry. The primary outcome was a composite of cardiac death, recurrent type 1 MI, post-discharge coronary revascularization, heart failure hospitalization, and stroke. Among 551 AMI patients, 55 had a cancer history (cancer group) and 496 did not (non-cancer group). Cox proportional hazards model revealed that the risk of composite endpoint was significantly higher in the cancer group than in the non-cancer group (adjusted hazard ratio [HR]: 1.78; 95% confidence interval [CI]: 1.13-2.82). Among the cancer group, patients who were diagnosed as AMI within 6 months after the cancer diagnosis had a higher risk of the composite endpoint than those who were diagnosed as AMI 6 months or later after the cancer diagnosis (adjusted HR: 5.43; 95% CI: 1.55-19.07)., Conclusions: A cancer history increased the risk of CV events after discharge among AMI patients after revascularization.

Published
2024
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