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1. Prognostic value of a composite physiologic index developed by adding bronchial and hyperlucent volumes quantified via artificial intelligence technology

Author

Uyama, Michihiro, Handa, Tomohiro, Uozumi, Ryuji, Hashimoto, Seishu, Taguchi, Yoshio, Ikezoe, Kohei, Tanizawa, Kiminobu, Tanabe, Naoya, Oguma, Tsuyoshi, Matsunashi, Atsushi, Niwamoto, Takafumi, Shima, Hiroshi, Mori, Ryobu, Maetani, Tomoki, Shiraishi, Yusuke, Nobashi, Tomomi W., Sakamoto, Ryo, Kubo, Takeshi, Yoshizawa, Akihiko, Terada, Kazuhiro, Nakamoto, Yuji, and Hirai, Toyohiro

Published
2024
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3. Prognosis of patients with systemic sclerosis-related interstitial lung disease on the lung transplant waiting list: a retrospective study

Author

Nakayama, Yoichi, Nakashima, Ran, Handa, Tomohiro, Ohsumi, Akihiro, Yamada, Yoshito, Nakajima, Daisuke, Yutaka, Yojiro, Tanaka, Satona, Hamada, Satoshi, Ikezoe, Kohei, Tanizawa, Kiminobu, Shirakashi, Mirei, Hiwa, Ryosuke, Tsuji, Hideaki, Kitagori, Koji, Akizuki, Shuji, Yoshifuji, Hajime, Date, Hiroshi, and Morinobu, Akio

Published
2023
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5. Lung function decline in sarcoidosis

Author

Tanizawa, Kiminobu, Handa, Tomohiro, Nagai, Sonoko, Ikezoe, Kohei, Kubo, Takeshi, Yokomatsu, Takafumi, Ueda, Seigen, Fushimi, Yasutaka, Ogino, Shumpei, Watanabe, Kizuku, Nakatsuka, Yoshinari, Hirai, Toyohiro, and Izumi, Takateru

Published
2022
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7. The transition from normal lung anatomy to minimal and established fibrosis in idiopathic pulmonary fibrosis (IPF)

Author

Xu, Feng, Tanabe, Naoya, Vasilescu, Dragos M., McDonough, John E., Coxson, Harvey O., Ikezoe, Kohei, Kinose, Daisuke, Ng, Kevin W., Verleden, Stijn E., Wuyts, Wim A., Vanaudenaerde, Bart M., Verschakelen, Johny, Cooper, Joel D., Lenburg, Marc E., Morshead, Katrina B., Abbas, Alexander R., Arron, Joseph R., Spira, Avrum, Hackett, Tillie-Louise, Colby, Thomas V., Ryerson, Christopher J., Ng, Raymond T., and Hogg, James C.

Published
2021
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9. Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma.

Author

Ikezoe, Kohei, Oga, Toru, Honda, Tetsuya, Hara-Chikuma, Mariko, Ma, Xiaojun, Tsuruyama, Tatsuaki, Uno, Kazuko, Fuchikami, Jun-Ichi, Tanizawa, Kiminobu, Handa, Tomohiro, Taguchi, Yoshio, Verkman, Alan S, Narumiya, Shuh, Mishima, Michiaki, and Chin, Kazuo

Subjects
Lymph Nodes, Spleen, CD4-Positive T-Lymphocytes, Macrophages, Alveolar, Bronchoalveolar Lavage Fluid, Animals, Mice, Inbred C57BL, Asthma, Pneumonia, Hypersensitivity, Hydrogen Peroxide, Ovalbumin, RNA, Messenger, Chemokines, Cell Count, Cell Membrane Permeability, Gene Expression Regulation, Aquaporin 3, Macrophages, Alveolar, Mice, Inbred C57BL, RNA, Messenger
Abstract

Oxidative stress plays a pivotal role in the pathogenesis of asthma. Aquaporin-3 (AQP3) is a small transmembrane water/glycerol channel that may facilitate the membrane uptake of hydrogen peroxide (H2O2). Here we report that AQP3 potentiates ovalbumin (OVA)-induced murine asthma by mediating both chemokine production from alveolar macrophages and T cell trafficking. AQP3 deficient (AQP3(-/-)) mice exhibited significantly reduced airway inflammation compared to wild-type mice. Adoptive transfer experiments showed reduced airway eosinophilic inflammation in mice receiving OVA-sensitized splenocytes from AQP3(-/-) mice compared with wild-type mice after OVA challenge, consistently with fewer CD4(+) T cells from AQP3(-/-) mice migrating to the lung than from wild-type mice. Additionally, in vivo and vitro experiments indicated that AQP3 induced the production of some chemokines such as CCL24 and CCL22 through regulating the amount of cellular H2O2 in M2 polarized alveolar macrophages. These results imply a critical role of AQP3 in asthma, and AQP3 may be a novel therapeutic target.

Published
2016

11. One-year lung function decline in sarcoidosis

Author

Tanizawa, Kiminobu, primary, Handa, Tomohiro, additional, Nagai, Sonoko, additional, Ikezoe, Kohei, additional, Kubo, Takeshi, additional, Yokomatsu, Takafumi, additional, Ueda, Seigen, additional, Fushimi, Yasutaka, additional, Ogino, Shumpei, additional, Hirai, Toyohiro, additional, and Izumi, Takateru, additional

Published
2024
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12. Evaluation of Bone Mineral Density in Lung Transplant Recipients by Chest Computed Tomography

Author

Mori, Ryobu, primary, Handa, Tomohiro, additional, Ohsumi, Akihiro, additional, Ikezoe, Kohei, additional, Tanizawa, Kiminobu, additional, Uozumi, Ryuji, additional, Tanabe, Naoya, additional, Oguma, Tsuyoshi, additional, Sakamoto, Ryo, additional, Hamaji, Masatsugu, additional, Nakajima, Daisuke, additional, Yutaka, Yojiro, additional, Tanaka, Satona, additional, Yamada, Yoshito, additional, Oshima, Yohei, additional, Sato, Susumu, additional, Fukui, Motonari, additional, Date, Hiroshi, additional, and Hirai, Toyohiro, additional

Published
2023
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14. The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies

Author

Tanizawa, Kiminobu, Handa, Tomohiro, Nakashima, Ran, Kubo, Takeshi, Hosono, Yuji, Watanabe, Kizuku, Aihara, Kensaku, Ikezoe, Kohei, Sokai, Akihiko, Nakatsuka, Yoshinari, Taguchi, Yoshio, Hatta, Kazuhiro, Noma, Satoshi, Kobashi, Yoichiro, Yoshizawa, Akihiko, Oga, Toru, Hirai, Toyohiro, Chin, Kazuo, Nagai, Sonoko, Izumi, Takateru, Mimori, Tsuneyo, and Mishima, Michiaki

Published
2017
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15. Evaluation of Bone Mineral Density in Lung Transplant Recipients by Chest Computed Tomography.

Author

Mori, Ryobu, Handa, Tomohiro, Ohsumi, Akihiro, Ikezoe, Kohei, Tanizawa, Kiminobu, Uozumi, Ryuji, Tanabe, Naoya, Oguma, Tsuyoshi, Sakamoto, Ryo, Hamaji, Masatsugu, Nakajima, Daisuke, Yutaka, Yojiro, Tanaka, Satona, Yamada, Yoshito, Oshima, Yohei, Sato, Susumu, Fukui, Motonari, Date, Hiroshi, and Hirai, Toyohiro

Subjects
GLUCOCORTICOIDS, CHEST X rays, SCIENTIFIC observation, DIPHOSPHONATES, LUNG transplantation, AGE distribution, PATIENTS, RETROSPECTIVE studies, OSTEOPOROSIS, SEX distribution, COMPRESSION fractures, PRE-tests & post-tests, OBSTRUCTIVE lung diseases, DESCRIPTIVE statistics, BONE density, COMPUTED tomography, SMOKING, TRANSPLANTATION of organs, tissues, etc., THORACIC vertebrae, DISEASE risk factors, DISEASE complications
Abstract

Introduction: Lung transplantation (LT) recipients are at risk of bone mineral density (BMD) loss. Pre- and post-LT BMD loss has been reported in some cross-sectional studies; however, there are limited studies regarding the serial BMD change in LT recipients. The aim of this study was to investigate the serial BMD changes and the clinical characteristics associated with BMD decline. Methods: This was a single-center, retrospective observational study. BMD was serially measured in thoracic vertebral bodies (Th4, 7, 10) using computed tomography (CT) before and 3 and 12 months after LT. The frequency of osteoporosis and factors associated with pre-LT osteoporosis and post-LT BMD loss were evaluated. The frequency of post-LT compression fracture and its associated factors were also analyzed. Results: This study included 128 adult LT recipients. LT recipients had decreased BMD (151.8 ± 42.2 mg/mL) before LT compared with age-, sex-, and smoking index-matched controls (176.2 ± 35.7 mg/mL). The diagnosis of COPD was associated with pre-LT osteoporosis. LT recipients experience further BMD decline after transplantation, and the percentage of recipients classified as exhibiting osteoporosis increased from 20% at baseline to 43% at 12 months. Recipients who had been taking no or small doses of glucocorticoids before LT had rapid BMD loss after LT. Early bisphosphonate use (within 3 months) after LT attenuated BMD loss and decreased new-onset compression fracture. Conclusion: LT recipients are at high risk for BMD loss and compression fracture after LT. Early bisphosphonate use may decrease BMD loss and compression fracture. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Clinical significance of radiological pleuroparenchymal fibroelastosis pattern in interstitial lung disease patients registered for lung transplantation: a retrospective cohort study

Author

Tanizawa, Kiminobu, Handa, Tomohiro, Kubo, Takeshi, Chen-Yoshikawa, Toyofumi F., Aoyama, Akihiro, Motoyama, Hideki, Hijiya, Kyoko, Yoshizawa, Akihiko, Oshima, Yohei, Ikezoe, Kohei, Tokuda, Shinsaku, Nakatsuka, Yoshinari, Murase, Yuko, Nagai, Sonoko, Muro, Shigeo, Oga, Toru, Chin, Kazuo, Hirai, Toyohiro, and Date, Hiroshi

Published
2018
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18. Fatal case of methotrexate‐associated primary cutaneous extranodal NK/T‐cell lymphoma of gamma delta phenotype

Author

Sugimoto, Akihiko, primary, Fujimoto, Masakazu, additional, Fujii, Hirotake, additional, Takeuchi, Yasuhide, additional, Hirata, Masahiro, additional, Usui, Shunya, additional, Nakamizo, Satoshi, additional, Ikezoe, Kohei, additional, Ikeo, Satoshi, additional, Yamada, Yosuke, additional, Minamiguchi, Sachiko, additional, Morinobu, Akio, additional, and Haga, Hironori, additional

Published
2022
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24. Small Airway Reduction and Fibrosis Is an Early Pathologic Feature of Idiopathic Pulmonary Fibrosis

Author

Ikezoe, Kohei, primary, Hackett, Tillie-Louise, additional, Peterson, Samuel, additional, Prins, Dante, additional, Hague, Cameron J., additional, Murphy, Darra, additional, LeDoux, Stacey, additional, Chu, Fanny, additional, Xu, Feng, additional, Cooper, Joel D., additional, Tanabe, Naoya, additional, Ryerson, Christopher J., additional, Paré, Peter D., additional, Coxson, Harvey O., additional, Colby, Thomas V., additional, Hogg, James C., additional, and Vasilescu, Dragoş M., additional

Published
2021
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26. Pathological Comparisons of Paraseptal and Centrilobular Emphysema in Chronic Obstructive Pulmonary Disease

Author

Tanabe, Naoya, primary, Vasilescu, Dragoş M., additional, Hague, Cameron J., additional, Ikezoe, Kohei, additional, Murphy, Darra T., additional, Kirby, Miranda, additional, Stevenson, Christopher S., additional, Verleden, Stijn E., additional, Vanaudenaerde, Bart M., additional, Gayan-Ramirez, Ghislaine, additional, Janssens, Wim, additional, Coxson, Harvey O., additional, Paré, Peter D., additional, and Hogg, James C., additional

Published
2020
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27. Pathology of Idiopathic Pulmonary Fibrosis Assessed by a Combination of Microcomputed Tomography, Histology, and Immunohistochemistry

Author

30805817, 90771733, Tanabe, Naoya, McDonough, John E., Vasilescu, Dragoş M., Ikezoe, Kohei, Verleden, Stijn E., Xu, Feng, Wuyts, Wim A., Vanaudenaerde, Bart M., Colby, Thomas V., Hogg, James C., 30805817, 90771733, Tanabe, Naoya, McDonough, John E., Vasilescu, Dragoş M., Ikezoe, Kohei, Verleden, Stijn E., Xu, Feng, Wuyts, Wim A., Vanaudenaerde, Bart M., Colby, Thomas V., and Hogg, James C.

Abstract

Idiopathic pulmonary fibrosis (IPF) is a fibrotic disease showing the histology of usual interstitial pneumonia (UIP). While the pathologist's visual inspection is central in histological assessments, three-dimensional microCT assessment may complement pathologist's scoring. This study examined associations between the histopathological features of UIP/IPF in explanted lungs and quantitative microCT measurements including alveolar surface density, total lung volume taken up by tissue (tissue%), and terminal bronchiolar number. Sixty frozen samples from 10 air-inflated explanted lungs with severe IPF and 36 samples from 6 donor control lungs were scanned with microCT and processed for histology. An experienced pathologist scored 3 major UIP criteria (patchy fibrosis, honeycomb, and fibroblastic foci), 5 additional pathological changes such as emphysema, and immunohistochemical staining for CD68, CD4, CD8, and CD79a positive cells, graded on a 0-3+ scale. The alveolar surface density and terminal bronchiolar number decreased and the tissue% increased in IPF compared to controls. In lungs with IPF, lower alveolar surface density and higher tissue% were correlated with greater scores of patchy fibrosis, fibroblastic foci, honeycomb, CD79a-positive cells, and lymphoid follicles. A decreased number of terminal bronchioles was correlated with honeycomb score, but not with the other scores. The three-dimensional microCT measurements reflect the pathological UIP/IPF criteria and further suggest that the reduction in the terminal bronchioles may be associated with honeycomb cyst formation.

Published
2020

28. The transition from normal lung anatomy to Fibrosis in IPF

Author

xu, feng, primary, Tanabe, Naoya, additional, Macdonough, John, additional, Vasilescu, Dragos, additional, Ikezoe, Kohei, additional, Kinose, Diasuke, additional, Ng, Kevin, additional, Verleden, Stijn, additional, Vanaudenaerde, Bart, additional, Verschakelen, Johny, additional, Cooper, Joel, additional, Lenburg, Marc, additional, Spira, Avrum, additional, Ng, Raymond, additional, and Hogg, Jim, additional

Published
2019
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29. Nutrition-related factors associated with waiting list mortality in patients with interstitial lung disease: a retrospective cohort study

Author

Oshima, Ayako, primary, Nishimura, Akiko, additional, Chen-Yoshikawa, Toyofumi, additional, Harashima, Shin-Ichi, additional, Komatsu, Teruya, additional, Handa, Tomohiro, additional, Aoyama, Akihiro, additional, Takahashi, Koji, additional, Ikeda, Masaki, additional, Oshima, Yohei, additional, Ikezoe, Kohei, additional, Sato, Susumu, additional, Isomi, Maki, additional, Shide, Kenichiro, additional, Date, Hiroshi, additional, and Inagaki, Nobuya, additional

Published
2019
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30. Serum matrix metalloproteinase levels in polymyositis/dermatomyositis patients with interstitial lung disease

Author

Nakatsuka, Yoshinari, primary, Handa, Tomohiro, additional, Nakashima, Ran, additional, Tanizawa, Kiminobu, additional, Kubo, Takeshi, additional, Murase, Yuko, additional, Sokai, Akihiko, additional, Ikezoe, Kohei, additional, Hosono, Yuji, additional, Watanabe, Kizuku, additional, Tokuda, Shinsaku, additional, Uno, Kazuko, additional, Yoshizawa, Akihiko, additional, Tsuruyama, Tatsuaki, additional, Uozumi, Ryuji, additional, Nagai, Sonoko, additional, Hatta, Kazuhiro, additional, Taguchi, Yoshio, additional, Mishima, Michiaki, additional, Chin, Kazuo, additional, Mimori, Tsuneyo, additional, and Hirai, Toyohiro, additional

Published
2019
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31. Additional file 1: of Clinical significance of radiological pleuroparenchymal fibroelastosis pattern in interstitial lung disease patients registered for lung transplantation: a retrospective cohort study

Author

Kiminobu Tanizawa, Handa, Tomohiro, Kubo, Takeshi, Toyofumi Chen-Yoshikawa, Aoyama, Akihiro, Motoyama, Hideki, Hijiya, Kyoko, Yoshizawa, Akihiko, Oshima, Yohei, Ikezoe, Kohei, Tokuda, Shinsaku, Nakatsuka, Yoshinari, Murase, Yuko, Nagai, Sonoko, Muro, Shigeo, Oga, Toru, Chin, Kazuo, Toyohiro Hirai, and Date, Hiroshi

Abstract

Table S1. Sixteen radiological PPFE cases with a histopathological diagnosis. (DOCX 16 kb)

Published
2018
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32. Pathological Comparisons of Paraseptal and Centrilobular Emphysema in Chronic Obstructive Pulmonary Disease.

Author

Naoya Tanabe, Vasilescu, Dragoş M., Hague, Cameron J., Ikezoe, Kohei, Murphy, Darra T., Kirby, Miranda, Stevenson, Christopher S., Verleden, Stijn E., Vanaudenaerde, Bart M., Gayan-Ramirez, Ghislaine, Janssens, Wim, Coxson, Harvey O., Paré, Peter D., Hogg, James C., and Tanabe, Naoya

Subjects
OBSTRUCTIVE lung diseases, PULMONARY emphysema, MULTIDETECTOR computed tomography, LUNG transplantation, BRONCHIOLES, RESEARCH, CROSS-sectional method, RESEARCH methodology, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, RESEARCH funding, DISEASE complications
Abstract

Rationale: Although centrilobular emphysema (CLE) and paraseptal emphysema (PSE) are commonly identified on multidetector computed tomography (MDCT), little is known about the pathology associated with PSE compared with that of CLE.Objectives: To assess the pathological differences between PSE and CLE in chronic obstructive pulmonary disease (COPD).Methods: Air-inflated frozen lung specimens (n = 6) obtained from patients with severe COPD treated by lung transplantation were scanned with MDCT. Frozen tissue cores were taken from central (n = 8) and peripheral (n = 8) regions of each lung, scanned with micro-computed tomography (microCT), and processed for histology. The core locations were registered to the MDCT, and a percentage of PSE or CLE was assigned by radiologists to each of the regions. MicroCT scans were used to measure number and structural change of terminal bronchioles. Furthermore, microCT-based volume fractions of CLE and PSE allowed classifying cores into mild emphysema, CLE-dominant, and PSE-dominant.Measurements and Main Results: The percentages of PSE measured on MDCT and microCT were positively associated (P = 0.015). The number of terminal bronchioles per milliliter of lung and cross-sectional lumen area were significantly lower and wall area percentage was significantly higher in CLE-dominant regions compared with mild emphysema and PSE-dominant regions (all P < 0.05), whereas no difference was found between PSE-dominant and mild emphysema samples (all P > 0.5). Immunohistochemistry showed significantly higher infiltration of neutrophils (P = 0.002), but not of macrophages, CD4, CD8, or B cells, in PSE compared with CLE regions.Conclusions: The terminal bronchioles are relatively preserved, whereas neutrophilic inflammation is increased in PSE-dominant regions compared with CLE-dominant regions in patients with COPD. [ABSTRACT FROM AUTHOR]

Published
2020
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33. The Clinical Significance of Body Weight Loss in Idiopathic Pulmonary Fibrosis Patients

Author

Nakatsuka, Yoshinari, primary, Handa, Tomohiro, additional, Kokosi, Maria, additional, Tanizawa, Kiminobu, additional, Puglisi, Silvia, additional, Jacob, Joseph, additional, Sokai, Akihiko, additional, Ikezoe, Kohei, additional, Kanatani, Kumiko T., additional, Kubo, Takeshi, additional, Tomioka, Hiromi, additional, Taguchi, Yoshio, additional, Nagai, Sonoko, additional, Chin, Kazuo, additional, Mishima, Michiaki, additional, Wells, Athol U., additional, and Hirai, Toyohiro, additional

Published
2018
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34. Prognostic factors and outcomes in Japanese lung transplant candidates with interstitial lung disease

Author

Ikezoe, Kohei, primary, Handa, Tomohiro, additional, Tanizawa, Kiminobu, additional, Chen-Yoshikawa, Toyofumi F., additional, Kubo, Takeshi, additional, Aoyama, Akihiro, additional, Motoyama, Hideki, additional, Hijiya, Kyoko, additional, Tokuda, Shinsaku, additional, Nakatsuka, Yoshinari, additional, Yamamoto, Yuko, additional, Oshima, Ayako, additional, Harashima, Shin-ichi, additional, Nagai, Sonoko, additional, Hirai, Toyohiro, additional, Date, Hiroshi, additional, and Chin, Kazuo, additional

Published
2017
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35. Importance of serial changes in biomarkers in idiopathic pulmonary fibrosis

Author

Sokai, Akihiko, primary, Tanizawa, Kiminobu, additional, Handa, Tomohiro, additional, Kanatani, Kumiko, additional, Kubo, Takeshi, additional, Ikezoe, Kohei, additional, Nakatsuka, Yoshinari, additional, Tokuda, Shinsaku, additional, Oga, Toru, additional, Hirai, Toyohiro, additional, Nagai, Sonoko, additional, Chin, Kazuo, additional, and Mishima, Michiaki, additional

Published
2017
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36. Asymmetry in acute exacerbation of idiopathic pulmonary fibrosis

Author

Sokai, Akihiko, primary, Tanizawa, Kiminobu, additional, Handa, Tomohiro, additional, Kubo, Takeshi, additional, Hashimoto, Seishu, additional, Ikezoe, Kohei, additional, Nakatsuka, Yoshinari, additional, Aihara, Kensaku, additional, Taguchi, Yoshio, additional, Muro, Shigeo, additional, Oga, Toru, additional, Nagai, Sonoko, additional, Izumi, Takateru, additional, Hirai, Toyohiro, additional, Chin, Kazuo, additional, and Mishima, Michiaki, additional

Published
2017
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37. Comprehensive evaluation of airway involvement in pulmonary sarcoidosis

Author

20639140, 10432395, 50601324, 20464216, 90771733, 60359809, 20359805, Tanizawa, Kiminobu, Handa, Tomohiro, Nagai, Sonoko, Niimi, Akio, Oguma, Tsuyoshi, Kubo, Takeshi, Ito, Yutaka, Aihara, Kensaku, Ikezoe, Kohei, Matsumoto, Hisako, Hirai, Toyohiro, Chin, Kazuo, Mishima, Michiaki, 20639140, 10432395, 50601324, 20464216, 90771733, 60359809, 20359805, Tanizawa, Kiminobu, Handa, Tomohiro, Nagai, Sonoko, Niimi, Akio, Oguma, Tsuyoshi, Kubo, Takeshi, Ito, Yutaka, Aihara, Kensaku, Ikezoe, Kohei, Matsumoto, Hisako, Hirai, Toyohiro, Chin, Kazuo, and Mishima, Michiaki

Abstract

IOS can predict airway hyperresponsiveness and long-term outcome in patients with pulmonary sarcoidosis.

Published
2017

38. Additional file 1: Table S1. of Matrix metalloproteinase-10: a novel biomarker for idiopathic pulmonary fibrosis

Author

Sokai, Akihiko, Handa, Tomohiro, Kiminobu Tanizawa, Oga, Toru, Uno, Kazuko, Tatsuaki Tsuruyama, Kubo, Takeshi, Ikezoe, Kohei, Nakatsuka, Yoshinari, Tanimura, Kazuya, Muro, Shigeo, Toyohiro Hirai, Nagai, Sonoko, Chin, Kazuo, and Mishima, Michiaki

Subjects
respiratory system, humanities, respiratory tract diseases
Abstract

Treatment for IPF at baseline. Table S2. Univariate analyses utilized to predict clinical deterioration and mortality when 13 treated patients with IPF were excluded. (DOCX 24 kb)

Published
2015
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39. Chronic Kidney Disease Predicts Survival in Patients with Idiopathic Pulmonary Fibrosis

Author

Ikezoe, Kohei, primary, Handa, Tomohiro, additional, Tanizawa, Kiminobu, additional, Yokoi, Hideki, additional, Kubo, Takeshi, additional, Aihara, Kensaku, additional, Sokai, Akihiko, additional, Nakatsuka, Yoshinari, additional, Hashimoto, Seishu, additional, Uemasu, Kiyoshi, additional, Sato, Susumu, additional, Muro, Shigeo, additional, Nagai, Sonoko, additional, Yanagita, Motoko, additional, Chin, Kazuo, additional, Hirai, Toyohiro, additional, Taguchi, Yoshio, additional, and Mishima, Michiaki, additional

Published
2017
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40. Comprehensive evaluation of airway involvement in pulmonary sarcoidosis

Author

Tanizawa, Kiminobu, primary, Handa, Tomohiro, additional, Nagai, Sonoko, additional, Niimi, Akio, additional, Oguma, Tsuyoshi, additional, Kubo, Takeshi, additional, Ito, Yutaka, additional, Aihara, Kensaku, additional, Ikezoe, Kohei, additional, Matsumoto, Hisako, additional, Hirai, Toyohiro, additional, Chin, Kazuo, additional, and Mishima, Michiaki, additional

Published
2017
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41. Aquaporin-3 potentiates allergic airway inflammation in ovalbumin-induced murine asthma

Author

90771733, 00303842, 20639140, 10432395, Ikezoe, Kohei, Oga, Toru, Honda, Tetsuya, Hara-Chikuma, Mariko, Ma, Xiaojun, Tsuruyama, Tatsuaki, Uno, Kazuko, Fuchikami, Jun Ichi, Tanizawa, Kiminobu, Handa, Tomohiro, Taguchi, Yoshio, Verkman, Alan S., Narumiya, Shuh, Mishima, Michiaki, Chin, Kazuo, 90771733, 00303842, 20639140, 10432395, Ikezoe, Kohei, Oga, Toru, Honda, Tetsuya, Hara-Chikuma, Mariko, Ma, Xiaojun, Tsuruyama, Tatsuaki, Uno, Kazuko, Fuchikami, Jun Ichi, Tanizawa, Kiminobu, Handa, Tomohiro, Taguchi, Yoshio, Verkman, Alan S., Narumiya, Shuh, Mishima, Michiaki, and Chin, Kazuo

Abstract

Oxidative stress plays a pivotal role in the pathogenesis of asthma. Aquaporin-3 (AQP3) is a small transmembrane water/glycerol channel that may facilitate the membrane uptake of hydrogen peroxide (H[2]O[2]). Here we report that AQP3 potentiates ovalbumin (OVA)-induced murine asthma by mediating both chemokine production from alveolar macrophages and T cell trafficking. AQP3 deficient (AQP3[-/-]) mice exhibited significantly reduced airway inflammation compared to wild-type mice. Adoptive transfer experiments showed reduced airway eosinophilic inflammation in mice receiving OVA-sensitized splenocytes from AQP3[-/-] mice compared with wild-type mice after OVA challenge, consistently with fewer CD4[+]T cells from AQP3[-/-] mice migrating to the lung than from wild-type mice. Additionally, in vivo and vitro experiments indicated that AQP3 induced the production of some chemokines such as CCL24 and CCL22 through regulating the amount of cellular H[2]O[2] in M2 polarized alveolar macrophages. These results imply a critical role of AQP3 in asthma, and AQP3 may be a novel therapeutic target.

Published
2016

42. Aquaporin-3 potentiates murine asthma through mediating T-cell trafficking and chemokine production

Author

Ikezoe, Kohei, primary, Oga, Toru, additional, Honda, Tetsuya, additional, Hara-Chikuma, Mariko, additional, Ma, Xiaojun, additional, Tsuruyama, Tatsuaki, additional, Uno, Kazuko, additional, Fuchikami, Jun-ichi, additional, Tanizawa, Kiminobu, additional, Handa, Tomohiro, additional, Taguchi, Yoshio, additional, Verkman, Alan, additional, Narumiya, Shuh, additional, Mishima, Michiaki, additional, and Chin, Kazuo, additional

Published
2016
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44. Matrix metalloproteinase-10: A novel biomarker for idiopathic pulmonary fibrosis

Author

10432395, 20639140, 00303842, 20464216, 90771733, 60344454, 20359805, Sokai, Akihiko, Handa, Tomohiro, Tanizawa, Kiminobu, Oga, Toru, Uno, Kazuko, Tsuruyama, Tatsuaki, Kubo, Takeshi, Ikezoe, Kohei, Nakatsuka, Yoshinari, Tanimura, Kazuya, Muro, Shigeo, Hirai, Toyohiro, Nagai, Sonoko, Chin, Kazuo, Mishima, Michiaki, 10432395, 20639140, 00303842, 20464216, 90771733, 60344454, 20359805, Sokai, Akihiko, Handa, Tomohiro, Tanizawa, Kiminobu, Oga, Toru, Uno, Kazuko, Tsuruyama, Tatsuaki, Kubo, Takeshi, Ikezoe, Kohei, Nakatsuka, Yoshinari, Tanimura, Kazuya, Muro, Shigeo, Hirai, Toyohiro, Nagai, Sonoko, Chin, Kazuo, and Mishima, Michiaki

Published
2015

45. Clinical impact of high-attenuation and cystic areas on computed tomography in fibrotic idiopathic interstitial pneumonias

Author

20639140, 10432395, 20359805, 20464216, 50601324, 40447975, 60828945, 90771733, Tanizawa, Kiminobu, Handa, Tomohiro, Nagai, Sonoko, Hirai, Toyohiro, Kubo, Takeshi, Oguma, Tsuyoshi, Ito, Isao, Ito, Yutaka, Watanabe, Kizuku, Aihara, Kensaku, Ikezoe, Kohei, Oga, Toru, Chin, Kazuo, Izumi, Takateru, Mishima, Michiaki, 20639140, 10432395, 20359805, 20464216, 50601324, 40447975, 60828945, 90771733, Tanizawa, Kiminobu, Handa, Tomohiro, Nagai, Sonoko, Hirai, Toyohiro, Kubo, Takeshi, Oguma, Tsuyoshi, Ito, Isao, Ito, Yutaka, Watanabe, Kizuku, Aihara, Kensaku, Ikezoe, Kohei, Oga, Toru, Chin, Kazuo, Izumi, Takateru, and Mishima, Michiaki

Abstract

Background: Quantitative computed tomography (CT) analysis has been proposed as a means of objectively assessing fibrotic interstitial pneumonia (IP) including idiopathic pulmonary fibrosis (IPF). We investigated whether percentages of high-attenuation areas (HAA%) and cystic areas (CA%) quantified from CT images were useful as indices of fibrotic IP. Methods: CT images of 74 patients with fibrotic idiopathic interstitial pneumonias (IPF, 36; non-specific interstitial pneumonia, 9; unclassifiable idiopathic interstitial pneumonia, 29) were analyzed via in-house computer software, which automatically calculated HAA%, CA%, mean lung density (MLD), standard deviation of lung density (SD-LD), kurtosis, and skewness from CT attenuation histograms. These indices were compared in each instance with physiologic measures, visual fibrosis score, clinical diagnosis, radiologic CT pattern, and prognosis. Results: HAA% correlated significantly with physiologic measures and visual fibrosis score to a moderate extent (%forced vital capacity, rs = -0.59; % carbon monoxide diffusion capacity, rs = -0.43; fibrosis score, rs = 0.23). Densitometric parameters (MLD, SD-LD, kurtosis, and skewness) correlated significantly with physiologic measures and fibrosis score (|rs| = 0.28-0.59). CA% showed no association with pulmonary functions but differed significantly between IPF and other interstitial pneumonias (IPs) (1.50 ± 2.41 % vs. 0.41 ± 0.80 %; P < 0.01) and between the definite usual interstitial pneumonia (UIP) pattern and other patterns (1.48 ± 2.38 % vs. 0.55 ± 1.19 %; P < 0.01). On univariate analysis, HAA%, MLD, SD-LD, kurtosis, skewness, fibrosis score, and definite UIP pattern all correlated with survival, with kurtosis alone identified as a significant predictor of mortality on multivariate analysis (hazard ratio = 0.67; 95 % CI, 0.44-0.96; P = 0.03). Conclusion: CA% and HAA% are novel quantitative CT indices with differing propertie

Published
2015

46. Matrix metalloproteinase-10: a novel biomarker for idiopathic pulmonary fibrosis

Author

Sokai, Akihiko, primary, Handa, Tomohiro, additional, Tanizawa, Kiminobu, additional, Oga, Toru, additional, Uno, Kazuko, additional, Tsuruyama, Tatsuaki, additional, Kubo, Takeshi, additional, Ikezoe, Kohei, additional, Nakatsuka, Yoshinari, additional, Tanimura, Kazuya, additional, Muro, Shigeo, additional, Hirai, Toyohiro, additional, Nagai, Sonoko, additional, Chin, Kazuo, additional, and Mishima, Michiaki, additional

Published
2015
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47. Clinical impact of high-attenuation and cystic areas on computed tomography in fibrotic idiopathic interstitial pneumonias

Author

Tanizawa, Kiminobu, primary, Handa, Tomohiro, additional, Nagai, Sonoko, additional, Hirai, Toyohiro, additional, Kubo, Takeshi, additional, Oguma, Tsuyoshi, additional, Ito, Isao, additional, Ito, Yutaka, additional, Watanabe, Kizuku, additional, Aihara, Kensaku, additional, Ikezoe, Kohei, additional, Oga, Toru, additional, Chin, Kazuo, additional, Izumi, Takateru, additional, and Mishima, Michiaki, additional

Published
2015
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48. This title is unavailable for guests, please login to see more information.

Author

10432395, 90378670, 60828945, 20639140, 90771733, 90197640, Aihara, Kensaku, Handa, Tomohiro, Oga, Toru, Watanabe, Kizuku, Tanizawa, Kiminobu, Ikezoe, Kohei, Taguchi, Yoshio, Sato, Hiroe, Chin, Kazuo, Nagai, Sonoko, Narumiya, Shuh, Wells, Athol U, Mishima, Michiaki, 10432395, 90378670, 60828945, 20639140, 90771733, 90197640, Aihara, Kensaku, Handa, Tomohiro, Oga, Toru, Watanabe, Kizuku, Tanizawa, Kiminobu, Ikezoe, Kohei, Taguchi, Yoshio, Sato, Hiroe, Chin, Kazuo, Nagai, Sonoko, Narumiya, Shuh, Wells, Athol U, and Mishima, Michiaki

Published
2013

49. Impaired endothelium-dependent vasodilator response in patients with pulmonary fibrosis.

Author

10432395, 20639140, 90771733, 60828945, 90378670, 30467485, 90197640, Aihara, Kensaku, Handa, Tomohiro, Nagai, Sonoko, Tanizawa, Kiminobu, Ikezoe, Kohei, Watanabe, Kizuku, Chihara, Yuichi, Harada, Yuka, Yoshimura, Chikara, Oga, Toru, Ozasa, Neiko, Uno, Kazuko, Chin, Kazuo, Mishima, Michiaki, 10432395, 20639140, 90771733, 60828945, 90378670, 30467485, 90197640, Aihara, Kensaku, Handa, Tomohiro, Nagai, Sonoko, Tanizawa, Kiminobu, Ikezoe, Kohei, Watanabe, Kizuku, Chihara, Yuichi, Harada, Yuka, Yoshimura, Chikara, Oga, Toru, Ozasa, Neiko, Uno, Kazuko, Chin, Kazuo, and Mishima, Michiaki

Abstract

[Background] Recent epidemiological evidence indicates an association between cardiovascular diseases and pulmonary fibrosis. The vascular endothelium acts to maintain vascular homeostasis through multiple mechanisms and impaired endothelial function can contribute to the development, progression and clinical expression of atherosclerosis. [Methods] We consecutively recruited 39 newly-diagnosed chronic interstitial pneumonitis/fibrosis patients without any specific etiology. We assessed endothelium-dependent vasodilator response of patients using digital pulse amplitude tonometry and compared the reactive hyperemia index (RHI) with age-, sex- and body mass index-matched control subjects (n = 30). We further investigated the relationships between RHI and clinical characteristics, laboratory cardiovascular risk factors, disease-related factors and circulating levels of inflammatory biomarkers. [Results] RHI was significantly lower in patients with chronic interstitial pneumonitis/fibrosis than in control subjects (p = 0.02). While circulating levels of total cholesterol, triglycerides, HbA1c and fasting glucose did not differ significantly between groups, patients with chronic interstitial pneumonitis/fibrosis had significantly lower high density lipoprotein levels and higher low density lipoprotein levels as compared with control subjects. Regarding disease-related factors, RHI was significantly associated with the diffusing capacity for carbon monoxide, alveolar-arterial oxygen pressure difference, 6-min walk distance and end-exercise oxygen saturation. Additionally, circulating levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 were inversely correlated with RHI. [Conclusions] We confirmed a possible link between pulmonary fibrosis and cardiovascular disease by demonstrating an impairment of endothelium-dependent vasodilator response, which was significantly associated with the severity of pulmonary fibrosis and circulating levels of

Published
2013

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