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2. Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors

Author

Kuehn, Julia C., Metzger, Patrick, Neidert, Nicolas, Matysiak, Uta, Gräßel, Linda, Philipp, Ulrike, Bleul, Sabine, Pauli, Thomas, Falkenstein, Julia, Bertemes, Henriette, Cysar, Stepan, Hess, Maria Elena, Frey, Anna Verena, Duque-Afonso, Jesús, Schorb, Elisabeth, Machein, Marcia, Beck, Jürgen, Schnell, Oliver, von Bubnoff, Nikolas, Illert, Anna L., Peters, Christoph, Brummer, Tilman, Prinz, Marco, Miething, Cornelius, Becker, Heiko, Lassmann, Silke, Werner, Martin, Börries, Melanie, Duyster, Justus, Heiland, Dieter H., Sankowski, Roman, and Scherer, Florian

Published
2024
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3. Profile of the multicenter cohort of the German Cancer Consortium’s Clinical Communication Platform

Author

Maier, Daniel, Vehreschild, Jörg Janne, Uhl, Barbara, Meyer, Sandra, Berger-Thürmel, Karin, Boerries, Melanie, Braren, Rickmer, Grünwald, Viktor, Hadaschik, Boris, Palm, Stefan, Singer, Susanne, Stuschke, Martin, Juárez, David, Delpy, Pierre, Lambarki, Mohamed, Hummel, Michael, Engels, Cäcilia, Andreas, Stefanie, Gökbuget, Nicola, Ihrig, Kristina, Burock, Susen, Keune, Dietmar, Eggert, Angelika, Keilholz, Ulrich, Schulz, Hagen, Büttner, Daniel, Löck, Steffen, Krause, Mechthild, Esins, Mirko, Ressing, Frank, Schuler, Martin, Brandts, Christian, Brucker, Daniel P., Husmann, Gabriele, Oellerich, Thomas, Metzger, Patrick, Voigt, Frederik, Illert, Anna L., Theobald, Matthias, Kindler, Thomas, Sudhof, Ursula, Reckmann, Achim, Schwinghammer, Felix, Nasseh, Daniel, Weichert, Wilko, von Bergwelt-Baildon, Michael, Bitzer, Michael, Malek, Nisar, Öner, Öznur, Schulze-Osthoff, Klaus, Bartels, Stefan, Haier, Jörg, Ammann, Raimund, Schmidt, Anja Franziska, Guenther, Bernd, Janning, Melanie, Kasper, Bernd, Loges, Sonja, Stilgenbauer, Stephan, Kuhn, Peter, Tausch, Eugen, Runow, Silvana, Kerscher, Alexander, Neumann, Michael, Breu, Martin, Lablans, Martin, and Serve, Hubert

Published
2023
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5. Gene editing of hematopoietic stem cells restores T-cell response in familial hemophagocytic lymphohistiocytosis

Author

Dettmer-Monaco, Viviane, Weißert, Kristoffer, Ammann, Sandra, Monaco, Gianni, Lei, Lei, Gräßel, Linda, Rhiel, Manuel, Rositzka, Julia, Kaufmann, Masako M., Geiger, Kerstin, Andrieux, Geoffroy, Lao, Jessica, Thoulass, Gudrun, Schell, Christoph, Boerries, Melanie, Illert, Anna L., Cornu, Tatjana I., Ehl, Stephan, Aichele, Peter, and Cathomen, Toni

Published
2024
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6. Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation

Author

Ho, Jenny N.H.G., Schmidt, Dominik, Lowinus, Theresa, Ryoo, Jeongmin, Dopfer, Elaine-Pashupati, Gonzalo Núñez, Nicolás, Costa-Pereira, Sara, Toffalori, Cristina, Punta, Marco, Fetsch, Viktor, Wertheimer, Tobias, Rittmann, Marie-Claire, Braun, Lukas M., Follo, Marie, Briere, Christelle, Vinnakota, Janaki Manoja, Langenbach, Marlene, Koppers, Felicitas, Shoumariyeh, Khalid, Engel, Helena, Rückert, Tamina, Märklin, Melanie, Holzmayer, Samuel, Illert, Anna L., Magon, Federica, Andrieux, Geoffroy, Duquesne, Sandra, Pfeifer, Dietmar, Staniek, Julian, Rizzi, Marta, Miething, Cornelius, Köhler, Natalie, Duyster, Justus, Menssen, Hans D., Boerries, Melanie, Buescher, Joerg M., Cabezas-Wallscheid, Nina, Blazar, Bruce R., Apostolova, Petya, Vago, Luca, Pearce, Erika L., Becher, Burkhard, and Zeiser, Robert

Published
2022
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9. Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity

Author

Möhrmann, Lino, Werner, Maximilian, Oleś, Małgorzata, Mock, Andreas, Uhrig, Sebastian, Jahn, Arne, Kreutzfeldt, Simon, Fröhlich, Martina, Hutter, Barbara, Paramasivam, Nagarajan, Richter, Daniela, Beck, Katja, Winter, Ulrike, Pfütze, Katrin, Heilig, Christoph E., Teleanu, Veronica, Lipka, Daniel B., Zapatka, Marc, Hanf, Dorothea, List, Catrin, Allgäuer, Michael, Penzel, Roland, Rüter, Gina, Jelas, Ivan, Hamacher, Rainer, Falkenhorst, Johanna, Wagner, Sebastian, Brandts, Christian H., Boerries, Melanie, Illert, Anna L., Metzeler, Klaus H., Westphalen, C. Benedikt, Desuki, Alexander, Kindler, Thomas, Folprecht, Gunnar, Weichert, Wilko, Brors, Benedikt, Stenzinger, Albrecht, Schröck, Evelin, Hübschmann, Daniel, Horak, Peter, Heining, Christoph, Fröhling, Stefan, and Glimm, Hanno

Published
2022
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10. Obinutuzumab (GA-101), ibrutinib, and venetoclax (GIVe) frontline treatment for high-risk chronic lymphocytic leukemia

Author

Huber, Henriette, Edenhofer, Simone, von Tresckow, Julia, Robrecht, Sandra, Zhang, Can, Tausch, Eugen, Schneider, Christof, Bloehdorn, Johannes, Fürstenau, Moritz, Dreger, Peter, Ritgen, Matthias, Illmer, Thomas, Illert, Anna L., Dürig, Jan, Böttcher, Sebastian, Niemann, Carsten U., Kneba, Michael, Fink, Anna-Maria, Fischer, Kirsten, Döhner, Hartmut, Hallek, Michael, Eichhorst, Barbara, and Stilgenbauer, Stephan

Published
2022
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11. Primary results of patients with genitourinary malignancies presented at a Molecular Tumor Board

Author

Michaelis, Jakob, primary, Himmelsbach, Ruth, additional, Metzger, Patrick, additional, Lassmann, Silke, additional, Börries, Melanie, additional, Werner, Martin, additional, Miething, Cornelius, additional, Höfflin, Rouven, additional, Illert, Anna L., additional, Duyster, Justus, additional, Becker, Heiko, additional, Sigle, August, additional, Gratzke, Christian, additional, and Grabbert, Markus, additional

Published
2024
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14. CXCR4-targeted Theranostics in Hematooncology: Opportunities and Challenges

Author

Werner, Rudolf, additional, Haug, Alexander, additional, Buske, Christian, additional, Heidegger, Simon, additional, Illert, Anna L., additional, Bassermann, Florian, additional, Herhaus, Peter, additional, Buck, Andreas, additional, Duell, Johannes, additional, Topp, Max S, additional, Kraus, Sabrina, additional, Einsele, Hermann, additional, Lapa, Constantin, additional, Raderer, Markus, additional, Lenz, Georg, additional, Habringer, Stefan, additional, von Tresckow, Bastian, additional, and Keller, Ulrich, additional

Published
2024
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15. Existence of reprogrammed lymphoma stem cells in a murine ALCL-like model

Author

Kreutmair, Stefanie, Klingeberg, Cathrin, Poggio, Teresa, Andrieux, Geoffroy, Keller, Alexander, Miething, Cornelius, Follo, Marie, Pfeifer, Dietmar, Shoumariyeh, Khalid, Lengerke, Claudia, Gonzalez-Menendez, Irene, Fend, Falko, Zeiser, Robert, Turner, Suzanne D., Quintanilla-Martinez, Leticia, Boerries, Melanie, Duyster, Justus, and Illert, Anna L.

Published
2020
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17. Community-driven development of a modified progression-free survival ratio for precision oncology

Author

Mock, Andreas, Heilig, Christoph E, Kreutzfeldt, Simon, Huebschmann, Daniel, Heining, Christoph, Schröck, Evelin, Brors, Benedikt, Stenzinger, Albrecht, Jäger, Dirk, Schlenk, Richard, Glimm, Hanno, Fröhling, Stefan, Horak, Peter, Apostolidis, Leonidas, Augustin, Marinela, Aust, Daniela, Bhatti, Irfan Ahmed, Bloehdorn, Johannes, Brendel, Cornelia, Britschgi, Christian, Braess, Jan, Burdach, Stefan, Busch, Elena, Casuscelli, Jozefina, Desuki, Alexander, Deutsch, Thomas, Dietrich, Mareike, Ehmer, Ursula, Ettrich, Thomas J, Falkenhorst, Johanna, Fehm, Tanja, Flörcken, Anne, Forschner, Andrea, Fuxius, Stefan, Gonzales-Carmona, Maria, Griesinger, Frank, Grill, Sabine, Gröschel, Stefan, Haag, Georg Martin, Haag, Ulrich, Halama, Niels, Hebart, Holger, Heidger, Nina, Hermes, Barbara, Hess, Georg, Hettmer, Simone, Hoechstetter, Manuela, Hoffmann, Martin, Hüttner, Felix J, Illert, Anna L, Jenzer, Maximilian, Kasper, Bernd, Kasper-Virchow, Stefan, Kindler, Thomas, Koscielniak, Ewa, Krönke, Jan, Kühn, Michael, Kunzmann, Volker, Lang, Alois, Leichsenring, Jonas, Livingstone, Elisabeth, Liotta, Lucia, Luley, Kim, Mack, Elisabeth, Martens, Uwe M, Metzeler, Klaus, Middeke, Jan Moritz, Möhrmann, Lino, Jayarama-Naidu, Roopa, Pape, Ulrich-Frank, Perkhofer, Lukas, Pfeufer, Arne, Pixberg, Constantin, Quante, Michael, Rendenbach, Bernhard, Rieke, Damian, Rothermundt, Christian, Sagerer, Andre Norbert, Salzmann, Martin, Saur, Dieter, Schilling, Bastian, Schleicher, Jan, Schlenska-Lange, Anke, Schmidt, Thomas, Schmitz, Sophia, Schölch, Sebastian, Shah, Rajiv, Shoumariyeh, Khalid, Siebenhüner, Alexander, Singh, Martin, Siveke, Jens, Springfeld, Christoph, Starke, Helen, Strobel, Sophia, Teleanu, Veronica, Thon, Niklas, Wagner, Sebastian, Walle, Thomas, Westphalen, Benedikt, Whitlock, Bettina, Winkler, Eva, Wirsik, Naita Maren, Woydack, Lena, Bois, Angelika Zabel-du, and Zschäbitz, Stefanie

Published
2019
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18. MIRACUM-Pipe: An Adaptable Pipeline for Next-Generation Sequencing Analysis, Reporting, and Visualization for Clinical Decision Making

Author

Metzger, Patrick, primary, Hess, Maria Elena, additional, Blaumeiser, Andreas, additional, Pauli, Thomas, additional, Schipperges, Vincent, additional, Mertes, Ralf, additional, Christoph, Jan, additional, Unberath, Philipp, additional, Reimer, Niklas, additional, Scheible, Raphael, additional, Illert, Anna L., additional, Busch, Hauke, additional, Andrieux, Geoffroy, additional, and Boerries, Melanie, additional

Published
2023
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19. Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer

Author

Scherr, Anna-Lena, Mock, Andreas, Gdynia, Georg, Schmitt, Nathalie, Heilig, Christoph E., Korell, Felix, Rhadakrishnan, Praveen, Hoffmeister, Paula, Metzeler, Klaus H., Schulze-Osthoff, Klaus, Illert, Anna L., Boerries, Melanie, Trojan, Jörg, Waidmann, Oliver, Falkenhorst, Johanna, Siveke, Jens, Jost, Philipp J., Bitzer, Michael, Malek, Nisar P., Vecchione, Loredana, Jelas, Ivan, Brors, Benedikt, Glimm, Hanno, Stenzinger, Albrecht, Grekova, Svetlana P., Gehrig, Tobias, Schulze-Bergkamen, Henning, Jäger, Dirk, Schirmacher, Peter, Heikenwalder, Mathias, Goeppert, Benjamin, Schneider, Martin, Fröhling, Stefan, and Köhler, Bruno C.

Published
2020
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20. Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Author

Mathew, Nimitha R, Baumgartner, Francis, Braun, Lukas, O'Sullivan, David, Thomas, Simone, Waterhouse, Miguel, Müller, Tony A, Hanke, Kathrin, Taromi, Sanaz, Apostolova, Petya, Illert, Anna L, Melchinger, Wolfgang, Duquesne, Sandra, Schmitt-Graeff, Annette, Osswald, Lena, Yan, Kai-Li, Weber, Arnim, Tugues, Sonia, Spath, Sabine, Pfeifer, Dietmar, Follo, Marie, Claus, Rainer, Lübbert, Michael, Rummelt, Christoph, Bertz, Hartmut, Wäsch, Ralph, Haag, Johanna, Schmidts, Andrea, Schultheiss, Michael, Bettinger, Dominik, Thimme, Robert, Ullrich, Evelyn, Tanriver, Yakup, Vuong, Giang Lam, Arnold, Renate, Hemmati, Philipp, Wolf, Dominik, Ditschkowski, Markus, Jilg, Cordula, Wilhelm, Konrad, Leiber, Christian, Gerull, Sabine, Halter, Jörg, Lengerke, Claudia, Pabst, Thomas, Schroeder, Thomas, Kobbe, Guido, Rösler, Wolf, Doostkam, Soroush, Meckel, Stephan, Stabla, Kathleen, Metzelder, Stephan K, Halbach, Sebastian, Brummer, Tilman, Hu, Zehan, Dengjel, Joern, Hackanson, Björn, Schmid, Christoph, Holtick, Udo, Scheid, Christof, Spyridonidis, Alexandros, Stölzel, Friedrich, Ordemann, Rainer, Müller, Lutz P, Sicre-de-Fontbrune, Flore, Ihorst, Gabriele, Kuball, Jürgen, Ehlert, Jan E, Feger, Daniel, Wagner, Eva-Maria, Cahn, Jean-Yves, Schnell, Jacqueline, Kuchenbauer, Florian, Bunjes, Donald, Chakraverty, Ronjon, Richardson, Simon, Gill, Saar, Kröger, Nicolaus, Ayuk, Francis, Vago, Luca, Ciceri, Fabio, Müller, Antonia M, Kondo, Takeshi, Teshima, Takanori, Klaeger, Susan, Kuster, Bernhard, Weisdorf, Daniel, van der Velden, Walter, Dörfel, Daniela, Bethge, Wolfgang, Hilgendorf, Inken, Hochhaus, Andreas, Andrieux, Geoffroy, Börries, Melanie, Busch, Hauke, Magenau, John, Reddy, Pavan, Labopin, Myriam, Antin, Joseph H, Henden, Andrea S, Hill, Geoffrey R, Kennedy, Glen A, Bar, Merav, Sarma, Anita, McLornan, Donal, Mufti, Ghulam, Oran, Betul, Rezvani, Katayoun, Shah, Omid, Negrin, Robert S, Nagler, Arnon, Prinz, Marco, Burchert, Andreas, Neubauer, Andreas, Beelen, Dietrich, Mackensen, Andreas, von Bubnoff, Nikolas, Herr, Wolfgang, Becher, Burkhard, Socié, Gerard, Caligiuri, Michael A, Ruggiero, Eliana, Bonini, Chiara, Häcker, Georg, Duyster, Justus, Finke, Jürgen, Pearce, Erika, Blazar, Bruce R, and Zeiser, Robert

Subjects
Interleukin-15 -- Health aspects, Gene mutation -- Health aspects, Sorafenib -- Patient outcomes, Gene expression -- Health aspects, Acute myelocytic leukemia -- Genetic aspects -- Development and progression -- Drug therapy, Biological sciences, Health
Abstract

Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication (ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after allogeneic hematopoietic cell transplantation (allo-HCT) have a 1-year survival rate below 20%. We observed that sorafenib, a multitargeted tyrosine kinase inhibitor, increased IL-15 production by FLT3-ITD[sup.+] leukemia cells. This synergized with the allogeneic CD8[sup.+] T cell response, leading to long-term survival in six mouse models of FLT3-ITD[sup.+] AML. Sorafenib-related IL-15 production caused an increase in CD8[sup.+]CD107a[sup.+]IFN-[gamma][sup.+] T cells with features of longevity (high levels of Bcl-2 and reduced PD-1 levels), which eradicated leukemia in secondary recipients. Mechanistically, sorafenib reduced expression of the transcription factor ATF4, thereby blocking negative regulation of interferon regulatory factor 7 (IRF7) activation, which enhanced IL-15 transcription. Both IRF7 knockdown and ATF4 overexpression in leukemia cells antagonized sorafenib-induced IL-15 production in vitro. Human FLT3-ITD[sup.+] AML cells obtained from sorafenib responders following sorafenib therapy showed increased levels of IL-15, phosphorylated IRF7, and a transcriptionally active IRF7 chromatin state. The mitochondrial spare respiratory capacity and glycolytic capacity of CD8[sup.+] T cells increased upon sorafenib treatment in sorafenib responders but not in nonresponders. Our findings indicate that the synergism of T cells and sorafenib is mediated via reduced ATF4 expression, causing activation of the IRF7-IL-15 axis in leukemia cells and thereby leading to metabolic reprogramming of leukemia-reactive T cells in humans. Therefore, sorafenib treatment has the potential to contribute to an immune-mediated cure of FLT3-ITD-mutant AML relapse, an otherwise fatal complication after allo-HCT., Author(s): Nimitha R Mathew [1, 2]; Francis Baumgartner [1]; Lukas Braun [1]; David O'Sullivan [3]; Simone Thomas [4]; Miguel Waterhouse [1]; Tony A Müller [1]; Kathrin Hanke [1, 2]; Sanaz [...]

Published
2018
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21. Abstract 926: Genomics-based personalized oncology of advanced thymic epithelial tumors

Author

Möhrmann, Lino, primary, Rostock, Lysann, additional, Oleś, Małgorzata, additional, Jahn, Arne, additional, Arlt, Marie, additional, Paramasivam, Nagarajan, additional, Jöhrens, Korinna, additional, Rupp, Luise, additional, Schmitz, Marc, additional, Richter, Daniela, additional, Uhrig, Sebastian, additional, Fröhlich, Martina, additional, Hutter, Barbara, additional, Hüllein, Jennifer, additional, Wolf, Elena E., additional, Hanf, Dorothea, additional, Gieldon, Laura, additional, Kreutzfeldt, Simon, additional, Heilig, Christoph E., additional, Teleanu, Veronica, additional, Lipka, Daniel B., additional, Mock, Andreas, additional, Jelas, Ivan, additional, Rieke, Damian T., additional, Wiesweg, Marcel, additional, Boerries, Melanie, additional, Illert, Anna L., additional, Desuki, Alexander, additional, Kindler, Thomas, additional, Krackhardt, Angela M., additional, Westphalen, C. Benedikt, additional, Grosch, Heidrun, additional, Apostolidis, Leonidas, additional, Stenzinger, Albrecht, additional, Kerle, Irina A., additional, Heining, Christoph, additional, Hübschmann, Daniel, additional, Schröck, Evelin, additional, Fröhling, Stefan, additional, and Glimm, Hanno, additional

Published
2023
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22. Data from Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers

Author

Horak, Peter, primary, Heining, Christoph, primary, Kreutzfeldt, Simon, primary, Hutter, Barbara, primary, Mock, Andreas, primary, Hüllein, Jennifer, primary, Fröhlich, Martina, primary, Uhrig, Sebastian, primary, Jahn, Arne, primary, Rump, Andreas, primary, Gieldon, Laura, primary, Möhrmann, Lino, primary, Hanf, Dorothea, primary, Teleanu, Veronica, primary, Heilig, Christoph E., primary, Lipka, Daniel B., primary, Allgäuer, Michael, primary, Ruhnke, Leo, primary, Laßmann, Andreas, primary, Endris, Volker, primary, Neumann, Olaf, primary, Penzel, Roland, primary, Beck, Katja, primary, Richter, Daniela, primary, Winter, Ulrike, primary, Wolf, Stephan, primary, Pfütze, Katrin, primary, Geörg, Christina, primary, Meißburger, Bettina, primary, Buchhalter, Ivo, primary, Augustin, Marinela, primary, Aulitzky, Walter E., primary, Hohenberger, Peter, primary, Kroiss, Matthias, primary, Schirmacher, Peter, primary, Schlenk, Richard F., primary, Keilholz, Ulrich, primary, Klauschen, Frederick, primary, Folprecht, Gunnar, primary, Bauer, Sebastian, primary, Siveke, Jens Thomas, primary, Brandts, Christian H., primary, Kindler, Thomas, primary, Boerries, Melanie, primary, Illert, Anna L., primary, von Bubnoff, Nikolas, primary, Jost, Philipp J., primary, Spiekermann, Karsten, primary, Bitzer, Michael, primary, Schulze-Osthoff, Klaus, primary, von Kalle, Christof, primary, Klink, Barbara, primary, Brors, Benedikt, primary, Stenzinger, Albrecht, primary, Schröck, Evelin, primary, Hübschmann, Daniel, primary, Weichert, Wilko, primary, Glimm, Hanno, primary, and Fröhling, Stefan, primary

Published
2023
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23. Supplementary Tables S1-S7 from Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers

Author

Horak, Peter, primary, Heining, Christoph, primary, Kreutzfeldt, Simon, primary, Hutter, Barbara, primary, Mock, Andreas, primary, Hüllein, Jennifer, primary, Fröhlich, Martina, primary, Uhrig, Sebastian, primary, Jahn, Arne, primary, Rump, Andreas, primary, Gieldon, Laura, primary, Möhrmann, Lino, primary, Hanf, Dorothea, primary, Teleanu, Veronica, primary, Heilig, Christoph E., primary, Lipka, Daniel B., primary, Allgäuer, Michael, primary, Ruhnke, Leo, primary, Laßmann, Andreas, primary, Endris, Volker, primary, Neumann, Olaf, primary, Penzel, Roland, primary, Beck, Katja, primary, Richter, Daniela, primary, Winter, Ulrike, primary, Wolf, Stephan, primary, Pfütze, Katrin, primary, Geörg, Christina, primary, Meißburger, Bettina, primary, Buchhalter, Ivo, primary, Augustin, Marinela, primary, Aulitzky, Walter E., primary, Hohenberger, Peter, primary, Kroiss, Matthias, primary, Schirmacher, Peter, primary, Schlenk, Richard F., primary, Keilholz, Ulrich, primary, Klauschen, Frederick, primary, Folprecht, Gunnar, primary, Bauer, Sebastian, primary, Siveke, Jens Thomas, primary, Brandts, Christian H., primary, Kindler, Thomas, primary, Boerries, Melanie, primary, Illert, Anna L., primary, von Bubnoff, Nikolas, primary, Jost, Philipp J., primary, Spiekermann, Karsten, primary, Bitzer, Michael, primary, Schulze-Osthoff, Klaus, primary, von Kalle, Christof, primary, Klink, Barbara, primary, Brors, Benedikt, primary, Stenzinger, Albrecht, primary, Schröck, Evelin, primary, Hübschmann, Daniel, primary, Weichert, Wilko, primary, Glimm, Hanno, primary, and Fröhling, Stefan, primary

Published
2023
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24. Supplementary Figures S1-S10 from Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers

Author

Horak, Peter, primary, Heining, Christoph, primary, Kreutzfeldt, Simon, primary, Hutter, Barbara, primary, Mock, Andreas, primary, Hüllein, Jennifer, primary, Fröhlich, Martina, primary, Uhrig, Sebastian, primary, Jahn, Arne, primary, Rump, Andreas, primary, Gieldon, Laura, primary, Möhrmann, Lino, primary, Hanf, Dorothea, primary, Teleanu, Veronica, primary, Heilig, Christoph E., primary, Lipka, Daniel B., primary, Allgäuer, Michael, primary, Ruhnke, Leo, primary, Laßmann, Andreas, primary, Endris, Volker, primary, Neumann, Olaf, primary, Penzel, Roland, primary, Beck, Katja, primary, Richter, Daniela, primary, Winter, Ulrike, primary, Wolf, Stephan, primary, Pfütze, Katrin, primary, Geörg, Christina, primary, Meißburger, Bettina, primary, Buchhalter, Ivo, primary, Augustin, Marinela, primary, Aulitzky, Walter E., primary, Hohenberger, Peter, primary, Kroiss, Matthias, primary, Schirmacher, Peter, primary, Schlenk, Richard F., primary, Keilholz, Ulrich, primary, Klauschen, Frederick, primary, Folprecht, Gunnar, primary, Bauer, Sebastian, primary, Siveke, Jens Thomas, primary, Brandts, Christian H., primary, Kindler, Thomas, primary, Boerries, Melanie, primary, Illert, Anna L., primary, von Bubnoff, Nikolas, primary, Jost, Philipp J., primary, Spiekermann, Karsten, primary, Bitzer, Michael, primary, Schulze-Osthoff, Klaus, primary, von Kalle, Christof, primary, Klink, Barbara, primary, Brors, Benedikt, primary, Stenzinger, Albrecht, primary, Schröck, Evelin, primary, Hübschmann, Daniel, primary, Weichert, Wilko, primary, Glimm, Hanno, primary, and Fröhling, Stefan, primary

Published
2023
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25. Supplementary Methods from Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers

Author

Horak, Peter, primary, Heining, Christoph, primary, Kreutzfeldt, Simon, primary, Hutter, Barbara, primary, Mock, Andreas, primary, Hüllein, Jennifer, primary, Fröhlich, Martina, primary, Uhrig, Sebastian, primary, Jahn, Arne, primary, Rump, Andreas, primary, Gieldon, Laura, primary, Möhrmann, Lino, primary, Hanf, Dorothea, primary, Teleanu, Veronica, primary, Heilig, Christoph E., primary, Lipka, Daniel B., primary, Allgäuer, Michael, primary, Ruhnke, Leo, primary, Laßmann, Andreas, primary, Endris, Volker, primary, Neumann, Olaf, primary, Penzel, Roland, primary, Beck, Katja, primary, Richter, Daniela, primary, Winter, Ulrike, primary, Wolf, Stephan, primary, Pfütze, Katrin, primary, Geörg, Christina, primary, Meißburger, Bettina, primary, Buchhalter, Ivo, primary, Augustin, Marinela, primary, Aulitzky, Walter E., primary, Hohenberger, Peter, primary, Kroiss, Matthias, primary, Schirmacher, Peter, primary, Schlenk, Richard F., primary, Keilholz, Ulrich, primary, Klauschen, Frederick, primary, Folprecht, Gunnar, primary, Bauer, Sebastian, primary, Siveke, Jens Thomas, primary, Brandts, Christian H., primary, Kindler, Thomas, primary, Boerries, Melanie, primary, Illert, Anna L., primary, von Bubnoff, Nikolas, primary, Jost, Philipp J., primary, Spiekermann, Karsten, primary, Bitzer, Michael, primary, Schulze-Osthoff, Klaus, primary, von Kalle, Christof, primary, Klink, Barbara, primary, Brors, Benedikt, primary, Stenzinger, Albrecht, primary, Schröck, Evelin, primary, Hübschmann, Daniel, primary, Weichert, Wilko, primary, Glimm, Hanno, primary, and Fröhling, Stefan, primary

Published
2023
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26. Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Author

Prestipino, Alessandro, Emhardt, Alica J., Aumann, Konrad, O’Sullivan, David, Gorantla, Sivahari P., Duquesne, Sandra, Melchinger, Wolfgang, Braun, Lukas, Vuckovic, Slavica, Boerries, Melanie, Busch, Hauke, Halbach, Sebastian, Pennisi, Sandra, Poggio, Teresa, Apostolova, Petya, Veratti, Pia, Hettich, Michael, Niedermann, Gabriele, Bartholomä, Mark, Shoumariyeh, Khalid, Jutzi, Jonas S., Wehrle, Julius, Dierks, Christine, Becker, Heiko, Schmitt-Graeff, Annette, Follo, Marie, Pfeifer, Dietmar, Rohr, Jan, Fuchs, Sebastian, Ehl, Stephan, Hartl, Frederike A., Minguet, Susana, Miething, Cornelius, Heidel, Florian H., Kröger, Nicolaus, Triviai, Ioanna, Brummer, Tilman, Finke, Jürgen, Illert, Anna L., Ruggiero, Eliana, Bonini, Chiara, Duyster, Justus, Pahl, Heike L., Lane, Steven W., Hill, Geoffrey R., Blazar, Bruce R., von Bubnoff, Nikolas, Pearce, Erika L., and Zeiser, Robert

Published
2018
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27. Profile of the Multicenter Cohort of the German Cancer Consortium’s Clinical Communication Platform

Author

Maier, Daniel, primary, Vehreschild, Jörg Janne, additional, Uhl, Barbara, additional, Meyer, Sandra, additional, Berger-Thürmel, Karin, additional, Boerries, Melanie, additional, Braren, Rikmer, additional, Grünwald, Viktor, additional, Hadaschik, Boris, additional, Palm, Stefan, additional, Singer, Susanne, additional, Stuschke, Martin, additional, Juárez, David, additional, Delpy, Pierre, additional, Lambarki, Mohammed, additional, Hummel, Michael, additional, Engels, Cäcilia, additional, Andreas, Stefanie, additional, Gökbuget, Nicola, additional, Ihrig, Kristina, additional, Burock, Susen, additional, Keune, Dietmar, additional, Eggert, Angelika, additional, Keilholz, Ulrich, additional, Schulz, Hagen, additional, Büttner, Daniel, additional, Löck, Steffen, additional, Krause, Mechthild, additional, Esins, Mirko, additional, Ressing, Frank, additional, Schuler, Martin, additional, Brandts, Christian, additional, Brucker, Daniel P, additional, Husmann, Gabriele, additional, Oellerich, Thomas, additional, Metzger, Patrick, additional, Voigt, Frederik, additional, Illert, Anna L, additional, Theobald, Matthias, additional, Kindler, Thomas, additional, Sudhof, Ursula, additional, Reckmann, Achim, additional, Schwinghammer, Felx, additional, Nasseh, Daniel, additional, Weichert, Wilko, additional, von Bergwelt-Baildon, Michael, additional, Bitzer, Michael, additional, Malek, Nisar, additional, Öner, Öznur, additional, Schulze-Osthoff, Klaus, additional, Bartels, Stefan, additional, Haier, Jörg, additional, Ammann, Raimund, additional, Schmidt, Anja Franziska, additional, Guenther, Bernd, additional, Janning, Melanie, additional, Kasper, Bernd, additional, Loges, Sonja, additional, Stilgenbauer, Stephan, additional, Kuhn, Peter, additional, Tausch, Eugen, additional, Runow, Silvana, additional, Kerscher, Alexander, additional, Neumann, Michael, additional, Breu, Martin, additional, Lablans, Martin, additional, and Serve, Hubert, additional

Published
2023
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28. Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation

Author

Ho, Jenny N H G, Schmidt, Dominik, Lowinus, Theresa, Ryoo, Jeongmin, Dopfer, Elaine-Pashupati, Gonzalo Núñez, Nicolás, Costa-Pereira, Sara, Toffalori, Cristina, Punta, Marco, Fetsch, Viktor, Wertheimer, Tobias, Rittmann, Marie-Claire, Braun, Lukas M, Follo, Marie, Briere, Christelle, Vinnakota, Janaki Manoja, Langenbach, Marlene, Koppers, Felicitas, Shoumariyeh, Khalid, Engel, Helena, Rückert, Tamina, Märklin, Melanie, Holzmayer, Samuel, Illert, Anna L, Magon, Federica, Andrieux, Geoffroy, Duquesne, Sandra, Pfeifer, Dietmar, Staniek, Julian, Rizzi, Marta, et al, and University of Zurich

Subjects
1307 Cell Biology, 2403 Immunology, 1303 Biochemistry, 2720 Hematology, 570 Life sciences, biology, 610 Medicine & health, 10263 Institute of Experimental Immunology
Published
2022

29. Bcl‐x Las prognostic marker and potential therapeutic target in cholangiocarcinoma

Author

Hoffmeister‐Wittmann, Paula, primary, Mock, Andreas, additional, Nichetti, Federico, additional, Korell, Felix, additional, Heilig, Christoph E., additional, Scherr, Anna‐Lena, additional, Günther, Michael, additional, Albrecht, Thomas, additional, Kelmendi, Eblina, additional, Xu, Kaiyu, additional, Nader, Luisa, additional, Kessler, Annika, additional, Schmitt, Nathalie, additional, Fritzsche, Sarah, additional, Weiler, Sofia, additional, Sobol, Benjamin, additional, Stenzinger, Albrecht, additional, Boeck, Stefan, additional, Westphalen, Christoph B., additional, Schulze‐Osthoff, Klaus, additional, Trojan, Jörg, additional, Kindler, Thomas, additional, Weichert, Wilko, additional, Spiekermann, Karsten, additional, Bitzer, Michael, additional, Folprecht, Gunnar, additional, Illert, Anna L., additional, Boerries, Melanie, additional, Klauschen, Frederick, additional, Ochsenreither, Sebastian, additional, Siveke, Jens, additional, Bauer, Sebastian, additional, Glimm, Hanno, additional, Brors, Benedikt, additional, Hüllein, Jennifer, additional, Hübschmann, Daniel, additional, Uhrig, Sebastian, additional, Horak, Peter, additional, Kreutzfeldt, Simon, additional, Banales, Jesus M., additional, Springfeld, Christoph, additional, Jäger, Dirk, additional, Schirmacher, Peter, additional, Roessler, Stephanie, additional, Ormanns, Steffen, additional, Goeppert, Benjamin, additional, Fröhling, Stefan, additional, and Köhler, Bruno C., additional

Published
2022
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30. Trailblazing precision medicine in Europe: A joint view by Genomic Medicine Sweden and the Centers for Personalized Medicine, ZPM, in Germany

Author

Stenzinger, Albrecht, primary, Edsjö, Anders, additional, Ploeger, Carolin, additional, Friedman, Mikaela, additional, Fröhling, Stefan, additional, Wirta, Valtteri, additional, Seufferlein, Thomas, additional, Botling, Johan, additional, Duyster, Justus, additional, Akhras, Michael, additional, Thimme, Robert, additional, Fioretos, Thoas, additional, Bitzer, Michael, additional, Cavelier, Lucia, additional, Schirmacher, Peter, additional, Malek, Nisar, additional, Rosenquist, Richard, additional, Lindstrand, Anna, additional, Wedell, Anna, additional, Gisselsson, David, additional, Melén, Erik, additional, Helenius, Gisela, additional, Ehrencrona, Hans, additional, Engstrand, Lars, additional, Palmqvist, Lars, additional, Levin, Lars-Åke, additional, Lovmar, Lovisa, additional, Landström, Maréne, additional, Hallbeck, Martin, additional, Wadelius, Mia, additional, Sikora, Per, additional, Beer, Ambros J., additional, Illert, Anna L., additional, Budczies, Jan, additional, Nikolaou, Konstantin, additional, Kohlbacher, Oliver, additional, Horak, Peter, additional, Kuhn, Peter, additional, Schroeder, Christopher, additional, Boerries, Melanie, additional, Lassmann, Silke, additional, and Gaidzik, Verena I., additional

Published
2022
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31. Gene expression-based prediction of pazopanib efficacy in sarcoma

Author

Heilig, Christoph E., primary, Laßmann, Andreas, additional, Mughal, Sadaf S., additional, Mock, Andreas, additional, Pirmann, Sebastian, additional, Teleanu, Veronica, additional, Renner, Marcus, additional, Andresen, Carolin, additional, Köhler, Bruno C., additional, Aybey, Bogac, additional, Bauer, Sebastian, additional, Siveke, Jens T., additional, Hamacher, Rainer, additional, Folprecht, Gunnar, additional, Richter, Stephan, additional, Schröck, Evelin, additional, Brandts, Christian H., additional, Ahrens, Marit, additional, Hohenberger, Peter, additional, Egerer, Gerlinde, additional, Kindler, Thomas, additional, Boerries, Melanie, additional, Illert, Anna L., additional, von Bubnoff, Nikolas, additional, Apostolidis, Leonidas, additional, Jost, Philipp J., additional, Westphalen, C. Benedikt, additional, Weichert, Wilko, additional, Keilholz, Ulrich, additional, Klauschen, Frederick, additional, Beck, Katja, additional, Winter, Ulrike, additional, Richter, Daniela, additional, Möhrmann, Lino, additional, Bitzer, Michael, additional, Schulze-Osthoff, Klaus, additional, Brors, Benedikt, additional, Mechtersheimer, Gunhild, additional, Kreutzfeldt, Simon, additional, Heining, Christoph, additional, Lipka, Daniel B., additional, Stenzinger, Albrecht, additional, Schlenk, Richard F., additional, Horak, Peter, additional, Glimm, Hanno, additional, Hübschmann, Daniel, additional, and Fröhling, Stefan, additional

Published
2022
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33. Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group 'Molecular Diagnostics and Therapy (vol 135, pg 1, 2020)

Author

Westphalen, C. Benedikt, Bokemeyer, Carsten, Buettner, Reinhard, Froehling, Stefan, Gaidzik, Verena I., Glimm, Hanno, Hacker, Ulrich T., Heinemann, Volker, Illert, Anna L., Keilholz, Ulrich, Kindler, Thomas, Kirschner, Martin, Schilling, Bastian, Siveke, Jens T., Schroeder, Thomas, Tischler, Verena, Wagner, Sebastian, Weichert, Wilko, Zips, Daniel, Loges, Sonja, Westphalen, C. Benedikt, Bokemeyer, Carsten, Buettner, Reinhard, Froehling, Stefan, Gaidzik, Verena I., Glimm, Hanno, Hacker, Ulrich T., Heinemann, Volker, Illert, Anna L., Keilholz, Ulrich, Kindler, Thomas, Kirschner, Martin, Schilling, Bastian, Siveke, Jens T., Schroeder, Thomas, Tischler, Verena, Wagner, Sebastian, Weichert, Wilko, Zips, Daniel, and Loges, Sonja

Published
2022

34. Corrigendum to “Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’” [European Journal of Cancer 135 (2020) 1-7]

Author

Benedikt Westphalen, C., primary, Bokemeyer, Carsten, additional, Büttner, Reinhard, additional, Fröhling, Stefan, additional, Gaidzik, Verena I., additional, Glimm, Hanno, additional, Hacker, Ulrich T., additional, Heinemann, Volker, additional, Illert, Anna L., additional, Keilholz, Ulrich, additional, Kindler, Thomas, additional, Kirschner, Martin, additional, Schilling, Bastian, additional, Siveke, Jens T., additional, Schroeder, Thomas, additional, Tischler, Verena, additional, Wagner, Sebastian, additional, Weichert, Wilko, additional, Zips, Daniel, additional, Loges, Sonja, additional, Bargou (Würzburg), Ralf, additional, Bläker (Leipzig), Hendrik, additional, Börries (Freiburg), Melanie, additional, Brandts (Frankfurt), Christian, additional, von Bubnoff (Freiburg), Nikolas, additional, Demes (Frankfurt), Melanie, additional, Desuki (Mainz), Alexander, additional, Döhner (Ulm), Hartmut, additional, Duyster (Freiburg), Justus, additional, Gaisa (Aachen), Nadine, additional, Heine (Bonn), Annkristin, additional, Heining (Dresden), Christoph, additional, Horak (Heidelberg), Peter, additional, Jelas (Berlin), Ivan, additional, Jost (München), Philipp J., additional, Jung (München), Andreas, additional, Kirchner (München), Thomas, additional, Klauschen (Berlin), Frederick, additional, Kreutzfeldt (Heidelberg), Simon, additional, Kumbrink (München), Jörg, additional, Kunzmann (Würzburg), Volker, additional, Lassmann (Freiburg), Silke, additional, Metzeler (München), Klaus, additional, Möller (Ulm), Peter, additional, Ortiz-Brüchle (Aachen), Nadina, additional, Paret (Mainz), Claudia, additional, Pelusi (Bonn), Natalie, additional, Peters (Freiburg), Christoph, additional, Pfarr (München), Nicole, additional, Richter (Dresden), Daniela, additional, Riedmann (München), Kristina, additional, Rieke (Berlin), Damian, additional, Ritzel (Mainz), Christoph, additional, Schadendorf (Essen), Dirk, additional, Schildhaus (Essen), Hans-Ulrich, additional, Schorle (Bonn), Hubert, additional, Seufferlein (Ulm), Thomas, additional, Simon (Hamburg), Ronald, additional, Stenzinger (Heidelberg), Albrecht, additional, Tabatabai (Tübingen), Ghazaleh, additional, Velthaus (Hamburg), Janna-Lisa, additional, Werner (Freiburg), Martin, additional, Wild (Frankfurt), Peter J., additional, and Wolf (Köln), Jürgen, additional

Published
2022
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35. Corrigendum to 'Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group Molecular Diagnostics and Therapy'

Author

Westphalen, C. Benedikt, Bokemeyer, Carsten, Büttner, Reinhard, Fröhling, Stefan, Gaidzik, Verena I., Glimm, Hanno, Hacker, Ulrich T., Heinemann, Volker, Illert, Anna L., Keilholz, Ulrich, Kindler, Thomas, Kirschner, Martin, Schilling, Bastian, Siveke, Jens, Schroeder, Thomas, Tischler, Verena, Wagner, Sebastian, Weichert, Wilko, Zips, Daniel, Loges, Sonja, Schadendorf, Dirk, and Schildhaus, Hans-Ulrich

Subjects
Medizin
Abstract

Korrektur zu 10.1016/j.ejca.2020.04.019

Published
2022

37. The IL-3, IL-5, and GM-CSF common receptor beta chain mediates oncogenic activity of FLT3-ITD-positive AML

Author

Charlet, Anne, primary, Kappenstein, Max, additional, Keye, Philip, additional, Kläsener, Kathrin, additional, Endres, Cornelia, additional, Poggio, Teresa, additional, Gorantla, Sivahari P., additional, Kreutmair, Stefanie, additional, Sänger, Jana, additional, Illert, Anna L., additional, Miething, Cornelius, additional, Reth, Michael, additional, Duyster, Justus, additional, Rummelt, Christoph, additional, and von Bubnoff, Nikolas, additional

Published
2021
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38. Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers

Author

Horak, Peter, primary, Heining, Christoph, additional, Kreutzfeldt, Simon, additional, Hutter, Barbara, additional, Mock, Andreas, additional, Hüllein, Jennifer, additional, Fröhlich, Martina, additional, Uhrig, Sebastian, additional, Jahn, Arne, additional, Rump, Andreas, additional, Gieldon, Laura, additional, Möhrmann, Lino, additional, Hanf, Dorothea, additional, Teleanu, Veronica, additional, Heilig, Christoph E., additional, Lipka, Daniel B., additional, Allgäuer, Michael, additional, Ruhnke, Leo, additional, Laßmann, Andreas, additional, Endris, Volker, additional, Neumann, Olaf, additional, Penzel, Roland, additional, Beck, Katja, additional, Richter, Daniela, additional, Winter, Ulrike, additional, Wolf, Stephan, additional, Pfütze, Katrin, additional, Geörg, Christina, additional, Meißburger, Bettina, additional, Buchhalter, Ivo, additional, Augustin, Marinela, additional, Aulitzky, Walter E., additional, Hohenberger, Peter, additional, Kroiss, Matthias, additional, Schirmacher, Peter, additional, Schlenk, Richard F., additional, Keilholz, Ulrich, additional, Klauschen, Frederick, additional, Folprecht, Gunnar, additional, Bauer, Sebastian, additional, Siveke, Jens Thomas, additional, Brandts, Christian H., additional, Kindler, Thomas, additional, Boerries, Melanie, additional, Illert, Anna L., additional, von Bubnoff, Nikolas, additional, Jost, Philipp J., additional, Spiekermann, Karsten, additional, Bitzer, Michael, additional, Schulze-Osthoff, Klaus, additional, von Kalle, Christof, additional, Klink, Barbara, additional, Brors, Benedikt, additional, Stenzinger, Albrecht, additional, Schröck, Evelin, additional, Hübschmann, Daniel, additional, Weichert, Wilko, additional, Glimm, Hanno, additional, and Fröhling, Stefan, additional

Published
2021
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39. Transitioning the Molecular Tumor Board from Proof of Concept to Clinical Routine: A German Single-Center Analysis

Author

Hoefflin, Rouven, primary, Lazarou, Adriana, additional, Hess, Maria Elena, additional, Reiser, Meike, additional, Wehrle, Julius, additional, Metzger, Patrick, additional, Frey, Anna Verena, additional, Becker, Heiko, additional, Aumann, Konrad, additional, Berner, Kai, additional, Boeker, Martin, additional, Buettner, Nico, additional, Dierks, Christine, additional, Duque-Afonso, Jesus, additional, Eisenblaetter, Michel, additional, Erbes, Thalia, additional, Fritsch, Ralph, additional, Ge, Isabell Xiang, additional, Geißler, Anna-Lena, additional, Grabbert, Markus, additional, Heeg, Steffen, additional, Heiland, Dieter Henrik, additional, Hettmer, Simone, additional, Kayser, Gian, additional, Keller, Alexander, additional, Kleiber, Anita, additional, Kutilina, Alexandra, additional, Mehmed, Leman, additional, Meiss, Frank, additional, Poxleitner, Philipp, additional, Rawluk, Justyna, additional, Ruf, Juri, additional, Schäfer, Henning, additional, Scherer, Florian, additional, Shoumariyeh, Khalid, additional, Tzschach, Andreas, additional, Peters, Christoph, additional, Brummer, Tilman, additional, Werner, Martin, additional, Duyster, Justus, additional, Lassmann, Silke, additional, Miething, Cornelius, additional, Boerries, Melanie, additional, Illert, Anna L., additional, and von Bubnoff, Nikolas, additional

Published
2021
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40. Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group 'Molecular Diagnostics and Therapy'

Author

Westphalen, Benedikt C., Bokemeyer, Carsten, Buettner, Reinhard, Froehling, Stefan, Gaidzik, Verena I., Glimm, Hanno, Hacker, Ulrich T., Heinemann, Volker, Illert, Anna L., Keilholz, Ulrich, Kindler, Thomas, Kirschner, Martin, Schilling, Bastian, Siveke, Jens T., Schroeder, Thomas, Tischler, Verena, Wagner, Sebastian, Weichert, Wilko, Zips, Daniel, Loges, Sonja, Westphalen, Benedikt C., Bokemeyer, Carsten, Buettner, Reinhard, Froehling, Stefan, Gaidzik, Verena I., Glimm, Hanno, Hacker, Ulrich T., Heinemann, Volker, Illert, Anna L., Keilholz, Ulrich, Kindler, Thomas, Kirschner, Martin, Schilling, Bastian, Siveke, Jens T., Schroeder, Thomas, Tischler, Verena, Wagner, Sebastian, Weichert, Wilko, Zips, Daniel, and Loges, Sonja

Abstract

Precision cancer medicine (PCM) holds great promises to offer more effective therapies to patients based on molecular profiling of their individual tumours. Although the PCM approach seems intuitive, multiple conceptional and structural challenges interfere with the broad implementation of PCM into clinical practice. Accordingly, concerted national and international efforts are needed to guide the further development and broad adoption of PCM in Germany. With support of the 'German Cancer Aid' (Deutsche Krebshilfe [DKH]) a task force 'Molecular Diagnostics and Therapy' was implemented. In two workshops supported by the DKH, delegates from the fourteen comprehensive cancer centresidentified key topics essential to implement quality-guided, harmonized and adaptable PCM. Based on an online questionnaire and using a modified Delphi approach, nine statements were drafted and evaluated within the group. These statements could serve as a basis to define a collaborative strategy for PCM in the future with the aim to sustain and further improve its quality. (C) 2020 Elsevier Ltd. All rights reserved.

Published
2020

41. Personalized Treatment Selection and Disease Monitoring Using Circulating Tumor DNA Profiling in Real-World Cancer Patient Management

Author

Wehrle, Julius; https://orcid.org/0000-0001-6514-4230, Philipp, Ulrike, Jolic, Martina; https://orcid.org/0000-0002-3152-2413, Follo, Marie; https://orcid.org/0000-0002-3090-7442, Hussung, Saskia, Waldeck, Silvia, Deuter, Max; https://orcid.org/0000-0002-1055-4803, Rassner, Michael; https://orcid.org/0000-0003-0964-9511, Braune, Jan, Rawluk, Justyna, Greil, Christine, Waller, Cornelius F; https://orcid.org/0000-0002-5777-0212, Becker, Heiko, Duque-Afonso, Jesús; https://orcid.org/0000-0002-8287-5673, Illert, Anna-L, Fritsch, Ralph M, Meiss, Frank; https://orcid.org/0000-0002-4044-9094, Duyster, Justus, von Bubnoff, Nikolas, Scherer, Florian, Wehrle, Julius; https://orcid.org/0000-0001-6514-4230, Philipp, Ulrike, Jolic, Martina; https://orcid.org/0000-0002-3152-2413, Follo, Marie; https://orcid.org/0000-0002-3090-7442, Hussung, Saskia, Waldeck, Silvia, Deuter, Max; https://orcid.org/0000-0002-1055-4803, Rassner, Michael; https://orcid.org/0000-0003-0964-9511, Braune, Jan, Rawluk, Justyna, Greil, Christine, Waller, Cornelius F; https://orcid.org/0000-0002-5777-0212, Becker, Heiko, Duque-Afonso, Jesús; https://orcid.org/0000-0002-8287-5673, Illert, Anna-L, Fritsch, Ralph M, Meiss, Frank; https://orcid.org/0000-0002-4044-9094, Duyster, Justus, von Bubnoff, Nikolas, and Scherer, Florian

Abstract

BACKGROUND Circulating tumor DNA (ctDNA) in the blood plasma of cancer patients is an emerging biomarker used across oncology, facilitating noninvasive disease monitoring and genetic profiling at various disease milestones. Digital droplet PCR (ddPCR) technologies have demonstrated high sensitivity and specificity for robust ctDNA detection at relatively low costs. Yet, their value for ctDNA-based management of a broad population of cancer patients beyond clinical trials remains elusive. METHODS We developed mutation-specific ddPCR assays that were optimized for their use in real-world cancer management, covering 12 genetic aberrations in common cancer genes, such as EGFR, BRAF, KIT, KRAS, and NRAS. We assessed the limit of detection (LOD) and the limit of blank (LOB) for each assay and validated their performance for ctDNA detection using matched tumor sequencing. RESULTS We applied our custom ddPCR assays to 352 plasma samples from 96 patients with solid tumors. Mutation detection in plasma was highly concordant with tumor sequencing, demonstrating high sensitivity and specificity across all assays. In 20 cases, radiographic cancer progression was mirrored by an increase of ctDNA concentrations or the occurrence of novel mutations in plasma. Moreover, ctDNA profiling at diagnosis and during disease progression reflected personalized treatment selection through the identification of actionable gene targets in 20 cases. CONCLUSION Collectively, our work highlights the potential of ctDNA assessment by sensitive ddPCR for accurate disease monitoring, robust identification of resistance mutations, and upfront treatment selection in patients with solid tumors. We envision an increasing future role for ctDNA profiling within personalized cancer management in daily clinical routine.

Published
2020

42. Personalized Treatment Selection and Disease Monitoring Using Circulating Tumor DNA Profiling in Real-World Cancer Patient Management

Author

Wehrle, Julius, primary, Philipp, Ulrike, additional, Jolic, Martina, additional, Follo, Marie, additional, Hussung, Saskia, additional, Waldeck, Silvia, additional, Deuter, Max, additional, Rassner, Michael, additional, Braune, Jan, additional, Rawluk, Justyna, additional, Greil, Christine, additional, Waller, Cornelius F., additional, Becker, Heiko, additional, Duque-Afonso, Jesús, additional, Illert, Anna L., additional, Fritsch, Ralph M., additional, Meiss, Frank, additional, Duyster, Justus, additional, von Bubnoff, Nikolas, additional, and Scherer, Florian, additional

Published
2020
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43. Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’

Author

Westphalen, C. Benedikt, primary, Bokemeyer, Carsten, additional, Büttner, Reinhard, additional, Fröhling, Stefan, additional, Gaidzik, Verena I., additional, Glimm, Hanno, additional, Hacker, Ulrich T., additional, Heinemann, Volker, additional, Illert, Anna L., additional, Keilholz, Ulrich, additional, Kindler, Thomas, additional, Kirschner, Martin, additional, Schilling, Bastian, additional, Siveke, Jens T., additional, Schroeder, Thomas, additional, Tischler, Verena, additional, Wagner, Sebastian, additional, Weichert, Wilko, additional, Zips, Daniel, additional, Loges, Sonja, additional, Bargou (Würzburg), Ralf, additional, Bläker (Leipzig), Hendrik, additional, Börries (Freiburg), Melanie, additional, Brandts (Frankfurt), Christian, additional, von Bubnoff (Lübeck), Nikolas, additional, Demes (Frankfurt), Melanie, additional, Desuki (Mainz), Alexander, additional, Döhner (Ulm), Hartmut, additional, Duyster (Freiburg), Justus, additional, Gaisa (Aachen), Nadine, additional, Heine (Bonn), Annkristin, additional, Heining (Dresden), Christoph, additional, Horak (Heidelberg), Peter, additional, Jelas (Berlin), Ivan, additional, Jost (München), Philipp J., additional, Jung (München), Andreas, additional, Kirchner (München), Thomas, additional, Klauschen (Berlin), Frederick, additional, Kreutzfeldt (Heidelberg), Simon, additional, Kumbrink (München), Jörg, additional, Kunzmann (Würzburg), Volker, additional, Lassmann (Freiburg), Silke, additional, Metzeler (München), Klaus, additional, Möller (Ulm), Peter, additional, Ortiz-Brüchle (Aachen), Nadina, additional, Paret (Mainz), Claudia, additional, Pelusi (Bonn), Natalie, additional, Peters (Freiburg), Christoph, additional, Pfarr (München), Nicole, additional, Richter (Dresden), Daniela, additional, Riedmann (München), Kristina, additional, Rieke (Berlin), Damian, additional, Ritzel (Mainz), Christoph, additional, Schadendorf (Essen), Dirk, additional, Schildhaus (Essen), Hans-Ulrich, additional, Schorle (Bonn), Hubert, additional, Seufferlein (Ulm), Thomas, additional, Simon (Hamburg), Ronald, additional, Stenzinger (Heidelberg), Albrecht, additional, Tabatabai (Tübingen), Ghazaleh, additional, Velthaus (Hamburg), Janna-Lisa, additional, Werner (Freiburg), Martin, additional, Wild (Frankfurt), Peter J., additional, and Wolf (Köln), Jürgen, additional

Published
2020
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44. A novel conditional NPM-ALK-driven model of CD30+ T-cell lymphoma mediated by a translational stop cassette

Author

Shoumariyeh, Khalid, primary, Schneider, Nicolas, additional, Poggio, Teresa, additional, Veratti, Pia, additional, Ehrenfeld, Sophia, additional, Redhaber, Desiree M., additional, Khan, Robin, additional, Pfeifer, Dietmar, additional, Klingeberg, Cathrin, additional, Kreutmair, Stefanie, additional, Rudelius, Martina, additional, Quintanilla-Martinez, Leticia, additional, Fend, Falko, additional, Illert, Anna L., additional, Duyster, Justus, additional, and Miething, Cornelius, additional

Published
2019
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45. Erratum : Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Author

Mathew, Nimitha R, Baumgartner, Francis, Braun, Lukas, O'Sullivan, David, Thomas, Simone, Waterhouse, Miguel, Müller, Tony A, Hanke, Kathrin, Taromi, Sanaz, Apostolova, Petya, Illert, Anna L, Melchinger, Wolfgang, Duquesne, Sandra, Schmitt-Graeff, Annette, Osswald, Lena, Yan, Kai-Li, Weber, Arnim, Tugues, Sonia, Spath, Sabine, Pfeifer, Dietmar, Follo, Marie, Claus, Rainer, Lübbert, Michael, Rummelt, Christoph, Bertz, Hartmut, Wäsch, Ralph, Haag, Johanna, Schmidts, Andrea, Schultheiss, Michael, Bettinger, Dominik, Thimme, Robert, Ullrich, Evelyn, Tanriver, Yakup, Vuong, Giang Lam, Arnold, Renate, Hemmati, Philipp, Wolf, Dominik, Ditschkowski, Markus, Jilg, Cordula, Wilhelm, Konrad, Leiber, Christian, Gerull, Sabine, Halter, Jörg, Lengerke, Claudia, Pabst, Thomas, Schroeder, Thomas, Kobbe, Guido, Rösler, Wolf, Doostkam, Soroush, Meckel, Stephan, Stabla, Kathleen, Metzelder, Stephan K, Halbach, Sebastian, Brummer, Tilman, Hu, Zehan, Dengjel, Joern, Hackanson, Björn, Schmid, Christoph, Holtick, Udo, Scheid, Christof, Spyridonidis, Alexandros, Stölzel, Friedrich, Ordemann, Rainer, Müller, Lutz P, Sicre-de-Fontbrune, Flore, Ihorst, Gabriele, Kuball, Jürgen, Ehlert, Jan E, Feger, Daniel, Wagner, Eva-Maria, Cahn, Jean-Yves, Schnell, Jacqueline, Kuchenbauer, Florian, Bunjes, Donald, Chakraverty, Ronjon, Richardson, Simon, Gill, Saar, Kröger, Nicolaus, Ayuk, Francis, Vago, Luca, Ciceri, Fabio, Müller, Antonia M, Kondo, Takeshi, Teshima, Takanori, Klaeger, Susan, Kuster, Bernhard, Kim, Dennis Dong Hwan, Weisdorf, Daniel, van der Velden, Walter, Dörfel, Daniela, Bethge, Wolfgang, Hilgendorf, Inken, Hochhaus, Andreas, Andrieux, Geoffroy, Börries, Melanie, Busch, Hauke, Magenau, John, Reddy, Pavan, Labopin, Myriam, Antin, Joseph H, Henden, Andrea S, Hill, Geoffrey R, Kennedy, Glen A, Bar, Merav, Sarma, Anita, McLornan, Donal, Mufti, Ghulam, Oran, Betul, Rezvani, Katayoun, Shah, Omid, Negrin, Robert S, Nagler, Arnon, Prinz, Marco, Burchert, Andreas, Neubauer, Andreas, Beelen, Dietrich, Mackensen, Andreas, von Bubnoff, Nikolas, Herr, Wolfgang, Becher, Burkhard, Socié, Gerard, Caligiuri, Michael A, Ruggiero, Eliana, Bonini, Chiara, Häcker, Georg, Duyster, Justus, Finke, Jürgen, Pearce, Erika, Blazar, Bruce R, and Zeiser, Robert

Abstract

This corrects the article DOI: 10.1038/nm.4484.

Published
2018

46. Corrigendum: Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells

Author

Gharun, Kourosh, Senges, Julia, Seidl, Maximilian, Lösslein, Anne, Kolter, Julia, Lohrmann, Florens, Fliegauf, Manfred, Elgizouli, Magdeldin, Alber, Marco, Vavra, Martina, Schachtrup, Kristina, Illert, Anna L, Gilleron, Martine, Kirschning, Carsten Jürgen, Triantafyllopoulou, Antigoni, and Henneke, Philipp

Subjects
Medizin
Abstract

The authors regret omitting Marco Alber as an author on this paper, whose contributions led to figure 5C. The authors apologize for this oversight and have updated the author contributions to include: MA performed and analyzed the internalization assays.

Published
2018

48. Phosphorylation of BECLIN-1 by BCR-ABL suppresses autophagy in chronic myeloid leukemia

Author

Yu, Chuanjiang, primary, Gorantla, Sivahari P., additional, Müller-Rudorf, Alina, additional, Müller, Tony A., additional, Kreutmair, Stefanie, additional, Albers, Corinna, additional, Jakob, Lena, additional, Lippert, Lena J., additional, Yue, Zhenyu, additional, Engelhardt, Monika, additional, Follo, Marie, additional, Zeiser, Robert, additional, Huber, Tobias B., additional, Duyster, Justus, additional, and Illert, Anna L., additional

Published
2019
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49. Mycobacteria exploit nitric oxide‐induced transformation of macrophages into permissive giant cells

Author

Gharun, Kourosh, primary, Senges, Julia, additional, Seidl, Maximilian, additional, Lösslein, Anne, additional, Kolter, Julia, additional, Lohrmann, Florens, additional, Fliegauf, Manfred, additional, Elgizouli, Magdeldin, additional, Alber, Marco, additional, Vavra, Martina, additional, Schachtrup, Kristina, additional, Illert, Anna L, additional, Gilleron, Martine, additional, Kirschning, Carsten J, additional, Triantafyllopoulou, Antigoni, additional, and Henneke, Philipp, additional

Published
2018
Full Text
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50. Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Author

CTI Kuball, MS Hematologie, Cancer, Regenerative Medicine and Stem Cells, Infection & Immunity, Mathew, Nimitha R, Baumgartner, Francis, Braun, Lukas, O'Sullivan, David, Thomas, Simone, Waterhouse, Miguel, Müller, Tony A, Hanke, Kathrin, Taromi, Sanaz, Apostolova, Petya, Illert, Anna L, Melchinger, Wolfgang, Duquesne, Sandra, Schmitt-Graeff, Annette, Osswald, Lena, Yan, Kai-Li, Weber, Arnim, Tugues, Sonia, Spath, Sabine, Pfeifer, Dietmar, Follo, Marie, Claus, Rainer, Lübbert, Michael, Rummelt, Christoph, Bertz, Hartmut, Wäsch, Ralph, Haag, Johanna, Schmidts, Andrea, Schultheiss, Michael, Bettinger, Dominik, Thimme, Robert, Ullrich, Evelyn, Tanriver, Yakup, Vuong, Giang Lam, Arnold, Renate, Hemmati, Philipp, Wolf, Dominik, Ditschkowski, Markus, Jilg, Cordula, Wilhelm, Konrad, Leiber, Christian, Gerull, Sabine, Halter, Jörg, Lengerke, Claudia, Pabst, Thomas, Schroeder, Thomas, Kobbe, Guido, Rösler, Wolf, Doostkam, Soroush, Meckel, Stephan, Stabla, Kathleen, Metzelder, Stephan K, Halbach, Sebastian, Brummer, Tilman, Hu, Zehan, Dengjel, Joern, Hackanson, Björn, Schmid, Christoph, Holtick, Udo, Scheid, Christof, Spyridonidis, Alexandros, Stölzel, Friedrich, Ordemann, Rainer, Müller, Lutz P, Sicre-de-Fontbrune, Flore, Ihorst, Gabriele, Kuball, Jürgen, Ehlert, Jan E, Feger, Daniel, Wagner, Eva-Maria, Cahn, Jean-Yves, Schnell, Jacqueline, Kuchenbauer, Florian, Bunjes, Donald, Chakraverty, Ronjon, Richardson, Simon, Gill, Saar, Kröger, Nicolaus, Ayuk, Francis, Vago, Luca, Ciceri, Fabio, Müller, Antonia M, Kondo, Takeshi, Teshima, Takanori, Klaeger, Susan, Kuster, Bernhard, Kim, Dennis Dong Hwan, Weisdorf, Daniel, van der Velden, Walter, Dörfel, Daniela, Bethge, Wolfgang, Hilgendorf, Inken, Hochhaus, Andreas, Andrieux, Geoffroy, Börries, Melanie, Busch, Hauke, Magenau, John, Reddy, Pavan, Labopin, Myriam, Antin, Joseph H, Henden, Andrea S, Hill, Geoffrey R, Kennedy, Glen A, Bar, Merav, Sarma, Anita, McLornan, Donal, Mufti, Ghulam, Oran, Betul, Rezvani, Katayoun, Shah, Omid, Negrin, Robert S, Nagler, Arnon, Prinz, Marco, Burchert, Andreas, Neubauer, Andreas, Beelen, Dietrich, Mackensen, Andreas, von Bubnoff, Nikolas, Herr, Wolfgang, Becher, Burkhard, Socié, Gerard, Caligiuri, Michael A, Ruggiero, Eliana, Bonini, Chiara, Häcker, Georg, Duyster, Justus, Finke, Jürgen, Pearce, Erika, Blazar, Bruce R, Zeiser, Robert, CTI Kuball, MS Hematologie, Cancer, Regenerative Medicine and Stem Cells, Infection & Immunity, Mathew, Nimitha R, Baumgartner, Francis, Braun, Lukas, O'Sullivan, David, Thomas, Simone, Waterhouse, Miguel, Müller, Tony A, Hanke, Kathrin, Taromi, Sanaz, Apostolova, Petya, Illert, Anna L, Melchinger, Wolfgang, Duquesne, Sandra, Schmitt-Graeff, Annette, Osswald, Lena, Yan, Kai-Li, Weber, Arnim, Tugues, Sonia, Spath, Sabine, Pfeifer, Dietmar, Follo, Marie, Claus, Rainer, Lübbert, Michael, Rummelt, Christoph, Bertz, Hartmut, Wäsch, Ralph, Haag, Johanna, Schmidts, Andrea, Schultheiss, Michael, Bettinger, Dominik, Thimme, Robert, Ullrich, Evelyn, Tanriver, Yakup, Vuong, Giang Lam, Arnold, Renate, Hemmati, Philipp, Wolf, Dominik, Ditschkowski, Markus, Jilg, Cordula, Wilhelm, Konrad, Leiber, Christian, Gerull, Sabine, Halter, Jörg, Lengerke, Claudia, Pabst, Thomas, Schroeder, Thomas, Kobbe, Guido, Rösler, Wolf, Doostkam, Soroush, Meckel, Stephan, Stabla, Kathleen, Metzelder, Stephan K, Halbach, Sebastian, Brummer, Tilman, Hu, Zehan, Dengjel, Joern, Hackanson, Björn, Schmid, Christoph, Holtick, Udo, Scheid, Christof, Spyridonidis, Alexandros, Stölzel, Friedrich, Ordemann, Rainer, Müller, Lutz P, Sicre-de-Fontbrune, Flore, Ihorst, Gabriele, Kuball, Jürgen, Ehlert, Jan E, Feger, Daniel, Wagner, Eva-Maria, Cahn, Jean-Yves, Schnell, Jacqueline, Kuchenbauer, Florian, Bunjes, Donald, Chakraverty, Ronjon, Richardson, Simon, Gill, Saar, Kröger, Nicolaus, Ayuk, Francis, Vago, Luca, Ciceri, Fabio, Müller, Antonia M, Kondo, Takeshi, Teshima, Takanori, Klaeger, Susan, Kuster, Bernhard, Kim, Dennis Dong Hwan, Weisdorf, Daniel, van der Velden, Walter, Dörfel, Daniela, Bethge, Wolfgang, Hilgendorf, Inken, Hochhaus, Andreas, Andrieux, Geoffroy, Börries, Melanie, Busch, Hauke, Magenau, John, Reddy, Pavan, Labopin, Myriam, Antin, Joseph H, Henden, Andrea S, Hill, Geoffrey R, Kennedy, Glen A, Bar, Merav, Sarma, Anita, McLornan, Donal, Mufti, Ghulam, Oran, Betul, Rezvani, Katayoun, Shah, Omid, Negrin, Robert S, Nagler, Arnon, Prinz, Marco, Burchert, Andreas, Neubauer, Andreas, Beelen, Dietrich, Mackensen, Andreas, von Bubnoff, Nikolas, Herr, Wolfgang, Becher, Burkhard, Socié, Gerard, Caligiuri, Michael A, Ruggiero, Eliana, Bonini, Chiara, Häcker, Georg, Duyster, Justus, Finke, Jürgen, Pearce, Erika, Blazar, Bruce R, and Zeiser, Robert

Published
2018

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