1. Imaging to study solid tumour origin and progression: lessons from research and clinical oncology
- Author
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Giovanni Zito, Stefania Raimondo, Raimondo, S., and Zito, G.
- Subjects
Diagnostic Imaging ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Pathology ,education ,Immunology ,Biology ,Medical Oncology ,Multimodal Imaging ,03 medical and health sciences ,0302 clinical medicine ,Cancer stem cell ,Neoplasms ,Internal medicine ,medicine ,Animals ,Humans ,Immunology and Allergy ,Molecular Targeted Therapy ,Solid tumour ,Clinical Oncology ,Research ,Optical Imaging ,Cell Biology ,Imaging, cell biology, cancer stem cells ,Molecular Imaging ,Cell Transformation, Neoplastic ,030104 developmental biology ,030220 oncology & carcinogenesis ,Disease Progression ,Neoplastic Stem Cells - Abstract
Biomedical imaging in recent decades has clarified our understanding of normal and pathological cellular processes in vivo. In particular, this approach recently provided insights into processes occurring at a molecular or genetic level rather than at the anatomical level. The evolution of this discipline by engineering have led to its integration into biomedical research to (1) increase sensitivity and resolution imaging and to (2) improve tissue and cell specificity. Currently, imaging approaches are used in three different biomedical areas: (a) identification of cellular processes in physiological and disease state; (b) in vivo single-cell imaging; and (c) identification of new prognostic and therapeutical strategies. In this review, we will focus on the state of art of biomedical imaging in cancer. Specifically, we will highlight the most important advances in imaging tools available for basic and translational cancer research, with a particular emphasis on solid tissue malignancies.Immunology and Cell Biology advance online publication, 4 April 2017; doi:10.1038/icb.2017.17.
- Published
- 2017