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1. Recipients of public assistance with advanced chronic kidney disease: insights into receiving a presentation of kidney replacement therapy options and polypharmacy from Japanese investigators with innovative network about kidney disease study

Author

Nakamura, Yoshihiro, Sasaki, Sho, Imaizumi, Takahiro, Nishiwaki, Hiroki, Murakami, Minoru, Yazawa, Masahiko, Raita, Yoshihiko, Kawarazaki, Hiroo, Shimizu, Hideaki, Saka, Yosuke, Takizawa, Naoho, and Fujita, Yoshiro

Published
2024
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6. Prevalence and Risk Factors of Insomnia and Sleep-aid Use in Emergency Physicians in Japan: Secondary Analysis of a Nationwide Survey

Author

Chiba, Takuyo, Hagiwara, Yusuke, Hifumi, Toru, Kuroda, Yasuhiro, Ikeda, Shunya, Khoujah, Danya, Imaizumi, Takahiro, and Shiga, Takashi

Subjects
burnout, insomnia, graduate medical education, substance-related disorders
Abstract

Introduction: Emergency physicians (EP) are suspected to have a high prevalence of insomnia and sleep-aid use. Most prior studies about sleep-aid use in EPs have been limited by low response rates. In this study our aim was to investigate the prevalence of insomnia and sleep-aid use among early-career Japanese EPs and assess the factors associated with insomnia and sleep-aid use.Methods: We collected anonymous, voluntary, survey-based data regarding chronic insomnia and sleep-aid use from board-eligible EPs taking the initial Japanese Association of Acute Medicine board certification exam in 2019 and 2020. We describe the prevalence of insomnia and sleep-aid use and analyzed demographic and job-related factors using multivariable logistic regression analysis.Results: The response rate was 89.71% (732 of 816). The prevalence of chronic insomnia and sleep-aid use was 24.89% (95% CI 21.78-28.29%) and 23.77% (95% CI 20.69-27.15%), respectively. Factors associated with chronic insomnia were long working hours (odds ratio [OR] 1.02, 1.01-1.03, per one-hour/week), and “stress factor” (OR 1.46, 1.13-1.90). Factors associated with sleep-aid use were male gender (OR 1.71, 1.03-2.86), unmarried status (OR 2.38, 1.39-4.10), and “stress factor” (OR 1.48, 1.13-1.94). The “stress factor” was mostly influenced by stressors in dealing with patients/families and co-workers, concern about medical malpractice, and fatigue.Conclusions: Early-career EPs in Japan have a high prevalence of chronic insomnia and sleep-aid use. Long working hours and stress were associated with chronic insomnia, while male gender, unmarried status, and stress were associated with the use of sleep aids.

Published
2023

8. Association between reduced left ventricular ejection fraction and peritoneal dialysis related peritonitis: a single center retrospective cohort study in Japan

Author

Yamaguchi, Makoto, Obayashi, Takaaki, Kobayashi, Naoto, Izumi, Naoki, Nagai, Masaaki, Nobata, Hironobu, Asai, Akimasa, Kamiya, Keisuke, Sugiyama, Hirokazu, Kinashi, Hiroshi, Banno, Shogo, Ando, Masahiko, Imaizumi, Takahiro, Kubo, Yoko, Katsuno, Takayuki, Ishimoto, Takuji, and Ito, Yasuhiko

Published
2023
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14. Clinical parameter-based prediction of DNA methylation classification generates a prediction model of prognosis in patients with juvenile myelomonocytic leukemia

Author

Imaizumi, Takahiro, Meyer, Julia, Wakamatsu, Manabu, Kitazawa, Hironobu, Murakami, Norihiro, Okuno, Yusuke, Yoshida, Taro, Sajiki, Daichi, Hama, Asahito, Kojima, Seiji, Takahashi, Yoshiyuki, Loh, Mignon, Stieglitz, Elliot, and Muramatsu, Hideki

Subjects
Biological Sciences, Genetics, Pediatric, Pediatric Cancer, Rare Diseases, Cancer, Bayes Theorem, Child, Preschool, DNA Methylation, Humans, Leukemia, Myelomonocytic, Juvenile, Mutation, Prognosis
Abstract

Juvenile myelomonocytic leukemia (JMML) is a rare heterogeneous hematological malignancy of early childhood characterized by causative RAS pathway mutations. Classifying patients with JMML using global DNA methylation profiles is useful for risk stratification. We implemented machine learning algorithms (decision tree, support vector machine, and naïve Bayes) to produce a DNA methylation-based classification according to recent international consensus definitions using a well-characterized pooled cohort of patients with JMML (n = 128). DNA methylation was originally categorized into three subgroups: high methylation (HM), intermediate methylation (IM), and low methylation (LM), which is a trichotomized classification. We also dichotomized the subgroups as HM/IM and LM. The decision tree model showed high concordances with 450k-based methylation [82.3% (106/128) for the dichotomized and 83.6% (107/128) for the trichotomized subgroups, respectively]. With an independent cohort (n = 72), we confirmed that these models using both the dichotomized and trichotomized classifications were highly predictive of survival. Our study demonstrates that machine learning algorithms can generate clinical parameter-based models that predict the survival outcomes of patients with JMML and high accuracy. These models enabled us to rapidly and effectively identify candidates for augmented treatment following diagnosis.

Published
2022

20. Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts

Author

Ahn, Curie, Berger, Stefan P., Caskey, Fergus J., Cho, Min Hyun, Cho, Heeyeon, Dekker, Friedo W., Diwan, Vishal, Drechsler, Christiane, Eckardt, Kai-Uwe, Evans, Marie, Ferreiro, Alejandro, Floege, Jürgen, Gadola, Liliana, Haller, Hermann, Han, Kyung Hee, Healy, Helen G., Heerspink, Hiddo Lambers, Hemmelder, Marc, Hiemstra, Thomas, Hilbrands, Luuk, Kim, Seong Heon, Klyprayong, Pinkaew, Köttgen, Anna, Kronenberg, Florian, Lamadrid, Veronica, Lee, Joo Hoo, Mark, Patrick, Matheson, Matt, Mi, Eun, Noppakun, Kajohnsak, Oefner, Peter, Panaput, Thanachai, Park, Young Seo, Prokosch, Hans-Ulrich, Reis, André, Rios, Pablo, Rosivall, Laszlo, Rotmans, Joris I., Sackeyfio, Alfred, Sangthawan, Pornpen, Schmid, Matthias, Shin, Jae Il, Silavarino, Ricardo, Sitter, Thomas, Sommerer, Claudia, Szymczak, Maciej, Torino, Claudia, Toth, Janos, van Ittersum, Frans J., Venuthurupalli, Sree Krishna, Verhaar, Marianne C., Wang, Zaimin, Wanner, Christoph, Wiecek, Andrzej, Wolf, Gunter, de Zeeuw, Dick, Zhang, Luxia, Zheng, Yuyan, Zhao, Ming-Hui, Zietse, Robert, Canney, Mark, Induruwage, Dilshani, Tang, Mila, Alencar de Pinho, Natalia, Er, Lee, Zhao, Yinshan, Djurdjev, Ognjenka, Ahn, Yo Han, Behnisch, Rouven, Calice-Silva, Viviane, Chesnaye, Nicholas C., de Borst, Martin H., Dember, Laura M., Dionne, Janis, Ebert, Natalie, Eder, Susanne, Fenton, Anthony, Fukagawa, Masafumi, Furth, Susan L., Hoy, Wendy E., Imaizumi, Takahiro, Jager, Kitty J., Jha, Vivekanand, Kang, Hee Gyung, Kitiyakara, Chagriya, Mayer, Gert, Oh, Kook-Hwan, Onu, Ugochi, Pecoits-Filho, Roberto, Reichel, Helmut, Richards, Anna, Schaefer, Franz, Schaeffner, Elke, Scheppach, Johannes B., Sola, Laura, Ulasi, Ifeoma, Wang, Jinwei, Yadav, Ashok K., Zhang, Jianzhen, Feldman, Harold I., Taal, Maarten W., Stengel, Bénédicte, and Levin, Adeera

Published
2023
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24. Excess risk of cardiovascular events in patients in the United States vs. Japan with chronic kidney disease is mediated mainly by left ventricular structure and function

Author

Appel, Lawrence J., Chen, Jing, Cohen, Debbie L., Lash, James P., Nelson, Robert G., Rao, Panduranga S., Rahman, Mahboob, Shah, Vallabh O., Unruh, Mark L., Imaizumi, Takahiro, Fujii, Naohiko, Hamano, Takayuki, Yang, Wei, Taguri, Masataka, Kansal, Mayank, Mehta, Rupal, Shafi, Tariq, Taliercio, Jonathan, Go, Alan, Rao, Panduranga, Hamm, L. Lee, Deo, Rajat, Maruyama, Shoichi, Fukagawa, Masafumi, and Feldman, Harold I.

Published
2023
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27. Association of calciprotein particles with serum phosphorus among patients undergoing conventional and extended-hours haemodialysis

Author

Nishibori, Nobuhiro, primary, Okazaki, Masaki, additional, Miura, Yutaka, additional, Hishida, Manabu, additional, Kurasawa, Shimon, additional, Imaizumi, Takahiro, additional, Kato, Noritoshi, additional, Kosugi, Tomoki, additional, Kuro-o, Makoto, additional, Kasuga, Hirotake, additional, Kaneda, Fumika, additional, and Maruyama, Shoichi, additional

Published
2024
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34. Association of GLIM-Defined Malnutrition in Kidney Dysfunction With Increased All-Cause Mortality from Infections in Hospitalized Older Adults: A Retrospective Cohort Study

Author

Yamaguchi, Makoto, primary, Sugiyama, Hirokazu, additional, Akimasa, Asai, additional, Kamiya, Keisuke, additional, Kitamura, Fumiya, additional, Kinashi, Hiroshi, additional, Katsuno, Takayuki, additional, Bannno, Shogo, additional, Ishimoto, Takuji, additional, Imaizumi, Takahiro, additional, Maeda, Keisuke, additional, Ishida, Yuria, additional, Mori, Naoharu, additional, and Ito, Yasuhiko, additional

Published
2023
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38. Predictive factors for the development of leukemia in patients with transient abnormal myelopoiesis and Down syndrome

Author

Yamato, Genki, Deguchi, Takao, Terui, Kiminori, Toki, Tsutomu, Watanabe, Tomoyuki, Imaizumi, Takahiro, Hama, Asahito, Iwamoto, Shotaro, Hasegawa, Daisuke, Ueda, Takahiro, Yokosuka, Tomoko, Tanaka, Shiro, Yanagisawa, Ryu, Koh, Katsuyoshi, Saito, Akiko M., Horibe, Keizo, Hayashi, Yasuhide, Adachi, Souichi, Mizutani, Shuki, Taga, Takashi, Ito, Etsuro, Watanabe, Kenichiro, and Muramatsu, Hideki

Published
2021
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40. Modification Effects of Albuminuria on the Association Between Kidney Function and Development of Anemia in Diabetes.

Author

Okada, Akira, Yamaguchi, Satoko, Imaizumi, Takahiro, Oba, Koji, Kurakawa, Kayo Ikeda, Yamauchi, Toshimasa, Kadowaki, Takashi, and Nangaku, Masaomi

Abstract

Context Previous studies failed to adjust for estimated glomerular filtration rate (eGFR) in evaluating the association between albuminuria and anemia development, and we aimed to investigate whether albuminuria independently affects anemia development. Methods We conducted a retrospective cohort study and retrospectively identified adults with diabetes from a Japanese nationwide clinical database (JMDC, Tokyo, Japan). To assess the modification effects of albuminuria on the association between eGFR and anemia development, we estimated prevalence of anemia, defined as hemoglobin < 13 g/dL in men and < 12 g/dL in women, using a modified Poisson regression and marginal standardization form of predictive margins, stratified by albuminuria severity after adjusting for eGFR. Hence, we revealed at which eGFR level this modification effect appeared and the extent to which this modification effect increased the prevalence of anemia. Results We identified 327 999 data points from 48 056 individuals [normoalbuminuria: 186 472 (56.9%), microalbuminuria: 107 170 (32.7%), and macroalbuminuria: 34 357 (10.5%)]. As eGFR declined, anemia prevalence increased. Albuminuria severity modified this association induced by decreased eGFR among individuals with eGFR <30 mL/min/1.73 m2 after adjusting for multivariable factors, including age, sex, comorbidities, and medication use. Compared with the normoalbuminuric group, the macroalbuminuric group had a 5% to 20% higher anemia prevalence among individuals with eGFR of <30 mL/min/1.73 m2. Conclusion We revealed that the severity of albuminuria modified the association between eGFR and anemia development among individuals with eGFR <30 mL/min/1.73 m2, highlighting the modification effect of albuminuria on the association between kidney function and anemia development in diabetes. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Fibcare® shows correlation with fibrinogen levels by the Clauss method during cardiopulmonary bypass

Author

Yamada, Akihiro, Tamura, Takahiro, Imaizumi, Takahiro, Kubo, Yoko, and Nishiwaki, Kimitoshi

Subjects
Fibcare, platelet mapping, thromboelastography, fibrinogen, cardiopulmonary bypass
Abstract

Central laboratory measurements are time consuming, while rapid fibrinogen level measurements within the operating room improve transfusion strategies. We aimed to clarify the correlation between fibrinogen concentrations (measured using Fibcare® and the Clauss fibrinogen assay in a central laboratory) during cardiovascular surgery with cardiopulmonary bypass. Data of patients whose Fibcare, traditional laboratory-based testing, and thromboelastographic results were measured using the same blood sample during cardiopulmonary bypass from February 2021 to January 2022 were retrospectively examined. We analyzed correlation in categories of body temperature during cardiopulmonary bypass: total cases, mild hypothermia (28–34°C), and moderate or severe hypothermia (, This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Published
2023

47. Capacity for the management of kidney failure in the International Society of Nephrology North and East Asia region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)

Author

Wing-Shing Fung, Winston, Park, Hyeong Cheon, Hirakawa, Yosuke, Arruebo, Silvia, Bello, Aminu K., Caskey, Fergus J., Damster, Sandrine, Donner, Jo-Ann, Jha, Vivekanand, Johnson, David W., Levin, Adeera, Malik, Charu, Nangaku, Masaomi, Okpechi, Ikechi G., Tonelli, Marcello, Ueda, Seiji, Ye, Feng, Suzuki, Yusuke, Wang, Angela Yee-Moon, Amouzegar, Atefeh, Cai, Guangyan, Chang, Jer-Ming, Chen, Hung-Chun, Cheng, Yuk Lun, Cho, Yeoungjee, Davids, M. Razeen, Davison, Sara N., Diongole, Hassane M., Divyaveer, Smita, Doi, Kent, Ekrikpo, Udeme E., Ethier, Isabelle, Fukami, Kei, Ghimire, Anukul, Houston, Ghenette, Htay, Htay, Ibrahim, Kwaifa Salihu, Imaizumi, Takahiro, Irish, Georgina, Jindal, Kailash, Kashihara, Naoki, Kelly, Dearbhla M., Lalji, Rowena, Liu, Bi-Cheng, Maruyama, Shoichi, Nalado, Aisha M., Neuen, Brendon L., Nie, Jing, Nishiyama, Akira, Olanrewaju, Timothy O., Osman, Mohamed A., Petrova, Anna, Riaz, Parnian, Saad, Syed, Sakajiki, Aminu Muhammad, See, Emily, Sozio, Stephen M., Tang, Sydney C.W., Tiv, Sophanny, Tungsanga, Somkanya, Viecelli, Andrea, Wainstein, Marina, Yanagita, Motoko, Yang, Chih-Wei, Yang, Jihyun, Yeung, Emily K., Yu, Xueqing, Zaidi, Deenaz, Zhang, Hong, and Zhou, Lili

Abstract

Globally, there remain significant disparities in the capacity and quality of kidney care, as evidenced by the third edition of the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA). In the ISN North and East Asia region, the chronic kidney disease (CKD) burden varied widely; Taiwan had the heaviest burden of treated kidney failure (3679 per million population [pmp]) followed by Japan and South Korea. Except in Hong Kong, hemodialysis (HD) was the main dialysis modality for all other countries in the region and was much higher than the global median prevalence. Kidney transplantation services were generally available in the region, but the prevalence was much lower than that of dialysis. Most countries had public funding for kidney replacement therapy (KRT). The median prevalence of nephrologists was 28.7 pmp, higher than that of any other ISN region, with variation across countries. Home HD was available in only 17% of the countries, whereas conservative kidney management was available in 50%. All countries had official registries for dialysis and transplantation; however, only China and Japan had CKD registries. Advocacy groups for CKD, kidney failure, and KRT were uncommon throughout the region. Overall, all countries in the region had capacity for KRT, albeit with some shortages in their kidney care workforce. These data are useful for stakeholders to address gaps in kidney care and to reduce workforce shortages through increased use of multidisciplinary teams and telemedicine, policy changes to promote prevention and treatment of kidney failure, and increased advocacy for kidney disease in the region.

Published
2024
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48. Association between serum iron markers, iron supplementation and cardiovascular morbidity in pre-dialysis chronic kidney disease.

Author

Hasegawa, Takeshi, Imaizumi, Takahiro, Hamano, Takayuki, Murotani, Kenta, Fujii, Naohiko, Komaba, Hirotaka, Ando, Masahiko, Maruyama, Shoichi, Nangaku, Masaomi, Nitta, Kosaku, Hirakata, Hideki, Isaka, Yoshitaka, Wada, Takashi, and Fukagawa, Masafumi

Subjects
*IRON supplements, *IRON in the body, *CHRONIC kidney failure, *BIOMARKERS, *CARDIOVASCULAR diseases, *CONGESTIVE heart failure
Abstract

Background The optimal range of serum iron markers and usefulness of iron supplementation are uncertain in patients with pre-dialysis chronic kidney disease (CKD). We investigated the association between serum iron indices and risk of cardiovascular disease (CVD) events and the effectiveness of iron supplementation using Chronic Kidney Disease Japan Cohort data. Methods We included 1416 patients ages 20–75 years with pre-dialysis CKD. The tested exposures were serum transferrin saturation and serum ferritin levels and the outcome measures were any cardiovascular event. Fine–Gray subdistribution hazard models were used to examine the association between serum iron indices and time to events. The multivariable fractional polynomial interaction approach was used to evaluate whether serum iron indices were effect modifiers of the association between iron supplementation and cardiovascular events. Results The overall incidence rate of CVD events for a median of 4.12 years was 26.7 events/1000 person-years. Patients with serum transferrin saturation <20% demonstrated an increased risk of CVD [subdistribution hazard ratio (HR) 2.13] and congestive heart failure (subdistribution HR 2.42). The magnitude of reduction in CVD risk with iron supplementation was greater in patients with lower transferrin saturations (P  = .042). Conclusions Maintaining transferrin saturation >20% and adequate iron supplementation may effectively reduce the risk of CVD events in patients with pre-dialysis CKD. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts

Author

Canney, Mark, primary, Induruwage, Dilshani, additional, Tang, Mila, additional, Alencar de Pinho, Natalia, additional, Er, Lee, additional, Zhao, Yinshan, additional, Djurdjev, Ognjenka, additional, Ahn, Yo Han, additional, Behnisch, Rouven, additional, Calice-Silva, Viviane, additional, Chesnaye, Nicholas C., additional, de Borst, Martin H., additional, Dember, Laura M., additional, Dionne, Janis, additional, Ebert, Natalie, additional, Eder, Susanne, additional, Fenton, Anthony, additional, Fukagawa, Masafumi, additional, Furth, Susan L., additional, Hoy, Wendy E., additional, Imaizumi, Takahiro, additional, Jager, Kitty J., additional, Jha, Vivekanand, additional, Kang, Hee Gyung, additional, Kitiyakara, Chagriya, additional, Mayer, Gert, additional, Oh, Kook-Hwan, additional, Onu, Ugochi, additional, Pecoits-Filho, Roberto, additional, Reichel, Helmut, additional, Richards, Anna, additional, Schaefer, Franz, additional, Schaeffner, Elke, additional, Scheppach, Johannes B., additional, Sola, Laura, additional, Ulasi, Ifeoma, additional, Wang, Jinwei, additional, Yadav, Ashok K., additional, Zhang, Jianzhen, additional, Feldman, Harold I., additional, Taal, Maarten W., additional, Stengel, Bénédicte, additional, Levin, Adeera, additional, Ahn, Curie, additional, Berger, Stefan P., additional, Caskey, Fergus J., additional, Cho, Min Hyun, additional, Cho, Heeyeon, additional, Dekker, Friedo W., additional, Diwan, Vishal, additional, Drechsler, Christiane, additional, Eckardt, Kai-Uwe, additional, Evans, Marie, additional, Ferreiro, Alejandro, additional, Floege, Jürgen, additional, Gadola, Liliana, additional, Haller, Hermann, additional, Han, Kyung Hee, additional, Healy, Helen G., additional, Heerspink, Hiddo Lambers, additional, Hemmelder, Marc, additional, Hiemstra, Thomas, additional, Hilbrands, Luuk, additional, Kim, Seong Heon, additional, Klyprayong, Pinkaew, additional, Köttgen, Anna, additional, Kronenberg, Florian, additional, Lamadrid, Veronica, additional, Lee, Joo Hoo, additional, Mark, Patrick, additional, Matheson, Matt, additional, Mi, Eun, additional, Noppakun, Kajohnsak, additional, Oefner, Peter, additional, Panaput, Thanachai, additional, Park, Young Seo, additional, Prokosch, Hans-Ulrich, additional, Reis, André, additional, Rios, Pablo, additional, Rosivall, Laszlo, additional, Rotmans, Joris I., additional, Sackeyfio, Alfred, additional, Sangthawan, Pornpen, additional, Schmid, Matthias, additional, Shin, Jae Il, additional, Silavarino, Ricardo, additional, Sitter, Thomas, additional, Sommerer, Claudia, additional, Szymczak, Maciej, additional, Torino, Claudia, additional, Toth, Janos, additional, van Ittersum, Frans J., additional, Venuthurupalli, Sree Krishna, additional, Verhaar, Marianne C., additional, Wang, Zaimin, additional, Wanner, Christoph, additional, Wiecek, Andrzej, additional, Wolf, Gunter, additional, de Zeeuw, Dick, additional, Zhang, Luxia, additional, Zheng, Yuyan, additional, Zhao, Ming-Hui, additional, and Zietse, Robert, additional

Published
2023
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