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Tumour immunology has travelled a long and bumpy road. Gerard Evan examines an uneven treatment of it. Tumour immunology has travelled a long and bumpy road. Gerard Evan examines an uneven treatment of it., Author(s): Gerard Evan Author Affiliations: The return of cancer's magic bullet A build-up of white blood cells (shown in purple) in chronic lymphocytic leukaemia. [see PDF for image] Credit: Steve [...]

Background/Objectives: Glutathione (GSH) is the most abundant endogenous antioxidant and a critical regulator of oxidative stress. Maintenance of optimal tissues for GSH levels may be an important strategy for the prevention of oxidative stress-related diseases. We investigated if oral administration of liposomal GSH is effective at enhancing GSH levels in vivo. Subjects/Methods: A 1-month pilot clinical study of oral liposomal GSH administration at two doses (500 and 1000 mg of GSH per day) was conducted in healthy adults. GSH levels in whole blood, erythrocytes, plasma and peripheral blood mononuclear cells (PBMCs) were assessed in 12 subjects at the baseline and after 1, 2 and 4 weeks of GSH administration. Results: GSH levels were elevated after 1 week with maximum increases of 40% in whole blood, 25% in erythrocytes, 28% in plasma and 100% in PBMCs occurring after 2 weeks (P [less than] 0.05). GSH increases were accompanied by reductions in oxidative stress biomarkers, including decreases of 35% in plasma 8-isoprostane and 20% in oxidized:reduced GSH ratios (P [less than] 0.05). Enhancements in immune function markers were observed with liposomal GSH administration including Natural killer (NK) cell cytotoxicity, which was elevated by up to 400% by 2 weeks (P [less than] 0.05), and lymphocyte proliferation, which was elevated by up to 60% after 2 weeks (P [less than] 0.05). Overall, there were no differences observed between dose groups, but statistical power was limited due to the small sample size in this study. Conclusions: Collectively, these preliminary findings support the effectiveness of daily liposomal GSH administration at elevating stores of GSH and impacting the immune function and levels of oxidative stress. European Journal of Clinical Nutrition (2018) 72, 105-111; doi: 10.1038/ejcn.2017.132; published online 30 August 2017, Author(s): R Sinha [1]; I Sinha [1]; A Calcagnotto [2]; N Trushin [2]; J S Haley [3]; T D Schell [3]; J P Richie, Jr [2] Introduction Glutathione (GSH) is [...]