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1. Human antibody polyreactivity is governed primarily by the heavy-chain complementarity-determining regions.

2. An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms.

3. Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining.

4. Antibody-SGM, a Score-Based Generative Model for Antibody Heavy-Chain Design.

5. Development of novel humanized VHH synthetic libraries based on physicochemical analyses.

6. High-throughput quantitative assessments of the chemical complementarity of celiac disease-related IGH CDR3s and a gliadin epitope.

7. SARS-CoV-2 JN.1 variant evasion of IGHV3-53/3-66 B cell germlines.

8. Characterization of neutralizing chimeric heavy-chain antibodies against tetanus toxin.

9. Neutralizing chimeric heavy-chain antibody targeting the L-HN domain of Clostridium botulinum neurotoxin type F.

10. A single-domain antibody library based on a stability-engineered human VH3 scaffold.

11. Glycan-Reactive Innate-like B Cells and Developmental Checkpoints.

12. Generation of nanobodies from transgenic 'LamaMice' lacking an endogenous immunoglobulin repertoire.

13. Characterization of a novel format scFv×VHH single-chain biparatopic antibody against metal binding protein MtsA.

14. Chickens with a Truncated Light Chain Transgene Express Single-Domain H Chain-Only Antibodies.

15. Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody.

16. Anti-Idiotypic VHHs and VHH-CAR-T Cells to Tackle Multiple Myeloma: Different Applications Call for Different Antigen-Binding Moieties.

17. Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates.

18. Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor.

19. For antibody sequence generative modeling, mixture models may be all you need.

20. Isolation and characterization of Hc-targeting chimeric heavy chain antibodies neutralizing botulinum neurotoxin type B.

21. Discovery of potent allosteric antibodies inhibiting EGFR.

22. Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions.

23. Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses.

24. V H -Based Mini Q-Body: A Novel Quench-Based Immunosensor.

25. Vaccination induces HIV broadly neutralizing antibody precursors in humans.

26. Functional antibodies exhibit light chain coherence.

27. B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccination.

28. Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization.

29. Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis.

30. Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients.

31. Heavy chain-only antibody genes in fish evolved to generate unique CDR3 repertoire.

32. A Recombinant Ig Fragment (IgCw-γεκ) Comprising the Cγ 1 -Cε 2-4 and C κ Domains Is an Alternative Reagent to Human IgE.

33. The Splenic Marginal Zone in Children Is Characterized by a Subpopulation of CD27-Negative, Lowly IGHV-Mutated B Cells.

34. Easily Established and Multifunctional Synthetic Nanobody Libraries as Research Tools.

35. SAbDab in the age of biotherapeutics: updates including SAbDab-nano, the nanobody structure tracker.

36. Observed Antibody Space: A diverse database of cleaned, annotated, and translated unpaired and paired antibody sequences.

37. Reshaping the murine immunoglobulin heavy chain repertoire with bovine DH genes.

38. Isolation and Characterization of Human Monoclonal Antibodies to Pneumococcal Capsular Polysaccharide 3.

39. Age-related changes in the TRB and IGH repertoires in healthy adult males and females.

40. IgG-like bispecific antibody platforms with built-in purification-facilitating elements.

41. Maternal and Infant Immune Repertoire Sequencing Analysis Identifies Distinct Ig and TCR Development in Term and Preterm Infants.

42. UnAIDed Class Switching in Activated B-Cells Reveals Intrinsic Features of a Self-Cleaving IgH Locus.

43. Cancer-Cell-Derived IgG and Its Potential Role in Tumor Development.

44. Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses.

45. Intrathymic differentiation of natural antibody-producing plasma cells in human neonates.

46. Normal IgH Repertoire Diversity in an Infant with ADA Deficiency After Gene Therapy.

47. Regulatory Approved Monoclonal Antibodies Contain Framework Mutations Predicted From Human Antibody Repertoires.

48. Protocol for constructing large size human antibody heavy chain variable domain (V H ) library and selection of SARS-CoV-2 neutralizing antibody domains.

49. Long-Range Control of Class Switch Recombination by Transcriptional Regulatory Elements.

50. Mouse CD38-Specific Heavy Chain Antibodies Inhibit CD38 GDPR-Cyclase Activity and Mediate Cytotoxicity Against Tumor Cells.

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