1. 8,15-Epoxylabdane and norlabdane diterpenoids from Eragrostis viscosa
- Author
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Célia Martins, Dina I.M.D. de Mendonça, Inês J.S. Cordeiro, Carlos Diakanamwa, Aldenir Feitosa dos Santos, Antônio Euzébio Goulart Santana, N’Soki N. Sebastião, Jorge F. Gaspar, and José Rueff
- Subjects
Models, Molecular ,Magnetic Resonance Spectroscopy ,biology ,Snails ,Biological activity ,Plant Science ,General Medicine ,Eragrostis ,Horticulture ,Crystallography, X-Ray ,biology.organism_classification ,Biochemistry ,Terpenoid ,Hexane ,chemistry.chemical_compound ,chemistry ,Molluscicide ,Botany ,Animals ,Biomphalaria glabrata ,Diterpenes ,Diterpene ,Medicinal plants ,Molecular Biology - Abstract
Four labdanes with a 8alpha,15-epoxy ring (8alpha,15-epoxylabdan-16beta-oic acid; 8alpha,15-epoxy-16-norlabdan-13-one; 8alpha,15-epoxy-16-norlabdane; and 16-acetoxy-8alpha,15-epoxylabdane) and the known compound ambreinolide were isolated from the hexane extract of the aerial parts of the grass Eragrostis viscosa. The structures of all compounds were established based on spectroscopic data and the X-ray analysis of 8alpha,15-epoxy-16-norlabdan-13-one. The hexane extract presented moderate activity against the snail Biomphalaria glabrata. 8alpha,15-Epoxylabdan-16beta-oic acid showed no mutagenic activity for doses up to 1000 microg/plate and no significant clastogenic activity for doses up to 100 microg/ml.
- Published
- 2010
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