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19 results on '"Inagaki, Sachi"'

3. A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila

Author

Saito, Kuniaki, Inagaki, Sachi, Mituyama, Toutai, Kawamura, Yoshinori, Ono, Yukiteru, Sakota, Eri, Kotani, Hazuki, Asai, Kiyoshi, Siomi, Haruhiko, and Siomi, Mikiko C.

Subjects
Retrotransposons -- Physiological aspects -- Genetic aspects -- Research, Gene silencing -- Research -- Genetic aspects -- Physiological aspects, Messenger RNA -- Physiological aspects -- Genetic aspects -- Research, Somatic cells -- Genetic aspects -- Research -- Physiological aspects, Genetic regulation -- Research -- Genetic aspects -- Physiological aspects, Drosophila -- Genetic aspects -- Research -- Physiological aspects, Germ cells -- Genetic aspects -- Physiological aspects -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

PIWI-interacting RNAs (piRNAs) silence retrotransposons in Drosophila germ lines by associating with the PIWI proteins Argonaute 3 (AGO3), Aubergine (Aub) and Piwi (1,2). piRNAs in Drosophila are produced from intergenic repetitive genes and piRNA clusters by two systems: the primary processing pathway and the amplification loop (1-7). The amplification loop occurs in a Dicer-independent, PIWI-Slicer-dependent manner (3,4,8). However, primary piRNA processing remains elusive. Here we analysed piRNA processing in a Drosophila ovarian somatic cell line where Piwi, but not Aub or AGO3, is expressed; thus, only the primary piRNAs exist. In addition to flamenco, a Piwi-specificpiRNA cluster (3), traffic jam (tj) (9), a large Maf gene, was determined as a new piRNA cluster. piRNAs arising from tj correspond to the untranslated regions of tj messenger RNA and are sense-oriented. piRNA loading on to Piwi may occur in the cytoplasm. Zucchini (10), a gene encoding a putative cytoplasmic nuclease, is required for tj-derived piRNA production. In tj and piwi mutant ovaries, somatic cells fail to intermingle with germ cells and Fasciclin III is overexpressed. Loss of tj abolishes Piwi expression in gonadal somatic cells. Thus, in gonadal somatic cells, tj gives rise simultaneously to two different molecules: the TJ protein, which activates Piwi expression, and piRNAs, which define the Piwi targets for silencing., Genetic studies have shown that piwi and aub are essential in germ-line stem-cell self-renewal and pole-cell formation, respectively (11,12). Mutations introduced into piwi and aub cause de-repression of retro-transposons and [...]

Published
2009

4. Osirisgene family defines the cuticle nanopatterns of Drosophila

Author

Sun, Zhengkuan, Inagaki, Sachi, Miyoshi, Keita, Saito, Kuniaki, and Hayashi, Shigeo

Abstract

Nanostructures of pores and protrusions in the insect cuticle modify molecular permeability and surface wetting and help insects sense various environmental cues. However, the cellular mechanisms that modify cuticle nanostructures are poorly understood. Here, we elucidate how insect-specific Osirisfamily genes are expressed in various cuticle-secreting cells in the Drosophilahead during the early stages of cuticle secretion and cover nearly the entire surface of the head epidermis. Furthermore, we demonstrate how each sense organ cell with various cuticular nanostructures expressed a unique combination of Osirisgenes. Osirisgene mutations cause various cuticle defects in the corneal nipples and pores of the chemosensory sensilla. Thus, our study emphasizes on the importance of Osirisgenes for elucidating cuticle nanopatterning in insects.

Published
2024
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7. Nanopore Formation in the Cuticle of an Insect Olfactory Sensillum

Author

Ando, Toshiya, primary, Sekine, Sayaka, additional, Inagaki, Sachi, additional, Misaki, Kazuyo, additional, Badel, Laurent, additional, Moriya, Hiroyuki, additional, Sami, Mustafa M., additional, Itakura, Yuki, additional, Chihara, Takahiro, additional, Kazama, Hokto, additional, Yonemura, Shigenobu, additional, and Hayashi, Shigeo, additional

Published
2019
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10. Nanopore formation in the cuticle of an insect olfactory sensillum

Author

Ando, Toshiya, primary, Sekine, Sayaka, additional, Inagaki, Sachi, additional, Misaki, Kazuyo, additional, Badel, Laurent, additional, Moriya, Hiroyuki, additional, Sami, Mustafa M., additional, Itakura, Yuki, additional, Chihara, Takahiro, additional, Kazama, Hokto, additional, Yonemura, Shigenobu, additional, and Hayashi, Shigeo, additional

Published
2018
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12. Pri peptides are mediators of ecdysone for the temporal control of development

Author

Chanut-Delalande, Hélène, primary, Hashimoto, Yoshiko, additional, Pelissier-Monier, Anne, additional, Spokony, Rebecca, additional, Dib, Azza, additional, Kondo, Takefumi, additional, Bohère, Jérôme, additional, Niimi, Kaori, additional, Latapie, Yvan, additional, Inagaki, Sachi, additional, Dubois, Laurence, additional, Valenti, Philippe, additional, Polesello, Cédric, additional, Kobayashi, Satoru, additional, Moussian, Bernard, additional, White, Kevin P., additional, Plaza, Serge, additional, Kageyama, Yuji, additional, and Payre, François, additional

Published
2014
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18. [Coding vs. non-coding: lessons from Drosophila].

Author

Kageyama Y and Inagaki S

Subjects
Animals, Gene Expression Profiling, Molecular Weight, Peptides genetics, Proteins genetics, Transcription, Genetic genetics, Drosophila genetics, RNA, Messenger, RNA, Untranslated
Published
2008

19. [Physiological roles of non-coding RNAs: lessons from model organisms].

Author

Kageyama Y and Inagaki S

Subjects
Animals, Cells, Cultured, Dendrites genetics, Dendrites physiology, Gene Expression Regulation, Developmental, Homeodomain Proteins genetics, Humans, Models, Genetic, RNA, Long Noncoding, MicroRNAs physiology, RNA, Untranslated physiology
Published
2006

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