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6. Early Cryoablation After First Diagnosis of Atrial Fibrillation Reduces Arrhythmia Recurrence in Heart Failure Patients

Author

Ando, Monami, Yanagisawa, Satoshi, Suzuki, Hirohiko, Yoshida, Yukihiko, Kanzaki, Yasunori, Morishima, Itsuro, Ishikawa, Shinji, Kamikubo, Yosuke, Okumura, Satoshi, Kato, Hiroyuki, Mizutani, Yoshiaki, Murase, Yosuke, Nakasuka, Kosuke, Warita, Shunichiro, Sekimoto, Satoru, Takemoto, Yoshio, Takasugi, Nobuhiro, Ohguchi, Shiou, Senga, Michiharu, Yokoi, Kenichiro, Watanabe, Ryo, Ogura, Yasuhiro, Shibata, Rei, Inden, Yasuya, and Murohara, Toyoaki

Published
2024
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9. Initial multicenter clinical experience with the first-generation endoscopic guided laser balloon in Japan

Author

Goya, Masahiko, Hirao, Kenzo, Aonuma, Kazutaka, Nogami, Akihiko, Yamane, Teiichi, Yamauchi, Yasuteru, Okishige, Kaoru, Yotsukura, Akihiko, Kimura, Masaomi, Naito, Shigeto, Kato, Ritsushi, Nitta, Junichi, Inaba, Osamu, Satomi, Kazuhiro, Morita, Norishige, Kobayashi, Yoshinori, Inden, Yasuya, Yoshida, Yukihiko, Kakita, Ken, Kobori, Atsushi, Kusano, Kengo, Inoue, Koichi, Masuda, Masaharu, Hiroshima, Kenichi, Koyama, Junjiroh, Kumagai, Koichiro, and Okumura, Ken

Published
2023
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12. Triggers of Ventricular Fibrillation in Patients With Inferolateral J-Wave Syndrome

Author

Komatsu, Yuki, Nogami, Akihiko, Hocini, Mélèze, Morita, Hiroshi, Sato, Nobuyuki, Marijon, Eloi, Arentz, Thomas, Yli-Mäyry, Sinikka, Onishi, Yoshimi, Kowase, Shinya, Duchateau, Josselin, Benali, Karim, Takase, Tetsuro, Hosaka, Yukio, Takei, Asumi, Nakajima, Ikutaro, Kawamura, Mitsuharu, Inden, Yasuya, Ieda, Masaki, Aonuma, Kazutaka, and Haïssaguerre, Michel

Published
2024
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13. Association Between Catheter Ablation for Nonparoxysmal Atrial Fibrillation and Functional Mitral Regurgitation in Patients With Heart Failure With Preserved Ejection Fraction

Author

Yamauchi, Ryota, Morishima, Itsuro, Okumura, Kenji, Kanzaki, Yasunori, Morita, Yasuhiro, Watanabe, Naoki, Furui, Koichi, Yoshioka, Naoki, Shibata, Naoki, Miyazawa, Hiroyuki, Shimojo, Kazuki, Imaoka, Takuro, Sakamoto, Gaku, Goto, Hiroki, Ohi, Takuma, Yanagisawa, Satoshi, Inden, Yasuya, and Murohara, Toyoaki

Published
2023
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14. The ridge line of left pulmonary vein isolation from left atrial appendage can subsequently increase the completion rate of the mitral isthmus block line

Author

Hori, Hitomi, Kaneko, Shinji, Fujita, Masaya, Nagai, Shin, Ito, Ryota, Shirai, Yoshinori, Adachi, Kentaro, Suzuki, Noriyuki, Suzuki, Junya, Kondo, Kiyota, Yamauchi, Ryota, Haga, Tomoaki, Tatami, Yosuke, Ohashi, Taiki, Kubota, Ryuji, Shinoda, Masanori, Tanaka, Akihito, Inden, Yasuya, and Murohara, Toyoaki

Published
2023
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17. Cryoballoon ablation for atrial fibrillation without the use of a contrast medium: a combination of the intracardiac echocardiography and pressure wave monitoring guided approach

Author

Makino, Yuichiro, Mizutani, Yoshiaki, Yamashita, Daiki, Yonekawa, Jun, Satake, Akinori, Kurobe, Masanari, Hiramatsu, Takatsugu, Ichimiya, Hitoshi, Uchida, Yasuhiro, Watanabe, Junji, Kanashiro, Masaaki, Ichimiya, Satoshi, Yanagisawa, Satoshi, Inden, Yasuya, and Murohara, Toyoaki

Published
2022
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22. Identification of regions maintaining atrial fibrillation through cycle length and cycle length gradient mapping.

Author

Shimojo, Masafumi, Inden, Yasuya, Yanagisawa, Satoshi, Yamauchi, Ryota, Hiramatsu, Kei, Iwawaki, Tomoya, Tachi, Masaya, Kondo, Shun, Goto, Takayuki, Tsuji, Yukiomi, and Murohara, Toyoaki

Subjects
ARRHYTHMIA diagnosis, ARM physiology, CROSS-sectional method, PEARSON correlation (Statistics), PROFESSIONAL practice, HEART atrium, T-test (Statistics), FISHER exact test, TREATMENT effectiveness, MAGNETIC resonance imaging, DESCRIPTIVE statistics, MANN Whitney U Test, RADIAL bone, ATRIAL fibrillation, CATHETER ablation, COMPARATIVE studies, DATA analysis software, RELIABILITY (Personality trait), ELECTROPHYSIOLOGY, DISEASE progression, NONPARAMETRIC statistics, REGRESSION analysis
Abstract

Background: Visualizing the specific regions where atrial fibrillation (AF) is maintained is crucial for effective treatment, but it remains challenging in clinical practice. We aimed to address this challenge by developing a mapping approach focused on the cycle length (CL) and its gradient (CL‐gradient). Methods: In 105 patients undergoing initial ablation for persistent AF, pre‐ablation CARTOFINDER data were utilized to create maps based on three indicators: (1) CL, the atrial frequency during AF calculated using CARTOFINDER; (2) Short CL, encompassing CLs within 5 ms of the minimum CL; and (3) CL‐gradient, the CL range within a 6 mm radius. We evaluated the association between the AF termination through ablation and the measured values and patterns in each map. Results: AF termination occurred in 17 patients. The AF termination group exhibited the significant large maximum CL‐gradient (48.8 ms [interquartile range, 38.6–66.3], p <.001) and the short distance between the minimum CL site and the maximum CL‐gradient site (15.8 mm, [interquartile range, 6.0–23.2], p =.029). Of the 17 AF termination cases, 13 exhibited a CL distribution pattern characterized by a steep CL‐gradient near the minimum CL site (SG‐MCL), defined as the distance of less than 23.2 mm and the maximum CL‐gradient greater than 33.1 ms. In these AF termination cases, SG‐MCL was also correlated with the ablation area. Conclusions: The minimum CL area accompanied by significant CL gradients in the immediate vicinity may play a crucial role in sustaining AF. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Synthesized V7 QRS Amplitude and Oversensing Episodes in Patients With Subcutaneous Implantable Cardioverter‐Defibrillators.

Author

Okajima, Takashi, Ishikawa, Shinji, Yanagisawa, Satoshi, Okamoto, Takayuki, Uemura, Yusuke, Takemoto, Kenji, Inden, Yasuya, Murohara, Toyoaki, and Watarai, Masato

Subjects
ARRHYTHMIA treatment, ELECTRIC countershock, BRUGADA syndrome, LOGISTIC regression analysis, RETROSPECTIVE studies, DESCRIPTIVE statistics, ELECTROCARDIOGRAPHY, LONGITUDINAL method, ODDS ratio, IMPLANTABLE cardioverter-defibrillators, MEDICAL records, ACQUISITION of data, STATISTICS, MEDICAL equipment reliability, COMPARATIVE studies, CONFIDENCE intervals, ELECTROPHYSIOLOGY, DISEASE incidence, SENSITIVITY & specificity (Statistics)
Abstract

Background: Patients with subcutaneous implantable cardioverter‐defibrillators (S‐ICDs) experience an oversensing episode (OS) more frequently than those with transvenous ICDs. However, no established electrocardiography (ECG) parameters can accurately detect an OS. This study aimed to evaluate the incidence of an OS in real‐world clinical practice and the association of synthesized 18‐lead ECG (syn18‐ECG) parameters with an OS. Methods: We retrospectively included 21 consecutive patients who underwent S‐ICD implantation and collected syn18‐ECG parameters. We placed the generator in a deep posterior position and defined an OS as an inappropriate charging episode caused by cardiac or noncardiac signals. A SMART pass filter and two tachyarrhythmia zones were programed. Results: The most frequent underlying heart disease was Brugada/J wave syndrome (n = 7). During a median follow‐up period of 1188 days, an OS was observed in six patients (28.6%). The QRS amplitude in synthesized V7 lead (synV7) was significantly lower in the OS group than in the non‐OS group (0.59 ± 0.17 vs. 0.91 ± 0.35 mV, p = 0.019). The optimal cutoff value of synV7 QRS amplitude was 0.61 mV, with a sensitivity of 80.0% and a specificity of 83.7% for predicting an OS. Univariate logistic analysis showed that a synV7 QRS amplitude of <0.61 mV was only associated with an OS (odd ratio, 20.0; 95% confidence interval, 1.66–241.72; p = 0.018). Conclusions: In patients with S‐ICDs, an OS was not a rare complication during long‐term follow‐up. A low synV7 QRS amplitude was associated with a high OS incidence. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Comparison of the empirical linear ablation and low voltage area-guided ablation in addition to pulmonary vein isolation in patients with persistent atrial fibrillation: a propensity score-matched analysis

Author

Suzuki, Noriyuki, Kaneko, Shinji, Fujita, Masaya, Shinoda, Masanori, Kubota, Ryuji, Ohashi, Taiki, Tatami, Yosuke, Suzuki, Junya, Hori, Hitomi, Adachi, Kentaro, Ito, Ryota, Shirai, Yoshinori, Yanagisawa, Satoshi, Inden, Yasuya, and Murohara, Toyoaki

Published
2022
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28. Evaluation of microembolic signals on carotid ultrasound during pulmonary vein isolation with high‐power short‐duration and cryoballoon ablations: When and where do bubble and solid emboli arise?

Author

Mizutani, Yoshiaki, primary, Yanagisawa, Satoshi, additional, Ichikawa, Mizuki, additional, Nishio, Keisuke, additional, Sakai, Hiroya, additional, Nonokawa, Daishi, additional, Makino, Yuichiro, additional, Suzuki, Hitomi, additional, Ichimiya, Hitoshi, additional, Uchida, Yasuhiro, additional, Watanabe, Junji, additional, Kanashiro, Masaaki, additional, Inden, Yasuya, additional, and Murohara, Toyoaki, additional

Published
2024
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33. Reversible complete left bundle branch block and a wide QRS complex following administration of sodium-glucose cotransporter-2 inhibitor and volume reduction in a patient with systolic heart failure: a case report.

Author

Takenaka, Masaki, Yanagisawa, Satoshi, Yoshida, Yukihiko, Inden, Yasuya, and Murohara, Toyoaki

Subjects
BUNDLE-branch block, HEART failure, CARDIAC pacing, HEART failure patients, COMBINED modality therapy
Abstract

Background Guidelines recommend optimal medical therapy before cardiac resynchronization therapy (CRT) implantation. Herein, we report the potential effect of sodium-glucose cotransporter-2 inhibitors (SGLT2is) in improving the QRS duration and volume reduction in a patient with complete left bundle branch block (CLBBB) and reduced cardiac function. Case summary A 68-year-old man with a history of ischaemic cardiomyopathy and decreased cardiac function had exacerbation of heart failure (HF) at an outpatient clinic. His QRS duration increased remarkably with a CLBBB of 143 ms on an electrocardiogram, and left ventricular desynchrony was assessed by echocardiography, suggesting an indication of CRT implantation. Administration of an SGLT2i and multimodal treatment for HF stabilized his HF condition and improved the QRS duration and volume reduction thereafter. The CLBBB recovered to incomplete LBBB with a QRS duration of 112 ms on electrocardiography after 6 months. The patient has been stably followed up with continuous medications, including SGLT2i, without requiring CRT implantation or worsening of HF for 12 months. Discussion This case presents a unique scenario wherein electrical and mechanical reverse remodelling occurred in a patient with systolic HF and CLBBB, highlighting the potential benefits of SGLT2i in HF management. It may be important to carefully consider CRT indications when seeking other options to treat HF conditions and recognize an unusual phenomenon of reverse LBBB in clinical cases. [ABSTRACT FROM AUTHOR]

Published
2024
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34. A Novel Liver Fibrosis Marker FIB‐5 Index Predicted Response to Cardiac Resynchronization Therapy and Prognostic Outcomes in Patients With Heart Failure.

Author

Iwawaki, Tomoya, Inden, Yasuya, Yanagisawa, Satoshi, Goto, Takayuki, Kondo, Shun, Tachi, Masaya, Hiramatsu, Kei, Yamauchi, Ryota, Shimojo, Masafumi, Tsuji, Yukiomi, and Murohara, Toyoaki

Abstract

Background: The fibrosis‐5 (FIB‐5) index is a noninvasive marker for assessing the progression of liver fibrosis and predictor in patients with heart failure (HF). This study investigated the association between the FIB‐5 index and response to cardiac resynchronization therapy (CRT) and evaluated its predictive value for prognosis. Methods: In total, 203 patients who underwent CRT/CRT‐defibrillator (CRT‐D) implantation were retrospectively included. The FIB‐5 index was calculated using blood samples obtained before and after CRT/CRT‐D. Response to CRT was defined as a relative reduction in left ventricular end‐systolic volume of ≥15% 6 months after CRT/CRT‐D. We compared the prognosis after CRT/CRT‐D between the groups according to the FIB‐5 index. Results: One hundred and twenty‐three patients (61%) responded to CRT. The responder group demonstrated a significantly higher FIB‐5 index than the nonresponder group (−2.76 ± 3.85 vs. −4.67 ± 3.29, p < 0.001). Receiver‐operating characteristic analysis demonstrated that the area under the curve of the FIB‐5 index was 0.660 with a cutoff value of −4.00 for responders. In multivariate analysis, FIB‐5 index ≥ −4.00 was an independent predictor for CRT response (odds ratio: 3.665, p = 0.003), in addition to QRS duration ≥ 150 ms and echocardiographic dysynchrony. The FIB‐5 index increased significantly after 6 months in the responder group but not in the nonresponder group. The FIB‐5 index ≥ −4.00 group showed a significantly better prognosis for cardiac death, HF hospitalization, and composite endpoint than the FIB‐5 index < −4.00 group. Conclusion: The FIB‐5 index in addition to classical predictors may be a useful marker for predicting response to CRT. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Comparison of novel intrinsic versus conventional antitachycardia pacing for ventricular tachycardia among implantable cardioverter‐defibrillator recipients

Author

Yanagisawa, Satoshi, primary, Inden, Yasuya, additional, Sato, Yuki, additional, Watanabe, Ryo, additional, Goto, Takayuki, additional, Kondo, Shun, additional, Tachi, Masaya, additional, Iwawaki, Tomoya, additional, Yamauchi, Ryota, additional, Hiramatsu, Kei, additional, Shimojo, Masafumi, additional, Tsuji, Yukiomi, additional, Shibata, Rei, additional, and Murohara, Toyoaki, additional

Published
2024
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39. A novel practical algorithm using machine learning to differentiate outflow tract ventricular arrhythmia origins

Author

Shimojo, Masafumi, Inden, Yasuya, Yanagisawa, Satoshi, Suzuki, Noriyuki, Tsurumi, Naoki, Watanabe, Ryo, Nakagomi, Toshifumi, Okajima, Takashi, Suga, Kazumasa, Tsuji, Yukiomi, Murohara, Toyoaki, Shimojo, Masafumi, Inden, Yasuya, Yanagisawa, Satoshi, Suzuki, Noriyuki, Tsurumi, Naoki, Watanabe, Ryo, Nakagomi, Toshifumi, Okajima, Takashi, Suga, Kazumasa, Tsuji, Yukiomi, and Murohara, Toyoaki

Abstract

Introduction: Diagnosis of outflow tract ventricular arrhythmia (OTVA) localization by an electrocardiographic complex is key to successful catheter ablation for OTVA. However, diagnosing the origin of OTVA with a precordial transition in lead V3 (V3TZ) is challenging. This study aimed to create the best practical electrocardiogram algorithm to differentiate the left ventricular outflow tract (LVOT) from the right ventricular outflow tract (RVOT) of OTVA origin with V3TZ using machine learning. Methods: Of 498 consecutive patients undergoing catheter ablation for OTVA, we included 104 patients who underwent ablation for OTVA with V3TZ and identified the origin of LVOT (n = 62) and RVOT (n = 42) from the results. We analyzed the standard 12-lead electrocardiogram preoperatively and measured 128 elements in each case. The study population was randomly divided into training group (70%) and testing group (30%), and decision tree analysis was performed using the measured elements as features. The performance of the algorithm created in the training group was verified in the testing group. Results: Four measurements were identified as important features: the aVF/II R-wave ratio, the V2S/V3R index, the QRS amplitude in lead V3, and the R-wave deflection slope in lead V3. Among them, the aVF/II R-wave ratio and the V2S/V3R index had a particularly strong influence on the algorithm. The performance of this algorithm was extremely high, with an accuracy of 94.4%, precision of 91.5%, recall of 100%, and an F1-score of 0.96. Conclusions: The novel algorithm created using machine learning is useful in diagnosing the origin of OTVA with V3TZ.

Published
2024

44. Stereotactic radiotherapy for ventricular tachycardia: A study protocol

Author

Kawamura, Mariko, primary, Shimojo, Masafumi, additional, Inden, Yasuya, additional, Kamomae, Takeshi, additional, Okudaira, Kuniyasu, additional, Komada, Tomohiro, additional, Aoki, Sumire, additional, Shindo, Yurika, additional, Yasui, Ryotaro, additional, Yanagi, Yusuke, additional, Okumura, Masayuki, additional, Yamada, Takehiro, additional, Kozai, Yuka, additional, Oie, Yumi, additional, Kato, Yutaka, additional, Ishihara, Shunichi, additional, Murohara, Toyoaki, additional, and Naganawa, Shinji, additional

Published
2023
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45. Visualization of Repolarization Heterogeneity in Brugada Syndrome

Author

Yanagisawa, Satoshi, primary, Inden, Yasuya, additional, Goto, Takayuki, additional, Kondo, Shun, additional, Tachi, Masaya, additional, Iwawaki, Tomoya, additional, Hiramatsu, Kei, additional, Yamauchi, Ryota, additional, Shimojo, Masafumi, additional, Tsuji, Yukiomi, additional, Shibata, Rei, additional, and Murohara, Toyoaki, additional

Published
2023
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