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5 results on '"Indra Prasad, Tripathi"'

2. In silico evaluation of inhibitory potential of triterpenoids from Azadirachta indica against therapeutic target of dengue virus, NS2B-NS3 protease

Author

Vivek Dhar Dwivedi, Indra Prasad Tripathi, and Sarad Kumar Mishra

Subjects
Azadirachtin, DENV, desacetylnimbin, desacetylsalannin, drug designing, neem, nimbin, NS2B-NS3 pro, salannin, Infectious and parasitic diseases, RC109-216
Abstract

Background & objectives: NS2B-NS3 protease (NS2B-NS3 pro ) of dengue virus (DENV) is the prime therapeutic target for the development of anti-dengue drug to combat the DENV infection, which is currently an increasing health problem in many countries. In the area of antiviral drug discovery, numerous reports on the antiviral activity of various medicinal plants against dengue viruses have been published. Neem plant (Azadirachta indica) is one among those medicinal plants which is reported to show potential antiviral activity against DENV. But active principle of neem plant extract which has inhibitory potential against DENV NS2B-NS3 pro is not yet reported. The aim of the present study was to explore the inhibitory potential of five triterpenoids from neem plant, viz. nimbin, desacetylnimbin, desacetylsalannin, azadirachtin and salannin, against DENV NS2B-NS3 pro. Methods: The molecular 3D structural data of DENV NS2B-NS3 pro and selected triterpenoids of neem plant were collected from protein databank (PDB ID: 2VBC) and PubChem database respectively. The molecular docking approach was employed to find out the in silico inhibitory potential of the five triterpenoids against DENV NS2B- NS3 pro. Results: The molecular docking results showed that nimbin, desacetylnimbin and desacetylsalannin have good binding affinity with DENV NS2B-NS3 pro , while azadirachtin and salannin did not show any interaction with the target protein. It was observed that the DENV NS2B-NS3 pro binding energy for nimbin, desacetylnimbin and desacetylsalannin were -5.56, -5.24 and -3.43 kcal/mol, respectively. Interpretation & conclusion: The findings attained through this study on the molecular interaction mode of three neem triterpenoids and DENV NS2B-NS3 pro can be considered for further in vitro and in vivo validation for designing new potential drugs for DENV infection. more...

Published
2016

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3. Anti-dengue infectivity evaluation of bioflavonoid from

Author

Vivek Dhar, Dwivedi, Shiv, Bharadwaj, Sumbul, Afroz, Nooruddin, Khan, Mairaj Ahmed, Ansari, Umesh, Yadava, Ramesh Chandra, Tripathi, Indra Prasad, Tripathi, Sarad Kumar, Mishra, and Sang Gu, Kang

Subjects
Dengue, Flavonoids, Molecular Docking Simulation, Azadirachta, Protease Inhibitors, Dengue Virus, Serine Proteases, Viral Nonstructural Proteins, Antiviral Agents
Abstract

Dengue virus (DENV) serine protease enzyme, i.e. NS2B-NS3pro (non-structural protein 2B-non-structural protein 3) has been approved as prime drug target for the drug discovery against dengue infection, because of its essential role in viral replication. This study demonstrates the potential of bioflavonoids from more...

Published
2020

4. Synthesis, spectral, DFT calculations and biological activity studies of vanadyl complexes with L-aspartic acid and imidazoles/1,10-phenanthroline as co-ligands

Author

Patel, R. N., Maurya, K., Singh, Y. P., Singh, Y., Rather, S., Kamal, A., and Prof. Indra Prasad Tripathi

Subjects
TD-DFT calculations, Vanadium(IV) complexes, antidiabetic properties, ESR (electron spin resonance), DFT
Abstract

Department of Chemistry, A. P. S. University, Rewa-486 003, Madhya Pradesh, India E-mail : rnp64@ymail.com Department of Chemistry, MGCGV, Chitrakoot, Satna-485 334, Madhya Pradesh, India Manuscript received online 14 December 2016, accepted 15 December 2016 Five vanadium(IV) complexes [VO(Aspa)(L)], where Aspa = L-aspartic acid, L = imidazole, 2-methylimidazole, 2-ethylimidazole, 2-methylbenzimidazole and 1,10-phenanthroline, have been synthesized and characterized by microanalysis, FTIR, UV-Visible, ESR spectroscopy and cyclic voltammetry. The geometrical parameters of these complexes were performed by DFT and TD-DFT methods. The theoretical calculations confirm that the vanadium(IV) center exhibited square pyramidal geometry in 1-4 and distorted octahedral geometry in 5. The paramagnetic resonance g-factor and the magnetic susceptibilities (magnetic moments) of vanadyl complexes are discussed. The complexes were also tested for their in vitro antidiabetic activity (α-glucosidase inhibition activity). The complexes exhibited moderate antidiabetic properties. more...

Published
2017
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5. Synthesis of carbon nanotubes using spinach, characterization and study of magnetic properties

Author

Prof. Indra Prasad Tripathi, Tiwari, B., and Saxena, S.

Subjects
spinach, synthesis, Carbon nanotubes, characterization
Abstract

Faculty of Science and Environment, Department of Physical Sciences, Mahatma Gandhi Chitrakoot Gramodaya Vishwavidyalaya, Chitrakoot, Satna-485 001, Madhya Pradesh, India E-mail : tripathi.ip@gmail.com Director, Trident Group of Colleges, Morta, Meerut Road, Ghaziabad-201 003, Uttar Pradesh, India Department of Chemistry, Shri Venkateshwara University, Gajraula-244 236, Dt. J. P. Nagar, Uttar Pradesh, India Manuscript received 09 April 2012, accepted 12 April 2012 Nano Technology is growing at a faster pace and is leaving its impact on our day to day life. Nano materials are undoubtedly the most valuable resource in the development of this technology. So it is very essential to develop new methods to produce these materials. Keeping this view in mind CNTs were made by using protein present in spinach and metal ions as catalyst. The chemical compound, so formed was decomposed at different temperatures to obtain CNTs. These CNTs were characterized using SEM and Micro Raman spectroscopy. more...

Published
2012
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