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1. Characteristics of unnatural deaths in Tierra del Fuego, Argentina: A 10-year study (2008-2017)

Author

Roger W. Byard and Ines Aparici

Subjects
Adult, Male, Injury control, Adolescent, Accident prevention, Argentina, Mortuary Practice, Poison control, Tierra, 03 medical and health sciences, 0302 clinical medicine, Cause of Death, Suicide, Completed, Humans, 030216 legal & forensic medicine, 030212 general & internal medicine, Child, Aged, Retrospective Studies, Aged, 80 and over, Retrospective review, Health Policy, Accidents mortality, Infant, Records, Middle Aged, Issues, ethics and legal aspects, Geography, Unnatural death, Accidents, Child, Preschool, Ethnology, Female, Homicide, Law
Abstract

A retrospective review was undertaken of 287 unnatural deaths undergoing medicolegal investigation over a 10-year period from January 2008 to December 2017 in Rio Grande, Tierra del Fuego, Argentina. There were 219 males and 68 females, age range 7 months to 88 years (average 38.4 years). The 135 accidental deaths (47%) were due mainly to vehicle crashes ( N = 62) and carbon monoxide toxicity from fires ( N = 31). The 115 cases of suicides (40.1%) were predominantly due to hanging ( N = 75) and gunshot wounds ( N = 20). The 37 cases of homicide (12.9%) were mainly due to stabbing/sharp force injury ( N = 20) and blunt force trauma ( N = 9). Carbon monoxide toxicity from faulty heating accounted for a substantial percentage (8.1%) of the accidental deaths. Firearm homicides and suicides related to drug toxicity and carbon monoxide inhalation were relatively uncommon medicolegal cases in this centre.

Published
2019

2. Epidemiological surveillance of ovine hydatidosis in Tierra del Fuego, Patagonia Argentina, 1997–1999

Author

Héctor Pérez, Fabián Zanini, Ines Aparici, Gloria Edith Cerrone, Juvenal Guerrero, Celina Elissondo, Roberto Gonzalo, and Ximena Soto

Subjects
medicine.medical_specialty, Veterinary medicine, Argentina, Sheep Diseases, Biology, DNA, Mitochondrial, Polymerase Chain Reaction, Tierra, Electron Transport Complex IV, Dogs, Echinococcosis, Zoonoses, DNA, Ribosomal Spacer, parasitic diseases, Epidemiology, Genotype, Prevalence, medicine, Animals, Humans, Parasite hosting, Echinococcus granulosus, Lung, Sheep, General Veterinary, Zoonosis, General Medicine, medicine.disease, biology.organism_classification, Praziquantel, Liver, Parasitology, Restriction fragment length polymorphism, Abattoirs, Polymorphism, Restriction Fragment Length, medicine.drug
Abstract

Cystic echinococcosis is the most prevalent zoonosis in Tierra del Fuego province, Argentina, with important economic, productive and public health consequences. The present work was performed to determine the ovine prevalence in Tierra del Fuego, Argentina, as well as to evaluate the quality of diagnostic systems in slaughterhouses. Moreover, genetic analyses to characterize the strain of Echinococcus granulosus involved in the region were done. The first actions to perform a diagnosis of the epidemiological situation of hydatidosis in Tierra del Fuego were done between 1976 and 1977. A canine prevalence of 80% and an ovine prevalence of 55% results were obtained. Since 1979 the control program of Hydatidosis of Tierra del Fuego was implemented. It was based on semiannual canine anthelmintic treatment with praziquantel at dose of 5mg/kg, and complemented with sanitary education and canine and ovine epidemiological surveillance. During May 1997-January 1999: 5,916 sheep coming from 20 farms of the programmatic area were evaluated. In the lamb category, hydatid cysts were not found. In the adults category, 62 infected animals were found (3.2%). The ovine prevalence was 1.1% and there was 100% of coincidence between diagnosis in the slaughterhouse, re-inspection in the laboratory and histopathological study. The marked decrease in the prevalence observed for sheep infection evidenced a destabilization of the biological cycle of the parasite. This could be explained by the application of a control program with uninterrupted systematic actions. Polymerase chain reaction-ribosomal ITS-1 DNA (rDNA) restriction fragment length polymorphism (PCR-RFLP) analysis and partial sequencing of the mitochondrial cytochrome c oxidase subunit 1 (CO1) gene were used to characterize E. granulosus isolates collected from different regions of Tierra del Fuego to determine which genotypes occurred in this region. The results revealed the presence of the G1 genotype (sheep-dog strain). This is the first time that a molecular analysis was performed for the E. granulosus isolates from Tierra del Fuego.

Published
2006
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3. Recomendações na Abordagem do Doente com Hidradenite Supurativa

Author

Joana Cabete and Inês Aparício Martins

Subjects
Hidradenite Supurativa/cirurgia, Hidradenite Supurativa/diagnóstico, Hidradenite Supurativa/tratamento, Medicine, Medicine (General), R5-920
Abstract

A hidradenite supurativa é uma dermatose inflamatória crónica e recorrente que se caracteriza pela presença de nódulos inflamatórios e abcessos nas áreas ricas em glândulas apócrinas, que podem evoluir para fístulas supurativas e cicatrizes. Apesar de ser considerada uma das patologias dermatológicas com maior impacto na qualidade de vida dos doentes, é frequentemente subdiagnosticada. A hidradenite supurativa, sobretudo nas suas formas mais graves, associa-se a diversas comorbilidades, pelo que é fundamental adotar uma perspetiva holística e multidisciplinar na gestão destes doentes. A abordagem terapêutica é complexa e desafiante. A terapêutica médica é multifacetada e deve ser adaptada à apresentação clínica e gravidade da doença. A terapêutica cirúrgica deverá ser equacionada como adjuvante à terapêutica médica, em particular nos casos refratários e perante cicatrizes ou mutilação anatómica e/ou funcional. As presentes recomendações pretendem reunir os principais aspetos da abordagem ao doente com hidradenite supurativa e destinam-se a todos os profissionais de saúde envolvidos no seu acompanhamento.

Published
2023
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5. Abstracts of papers Rational use of drugs

Author

M. N. G. Dukes, Robert M. Elenbaas, G. Tognoni, Dorothy L. Smith, Inga Lunde, H. G. M. Leufkens, Y. A. Hekster, A. Bakker, G. Ostino, H. Petri, F. Sturmans, H. D. Banta, F. F. H. Rutten, L. L. Martens, P. R. Noyce, F. W. H. M. Merkus, Lolkje de Jong-v.d.Berg, Flora Haaijer-Ruskamp, Graham Dukes, B. -M. Vidgren, S. Vidgren, N. Martini, M. L. Sala, G. Scroccaro, P. Olivencia, D. C. McLcod, W. G. Coln, A. G. Hartzcma, C. F. Thaver, J. M. Rodriguez-Sasiain, B. Sangroniz, M. D. Mauleon, M. A. Wood, M. J. Martinez, O. Leinebø, J. N. Saugen, P. Marini, R. Olivato, C. Alberola, E. Cruz-Martos, T. Cruz, N. Marfagon, A. Herreros de Tejada, P. Denig, F. M. Haaijer-Ruskamp, H. Wesseling, A. Versluis, M. P. Gascón, Robert Horne, Jane Hough, N. S. Klazinga, J. J. -E. van Everdingen, P. J. van den Broek, D. K. Roberts, G. B. A. Veitch, K. K. C. Tan, D. A. Holland, M. C. Allwood, A. Nicholls, A. Astobieta, R. Calvo, J. M. Rodriquez-Sasiain, D. Barriquand, C. Pochon, G. Aulagner, A. Vial, C. Dumarest, P. H. Maire, R. W. Jelliffe, J. R. B. J. Brouwers, K. Cramer, J. Gulyas, H. J. vd Kam, J. Sijtsma, C. Donadio, G. Tramonti, G. Garcea, M. Costagli, A. Lucchetti, R. Giordani, G. Paizis, R. Pierotti, G. Falcone, C. Bianchi, C. Gallastegui, R. Farré, I. Jiménez, M. A. Mangues, E. Guasch, G. Ginovart, X. Sagrera, F. Raspall, J. M. Queralto, J. M. Kovarik, C. M. A. Rademaker, J. Verhoef, L. Silvestri, M. Caputo, M. Andrew, E. -L. Toverud, I. Jimenez, I. Castro, E. Alvarez, J. Altimiras, J. J. J. P. M. van de Leur, N. F. Muller, J. M. Van Turnhout, L. Mendizabal, J. M. Rodriguez Sasiain, G. Morana, K. Moss Ofstad, A. -M. Timenes, J. K. F. Vroom, L. T. W. de Jong-van den Berg, P. B. van den Berg, J. J. de Gier, J. Ferres, O. Recoder, Rio T. Sanchez, M. P. Garcia, A. Julia, A. Balet, R. Farre, M. A. Manques, T. Berod, E. Dufay, C. Naveau, M. Combe, A. Sauvageon, Erik Wind Hansen, Jens Dencker Christensen, L. Lie-A-Huen, J. H. Kinqma, D. K. P. Meijer, F. Le Meur, P. Isoard, M. S. Salek, A. Y. Finlay, G. K. Khan, D. K. Luscombe, A. Stuurman, M. P. Boidin, K. Wallenius, R. Ojala, A. Kariluoto, M. Ikonen, A. H. P. Paes, A. Th. G. Blom, S. Wallenius, H. Enlund, K. Vainio, C. Codina, M. Roca, P. Sardà, N. Corominas, J. Massó, J. Ribas, K. Kentra, M. Myllyntausta, M. Saarenpää, M. S. A. Airaksinen, L. Mendarte, A. Rimola, R. Meisters, Y. Hekster, W. Janssen, A. Cox, R. Kempen, S. J. A. Aerdts, R. van Dalen, H. A. L. Clasener, J. Festen, PP Schjphorst, HB Benraad, P. van Asten, R. de Wit, R. J. G. Limbeek, H. G. M. Nagel, R. H. B. Mgyboom, B. H. C. Stricker, B. A. M. van den Berg, T. H. A. Nelen, T. A. G. Tijssen, P. Wassink, M. J. E. Wassink-L'Ortije, P. Gascón, C. Selva, T. Bassons, C. Pardo, M. P. Mas, M. Saqalés, F. Sánchez, V. Mercade, R. Pujol, C. Agustí, M. Cano, T. Gurrera, M. Gorchs, X. Fabregas, L. L. Murgui, A. Verdaguer, W. P. J. Witjes, E. J. Vollaard, B. J. P. Crul, C. Limpens, K. Ahonen, T. Klaukka, I. Vohlonen, J. Martikainen, Daniel Goldenberg, Andres Brodsky, Ines Aparici, Cecilia Argeri, D. Goldenberg, C. Saidman, L. Sevinski, N. Allevato, B. Mujico, J. Ubogui, P. Dorfman, Lupo L. Rodriguez, M. Varela, J. Higa, Annie Fourrier, Philippe Larrouturou, Claire Samarran, Jacqueline Huchet, N. D. Barber, N. Party, P. Wilson, Grethe Eide, Kari Horvei, Angelika Kruse-Jensen, Ingrid Wold, Turid Møark, C. W. Barrett, A. C. Tugwell, B. Søndergaard, M. Rasmussen, F. Davidsen, H. Hey, L. Kierkeby, L. Riis, M. Korhonen, P. Vidgren, T. Ojanen, M. Vidqren, J. Ferrés, T. Sanchez, C. Gallastequi, A. Julià, R. M. C. Herings, B. H. Ch. Stricker, A. J. H. H. Janssen, Heike Dinter, A. J. H. M. Janssen, X. Barbaut, S. Proust, G. Amlagner, F. A. L. M. Eskens, E. Arnoldussen, E. Sieradzki, E. Wanat-Słupska, M. Zlółkowska, I. Pankowska, R. Mazur, B. Ksiazkiewicz, A. Jankowski, A. Marzec, C. Marzec, M. O. Marzec, J. P. Marzec, D. R. Mungall, Lynne Portnoy, F. Lucas, F. Kadir, A. Pijpers, A. Vulto, J. Zuidema, P. Sutton, Antal Samu, John E. Murphy, Ronnie Chapman, Nicolien Wieringa, J. Rolloos, M. T. P. J. Voesten, P. J. J. de Meijer, G. H. P. de Koning, S. Salek, E. Reerink, L. Farrow, G. Raskob, D. Rosenbloom, R. Hull, A. Torras, O. Recorder, C. Torras, J. Cubellsl, M. Font, R. Madridejos, A. Catalán, M. Huguet, N. Franquesa, J. Gratacós, M. Martinez, A. Saltó, E. van der Kleijn, R. J. M. ter Wee, N. Holmberg, and R. F. Brenninkmeijer

Subjects
Pharmacology, Medical education, business.industry, Pharmacology (medical), Pharmacy, business, Psychology, Rational use
Published
1989
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6. Stevens-Johnson syndrome, respiratory distress and acute renal failure due to synergic bleomycin-cisplatin toxicity

Author

Daniel Goldenberg, Cecilia Argeri, Ines Aparici, and Andres L. Brodsky

Subjects
medicine.medical_specialty, Pathology, Uterine Cervical Neoplasms, Bleomycin, Gastroenterology, Nephrotoxicity, chemistry.chemical_compound, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Pharmacology (medical), Adverse effect, Pneumonitis, Pharmacology, Kidney, Respiratory Distress Syndrome, Newborn, Respiratory distress, business.industry, Respiratory disease, Infant, Newborn, respiratory system, Acute Kidney Injury, Middle Aged, medicine.disease, respiratory tract diseases, medicine.anatomical_structure, Epidermoid carcinoma, chemistry, Stevens-Johnson Syndrome, Carcinoma, Squamous Cell, Female, Cisplatin, business
Abstract

A patient presenting with a cervix uteri epidermoid carcinoma had acute renal failure after treatment with cisplatin and bleomycin. She later developed fatal bleomycin-induced pneumonitis and Stevens-Johnson syndrome. This is a very rare association of adverse effects. The risk of causing a drug interaction thus increasing the severity of bleomycin undesired effects must be taken into account when a nephrotoxic drug is added to the former. The authors stress the importance of monitoring renal function under these conditions.

Published
1989

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