Search

Your search keyword '"Infante, Barbara"' showing total 270 results
Start Over Author "Infante, Barbara"
270 results on '"Infante, Barbara"'

1. Safety and efficacy of tixagevimab/cilgavimab for pre-exposure prophylaxis in kidney transplant recipients: a multicenter retrospective cohort study

Author

Simone, Simona, Pronzo, Virginia, Pesce, Francesco, Bavaro, Davide Fiore, Infante, Barbara, Mercuri, Silvia, Schirinzi, Annalisa, Panaro, Antonella, Conte, Eleonora, Belati, Alessandra, Troise, Dario, Pontrelli, Paola, Conserva, Francesca, Gallo, Pasquale, Panico, Maddalena, Spilotros, Marco, Lucarelli, Giuseppe, Saracino, Annalisa, Stallone, Giovanni, Di Serio, Francesca, Ditonno, Pasquale, and Gesualdo, Loreto

Published
2024
Full Text
View/download PDF

3. mTOR and SGLT-2 Inhibitors: Their Synergistic Effect on Age-Related Processes.

Author

Troise, Dario, Mercuri, Silvia, Infante, Barbara, Losappio, Vincenzo, Cirolla, Luciana, Netti, Giuseppe Stefano, Ranieri, Elena, and Stallone, Giovanni

Subjects
MTOR inhibitors, CELL growth, DRUG development, MEDICAL care costs, AGING
Abstract

The aging process contributes significantly to the onset of chronic diseases, which are the primary causes of global mortality, morbidity, and healthcare costs. Numerous studies have shown that the removal of senescent cells from tissues extends lifespan and reduces the occurrence of age-related diseases. Consequently, there is growing momentum in the development of drugs targeting these cells. Among them, mTOR and SGLT-2 inhibitors have garnered attention due to their diverse effects: mTOR inhibitors regulate cellular growth, metabolism, and immune responses, while SGLT-2 inhibitors regulate glucose reabsorption in the kidneys, resulting in various beneficial metabolic effects. Importantly, these drugs may act synergistically by influencing senescence processes and pathways. Although direct studies on the combined effects of mTOR inhibition and SGLT-2 inhibition on age-related processes are limited, this review aims to highlight the potential synergistic benefits of these drugs in targeting senescence. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. How histopathological diagnosis interacts with kidney ultrasound parameters to predict glomerular filtration rate

Author

Andrulli, Simeone, primary, Gigante, A, additional, Rossini, Michele, additional, D'Angiò, Pierluigi, additional, Vischini, Gisella, additional, Lucchetta, Franca, additional, Aucella, Filippo, additional, Valsecchi, Giovanni, additional, Infante, Barbara, additional, Vario, Maria Giovanna, additional, Giannese, Domenico, additional, Granata, Antonio, additional, Moggia, Elisabetta, additional, Gembillo, Guido, additional, Cianci, Rosario, additional, Bonomini, Mario, additional, Manenti, Flavia, additional, Lazzarin, Roberta, additional, Renzo, Brigida Di, additional, Zanchelli, Fulvia, additional, Garozzo, Maurizio, additional, Manes, Massimo, additional, Battaglia, Yuri, additional, Sciri, Raffaella, additional, De Fabritiis, Marco, additional, Quaglia, Marco, additional, Cavoli, Gioacchino Li, additional, Gintoli, Enrica, additional, Conte, Maria Maddalena, additional, Borzumati, Maurizio, additional, Benozzi, Luisa, additional, Pasquariello, Giovanna, additional, Andrulli, Giovanni, additional, Leoni, Marco, additional, Seminara, Giuseppe, additional, Corbari, Valentina, additional, Sabiu, Gianmarco, additional, Maggio, Arcangelo Di, additional, Pollastro, Rosa Maria, additional, and Gesualdo, Loreto, additional

Published
2024
Full Text
View/download PDF

6. Development and testing of an artificial intelligence tool for predicting end-stage kidney disease in patients with immunoglobulin A nephropathy

Author

Tesar, V., Maixnerova, D., Lundberg, S., Gesualdo, L., Emma, F., Fuiano, L., Beltrame, G., Rollino, C., Coppo, R., Amore, A., Camilla, R., Peruzzi, L., Praga, M., Feriozzi, S., Polci, R., Segoloni, G., Colla, L., Pani, A., Angioi, A., Piras, L., Feehally, J., Cancarini, G., Ravera, S., Durlik, M., Moggia, E., Ballarin, J., Di Giulio, S., Pugliese, F., Serriello, I., Caliskan, Y., Sever, M., Kilicaslan, I., Locatelli, F., Del Vecchio, L., Wetzels, J.F.M., Peters, H., Berg, U., Carvalho, F., da Costa Ferreira, A.C., Maggio, M., Wiecek, A., Ots-Rosenberg, M., Magistroni, R., Topaloglu, R., Bilginer, Y., D’Amico, M., Stangou, M., Giacchino, F., Goumenos, D., Papasotiriou, M., Galesic, K., Toric, L., Geddes, C., Siamopoulos, K., Balafa, O., Galliani, M., Stratta, P., Quaglia, M., Bergia, R., Cravero, R., Salvadori, M., Cirami, L., Fellstrom, B., Smerud, H. Kloster, Ferrario, F., Stellato, T., Egido, J., Martin, C., Floege, J., Eitner, F., Rauen, T., Lupo, A., Bernich, P., Menè, P., Morosetti, M., van Kooten, C., Rabelink, T., Reinders, M.E.J., Grinyo, J.M. Boria, Cusinato, S., Benozzi, L., Savoldi, S., Licata, C., Mizerska-Wasiak, M., Roszkowska-Blaim, M., Martina, G., Messuerotti, A., Canton, A. Dal, Esposito, C., Migotto, C., Triolo, G., Mariano, F., Pozzi, C., Boero, R., Mazzucco, Giannakakis, C., Honsova, E., Sundelin, B., Di Palma, A.M., Gutiérrez, E., Asunis, A.M., Barratt, J., Tardanico, R., Perkowska-Ptasinska, A., Terroba, J. Arce, Fortunato, M., Pantzaki, A., Ozluk, Y., Steenbergen, E., Soderberg, M., Riispere, Z., Furci, L., Orhan, D., Kipgen, D., Casartelli, D., GalesicLjubanovic, D., Gakiopoulou, H., Bertoni, E., Ortiz, P. Cannata, Karkoszka, H., Groene, H.J., Stoppacciaro, A., Bajema, I., Bruijn, J., FulladosaOliveras, X., Maldyk, J., Ioachim, E., Abbrescia, Daniela, Kouri, Nikoleta, Stangou, Maria, Papagianni, Aikaterini, Scolari, Francesco, Delbarba, Elisa, Bonomini, Mario, Piscitani, Luca, Stallone, Giovanni, Infante, Barbara, Godeas, Giulia, Madio, Desiree, Biancone, Luigi, Campagna, Marco, Zaza, Gianluigi, Squarzoni, Isabella, Cangemi, Concetta, Schena, Francesco Paolo, Anelli, Vito Walter, Trotta, Joseph, Di Noia, Tommaso, Manno, Carlo, Tripepi, Giovanni, D’Arrigo, Graziella, Chesnaye, Nicholas C., Russo, Maria Luisa, Zoccali, Carmine, Tesar, Vladimir, and Coppo, Rosanna

Published
2021
Full Text
View/download PDF

8. Dendritic Cells: A Bridge between Tolerance Induction and Cancer Development in Transplantation Setting.

Author

Troise, Dario, Infante, Barbara, Mercuri, Silvia, Catalano, Valeria, Ranieri, Elena, and Stallone, Giovanni

Subjects
DENDRITIC cells, CARCINOGENESIS, IMMUNE response, CANCER cells, GRAFT survival
Abstract

Dendritic cells (DCs) are a heterogeneous group of antigen-presenting cells crucial for fostering allograft tolerance while simultaneously supporting host defense against infections and cancer. Within the tumor microenvironment, DCs can either mount an immune response against cancer cells or foster immunotolerance, presenting a dual role. In immunocompromised individuals, posttransplant malignancies pose a significant health concern, with DCs serving as vital players in immune responses against cancer cells. Both recipient- and donor-derived DCs play a critical role in the rejection process, infiltrating the transplanted organ and sustaining T-cell responses. The use of immunosuppressive drugs represents the predominant approach to control this immunological barrier in transplanted organs. Evidence has shed light on the immunopharmacology of these drugs and novel strategies for manipulating DCs to promote allograft survival. Therefore, comprehending the mechanisms underlying this intricate microenvironment and the effects of immunosuppressive therapy on DCs is crucial for developing targeted therapies to reduce graft failure rates. This review will delve into the fundamental immunobiology of DCs and provide a detailed exploration of their clinical significance concerning alloimmune responses and posttransplant malignancies. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

9. Case Report: Tocilizumab for Acute Kidney Graft Dysfunction in Patient Affected by COVID-19

Author

Infante Barbara, Mercuri Silvia, Troise Dario, Castellano Giuseppe, and Giovanni Stallone

Subjects
COVID-19, tocilizumab, graft dysfunction, acute kidney injury, transplantation, Medicine (General), R5-920
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was isolated in January 2020 and, on March, the WHO declared the status of a pandemic. It causes a cytokine release syndrome, called “cytokine storm,” characterized by systemic inflammation involving elevated levels of cytokines and hyperactivation of immune cell; this profound alteration in the immune system led to an overshooting inflammatory response contributing to morbidity and mortality. Solid organ transplant recipients are at particularly higher risk of developing critical coronavirus disease 2019 (COVID-19) due to chronic immunosuppression; in fact, establishing the balance between infection and rejection in any transplant recipient is the principal aim when prescribing immunosuppression. Tocilizumab, a humanized monoclonal antibody against interleukin-6 (IL-6) receptor widely adopted in adult rheumatoid arthritis, is used as rescue therapy for chronic antibody-mediated rejection in kidney transplantation. Data about the use of tocilizumab for treating acute kidney graft dysfunction in a setting of kidney-transplanted patients affected by COVID-19 are lacking. In this case study, we discuss the case of kidney transplant recipient with proven SARS-CoV-2 infection that develops acute graft dysfunction and the management of immunosuppression with concomitant tocilizumab administration.

Published
2021
Full Text
View/download PDF

13. Pentraxin 3 in Kidney Disease and Renal Replacement Therapies

Author

Vincenzo Losappio, Infante Barbara, Annamaria Maiorano, Serena Simiele, Sara Rosato, Silvia Mercuri, Dario Troise, Giovanni Stallone, and Paola Pontrelli

Abstract

Chronic kidney disease (CKD) is actually considered a public health priority according to the increasing number of patients affected by this condition: this casuistry is not only related to specific glomerular, tubular or autoimmune diseases or a consequence of acute kidney injury (AKI) episodes leading to organ failure, but it is tied to the progression of life expectancy and the impact of comorbidities such as cardiovascular disease, diabetes and cancer. CKD and its comorbidities promote low grade inflammatory status with an impact on patients’ clinical conditions, reducing their possibility for kidney transplantation or graft survival and their survival when receiving renal replacement therapies such as hemodialysis (HD) or peritoneal dialysis (PD). CKD is often referred to as an ageing accelerator: innate immune system dysregulation, in the uraemic proinflammatory milieu, is involved in this accelerated senescence phenomena and pentraxins, particularly Pentraxin-3 (PTX-3), are of particular interest in the development of kidney disease. A complete understanding of the mechanism of CKD progression, innate immune system involvement and a proper definition of PTX-3 role in kidney disease, could redefine the approach for diagnosis and a more centered patients’ management to slow down CKD progression over time and reduce its clinical and social impact.

Published
2023

14. Validation of PLASMIC score and follow-up data in a cohort of patients with suspected microangiopathies from Southern Italy

Author

Tiscia, Giovanni Luca, Ostuni, Angelo, Cascavilla, Nicola, Cappucci, Filomena, Scalzulli, Potito, Battista, Cosima, Abrescia, Antonio, Aucella, Filippo, Buquicchio, Caterina, Brigante, Maurizio, D’Andrea, Giovanna, Di Paolo, Bruno, Giordano, Giulio, Infante, Barbara, Piano, Silvia, Ranieri, Prudenza, Tullo, Livio, and Grandone, Elvira

Published
2018
Full Text
View/download PDF

15. Recent advances in molecular mechanisms of acute kidney injury in patients with diabetes mellitus

Author

Infante, Barbara, primary, Conserva, Francesca, additional, Pontrelli, Paola, additional, Leo, Serena, additional, Stasi, Alessandra, additional, Fiorentino, Marco, additional, Troise, Dario, additional, dello Strologo, Andrea, additional, Alfieri, Carlo, additional, Gesualdo, Loreto, additional, Castellano, Giuseppe, additional, and Stallone, Giovanni, additional

Published
2023
Full Text
View/download PDF

16. Unraveling the Link between Interferon-α and Systemic Lupus Erythematosus: From the Molecular Mechanisms to Target Therapies

Author

Infante, Barbara, primary, Mercuri, Silvia, additional, Dello Strologo, Andrea, additional, Franzin, Rossana, additional, Catalano, Valeria, additional, Troise, Dario, additional, Cataldo, Emanuela, additional, Pontrelli, Paola, additional, Alfieri, Carlo, additional, Binda, Valentina, additional, Frontini, Giulia, additional, Netti, Giuseppe Stefano, additional, Ranieri, Elena, additional, Gesualdo, Loreto, additional, Castellano, Giuseppe, additional, and Stallone, Giovanni, additional

Published
2022
Full Text
View/download PDF

17. mTOR inhibitors improve both humoral and cellular response to SARS-CoV-2 messenger RNA BNT16b2 vaccine in kidney transplant recipients

Author

Netti, Giuseppe S., primary, Infante, Barbara, additional, Troise, Dario, additional, Mercuri, Silvia, additional, Panico, Maddalena, additional, Spadaccino, Federica, additional, Catalano, Valeria, additional, Gigante, Margherita, additional, Simone, Simona, additional, Pontrelli, Paola, additional, Gesualdo, Loreto, additional, Ranieri, Elena, additional, Castellano, Giuseppe, additional, and Stallone, Giovanni, additional

Published
2022
Full Text
View/download PDF

18. The risks associated with percutaneous native kidney biopsies: a prospective study.

Author

Andrulli, Simeone, Rossini, Michele, Gigliotti, Giuseppe, Manna, Gaetano La, Feriozzi, Sandro, Aucella, Filippo, Granata, Antonio, Moggia, Elisabetta, Santoro, Domenico, Manenti, Lucio, Infante, Barbara, Ferrantelli, Angelo, Cianci, Rosario, Giordano, Mario, Giannese, Domenico, Seminara, Giuseppe, Luca, Marina Di, Bonomini, Mario, Spatola, Leonardo, and Bruno, Francesca

Subjects
RENAL biopsy, LONGITUDINAL method, ODDS ratio, LOGISTIC regression analysis, BLOOD transfusion, BLOOD transfusion reaction
Abstract

Background The known risks and benefits of native kidney biopsies are mainly based on the findings of retrospective studies. The aim of this multicentre prospective study was to evaluate the safety of percutaneous renal biopsies and quantify biopsy-related complication rates in Italy. Methods The study examined the results of native kidney biopsies performed in 54 Italian nephrology centres between 2012 and 2020. The primary outcome was the rate of major complications 1 day after the procedure, or for longer if it was necessary to evaluate the evolution of a complication. Centre and patient risk predictors were analysed using multivariate logistic regression. Results Analysis of 5304 biopsies of patients with a median age of 53.2 years revealed 400 major complication events in 273 patients (5.1%): the most frequent was a ≥2 g/dL decrease in haemoglobin levels (2.2%), followed by macrohaematuria (1.2%), blood transfusion (1.1%), gross haematoma (0.9%), artero-venous fistula (0.7%), invasive intervention (0.5%), pain (0.5%), symptomatic hypotension (0.3%), a rapid increase in serum creatinine levels (0.1%) and death (0.02%). The risk factors for major complications were higher plasma creatinine levels [odds ratio (OR) 1.12 for each mg/dL increase, 95% confidence interval (95% CI) 1.08–1.17], liver disease (OR 2.27, 95% CI 1.21–4.25) and a higher number of needle passes (OR for each pass 1.22, 95% CI 1.07–1.39), whereas higher proteinuria levels (OR for each g/day increase 0.95, 95% CI 0.92–0.99) were protective. Conclusions This is the first multicentre prospective study showing that percutaneous native kidney biopsies are associated with a 5% risk of a major post-biopsy complication. Predictors of increased risk include higher plasma creatinine levels, liver disease and a higher number of needle passes. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

19. Pre-Transplant Expression of CCR-2 in Kidney Transplant Recipients Is Associated With the Development of Delayed Graft Function

Author

Pontrelli, Paola, primary, Simone, Simona, additional, Rascio, Federica, additional, Pesce, Francesco, additional, Conserva, Francesca, additional, Infante, Barbara, additional, Castellano, Giuseppe, additional, Sallustio, Fabio, additional, Fiorentino, Marco, additional, Zaza, Gianluigi, additional, Gallone, Anna, additional, Battaglia, Michele, additional, Ditonno, Pasquale, additional, Stallone, Giovanni, additional, Gesualdo, Loreto, additional, and Grandaliano, Giuseppe, additional

Published
2022
Full Text
View/download PDF

20. Emerging biomarkers of delayed graft function in kidney transplantation

Author

Mezzolla, Valeria, primary, Pontrelli, Paola, additional, Fiorentino, Marco, additional, Stasi, Alessandra, additional, Pesce, Francesco, additional, Franzin, Rossana, additional, Rascio, Federica, additional, Grandaliano, Giuseppe, additional, Stallone, Giovanni, additional, Infante, Barbara, additional, Gesualdo, Loreto, additional, and Castellano, Giuseppe, additional

Published
2021
Full Text
View/download PDF

25. Prospective Validation of Pentraxin-3 as a Novel Serum Biomarker to Predict the Risk of Prostate Cancer in Patients Scheduled for Prostate Biopsy

Author

Falagario, Ugo Giovanni, primary, Busetto, Gian Maria, additional, Netti, Giuseppe Stefano, additional, Sanguedolce, Francesca, additional, Selvaggio, Oscar, additional, Infante, Barbara, additional, Ranieri, Elena, additional, Stallone, Giovanni, additional, Carrieri, Giuseppe, additional, and Cormio, Luigi, additional

Published
2021
Full Text
View/download PDF

26. mTOR inhibition improves mitochondria function/biogenesis and delays cardiovascular aging in kidney transplant recipients with chronic graft dysfunction

Author

Infante, Barbara, primary, Bellanti, Francesco, additional, Correale, Michele, additional, Pontrelli, Paola, additional, Franzin, Rossana, additional, Leo, Serena, additional, Calvaruso, Martina, additional, Mercuri, Silvia, additional, Netti, Giuseppe Stefano, additional, Ranieri, Elena, additional, Brunetti, Natale Daniele, additional, Grandaliano, Giuseppe, additional, Gesualdo, Loreto, additional, Serviddio, Gaetano, additional, Castellano, Giuseppe, additional, and Stallone, Giovanni, additional

Published
2021
Full Text
View/download PDF

31. Sirolimus for Kaposi's sarcoma in renal-transplant recipients

Author

Stallone, Giovanni, Schena, Antonio, Infante, Barbara, Maggio, Giulio, Ranieri, Elena, Gesualdo, Loreto, Schena, Francesco Paolo, Grandaliano, Giuseppe, Paolo, Salvatore Di, and Loverre, Antonella

Subjects
Organ transplant recipients -- Health aspects, Kaposi's sarcoma -- Research
Abstract

The cellular and clinical effect of sirolimus on Kaposi's sarcoma in renal-transplant recipients is investigated. Results reveal that sirolimus inhibits the progression of dermal Kaposi's sarcoma in kidney-transplant recipients while providing effective immunosuppression.

Published
2005

36. IgE-Mediated Immune Response and Antibody-Mediated Rejection

Author

Rascio, Federica, primary, Pontrelli, Paola, additional, Netti, Giuseppe Stefano, additional, Manno, Elisabetta, additional, Infante, Barbara, additional, Simone, Simona, additional, Castellano, Giuseppe, additional, Ranieri, Elena, additional, Seveso, Michela, additional, Cozzi, Emanuele, additional, Gesualdo, Loreto, additional, Stallone, Giovanni, additional, and Grandaliano, Giuseppe, additional

Published
2020
Full Text
View/download PDF

40. P1752THE ROLE OF MTOR INHIBITORS ON CARDIOVASCULAR AGING IN RENAL TRANSPLANT PATIENTS WITH CHRONIC GRAFT DYSFUNCTION

Author

Infante, Barbara, primary, Castellano, Giuseppe, primary, Prisciandaro, Concetta, primary, Dilorenzo, Adelaide, primary, Bellanti, Francesco, primary, Coviello, Nicola, primary, Pontrelli, Paola, primary, Rascio, Federica, primary, FRANZIN, ROSSANA, primary, Gesualdo, Loreto, primary, Serviddio, Gaetano, primary, Grandaliano, Giuseppe, primary, and Stallone, Giovanni, primary

Published
2020
Full Text
View/download PDF

42. Kidney biopsy in the elderly

Author

Palma, Anna Maria Di, dʼApollo, Anna Maria, Vendemia, Franco, Stallone, Giovanni, Infante, Barbara, and Gesualdo, Loreto

Published
2010

44. Serum Levels of BAFF and APRIL Predict Clinical Response in Anti-PLA2R-Positive Primary Membranous Nephropathy

Author

Netti, Giuseppe Stefano, primary, Infante, Barbara, additional, Spadaccino, Federica, additional, Godeas, Giulia, additional, Corallo, Maria Grazia, additional, Prisciandaro, Concetta, additional, Croce, Laura, additional, Rotondi, Mario, additional, Gesualdo, Loreto, additional, Stallone, Giovanni, additional, Grandaliano, Giuseppe, additional, and Ranieri, Elena, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results