1. Evaluation of different heterologous-homologous vaccine regimens against challenge with GI-23 lineage infectious bronchitis virus.
- Author
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Houta MH, Hassan KE, Kilany WH, Shany SAS, El-Sawah AA, ElKady MF, Abdel-Moneim AS, and Ali A
- Subjects
- Animals, Vaccination veterinary, Virus Shedding, Trachea virology, Antibodies, Viral blood, Antibodies, Viral immunology, Vaccine Efficacy, Infectious bronchitis virus immunology, Infectious bronchitis virus genetics, Chickens virology, Poultry Diseases prevention & control, Poultry Diseases virology, Poultry Diseases immunology, Coronavirus Infections veterinary, Coronavirus Infections prevention & control, Coronavirus Infections virology, Coronavirus Infections immunology, Viral Vaccines immunology, Viral Vaccines administration & dosage, Vaccines, Attenuated immunology, Vaccines, Attenuated administration & dosage
- Abstract
This study assesses different IBV vaccination regimens in broiler chickens using commercially available live attenuated GI-23 (Egyptian-VAR2) and GI-1 (H120) vaccines. Vaccines were administered at 1, 14 days of age, or both. The ciliostasis test, following wild-type VAR2 challenge at 28 days of age, indicated that classic H120+VAR2 at one day old followed by the VAR2 vaccine at 14 days of age provided the highest level of protection (89.58%). Similarly, administering VAR2 at 1 day of age and classic H120 at 14 days of age demonstrated substantial protection (85.42%). Conversely, administering only classic H120 and VAR2 at one day old resulted in the lowest protection level (54.17%). Tracheal virus shedding quantification and assessment of trachea and kidney degenerative changes were significantly lower in vaccinated groups compared to the unvaccinated-challenged group. In conclusion, a carefully planned vaccination regimen based on homologous vaccination offers the most effective clinical protection in broiler chickens., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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