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7 results on '"Inflamación subclínica"'

1. SUBCLINICAL INFLAMMATION BIOMARKERS IN AN INFANT-JUVENILE PATIENTS WITH TYPE 1 DIABETES

Author

Adela Abregú, Teresita Carrizo, Elba Díaz, Cristina Fonio, and Cristina Bazán

Subjects
diabetes, inflamación subclínica, citoquinas proinflamatorias, pcrus., Nutritional diseases. Deficiency diseases, RC620-627, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Type 1 diabetes (T1D) is associated with an increased risk of vascular complications. Proinflammatory cytokines IL-6, MCP-1 and TNF-α, have been implicated in the development of these complications. The aim of this study was to determine the plasma levels of IL-6, MCP-1, TNF-α, hsPCR and fibrinogen (Fg) in patients with infant-juvenile DT1 and its association with the glycemic control degree and time to progression of disease. Forty-five DT1 patients (24 m/21 w), age 11,2±1,8 years, with a time to progression of disease of 3,1±3,0 years, without vascular complications, were studied and compared with 20 healthy subjects. Plasma levels of IL-6, MCP-1 and TNF-α, Fg, hsPCR, leukocyte count, fasting blood glucose and HbA1c were determined. The presence of retinopathy and nephropathy was rule out. Data were analyzed with the Windows software SPSS 15. Diabetic children had higher levels of IL-6 (1,10±0,74 vs 0,68±0,19 pg/ml; p=0,005), MCP-1 (130±49 vs 95±18 pg/ml, p=0,02), hsPCR (1,02±1,07 vs 0,43 ±026 mg/l; p=0,007) Fg (299±59 vs 246±18 mg/dl, p=0,0001) with respect to controls. No significant difference of TNF-α between both groups were observed. When diabetic patients were grouped according to glycemic control degree (HbA1c 3 years), no significant differences were found in the molecules studied. In diabetic patients, HbA1c was correlated with IL-6, MCP-1 and hsPCR. These results reflect a proinflammatory state in the diabetic population studied.

Published
2015
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2. Consumption of fruits and vegetables and C-reactive protein in women undergoing cosmetic surgery Consumo de frutas y vegetales, y proteína C-reactiva en mujeres sometidas a cirugía cosmética

Author

R. L. F. C. Lima, M. J. C. Costa, R. G. Filizola, L. S. R. Asciutti, R. F. Leite, A. S. M. Ferreira, and J. Faintuch

Subjects
Intervención nutricional, Frutas, Vegetales, Proteína C reactiva, Cirugía cosmética, Inflamación subclínica, Nutritional intervention, Fruits, Vegetables, C-Reactive Protein, Cosmetic surgery, Subclinical inflammation, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Low-grade inflammation adversely influences metabolism and cardiovascular prognosis, nevertheless increased intake of fruits and vegetables has rarely been studied in this context. Objective: In a prospective controlled study, the effect on C-reactive protein (CRP) levels was assessed. Methodology: Sixty consecutive women undergoing cosmetic abdominal surgery were instructed to consume six servings each of fruits and vegetables during the first postoperative month. Detailed 24h interviewer-administered dietary recall was conducted at baseline and at the end of the study, with weekly returns to monitor unscheduled dietary changes and compliance with the protocol. Variance (ANOVA) and covariance (ANCOVA) were evaluated to confirm significance and minimize confounding variables. Results: No differences concerning age (42.2 ± 5.3 vs 41.1 ± 6.0 years) or BMI (25.5± 3.1 vs 25.0± 3.0 kg/m²) occurred. Ingestion of fruits increased to approximately 5.2 vs 3.9 and of vegetables 5.9 vs 3.4 servings/ day, respectively. CRP decreased more conspicuously in the treated group (P=0.028), and correlation between vitamin C input and CRP in supplemented participants was demonstrated (P=0.014). Conclusions: Higher intake of antioxidant foods was feasible, and an antiinflammaotory effect occurred. Further studies with longer administration and follow-up period are recommended.Inflamación subclínica influencia adversamiente el metabolismo y el pronóstico cardiovascular, pero ingestión elevada de vegetales y frutas há sido pocas veces investigada en este contexto. Objetivo: En un estúdio prospectivo y controlado, el impacto sobre la proteina C-reactiva fue determinado. Metodología: Sesenta pacientes consecutivas sometidas a cirugía cosmética abdominal fueron instruídas a consumir seis porciones diárias de frutas y mais seis de vegetales, en el primero més de postoperatório. Un recordatório alimentar detallado registrado por dietista fue conducido inicialmiente y al cabo del estúdio, con retornos semanales para monitorar aderéncia y cámbios eventuales de la dieta. Análisis de variáncia (ANOVA) y covariáncia (ANCOVA) fueron realizadas para evaluar resultados y minimizar variables de confusión. Conclusiones: Un consumo mas alto de alimientos antioxidantes fue posible, y una respuesta antiinflamatória fue documentada. Estúdios adicionales com suministración y seguimiento mas prolongados son recomendados.

Published
2010

3. Inflamación subclínica en 18,310 donadores de sangre fumadores y no fumadores: la cuenta de leucocitos de sangre periférica como marcador de inflamación.

Author

Vences-Avilés, Marco Aurelio and Gama-Valdez, Lucía

Subjects
*PHYSIOLOGICAL effects of tobacco, *INFLAMMATION, *CARDIOVASCULAR diseases risk factors, *LEUKOCYTE count, *BLOOD donors, *DOSE-response relationship in biochemistry, *PATHOLOGY
Abstract

Background: Smoking has been associated with low-grade systemic inflammation, a known risk factor for cardiovascular disease (CVRF). This state is reflected in elevated white blood cell count (WBC). Objective.: Analyze the relationship between smoking and WBC in blood donors, men and women, of several age groups and analyze the relationship between WBC and others traditional cardiovascular risk factors. Material and methods: Prospective cross-sectional study in 15,601 men and 2,709 women aged between 18 and 65 years. Data analyzed were smoking state and smoking intensity, other cardiovascular risk factors and WBC count. Results: 350 women (12.9%) and 5,091 (32.6%) men were smokers. In both genders, the average count of WBC/mm³ was higher in smokers than in nonsmokers (p = 0.001). WBC remains high in smokers of all age groups, from 18 to 65 years. Analysis of variance showed significant differences in WBC count according to the smoking intensity: nonsmoking versus smoking 1-4 cigarettes/day or ≥ 5 years smoking duration versus smoking ≥ 5 cigarettes/day for ≥ 5 years in men and women (p = 0.001). In bivariate analyses, others traditional cardiovascular risk factors are also associated to increased WBC count. Conclusions: Smoking was associated with elevated WBC, which remains significant in all age groups studied and in both genders. We found that a dose-response relationship exist between smoking intensity and WBC count. [ABSTRACT FROM AUTHOR]

Published
2013

4. Consumption of fruits and vegetables and C - reactive protein in women undergoing cosmetic surgery.

Author

Lima, R. L. F. C., Costa, M. J. C., Filizola, R. G., Asciutti, L. S. R., Leite, R. F., Ferreira, A. S. M., and Faintuch, J.

Subjects
*WOMEN patients, *C-reactive protein, *INFLAMMATION, *FRUIT, *VEGETABLES, *WOMEN'S health, *PHYSIOLOGY, *THERAPEUTICS
Abstract

Low-grade inflammation adversely influences metabolism and cardiovascular prognosis, nevertheless increased intake of fruits and vegetables has rarely been studied in this context. Objective: In a prospective controlled study, the effect on C-reactive protein (CRP) levels was assessed. Methodology: Sixty consecutive women undergoing cosmetic abdominal surgery were instructed to consume six servings each of fruits and vegetables during the first postoperative month. Detailed 24h interviewer-administered dietary recall was conducted at baseline and at the end of the study, with weekly returns to monitor unscheduled dietary changes and compliance with the protocol. Variance (ANOVA) and covariance (ANCOVA) were evaluated to confirm significance and minimize confounding variables. Results: No differences concerning age (42.2 ± 5.3 vs 41.1 ± 6.0 years) or BMI (25.5± 3.1 vs 25.0± 3.0 kg/m²) occurred. Ingestion of fruits increased to approximately 5.2 vs 3.9 and of vegetables 5.9 vs 3.4 servings/ day, respectively. CRP decreased more conspicuously in the treated group (P=0.028), and correlation between vitamin C input and CRP in supplemented participants was demonstrated (P=0.014). Conclusions: Higher intake of antioxidant foods was feasible, and an antiinflammatory effect occurred. Further studies with longer administration and followup period are recommended. [ABSTRACT FROM AUTHOR]

Published
2010
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5. Estado proinflamatorio en niños obesos

Author

Luciardi, M. C., Carrizo, T. R., Díaz, E. I., Áleman, M. N., Bazán, M. C., and Abregu, A. V.

Subjects
PCR-us, TNF-a, TNF-Α, factores proinflama torios, hsPCR, Obesidad, inflamación subclínica, subclinical inflam mation, Obesity
Abstract

Resumen: Introducción: La presencia de un estado de inflamación de bajo grado en niños obesos, se debería, entre otros factores, a que el tejido adiposo de los obesos produce moléculas proinflamatorias que contribuyen al desarrollo de aterosclerosis. Objetivo: Determinar en una población de niños obesos los niveles séricos de ligando CD-40 soluble (sCD40L), proteína quimioatractante de monocitos 1 (MCP-1), interleuquina 6 (IL-6), Factor de Necrosis tumoral a (TNF-a) y Proteína C Reactiva ul trasensible (PCR-us), comparados con un grupo control y analizar la correlación de estas moléculas con las variables antropométricas y metabólicas. Pacientes y Método: Estudio transversal de 37 niños obesos de 8 a 12 años y 20 niños con peso normal. A todos los pacientes se les realizó una historia clí nica consignando edad, peso, talla, IMC, circunferencia de cintura, estadios de Tanner y antecedentes familiares. Se determinaron los niveles séricos de sCD40L, MCP-1, IL-6, TNF-a y PCR-us mediante ELISA, PCR-us por quimioluminiscencia, glucemia, insulina plasmática, perfil lipídico y se calculó el índice HOMA. Los datos se expresaron como la mediana y rango intercuartil y se utilizó el coeficiente de Spearman para investigar las correlaciones entre variables. Resultados: Los niños obesos presen taron valores significativamente mayores de sCD40L, MCP-1, IL-6, TNF-a, PCR-us que los niños controles. El índice de masa corporal y la circunferencia de cintura se correlacionaron positivamente con sCD40L y MCP-1. Conclusión: Los niveles elevados de las moléculas estudiadas sugieren la pre sencia de inflamación de bajo grado asociada a obesidad en esta población. Abstract: Introduction: Obesity is a chronic disease that affects adults as well as children and is associated with insulin resistance, type 2 diabetes and cardiovascular disease. One of the reasons for the presence of low-grade inflammation in these patients could be that adipose tissue of the obese produces proin flammatory molecules that favor the development of atherosclerosis. Objective: To determine serum levels of soluble CD40 ligand (sCD40L), monocyte chemoattractant protein 1 (MCP-1), interleukin 6 (IL-6), Tumor Necrosis Factor alpha (TNF-Α) and high sensitivity CRP (hsCRP), in an obese chil dren population compared to a control group, also to analyze the correlation of these molecules with the anthropometric and metabolic variables. Patients and Method: A cross-sectional, observational study was carried out on 37 obese children, aged 8 to 12 years, and 20 children with normal weight. Serum levels of sCD40L, MCP-1, IL-6, TNF-Α and hsCRP were determined. Data were expressed as the median and interquartil range and Spearman coefficient was used to investigate correlations between variables. Results: Compared to the control group, obese children presented significantly higher values of sCD40L, MCP-1, IL-6, TNF-Α, and hsCRP than control group. Body mass index and waist circumference correlated positively with sCD40L and MCP-1. Conclusion: Elevated levels of the studied molecules studied suggest the presence of low-grade inflammation associated with obesity in this population.

Published
2018

6. Estado proinflamatorio en niños obesos

Author

Luciardi,M. C., Carrizo,T. R., Díaz,E. I., Áleman,M. N., Bazán,M. C., and Abregu,A. V.

Subjects
PCR-us, TNF-a, factores proinflama torios, Obesidad, inflamación subclínica
Abstract

Resumen: Introducción: La presencia de un estado de inflamación de bajo grado en niños obesos, se debería, entre otros factores, a que el tejido adiposo de los obesos produce moléculas proinflamatorias que contribuyen al desarrollo de aterosclerosis. Objetivo: Determinar en una población de niños obesos los niveles séricos de ligando CD-40 soluble (sCD40L), proteína quimioatractante de monocitos 1 (MCP-1), interleuquina 6 (IL-6), Factor de Necrosis tumoral a (TNF-a) y Proteína C Reactiva ul trasensible (PCR-us), comparados con un grupo control y analizar la correlación de estas moléculas con las variables antropométricas y metabólicas. Pacientes y Método: Estudio transversal de 37 niños obesos de 8 a 12 años y 20 niños con peso normal. A todos los pacientes se les realizó una historia clí nica consignando edad, peso, talla, IMC, circunferencia de cintura, estadios de Tanner y antecedentes familiares. Se determinaron los niveles séricos de sCD40L, MCP-1, IL-6, TNF-a y PCR-us mediante ELISA, PCR-us por quimioluminiscencia, glucemia, insulina plasmática, perfil lipídico y se calculó el índice HOMA. Los datos se expresaron como la mediana y rango intercuartil y se utilizó el coeficiente de Spearman para investigar las correlaciones entre variables. Resultados: Los niños obesos presen taron valores significativamente mayores de sCD40L, MCP-1, IL-6, TNF-a, PCR-us que los niños controles. El índice de masa corporal y la circunferencia de cintura se correlacionaron positivamente con sCD40L y MCP-1. Conclusión: Los niveles elevados de las moléculas estudiadas sugieren la pre sencia de inflamación de bajo grado asociada a obesidad en esta población.

Published
2018

7. Determinantes prenatales y postnatales tempranos de enfermedades cardiovasculares en el adulto

Author

José-Guillermo Ortega-Ávila

Subjects
epigenética, lcsh:R5-920, inflamación subclínica, resistencia a la insulina, lcsh:Medicine (General), Disfunción endotelial
Abstract

El enfoque tradicional en la prevención de las Enfermedades Crónicas No Transmisibles (ECNT)como las Enfermedades Cardiovasculares (ECVs) se ha centrado en el estudio e intervención defactores de riesgo clásicos (sedentarismo, malnutrición, tabaquismo, obesidad etc) en la etapa adulta, sin embargo actualmente hay suficiente evidencia que permite considerar que el riesgo de desarrollar una ECVs se inicia desde la etapa prenatal y postnatal temprana. Esta susceptibilidad ocurre en periodos de tiempo de alta plasticidad celular frente a factores de riesgo clásicos y no clásicos, que pueden determinar las instauración fisiológica de disfunción endotelial, resistencia a la insulina, inflamación subclínica crónica y modificaciones epigenéticas estables. Por lo tanto, nuevos esfuerzos en prevención y tratamiento de las ECVs deberían tener en cuenta la salud prenatal y postnatal temprana como un primer paso para reducir la morbimortalidad ocasionada por estas patologías. Abstract: The traditional approach in the prevention of Chronic Non-communicable Diseases (NCDs) such as cardiovascular diseases (CVDs) has focused on the study and intervention of classic risk factors (sedentary lifestyle, poor nutrition, smoking, obesity etc.) in adulthood, however currently, there is evidence that suggest that the risk of developing CVD starts since prenatal and early postnatal stage.This susceptibility occurs in periods of high cellular plasticity where the risk factors classical and non-classical can determine the physiological onset of endothelial dysfunction, insulin resistance, chronic subclinical inflammation and stable epigenetic modifications. Therefore, further efforts inprevention and treatment of CVD should consider the prenatal and early postnatal determinants of child health as a first step towards reducing morbidity and mortality caused by these diseases. Key words: Endothelial dysfunction, subclinical inflammation, insulin resistance, epigenetics.

Published
2015

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