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153 results on '"Ingravalle Francesco"'

1. Changes in glial cell activation and extracellular vesicles production precede the onset of disease symptoms in transgenic hSOD1G93A pigs

Author

Golia, Maria Teresa, Frigerio, Roberto, Pucci, Susanna, Sironi, Francesca, Margotta, Cassandra, Pasetto, Laura, Testori, Camilla, Berrone, Elena, Ingravalle, Francesco, Chiari, Marcella, Gori, Alessandro, Duchi, Roberto, Perota, Andrea, Bergamaschi, Luca, D’Angelo, Antonio, Cagnotti, Giulia, Galli, Cesare, Corona, Cristiano, Bonetto, Valentina, Bendotti, Caterina, Cretich, Marina, Colombo, Sara Francesca, and Verderio, Claudia

Published
2024
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2. A relevant long-term impact of the circulation of a potentially contaminated vaccine on the distribution of scrapie in Italy. Results from a retrospective cohort study

Author

Bertolini Silvia, Maurella Cristiana, Bona Cristina, Ingravalle Francesco, Desiato Rosanna, Baioni Elisa, Chiavacci Laura, Caramelli Maria, and Ru Giuseppe

Subjects
Veterinary medicine, SF600-1100
Abstract

Abstract A sudden increase in the incidence of scrapie in Italy in 1997 was subsequently linked to the use of a potentially infected vaccine against contagious agalactia. The relative risk for the exposed farms ranged between 6 and 40. The aim of this study was to assess the long-term impact of exposure to the potentially scrapie-contaminated vaccine on the Italian classical scrapie epidemic. We carried out a retrospective cohort study, fitting mixed-effects Poisson regression models, dividing national geographic areas into exposure categories on the basis of the vaccine circulation levels. We took into account the sensitivity of the surveillance system applied in the different areas. The population attributable fraction (PAF) was used to assess the impact on the total population of farms associated with the effect of circulation of the vaccine. The provinces where the vaccine was more often sold were noted to have a higher level of disease when compared to those provinces where the vaccine was sold less often (incidence rate ratio [IRR]: 2.7; 95% confidence interval [CI]: 1.1-6.5). The population attributable fraction was high (68.4%). Standardization techniques allowed to account for the potential of geographical variability in the sensitivity of the Italian surveillance system. Although the number of the directly exposed farms was limited, an important long-term impact of the vaccine circulation could be quantified in terms of secondary outbreaks likely due to the exchange of animals from directly exposed flocks.

Published
2012
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3. Effect of autolysis on the specificity of bovine spongiform encephalopathy rapid tests

Author

Caramelli Maria, Ingravalle Francesco, Cavarretta Maria C, Manzardo Elsa, Pezzolato Marzia, Varello Katia, Meloni Daniela, and Bozzetta Elena

Subjects
Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Background Routine rapid testing for Bovine Spongiform Encephalopathy (BSE) has highlighted some problems with BSE rapid test performance, the most significant being the number of initially reactive samples and the false positive results on autolyzed tissue. This point is important for BSE active surveillance in risk populations, because tissue autolysis is often unavoidable in routine cases. A robust test suitable for use on field material is therefore needed. To date, very limited information regarding the effect of autolysis on the robustness of rapid tests has been documented; therefore, the National Reference Centre for Animal Encephalopathies (CEA) rapid test laboratory selected 450 autolyzed and negative brain stem samples from fallen stock bovines older than 24 months to assess the specificity of four tests approved for BSE active surveillance: Biorad TeSeE, Enfer TSE version 2.0, Prionics® Check LIA, and IDEXX Herd Check BSE Antigen Kit EIA. The samples were graded according to the degree of autolysis and then dissected into five portions, four of which randomly assigned to processing by rapid tests and one to be available for confirmatory Western blot analysis. Findings The specificity of the four systems was 100% for all three grades of autolysis, while the percentage of initially reactive results was 0.00 (95%CI 0.00-0.82), 0.22 (95%CI 0.006-1.23), 0.44 (95%CI 0.05-1.60), and 0.89 (95%CI 0.24-2.26) for the Biorad TeSeE, the Prionics® Check LIA, the IDEXX Herd Check BSE and the Enfer TSE tests, respectively. No association with the degree of autolysis could be drawn. Conclusions The present study demonstrates that the four rapid tests can be considered well-running diagnostic tools regardless of tissue quality; nevertheless, the number of initial reactive samples reported for some systems must not be underestimated in routine testing. Furthermore the compliance with the reported performance can be guaranteed only when an ongoing high careful batch quality control system is in place.

Published
2010
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4. The prevalence of atypical scrapie in sheep from positive flocks is not higher than in the general sheep population in 11 European countries

Author

Liam Barry, Hautaniemi Maria, Poizat Renaud, Orge Leonor, Thorgeirsdottir Stefania, Ingravalle Francesco, Nöremark Maria, Maurella Cristiana, Fediaevsky Alexandre, Calavas Didier, Ru Giuseppe, and Hopp Petter

Subjects
Veterinary medicine, SF600-1100
Abstract

Abstract Background During the last decade, active surveillance for transmissible spongiform encephalopathies in small ruminants has been intensive in Europe. In many countries this has led to the detection of cases of atypical scrapie which, unlike classical scrapie, might not be contagious. EU legislation requires, that following detection of a scrapie case, control measures including further testing take place in affected flocks, including the culling of genotype susceptible to classical scrapie. This might result in the detection of additional cases. The aim of this study was to investigate the occurrence of additional cases in flocks affected by atypical scrapie using surveillance data collected in Europe in order to ascertain whether atypical scrapie, is contagious. Results Questionnaires were used to collect, at national level, the results of active surveillance and testing associated with flock outbreaks in 12 European countries. The mean prevalence of atypical scrapie was 5.5 (5.0-6.0) cases per ten thousand in abattoir surveillance and 8.1 (7.3-9.0) cases per ten thousand in fallen stock. By using meta-analysis, on 11 out of the 12 countries, we found that the probability of detecting additional cases of atypical scrapie in positive flocks was similar to the probability observed in animals slaughtered for human consumption (odds ratio, OR = 1.07, CI95%: 0.70-1.63) or among fallen stock (OR = 0.78, CI95%: 0.51-1.2). In contrast, when comparing the two scrapie types, the probability of detecting additional cases in classical scrapie positive flocks was significantly higher than the probability of detecting additional cases in atypical scrapie positive flocks (OR = 32.4, CI95%: 20.7-50.7). Conclusions These results suggest that atypical scrapie is not contagious or has a very low transmissibility under natural conditions compared with classical scrapie. Furthermore this study stressed the importance of standardised data collection to make good use of the analyses undertaken by European countries in their efforts to control atypical and classical scrapie.

Published
2010
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8. Brain-Derived Neurotrophic Factor, Kynurenine Pathway, and Lipid-Profiling Alterations as Potential Animal Welfare Indicators in Dairy Cattle

Author

Favole, Alessandra, primary, Testori, Camilla, additional, Bergagna, Stefania, additional, Gennero, Maria Silvia, additional, Ingravalle, Francesco, additional, Costa, Barbara, additional, Barresi, Sara, additional, Curti, Piercarlo, additional, Barberis, Francesco, additional, Ganio, Sandra, additional, Orusa, Riccardo, additional, Vallino Costassa, Elena, additional, Berrone, Elena, additional, Vernè, Marco, additional, Scaglia, Massimo, additional, Palmitessa, Claudia, additional, Gallo, Marina, additional, Tessarolo, Carlotta, additional, Pederiva, Sabina, additional, Ferrari, Alessio, additional, Lorenzi, Valentina, additional, Fusi, Francesca, additional, Brunelli, Laura, additional, Pastorelli, Roberta, additional, Cagnotti, Giulia, additional, Casalone, Cristina, additional, Caramelli, Maria, additional, and Corona, Cristiano, additional

Published
2023
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18. Using network analysis to identify seasonal patterns and key nodes for risk‐based surveillance of pig diseases in Italy

Author

Crescio, Maria Ines, primary, Mastrantonio, Gianluca, additional, Bertolini, Silvia, additional, Maurella, Cristiana, additional, Adkin, Amie, additional, Ingravalle, Francesco, additional, Simons, Robin R. L., additional, DeNardi, Marco, additional, Stark, Katharina, additional, Estrada‐Peña, Agustin, additional, and Ru, Giuseppe, additional

Published
2020
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21. Real-time PCR assay for detecting illicit steroid administration in veal calves allows reliable biomarker profiling of formalin-fixed, paraffin-embedded (FFPE) archival tissue samples

Author

Benedetto, Alessandro, primary, Pezzolato, Marzia, additional, Beltramo, Chiara, additional, Audino, Valentina, additional, Ingravalle, Francesco, additional, Pillitteri, Caterina, additional, Foschini, Stefano, additional, Peletto, Simone, additional, and Bozzetta, Elena, additional

Published
2020
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23. Social network analysis and risk assessment: An example of introducing an exotic animal disease in Italy

Author

Maurella, Cristiana, primary, Mastrantonio, Gianluca, additional, Bertolini, Silvia, additional, Crescio, Maria Ines, additional, Ingravalle, Francesco, additional, Adkin, Amie, additional, Simons, Robin, additional, De Nardi, Marco, additional, Estrada-Peña, Augustin, additional, Horigan, Verity, additional, and Ru, Giuseppe, additional

Published
2019
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24. Using network analysis to identify seasonal patterns and key nodes for risk‐based surveillance of pig diseases in Italy.

Author

Crescio, Maria Ines, Mastrantonio, Gianluca, Bertolini, Silvia, Maurella, Cristiana, Adkin, Amie, Ingravalle, Francesco, Simons, Robin R. L., DeNardi, Marco, Stark, Katharina, Estrada‐Peña, Agustin, and Ru, Giuseppe

Subjects
SEASONS, SWINE, INFECTIOUS disease transmission, SOCIAL network analysis, SEXUAL cycle, ANIMAL herds, SWINE growth
Abstract

The description of the pattern of livestock movements between herds provides essential information for both improving risk‐based surveillance and to understand the likely spread of infectious diseases. This study provides a description of the temporal pattern of pig movements recorded in Italy on a 4‐year period (2013–2016). Data, provided by the National Livestock registry, were described by social network analysis and the application of a walk‐trap algorithm for community detection. Our results show a highly populated community located in Northern Italy, which is the focal point of the Italian industrial pig production and as a general pattern an overall decline of medium and backyard farms and an increase in the number of large farms, in agreement with the trend observed by other EU pig‐producing countries. A seasonal pattern of all the parameters evaluated, including the number of active nodes in both the intensive and smaller production systems, emerged: that is characterized by a higher number of movements in spring and autumn, linked with the breeding and production cycle as pigs moved from the growing to the finishing phase and with periods of increased slaughtering at Christmas and Easter. The same pattern was found when restricting the analysis to imported pig batches. Outbreaks occurring during these periods would have a greater impact on the spread of infectious diseases; therefore, targeted surveillance may be appropriate. Finally, potential super‐spreader nodes have been identified and represent 0.47% of the total number of pig holdings (n = 477). Those nodes are present during the whole study period with a similar ranking in their potential of being super‐spreaders. Most of them were in Northern Italy, but super‐spreaders with high mean out‐degree centrality were also located in other Regions. Seasonality, communities and super‐spreaders should be considered when planning surveillance activity and when applying disease control strategies. [ABSTRACT FROM AUTHOR]

Published
2021
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25. MOESM5 of Predicting the impact of selection for scrapie resistance on PRNP genotype frequencies in goats

Author

Sacchi, Paola, Rasero, Roberto, Ru, Giuseppe, Aiassa, Eleonora, Colussi, Silvia, Ingravalle, Francesco, Peletto, Simone, Perrotta, Maria, Sartore, Stefano, Soglia, Dominga, and Acutis, Pierluigi

Subjects
animal diseases
Abstract

Additional file 5. SchemeB1 (i.e. only a closed-nucleus provided genotyped candidates for its own replacement and for the base herds; selection was performed without time limits). Effects on base herds over years after the beginning of selection accounting for different patterns of age structure.

Published
2018
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27. GR CALUX assay detects synthetic glucocorticoids in calf urine: a validation study

Author

Pitardi, Danilo, primary, Meloni, Daniela, additional, Olivo, Fabio, additional, Loprevite, Daniela, additional, Cavarretta, Maria C., additional, Behnisch, Peter, additional, Brouwer, Abraham, additional, Felzel, Emiel, additional, Ingravalle, Francesco, additional, Capra, Pierluigi, additional, Gili, Marilena, additional, Pezzolato, Marzia, additional, and Bozzetta, Elena, additional

Published
2019
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29. Low fraction of the 222K PrP variant in the protease-resistant moiety of PrPres in heterozygous scrapie positive goats

Author

Mazza, M., Guglielmetti, Chiara, Ingravalle, Francesco, Brusadore, Sonia, Langeveld, J.P.M., Ekateriniadou, Loukia V., Andreoletti, O., Casalone, C., Acutis, P.L., Mazza, M., Guglielmetti, Chiara, Ingravalle, Francesco, Brusadore, Sonia, Langeveld, J.P.M., Ekateriniadou, Loukia V., Andreoletti, O., Casalone, C., and Acutis, P.L.

Abstract

The presence of lysine (K) at codon 222 has been associated with resistance to classical scrapie in goats, but few scrapie cases have been identified in 222Q/K animals. To investigate the contribution of the 222K variant to PrPres formation in natural and experimental Q/K scrapie cases, we applied an immunoblotting method based on the use of two different monoclonal antibodies, F99/97.6.1 and SAF84, chosen for their different affinities to 222K and 222Q PrP variants. Our finding that PrPres seems to be formed nearly totally by the 222Q variant provides evidence that the 222K PrP variant confers resistance to conversion to PrPres formation and reinforces the view that this mutation has a protective role against classical scrapie in goats.

Published
2017

30. Rapid tests might overlook bovine spongiform encephalopathy infection in goats

Author

Meloni, Daniela, Bozzetta, Elena, Lageveld, Jan P. M., Groschup, Martin H., Goldmann, Wilfred, Andreoletti, Olivier, Lantier, Isabelle, Keulen, Lucien, Alex Bossers, Nonno, Romolo, Ingravalle, Francesco, Manzardo, Elsa, Cavarretta, Maria C., Loprevite, Daniela, Acutis, Pier Luigi, Istituto Zooprofilattico Sperimentale del Piemonte, Wageningen University and Research Centre (WUR), Friedrich-Loeffler-Institut (FLI), R(D)SVS, Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Istituto Superiore di Sanità, National Center Hospital. JPN., and Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016
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31. Lipophilic marine toxins: Evaluation of rapid tests for their rapid detection

Author

Francese, Danila Raffaella, primary, Varello, Katia, additional, Ciccotelli, Valentina, additional, Sosa, Silvio, additional, Cavarretta, Maria Concetta, additional, Ingravalle, Francesco, additional, Meloni, Daniela, additional, Vivaldi, Barbara, additional, Ceccarelli, Lara, additional, Tubaro, Aurelia, additional, and Bozzetta, Elena, additional

Published
2017
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34. EU-approved rapid tests might underestimate bovine spongiform encephalopathy infection in goats

Author

Meloni, Daniela, primary, Bozzetta, Elena, additional, Langeveld, Jan P. M., additional, Groschup, Martin H., additional, Goldmann, Wilfred, additional, Andrèoletti, Olivier, additional, Lantier, Isabelle, additional, Van Keulen, Lucien, additional, Bossers, Alex, additional, Pitardi, Danilo, additional, Nonno, Romolo, additional, Sklaviadis, Theodoros, additional, Ingravalle, Francesco, additional, Peletto, Simone, additional, Colussi, Silvia, additional, and Acutis, Pier Luigi, additional

Published
2017
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35. A biochemical approach to evaluate the contribution to pathological prion protein formation from the 222K PrP variant in scrapie positive goats

Author

Mazza, Maria, Guglielmetti, Chiara, Ingravalle, Francesco, Langeveld, Jan P. M., Ekateriniadou, Loukia V., Andréoletti, Olivier, Acutis, Pier Luigi, Istituto Zooprofilattico Sperimentale del Piemonte, Wageningen University and Research Centre (WUR), Veterinary Research Institute of Thessaloniki, National Agricultural Research Foundation (NAGREF), Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

37. Transmissible Spongiform Encephalopathies rapid post mortem tests in goats: Strategies to improve the efficiency of the active surveillance statutory programme

Author

Meloni, Daniela, Bozzetta, Elena, Langeveld, Jan P. M., Groschup, Martin H., Goldmann, Wilfred, Andreoletti, Olivier, Lantier, Isabelle, Keulen, Lucien J. M., Alex Bossers, Manzardo, Elsa, Cavarretta, Maria C., Loprevite, Daniela, Perrotta, Maria Gabriella, Pitardi, Danilo, Ingravalle, Francesco, Peletto, Simone, Colussi, Silvia, Acutis, Pier Luigi, Istituto Zooprofilattico Sperimentale del Piemonte, Wageningen University and Research Centre (WUR), Federal Research Institute for Animal Health, Friedrich Löffler Institute - Institute of Diagnostic Virology, R(D)SVS, Interactions hôtes-agents pathogènes [Toulouse] (IHAP), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Ministero della Salute, Partenaires INRAE, and Institut National de la Recherche Agronomique (INRA)-Université de Tours

Subjects
[SDV]Life Sciences [q-bio], encéphalite spongiforme, caprin, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014
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39. Antipsichiatria.

Author

INGRAVALLE, FRANCESCO and CARENA, TIZIANA C.

Abstract

The article reports on the reality of a concept of antipsychiatry. It is said that the ideological current that provided the general basis for antipsychiatry was relativism: both that particular normative relativism that the anthropological-cultural school had popularized in the West, or a more philosophical relativism.

Published
2018

43. Pilot project to set up a control programme on fishery products

Author

Richelmi, Guia Benedetta, primary, Pezzolato, Marzia, additional, Gili, Stefano, additional, Gallina, Silvia, additional, Decastelli, Lucia, additional, Tarasco, Renata, additional, Abete, Maria Cesarina, additional, Ingravalle, Francesco, additional, Serracca, Laura, additional, Pavino, Davide, additional, Vivaldi, Barbara, additional, Riina, Maria Vittoria, additional, Acutis, Pier Luigi, additional, Prearo, Marino, additional, Caramelli, Maria, additional, and Bozzetta, Elena, additional

Published
2013
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48. The prevalence of atypical scrapie in sheep from positive flocks is not higher than in the general sheep population in 11 European countries

Author

Fediaevsky, Alexandre, primary, Maurella, Cristiana, additional, Nöremark, Maria, additional, Ingravalle, Francesco, additional, Thorgeirsdottir, Stefania, additional, Orge, Leonor, additional, Poizat, Renaud, additional, Hautaniemi, Maria, additional, Liam, Barry, additional, Calavas, Didier, additional, Ru, Giuseppe, additional, and Hopp, Petter, additional

Published
2010
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50. European Interlaboratory Trial Regarding the Official Microscopic Method for the Detection of the Presence of Animal Constituents in Feedstuffs

Author

Lai, Jeanne, primary, Ru, Giuseppe, additional, Ingravalle, Francesco, additional, Choiseul, James, additional, Jørgensen, Jan Sten, additional, Peña Millan, Maria B., additional, Vancutsem, Jeroen, additional, Wernitznig, Franz, additional, Marchis, Daniela, additional, and Decastelli, Lucia, additional

Published
2008
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