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2. Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial

Author

Saraste, Antti, Ballo, Haitham, Arola, Olli, Laitio, Ruut, Airaksinen, Juhani, Hynninen, Marja, Bäcklund, Minna, Ylikoski, Emmi, Wennervirta, Johanna, Pietilä, Mikko, Roine, Risto O, Harjola, Veli-Pekka, Niiranen, Jussi, Korpi, Kirsi, Varpula, Marjut, Scheinin, Harry, Maze, Mervyn, Vahlberg, Tero, Laitio, Timo, Virtanen, Sami, Parkkola, Riitta, Saunavaara, Jani, Martola, Juha, Silvennoinen, Heli, Tiainen, Marjaana, Grönlund, Juha, Inkinen, Outi, Silvasti, Päivi, Nukarinen, Eija, and Olkkola, Klaus T

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Cardiovascular, Clinical Research, Heart Disease, Clinical Trials and Supportive Activities, cardiac arrest, cardiac function, cardioprotection, echocardiography, ejection fraction, myocardial strain, Clinical sciences
Abstract

This explorative substudy aimed at determining the effect of inhaled xenon on left ventricular function by echocardiography in comatose survivors of out-of-hospital cardiac arrest.DesignA randomized two-group single-blinded phase 2 clinical drug trial.SettingA multipurpose ICU in two university hospitals.PatientsOf the 110 randomized comatose survivors after out-of-hospital cardiac arrest with a shockable rhythm in the xenon in combination with hypothermia after cardiac arrest trial, 38 patients (24-76 yr old) with complete echocardiography were included in this study.InterventionsPatients were randomized to receive either inhaled xenon combined with hypothermia (33°C) for 24 hours or hypothermia treatment alone. Echocardiography was performed at hospital admission and 24 ± 4 hours after hypothermia.Measurements and main resultsLeft ventricular ejection fraction, myocardial longitudinal systolic strain, and diastolic function were analyzed blinded to treatment. There were 17 xenon and 21 control patients in whom echocardiography was completed. Clinical characteristics did not differ significantly between the groups. At admission, ejection fraction was similar in xenon and control patients (39% ± 10% vs 38% ± 11%; p = 0.711) but higher in xenon than control patients after hypothermia (50% ± 10% vs 42% ± 10%; p = 0.014). Global longitudinal systolic strain was similar in xenon and control patients at admission (-9.0% ± 3.8% vs -8.1% ± 3.6%; p = 0.555) but better in xenon than control patients after hypothermia (-14.4.0% ± 4.0% vs -10.5% ± 4.0%; p = 0.006). In patients with coronary artery disease, longitudinal strain improved in the nonischemic myocardial segments in xenon patients. There were no changes in diastolic function between the groups.ConclusionsAmong comatose survivors of a cardiac cause out-of-hospital cardiac arrest, inhaled xenon combined with hypothermia was associated with greater recovery of left ventricular systolic function in comparison with hypothermia alone.

Published
2021

3. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis

Author

Vaara, Suvi T., Serpa Neto, Ary, Bellomo, Rinaldo, Adhikari, Neill K. J., Dreyfuss, Didier, Gallagher, Martin, Gaudry, Stephane, Hoste, Eric, Joannidis, Michael, Pettilä, Ville, Wang, Amanda Y., Kashani, Kianoush, Wald, Ron, Bagshaw, Sean M., Ostermann, Marlies, Bagshaw, Sean M, Wald, Ron, Adhikari, Neill K.J., Bellomo, Rinaldo, Dreyfuss, Didier, Du, Bin, Gallagher, Martin P., Gaudry, Stéphane, Hoste, Eric A., Lamontagne, François, Joannidis, Michael, Liu, Kathleen D., McAuley, Daniel F., McGuinness, Shay P., Nichol, Alistair D., Ostermann, Marlies, Palevsky, Paul M., Qiu, Haibo, Pettilä, Ville, Schneider, Antoine G., Smith, Orla M., Vaara, Suvi T., Weir, Matthew, Bellomo, Rinaldo, Eastwood, Glenn M., Peck, Leah, Young, Helen, Kruger, Peter, Laurie, Gordon, Saylor, Emma, Meyer, Jason, Venz, Ellen, Wetzig, Krista, French, Craig, McGain, Forbes, Mulder, John, Fennessy, Gerard, Koottayi, Sathyajith, Bates, Samantha, Towns, Miriam, Morgan, Rebecca, Tippett, Anna, Udy, Andrew, Mason, Chris, Licari, Elisa, Gantner, Dashiell, McClure, Jason, Nichol, Alistair, McCracken, Phoebe, Board, Jasmin, Martin, Emma, Vallance, Shirley, Young, Meredith, Vladic, Chelsey, McGloughlin, Steve, Gattas, David, Buhr, Heidi, Coles, Jennifer, Hutch, Debra, Wun, James, Cole, Louise, Whitehead, Christina, Lowrey, Julie, Masters, Kristy, Gresham, Rebecca, Campbell, Victoria, Gutierrez, David, Brailsford, Jane, Forbes, Loretta, Murray, Lauren, Maguire, Teena, NiChonghaile, Martina, Orford, Neil, Bone, Allison, Elderkin, Tania, Salerno, Tania, Chimunda, Tim, Fletcher, Jason, Broadfield, Emma, Porwal, Sanjay, Knott, Cameron, Boschert, Catherine, Smith, Julie, Richardson, Angus, Hill, Dianne, Duke, Graeme, Oziemski, Peter, Cegarra, Santiago, Chan, Peter, Welsh, Deborah, Hunter, Stephanie, Roodenburg, Owen, Dyett, John, Kokotsis, Nicos, Moser, Max, Yang, Yang, Padayachee, Laven, Vetro, Joseph, Gangopadhyay, Himangsu, Kaufman, Melissa, Ghosh, Angaj, Said, Simone, Patel, Alpesh, Bihari, Shailesh, Matheson, Elisha, Jin, Xia, Shrestha, Tapaswi, Schwartz, Kate, Gallagher, Martin P., Cross, Rosalba, Cheung, Winston, Wong, Helen, Kol, Mark, Shah, Asim, Wang, Amanda Y., Endre, Zoltan, Bradford, Celia, Janin, Pierre, Finfer, Simon, Diel, Naomi, Gatward, Jonathan, Hammond, Naomi, Delaney, Anthony, Bass, Frances, Yarad, Elizabeth, Buscher, Hergen, Reynolds, Claire, Baker, Nerilee, Joannidis, Michael, Bellmann, Romuald, Peer, Andreas, Hasslacher, Julia, Koglberger, Paul, Klein, Sebastian, Zotter, Klemens, Brandtner, Anna, Finkenstedt, Armin, Ditlbacher, Adelheid, Hartig, Frank, Fries, Dietmar, Bachler, Mirjam, Schenk, Bettina, Wagner, Martin, Staudinger, Thomas, Tiller, Esther, Schellongowski, Peter, Bojic, Andja, Hoste, Eric A., Bracke, Stephanie, De Crop, Luc, Vermeiren, Daisy, Thome, Fernando, Chiella, Bianca, Fendt, Lucia, Antunes, Veronica, Maisonneuve-Rosemont, Lafrance, Jean-Philippe, Lamontagne, François, D’Aragon, Frédérick, St-Arnaud, Charles, Mayette, Michael, Carbonnaeu, Élaine, Marchand, Joannie, Masse, Marie-Hélène, Ladouceur, Marilène, Turgeon, Alexis F., Lauzier, François, Bellemare, David, Langis Francoeur, Charles, LeBlanc, Guillaume, Guilbault, Gabrielle, Grenier, Stéphanie, Cloutier, Eve, Boivin, Annick, Delisle-Thibault, Charles, Giannakouros, Panagiota, Costerousse, Olivier, Cailhier, Jean-François, Carrier, François-Martin, Ghamraoui, Ali, Lebrasseur, Martine, Benettaib, Fatna, Salamé, Maya, Boumahni, Dounia, Tung Sia, Ying, Naud, Jean-François, Roy, Isabelle, Stelfox, Henry T., Ruddell, Stacey, Manns, Braden J., Duggan, Shelley, Carney, Dominic, Barchard, Jennifer, Whitlock, Richard P., Belley-Cote, Emilie, Savija, Nevena, Sabev, Alexandra, Campbell, Troy, Creary, Thais, Devereaux, Kelson, Brodutch, Shira, Rigatto, Claudio, Paunovic, Bojan, Mooney, Owen, Glybina, Anna, Harasemiw, Oksana, Di Nella, Michelle, Harmon, John, Mehta, Navdeep, Lakatos, Louis, Haslam, Nicole, Lellouche, Francois, Simon, Mathieu, Tung, Ying, Lizotte, Patricia, Bourchard, Pierre-Alexandre, Rochwerg, Bram, Karachi, Tim, Millen, Tina, Muscedere, John, Maslove, David, Gordon Boyd, J., Sibley, Stephanie, Drover, John, Hunt, Miranda, Georgescu, Ilinca, Wax, Randy, Lenga, Ilan, Sridhar, Kavita, Steele, Andrew, Fusco, Kelly, Ghate, Taneera, Tolibas, Michael, Robinson, Holly, Weir, Matthew A., Taneja, Ravi, Ball, Ian M., Garg, Amit, Campbell, Eileen, Ovsenek, Athena, Bagshaw, Sean M., van Diepen, Sean, Baig, Nadia, Magder, Sheldon, Yao, Han, Alam, Ahsan, Campisi, Josie, MacIntyre, Erika, Rokosh, Ella, Scherr, Kimberly, Lapinsky, Stephen, Mehta, Sangeeta, Shah, Sumesh, Niven, Daniel J., Stelfox, Henry T., Ruddell, Stacey, Russell, Michael, Jim, Kym, Brown, Gillian, Oxtoby, Kerry, Hall, Adam, Benoit, Luc, Sokolowski, Colleen, Prasad, Bhanu, Rao, Jag, Giebel, Shelley, Kutsogiannis, Demetrios J., Thompson, Patricia, Thompson, Tayne, Cirone, Robert, Kavikondala, Kanthi, Soth, Mark, Clarke, France, Takaoka, Alyson, Wald, Ron, Mazer, David, Burns, Karen, Friedrich, Jan, Klein, David, Sandhu, Gyan, Santos, Marlene, Khalid, Imrana, Hodder, Jennifer, Dodek, Peter, Ayas, Najib, Alcuaz, Victoria, Suen, Gabriel, Rewa, Oleksa, Singh, Gurmeet, Norris, Sean, Gibson, Neil, Arias, Castro, Shami, Aysha, Pelletier, Celine, Adhikari, Neill K.J., Zahirieh, Alireza, Amaral, Andre, Marinoff, Nicole, Kaur, Navjot, Perez, Adic, Wang, Jane, Haljan, Gregory, Condin, Christopher, McIntyre, Lauralyn, Gomes, Brigette, Porteous, Rebecca, Watpool, Irene, Hiremath, Swapnil, Clark, Edward, Herridge, Margaret S., Backhouse, Felicity, Elizabeth Wilcox, M., Walczak, Karolina, Ki, Vincent, Sharman, Asheer, Romano, Martin, Bagshaw, Sean M., Noel Gibney, R.T., Romanovsky, Adam S., Rewa, Oleksa, McCoshen, Lorena, Baig, Nadia, Wood, Gordon, Ovakim, Daniel, Auld, Fiona, Carney, Gayle, Duan, Meili, Ji, Xiaojun, Guo, Dongchen, Qi, Zhili, Lin, Jin, Zhang, Meng, Dong, Lei, Liu, Jingfeng, Liu, Pei, Zhi, Deyuan, Bai, Guoqiang, Qiu, Yu, Yang, Ziqi, Bai, Jing, Liu, Zhuang, Zhuang, Haizhou, Wang, Haiman, Li, Jian, Zhao, Mengya, Zhou, Xiao, Shi, Xianqing, Ye, Baning, Liu, Manli, Wu, Jing, Fu, Yongjian, Long, Dali, Pan, Yu, Wang, Jinlong, Mei, Huaxian, Zhang, Songsong, Wen, Mingxiang, Yang, Enyu, Mu, Sijie, Li, Jianquan, Hu, Tingting, Qin, Bingyu, Li, Min, Wang, Cunzhen, Dong, Xin, Wang, Kaiwu, Wang, Haibo, Yang, Jianxu, Du, Bin, Wang, Chuanyao, Wang, Dongxin, Li, Nan, Yu, Zhui, Xu, Song, Yao, Lan, Hou, Guo, Liu, Zhou, Lu, Liping, Lian, Yingtao, Wang, Chunting, Zhang, Jichen, Ding, Ruiqi, Qi, Guoqing, Wang, Qizhi, Wang, Peng, Meng, Zhaoli, Chen, Man, Hu, Xiaobo, He, Xiandi, Zhao, Shibing, Hang, Lele, Li, Rui, Qin, Suhui, Lu, Kun, Dun, Shijuan, Liu, Cheng, Zhou, Qi, Chen, Zhenzhen, Mei, Jing, Zhang, Minwei, Xu, Hao, Lin, Jincan, Shi, Qindong, Fu, Lijuan, Zeng, Qinjing, Ma, Hongye, Yan, Jinqi, Gao, Lan, Liu, Hongjuan, Zhang, Lei, Li, Hao, He, Xiaona, Fan, Jingqun, Guo, Litao, Liu, Yu, Wang, Xue, Sun, Jingjing, Liu, Zhongmin, Yang, Juan, Ding, Lili, Sheng, Lulu, Liu, Xingang, Yan, Jie, Wang, Quihui, Wang, Yifeng, Zhao, Dan, Zhao, Shuangping, Hu, Chenghuan, Li, Jing, Deng, Fuxing, Qiu, Haibo, Yang, Yi, Mo, Min, Pan, Chun, Wu, Changde, Huang, Yingzi, Huang, Lili, Liu, Airan, Pettilä, Ville, Vaara, Suvi T., Korhonen, Anna-Maija, Törnblom, Sanna, Sutinen, Sari, Pettilä, Leena, Heinonen, Jonna, Lappi, Eliria, Suhonen, Taria, Karlsson, Sari, Hoppu, Sanna, Jalkanen, Ville, Kuitunen, Anne, Levoranta, Markus, Långsjö, Jaakko, Ristimäki, Sanna, Malila, Kaisa, Wootten, Anna, Varila, Simo, Järvisalo, Mikko J, Inkinen, Outi, Kentala, Satu, Leivo, Keijo, Haltia, Paivi, Dreyfuss, Didier, Ricard, Jean-Damien, Messika, Jonathan, Tiagarajah, Abirami, Emery, Malo, Dechanet, Aline, Gernez, Coralie, Roux, Damien, Martin-Lefevre, Laurent, Fiancette, Maud, Vinatier, Isabelle, Claude Lacherade, Jean, Colin, Gwenhaël, Lebert, Christine, Azais, Marie-Ange, Yehia, Aihem, Pouplet, Caroline, Henry- Lagarrigue, Matthieu, Seguin, Amélie, Crosby, Laura, Maizel, Julien, Titeca-Beauport, Dimitri, Combes, Alain, Nieszkowska, Ania, Masi, Paul, Demoule, Alexandre, Mayaux, Julien, Dres, Martin, Morawiec, Elise, Decalvele, Maxens, Demiri, Suela, Faure, Morgane, Marios, Clémence, Mallet, Maxime, Amélie Ordon, Marie, Morizot, Laura, Cantien, Marie, Pousset, François, Gaudry, Stéphane, Poirson, Florent, Cohen, Yves, Argaud, Laurent, Cour, Martin, Bitker, Laurent, Simon, Marie, Hernu, Romain, Baudry, Thomas, De La Salle, Sylvie, Robine, Adrien, Sedillot, Nicholas, Tchenio, Xavier, Bouisse, Camille, Roux, Sylvie, Barbar, Davide, Trusson, Rémi, Tamion, Fabienne, Grangé, Steven, Carpentier, Dorothée, Chevrel, Guillaume, Ensenyat-Martin, Luis, Marque, Sophie, Quenot, Jean-Pierre, Andreu, Pascal, Dargent, Auguste, Large, Audrey, Chudeau, Nicolas, Landais, Mickael, Derrien, Benoit, Christophe Callahan, Jean, Guitton, Christophe, Le Moal, Charlène, Robert, Alain, Asehnoune, Karim, Cinotti, Raphaël, Grillot, Nicolas, Demeure, Dominique, Vinsonneau, Christophe, Rahmani, Imen, Marzouk, Mehdi, Dekeyser, Thibault, Sejourne, Caroline, Verlay, Mélanie, Thevenin, Fabienne, Delecolle, Lucie, Didier Thevenin, Lens, Souweine, Bertrand, Coupez, Elisabeth, Adda, Mireille, Eraldi, Jean-Pierre, Marchalot, Antoine, De Prost, Nicolas, Mekontso Dessap, Armand, Razazi, Keyvan, Meziani, Ferhat, Boisrame-Helms, Julie, Clere-Jehl, Raphael, Delabranche, Xavier, Kummerlen, Christine, Merdji, Hamid, Monnier, Alexandra, Rabouel, Yannick, Rahmani, Hassene, Allam, Hayat, Chenaf, Samir, Franja, Vincenta, Pons, Bertrand, Carles, Michel, Martino, Frédéric, Richard, Régine, Zuber, Benjamin, Lacave, Guillaume, Lakhal, Karim, Rozec, Bertrand, Dang Van, Hoa, Boulet, Éric, Dubos, René, Fadel, Fouad, Cleophax, Cedric, Dufour, Nicolas, Grant, Caroline, Thuong, Marie, Reignier, Jean, Canet, Emmanuel, Nicolet, Laurent, Boulain, Thierry, Nay, Mai-Anh, Benzekri, Dalila, Barbier, François, Bretagnol, Anne, Kamel, Toufik, Mathonnet, Armelle, Muller, Grégoire, Skarzynski, Marie, Rossi, Julie, Pradet, Amandine, Dos Santos, Sandra, Guery, Aurore, Muller, Lucie, Felix, Luis, Bohé, Julien, Thiéry, Guillaume, Aissaoui, Nadia, Vimpere, Damien, Commeureuc, Morgane, Diehl, Jean-Luc, Guerot, Emmanuel, Liangos, Orfeas, Wittig, Monika, Zarbock, Alexander, Küllmar, Mira, van Waegeningh, Thomas, Rosenow, Nadine, Nichol, Alistair D., Brickell, Kathy, Doran, Peter, Murray, Patrick T., Landoni, Giovanni, Lembo, Rosalba, Zangrillo, Alberto, Monti, Giacomo, Tozzi, Margherita, Marzaroli, Matteo, Lombardi, Gaetano, Paternoster, Gianluca, Vitiello, Michelangelo, McGuinness, Shay, Parke, Rachael, Butler, Magdalena, Gilder, Eileen, Cowdrey, Keri-Anne, Wallace, Samantha, Hallion, Jane, Woolett, Melissa, Neal, Philippa, Duffy, Karina, Long, Stephanie, McArthur, Colin, Simmonds, Catherine, Chen, Yan, McConnochie, Rachael, Newby, Lynette, Knight, David, Henderson, Seton, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Vander Hayden, Kymbalee, Burke, Tara, Bailey, Matthew, Freebairn, Ross, Chadwick, Lesley, Park, Penelope, Rolls, Christine, Thomas, Liz, Buehner, Ulrike, Williams, Erin, Albrett, Jonathan, Kirkham, Simon, Jackson, Carolyn, Browne, Troy, Goodson, Jennifer, Jackson, David, Houghton, James, Callender, Owen, Higson, Vicki, Keet, Owen, Dominy, Clive, Young, Paul, Hunt, Anna, Judd, Harriet, Lawrence, Cassie, Olatunji, Shaanti, Robertson, Yvonne, Latimer-Bell, Charlotte, Hendry, Deborah, Mckay-Vucago, Agnes, Beehre, Nina, Lesona, Eden, Navarra, Leanlove, Robinson, Chelsea, Jang, Ryan, Junge, Andrea, Lambert, Bridget, Schneider, Antoine G., Thibault, Michel, Eckert, Philippe, Kissling, Sébastien, Polychronopoulos, Erietta, Poli, Elettra, Altarelli, Marco, Schnorf, Madeleine, Abed Mallaird, Samia, Heidegger, Claudia, Perret, Aurelie, Montillier, Philippe, Sangla, Frederic, Neils, Seigenthaller, De Watteville, Aude, Phull, Mandeep-Kaur, George, Aparna, Hussain, Nauman, Pogreban, Tatiana, Lobaz, Steve, Daniels, Alison, Cunningham, Mishell, Kerr, Deborah, Nicholson, Alice, Shanmugasundaram, Pradeep, Abrams, Judith, Manso, Katarina, Hambrook, Geraldine, McKerrow, Elizabeth, Salva, Juvy, Foulkes, Stephen, Wise, Matthew, Morgan, Matt, Brooks, Jenny, Cole, Jade, Michelle Davies, Tracy, Hill, Helen, Thomas, Emma, Vizcaychipi, Marcela, Baharlo, Behrad, Carungcong, Jaime, Costa, Patricia, Martins, Laura, Kapoor, Ritoo, Hazelton, Tracy, Moon, Angela, Musselwhite, Janine, Shelley, Ben, McCall, Philip, Ostermann, Marlies, Arbane, Gill, Bociek, Aneta, Marotti, Martina, Lim, Rosario, Campos, Sara, Grau Novellas, Neus, Cennamo, Armando, Slack, Andrew, Wyncoll, Duncan, Camporota, Luigi, Sparkes, Simon, Tilley, Rosalinde, Rattray, Austin, Moreland, Gayle, Duffy, Jane, McGonigal, Elizabeth, Hopkins, Philip, Finney, Clare, Smith, John, Noble, Harriet, Watson, Hayley, Harris, Claire-Louise, Clarey, Emma, Corcoran, Eleanor, Beck, James, Howcroft, Clare, Youngs, Nora, Wilby, Elizabeth, Ogg, Bethan, Wolverson, Adam, Lee, Sandra, Butler, Susie, Okubanjo, Maryanne, Hindle, Julia, Welters, Ingeborg, Williams, Karen, Johnson, Emily, Patrick-Heselton, Julie, Shaw, David, Waugh, Victoria, Stewart, Richard, Mwaura, Esther, Wren, Lynn, Mew, Louise, Sutherland, Sara-Beth, Adderley, Jane, Ruddy, Jim, Harkins, Margaret, Kaye, Callum, Scott, Teresa, Mitchell, Wendy, Anderson, Felicity, Willox, Fiona, Jagannathan, Vijay, Clark, Michele, Purv, Sarah, Sharman, Andrew, Meredith, Megan, Ryan, Lucy, Conner, Louise, Peters, Cecilia, Harvey, Dan, Roshdy, Ashraf, Collins, Amy, Sim, Malcolm, Henderson, Steven, Chee, Nigel, Pitts, Sally, Bowman, Katie, Dilawershah, Maria, Vamplew, Luke, Howe, Elizabeth, Rogers, Paula, Hernandez, Clara, Prendergast, Clara, Benton, Jane, Rosenberg, Alex, Forni, Lui G., Grant, Alice, Carvelli, Paula, Raithatha, Ajay, Bird, Sarah, Richardson, Max, Needham, Matthew, Hirst, Claire, Ball, Jonathan, Leaver, Susannah, Howlett, Luisa, Castro Delgado, Carlos, Farnell-Ward, Sarah, Farrah, Helen, Gray, Geraldine, Joseph, Gipsy, Robinson, Francesca, Tridente, Ascanio, Harrop, Clare, Shuker, Karen, McLaughlan, Derek, Ramsey, Judith, Meehan, Sharon, Oliver Rose, Bernd, Reece-Anthony, Rosie, Gurung, Babita, Whitehouse, Tony, Snelson, Catherine, Veenith, Tonny, Johnston, Andy, Cooper, Lauren, Carrera, Ron, Ellis, Karen, Fellows, Emma, Harkett, Samanth, Bergin, Colin, Spruce, Elaine, Despy, Liesl, Goundry, Stephanie, Dooley, Natalie, Mason, Tracy, Clark, Amy, Dignam, Gemma, Ward, Geraldine, Attwood, Ben, Parsons, Penny, Mason, Sophie, Margarson, Michael, Lord, Jenny, McGlone, Philip, Hodgson, Luke E., Chadbourn, Indra, Gomez, Raquel, Margalef, Jordi, Pretorius, Rinus, Hamshere, Alexandra, Carter, Joseph, Cahill, Hazel, Grainger, Lia, Howard, Kate, Forshaw, Greg, Guy, Zoe, Kashani, Kianoush B., Albright, Robert C., Amsbaugh, Amy, Stoltenberg, Anita, Niven, Alexander S., Lynch, Matthew, O’Mara, AnnMarie, Naeem, Syed, Sharif, Sairah, McKenney Goulart, Joyce, Lynch, Matthew, O’Mara, AnnMarie, Naeem, Syed, Sharif, Sairah, McKenney Goulart, Joyce, Tolwani, Ashita, Lyas, Claretha, Latta, Laura, Bihorac, Azra, Hashemighouchani, Haleh, Efron, Philip, Ruppert, Matthew, Cupka, Julie, Kiley, Sean, Carson, Joshua, White, Peggy, Omalay, George, Brown, Sherry, Velez, Laura, Marceron, Alina, Neyra, Javier A., Carlos Aycinena, Juan, Elias, Madona, Ortiz-Soriano, Victor M., Hauschild, Caroline, and Dorfman, Robert

Published
2024
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4. Inhaled Xenon Attenuates Myocardial Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest The Xe-Hypotheca Trial

Author

Arola, Olli, Saraste, Antti, Laitio, Ruut, Airaksinen, Juhani, Hynninen, Marja, Bäcklund, Minna, Ylikoski, Emmi, Wennervirta, Johanna, Pietilä, Mikko, Roine, Risto O, Harjola, Veli-Pekka, Niiranen, Jussi, Korpi, Kirsi, Varpula, Marjut, Scheinin, Harry, Maze, Mervyn, Vahlberg, Tero, Laitio, Timo, Group, Xe-HYPOTHECA Study, Virtanen, Sami, Parkkola, Riitta, Saunavaara, Jani, Martola, Juha, Silvennoinen, Heli, Tiainen, Marjaana, Grönlund, Juha, Inkinen, Outi, Silvasti, Päivi, Nukarinen, Eija, and Olkkola, Klaus T

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Heart Disease, Clinical Research, Cardiovascular, Heart Disease - Coronary Heart Disease, Administration, Inhalation, Aged, Cardiopulmonary Resuscitation, Coma, Female, Finland, Heart, Hemodynamics, Humans, Hypothermia, Induced, Intensive Care Units, Male, Middle Aged, Myocardium, Out-of-Hospital Cardiac Arrest, Percutaneous Coronary Intervention, Treatment Outcome, Troponin T, Xenon, cardioprotection, hypothermia, out-of-hospital cardiac arrest, xenon, Xe-HYPOTHECA Study Group, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BACKGROUND:The authors previously reported that inhaled xenon combined with hypothermia attenuates brain white matter injury in comatose survivors of out-of-hospital cardiac arrest (OHCA). OBJECTIVES:A pre-defined secondary objective was to assess the effect of inhaled xenon on myocardial ischemic damage in the same study population. METHODS:A total of 110 comatose patients who had experienced OHCA from a cardiac cause were randomized to receive either inhaled xenon (40% end-tidal concentration) combined with hypothermia (33°C) for 24 h (n = 55; xenon group) or hypothermia treatment alone (n = 55; control group). Troponin-T levels were measured at hospital admission, and at 24 h, 48 h, and 72 h post-cardiac arrest. All available cases were analyzed for troponin-T release. RESULTS:Troponin-T measurements were available from 54 xenon patients and 54 control patients. The baseline characteristics did not differ significantly between the groups. After adjustments for age, sex, study site, primary coronary percutaneous intervention (PCI), and norepinephrine dose, the mean ± SD post-arrival incremental change of the ln-transformed troponin-T at 72 h was 0.79 ± 1.54 in the xenon group and 1.56 ± 1.38 in the control group (adjusted mean difference -0.66; 95% confidence interval: -1.16 to -0.16; p = 0.01). The effect of xenon on the change in the troponin-T values did not differ in patients with or without PCI or in those with a diagnosis of ST-segment elevation myocardial infarction (group by PCI or ST-segment elevation myocardial infarction interaction effect; p = 0.86 and p = 0.71, respectively). CONCLUSIONS:Among comatose survivors of OHCA, in comparison with hypothermia alone, inhaled xenon combined with hypothermia suggested a less severe myocardial injury as demonstrated by the significantly reduced release of troponin-T.

Published
2017

5. Effect of Inhaled Xenon on Cerebral White Matter Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial

Author

Laitio, Ruut, Hynninen, Marja, Arola, Olli, Virtanen, Sami, Parkkola, Riitta, Saunavaara, Jani, Roine, Risto O, Grönlund, Juha, Ylikoski, Emmi, Wennervirta, Johanna, Bäcklund, Minna, Silvasti, Päivi, Nukarinen, Eija, Tiainen, Marjaana, Saraste, Antti, Pietilä, Mikko, Airaksinen, Juhani, Valanne, Leena, Martola, Juha, Silvennoinen, Heli, Scheinin, Harry, Harjola, Veli-Pekka, Niiranen, Jussi, Korpi, Kirsi, Varpula, Marjut, Inkinen, Outi, Olkkola, Klaus T, Maze, Mervyn, Vahlberg, Tero, and Laitio, Timo

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Clinical Trials and Supportive Activities, Neurosciences, Rehabilitation, Clinical Research, Cardiovascular, Biomedical Imaging, Brain Disorders, Good Health and Well Being, Administration, Inhalation, Adult, Aged, Anisotropy, Cardiopulmonary Resuscitation, Coma, Diffusion Magnetic Resonance Imaging, Female, Finland, Humans, Hypothermia, Induced, Male, Middle Aged, Out-of-Hospital Cardiac Arrest, Single-Blind Method, Statistics, Nonparametric, Survival Analysis, Survivors, Time Factors, Treatment Outcome, White Matter, Xenon, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

ImportanceEvidence from preclinical models indicates that xenon gas can prevent the development of cerebral damage after acute global hypoxic-ischemic brain injury but, thus far, these putative neuroprotective properties have not been reported in human studies.ObjectiveTo determine the effect of inhaled xenon on ischemic white matter damage assessed with magnetic resonance imaging (MRI).Design, setting, and participantsA randomized single-blind phase 2 clinical drug trial conducted between August 2009 and March 2015 at 2 multipurpose intensive care units in Finland. One hundred ten comatose patients (aged 24-76 years) who had experienced out-of-hospital cardiac arrest were randomized.InterventionsPatients were randomly assigned to receive either inhaled xenon combined with hypothermia (33°C) for 24 hours (n = 55 in the xenon group) or hypothermia treatment alone (n = 55 in the control group).Main outcomes and measuresThe primary end point was cerebral white matter damage as evaluated by fractional anisotropy from diffusion tensor MRI scheduled to be performed between 36 and 52 hours after cardiac arrest. Secondary end points included neurological outcome assessed using the modified Rankin Scale (score 0 [no symptoms] through 6 [death]) and mortality at 6 months.ResultsAmong the 110 randomized patients (mean age, 61.5 years; 80 men [72.7%]), all completed the study. There were MRI data from 97 patients (88.2%) a median of 53 hours (interquartile range [IQR], 47-64 hours) after cardiac arrest. The mean global fractional anisotropy values were 0.433 (SD, 0.028) in the xenon group and 0.419 (SD, 0.033) in the control group. The age-, sex-, and site-adjusted mean global fractional anisotropy value was 3.8% higher (95% CI, 1.1%-6.4%) in the xenon group (adjusted mean difference, 0.016 [95% CI, 0.005-0.027], P = .006). At 6 months, 75 patients (68.2%) were alive. Secondary end points at 6 months did not reveal statistically significant differences between the groups. In ordinal analysis of the modified Rankin Scale, the median (IQR) value was 1 (1-6) in the xenon group and 1 (0-6) in the control group (median difference, 0 [95% CI, 0-0]; P = .68). The 6-month mortality rate was 27.3% (15/55) in the xenon group and 34.5% (19/55) in the control group (adjusted hazard ratio, 0.49 [95% CI, 0.23-1.01]; P = .053).Conclusions and relevanceAmong comatose survivors of out-of-hospital cardiac arrest, inhaled xenon combined with hypothermia compared with hypothermia alone resulted in less white matter damage as measured by fractional anisotropy of diffusion tensor MRI. However, there was no statistically significant difference in neurological outcomes or mortality at 6 months. These preliminary findings require further evaluation in an adequately powered clinical trial designed to assess clinical outcomes associated with inhaled xenon among survivors of out-of-hospital cardiac arrest.Trial registrationclinicaltrials.gov Identifier: NCT00879892.

Published
2016

6. Association of oliguria with the development of acute kidney injury in the critically ill

Author

Laru-Sompa, Raili, Pulkkinen, Anni, Saarelainen, Minna, Reilama, Mikko, Tolmunen, Sinikka, Rantalainen, Ulla, Suvela, Markku, Pesola, Katrine, Saastamoinen, Pekka, Pettilä, Ville, Kaukonen, Kirsi-Maija, Korhonen, Anna-Maija, Nisula, Sara, Vaara, Suvi, Suojaranta-Ylinen, Raili, Mildh, Leena, Haapio, Mikko, Nurminen, Laura, Sutinen, Sari, Pettilä, Leena, Laitinen, Helinä, Syrjä, Heidi, Henttonen, Kirsi, Lappi, Elina, Varpula, Tero, Porkka, Päivi, Sivula, Mirka, Rahkonen, Mira, Tsurkka, Anne, Nieminen, Taina, Alaspää, Ari, Salanto, Ville, Juntunen, Hanna, Parviainen, Ilkka, Uusaro, Ari, Ruokonen, Esko, Bendel, Stepani, Rissanen, Niina, Lång, Maarit, Rahikainen, Sari, Rissanen, Saija, Ahonen, Merja, Halonen, Elina, Poukkanen, Meri, Lintula, Esa, Heikkinen, Jorma, Lavander, Timo, Heinonen, Kirsi, Kaminski, Tadeusz, Gäddnäs, Fiia, Kuusela, Tuija, Karlsson, Sari, Reinikainen, Matti, Surakka, Tero, Jyrkönen, Helena, Eiserbeck, Tanja, Ala-Kokko, Tero, Laurila, Jouko, Lund, Vesa, Tuominen, Päivi, Perkola, Pauliina, Tuominen, Riikka, Hietaranta, Marika, Hovilehto, Seppo, Kirsi, Anne, Tiainen, Pekka, Myllärinen, Tuija, Leino, Pirjo, Kuitunen, Anne, Tenhu-nen, Jyrki, Leppänen, Ilona, Levoranta, Markus, Hoppu, Sanna, Sauranen, Jukka, Kukkurainen, Atte, Kortelainen, Samuli, Inkinen, Outi, Koivuviita, Niina, Kotamäki, Jutta, Koivisto, Simo-Pekka, Hautamäki, Raku, Skinnar, Maria, and Vaara, Suvi T.

Published
2016
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8. Predictive value of urine interleukin-18 in the evolution and outcome of acute kidney injury in critically ill adult patients

Author

Laru-Sompa, Raili, Pulkkinen, Anni, Saarelainen, Minna, Reilama, Mikko, Tolmunen, Sinikka, Rantalainen, Ulla, Miettinen, Marja, Suvela, Markku, Pesola, Katrine, Saastamoinen, Pekka, Kauppinen, Sirpa, Pettilä, Ville, Kaukonen, Kirsi-Maija, Korhonen, Anna-Maija, Nisula, Sara, Vaara, Suvi, Suojaranta-Ylinen, Raili, Mildh, Leena, Haapio, Mikko, Nurminen, Laura, Sutinen, Sari, Pettilä, Leena, Laitinen, Helinä, Syrjä, Heidi, Henttonen, Kirsi, Lappi, Elina, Boman, Hillevi, Varpula, Tero, Porkka, Päivi, Mira Rahkonen, Mirka Sivula, Tsurkka, Anne, Nieminen, Taina, Prittinen, Niina, Alaspää, Ari, Salanto, Ville, Juntunen, Hanna, Sanisalo, Teija, Parviainen, Ilkka, Uusaro, Ari, Ruokonen, Esko, Bendel, Stepani, Rissanen, Niina, Lång, Maarit, Rahikainen, Sari, Rissanen, Saija, Ahonen, Merja, Halonen, Elina, Vaskelainen, Eija, Poukkanen, Meri, Lintula, Esa, Suominen, Sirpa, Heikkinen, Jorma, Lavander, Timo, Heinonen, Kirsi, Juopperi, Anne-Mari, Kaminski, Tadeusz, Gäddnäs, Fiia, Kuusela, Tuija, Roiko, Jane, Karlsson, Sari, Reinikainen, Matti, Surakka, Tero, Jyrkönen, Helena, Eiserbeck, Tanja, Kallinen, Jaana, Lund, Vesa, Tuominen, Päivi, Perkola, Pauliina, Tuominen, Riikka, Hietaranta, Marika, Johansson, Satu, Hovilehto, Seppo, Kirsi, Anne, Tiainen, Pekka, Myllärinen, Tuija, Leino, Pirjo, Toropainen, Anne, Kuitunen, Anne, Leppänen, Ilona, Levoranta, Markus, Hoppu, Sanna, Sauranen, Jukka, Tenhunen, Jyrki, Kukkurainen, Atte, Kortelainen, Samuli, Varila, Simo, Inkinen, Outi, Koivuviita, Niina, Kotamäki, Jutta, Laine, Anu, Ala-Kokko, Tero, Laurila, Jouko, Sälkiö, Sinikka, Koivisto, Simo-Pekka, Hautamäki, Raku, Skinnar, Maria, Nisula, S., Yang, R., Poukkanen, M., Vaara, S.T., Kaukonen, K.M., Tallgren, M., Haapio, M., Tenhunen, J., Korhonen, A.M., and Pettilä, V.

Published
2015
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10. Three-year mortality in 30-day survivors of critical care with acute kidney injury: data from the prospective observational FINNAKI study

Author

Mildh, Henriikka, Pettilä, Ville, Korhonen, Anna-Maija, Karlsson, Sari, Ala-Kokko, Tero, Reinikainen, Matti, Vaara, Suvi T., Laru-Sompa, Raili, Pulkkinen, Anni, Saarelainen, Minna, Reilama, Mikko, Tolmunen, Sinikka, Rantalainen, Ulla, Miettinen, Marja, Suvela, Markku, Pesola, Katrine, Saastamoinen, Pekka, Kauppinen, Sirpa, Pettilä, Ville, Kaukonen, Kirsi-Maija, Nisula, Sara, Vaara, Suvi, Suojaranta-Ylinen, Raili, Mildh, Leena, Haapio, Mikko, Nurminen, Laura, Sutinen, Sari, Pettilä, Leena, Laitinen, Helinä, Syrjä, Heidi, Henttonen, Kirsi, Lappi, Elina, Boman, Hillevi, Varpula, Tero, Porkka, Päivi, Sivula, Mirka, Rahkonen, Mira, Tsurkka, Anne, Nieminen, Taina, Pirttinen, Niina, Alaspää, Ari, Salanto, Ville, Juntunen, Hanna, Sanisalo, Teija, Parviainen, Ilkka, Uusaro, Ari, Ruokonen, Esko, Bendel, Stepani, Rissanen, Niina, Lång, Maarit, Rahikainen, Sari, Rissanen, Saija, Ahonen, Merja, Halonen, Elina, Vaskelainen, Eija, Poukkanen, Meri, Lintula, Esa, Suominen, Sirpa, Heikkinen, Jorma, Lavander, Timo, Heinonen, Kirsi, Juopperi, Anne-Mari, Kaminski, Tadeusz, Gäddnäs, Fiia, Kuusela, Tuija, Roiko, Jane, Karlsson, Sari, Reinikainen, Matti, Surakka, Tero, Jyrkönen, Helena, Eiserbeck, Tanja, Kallinen, Jaana, Ala-Kokko, Tero, Laurila, Jouko, Sälkiö, Sinikka, Lund, Vesa, Tuominen, Päivi, Perkola, Pauliina, Tuominen, Riikka, Hietaranta, Marika, Johansson, Satu, Hovilehto, Seppo, Kirsi, Anne, Tiainen, Pekka, Myllärinen, Tuija, Leino, Pirjo, Toropainen, Anne, Kuitunen, Anne, Tenhunen, Jyrki, Leppänen, Ilona, Levoranta, Markus, Hoppu, Sanna, Sauranen, Jukka, Kukkurainen, Atte, Kortelainen, Samuli, Varila, Simo, Inkinen, Outi, Koivuviita, Niina, Kotamäki, Jutta, Laine, Anu, Koivisto, Simo-Pekka, Hautamäki, Raku, Skinnar, Maria, and the FINNAKI Study Group

Published
2016
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11. The Effect of an Accelerated Renal Replacement Therapy Initiation Is Not Modified by Baseline Risk

Author

Angriman, Federico, primary, Ferreyro, Bruno L., additional, Angeloni, Natalia, additional, da Costa, Bruno R., additional, Wald, Ron, additional, Bagshaw, Sean M., additional, Adhikari, Neill K.J., additional, Bellomo, Rinaldo, additional, Dreyfuss, Didier, additional, Du, Bin, additional, Gallagher, Martin P., additional, Gaudry, Stéphane, additional, Lamontagne, François, additional, Joannidis, Michael, additional, Liu, Kathleen D., additional, McAuley, Daniel F., additional, McGuinness, Shay P., additional, Nichol, Alistair D., additional, Ostermann, Marlies, additional, Palevsky, Paul M., additional, Qiu, Haibo, additional, Pettilä, Ville, additional, Schneider, Antoine G., additional, Smith, Orla M., additional, Vaara, Suvi T., additional, Weir, Matthew, additional, Eastwood, Glenn M., additional, Peck, Leah, additional, Young, Helen, additional, Kruger, Peter, additional, Laurie, Gordon, additional, Saylor, Emma, additional, Meyer, Jason, additional, Venz, Ellen, additional, Wetzig, Krista, additional, French, Craig, additional, McGain, Forbes, additional, Mulder, John, additional, Fennessy, Gerard, additional, Koottayi, Sathyajith, additional, Bates, Samantha, additional, Towns, Miriam, additional, Morgan, Rebecca, additional, Tippett, Anna, additional, Udy, Andrew, additional, Mason, Chris, additional, Licari, Elisa, additional, Gantner, Dashiell, additional, McClure, Jason, additional, Nichol, Alistair, additional, McCracken, Phoebe, additional, Board, Jasmin, additional, Martin, Emma, additional, Vallance, Shirley, additional, Young, Meredith, additional, Vladic, Chelsey, additional, McGloughlin, Steve, additional, Gattas, David, additional, Buhr, Heidi, additional, Coles, Jennifer, additional, Hutch, Debra, additional, Wun, James, additional, Cole, Louise, additional, Whitehead, Christina, additional, Lowrey, Julie, additional, Masters, Kristy, additional, Gresham, Rebecca, additional, Campbell, Victoria, additional, Gutierrez, David, additional, Brailsford, Jane, additional, Forbes, Loretta, additional, Murray, Lauren, additional, Maguire, Teena, additional, NiChonghaile, Martina, additional, Orford, Neil, additional, Bone, Allison, additional, Elderkin, Tania, additional, Salerno, Tania, additional, Chimunda, Tim, additional, Fletcher, Jason, additional, Broadfield, Emma, additional, Porwal, Sanjay, additional, Knott, Cameron, additional, Boschert, Catherine, additional, Smith, Julie, additional, Richardson, Angus, additional, Hill, Dianne, additional, Duke, Graeme, additional, Oziemski, Peter, additional, Cegarra, Santiago, additional, Chan, Peter, additional, Welsh, Deborah, additional, Hunter, Stephanie, additional, Roodenburg, Owen, additional, Dyett, John, additional, Kokotsis, Nicos, additional, Moser, Max, additional, Yang, Yang, additional, Padayachee, Laven, additional, Vetro, Joseph, additional, Gangopadhyay, Himangsu, additional, Kaufman, Melissa, additional, Ghosh, Angaj, additional, Said, Simone, additional, Patel, Alpesh, additional, Bihari, Shailesh, additional, Matheson, Elisha, additional, Jin, Xia, additional, Shrestha, Tapaswi, additional, Schwartz, Kate, additional, Cross, Rosalba, additional, Cheung, Winston, additional, Wong, Helen, additional, Kol, Mark, additional, Shah, Asim, additional, Wang, Amanda Y., additional, Endre, Zoltan, additional, Bradford, Celia, additional, Janin, Pierre, additional, Finfer, Simon, additional, Diel, Naomi, additional, Gatward, Jonathan, additional, Hammond, Naomi, additional, Delaney, Anthony, additional, Bass, Frances, additional, Yarad, Elizabeth, additional, Buscher, Hergen, additional, Reynolds, Claire, additional, Baker, Nerilee, additional, Bellmann, Romuald, additional, Peer, Andreas, additional, Hasslacher, Julia, additional, Koglberger, Paul, additional, Klein, Sebastian, additional, Zotter, Klemens, additional, Brandtner, Anna, additional, Finkenstedt, Armin, additional, Ditlbacher, Adelheid, additional, Hartig, Frank, additional, Fries, Dietmar, additional, Bachler, Mirjam, additional, Schenk, Bettina, additional, Wagner, Martin, additional, Eller, Philipp, additional, Staudinger, Thomas, additional, Tiller, Esther, additional, Schellongowski, Peter, additional, Bojic, Andja, additional, Hoste, Eric A., additional, Bracke, Stephanie, additional, Crop, Luc De, additional, Vermeiren, Daisy, additional, Thome, Fernando, additional, Chiella, Bianca, additional, Fendt, Lucia, additional, Antunes, Veronica, additional, D'Aragon, Frédérick, additional, St-Arnaud, Charles, additional, Mayette, Michael, additional, Carbonnaeu, Élaine, additional, Marchand, Joannie, additional, Masse, Marie-Hélène, additional, Ladouceur, Marilène, additional, Turgeon, Alexis F., additional, Lauzier, François, additional, Bellemare, David, additional, Francoeur, Charles Langis, additional, LeBlanc, Guillaume, additional, Guilbault, Gabrielle, additional, Grenier, Stéphanie, additional, Cloutier, Eve, additional, Boivin, Annick, additional, Delisle-Thibault, Charles, additional, Giannakouros, Panagiota, additional, Costerousse, Olivier, additional, Cailhier, Jean-François, additional, Carrier, François-Martin, additional, Ghamraoui, Ali, additional, Lebrasseur, Martine, additional, Benettaib, Fatna, additional, Salamé, Maya, additional, Boumahni, Dounia, additional, Sia, Ying Tung, additional, Naud, Jean-François, additional, Roy, Isabelle, additional, Stelfox, Henry T., additional, Ruddell, Stacey, additional, Manns, Braden J., additional, Duggan, Shelley, additional, Carney, Dominic, additional, Barchard, Jennifer, additional, Whitlock, Richard P., additional, Belley-Cote, Emilie, additional, Savija, Nevena, additional, Sabev, Alexandra, additional, Campbell, Troy, additional, Creary, Thais, additional, Devereaux, Kelson, additional, Brodutch, Shira, additional, Rigatto, Claudio, additional, Paunovic, Bojan, additional, Mooney, Owen, additional, Glybina, Anna, additional, Harasemiw, Oksana, additional, Di Nella, Michelle, additional, Harmon, John, additional, Mehta, Navdeep, additional, Lakatos, Louis, additional, Haslam, Nicole, additional, Lellouche, Francois, additional, Simon, Mathieu, additional, Tung, Ying, additional, Lizotte, Patricia, additional, Bourchard, Pierre-Alexandre, additional, Rochwerg, Bram, additional, Karachi, Tim, additional, Millen, Tina, additional, Muscedere, John, additional, Maslove, David, additional, Boyd, J. Gordon, additional, Sibley, Stephanie, additional, Drover, John, additional, Hunt, Miranda, additional, Georgescu, Ilinca, additional, Wax, Randy, additional, Lenga, Ilan, additional, Sridhar, Kavita, additional, Steele, Andrew, additional, Fusco, Kelly, additional, Ghate, Taneera, additional, Tolibas, Michael, additional, Robinson, Holly, additional, Weir, Matthew A., additional, Taneja, Ravi, additional, Ball, Ian M., additional, Garg, Amit, additional, Campbell, Eileen, additional, Ovsenek, Athena, additional, Diepen, Sean van, additional, Baig, Nadia, additional, Magder, Sheldon, additional, Yao, Han, additional, Alam, Ahsan, additional, Campisi, Josie, additional, MacIntyre, Erika, additional, Rokosh, Ella, additional, Scherr, Kimberly, additional, Lapinsky, Stephen, additional, Mehta, Sangeeta, additional, Shah, Sumesh, additional, Niven, Daniel J., additional, Russell, Michael, additional, Jim, Kym, additional, Brown, Gillian, additional, Oxtoby, Kerry, additional, Hall, Adam, additional, Benoit, Luc, additional, Sokolowski, Colleen, additional, Prasad, Bhanu, additional, Rao, Jag, additional, Giebel, Shelley, additional, Kutsogiannis, Demetrios J., additional, Thompson, Patricia, additional, Thompson, Tayne, additional, Cirone, Robert, additional, Kavikondala, Kanthi, additional, Soth, Mark, additional, Clarke, France, additional, Takaoka, Alyson, additional, Mazer, David, additional, Burns, Karen, additional, Friedrich, Jan, additional, Klein, David, additional, Sandhu, Gyan, additional, Santos, Marlene, additional, Khalid, Imrana, additional, Hodder, Jennifer, additional, Dodek, Peter, additional, Ayas, Najib, additional, Alcuaz, Victoria, additional, Suen, Gabriel, additional, Rewa, Oleksa, additional, Singh, Gurmeet, additional, Norris, Sean, additional, Gibson, Neil, additional, Arias, Castro, additional, Shami, Aysha, additional, Pelletier, Celine, additional, Zahirieh, Alireza, additional, Amaral, Andre, additional, Marinoff, Nicole, additional, Kaur, Navjot, additional, Perez, Adic, additional, Wang, Jane, additional, Haljan, Gregory, additional, Condin, Christopher, additional, McIntyre, Lauralyn, additional, Gomes, Brigette, additional, Porteous, Rebecca, additional, Watpool, Irene, additional, Hiremath, Swapnil, additional, Clark, Edward, additional, Herridge, Margaret S., additional, Backhouse, Felicity, additional, Wilcox, M. Elizabeth, additional, Walczak, Karolina, additional, Ki, Vincent, additional, Sharman, Asheer, additional, Romano, Martin, additional, Gibney, R.T. Noel, additional, Romanovsky, Adam S., additional, McCoshen, Lorena, additional, Wood, Gordon, additional, Ovakim, Daniel, additional, Auld, Fiona, additional, Carney, Gayle, additional, Duan, Meili, additional, Ji, Xiaojun, additional, Guo, Dongchen, additional, Qi, Zhili, additional, Lin, Jin, additional, Zhang, Meng, additional, Dong, Lei, additional, Liu, Jingfeng, additional, Liu, Pei, additional, Zhi, Deyuan, additional, Bai, Guoqiang, additional, Qiu, Yu, additional, Yang, Ziqi, additional, Bai, Jing, additional, Liu, Zhuang, additional, Zhuang, Haizhou, additional, Wang, Haiman, additional, Li, Jian, additional, Zhao, Mengya, additional, Zhou, Xiao, additional, Shi, Xianqing, additional, Ye, Baning, additional, Liu, Manli, additional, Wu, Jing, additional, Fu, Yongjian, additional, Long, Dali, additional, Pan, Yu, additional, Wang, Jinlong, additional, Mei, Huaxian, additional, Zhang, Songsong, additional, Wen, Mingxiang, additional, Yang, Enyu, additional, Mu, Sijie, additional, Li, Jianquan, additional, Hu, Tingting, additional, Qin, Bingyu, additional, Li, Min, additional, Wang, Cunzhen, additional, Dong, Xin, additional, Wang, Kaiwu, additional, Wang, Haibo, additional, Yang, Jianxu, additional, Wang, Chuanyao, additional, Wang, Dongxin, additional, Li, Nan, additional, Yu, Zhui, additional, Xu, Song, additional, Yao, Lan, additional, Hou, Guo, additional, Liu, Zhou, additional, Lu, Liping, additional, Lian, Yingtao, additional, Wang, Chunting, additional, Zhang, Jichen, additional, Ding, Ruiqi, additional, Qi, Guoqing, additional, Wang, Qizhi, additional, Wang, Peng, additional, Meng, Zhaoli, additional, Chen, Man, additional, Hu, Xiaobo, additional, He, Xiandi, additional, Zhao, Shibing, additional, Hang, Lele, additional, Li, Rui, additional, Qin, Suhui, additional, Lu, Kun, additional, Dun, Shijuan, additional, Liu, Cheng, additional, Zhou, Qi, additional, Chen, Zhenzhen, additional, Mei, Jing, additional, Zhang, Minwei, additional, Xu, Hao, additional, Lin, Jincan, additional, Shi, Qindong, additional, Fu, Lijuan, additional, Zeng, Qinjing, additional, Ma, Hongye, additional, Yan, Jinqi, additional, Gao, Lan, additional, Liu, Hongjuan, additional, Zhang, Lei, additional, Li, Hao, additional, He, Xiaona, additional, Fan, Jingqun, additional, Guo, Litao, additional, Liu, Yu, additional, Wang, Xue, additional, Sun, Jingjing, additional, Liu, Zhongmin, additional, Yang, Juan, additional, Ding, Lili, additional, Sheng, Lulu, additional, Liu, Xingang, additional, Yan, Jie, additional, Wang, Quihui, additional, Wang, Yifeng, additional, Zhao, Dan, additional, Zhao, Shuangping, additional, Hu, Chenghuan, additional, Li, Jing, additional, Deng, Fuxing, additional, Qui, Haibo, additional, Yang, Yi, additional, Mo, Min, additional, Pan, Chun, additional, Wu, Changde, additional, Huang, Yingzi, additional, Huang, Lili, additional, Liu, Airan, additional, Korhonen, Anna-Maija, additional, Törnblom, Sanna, additional, Sutinen, Sari, additional, Pettilä, Leena, additional, Heinonen, Jonna, additional, Lappi, Eliria, additional, Suhonen, Taria, additional, Karlsson, Sari, additional, Hoppu, Sanna, additional, Jalkanen, Ville, additional, Kuitunen, Anne, additional, Levoranta, Markus, additional, Långsjö, Jaakko, additional, Ristimäki, Sanna, additional, Malila, Kaisa, additional, Wootten, Anna, additional, Varila, Simo, additional, Järvisalo, Mikko J, additional, Inkinen, Outi, additional, Kentala, Satu, additional, Leivo, Keijo, additional, Haltia, Paivi, additional, Ricard, Jean-Damien, additional, Messika, Jonathan, additional, Tiagarajah, Abirami, additional, Emery, Malo, additional, Dechanet, Aline, additional, Gernez, Coralie, additional, Roux, Damien, additional, Martin-Lefevre, Laurent, additional, Fiancette, Maud, additional, Vinatier, Isabelle, additional, Claude Lacherade, Jean, additional, Colin, Gwenhaël, additional, Lebert, Christine, additional, Azais, Marie-Ange, additional, Yehia, Aihem, additional, Pouplet, Caroline, additional, Henry- Lagarrigue, Matthieu, additional, Seguin, Amélie, additional, Crosby, Laura, additional, Maizel, Julien, additional, Titeca-Beauport, Dimitri, additional, Combes, Alain, additional, Nieszkowska, Ania, additional, Masi, Paul, additional, Demoule, Alexandre, additional, Mayaux, Julien, additional, Dres, Martin, additional, Morawiec, Elise, additional, Decalvele, Maxens, additional, Demiri, Suela, additional, Faure, Morgane, additional, Marios, Clémence, additional, Mallet, Maxime, additional, Ordon, Marie Amélie, additional, Morizot, Laura, additional, Cantien, Marie, additional, Pousset, François, additional, Poirson, Florent, additional, Cohen, Yves, additional, Argaud, Laurent, additional, Cour, Martin, additional, Bitker, Laurent, additional, Simon, Marie, additional, Hernu, Romain, additional, Baudry, Thomas, additional, De La Salle, Sylvie, additional, Robine, Adrien, additional, Sedillot, Nicholas, additional, Tchenio, Xavier, additional, Bouisse, Camille, additional, Roux, Sylvie, additional, Tamion, Fabienne, additional, Grangé, Steven, additional, Carpentier, Dorothée, additional, Chevrel, Guillaume, additional, Ensenyat-Martin, Luis, additional, Marque, Sophie, additional, Quenot, Jean-Pierre, additional, Andreu, Pascal, additional, Dargent, Auguste, additional, Large, Audrey, additional, Chudeau, Nicolas, additional, Landais, Mickael, additional, Derrien, Benoit, additional, Callahan, Jean Christophe, additional, Guitton, Christophe, additional, Le Moal, Charlène, additional, Robert, Alain, additional, Asehnoune, Karim, additional, Cinotti, Raphaël, additional, Grillot, Nicolas, additional, Demeure, Dominique, additional, Vinsonneau, Christophe, additional, Rahmani, Imen, additional, Marzouk, Mehdi, additional, Dekeyser, Thibault, additional, Sejourne, Caroline, additional, Verlay, Mélanie, additional, Thevenin, Fabienne, additional, Delecolle, Lucie, additional, Thevenin, Didier, additional, Souweine, Bertrand, additional, Coupez, Elisabeth, additional, Adda, Mireille, additional, Eraldi, Jean-Pierre, additional, Marchalot, Antoine, additional, Prost, Nicolas De, additional, Dessap, Armand Mekontso, additional, Razazi, Keyvan, additional, Meziani, Ferhat, additional, Boisrame-Helms, Julie, additional, Clere-Jehl, Raphael, additional, Delabranche, Xavier, additional, Kummerlen, Christine, additional, Merdji, Hamid, additional, Monnier, Alexandra, additional, Rabouel, Yannick, additional, Rahmani, Hassene, additional, Allam, Hayat, additional, Chenaf, Samir, additional, Franja, Vincenta, additional, Pons, Bertrand, additional, Carles, Michel, additional, Martino, Frédéric, additional, Richard, Régine, additional, Zuber, Benjamin, additional, Lacave, Guillaume, additional, Lakhal, Karim, additional, Rozec, Bertrand, additional, Van, Hoa Dang, additional, Boulet, Éric, additional, Fadel, Fouad, additional, Cleophax, Cedric, additional, Dufour, Nicolas, additional, Grant, Caroline, additional, Thuong, Marie, additional, Reignier, Jean, additional, Canet, Emmanuel, additional, Nicolet, Laurent, additional, Boulain, Thierry, additional, Nay, Mai-Anh, additional, Benzekri, Dalila, additional, Barbier, François, additional, Bretagnol, Anne, additional, Kamel, Toufik, additional, Mathonnet, Armelle, additional, Muller, Grégoire, additional, Skarzynski, Marie, additional, Rossi, Julie, additional, Pradet, Amandine, additional, Santos, Sandra Dos, additional, Guery, Aurore, additional, Muller, Lucie, additional, Felix, Luis, additional, Bohé, Julien, additional, Thiéry, Guillaume, additional, Aissaoui, Nadia, additional, Vimpere, Damien, additional, Commeureuc, Morgane, additional, Diehl, Jean-Luc, additional, Guerot, Emmanuel, additional, Liangos, Orfeas, additional, Wittig, Monika, additional, Zarbock, Alexander, additional, Küllmar, Mira, additional, van Waegeningh, Thomas, additional, Rosenow, Nadine, additional, Brickell, Kathy, additional, Doran, Peter, additional, Murray, Patrick T., additional, Landoni, Giovanni, additional, Lembo, Rosalba, additional, Zangrillo, Alberto, additional, Monti, Giacomo, additional, Tozzi, Margherita, additional, Marzaroli, Matteo, additional, Lombardi, Gaetano, additional, Paternoster, Gianluca, additional, Vitiello, Michelangelo, additional, McGuinness, Shay, additional, Parke, Rachael, additional, Butler, Magdalena, additional, Gilder, Eileen, additional, Cowdrey, Keri-Anne, additional, Wallace, Samantha, additional, Hallion, Jane, additional, Woolett, Melissa, additional, Neal, Philippa, additional, Duffy, Karina, additional, Long, Stephanie, additional, McArthur, Colin, additional, Simmonds, Catherine, additional, Chen, Yan, additional, McConnochie, Rachael, additional, Newby, Lynette, additional, Knight, David, additional, Henderson, Seton, additional, Mehrtens, Jan, additional, Morgan, Stacey, additional, Morris, Anna, additional, Hayden, Kymbalee Vander, additional, Burke, Tara, additional, Bailey, Matthew, additional, Freebairn, Ross, additional, Chadwick, Lesley, additional, Park, Penelope, additional, Rolls, Christine, additional, Thomas, Liz, additional, Buehner, Ulrike, additional, Williams, Erin, additional, Albrett, Jonathan, additional, Kirkham, Simon, additional, Jackson, Carolyn, additional, Browne, Troy, additional, Goodson, Jennifer, additional, Jackson, David, additional, Houghton, James, additional, Callender, Owen, additional, Higson, Vicki, additional, Keet, Owen, additional, Dominy, Clive, additional, Young, Paul, additional, Hunt, Anna, additional, Judd, Harriet, additional, Lawrence, Cassie, additional, Olatunji, Shaanti, additional, Robertson, Yvonne, additional, Latimer-Bell, Charlotte, additional, Hendry, Deborah, additional, Mckay-Vucago, Agnes, additional, Beehre, Nina, additional, Lesona, Eden, additional, Navarra, Leanlove, additional, Robinson, Chelsea, additional, Jang, Ryan, additional, Junge, Andrea, additional, Lambert, Bridget, additional, Thibault, Michel, additional, Eckert, Philippe, additional, Kissling, Sébastien, additional, Polychronopoulos, Erietta, additional, Poli, Elettra, additional, Altarelli, Marco, additional, Schnorf, Madeleine, additional, Mallaird, Samia Abed, additional, Heidegger, Claudia, additional, Perret, Aurelie, additional, Montillier, Philippe, additional, Sangla, Frederic, additional, Neils, Seigenthaller, additional, Watteville, Aude De, additional, Phull, Mandeep-Kaur, additional, George, Aparna, additional, Hussain, Nauman, additional, Pogreban, Tatiana, additional, Lobaz, Steve, additional, Daniels, Alison, additional, Cunningham, Mishell, additional, Kerr, Deborah, additional, Nicholson, Alice, additional, Shanmugasundaram, Pradeep, additional, Abrams, Judith, additional, Manso, Katarina, additional, Hambrook, Geraldine, additional, McKerrow, Elizabeth, additional, Salva, Juvy, additional, Foulkes, Stephen, additional, Wise, Matthew, additional, Morgan, Matt, additional, Brooks, Jenny, additional, Cole, Jade, additional, Davies, Tracy Michelle, additional, Hill, Helen, additional, Thomas, Emma, additional, Vizcaychipi, Marcela, additional, Baharlo, Behrad, additional, Carungcong, Jaime, additional, Costa, Patricia, additional, Martins, Laura, additional, Kapoor, Ritoo, additional, Hazelton, Tracy, additional, Moon, Angela, additional, Musselwhite, Janine, additional, Shelley, Ben, additional, McCall, Philip, additional, Arbane, Gill, additional, Bociek, Aneta, additional, Marotti, Martina, additional, Lim, Rosario, additional, Campos, Sara, additional, Novellas, Neus Grau, additional, Cennamo, Armando, additional, Slack, Andrew, additional, Wyncoll, Duncan, additional, Camporota, Luigi, additional, Sparkes, Simon, additional, Tilley, Rosalinde, additional, Rattray, Austin, additional, Moreland, Gayle, additional, Duffy, Jane, additional, McGonigal, Elizabeth, additional, Hopkins, Philip, additional, Finney, Clare, additional, Smith, John, additional, Noble, Harriet, additional, Watson, Hayley, additional, Harris, Claire-Louise, additional, Clarey, Emma, additional, Corcoran, Eleanor, additional, Beck, James, additional, Howcroft, Clare, additional, Youngs, Nora, additional, Wilby, Elizabeth, additional, Ogg, Bethan, additional, Wolverson, Adam, additional, Lee, Sandra, additional, Butler, Susie, additional, Okubanjo, Maryanne, additional, Hindle, Julia, additional, Welters, Ingeborg, additional, Williams, Karen, additional, Johnson, Emily, additional, Patrick-Heselton, Julie, additional, Shaw, David, additional, Waugh, Victoria, additional, Stewart, Richard, additional, Mwaura, Esther, additional, Wren, Lynn, additional, Mew, Louise, additional, Sutherland, Sara-Beth, additional, Adderley, Jane, additional, Ruddy, Jim, additional, Harkins, Margaret, additional, Kaye, Callum, additional, Scott, Teresa, additional, Mitchell, Wendy, additional, Anderson, Felicity, additional, Willox, Fiona, additional, Jagannathan, Vijay, additional, Clark, Michele, additional, Purv, Sarah, additional, Sharman, Andrew, additional, Meredith, Megan, additional, Ryan, Lucy, additional, Conner, Louise, additional, Peters, Cecilia, additional, Harvey, Dan, additional, Roshdy, Ashraf, additional, Collins, Amy, additional, Sim, Malcolm, additional, Henderson, Steven, additional, Chee, Nigel, additional, Pitts, Sally, additional, Bowman, Katie, additional, Dilawershah, Maria, additional, Vamplew, Luke, additional, Howe, Elizabeth, additional, Rogers, Paula, additional, Hernandez, Clara, additional, Prendergast, Clara, additional, Benton, Jane, additional, Rosenberg, Alex, additional, Forni, Lui G., additional, Grant, Alice, additional, Carvelli, Paula, additional, Raithatha, Ajay, additional, Bird, Sarah, additional, Richardson, Max, additional, Needham, Matthew, additional, Hirst, Claire, additional, Ball, Jonathan, additional, Leaver, Susannah, additional, Howlett, Luisa, additional, Delgado, Carlos Castro, additional, Farnell-Ward, Sarah, additional, Farrah, Helen, additional, Gray, Geraldine, additional, Joseph, Gipsy, additional, Robinson, Francesca, additional, Tridente, Ascanio, additional, Harrop, Clare, additional, Shuker, Karen, additional, McLaughlan, Derek, additional, Ramsey, Judith, additional, Meehan, Sharon, additional, Rose, Bernd Oliver, additional, Reece-Anthony, Rosie, additional, Gurung, Babita, additional, Whitehouse, Tony, additional, Snelson, Catherine, additional, Veenith, Tonny, additional, Johnston, Andy, additional, Cooper, Lauren, additional, Carrera, Ron, additional, Ellis, Karen, additional, Fellows, Emma, additional, Harkett, Samanth, additional, Bergin, Colin, additional, Spruce, Elaine, additional, Despy, Liesl, additional, Goundry, Stephanie, additional, Dooley, Natalie, additional, Mason, Tracy, additional, Clark, Amy, additional, Dignam, Gemma, additional, Ward, Geraldine, additional, Attwood, Ben, additional, Parsons, Penny, additional, Mason, Sophie, additional, Margarson, Michael, additional, Lord, Jenny, additional, McGlone, Philip, additional, Hodgson, Luke E., additional, Chadbourn, Indra, additional, Gomez, Raquel, additional, Margalef, Jordi, additional, Pretorius, Rinus, additional, Hamshere, Alexandra, additional, Carter, Joseph, additional, Cahill, Hazel, additional, Grainger, Lia, additional, Howard, Kate, additional, Forshaw, Greg, additional, Guy, Zoe, additional, Kashani, Kianoush B., additional, Albright, Robert C., additional, Amsbaugh, Amy, additional, Stoltenberg, Anita, additional, Niven, Alexander S., additional, Lynch, Matthew, additional, O'Mara, AnnMarie, additional, Naeem, Syed, additional, Sharif, Sairah, additional, Goulart, Joyce McKenney, additional, Tolwani, Ashita, additional, Lyas, Claretha, additional, Latta, Laura, additional, Bihorac, Azra, additional, Hashemighouchani, Haleh, additional, Efron, Philip, additional, Ruppert, Matthew, additional, Cupka, Julie, additional, Kiley, Sean, additional, Carson, Joshua, additional, White, Peggy, additional, Omalay, George, additional, Brown, Sherry, additional, Velez, Laura, additional, Marceron, Alina, additional, Neyra, Javier A., additional, Aycinena, Juan Carlos, additional, Elias, Madona, additional, Ortiz-Soriano, Victor M., additional, Hauschild, Caroline, additional, and Dorfman, Robert, additional

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2022
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13. A Bayesian reanalysis of the standard versus accelerated initiation of renal-replacement therapy in acute kidney injury (STARRT-AKI) trial

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Zampieri, Fernando G., da Costa, Bruno R., Vaara, Suvi T., Lamontagne, François, Rochwerg, Bram, Nichol, Alistair D., McGuinness, Shay, McAuley, Danny F., Ostermann, Marlies, Wald, Ron, Bagshaw, Sean M., Adhikari, Neill K. J., Bellomo, Rinaldo, Dreyfuss, Didier, Du, Bin, Gallagher, Martin P., Gaudry, Stéphane, Joannidis, Michael, Liu, Kathleen D., McAuley, Daniel F., McGuinness, Shay P., Palevsky, Paul M., Qiu, Haibo, Pettilä, Ville, Schneider, Antoine G., Smith, Orla M., Vaara, Suvi, Weir, Matthew, Eastwood, Glenn M., Peck, Leah, Young, Helen, Kruger, Peter, Laurie, Gordon, Saylor, Emma, Meyer, Jason, Venz, Ellen, Wetzig, Krista, French, Craig, McGain, Forbes, Mulder, John, Fennessy, Gerard, Koottayi, Sathyajith, Bates, Samantha, Towns, Miriam, Morgan, Rebecca, Tippett, Anna, Udy, Andrew, Mason, Chris, Licari, Elisa, Gantner, Dashiell, McClure, Jason, Nichol, Alistair, McCracken, Phoebe, Board, Jasmin, Martin, Emma, Vallance, Shirley, Young, Meredith, Vladic, Chelsey, McGloughlin, Steve, Gattas, David, Buhr, Heidi, Coles, Jennifer, Hutch, Debra, Wun, James, Cole, Louise, Whitehead, Christina, Lowrey, Julie, Masters, Kristy, Gresham, Rebecca, Campbell, Victoria, Gutierrez, David, Brailsford, Jane, Forbes, Loretta, Murray, Lauren, Maguire, Teena, NiChonghaile, Martina, Orford, Neil, Bone, Allison, Elderkin, Tania, Salerno, Tania, Chimunda, Tim, Fletcher, Jason, Broadfield, Emma, Porwal, Sanjay, Knott, Cameron, Boschert, Catherine, Smith, Julie, Richardson, Angus, Hill, Dianne, Duke, Graeme, Oziemski, Peter, Cegarra, Santiago, Chan, Peter, Welsh, Deborah, Hunter, Stephanie, Roodenburg, Owen, Dyett, John, Kokotsis, Nicos, Moser, Max, Yang, Yang, Padayachee, Laven, Vetro, Joseph, Gangopadhyay, Himangsu, Kaufman, Melissa, Ghosh, Angaj, Said, Simone, Patel, Alpesh, Bihari, Shailesh, Matheson, Elisha, Jin, Xia, Shrestha, Tapaswi, Schwartz, Kate, Cross, Rosalba, Cheung, Winston, Wong, Helen, Kol, Mark, Shah, Asim, Wang, Amanda Y., Endre, Zoltan, Bradford, Celia, Janin, Pierre, Finfer, Simon, Diel, Naomi, Gatward, Jonathan, Hammond, Naomi, Delaney, Anthony, Bass, Frances, Yarad, Elizabeth, Buscher, Hergen, Reynolds, Claire, Baker, Nerilee, Bellmann, Romuald, Peer, Andreas, Hasslacher, Julia, Koglberger, Paul, Klein, Sebastian, Zotter, Klemens, Brandtner, Anna, Finkenstedt, Armin, Ditlbacher, Adelheid, Hartig, Frank, Fries, Dietmar, Bachler, Mirjam, Schenk, Bettina, Wagner, Martin, Eller, Philipp, Staudinger, Thomas, Tiller, Esther, Schellongowski, Peter, Bojic, Andja, Hoste, Eric, Bracke, Stephanie, De Crop, Luc, Vermeiren, Daisy, Thome, Fernando, Chiella, Bianca, Fendt, Lucia, Antunes, Veronica, Lafrance, Jean-Philippe, D’Aragon, Frédérick, St-Arnaud, Charles, Mayette, Michael, Carbonnaeu, Élaine, Marchand, Joannie, Masse, Marie-Hélène, Ladouceur, Marilène, Turgeon, Alexis F., Lauzier, François, Bellemare, David, Francoeur, Charles Langis, LeBlanc, Guillaume, Guilbault, Gabrielle, Grenier, Stéphanie, Cloutier, Eve, Boivin, Annick, Delisle-Thibault, Charles, Giannakouros, Panagiota, Costerousse, Olivier, Cailhier, Jean-François, Carrier, François-Martin, Ghamraoui, Ali, Lebrasseur, Martine, Benettaib, Fatna, Salamé, Maya, Boumahni, Dounia, Sia, Ying Tung, Naud, Jean-François, Roy, Isabelle, Stelfox, Henry T., Ruddell, Stacey, Manns, Braden J., Duggan, Shelley, Carney, Dominic, Barchard, Jennifer, Whitlock, Richard P., Belley-Cote, Emilie, Savija, Nevena, Sabev, Alexandra, Campbell, Troy, Creary, Thais, Devereaux, Kelson, Brodutch, Shira, Rigatto, Claudio, Paunovic, Bojan, Mooney, Owen, Glybina, Anna, Harasemiw, Oksana, Di Nella, Michelle, Harmon, John, Mehta, Navdeep, Lakatos, Louis, Haslam, Nicole, Lellouche, Francois, Simon, Mathieu, Tung, Ying, Lizotte, Patricia, Bourchard, Pierre-Alexandre, Karachi, Tim, Millen, Tina, Muscedere, John, Maslove, David, Gordon Boyd, J., Sibley, Stephanie, Drover, John, Hunt, Miranda, Georgescu, Ilinca, Wax, Randy, Lenga, Ilan, Sridhar, Kavita, Steele, Andrew, Fusco, Kelly, Ghate, Taneera, Tolibas, Michael, Robinson, Holly, Weir, Matthew A., Taneja, Ravi, Ball, Ian M., Garg, Amit, Campbell, Eileen, Ovsenek, Athena, van Diepen, Sean, Baig, Nadia, Magder, Sheldon, Yao, Han, Alam, Ahsan, Campisi, Josie, MacIntyre, Erika, Rokosh, Ella, Scherr, Kimberly, Lapinsky, Stephen, Mehta, Sangeeta, Shah, Sumesh, Niven, Daniel J., Russell, Michael, Jim, Kym, Brown, Gillian, Oxtoby, Kerry, Hall, Adam, Benoit, Luc, Sokolowski, Colleen, Prasad, Bhanu, Rao, Jag, Giebel, Shelley, Kutsogiannis, Demetrios J., Thompson, Patricia, Thompson, Tayne, Cirone, Robert, Kavikondala, Kanthi, Soth, Mark, Clarke, France, Takaoka, Alyson, Mazer, David, Burns, Karen, Friedrich, Jan, Klein, David, Sandhu, Gyan, Santos, Marlene, Khalid, Imrana, Hodder, Jennifer, Dodek, Peter, Ayas, Najib, Alcuaz, Victoria, Suen, Gabriel, Rewa, Oleksa, Singh, Gurmeet, Norris, Sean, Gibson, Neil, Arias, Castro, Shami, Aysha, Pelletier, Celine, Zahirieh, Alireza, Amaral, Andre, Marinoff, Nicole, Kaur, Navjot, Perez, Adic, Wang, Jane, Haljan, Gregory, Condin, Christopher, McIntyre, Lauralyn, Gomes, Brigette, Porteous, Rebecca, Watpool, Irene, Hiremath, Swapnil, Clark, Edward, Herridge, Margaret S., Backhouse, Felicity, Elizabeth Wilcox, M., Walczak, Karolina, Ki, Vincent, Sharman, Asheer, Romano, Martin, Noel Gibney, R. T., Romanovsky, Adam S., McCoshen, Lorena, Wood, Gordon, Ovakim, Daniel, Auld, Fiona, Carney, Gayle, Duan, Meili, Ji, Xiaojun, Guo, Dongchen, Qi, Zhili, Lin, Jin, Zhang, Meng, Dong, Lei, Liu, Jingfeng, Liu, Pei, Zhi, Deyuan, Bai, Guoqiang, Qiu, Yu, Yang, Ziqi, Bai, Jing, Liu, Zhuang, Zhuang, Haizhou, Wang, Haiman, Li, Jian, Zhao, Mengya, Zhou, Xiao, Shi, Xianqing, Ye, Baning, Liu, Manli, Wu, Jing, Fu, Yongjian, Long, Dali, Pan, Yu, Wang, Jinlong, Mei, Huaxian, Zhang, Songsong, Wen, Mingxiang, Yang, Enyu, Mu, Sijie, Li, Jianquan, Hu, Tingting, Qin, Bingyu, Li, Min, Wang, Cunzhen, Dong, Xin, Wang, Kaiwu, Wang, Haibo, Yang, Jianxu, Wang, Chuanyao, Wang, Dongxin, Li, Nan, Yu, Zhui, Xu, Song, Yao, Lan, Hou, Guo, Liu, Zhou, Lu, Liping, Lian, Yingtao, Wang, Chunting, Zhang, Jichen, Ding, Ruiqi, Qi, Guoqing, Wang, Qizhi, Wang, Peng, Meng, Zhaoli, Chen, Man, Hu, Xiaobo, He, Xiandi, Zhao, Shibing, Hang, Lele, Li, Rui, Qin, Suhui, Lu, Kun, Dun, Shijuan, Liu, Cheng, Zhou, Qi, Chen, Zhenzhen, Mei, Jing, Zhang, Minwei, Xu, Hao, Lin, Jincan, Shi, Qindong, Fu, Lijuan, Zeng, Qinjing, Ma, Hongye, Yan, Jinqi, Gao, Lan, Liu, Hongjuan, Zhang, Lei, Li, Hao, He, Xiaona, Fan, Jingqun, Guo, Litao, Liu, Yu, Wang, Xue, Sun, Jingjing, Liu, Zhongmin, Yang, Juan, Ding, Lili, Sheng, Lulu, Liu, Xingang, Yan, Jie, Wang, Quihui, Wang, Yifeng, Zhao, Dan, Zhao, Shuangping, Hu, Chenghuan, Li, Jing, Deng, Fuxing, Qui, Haibo, Yang, Yi, Mo, Min, Pan, Chun, Wu, Changde, Huang, Yingzi, Huang, Lili, Liu, Airan, Korhonen, Anna-Maija, Törnblom, Sanna, Sutinen, Sari, Pettilä, Leena, Heinonen, Jonna, Lappi, Eliria, Suhonen, Taria, Karlsson, Sari, Hoppu, Sanna, Jalkanen, Ville, Kuitunen, Anne, Levoranta, Markus, Långsjö, Jaakko, Ristimäki, Sanna, Malila, Kaisa, Wootten, Anna, Varila, Simo, Järvisalo, Mikko J., Inkinen, Outi, Kentala, Satu, Leivo, Keijo, Haltia, Paivi, Ricard, Jean-Damien, Messika, Jonathan, Tiagarajah, Abirami, Emery, Malo, Dechanet, Aline, Gernez, Coralie, Roux, Damien, Martin-Lefevre, Laurent, Fiancette, Maud, Vinatier, Isabelle, Lacherade, Jean Claude, Colin, Gwenhaël, Lebert, Christine, Azais, Marie-Ange, Yehia, Aihem, Pouplet, Caroline, Lagarrigue, Matthieu Henry, Seguin, Amélie, Crosby, Laura, Maizel, Julien, Titeca-Beauport, Dimitri, Combes, Alain, Nieszkowska, Ania, Masi, Paul, Demoule, Alexandre, Mayaux, Julien, Dres, Martin, Morawiec, Elise, Decalvele, Maxens, Demiri, Suela, Faure, Morgane, Marios, Clémence, Mallet, Maxime, Ordon, Marie Amélie, Morizot, Laura, Cantien, Marie, Pousset, François, Poirson, Florent, Cohen, Yves, Argaud, Laurent, Cour, Martin, Bitker, Laurent, Simon, Marie, Hernu, Romain, Baudry, Thomas, De La Salle, Sylvie, Robine, Adrien, Sedillot, Nicholas, Tchenio, Xavier, Bouisse, Camille, Roux, Sylvie, Barbar, Saber Davide, Trusson, Rémi, Tamion, Fabienne, Grangé, Steven, Carpentier, Dorothée, Chevrel, Guillaume, Ensenyat-Martin, Luis, Marque, Sophie, Quenot, Jean-Pierre, Andreu, Pascal, Dargent, Auguste, Large, Audrey, Chudeau, Nicolas, Landais, Mickael, Derrien, Benoit, Callahan, Jean Christophe, Guitton, Christophe, Le Moal, Charlène, Robert, Alain, Asehnoune, Karim, Cinotti, Raphaël, Grillot, Nicolas, Demeure, Dominique, Vinsonneau, Christophe, Rahmani, Imen, Marzouk, Mehdi, Dekeyser, Thibault, Sejourne, Caroline, Verlay, Mélanie, Thevenin, Fabienne, Delecolle, Lucie, Thevenin, Didier, Souweine, Bertrand, Coupez, Elisabeth, Adda, Mireille, Eraldi, Jean-Pierre, Marchalot, Antoine, De Prost, Nicolas, Dessap, Armand Mekontso, Razazi, Keyvan, Meziani, Ferhat, Boisrame-Helms, Julie, Clere-Jehl, Raphael, Delabranche, Xavier, Kummerlen, Christine, Merdji, Hamid, Monnier, Alexandra, Rabouel, Yannick, Rahmani, Hassene, Allam, Hayat, Chenaf, Samir, Franja, Vincenta, Pons, Bertrand, Carles, Michel, Martino, Frédéric, Richard, Régine, Zuber, Benjamin, Lacave, Guillaume, Lakhal, Karim, Rozec, Bertrand, Van, Hoa Dang, Boulet, Éric, Fadel, Fouad, Cleophax, Cedric, Dufour, Nicolas, Grant, Caroline, Thuong, Marie, Reignier, Jean, Canet, Emmanuel, Nicolet, Laurent, Boulain, Thierry, Nay, Mai-Anh, Benzekri, Dalila, Barbier, François, Bretagnol, Anne, Kamel, Toufik, Mathonnet, Armelle, Muller, Grégoire, Skarzynski, Marie, Rossi, Julie, Pradet, Amandine, Dos Santos, Sandra, Guery, Aurore, Muller, Lucie, Felix, Luis, Bohé, Julien, Thiéry, Guillaume, Aissaoui, Nadia, Vimpere, Damien, Commeureuc, Morgane, Diehl, Jean-Luc, Guerot, Emmanuel, Liangos, Orfeas, Wittig, Monika, Zarbock, Alexander, Küllmar, Mira, van Waegeningh, Thomas, Rosenow, Nadine, Brickell, Kathy, Doran, Peter, Murray, Patrick T., Landoni, Giovanni, Lembo, Rosalba, Zangrillo, Alberto, Monti, Giacomo, Tozzi, Margherita, Marzaroli, Matteo, Lombardi, Gaetano, Paternoster, Gianluca, Vitiello, Michelangelo, Parke, Rachael, Butler, Magdalena, Gilder, Eileen, Cowdrey, Keri-Anne, Wallace, Samantha, Hallion, Jane, Woolett, Melissa, Neal, Philippa, Duffy, Karina, Long, Stephanie, McArthur, Colin, Simmonds, Catherine, Chen, Yan, McConnochie, Rachael, Newby, Lynette, Knight, David, Henderson, Seton, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Vander Hayden, Kymbalee, Burke, Tara, Bailey, Matthew, Freebairn, Ross, Chadwick, Lesley, Park, Penelope, Rolls, Christine, Thomas, Liz, Buehner, Ulrike, Williams, Erin, Albrett, Jonathan, Kirkham, Simon, Jackson, Carolyn, Browne, Troy, Goodson, Jennifer, Jackson, David, Houghton, James, Callender, Owen, Higson, Vicki, Keet, Owen, Dominy, Clive, Young, Paul, Hunt, Anna, Judd, Harriet, Lawrence, Cassie, Olatunji, Shaanti, Robertson, Yvonne, Latimer-Bell, Charlotte, Hendry, Deborah, Mckay-Vucago, Agnes, Beehre, Nina, Lesona, Eden, Navarra, Leanlove, Robinson, Chelsea, Jang, Ryan, Junge, Andrea, Lambert, Bridget, Thibault, Michel, Eckert, Philippe, Kissling, Sébastien, Polychronopoulos, Erietta, Poli, Elettra, Altarelli, Marco, Schnorf, Madeleine, Mallaird, Samia Abed, Heidegger, Claudia, Perret, Aurelie, Montillier, Philippe, Sangla, Frederic, Neils, Seigenthaller, De Watteville, Aude, Phull, Mandeep-Kaur, George, Aparna, Hussain, Nauman, Pogreban, Tatiana, Lobaz, Steve, Daniels, Alison, Cunningham, Mishell, Kerr, Deborah, Nicholson, Alice, Shanmugasundaram, Pradeep, Abrams, Judith, Manso, Katarina, Hambrook, Geraldine, McKerrow, Elizabeth, Salva, Juvy, Foulkes, Stephen, Wise, Matthew, Morgan, Matt, Brooks, Jenny, Cole, Jade, Davies, Tracy Michelle, Hill, Helen, Thomas, Emma, Vizcaychipi, Marcela, Baharlo, Behrad, Carungcong, Jaime, Costa, Patricia, Martins, Laura, Kapoor, Ritoo, Hazelton, Tracy, Moon, Angela, Musselwhite, Janine, Shelley, Ben, McCall, Philip, Arbane, Gill, Bociek, Aneta, Marotti, Martina, Lim, Rosario, Campos, Sara, Novellas, Neus Grau, Cennamo, Armando, Slack, Andrew, Wyncoll, Duncan, Camporota, Luigi, Sparkes, Simon, Tilley, Rosalinde, Rattray, Austin, Moreland, Gayle, Duffy, Jane, McGonigal, Elizabeth, Hopkins, Philip, Finney, Clare, Smith, John, Noble, Harriet, Watson, Hayley, Harris, Claire-Louise, Clarey, Emma, Corcoran, Eleanor, Beck, James, Howcroft, Clare, Youngs, Nora, Wilby, Elizabeth, Ogg, Bethan, Wolverson, Adam, Lee, Sandra, Butler, Susie, Okubanjo, Maryanne, Hindle, Julia, Welters, Ingeborg, Williams, Karen, Johnson, Emily, Patrick-Heselton, Julie, Shaw, David, Waugh, Victoria, Stewart, Richard, Mwaura, Esther, Wren, Lynn, Mew, Louise, Sutherland, Sara-Beth, Adderley, Jane, Ruddy, Jim, Harkins, Margaret, Kaye, Callum, Scott, Teresa, Mitchell, Wendy, Anderson, Felicity, Willox, Fiona, Jagannathan, Vijay, Clark, Michele, Purv, Sarah, Sharman, Andrew, Meredith, Megan, Ryan, Lucy, Conner, Louise, Peters, Cecilia, Harvey, Dan, Roshdy, Ashraf, Collins, Amy, Sim, Malcolm, Henderson, Steven, Chee, Nigel, Pitts, Sally, Bowman, Katie, Dilawershah, Maria, Vamplew, Luke, Howe, Elizabeth, Rogers, Paula, Hernandez, Clara, Prendergast, Clara, Benton, Jane, Rosenberg, Alex, Forni, Lui G., Grant, Alice, Carvelli, Paula, Raithatha, Ajay, Bird, Sarah, Richardson, Max, Needham, Matthew, Hirst, Claire, Ball, Jonathan, Leaver, Susannah, Howlett, Luisa, Delgado, Carlos Castro, Farnell-Ward, Sarah, Farrah, Helen, Gray, Geraldine, Joseph, Gipsy, Robinson, Francesca, Tridente, Ascanio, Harrop, Clare, Shuker, Karen, McLaughlan, Derek, Ramsey, Judith, Meehan, Sharon, Rose, Bernd Oliver, Reece-Anthony, Rosie, Gurung, Babita, Whitehouse, Tony, Snelson, Catherine, Veenith, Tonny, Johnston, Andy, Cooper, Lauren, Carrera, Ron, Ellis, Karen, Fellows, Emma, Harkett, Samanth, Bergin, Colin, Spruce, Elaine, Despy, Liesl, Goundry, Stephanie, Dooley, Natalie, Mason, Tracy, Clark, Amy, Dignam, Gemma, Ward, Geraldine, Attwood, Ben, Parsons, Penny, Mason, Sophie, Margarson, Michael, Lord, Jenny, McGlone, Philip, Hodgson, Luke E., Chadbourn, Indra, Gomez, Raquel, Margalef, Jordi, Pretorius, Rinus, Hamshere, Alexandra, Carter, Joseph, Cahill, Hazel, Grainger, Lia, Howard, Kate, Forshaw, Greg, Guy, Zoe, Kashani, Kianoush B., Albright, Robert C., Amsbaugh, Amy, Stoltenberg, Anita, Niven, Alexander S., Lynch, Matthew, O’Mara, AnnMarie, Naeem, Syed, Sharif, Sairah, Goulart, Joyce McKenney, Tolwani, Ashita, Lyas, Claretha, Latta, Laura, Bihorac, Azra, Hashemighouchani, Haleh, Efron, Philip, Ruppert, Matthew, Cupka, Julie, Kiley, Sean, Carson, Joshua, White, Peggy, Omalay, George, Brown, Sherry, Velez, Laura, Marceron, Alina, Neyra, Javier A., Aycinena, Juan Carlos, Elias, Madona, Ortiz-Soriano, Victor M., Hauschild, Caroline, Dorfman, Robert, Investigators, STARRT-AKI, Investigators, STARRT-AKI, Zampieri Fernando, G, da Costa Bruno, R, Vaara Suvi, T, Lamontagne, Françoi, Rochwerg, Bram, Nichol Alistair, D, Mcguinness, Shay, McAuley Danny, F, Ostermann, Marlie, Wald, Ron, Bagshaw Sean, M, STARRT-AKI, Investigator, Landoni, G, and Zangrillo, A

Subjects
Kidney-replacement therapy, Critical Illness, Acute Kidney Injury/therapy, Randomized, Bayes Theorem, Acute Kidney Injury, Critical Care and Intensive Care Medicine, Bayesian, Trial, Acute kidney injury, Renal Replacement Therapy, Renal Replacement Therapy/methods, Critical Illness/therapy, Medicine and Health Sciences, Humans, Mortality, Dialysis, Probability
Abstract

Background Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial compared two strategies of KRT initiation (accelerated versus standard) in critically ill patients with acute kidney injury and found neutral results for 90-day all-cause mortality. Probabilistic exploration of the trial endpoints may enable greater understanding of the trial findings. We aimed to perform a reanalysis using a Bayesian framework. Methods We performed a secondary analysis of all 2927 patients randomized in multi-national STARRT-AKI trial, performed at 168 centers in 15 countries. The primary endpoint, 90-day all-cause mortality, was evaluated using hierarchical Bayesian logistic regression. A spectrum of priors includes optimistic, neutral, and pessimistic priors, along with priors informed from earlier clinical trials. Secondary endpoints (KRT-free days and hospital-free days) were assessed using zero–one inflated beta regression. Results The posterior probability of benefit comparing an accelerated versus a standard KRT initiation strategy for the primary endpoint suggested no important difference, regardless of the prior used (absolute difference of 0.13% [95% credible interval [CrI] − 3.30%; 3.40%], − 0.39% [95% CrI − 3.46%; 3.00%], and 0.64% [95% CrI − 2.53%; 3.88%] for neutral, optimistic, and pessimistic priors, respectively). There was a very low probability that the effect size was equal or larger than a consensus-defined minimal clinically important difference. Patients allocated to the accelerated strategy had a lower number of KRT-free days (median absolute difference of − 3.55 days [95% CrI − 6.38; − 0.48]), with a probability that the accelerated strategy was associated with more KRT-free days of 0.008. Hospital-free days were similar between strategies, with the accelerated strategy having a median absolute difference of 0.48 more hospital-free days (95% CrI − 1.87; 2.72) compared with the standard strategy and the probability that the accelerated strategy had more hospital-free days was 0.66. Conclusions In a Bayesian reanalysis of the STARRT-AKI trial, we found very low probability that an accelerated strategy has clinically important benefits compared with the standard strategy. Patients receiving the accelerated strategy probably have fewer days alive and KRT-free. These findings do not support the adoption of an accelerated strategy of KRT initiation.

Published
2022
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14. Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study

Author

Nisula, Sara, Kaukonen, Kirsi-Maija, Vaara, Suvi T., Korhonen, Anna-Maija, Poukkanen, Meri, Karlsson, Sari, Haapio, Mikko, Inkinen, Outi, Parviainen, Ilkka, Suojaranta-Ylinen, Raili, Laurila, Jouko J., Tenhunen, Jyrki, Reinikainen, Matti, Ala-Kokko, Tero, Ruokonen, Esko, Kuitunen, Anne, Pettilä, Ville, and The FINNAKI Study Group

Published
2013
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15. Common Inflammation-Related Candidate Gene Variants and Acute Kidney Injury in 2647 Critically Ill Finnish Patients

Author

Vilander, Laura M., Vaara, Suvi T., Kaunisto, Mari A., Pettilä, Ville, FINNAKI Study Grp, Laru-Sompa, Raili, Pulkkinen, Anni, Saarelainen, Minna, Reilama, Mikko, Tolmunen, Sinikka, Rantalainen, Ulla, Miettinen, Marja, Suvela, Markku, Pesola, Katrine, Saastamoinen, Pekka, Kauppinen, Sirpa, Kaukonen, Kirsi-Maija, Korhonen, Anna-Maija, Nisula, Sara, Vaara, Suvi, Suojaranta-Ylinen, Raili, Mildh, Leena, Haapio, Mikko, Nurminen, Laura, Sutinen, Sari, Pettilä, Leena, Laitinen, Helinä, Syrja, Heidi, Henttonen, Kirsi, Lappi, Elina, Boman, Hillevi, Varpula, Tero, Porkka, Päivi, Sivula, Mirka, Rahkonen, Mira, Tsurkka, Anne, Prittinen, Niina, Alaspaa, Ari, Salanto, Ville, Juntunen, Hanna, Sanisalo, Teija, Parviainen, Ilkka, Uusaro, Ari, Ruokonen, Esko, Bendel, Stepani, Rissanen, Niina, Lång, Maarit, Rahikainen, Sari, Rissanen, Saija, Ahonen, Merja, Halonen, Elina, Vaskelainen, Eija, Poukkanen, Meri, Lintula, Esa, Suominen, Sirpa, Heikkinen, Jorma, Lavander, Timo, Heinonen, Kirsi, Juopperi, Anne-Mari, Kaminski, Tadeusz, Gäddnäs, Fiia, Kuusela, Tuija, Roiko, Jane, Karlsson, Sari, Reinikainen, Matti, Surakka, Tero, Jyrkönen, Helena, Eiserbeck, Tanja, Kallinen, Jaana, Lund, Vesa, Tuominen, Päivi, Perkola, Pauliina, Tuominen, Riikka, Hietaranta, Marika, Johansson, Satu, Hovilehto, Seppo, Kirsi, Anne, Tiainen, Pekka, Myllärinen, Tuija, Leino, Pirjo, Toropainen, Anne, Kuitunen, Anne, Leppänen, Ilona, Levoranta, Markus, Hoppu, Sanna, Sauranen, Jukka, Tenhunen, Jyrki, Kukkurainen, Atte, Kortelainen, Samuli, Varila, Simo, Inkinen, Outi, Koivuviita, Niina, Kotamäki, Jutta, Laine, Anu, Ala-Kokko, Tero, Laurila, Jouko J., Sälkiö, Sinikka, Koivisto, Simo-Pekka, Hautamäki, Raku, Skinnar, Maria, Anestesiologian yksikkö, Clinicum, Department of Diagnostics and Therapeutics, University of Helsinki, HUS Perioperative, Intensive Care and Pain Medicine, Institute for Molecular Medicine Finland, Helsinki Institute of Life Science HiLIFE, Nefrologian yksikkö, Department of Medicine, HUS Abdominal Center, and HYKS erva

Subjects
medicine.medical_specialty, Candidate gene, ADVERSE OUTCOMES, lcsh:Medicine, human genetics, Genome-wide association study, Article, PROMOTER POLYMORPHISM, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Genetic model, Genetic predisposition, medicine, GENOME-WIDE ASSOCIATION, PLASMA-LEVELS, 030304 developmental biology, 0303 health sciences, SEPSIS, business.industry, MORTALITY, lcsh:R, Acute kidney injury, 1184 Genetics, developmental biology, physiology, NECROSIS-FACTOR-ALPHA, General Medicine, Odds ratio, medicine.disease, INTERLEUKIN-10, 3. Good health, acute kidney injury, 030220 oncology & carcinogenesis, 3121 General medicine, internal medicine and other clinical medicine, Cohort, genetic variation, ENDOTHELIAL GROWTH-FACTOR, RISK-FACTORS, business, Kidney disease
Abstract

Acute kidney injury (AKI) is a syndrome with high incidence among the critically ill. Because the clinical variables and currently used biomarkers have failed to predict the individual susceptibility to AKI, candidate gene variants for the trait have been studied. Studies about genetic predisposition to AKI have been mainly underpowered and of moderate quality. We report the association study of 27 genetic variants in a cohort of Finnish critically ill patients, focusing on the replication of associations detected with variants in genes related to inflammation, cell survival, or circulation. In this prospective, observational Finnish Acute Kidney Injury (FINNAKI) study, 2647 patients without chronic kidney disease were genotyped. We defined AKI according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria. We compared severe AKI (Stages 2 and 3, n = 625) to controls (Stage 0, n = 1582). For genotyping we used iPLEXTM Assay (Agena Bioscience). We performed the association analyses with PLINK software, using an additive genetic model in logistic regression. Despite the numerous, although contradictory, studies about association between polymorphisms rs1800629 in TNFA and rs1800896 in IL10 and AKI, we found no association (odds ratios 1.06 (95% CI 0.89–1.28, p = 0.51) and 0.92 (95% CI 0.80–1.05, p = 0.20), respectively). Adjusting for confounders did not change the results. To conclude, we could not confirm the associations reported in previous studies in a cohort of critically ill patients.

Published
2019

16. Erratum to: Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study

Author

Nisula, Sara, Kaukonen, Kirsi-Maija, Vaara, Suvi T., Korhonen, Anna-Maija, Poukkanen, Meri, Karlsson, Sari, Haapio, Mikko, Inkinen, Outi, Parviainen, Ilkka, Suojaranta-Ylinen, Raili, Laurila, Jouko J., Tenhunen, Jyrki, Reinikainen, Matti, Ala-Kokko, Tero, Ruokonen, Esko, Kuitunen, Anne, Pettilä, Ville, and The FINNAKI Study Group

Published
2013
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17. Association of oliguria with the development of acute kidney injury in the critically ill

Author

Vaara, Suvi T., primary, Parviainen, Ilkka, additional, Pettilä, Ville, additional, Nisula, Sara, additional, Inkinen, Outi, additional, Uusaro, Ari, additional, Laru-Sompa, Raili, additional, Pulkkinen, Anni, additional, Saarelainen, Minna, additional, Reilama, Mikko, additional, Tolmunen, Sinikka, additional, Rantalainen, Ulla, additional, Suvela, Markku, additional, Pesola, Katrine, additional, Saastamoinen, Pekka, additional, Kaukonen, Kirsi-Maija, additional, Korhonen, Anna-Maija, additional, Vaara, Suvi, additional, Suojaranta-Ylinen, Raili, additional, Mildh, Leena, additional, Haapio, Mikko, additional, Nurminen, Laura, additional, Sutinen, Sari, additional, Pettilä, Leena, additional, Laitinen, Helinä, additional, Syrjä, Heidi, additional, Henttonen, Kirsi, additional, Lappi, Elina, additional, Varpula, Tero, additional, Porkka, Päivi, additional, Sivula, Mirka, additional, Rahkonen, Mira, additional, Tsurkka, Anne, additional, Nieminen, Taina, additional, Alaspää, Ari, additional, Salanto, Ville, additional, Juntunen, Hanna, additional, Ruokonen, Esko, additional, Bendel, Stepani, additional, Rissanen, Niina, additional, Lång, Maarit, additional, Rahikainen, Sari, additional, Rissanen, Saija, additional, Ahonen, Merja, additional, Halonen, Elina, additional, Poukkanen, Meri, additional, Lintula, Esa, additional, Heikkinen, Jorma, additional, Lavander, Timo, additional, Heinonen, Kirsi, additional, Kaminski, Tadeusz, additional, Gäddnäs, Fiia, additional, Kuusela, Tuija, additional, Karlsson, Sari, additional, Reinikainen, Matti, additional, Surakka, Tero, additional, Jyrkönen, Helena, additional, Eiserbeck, Tanja, additional, Ala-Kokko, Tero, additional, Laurila, Jouko, additional, Lund, Vesa, additional, Tuominen, Päivi, additional, Perkola, Pauliina, additional, Tuominen, Riikka, additional, Hietaranta, Marika, additional, Hovilehto, Seppo, additional, Kirsi, Anne, additional, Tiainen, Pekka, additional, Myllärinen, Tuija, additional, Leino, Pirjo, additional, Kuitunen, Anne, additional, Tenhu-nen, Jyrki, additional, Leppänen, Ilona, additional, Levoranta, Markus, additional, Hoppu, Sanna, additional, Sauranen, Jukka, additional, Kukkurainen, Atte, additional, Kortelainen, Samuli, additional, Koivuviita, Niina, additional, Kotamäki, Jutta, additional, Koivisto, Simo-Pekka, additional, Hautamäki, Raku, additional, and Skinnar, Maria, additional

Published
2016
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18. Predictive value of urine interleukin-18 in the evolution and outcome of acute kidney injury in critically ill adult patients

Author

Nisula, S., primary, Yang, R., additional, Poukkanen, M., additional, Vaara, S.T., additional, Kaukonen, K.M., additional, Tallgren, M., additional, Haapio, M., additional, Tenhunen, J., additional, Korhonen, A.M., additional, Pettilä, V., additional, Laru-Sompa, Raili, additional, Pulkkinen, Anni, additional, Saarelainen, Minna, additional, Reilama, Mikko, additional, Tolmunen, Sinikka, additional, Rantalainen, Ulla, additional, Miettinen, Marja, additional, Suvela, Markku, additional, Pesola, Katrine, additional, Saastamoinen, Pekka, additional, Kauppinen, Sirpa, additional, Pettilä, Ville, additional, Kaukonen, Kirsi-Maija, additional, Korhonen, Anna-Maija, additional, Nisula, Sara, additional, Vaara, Suvi, additional, Suojaranta-Ylinen, Raili, additional, Mildh, Leena, additional, Haapio, Mikko, additional, Nurminen, Laura, additional, Sutinen, Sari, additional, Pettilä, Leena, additional, Laitinen, Helinä, additional, Syrjä, Heidi, additional, Henttonen, Kirsi, additional, Lappi, Elina, additional, Boman, Hillevi, additional, Varpula, Tero, additional, Porkka, Päivi, additional, Mira Rahkonen, Mirka Sivula, additional, Tsurkka, Anne, additional, Nieminen, Taina, additional, Prittinen, Niina, additional, Alaspää, Ari, additional, Salanto, Ville, additional, Juntunen, Hanna, additional, Sanisalo, Teija, additional, Parviainen, Ilkka, additional, Uusaro, Ari, additional, Ruokonen, Esko, additional, Bendel, Stepani, additional, Rissanen, Niina, additional, Lång, Maarit, additional, Rahikainen, Sari, additional, Rissanen, Saija, additional, Ahonen, Merja, additional, Halonen, Elina, additional, Vaskelainen, Eija, additional, Poukkanen, Meri, additional, Lintula, Esa, additional, Suominen, Sirpa, additional, Heikkinen, Jorma, additional, Lavander, Timo, additional, Heinonen, Kirsi, additional, Juopperi, Anne-Mari, additional, Kaminski, Tadeusz, additional, Gäddnäs, Fiia, additional, Kuusela, Tuija, additional, Roiko, Jane, additional, Karlsson, Sari, additional, Reinikainen, Matti, additional, Surakka, Tero, additional, Jyrkönen, Helena, additional, Eiserbeck, Tanja, additional, Kallinen, Jaana, additional, Lund, Vesa, additional, Tuominen, Päivi, additional, Perkola, Pauliina, additional, Tuominen, Riikka, additional, Hietaranta, Marika, additional, Johansson, Satu, additional, Hovilehto, Seppo, additional, Kirsi, Anne, additional, Tiainen, Pekka, additional, Myllärinen, Tuija, additional, Leino, Pirjo, additional, Toropainen, Anne, additional, Kuitunen, Anne, additional, Leppänen, Ilona, additional, Levoranta, Markus, additional, Hoppu, Sanna, additional, Sauranen, Jukka, additional, Tenhunen, Jyrki, additional, Kukkurainen, Atte, additional, Kortelainen, Samuli, additional, Varila, Simo, additional, Inkinen, Outi, additional, Koivuviita, Niina, additional, Kotamäki, Jutta, additional, Laine, Anu, additional, Ala-Kokko, Tero, additional, Laurila, Jouko, additional, Sälkiö, Sinikka, additional, Koivisto, Simo-Pekka, additional, Hautamäki, Raku, additional, and Skinnar, Maria, additional

Published
2015
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19. Six-month survival and quality of life of intensive care patients with acute kidney injury.

Author

Nisula, Sara, Vaara, Suvi T., Kaukonen, Kirsi-Maija, Reinikainen, Matti, Koivisto, Simo-Pekka, Inkinen, Outi, Poukkanen, Meri, Tiainen, Pekka, Pettilä, Ville, and Korhonen, Anna-Maija

Subjects
QUALITY of life, KIDNEY injuries, INTENSIVE care patients, CONFIDENCE intervals, GLOMERULAR filtration rate
Abstract

Introduction Acute kidney injury (AKI) has high incidence among the critically ill and associates with dismal outcome. Not only the long-term survival, but also the quality of life (QOL) of patients with AKI is relevant due to substantial burden of care regarding these patients. We aimed to study the long-term outcome and QOL of patients with AKI treated in intensive care units. Methods We conducted a predefined six-month follow-up of adult intensive care unit (ICU) patients from the prospective, observational, multi-centre FINNAKI study. We evaluated the QOL of survivors with the EuroQol (EQ-5D) questionnaire. We included all participating sites with at least 70% rate of QOL measurements in the analysis. Results Of the 1568 study patients, 635 [40.5%, 95% confidence interval (CI) 38.0-43.0%] had AKI according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria. Of the 635 AKI patients, 224 (35.3%), as compared to 154/933 (16.5%) patients without AKI, died within six months. Of the 1190 survivors, 959 (80.6%) answered the EQ-5D questionnaire at six months. The QOL (median with IQR) measured with the EQ-5D index and compared to age- and sex-matched general population was: 0.676 (0.520-1.00) vs. 0.826 (0.812-0.859) for AKI patients, and 0.690 (0.533-1.00) vs. 0.845 (0.812-0.882) for patients without AKI (P < 0.001 in both). The EQ-5D at the time of ICU admission was available for 774 (80.7%) of the six-month respondents. We detected a mean increase of 0.017 for non-AKI and of 0.024 for AKI patients in the EQ-5D index (P = 0.728). The EQ-5D visual analogue scores (median with IQR) of patients with AKI [70 (50-83)] and patients without AKI [75 (60-87)] were not different from the age- and sex-matched general population [69 (68-73) and 70 (68-77)]. Conclusions The health-related quality of life of patients with and without AKI was already lower on ICU admission than that of the age- and sex-matched general population, and did not change significantly during critical illness. Patients with and without AKI rate their subjective health to be as good as age and sex-matched general population despite statistically significantly lower QOL indexes measured by EQ-5D. [ABSTRACT FROM AUTHOR]

Published
2013
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20. Hemodynamic variables and progression of acute kidney injury in critically ill patients with severe sepsis: data from the prospective observational FINNAKI study.

Author

Poukkanen, Meri, Wilkman, Erika, Vaara, Suvi T., Pettilä, Ville, Kaukonen, Kirsi-Maija, Korhonen, Anna-Maija, Uusaro, Ari, Hovilehto, Seppo, Inkinen, Outi, Laru-Sompa, Raili, Hautamäki, Raku, Kuitunen, Anne, and Karlsson, Sari

Subjects
ACUTE kidney failure, HEMODYNAMICS, CRITICALLY ill, SEPSIS, DISEASE progression, DOBUTAMINE, LONGITUDINAL method
Abstract

Introduction Knowledge of the association of hemodynamics with progression of septic acute kidney injury (AKI) is limited. However, some recent data suggest that mean arterial pressure (MAP) exceeding current guidelines (60-65 mmHg) may be needed to prevent AKI. We hypothesized that higher MAP during the first 24 hours in the intensive care unit (ICU), would be associated with a lower risk of progression of AKI in patients with severe sepsis. Methods We identified 423 patients with severe sepsis and electronically recorded continuous hemodynamic data in the prospective observational FINNAKI study. The primary endpoint was progression of AKI within the first 5 days of ICU admission defined as new onset or worsening of AKI by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. We evaluated the association of hemodynamic variables with this endpoint. We included 53724 10-minute medians of MAP in the analysis. We analysed the ability of time-adjusted MAP to predict progression of AKI by receiver operating characteristic (ROC) analysis. Results Of 423 patients, 153 (36.2%) had progression of AKI. Patients with progression of AKI had significantly lower time-adjusted MAP, 74.4 mmHg [68.3-80.8], than those without progression, 78.6 mmHg [72.9-85.4], P < 0.001. A cut-off value of 73 mmHg for time-adjusted MAP best predicted the progression of AKI. Chronic kidney disease, higher lactate, higher dose of furosemide, use of dobutamine and time-adjusted MAP below 73 mmHg were independent predictors of progression of AKI. Conclusions The findings of this large prospective multicenter observational study suggest that hypotensive episodes (MAP under 73 mmHg) are associated with progression of AKI in critically ill patients with severe sepsis. [ABSTRACT FROM AUTHOR]

Published
2013
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21. Fluid overload is associated with an increased risk for 90-day mortality in critically ill patients with renal replacement therapy: data from the prospective FINNAKI study.

Author

Vaara, Suvi T, Korhonen, Anna-Maija, Kaukonen, Kirsi-Maija, Nisula, Sara, Inkinen, Outi, Hoppu, Sanna, Laurila, Jouko J, Mildh, Leena, Reinikainen, Matti, Lund, Vesa, Parviainen, Ilkka, and Pettilä, Ville

Subjects
CRITICALLY ill, KIDNEY injuries, INTENSIVE care units, MORTALITY, CRITICAL care medicine, MEDICINE
Abstract

Introduction: Positive fluid balance has been associated with an increased risk for mortality in critically ill patients with acute kidney injury with or without renal replacement therapy (RRT). Data on fluid accumulation prior to RRT initiation and mortality are limited. We aimed to study the association between fluid accumulation at RRT initiation and 90-day mortality. Methods: We conducted a prospective, multicenter, observational cohort study in 17 Finnish intensive care units (ICUs) during a five-month period. We collected data on patient characteristics, RRT timing, and parameters at RRT initiation. We studied the association of parameters at RRT initiation, including fluid overload (defined as cumulative fluid accumulation > 10% of baseline weight) with 90-day mortality. Results: We included 296 RRT-treated critically ill patients. Of 283 patients with complete data on fluid balance, 76 (26.9%) patients had fluid overload. The median (interquartile range) time from ICU admission to RRT initiation was 14 (3.3 to 41.5) hours. The 90-day mortality rate of the whole cohort was 116 of 296 (39.2%; 95% confidence interval 38.6 to 39.8%). The crude 90-day mortality of patients with or without fluid overload was 45 of 76 (59.2%) vs. 65 of 207 (31.4%), P < 0.001. In logistic regression, fluid overload was associated with an increased risk for 90-day mortality (odds ratio 2.6) after adjusting for disease severity, time of RRT initiation, initial RRT modality, and sepsis. Of the 168 survivors with data on RRT use at 90 days, 34 (18.9%, 95% CI 13.2 to 24.6%) were still dependent on RRT. Conclusions: Patients with fluid overload at RRT initiation had twice as high crude 90-day mortality compared to those without. Fluid overload was associated with increased risk for 90-day mortality even after adjustments. [ABSTRACT FROM AUTHOR]

Published
2012
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22. MOESM1 of Association of endothelial and glycocalyx injury biomarkers with fluid administration, development of acute kidney injury, and 90-day mortality: data from the FINNAKI observational study

Author

Inkinen, Nina, Pettilä, Ville, PäIvi Lakkisto, Kuitunen, Anne, Jukarainen, Sakari, Stepani Bendel, Inkinen, Outi, Ala-Kokko, Tero, and Vaara, Suvi

Subjects
3. Good health
Abstract

Additional file 1: Figure S1. Flow chart. Table S1. Biomarker levels and chronic diseases. Figure S2. Sequential samples subanalysis including 40 patients with biomarkers measured every 12hrs until 36 hrs. Table S2. Correlation between biomarkers. Table S3. Multivariable linear regression models predicting log Fluid input on Day 0 normalized to hours. Table S4. Multivariable linear regression models predicting Cumulative balance %/weight. TableS5. Biomarker levels and acute kidney injury.

23. MOESM1 of Association of endothelial and glycocalyx injury biomarkers with fluid administration, development of acute kidney injury, and 90-day mortality: data from the FINNAKI observational study

Author

Inkinen, Nina, Pettilä, Ville, PäIvi Lakkisto, Kuitunen, Anne, Jukarainen, Sakari, Stepani Bendel, Inkinen, Outi, Ala-Kokko, Tero, and Vaara, Suvi

Subjects
3. Good health
Abstract

Additional file 1: Figure S1. Flow chart. Table S1. Biomarker levels and chronic diseases. Figure S2. Sequential samples subanalysis including 40 patients with biomarkers measured every 12hrs until 36 hrs. Table S2. Correlation between biomarkers. Table S3. Multivariable linear regression models predicting log Fluid input on Day 0 normalized to hours. Table S4. Multivariable linear regression models predicting Cumulative balance %/weight. TableS5. Biomarker levels and acute kidney injury.

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