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1. Management of colorectal high-grade dysplasia or cancer resected by cold snare polypectomy: a multicenter exploratory study

Author

Inoki, Kazuya, Takamaru, Hiroyuki, Furuhashi, Hiroto, Kishida, Yoshihiro, Shimodate, Yuichi, Sumida, Yorinobu, Hosotani, Kazuya, Ueyama, Hiroya, Furumoto, Yohei, Hashimoto, Shinichi, Takeuchi, Yoji, Ichijima, Ryoji, Yoshizawa, Yashiro, Suzuki, Takuto, Minoda, Yosuke, Mizukami, Kazuhiro, Matsumura, Tomoaki, Kasai, Toyotaka, Yamamura, Takeshi, Ohnita, Ken, Hara, Ken, Esaki, Mitsuru, Katagiri, Atsushi, Ishikawa, Hideki, and Gotoda, Takuji

Published
2023
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3. News in ESD

Author

Inoki, Kazuya, Matsuda, Takahisa, Saito, Yutaka, Conigliaro, Rita, editor, and Frazzoni, Marzio, editor

Published
2017
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5. The effectiveness of bile cytology during percutaneous transhepatic gallbladder drainage for acute cholecystitis in diagnosing incidental gallbladder cancer

Author

USAMI, Tomono, INOKI, Kazuya, ISHII, Yui, MITSUI, Yuta, OIKAWA, Shu, NISHIHARA, Shigetoshi, NAKATANI, Kei, NAKAYAMA, Akihiro, NOGUCHI, Toshihiro, and YOSHIDA, Hitoshi

Abstract

Incidental gallbladder cancers （IGBCs） refer to gallbladder cancers （GCs） that are not preoperatively diagnosed but are diagnosed only after cholecystectomy for benign gallbladder diseases. This exploratory study aimed to investigate the diagnostic performance of bile cytology with percutaneous transhepatic gallbladder drainage （PTGBD） and tumor markers in preoperatively detecting IGBC. Data on consecutive acute cholecystitis cases between January 2018 and March 2020 at the Showa University Hospital in Tokyo, Japan, were retrospectively analyzed. Patient characteristics, bile cytology results, collection date, and blood test results were assessed. Concerning the bile cytology results, classes I–III were categorized as negative, whereas classes IV and V were positive. Bile cytology was performed in 102 patients; of these, 2 cases were diagnosed as GC. The bile cytology results were as follows: class I in 15 cases; class II in 84; class III in 2; class IV in 1; and class V in 0. Therefore, 101 and 1 cases were judged as negative and positive, respectively. Bile cytology had a sensitivity of 50％, specificity of 100％, positive predictive value of 100％, and negative predictive value of 99％. Among 47 patients in whom carcinoembryonic antigen （CEA） and carbohydrate antigen 19-9 （CA19-9） levels were measured, 3 and 12 patients exhibited elevated CEA and CA19-9 levels, respectively. Tumor markers were elevated in IGBC cases; however, several false-positive results were present in cases without GC. Bile cytology from PTGBD may be useful for the preoperative diagnosis of IGBC with acute cholecystitis. Measurement of CEA and CA19-9 levels as tumor markers should be performed with caution, as false-positive results due to inflammation would be included.

Published
2022

6. PREDICTORS FOR DIFFICULTIES OR FAILURES OF ENDOSCOPIC SUBMUCOSAL DISSECTION FOR COLORECTAL NEOPLASMS: A MULTICENTER STUDY

Author

Esaki, Mitsuru, primary, Ichijima, Ryoji, additional, Sumida, Yorinobu, additional, Inada, Taisuke, additional, Nemoto, Daiki, additional, Nakajima, Yuki, additional, Minagawa, Takeyoshi, additional, Sumiyoshi, Tetsuya, additional, Inoki, Kazuya, additional, Yoshida, Naohisa, additional, Inoue, Ken, additional, Fukuzawa, Masakatsu, additional, Minoda, Yosuke, additional, Tsutsumi, Koshiro, additional, Maehara, Kosuke, additional, Ihara, Eikichi, additional, Akiho, Hirotada, additional, and Gotoda, Takuji, additional

Published
2023
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7. The effectiveness of bile cytology during percutaneous transhepatic gallbladder drainage for acute cholecystitis in diagnosing incidental gallbladder cancer

Author

USAMI, Tomono, INOKI, Kazuya, ISHII, Yui, MITSUI, Yuta, OIKAWA, Shu, NISHIHARA, Shigetoshi, NAKATANI, Kei, NAKAYAMA, Akihiro, NOGUCHI, Toshihiro, YOSHIDA, Hitoshi, USAMI, Tomono, INOKI, Kazuya, ISHII, Yui, MITSUI, Yuta, OIKAWA, Shu, NISHIHARA, Shigetoshi, NAKATANI, Kei, NAKAYAMA, Akihiro, NOGUCHI, Toshihiro, and YOSHIDA, Hitoshi

Abstract

Incidental gallbladder cancers （IGBCs） refer to gallbladder cancers （GCs） that are not preoperatively diagnosed but are diagnosed only after cholecystectomy for benign gallbladder diseases. This exploratory study aimed to investigate the diagnostic performance of bile cytology with percutaneous transhepatic gallbladder drainage （PTGBD） and tumor markers in preoperatively detecting IGBC. Data on consecutive acute cholecystitis cases between January 2018 and March 2020 at the Showa University Hospital in Tokyo, Japan, were retrospectively analyzed. Patient characteristics, bile cytology results, collection date, and blood test results were assessed. Concerning the bile cytology results, classes I–III were categorized as negative, whereas classes IV and V were positive. Bile cytology was performed in 102 patients; of these, 2 cases were diagnosed as GC. The bile cytology results were as follows: class I in 15 cases; class II in 84; class III in 2; class IV in 1; and class V in 0. Therefore, 101 and 1 cases were judged as negative and positive, respectively. Bile cytology had a sensitivity of 50％, specificity of 100％, positive predictive value of 100％, and negative predictive value of 99％. Among 47 patients in whom carcinoembryonic antigen （CEA） and carbohydrate antigen 19-9 （CA19-9） levels were measured, 3 and 12 patients exhibited elevated CEA and CA19-9 levels, respectively. Tumor markers were elevated in IGBC cases; however, several false-positive results were present in cases without GC. Bile cytology from PTGBD may be useful for the preoperative diagnosis of IGBC with acute cholecystitis. Measurement of CEA and CA19-9 levels as tumor markers should be performed with caution, as false-positive results due to inflammation would be included.

Published
2023

8. Submucosal Injection Using Epinephrine-Added Saline in Cold Snare Polypectomy for Colorectal Polyps Shortens Time Required for Resection: A Randomized Controlled Study

Author

Katagiri, Atsushi, primary, Suzuki, Norihiro, additional, Nakatani, Shinya, additional, Kikuchi, Kazuo, additional, Fujiwara, Takahisa, additional, Gocho, Toshihiko, additional, Konda, Kenichi, additional, Inoki, Kazuya, additional, Yamamura, Fuyuhiko, additional, and Yoshida, Hitoshi, additional

Published
2023
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9. Factors associated with endoscopic treatment decisions for T1b or more deeply invading colorectal cancers

Author

NAKATANI, Shinya, KATAGIRI, Atsushi, SUZUKI, Norihiro, KIKUCHI, Kazuo, YANAGISAWA, Fumito, GOCHO, Toshihiko, INOKI, Kazuya, KONDA, Kenichi, YAMAMURA, Fuyuhiko, INOUE, Eisuke, and YOSHIDA, Hitoshi

Abstract

Surgical resection for colorectal cancer（CRC）that deeply invades the submucosa（≥1,000µm）（T1b）has been recommended to reduce the potential risk of lymph node metastasis. In clinical settings, cases of pathological T1b exist, and these cases are treated with endoscopic resection（ER）for various reasons. However, factors that influence the choice of ER to treat T1b CRC remain unknown. Therefore, in this study, we investigated the factors associated with the choice of endoscopic treatments in patients diagnosed with pathological T1b or a more deeply invading CRC. To achieve this aim, we conducted a case series investigation of the previously conducted endoscopic diagnoses, after which we selected treatments for colorectal lesions. The case series comprised 83 lesions endoscopically diagnosed as early CRC, which was subsequently reviewed by eight endoscopists with various levels of experience in magnifying colonoscopy at Showa University Hospital. Then, pathological T1b or T2 lesions were extracted from the case series. We also assessed factors related to ER selection for these lesions using multiple logistic regression and analyzed their contributions using decision tree analysis. Eighteen cases with pathological T1b or more deeply invading lesions were extracted, and the analyses were conducted using 144 data obtained from these 18 lesions as interpreted by the eight reviewers. With multivariate logistic regression, a low estimation level for T1b and high confidence to perform ER were identified as independent factors affecting the selection of ER for T1b. The decision tree analysis further indicated that confidence levels to perform ER influenced treatment selection, especially in lesions diagnosed as probable T1b. Our study therefore demonstrated that factors affecting the selection of ER to treat T1b CRCs were low estimations during endoscopic diagnosis and high confidence to conduct the ER procedure.

Published
2021

11. Endoscopic closure of a postoperative enterocutaneous fistula using an over-the-scope-clip (OTSC) system

Author

Mori, Daichi, primary, Inoki, Kazuya, additional, Higuchi, Kensuke, additional, Suzuki, Norihiro, additional, Kikuchi, Kazuo, additional, Nakatani, Shinya, additional, Fujiwara, Takahisa, additional, Gochou, Toshihiko, additional, Yanagisawa, Fumito, additional, Konda, Kenichi, additional, Tojo, Masayuki, additional, Katagiri, Atushi, additional, Yamamura, Fuyuhiko, additional, Aoki, Takeshi, additional, and Yoshida, Hitoshi, additional

Published
2022
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12. Randomized controlled trial comparing conventional and traction endoscopic submucosal dissection for early colon tumor ( CONNECT‐C trial)

Author

Ichijima, Ryoji, primary, Ikehara, Hisatomo, additional, Sumida, Yorinobu, additional, Inada, Taisuke, additional, Nemoto, Daiki, additional, Nakajima, Yuki, additional, Minagawa, Takeyoshi, additional, Sumiyoshi, Tetsuya, additional, Inoki, Kazuya, additional, Yoshida, Naohisa, additional, Inoue, Ken, additional, Fukuzawa, Masakatsu, additional, Minoda, Yosuke, additional, Tsutsumi, Koshiro, additional, Esaki, Mitsuru, additional, and Gotoda, Takuji, additional

Published
2022
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13. Reduced Intravenous Fluorescein Dose for Upper and Lower Gastrointestinal Tract Probe-Based Confocal Laser Endomicroscopy

Author

Inoki, Kazuya, Abe, Seiichiro, Tanaka, Yusaku, Yamamoto, Koji, Hihara, Daisuke, Ichijima, Ryoji, Nakatani, Yukihiro, Chen, HsinYu, Takamaru, Hiroyuki, Sekiguchi, Masau, Yamada, Masayoshi, Sakamoto, Taku, Nonaka, Satoru, Suzuki, Haruhisa, Yoshinaga, Shigetaka, Oda, Ichiro, Matsuda, Takahisa, and Saito, Yutaka

Subjects
medicine.medical_specialty, Duodenum, Medicine (miscellaneous), RC799-869, Gastroenterology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Lower gastrointestinal tract, Medicine, Radiology, Nuclear Medicine and imaging, Fluorescein, Confocal laser endomicroscopy, Lower Gastrointestinal Tract, medicine.diagnostic_test, business.industry, Stomach, Endoscopy, Diseases of the digestive system. Gastroenterology, Reduced dose, medicine.disease, RC31-1245, medicine.anatomical_structure, chemistry, Dysplasia, 030220 oncology & carcinogenesis, Original Article, 030211 gastroenterology & hepatology, business
Abstract

Background/aims Probe-based confocal laser endomicroscopy (pCLE) requires the administration of intravenous (IV) fluorescein. This study aimed to determine the optimal dose of IV fluorescein for both upper and lower gastrointestinal (GI) tract pCLE. Methods Patients 20 to 79 years old with gastric high-grade dysplasia (HGD) or colorectal neoplasms (CRNs) were enrolled in the study. The dose de-escalation method was employed with five levels. The primary endpoint of the study was the determination of the optimal dose of IV fluorescein for pCLE of the GI tract. The reduced dose was determined based on off-line reviews by three endoscopists. An insufficient dose of fluorescein was defined as the dose of fluorescein with which the pCLE images were not deemed to be visible. If all three endoscopists determined that the tissue structure was visible, the doses were de-escalated. Results A total of 12 patients with gastric HGD and 12 patients with CRNs were enrolled in the study. Doses were de-escalated to 0.5 mg/kg of fluorescein for both non-neoplastic duodenal and colorectal mucosa. All gastric HGD or CRNs were visible with pCLE with IV fluorescein at 0.5 mg/kg. Conclusions In the present study, pCLE with IV fluorescein 0.5 mg/kg was adequate to visualize the magnified structure of both the upper and lower GI tract.

Published
2021
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14. Small intestinal bleeding and stricture caused by Meckel's diverticulum

Author

Nakatani, Shinya, primary, Inoki, Kazuya, additional, Tashiro, Tomoe, additional, Yamaguchi, Sayaka, additional, Gocho, Toshihiko, additional, Yanagisawa, Fumito, additional, Konda, Kenichi, additional, Tojo, Masayuki, additional, Kubota, Yutaro, additional, Katagiri, Atsushi, additional, Yamamura, Fuyuhiko, additional, Takeuchi, Yoshiaki, additional, Tate, Genshu, additional, Komoto, Masahiro, additional, Yamazaki, Kimiyasu, additional, Murakami, Masahiko, additional, and Yoshida, Hitoshi, additional

Published
2022
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15. A RANDOMIZED CONTROLLED TRIAL OF CONVENTIONAL ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) AND TRACTION ESD FOR COLORECTAL TUMORS

Author

Inada, Taisuke, primary, Sumida, Yorinobu, additional, Ichijima, Ryoji, additional, Ikehara, Hisatomo, additional, Nakajima, Yuki, additional, Nemoto, Daiki, additional, Minagawa, Takeyoshi, additional, Sumiyoshi, Tetsuya, additional, Inoki, Kazuya, additional, Inoue, Ken, additional, Yoshida, Naohisa, additional, Fukuzawa, Masakatsu, additional, Minoda, Yosuke, additional, Tsutsumi, Koshiro, additional, Esaki, Mitsuru, additional, and Gotoda, Takuji, additional

Published
2022
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16. Gastrointestinal Endoscopy for Patients with High Levels of Serum CEA and CA19-9

Author

SUZUKI, Norihiro, KATAGIRI, Atsushi, NAKATANI, Shinya, KIKUCHI, Kazuo, GOCHO, Toshihiko, YANAGISAWA, Fumito, INOKI, Kazuya, KONDA, Kenichi, TOJO, Masayuki, KUBOTA, Yutaro, KONISHI, Kazuo, YAMAMURA, Fuyuhiko, and YOSHIDA, Hitoshi

Subjects
endocrine system diseases, digestive system diseases
Abstract

Serum levels of tumor markers, such as carcinoembryonic antigen （CEA） and carbohydrate antigen 19-9 （CA19-9）, are often measured to detect potential malignancy. When these levels are high, the presence or absence of malignancy is confirmed via a more detailed examination using gastrointestinal （GI） endoscopy and computed tomography. The rate of confirmation of malignancy upon such a follow-up is unknown. This study aimed to investigate the malignancy detection rate via GI endoscopy for patients with high levels of serum CEA and CA19-9. All patients who underwent such GI endoscopy between January 2018 and February 2019 at Showa University Hospital were included in this study. The patients were divided into a follow-up group and a screening group, depending on the purpose of measuring their serum CEA/CA19-9 levels. There were 156 patients who underwent GI endoscopy because of high CEA/CA19-9 levels within the study period. Advanced malignant lesions were detected in 10 patients （6.4％）, including seven cases of colorectal cancer and three cases of upper GI malignancies. In the screening group, six cases （5.7％） of GI malignancies were detected, none of which were found in asymptomatic patients without anemia. In the follow-up group, four cases （7.8％） of GI malignancies were detected; three patients were asymptomatic, and one patient had anemia. Our findings suggest that high serum CEA/CA19-9 levels in asymptomatic patients without anemia and without a history of malignancy do not indicate the presence of malignancy. However, high serum CEA/CA19-9 levels may indicate the potential presence of GI malignancies for patients with a history of malignant tumors, even if they are asymptomatic and do not have anemia.

Published
2020

17. Factors associated with endoscopic treatment decisions for T1b or more deeply invading colorectal cancers

Author

NAKATANI, Shinya, KATAGIRI, Atsushi, SUZUKI, Norihiro, KIKUCHI, Kazuo, YANAGISAWA, Fumito, GOCHO, Toshihiko, INOKI, Kazuya, KONDA, Kenichi, YAMAMURA, Fuyuhiko, INOUE, Eisuke, YOSHIDA, Hitoshi, NAKATANI, Shinya, KATAGIRI, Atsushi, SUZUKI, Norihiro, KIKUCHI, Kazuo, YANAGISAWA, Fumito, GOCHO, Toshihiko, INOKI, Kazuya, KONDA, Kenichi, YAMAMURA, Fuyuhiko, INOUE, Eisuke, and YOSHIDA, Hitoshi

Abstract

Surgical resection for colorectal cancer（CRC）that deeply invades the submucosa（≥1,000µm）（T1b）has been recommended to reduce the potential risk of lymph node metastasis. In clinical settings, cases of pathological T1b exist, and these cases are treated with endoscopic resection（ER）for various reasons. However, factors that influence the choice of ER to treat T1b CRC remain unknown. Therefore, in this study, we investigated the factors associated with the choice of endoscopic treatments in patients diagnosed with pathological T1b or a more deeply invading CRC. To achieve this aim, we conducted a case series investigation of the previously conducted endoscopic diagnoses, after which we selected treatments for colorectal lesions. The case series comprised 83 lesions endoscopically diagnosed as early CRC, which was subsequently reviewed by eight endoscopists with various levels of experience in magnifying colonoscopy at Showa University Hospital. Then, pathological T1b or T2 lesions were extracted from the case series. We also assessed factors related to ER selection for these lesions using multiple logistic regression and analyzed their contributions using decision tree analysis. Eighteen cases with pathological T1b or more deeply invading lesions were extracted, and the analyses were conducted using 144 data obtained from these 18 lesions as interpreted by the eight reviewers. With multivariate logistic regression, a low estimation level for T1b and high confidence to perform ER were identified as independent factors affecting the selection of ER for T1b. The decision tree analysis further indicated that confidence levels to perform ER influenced treatment selection, especially in lesions diagnosed as probable T1b. Our study therefore demonstrated that factors affecting the selection of ER to treat T1b CRCs were low estimations during endoscopic diagnosis and high confidence to conduct the ER procedure.

Published
2022

18. A case of infectious gastritis in an immunosuppressed patient

Author

Gocho, Toshihiko, primary, Konda, Kenichi, additional, Suzuki, Norihiro, additional, Nakatani, Shinya, additional, Yanagisawa, Fumito, additional, Tagawa, Teppei, additional, Inoki, Kazuya, additional, Kihara, Toshihiro, additional, Yano, Yuichiro, additional, Kubota, Yutaro, additional, Katagiri, Atsushi, additional, Yamamura, Fuyuhiko, additional, and Yoshida, Hitoshi, additional

Published
2021
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19. Randomized controlled trial comparing conventional and traction endoscopic submucosal dissection for early colon tumor (CONNECT‐C trial).

Author

Ichijima, Ryoji, Ikehara, Hisatomo, Sumida, Yorinobu, Inada, Taisuke, Nemoto, Daiki, Nakajima, Yuki, Minagawa, Takeyoshi, Sumiyoshi, Tetsuya, Inoki, Kazuya, Yoshida, Naohisa, Inoue, Ken, Fukuzawa, Masakatsu, Minoda, Yosuke, Tsutsumi, Koshiro, Esaki, Mitsuru, and Gotoda, Takuji

Subjects
RANDOMIZED controlled trials, COLON tumors, SUBMUCOUS plexus, GASTROINTESTINAL cancer, DISSECTION
Abstract

Objectives: Endoscopic submucosal dissection (ESD) is a widely used treatment for early gastrointestinal cancer. However, colon ESD remains challenging. Previous studies on colon ESD using the traction method used a small sample, single‐center design, providing insufficient evidence of this procedure's efficacy. We thus aimed to investigate the efficacy and safety of the traction method in colon ESD in this multicenter randomized trial. Methods: We conducted a prospective, multicenter, randomized, two‐arm controlled trial at 10 facilities in Japan. A 1:1 allocation was conducted for the conventional ESD (C‐ESD) and traction ESD (T‐ESD) groups. The primary end‐point was ESD procedure time. Results: We included 128 C‐ESD and 123 T‐ESD cases from April 2020 to August 2021. The median procedure times for C‐ESD and T‐ESD were 61 (40–100) and 53 (40–76) min (P = 0.18), respectively, and no significant differences were observed between the groups. Subgroup analysis showed that the median procedure times for patients with a lesion diameter of ≥30 mm in the C‐ESD and T‐ESD groups were 89 (57−80) and 69 (50−104) min (P = 0.05), respectively, and for nonexpert operators were 81 (62−120) and 64 (52−109) min (P = 0.07), respectively. Conclusions: The traction method did not contribute to a significantly shortened ESD procedure time. However, this method may be useful when the tumor diameter is large or if the procedure is conducted by nonexpert endoscopists. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Simultaneous Small Intestinal Bleeding and Stricture Caused by Meckel's Diverticulum

Author

Nakatani, Shinya, primary, Inoki, Kazuya, additional, Tashiro, Tomoe, additional, Yamaguchi, Sayaka, additional, Gocho, Toshihiko, additional, Yanagisawa, Fumito, additional, Konda, Kenichi, additional, Tojo, Masayuki, additional, Kubota, Yutaro, additional, Katagiri, Atsushi, additional, Yamamura, Fuyuhiko, additional, Takeuchi, Yoshiaki, additional, Tate, Genshu, additional, Komoto, Masahiro, additional, Yamazaki, Kimiyasu, additional, Murakami, Masahiko, additional, and Yoshida, Hitoshi, additional

Published
2020
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25. SUBMUCOSAL INJECTION USING EPINEPHRINE-ADDED SALINE IN COLD SNARE POLYPECTOMY FOR COLORECTAL POLYPS SAVES THE TIME REQUIRED FOR RESECTION: A RANDOMIZED CONTROLLED STUDY

Author

Katagiri, Atsushi, Higuchi, Keusuke, Suzuki, Norihiro, Nakatani, Shinya, Kikuchi, Kazuo, Gocho, Toshihiko, Fujiwara, Takahisa, Yanagisawa, Fumito, Inoki, Kazuya, Konda, Kenichi, Tojo masayuki, Uozumi, Shojiro, Kubota, Yutaro, Yamamura, Fuyuhiko, Konishi, Kazuo, and Yoshida, Hitoshi

Published
2022
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27. Capsule Endoscopy after Hematopoietic Stem Cell Transplantation Can Predict Transplant-Related Mortality

Author

Inoki, Kazuya, primary, Kakugawa, Yasuo, additional, Takamaru, Hiroyuki, additional, Sekiguchi, Masau, additional, Matsumoto, Minori, additional, Matsuda, Takahisa, additional, Ito, Ayumu, additional, Tanaka, Takashi, additional, Inamoto, Yoshihiro, additional, Fuji, Shigeo, additional, Kurosawa, Saiko, additional, Kim, Sung-Won, additional, Fukuda, Takahiro, additional, Ohe, Yuichiro, additional, and Saito, Yutaka, additional

Published
2019
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28. The Diagnostic Performance for Colorectal Neoplasms Using Magnified Endoscopy Differs between Experts and Novice Endoscopists: A Post Hoc Analysis.

Author

Inoki, Kazuya, Sakamoto, Taku, Takamaru, Hiroyuki, Sekiguchi, Masau, Yamada, Masayoshi, Matsuda, Takahisa, and Saito, Yutaka

Subjects
*ENDOSCOPY, *TUMORS, *SPECIALISTS, *COMPUTER surveys
Abstract

Introduction: Magnified endoscopy is difficult for novice endoscopists because it requires both knowledge and skill of endoscopic diagnosis. The aim of this study was to examine the diagnostic performance of novice endoscopists on determining the invasive depth of colorectal neoplasms and compare it with that of experts. Methods: The present study was conducted as a post hoc analysis. Thirty expert and 30 novice endoscopists who use magnifying endoscopy (narrow-band imaging [NBI] and pit pattern analysis) were recruited for the online survey. Novice endoscopist was defined as one who has <5 years of experience in magnifying endoscopy. Three outcomes were assessed: (a) diagnostic accuracy of both novice and expert endoscopists in determining the depth of invasion; (b) additional diagnostic accuracy of novice endoscopists in determining the depth of invasion with magnifying NBI or pit pattern compared with nonmagnifying white light imaging (WLI); (c) difference in confidence on diagnosis among each modality between novice and expert endoscopists. Results: The area under the curve (AUC) of expert endoscopists was significantly higher than that of novice endoscopists. The AUC of the pit pattern was significantly higher than that of WLI regardless of lesion characteristics as determined by novice endoscopists. The proportion of answers with high confidence was significantly higher with expert endoscopists than with novice endoscopists. Conclusions: Aside from learning basic diagnosis of colorectal neoplasms, magnifying endoscopy may have substantial clinical benefit for novice endoscopists. [ABSTRACT FROM AUTHOR]

Published
2020
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29. Sa1928 OPTIMAL DOSE-FINDING STUDY OF INTRAVENOUS FLUORESCEIN OF PROBE-BASED CONFOCAL LASER ENDOMICROSCOPY FOR UPPER AND LOWER GASTROINTESTINAL TRACT

Author

Inoki, Kazuya, primary, Abe, Seiichiro, additional, Tanaka, Yusaku, additional, Yamamoto, Koji, additional, Ichijima, Ryoji, additional, Yukihiro, Nakatani, additional, Chen, Hsin-Yu, additional, Takamaru, Hiroyuki, additional, Sekiguchi, Masau, additional, Yamada, Masayoshi, additional, Nonaka, Satoru, additional, Sakamoto, Taku, additional, Suzuki, Haruhisa, additional, Yoshinaga, Shigetaka, additional, Oda, Ichiro, additional, and Saito, Yutaka, additional

Published
2018
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31. Mo1124 CLINICAL AND HISTOLOGICAL FACTORS FOR TECHNICAL DIFFICULTY OF ENDOSCOPIC SUBMUCOSAL DISSECTION ANALYZED IN 414 RECTAL TUMORS

Author

Hihara, Daisuke, primary, Takamaru, Hiroyuki, additional, Saito, Yutaka, additional, Tanaka, Yusaku, additional, Inoki, Kazuya, additional, Sekiguchi, Masau, additional, Yamada, Masayoshi, additional, Abe, Seiichiro, additional, Sakamoto, Taku, additional, Nakajima, Takeshi, additional, and Matsuda, Takahisa, additional

Published
2018
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32. Predictive relevance of lymphovascular invasion in T1 colorectal cancer before endoscopic treatment

Author

Inoki, Kazuya, additional, Sakamoto, Taku, additional, Takamaru, Hiroyuki, additional, Sekiguchi, Masau, additional, Yamada, Masayoshi, additional, Nakajima, Takeshi, additional, Matsuda, Takahisa, additional, Taniguchi, Hirokazu, additional, Sekine, Shigeki, additional, Kanemitsu, Yukihide, additional, Ohe, Yuichiro, additional, and Saito, Yutaka, additional

Published
2017
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33. Feasibility of endoscopic resection using bipolar snare for nonampullary duodenal tumours in familial adenomatous polyposis patients

Author

Inoki, Kazuya, primary, Nakajima, Takeshi, additional, Nonaka, Satoru, additional, Abe, Seiichiro, additional, Suzuki, Haruhisa, additional, Yoshinaga, Shigetaka, additional, Oda, Ichiro, additional, Yamada, Masayoshi, additional, Takatsu, Mizuki, additional, Yoshida, Hiroshi, additional, Taniguchi, Hirokazu, additional, Sekine, Shigeki, additional, Ohe, Yuichiro, additional, and Saito, Yutaka, additional

Published
2017
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35. Mo1123 Capsule Endoscopy After Hematopoietic Stem Cell Transplantation Can Predict Transplantation-Related Mortality

Author

Inoki, Kazuya, primary, Kakugawa, Yasuo, additional, Takamaru, Hiroyuki, additional, Sekiguchi, Masau, additional, Matsumoto, Minori, additional, Matsuda, Takahisa, additional, Tanaka, Takashi, additional, Inamoto, Yoshihiro, additional, Fuji, Shigeo, additional, Kurosawa, Saiko, additional, Kim, Sung-Won, additional, Fukuda, Takahiro, additional, and Saito, Yutaka, additional

Published
2017
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36. Capsule Endoscopy after Hematopoietic Stem Cell Transplantation Can Predict Transplant-Related Mortality.

Author

Inoki, Kazuya, Kakugawa, Yasuo, Takamaru, Hiroyuki, Sekiguchi, Masau, Matsumoto, Minori, Matsuda, Takahisa, Ito, Ayumu, Tanaka, Takashi, Inamoto, Yoshihiro, Fuji, Shigeo, Kurosawa, Saiko, Kim, Sung-Won, Fukuda, Takahiro, Ohe, Yuichiro, and Saito, Yutaka

Subjects
*HEMATOPOIETIC stem cell transplantation, *CAPSULE endoscopy, *CYTOMEGALOVIRUS diseases, *GRAFT versus host disease
Abstract

Background and Objectives: Allogenic hematopoietic stem cell transplantation (allo-SCT) is a curative therapy for hematological malignancies, but transplant-related mortality (TRM) remains a concern. This study aimed to determine the efficacy of capsule endoscopy (CE) by evaluating the correlation between inflammatory findings on CE and TRM. Methods: The data of patients after allo-SCT were retrospectively collected. The association between findings on CE and TRM at 100 days from the CE was evaluated. Results: Of the 94 patients included in the study, 47 showed inflammatory findings on CE. The findings were diagnosed as graft-versus-host disease (GVHD; n = 17), cytomegalovirus (CMV) infection (n = 14), and GVHD with CMV infection (n = 16). Of the 47 patients, 13 (28%) had TRM. Endoscopic diagnoses of these TRM cases were GVHD (n = 4), CMV infection (n = 0), and GVHD with CMV infection (n = 9). In contrast, in the remaining 47 patients who showed no inflammatory findings on CE, 2 patients (4%) had TRM. The proportion of TRM was higher in patients with inflammatory findings than in those without it (28 vs. 4%, p < 0.01). Conclusions: CE may predict TRM in patients who developed gastrointestinal symptoms after allo-SCT. [ABSTRACT FROM AUTHOR]

Published
2020
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37. Depressed‐type submucosal invasive colorectal cancer in a patient with Lynch syndrome diagnosed using short‐interval colonoscopy

Author

Inoki, Kazuya, primary, Nakajima, Takeshi, additional, Sekine, Shigeki, additional, Sugano, Kokichi, additional, Tsukamoto, Shunsuke, additional, Yamada, Masayoshi, additional, Mutoh, Michihiro, additional, Sakamoto, Taku, additional, Matsuda, Takahisa, additional, Sekiguchi, Masau, additional, Ushiama, Mineko, additional, Yoshida, Teruhiko, additional, Sakamoto, Hiromi, additional, Kanemitsu, Yukihide, additional, and Saito, Yutaka, additional

Published
2016
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39. STEC:O111‐HUS complicated by acute encephalopathy in a young girl was successfully treated with a set of hemodiafiltration, steroid pulse, and soluble thrombomodulin under plasma exchange

Author

Yada, Noritaka, primary, Fujioka, Masayuki, additional, Bennett, Charles L., additional, Inoki, Kazuya, additional, Miki, Toyokazu, additional, Watanabe, Akihiko, additional, Yoshida, Toshiko, additional, Hayakawa, Masaki, additional, Matsumoto, Masanori, additional, and Fujimura, Yoshihiro, additional

Published
2015
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40. Newly-developed colonoscope (PCF-PQ260L) is useful for patients with difficult colons.

Author

Inoki K, Yamada M, Kuwabara H, Takamaru H, Sekiguchi M, Sakamoto T, Matsuda T, and Saito Y

Subjects
Aged, Constriction, Pathologic, Female, Humans, Male, Pain Measurement, Retrospective Studies, Tissue Adhesions complications, Colon anatomy & histology, Colonic Diseases diagnosis, Colonoscopes, Equipment Design
Abstract

Background/aims: Preforming total colonoscopy (TCS) is sometimes difficult due to adhesions or long colons. The PCF-PQ260L (PQL) was developed to overcome TCS-related difficulties. The aim of this study was to investigate the performance and usefulness of PQL for difficult colon cases., Materials and Methods: This was a retrospective single center observational cohort study investigating differences in patient characteristics and examination performance between patients examined with PQL, versus standard (SD), scopes. Secondly, we directly compared PQL and SD scopes in patients treated with both types of scope., Results: The PQL was used with 105 patients and SD scopes were used with 1119 patients. Patients in the PQL group were significantly shorter (157cm vs 163cm, p< 0.01) and lighter, compared to the SD group (52 kg vs 58 kg, p< 0.01). There were no significant statistical differences with regard to cecal intubation rate, cecal intubation time, and adenoma detection. Direct comparison of use of PQL and SD scopes on the same patients revealed shorter average cecal intubation time (7 min vs 10 min, p< 0.01), and significantly increased numbers of patients reporting no pain (66 % vs 20 %, p< 0.01) and needing no sedative drugs (48% vs 25 %, p< 0.01) associated with PQL use., Conclusion: The examination performance of the PQL scope was similar to the SD scope. The PQL may be a good option for patients who with difficult colons.

Published
2019
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