1. Seasonal characteristic composition of inorganic elements and polycyclic aromatic hydrocarbons in atmospheric fine particulate matter and bronchoalveolar lavage fluid of COPD patients in Northeast China.
- Author
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Che C, Li J, Dong F, Zhang C, Liu L, Sun X, Ma L, Qi H, and Wang K
- Subjects
- Aged, Air Pollution adverse effects, China, Environmental Monitoring, Female, Fluorenes adverse effects, Fluorenes analysis, Humans, Inorganic Chemicals adverse effects, Male, Middle Aged, Particulate Matter adverse effects, Polycyclic Aromatic Hydrocarbons adverse effects, Pyrenes adverse effects, Pyrenes analysis, Seasons, Air Pollution analysis, Bronchoalveolar Lavage Fluid chemistry, Elements, Inorganic Chemicals analysis, Particulate Matter analysis, Polycyclic Aromatic Hydrocarbons analysis, Pulmonary Disease, Chronic Obstructive etiology, Pulmonary Disease, Chronic Obstructive metabolism
- Abstract
Objective: To explore the composition characteristics of atmospheric fine particulate matter (PM2.5) and bronchoalveolar lavage fluid (BALF), and their impact on the development of chronic obstructive pulmonary disease (COPD)., Methods: The atmospheric PM2.5 samples and BALF samples from COPD patients were collected from June 2, 2017 to October 30, 2018, and allocated into a high-risk of PM2.5 inhalation group and a low-risk PM2.5 inhalation group according to the heating season in Harbin. Inorganic elements were detected by ICP-MS, and polycyclic aromatic hydrocarbons (PAHs) were detected by GC/MS., Results: Twenty-six inorganic elements were found in 54 BALF specimens. There was a high correspondence in inorganic elements between BALF and atmospheric PM2.5. Trace elements Cr, Mn, V, and Co, and toxic trace elements Al, Pb, Cd, As, and Ag were above the upper limit of normal blood. There were significant higher K, Ti, Fe, Co, Cu, Se, Rb, Ag, and Sb in BALF of the high-risk PM2.5 inhalation group (p < 0.05). Sixteen PAHs were detected in 32 BALF samples. The main components of BALF and atmospheric PM2.5 were the high molecular weight PAHs, and the species and concentration of PAHs in BALF and atmospheric PM2.5 are highly consistent., Conclusion: The types and concentrations of inorganic elements and PAHs in BALF of COPD patients are highly consistent with those of atmospheric PM2.5. The sustained high concentrations of Benzo(a)anthracene, Chrysene, Benzo(b)Fluoranthene, Benzo(k)Fluoranthene, Indeno(123-c,d)Pyrene, and Benzo(a)Pyrene in BALF of COPD patients may have long-term adverse effects on COPD patients., (Copyright © 2020 Elsevier Ltd. All rights reserved.)
- Published
- 2020
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