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23 results on '"Inoue, Hiro"'

5. An inhibitor of Krüppel-like factor 5 suppresses peritoneal fibrosis in mice

Author

Muta, Kumiko, primary, Nakazawa, Yuka, additional, Obata, Yoko, additional, Inoue, Hiro, additional, Torigoe, Kenta, additional, Nakazawa, Masayuki, additional, Abe, Katsushige, additional, Furusu, Akira, additional, Miyazaki, Masanobu, additional, Yamamoto, Kazuo, additional, Koji, Takehiko, additional, and Nishino, Tomoya, additional

Published
2021
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22. Hereditary Hemorrhagic Telangiectasia in a Patient Undergoing Hemodialysis with Anticoagulants and Antiplatelets.

Author

Otsuka E, Kitamura M, Sawase K, Nakamura M, Inoue H, Yamaguchi K, Funakoshi S, Takazono T, Mukae H, and Nishino T

Subjects
Humans, Middle Aged, Female, Fatal Outcome, Telangiectasia, Hereditary Hemorrhagic complications, Renal Dialysis adverse effects, Anticoagulants adverse effects, Anticoagulants therapeutic use, Platelet Aggregation Inhibitors adverse effects, Platelet Aggregation Inhibitors therapeutic use
Abstract

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder that causes abnormal blood vessel formation and bleeding. We herein report a 61-year-old woman with aggravated HHT symptoms after hemodialysis initiation. She was diagnosed with HHT based on her recurrent bleeding, abnormal blood vessel formation, and family history. Despite bleeding complications, the patient required anticoagulants and antiplatelet agents to treat cardiovascular complications. Eventually, the patient died of extensive cerebral hemorrhaging. Our experience suggests that special attention should be paid to bleeding complications in high-risk patients.

Published
2024
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23. An inhibitor of Krüppel-like factor 5 suppresses peritoneal fibrosis in mice.

Author

Muta K, Nakazawa Y, Obata Y, Inoue H, Torigoe K, Nakazawa M, Abe K, Furusu A, Miyazaki M, Yamamoto K, Koji T, and Nishino T

Subjects
Animals, Fibrosis, Mice, Mice, Inbred ICR, Peritoneum pathology, Kruppel-Like Transcription Factors antagonists & inhibitors, Kruppel-Like Transcription Factors genetics, Peritoneal Dialysis, Peritoneal Fibrosis chemically induced, Peritoneal Fibrosis prevention & control
Abstract

Back Ground: Krüppel-like transcription factor 5 (KLF5) is a transcription factor regulating cell proliferation, angiogenesis and differentiation. It has been recently reported that Am80, a synthetic retinoic acid receptor α-specific agonist, inhibits the expression of KLF5. In the present study, we have examined the expression of KLF5 in fibrotic peritoneum induced by chlorhexidine gluconate (CG) in mouse and evaluated that Am80, as an inhibitor of KLF5, can reduce peritoneal fibrosis., Methods: Peritoneal fibrosis was induced by intraperitoneal injection of CG into peritoneal cavity of ICR mice. Am80 was administered orally for every day from the start of CG injection. Control mice received only a vehicle (0.5% carboxymethylcellulose solution). After 3 weeks of treatment, peritoneal equilibration test (PET) was performed and peritoneal tissues were examined by immunohistochemistry., Results: The expression of KLF5 was less found in the peritoneal tissue of control mice, while KLF5 was expressed in the thickened submesothelial area of CG-injected mice receiving the vehicle. Am80 treatment reduced KLF5 expression and remarkably attenuated peritoneal thickening, accompanied with the reduction of type III collagen expression. The numbers of transforming growth factor β-positive cells, α-smooth muscle actin-positive cells and infiltrating macrophages were significantly decreased in Am80-treated group. PET revealed the increased peritoneal permeability in CG mice, whereas Am80 administration significantly improved the peritoneal high permeability state., Conclusions: These results indicate the involvement of KLF5 in the progression of experimental peritoneal fibrosis and suggest that Am80 may be potentially useful for the prevention of peritoneal fibrosis through inhibition of KLF5 expression.

Published
2021
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