Search

This article is a commentary to the 2021 article “Generating theory by abduction” by Sætre and Van de Ven about abductive thinking in management theory. Here the authors elaborate on the third stage, idea generation, of Sætre and Van de Ven’s abductive thinking method by expanding upon hunches, serendipitous insights, and disciplined imagination.

Large volumes of liquid water transiently existed on the surface of Mars more than 3 billion years ago. Much of this water is hypothesized to have been sequestered in the subsurface or lost to space. We use rock physics models and Bayesian inversion to identify combinations of lithology, liquid water saturation, porosity, and pore shape consistent with the constrained mid-crust (∼11.5 to 20 km depths) seismic velocities and gravity near the InSight lander. A mid-crust composed of fractured igneous rocks saturated with liquid water best explains the existing data. Our results have implications for understanding Mars' water cycle, determining the fates of past surface water, searching for past or extant life, and assessing in situ resource utilization for future missions.

People with schizophrenia-spectrum and bipolar disorders have difficulty accurately estimating their abilities and skills (impaired introspective accuracy [IA]) and tend to over- or underestimate their performance. This discrepancy between self-reported and objective task performance has been identified as a significant predictor of functional impairment. Yet, the factors driving this discrepancy are currently unclear. To date, the relationships between sleep quality and IA have not been examined. The current study aimed to explore the relationships between sleep quality and IA in participants diagnosed with schizophrenia (SCZ; n = 36), schizoaffective disorder (SCZ-A; n = 55), and bipolar disorder with psychotic features (BP; n = 87). Participants completed tasks of emotion recognition, estimated their performance on the tasks (used to calculate IA), and provided confidence ratings for their accuracy judgments. Participants also self-reported their sleep quality. These results suggest significantly greater discrepancies between self-reported and actual task scores for those with SCZ and SCZ-A compared to participants with BP. For those with SCZ, lower confidence on the tasks and underestimation of abilities were associated with lower sleep quality, while for those with SCZ-A, lower sleep quality was associated with higher confidence and overestimation of performance. Results suggest differential relationships between diagnostic groups. Future research is needed to further explore the factors driving these differing relationships, particularly the contrasting relationships between SCZ and SCZ-A.

Pathogenic constitutional APC variants underlie familial adenomatous polyposis, the most common hereditary gastrointestinal polyposis syndrome. To improve variant classification and resolve the interpretative challenges of variants of uncertain significance (VUSs), APC-specific variant classification criteria were developed by the ClinGen-InSiGHT Hereditary Colorectal Cancer/Polyposis Variant Curation Expert Panel (VCEP) based on the criteria of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG/AMP). A streamlined algorithm using the APC -specific criteria was developed and applied to assess all APC variants in ClinVar and the International Society for Gastrointestinal Hereditary Tumours (InSiGHT) international reference APC Leiden Open Variation Database (LOVD) variant database, which included a total of 10,228 unique APC variants. Among the ClinVar and LOVD variants with an initial classification of (likely) benign or (likely) pathogenic, 94% and 96% remained in their original categories, respectively. In contrast, 41% ClinVar and 61% LOVD VUSs were reclassified into clinically meaningful classes, the vast majority as (likely) benign. The total number of VUSs was reduced by 37%. In 24 out of 37 (65%) promising APC variants that remained VUS despite evidence for pathogenicity, a data-mining-driven work-up allowed their reclassification as (likely) pathogenic. These results demonstrated that the application of APC -specific criteria substantially reduced the number of VUSs in ClinVar and LOVD. The study also demonstrated the feasibility of a systematic approach to variant classification in large datasets, which might serve as a generalizable model for other gene- or disease-specific variant interpretation initiatives. It also allowed for the prioritization of VUSs that will benefit from in-depth evidence collection. This subset of APC variants was approved by the VCEP and made publicly available through ClinVar and LOVD for widespread clinical use. [Display omitted] Application of the gene-specific ACMG/AMP variant classification criteria to >10,000 publicly available germline APC variants through a streamlined algorithm reduced the fraction of VUSs by 37%, demonstrating the feasibility of a systematic classification approach in large datasets. This study might serve as a model for other variant interpretation initiatives. [ABSTRACT FROM AUTHOR]

Background: Schizophrenia, a severe mental disorder, is often complicated by Type 2 Diabetes Mellitus (T2DM), which can further impact patients' psychological health. This study investigated the differences in eating attitudes, depression, and insight between schizophrenic patients with and without comorbid T2DM and explored the correlations among these factors to provide empirical support for clinical interventions. Methods: This case-control study was conducted in Guangdong Province, China. From December 2022 to May 2023, a total of 300 hospitalized patients with schizophrenia (92 with comorbid T2DM and 208 without T2DM) were recruited. Data were collected using the Personal Information Form, Eating Attitudes Test (EAT-26), Hamilton Depression Scale (HAMD), and Insight and Treatment Attitudes Questionnaire (ITAQ). Statistical analyses, including t-tests, ANOVA, and multiple linear regression, were performed to examine differences and predictive factors of eating attitudes among patients. This study was approved by the Ethics Committee of the Affiliated Brain Hospital of Guangzhou Medical University (approval number: 2020028), and written informed consent was obtained from all participants. Results: Patients with schizophrenia and comorbid T2DM exhibited significantly higher risks of eating disorders (EAT-26: 12.54 ± 9.77 vs. 9.07 ± 7.90, P =0.003), more severe depression (HAMD: 14.71 ± 7.36 vs. 11.80 ± 6.04, P =0.001), and poorer insight (ITAQ: 10.46 ± 6.01 vs. 12.16 ± 6.09, P =0.025) compared to those without T2DM. Regression analysis revealed that gender, weekly exercise frequency, depression, and insight were significant predictors of eating attitudes among patients with T2DM. For patients without T2DM, weekly exercise frequency, smoking status, and insight were significant predictors. Conclusion: Schizophrenic patients with comorbid T2DM are facing increasing risks related to eating attitudes, depression, and insight which highlight the need for targeted interventions. Regular psychological assessment and tailored support strategies might improve their mental health and quality of life. Future research should focus on longitudinal studies to clarify causal relationships and develop more effective interventions. [ABSTRACT FROM AUTHOR]

One of Gottlob Frege's most original contributions to logic and philosophy was his logical notation, his 'Begriffsschrift'. While long criticized, dismissed, or simply ignored, the recent secondary literature contains some helpful re-evaluations and partial defenses of it. These rely largely on technical, pragmatic, or cognitive-psychological considerations. In this paper, we reconsider Frege's own reasons for valuing his notation highly. We argue that there is a further semiotic dimension, one that matters epistemologically. This dimension becomes evident once one takes seriously, partly also literally, some striking visual metaphors Frege uses. The result is an interpretation highlighting a side of Frege's position that is not widely known. It involves his views about the indispensable role that language, or sign systems more generally, play for human thought, and especially, for logic and mathematics. More particularly and as we read Frege, a good logical notation allows for expressing conceptual/inferential relations in a 'visually inscribed', thus 'perspicuous' way, and this leads to a special kind of 'insight' in mathematics. Or as we elaborate this point further, it involves a kind of articulation and understanding hardly possible without it. Frege designed his Begriffsschrift with that specific goal in mind. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the demand for digital skills in the workplaces of agricultural graduates to shed light on the specific requirements of digital skills in their jobs. The study employed a qualitative approach and conducted a total of eight semi-structured interviews with graduates from two departments of an agricultural university in Vietnam. The obtained data, processed through thematic coding techniques, successfully revealed insights into digital skills' demand in the jobs of selected participants. Firstly, digital skills were found to be compulsory requirements for jobs for agricultural graduates, although the specific requirements for digital skills varied from job to job. Secondly, the findings revealed that different jobs require different types and levels of digital skills. Thirdly, the performance of digital skills depends on the availability and management of workplaces' digital technology. The study also found that graduates may have the opportunity to obtain jobs that are not directly related to their learning programmes but require digital skills associated with their speciality. The study recommends applying the findings to multiple stakeholders, including government policymakers, higher education policymakers, employers, and higher education students, to bridge the gap between the higher education supply and the market demand for digital skills. [ABSTRACT FROM AUTHOR]

Somatic KIT activating mutations drive most gastrointestinal stromal tumors (GISTs). Disease progression eventually develops with first-line imatinib, commonly due to KIT secondary mutations, and different kinase inhibitors have various levels of treatment efficacy dependent on specific acquired resistance mutations. Ripretinib is a broad-spectrum switch-control KIT/PDGFRA tyrosine kinase inhibitor for patients with advanced GIST who received prior treatment with three or more kinase inhibitors, including imatinib. Exploratory baseline circulating tumor DNA analysis from the second-line INTRIGUE trial determined that patients with advanced GIST previously treated with imatinib harboring primary KIT exon 11 mutations and secondary resistance mutations restricted to KIT exons 17/18 had greater clinical benefit with ripretinib versus sunitinib. We describe the rationale and design of INSIGHT (NCT05734105), an ongoing Phase III open-label study of ripretinib versus sunitinib in patients with advanced GIST previously treated with imatinib exclusively harboring KIT exon 11 + 17/18 mutations detected by circulating tumor DNA. Clinical Trial Registration:NCT05734105 (ClinicalTrials.gov) Plain Language Summary Gastrointestinal stromal tumor (GIST) is rare, but it is the most common mesenchymal tumor (a type of tumor that develops from cells which give rise to soft tissues) of the gastrointestinal tract. The primary treatment for advanced GIST is medication that targets the abnormal mechanisms in cancer cells in order to block tumor growth and spread. Ripretinib is an inhibitor of a protein known as KIT, which is a member of the tyrosine kinase protein family and is involved in the growth of GIST. In a Phase III clinical trial called INTRIGUE, the effects of ripretinib and another receptor tyrosine kinase inhibitor, sunitinib, were compared in patients with advanced GIST previously treated with the drug imatinib. An exploratory analysis from the INTRIGUE trial that characterized baseline circulating tumor DNA in the blood showed a greater clinical benefit with ripretinib versus sunitinib in patients with gene mutations solely occurring in KIT exon 11 + 17 and/or 18 (exon 11 + 17/18). This article describes the rationale and design for a Phase III clinical trial called INSIGHT that will evaluate the benefit of ripretinib compared with sunitinib in patients with advanced GIST whose tumors have mutations in KIT exon 11 and KIT exon 17 and/or 18. Patients will receive ripretinib or sunitinib in 6-week cycles, and investigators will assess survival without cancer progression as the primary outcome, and overall survival, and response of the tumor to these two drugs as secondary outcomes. Tweetable Abstract This article describes the rationale and design for the INSIGHT Phase III trial evaluating patients with second-line advanced GIST who harbor primary KIT exon 11 mutations and secondary resistance mutations restricted to the activation loop (KIT exons 17/18). Executive summary Disease overview & management Gastrointestinal stromal tumor (GIST) is the most common gastrointestinal sarcoma, with approximately 80% of cases driven by activating mutations in KIT. Sunitinib is a multitargeted tyrosine kinase inhibitor (TKI) approved as a second-line therapy for advanced GIST after disease progression on or intolerance to imatinib. Ripretinib is a broad-spectrum switch-control KIT/PDGFRA TKI approved as a fourth-line therapy for advanced GIST. Differential activity of ripretinib & sunitinib against secondary KIT mutations Exploratory baseline circulating tumor DNA (ctDNA) analysis from INTRIGUE determined that patients with KIT exon 11 + 13/14 mutations had improved progression-free survival (PFS) and objective response rate (ORR) with sunitinib versus ripretinib, while those with KIT exon 11 + 17/18 mutations had improved PFS, ORR and overall survival (OS) and a better safety profile with ripretinib versus sunitinib. Design INSIGHT is an international, Phase III, randomized, multicenter, open-label study evaluating the efficacy of ripretinib versus sunitinib in patients with advanced GIST previously treated with imatinib and who have KIT exon 11 mutations and co-occurring mutations exclusively in KIT exons 17/18, as identified by ctDNA. Approximately 54 patients will be randomized 2:1 to receive ripretinib 150 mg once daily (QD; continuous) or sunitinib 50 mg QD (4 weeks on/2 weeks off) in 6-week cycles. Eligible patients must have a histologic diagnosis of advanced GIST and co-occurring KIT exon 11 + 17/18 mutations confirmed by central laboratory ctDNA analysis, as well as radiologic progression on imatinib. The primary outcome measure is PFS based on blinded independent radiologic review (IRR) using modified Response Evaluation Criteria in Solid Tumors version 1.1 (mRECIST v1.1), while key secondary outcome measures are ORR based on blinded IRR using mRECIST v1.1 and OS. Infographic [ABSTRACT FROM AUTHOR]

Background: Schizophrenia, a severe mental disorder, is often complicated by Type 2 Diabetes Mellitus (T2DM), which can further impact patients' psychological health. This study investigated the differences in eating attitudes, depression, and insight between schizophrenic patients with and without comorbid T2DM and explored the correlations among these factors to provide empirical support for clinical interventions. Methods: This case-control study was conducted in Guangdong Province, China. From December 2022 to May 2023, a total of 300 hospitalized patients with schizophrenia (92 with comorbid T2DM and 208 without T2DM) were recruited. Data were collected using the Personal Information Form, Eating Attitudes Test (EAT-26), Hamilton Depression Scale (HAMD), and Insight and Treatment Attitudes Questionnaire (ITAQ). Statistical analyses, including t-tests, ANOVA, and multiple linear regression, were performed to examine differences and predictive factors of eating attitudes among patients. This study was approved by the Ethics Committee of the Affiliated Brain Hospital of Guangzhou Medical University (approval number: 2020028), and written informed consent was obtained from all participants. Results: Patients with schizophrenia and comorbid T2DM exhibited significantly higher risks of eating disorders (EAT-26: 12.54 ± 9.77 vs. 9.07 ± 7.90, P=0.003), more severe depression (HAMD: 14.71 ± 7.36 vs. 11.80 ± 6.04, P=0.001), and poorer insight (ITAQ: 10.46 ± 6.01 vs. 12.16 ± 6.09, P=0.025) compared to those without T2DM. Regression analysis revealed that gender, weekly exercise frequency, depression, and insight were significant predictors of eating attitudes among patients with T2DM. For patients without T2DM, weekly exercise frequency, smoking status, and insight were significant predictors. Conclusion: Schizophrenic patients with comorbid T2DM are facing increasing risks related to eating attitudes, depression, and insight which highlight the need for targeted interventions. Regular psychological assessment and tailored support strategies might improve their mental health and quality of life. Future research should focus on longitudinal studies to clarify causal relationships and develop more effective interventions. [ABSTRACT FROM AUTHOR]

Background: In recent years, both meditation and psychedelics have attracted rapidly increasing scientific interest. While the current state of evidence suggests the promising potential of psychedelics, such as psilocybin, to enhance meditative training, it remains equivocal whether these effects are specifically bound to psilocybin or if other classical psychedelics might show synergistic effects with meditation practice. One particularly promising candidate is N,N -dimethyltryptamine (DMT), an active ingredient of ayahuasca. Aim: This study aims to investigate the effect of the psychedelic substance DMT, combined with the monoamine oxidase inhibitor harmine (DMT-harmine), on meditative states, compared to meditation with a placebo. Method: Forty experienced meditators (18 females and 22 males) participated in a double-blind, placebo-controlled study over a 3-day meditation retreat, receiving either placebo or DMT-harmine. Participants' levels of mindfulness, compassion, insight, and transcendence were assessed before, during, and after the meditation group retreat, using psychometric questionnaires. Results: Compared to meditation with a placebo, meditators who received DMT and harmine self-attributed greater levels of mystical-type experiences, non-dual awareness, and emotional breakthrough during the acute substance effects and, when corrected for baseline differences, greater psychological insight 1 day later. Mindfulness and compassion were not significantly different in the DMT-harmine group compared to placebo. At 1-month follow-up, the meditators who received DMT and harmine rated their experience as significantly more personally meaningful, spiritually significant, and well-being-enhancing than the meditators who received placebo. Conclusion: Investigating the impact of DMT-harmine on meditators in a naturalistic mindfulness group retreat, this placebo-controlled study highlights the specific effects of psychedelics during meditation. Trial registration: ClinicalTrials.gov identifier NCT05780216. [ABSTRACT FROM AUTHOR]

Within the domain of face processing, researchers have been interested in quantifying the relationship between objective (i.e., performance on laboratory tests of recognition and matching) and subjective measures of ability (typically, self-report questionnaires). Put simply, do people show high levels of metacognitive insight into their own abilities with faces? Although several studies have suggested that the association between these two types of measures may only be moderate, there remain several important issues that require consideration before this question can be sensibly investigated. First, specificity is needed regarding both objective and subjective measurements because both tend to span a wide range of potentially separable abilities. Second, experimental tasks appear to focus on different contexts to those tapped in self-report questionnaire items. Third, recent issues with statistical approaches and visualisation can result in numerical artefacts and misinterpretations. Finally, the sizes of population-level insights suggested by recent work provide only limited information regarding individuals within these populations, and so researchers aiming to identify people at the extremes of ability must be careful when drawing conclusions. Taken together, we argue that more attention to these issues is needed when attempting to investigate metacognitive insight within this domain. [ABSTRACT FROM AUTHOR]

The assessment of creativity as an individual difference has historically focused on divergent thinking, which is increasingly viewed as involving the associative processes that are also understood to be a key component of creative potential. Research on associative processes has proliferated in many sub-fields, often using Compound Remote Associates (CRA) tasks with an open response format and relatively small participant samples. In the present work, we introduce a new format that is more amenable to large-scale data collection in survey designs, and present evidence for the reliability and validity of CRA measures in general using multiple large samples. Study 1 uses a large, representative dataset (N = 1,323,480) to demonstrate strong unidimensionality and internal consistency (α =.97; ωt =.87), as well as links to individual differences in temperament, cognitive ability, occupation, and job characteristics. Study 2 uses an undergraduate sample (N = 685) to validate the use of a multiple-choice format relative to the traditional approach. Study 3 uses a crowdsourced sample (N = 357) to demonstrate high test–retest reliability of the items (r =.74). Finally, Study 4 uses a sample that overlaps with Study 1 (N = 1,502,922) to provide item response theory (IRT) parameters for a large set of high-quality CRA items that use a multiple-choice response mode, thus facilitating their use in future research on creativity, insight, and related topics. [ABSTRACT FROM AUTHOR]

Quality of life has emerged as a powerful indicator of therapeutic success. However, little research has been conducted to study potential factors that influence quality of life in persons with schizophrenia, particularly in low-income developing nations. This study aimed to investigate how insight and empathy impacted the quality of life and severity of symptoms in patients. A descriptive cross-sectional research design was conducted on 168 patients with schizophrenia using the PANSS Scale, Schizophrenia Quality of Life Scale R4, the Interpersonal Reactivity Index, and the Birchwood Insight Scale. Our findings show that the mean score for quality of life was (70.9 ± 9.2), whereas the mean scores for empathy and insight were (60.8 ± 15.8) and (5.8 ± 1.9), respectively. Insight and empathy have predicted effects on QoL (adjusted r square = 0.035, sig = 0.009) and (adjusted r square = 0.012, sig = 0.027), respectively. On the other hand, the regression model also showed a substantial inverse relationship between the severity of the illness and both empathy and insight. Conclusion: The majority of the clients had poor quality of life, low insight, and low empathy. Insight and empathy play a role in anticipating the patient's perceptions of quality of life. They might affect how severe their illness is. Our findings highlight the importance of developing empathy and insight, and therapies that do so may aid patients with low quality of life. [ABSTRACT FROM AUTHOR]

Summary: Insight in psychosis is associated with reduced psychotic symptom severity, less coercive treatment and better functioning. Controversially, it has been suggested that insight may lead to depression, higher suicide risk and worse self-perceived quality of life. Future clinical trials are warranted to address this 'insight paradox', particularly the direction of causality. [ABSTRACT FROM AUTHOR]

Bipolar disorder is thought to determine the insights and coping attitudes that affect a patient’s compliance with treatment, which can positively affect the prognosis of the disease. This study aimed to investigate the relationship between insight and coping attitudes in bipolar disorder patients. This descriptive study was carried out with 127 volunteer patients who were diagnosed with bipolar disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and who were in a euthymic state. The Personal Information Form, Beck Cognitive Insight Scale (BCIS) and Scale of Coping Attitudes (COPE) were used as data collection tools. We found positive correlations between the total COPE score, the total BCIS score and the self-reflectivity subscale score of the BCIS. A positive and significant correlation was also determined between the BCIS subscales and total scores and coping attitudes toward adaptation with the COPE subscales (p < 0.05). A positive and significant relationship was found between the insight scores and total coping scores of the patients and their coping attitudes toward adaptation. We found that when patients’ levels of insight increased, their coping attitudes toward adaptation were used more frequently. This study revealed that individuals with high self-reflectivity can cope more effectively with the situations they face. [ABSTRACT FROM AUTHOR]

One pathologist reflects upon her own medical journey and shares how that perspective is carried forward in her practice and her life. [ABSTRACT FROM AUTHOR]

Background: The exploration of metacognition in relation to anxiety has received considerable attention in recent decades. Research indicates that it plays a role in the development and maintenance of anxiety disorders while also providing benefits, including the ability to assess situations, modify behaviors, and make informed decisions. Summary: We propose that having an awareness of a disorder, also known as insight, is related to metacognition in anxiety. This relationship stems from the ability it provides individuals to recognize their mental state through reflection on personal experiences. We discuss the impact of insight and metacognition on decision-making, treatment-seeking behaviors, and coping strategy selection. Key Messages: Understanding the concept of insight in anxiety disorders, as compared to other mental disorders like psychosis, requires exploring its complexities while carefully considering the balance of harms and benefits. While the medicalization of symptoms in psychosis is widely regarded as clearly beneficial, evaluating the role of insight in anxiety disorders demands a more nuanced understanding. Gaining a fuller perspective on patients' beliefs can impact their behaviors and decision-making. Clinicians can achieve this by encouraging active self-reflection to increase awareness, which includes evaluating both severity and impact on daily functioning. This also involves expressing experiences and exploring attributions of anxiety. This practical approach enables clinicians to understand engagement and treatment-seeking behaviors, allowing them to tailor treatment plans and develop effective coping and management strategies. Ultimately, this knowledge promotes a deeper comprehension of insight into anxiety disorders. [ABSTRACT FROM AUTHOR]

Simple Summary: Detour behavior refers to the ability to reach a goal object that is not directly accessible due to an obstacle (opaque or transparent) by circumventing it. It varies among species, suggesting that environmental adaptation may drive insight behavior. Some species of marine and freshwater fish were placed in a corridor with social stimuli at the end, not directly accessible due to an opaque barrier. Two symmetrical apertures positioned midline in the corridor allowed the fish to temporarily abandon the view of the goal and attempt to circumvent the barrier. All fish showed the ability to move around an interposed obstacle. This is the first evidence of detour behavior in marine fishes within the "four-compartment box task", while results in freshwater fishes confirmed previous evidence. The comparable performance of marine and freshwater fishes suggests similar selective ecological pressure even in different aquatic habitats (e.g., sea and freshwater basins). Moreover, different exploratory behaviors emerged between correct and incorrect compartments (particularly in Danio rerio), providing evidence for a possible mental representation or "permanence in existence" of the goal while performing the obstacle circumvention, as opposed to a more parsimonious idea suggesting that the detour ability emerges only from primitive forms of exploratory behavior such as taxis. Evidence of detour ability to reach a salient goal in marine fishes (Chromis viridis, Chrysiptera parasema, Dascyllus aruanus) and freshwater fishes (Xenotoca eiseni, Danio rerio) has been observed using a "four-compartment box task" with an opaque barrier. The first experiment investigated this ability in marine fishes (Chromis viridis, Chrysiptera parasema, Dascyllus aruanus). Fish were placed in a four-compartment box, with social stimuli not accessible due to an opaque barrier. Two symmetrical apertures midline in the corridor allowed the fish to temporarily abandon the goal's view and attempt to circumvent the barrier. Marine fish showed searching behavior in the two compartments near the social stimuli. In the second experiment, the detour abilities of a marine fish (Dascyllus aruanus) and two freshwater fishes (Xenotoca eiseni, Danio rerio) were compared using a modified version of the apparatus, with elongated compartments continuing further from the obstacle barrier and social stimuli. This enabled the evaluation of the dependence on effective distance to achieve the social goal. Both marine and freshwater fish exhibited detour skills. Additionally, Danio rerio's differential spatial explorations inside compartments supported an active interest in searching for conspecifics, suggesting possible social object permanence retention. Overall, these results highlight the ecological salience of detour skills in fishes, irrespective of species-specific adaptations. [ABSTRACT FROM AUTHOR]

The Cognitive Assessment Interview (CAI) is an interview-based scale measuring cognitive impairment and its impact on functioning in subjects with schizophrenia (SCZ). The present study aimed at assessing, in a large sample of SCZ (n = 601), the agreement between patients and their informants on CAI ratings, to explore patients' insight in their cognitive deficits and its relationships with clinical and functional indices. Agreement between patient- and informant-based ratings was assessed by the Gwet's agreement coefficient. Predictors of insight in cognitive deficits were explored by stepwise multiple regression analyses. Patients reported lower severity of cognitive impairment vs. informants. A substantial to almost perfect agreement was observed between patients' and informants' ratings. Lower insight in cognitive deficits was associated to greater severity of neurocognitive impairment and positive symptoms, lower severity of depressive symptoms, and older age. Worse real-life functioning was associated to lower insight in cognitive deficit, worse neurocognitive performance, and worse functional capacity. Our findings indicate that the CAI is a valid co-primary measure with the interview to patients providing a reliable assessment of their cognitive deficits. In the absence of informants with good knowledge of the subject, the interview to the patient may represent a valid alternative. [ABSTRACT FROM AUTHOR]

Double bookkeeping is a term introduced by Eugen Bleuler to describe a fundamental feature of schizophrenia where psychotic reality can exist side by side with shared reality even when these realities seem mutually exclusive. Despite increasing theoretical interest in this phenomenon over the recent years, there are no empirical studies addressing this issue. We have, therefore, conducted a phenomenologically descriptive qualitative study of 25 patients with schizophrenia in which we addressed the following issues: (1) Experience of double reality; (2) Emergence and development of two realities; (3) Truth quality of psychotic or private reality; (4) Insight into illness; (5) Communication of psychotic experiences. The most important result was that most patients felt to be in contact with another dimension of reality. Hallucinatory and delusional experience pertained to this different reality, which patients most frequently kept separated from the shared reality. This other dimension was considered by the patients as being more profound and real. The pre-psychotic and psychotic experiences were difficult to verbalize and typically described as totally different than ordinary experience. Double reality was persistent across remissions. None of the patients considered their condition as an illness analogous to a somatic disorder. Most patients described a vague sense of duality preceding the crystallization of double bookkeeping. This emergence of doubleness was associated with a fundamental alienation from oneself, the world, and others stretching back to childhood or early adolescence. We discuss the results with a special emphasis on the concept of psychosis, clinical interview, treatment, and pathogenetic research. [ABSTRACT FROM AUTHOR]

Serendipity-oriented recommendation systems have been widely applied in major e-commerce and social platforms. Platform managers aim to enhance user satisfaction and increase platform sales by creating serendipitous encounters with information. Previous research has shown that the unexpectedness of encountering product information in serendipity-oriented recommendation systems can effectively stimulate positive emotions in customers, resulting in unplanned purchases, such as impulse buying. However, little research has focused on another critical aspect of encountering product information: perceived value. Our study suggests that encountering product information can positively affect the intention to purchase planned products (focal products) based on their perceived value. To explore this, we conducted three experiments and found that: (1) encountering product information positively influences planned product purchase intention (e.g., reduced decision-making time, improved focal product purchase intention), compared to the absence of encountering product information (precision-oriented recommendation systems); (2) this effect is mediated by customer inspiration; and (3) the characteristics of recommendation system strategies can moderate this effect. Specifically, when the strategy features exhibit a low level of explainability, the impact of encountering product information on customer inspiration and purchase intention is more significant than when a high level of explainability is presented. [ABSTRACT FROM AUTHOR]

Using data from 52 countries in Wave 5 of the World Value Survey conducted during 2004 and 2008, we test two alternative approaches in spirituality measures. The first is based on the more traditional understanding that spirituality is associated with meanings, God, prayers/meditation and formal religions. The second is based on the common spiritual teachings of all the major religions that are summarized by the LIFE (Love, Insight or Wisdom, Fortitude and Engagement) framework proposed by Ho, LS (2014). Psychology and Economics of Happiness: Love, Life and Positive Living. Oxford: Routledge. It was found that this alternative approach, which focuses on the spiritual teachings rather than theology, offers better explanatory power for Total Life Satisfaction (TLS). An interesting finding is that under this specification the coefficient on meaning turned negative, suggesting that those whose lives are weak in Love, Insight, Fortitude and Engagement have yet to find meaning and are less happy. Through a series of stepwise regressions, we conclude that more spiritual people are indeed happier (H1); that religious people indeed tend to be happier mainly because religious people tend to be more spiritual (H2); that the essence of spirituality and meaning lies in Love, Insight, Fortitude and Engagement (H3). These virtues are all grounded on transcending the narrow self and on a "reverence for Life" as propounded by Schweitzer. Finally, religious attendance does promote happiness. The effect is small but stable and statistically significant. It may have to do with the social network this offers (H4). [ABSTRACT FROM AUTHOR]

Abstract Background Recovery from severe mental illness, including psychosis has been described as a personal and unique process, but it rarely is a journey undertaken without profound influences of significant others (family, mental health professionals). Diverging perspectives between persons with severe mental illness, family and professionals are frequent during the recovery process, notably in psychotic disorders. We aimed to explore processes of collaboration during recovery, to inform recovery supporting practices. Methods Current qualitative study had a participatory design and was set within long-term mental healthcare for severe mental illness. We conducted semi-structured interviews and focus groups with persons with severe mental illness (most had a history of psychosis), family and professionals on their mutual contact during recovery. Using reflexive thematic analysis, we developed themes representing processes of collaboration during recovery. Results We described roles persons with severe mental illness, family and professionals attribute to each other in mutually influential terms of unconditional and meaningful contact (which takes time to establish) and problem-oriented aspects. Secondly, experienced differences over problem definition, “needing help” and consequently over the role parties attribute to one another, may result in negative interactions, in the area of having expectations; (not) informing; (not) having agency to change; experiencing (dis)agreement or struggle. Conclusions unconditional, meaningful contact and knowing each other’s perspective are important to fruitful interaction in a triad when perspectives on mental health problems diverge. Relationally centered and process oriented care with continuity of family and professionals involved are needed to advance recovery in severe mental illness, especially psychosis.

BACKGROUND: Studies that examined sex differences in first-episode patients consistently show that males compared to females have poor premorbid adjustment, earlier age of onset, worse clinical characteristics, and poorer outcomes. However, little is known about potential mediators that could explain these sex differences. METHODS: Our sample consisted of 137 individuals with first episode schizophrenia (males, n = 105; 77%) with a mean age of 22.1(s.d. = 4.1) years and mean education of 12.5(s.d. = 1.7) years. At entry, patients were within 2 years of their first psychotic episode onset. Baseline assessments were conducted for premorbid adjustment, symptoms, cognitive functioning, insight, and at 6-months for role and social functioning. RESULTS: Males as compared to females had poorer premorbid adjustment across several key developmental periods (p < 0.01), an earlier age of onset [M = 20.3(3.3) v. 22.8(5.6), p = 0.002], more negative symptoms (p = 0.044), poorer insight (p = 0.031), and poorer baseline and 6-month role (p = 0.002) and social functioning (p = 0.034). Several of these variables in which males showed impairment were significant predictors of 6-month role and social functioning. Premorbid adjustment and insight mediated the relationship between sex and role and social functioning at 6-months, but not negative symptoms. DISCUSSION: Males compared to females were at lower levels across several key premorbid and clinical domains which are strongly associated with functional outcome supporting the hypothesis that males might have a more disabling form of schizophrenia. The relationship between sex with role and social functioning was mediated through premorbid adjustment and insight suggesting pathways for understanding why females might have a less disabling form of schizophrenia.

Background: Impaired self-awareness (ISA) is common in individuals with an acquired brain injury (ABI) and can lead to reduced awareness of one's difficulties. Previous reviews have found that ISA impacts on functional outcomes in rehabilitation. However, to date there has not been a systematic literature review which examines how ISA impacts on the process of rehabilitation in ABI populations. Method: A literature search was conducted using several databases in May 2024, including Academic Search Premier, CINAHL, MEDLINE, APA PsycARTICLES and APA PsycINFO. Seventeen articles were selected for the review and were analyzed using Narrative Synthesis. Results: Four themes arose from the findings, including goal setting, treatment adherence, engagement and willingness to change and time spent in hospital. ISA was found to impact on the value adult ABI participants placed in rehabilitation, which decreased treatment compliance, motivation, and engagement. ISA also impacted on goal setting and behavior and resulted in a longer length of time spent in hospital. Conclusion: This review emphasizes the impact of ISA on various aspects/processes of rehabilitation in ABI and provides considerations of how clinicians might adapt interventions to manage these difficulties. [ABSTRACT FROM AUTHOR]

Genetic investigations do not form part of the routine assessment of patients with psychosis in secure settings. The case of a man admitted to a low secure unit after initial civil detention is presented. He was arrested after violence at home and there followed persistent violence in adult general wards. Many risk factors for violence were present and would usually be considered sufficient explanations for the totality of his presentation and risk. The novel aspect was the results of genetic testing. This revealed associations with his physical appearance, development and neurodevelopment, early onset violence and aggression, psychosis, and possibly the excellent response to clozapine. Array Comparative Genomic Hybridisation (aCGH) revealed a 15q13.2-13.3 microduplication, with the genetic report suggesting that many of the clinical aspects were, at least in part, attributable to this finding. This provided a complimentary narrative explanation for a presentation which had been difficult to treat and understand by both the patient and treating team. This is the only case report to describe this specific diagnosis from the patient's perspective and the helpful impact of the genetic diagnosis, particularly for the patient himself. A brief overview of genetic findings relevant to forensic practice is described. [ABSTRACT FROM AUTHOR]

Although mentorship is vital for individual success, potential mentors often view it as a costly burden. To understand what motivates mentors to overcome this barrier and more fully engage with their mentees, we introduce a new construct, "learning direction," which captures the beliefs people have about which individuals within a hierarchy—upward, lateral, or downward—are valuable sources of knowledge. Although most mentors believe knowledge resides higher up in hierarchies, the current research demonstrates mentors are more engaged and effective when they value insights from below. Our first three studies found that downward learning predicted mentor engagement (Study 1) because downward learning-directed mentors viewed mentoring as a worthwhile opportunity for their own learning (Studies 2A and 2B). A field study examined downstream consequences on mentees' learning outcomes, finding that downward learning-directed mentors trained more hireable mentees (Study 3). A final experiment established causality while also demonstrating that learning direction is open to intervention: reflecting on a downward learning experience increased mentor engagement, which enhanced the mentorship experience for their mentees (Study 4). We extend theories on learning orientation to learning direction and demonstrate that beliefs about the hierarchical sources of learning are critical to successful mentoring. [ABSTRACT FROM AUTHOR]

Serendipity-oriented recommendation systems have been widely applied in major e-commerce and social platforms. Platform managers aim to enhance user satisfaction and increase platform sales by creating serendipitous encounters with information. Previous research has shown that the unexpectedness of encountering product information in serendipity-oriented recommendation systems can effectively stimulate positive emotions in customers, resulting in unplanned purchases, such as impulse buying. However, little research has focused on another critical aspect of encountering product information: perceived value. Our study suggests that encountering product information can positively affect the intention to purchase planned products (focal products) based on their perceived value. To explore this, we conducted three experiments and found that: (1) encountering product information positively influences planned product purchase intention (e.g., reduced decision-making time, improved focal product purchase intention), compared to the absence of encountering product information (precision-oriented recommendation systems); (2) this effect is mediated by customer inspiration; and (3) the characteristics of recommendation system strategies can moderate this effect. Specifically, when the strategy features exhibit a low level of explainability, the impact of encountering product information on customer inspiration and purchase intention is more significant than when a high level of explainability is presented.

Background: Obsessive compulsive disorder (OCD) is a clinically heterogeneous psychiatric disorder in terms of symptom content and insight. Aim: To study the various factors associated with insight in OCD. Materials and Methods: A cross-sectional hospital-based study was conducted among 40 patients with OCD who were evaluated on Yale-Brown Obsessive-Compulsive Scale, Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale, Brown Assessment of Beliefs Scale, Meta-Cognitions Questionnaire, WHOQOL-BREF, and Sheehan Disability Scale. Statistical analysis was done using SPSS version 22. Results: Metacognition, severity of OCD, and associated disability were the significant predictors for insight in patients with OCD. Conclusion: Factors associated with insight in OCD can enhance our understanding in the management of OCD.

The InSight (Interior Exploration using Seismic Investigations, Geodesy, and Heat Transport) mission has recorded continuous ambient noise signals with many spectral peaks since its landing in 2018. The majority of these peaks are modes produced by instrumental vibrations and are associated with environmental factors, such as temperature and wind energy fluctuations. Understanding how these modes react under various conditions is crucial because it aids in identifying their origins. In this study, we analyzed the three-component spectra of InSight recordings from sols 184–738 and obtained the horizontal-to-vertical spectral ratio (HVSR, also known as H/V) curves for different time intervals. The primary modes, such as those at 3.3 and 4.1 Hz, exhibited different behaviors, suggesting diverse origins. Some modes were sensitive to low temperature and some were sensitive to high temperature. Additionally, we investigated the influence of wind and temperature on the H/V curve. The peak frequency was mainly affected by temperature, whereas the H/V value was not associated with the temperature or wind only. Characterizing these modes and elucidating their origins are significant for processing signals from InSight and can provide valuable guidance for designing future planetary seismometers.

The goal of rehabilitating individuals with chronic pain is to assist them in reclaiming control over their pain management and channeling their focus towards well-being and improving function. By providing rational information that helps patients understand their pain, their distress can be alleviated, resulting in positive changes in both their emotional and behavioral responses. Practitioners can assist patients in comprehending their pain and developing an effective management plan by employing a case formulation model. Within the cognitive behavioral model of chronic pain, event-meaning coupling can be emphasized in case formulation, allowing for a greater focus on the patient’s internal cognitive processes, helping them gaining insight into their pain. This model also considers potential biopsychosocial factors that could afford the patient’s ability to make new meaning from events. By assessing and promoting positive event-meaning couplings, patients can be empowered to interact more effectively with their biopsychosocial arena, which in turn can foster a virtuous cycle for self-expansion for successful rehabilitation.

Abstract Background and objectives Obsessive–compulsive disorder (OCD) is a chronic psychiatric disorder defined by the existence of obsessions and/or compulsive behaviors or mental acts persistently and affects around 1–3% of the population in the world. Multiple studies demonstrated the link of the insight level to how severe was OCD and existence of resistance to both medications and psychotherapy in individuals with OCD. Studying the characteristics associated with poor insight is very important for management of treatment-resistant OCD and development of new therapeutic approaches. The purpose of this work was to assess the level of the insight in Egyptian patients with OCD, identify clinical correlates that could anticipate the degree of insight, and assess the validity and reliability of brown assessment of belief scale after being translated to Arabic version. Methods A comparative cross-sectional study of 96 individuals (male and female aged from 18 to 60) diagnosed with OCD based on the Arabic version of the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). The study excluded any individuals with any coexisting neuro-psychiatric conditions and a history of major medical disease. Severity of OCD was assessed through the Arabic version of the Yale–Brown Obsessive–Compulsive Scale (YBOCS). Subsequently, participants performed the Brown Assessment of Beliefs Scale (BABS) after being translated into Arabic and assessed for reliability, validity and applicability of the translated form. Results Patients with OCD presented with poor insight were associated with more untreated time interval, longer disease duration and more severity that was dramatically differed (p ≤ 0.05, ≤ 0.001, ≤ 0.05 respectively). Also, there was a substantial notable correlation among BABS and YBOCS obsession, compulsion, and total score. Conclusions The existence of good insight in patients diagnosed with OCD was associated with lower severity and less duration of illness compared to patients with poor insight. Also, the more time waited before the intervention the worst the patient scores on the insight scale.

Background: People with dementia commonly have impaired social functioning and may not recognize this. This lack of awareness may result in worse outcomes for the person and their family carers. Objective: We aimed to characterize awareness of social functioning in dementia and describe its association with dementia severity. Methods: Multi-center cross-sectional study of people aged >65 years with dementia and family informants recruited from Germany, Japan and the United Kingdom. We used the Social Functioning in Dementia (SF-DEM) scale, assessing "spending time with other people" (domain 1), "communicating with other people" (domain 2), and "sensitivity to other people" (domain 3), and calculated lack of awareness into social functioning as the discrepancy between patient and informant ratings. Results: 108 participants with dementia (50.9% women), mean age = 78.9 years, and mean MMSE score = 22.7. Patient and informant domain 1 ratings did not differ, but patient-rating was higher than carers for domain 2 (11.2 versus 10.1; p = 0.003) and domain 3 (9.7 versus 8.1; p < 0.001). Sixty people with dementia overestimated their overall social functioning, 30 underestimated, and 18 gave ratings congruent with their informant. Performance on the MMSE and its sub-domains was not associated with SF-DEM discrepancy score. Conclusions: We found that awareness of social functioning in dementia was a multidimensional concept, which varies according to subdomains of social functioning. Clinicians should help family members understand and adapt by explaining their relative with dementia's lack of awareness about aspects of their social functioning. [ABSTRACT FROM AUTHOR]

Solving problems with insight culminates in an "Aha! moment": a feeling of confidence and pleasure. In daily life, insights are often followed by important decisions, such as deciding what to do with a new idea. Here, we investigated whether having an Aha! moment affects subsequent decision-making. Because Aha! moments tend to elicit positive affect, which is generally associated with an increased risk-taking tendency, we hypothesized that people would favor a monetary payout with more upside despite greater uncertainty after solving a problem with insight. Participants were asked to solve verbal puzzles and report whether they solved them with insight or without insight. After each puzzle, they chose between two bonuses: a fixed payout or a risk payout with 50% chance of receiving a high or a low payout. Participants were more likely to choose the risk payout after they solved with insight compared to without, suggesting a temporarily higher risk preference. The study provided pre-liminary evidence of a carryover effect - the impact of an Aha! moment on the subsequent risk choice - that can have implications in everyday decision-making. [ABSTRACT FROM AUTHOR]

Insight has been studied as an element of problem solving in the field of cognitive psychology and may play an important role in clinical reasoning. We propose a new strategy based on theories that promote insight that may help generate further diagnostic hypotheses by reviewing the interpretation of a case and an individual's list of differential diagnoses from multiple perspectives: formation (F), re-encoding (R), analogy (A), modification (M), elaboration (E), and deliberation (D) (FRAMED). The FRAMED strategy may help clinicians overcome misinterpretations and cognitive bias by systematically reflecting on previous clinical reasoning processes from multiple perspectives. [ABSTRACT FROM AUTHOR]

aims to clarify the truth of the question in its essence and importance, clarify the location of the question and the limits of the mind, show the status of the question in the circle of interaction and work, reveal the breadth of the question and its openness to realistic fields. And future prospects. The study used the descriptive, analytical, deductive approach. The scientific architecture of this study consists of an introduction and four chapters: the first chapter: the question (essence and importance). The second chapter: the question (reason and limits) The third chapter: the question (interaction and function). The fouth chapter: Question (scope and outlook). Its most prominent results were: that questioning is an original and fundamental driver of science and knowledge, indispensable in the making of life and biology, and that the mind has limits defined by law and nature, and has no entry into the absolute unseen, neither by obligation nor curiosity, and that questioning includes what is imposed and what is rejected, and that the purpose of science is work, not science for itself, and that time is real by investing it in science and civilizational advancement based on religion, values, science, and work, and that the most important questions of the era are knowing the present and anticipating the future. [ABSTRACT FROM AUTHOR]

Metaphor generation is both a creative act and a means of learning. When learning a new concept, people often create a metaphor to connect the new concept to existing knowledge. Does the manner in which people generate a metaphor, via sudden insight (Aha! moment) or deliberate analysis, influence the quality of generation and subsequent learning outcomes? According to some research, deliberate processing enhances knowledge retention; hence, generation via analysis likely leads to better concept learning. However, other research has shown that solutions generated via insight are better remembered. In the current study, participants were presented with science concepts and descriptions, then generated metaphors for the concepts. They also indicated how they generated each metaphor and rated their metaphor for novelty and aptness. We assessed participants' learning outcomes with a memory test and evaluated the creative quality of the metaphors based on self‐ and crowd‐sourced ratings. Consistent with the deliberate processing benefit, participants became more familiar with the target science concept if they previously generated a metaphor for the concept via analysis compared to via insight. We also found that metaphors generated via analysis did not differ from metaphors generated via insight in quality (aptness or novelty) nor in how well they were remembered. However, participants' self‐evaluations of metaphors generated via insight showed more agreement with independent raters, suggesting the role of insight in modulating the creative ideation process. These preliminary findings have implications for understanding the nature of insight during idea generation and its impact on learning. [ABSTRACT FROM AUTHOR]

The present study aims to elucidate whether insight problem solving could be facilitated by the cognitive component of humour. The authors take interest in whether the logical mechanisms of humour can affect how fast insight problems are solved. To that end, the authors conducted two experiments where participants solved insight problems after watching visual humorous stimuli such as videos and slideshows. The first experiment demonstrated the overall impact of facilitation by humour on insight problem solving; however, it did not show any difference in how particular logical mechanisms of humour affect the solution time of insight problems. The second experiment showed that the cognitive component of humour could selectively affect insight problems whose difficulty stems from different sources. These results suggest that the cognitive component of humour, when operationalised as logical mechanisms and schema switching, contributes to solving insight problems. [ABSTRACT FROM AUTHOR]

The motto of the conspiracist, "Do your own research," may seem ludicrous to scientists. Indeed, it is often dismissed as a mere rhetorical device that conspiracists use to give themselves the semblance of science. In this perspective paper, we explore the information-seeking activities ("research") that conspiracists do engage in. Drawing on the experimental psychology of aha experiences, we explain how these activities, as well as the epistemic experiences that precede (curiosity) or follow (insight or "aha" experiences) them, may play a crucial role in the appeal and development of conspiracy beliefs. Aha moments have properties that can be exploited by conspiracy theories, such as the potential for false but seemingly grounded conclusions. Finally, we hypothesize that the need for autonomous epistemic agency and discovery is universal but increases as people experience more uncertainty and/or feel epistemically excluded in society, hence linking it to existing literature on explaining conspiracy theories. Recent events have made it painfully clear that conspiracy beliefs can tear deep rifts in society and that we still have not found an adequate, de-escalating response to this. To understand the appeal of conspiracy theories and find new, humanizing ways to talk about them, we propose in this perspective paper to start from the universal human need to autonomously make discoveries through personal knowledge-generating actions. Indeed, psychological research shows that the aha experiences that accompany subjective discoveries create confidence in and perceived ownership of ideas that may be exploited by conspiracy theories. We hypothesize that people experiencing more uncertainty and/or epistemic exclusion in society will especially feel the need to re-establish autonomous epistemic agency and discovery. While this explanation starts from shared human experiences and practices, it also illustrates the potential of those processes to lead to a narrowed world and ossified cognition. [ABSTRACT FROM AUTHOR]

In this paper, I aim to clarify the role of 'wonder' in education. Most of us who work in education want to provide valuable experiences for our students, and we want them to be driven by intrinsic values such as truth and recognition of the dignity of human existence. However, whilst I echo many of the sentiments espoused by advocates of the utility and ethical significance of wonder, I contend that some recent developments—and in particular, Schinkel's argument that 'deep' ('contemplative' or 'cosmic') wonder has a 'fundamental' role in education—are misconceived. This is, I argue, because any concept deployable within educational spaces (whether formal or informal) must pay due regard to the conceptual constraints of the concept of 'education'; that is, attention must be paid to the role of 'learning'. Schinkel's proposals are, I suggest, vulnerable to a critique of sentimentalism and excessive romanticism. As such, they offer little in terms of practical import for educators. As I will propose, if we are to take 'wonder' seriously in educational contexts, we must pay attention to the purpose of wonder as an epistemic emotion; namely, aiming for knowledge and understanding, and getting there requires sensitivity to practical know-how and conceptual competence. [ABSTRACT FROM AUTHOR]

Ideal partner preferences for traits in a partner are said to be stable cognitive constructs. However, longitudinal studies investigating the same participants' ideals repeatedly have so far been limited to relatively short retest intervals of a maximum of 3 years. Here, we investigate the stability and change of ideals across 13 years and participants' insight into how ideals have changed. A total of 204 participants (M = 46.2 years, SD = 7.4, 104 women) reported their ideals at two time points. We found a mean rank-order stability of r =.42 and an overall profile stability of r =.73 (distinctive r =.53). Some ideals changed over time, for example, increased for status-resources in relation to age and parenthood. We found some but varying insight into how ideals had changed (mean r =.20). Results support the idea of ideals being stable cognitive constructs but suggest some variability related to the demands of different life stages. [ABSTRACT FROM AUTHOR]

This research aimed to examine the compound effects of polyacrylamide (PAM) and cadmium (Cd) on plant growth subsequent to the mixing of municipal sludge with soil and to explore the potential ecological risks associated with the use of sludge. A pot experiment was performed wherein four gradients (0, 5, 15, and 20 g/[kg dry sludge]) were established corresponding to different PAM concentrations to assess the effects on the physiological and biochemical parameters of Brassica campestris L. ssp. chinensis Makino and Brassica campestris L. and the effects on Cd and PAM concentrations in soil. The findings indicated that the biomass of both plants increased when the total PAM concentration ranged from 5 g to 15 g/(kg dry sludge). Concurrently, polyacrylamide (PAM) downplayed the uptake of Cd by the plants, reduced phytotoxicity, and increased the activities of antioxidant enzymes such as superoxide dismutase (SOD) and peroxidase (POD) in the roots. However, the biomass of Brassica campestris L. ssp. chinensis Makino and Brassica campestris L. decreased significantly when the total PAM concentration was exceeded 15 g/(kg dry sludge), and the toxic effect of Cd on pants was enhanced to some extent. Especially when the PAM concentration was 20 g/(kg dry sludge), apparent cell damage was observed in root cells. It was further noted that Brassica campestris L. portrayed a higher tolerance towards higher proportions of sludge compared with Brassica campestris L. ssp. chinensis Makino. Sludge holds a wider scale of applicability in landscaping than in agriculture. A fusion of polyacrylamide (PAM) and antioxidant enzymes could potentially counteract the effects of Cd within a specific concentration range, serving as a defense mechanism against stress. The data obtained from this study are crucial for unraveling anti‐stress responses and detoxification mechanisms employed by different plant species under the influence of factors such as PAM, Cd, and others, thus providing novel insights into research related to land use involving sludges. [ABSTRACT FROM AUTHOR]

Physical impulses can be employed as a communication tool with the outside world due to the structure and organization of the human brain. Cognition is sparked by sensory perception. When children are consistently exposed to sensory experiences, they develop an understanding of their external reality, shaping and designing their internal view. The central nervous system converts these physical impulses into signals and stores the information in the modules of the brain as signals. According to embodiment theory, which is based on the idea that the body and the mind correlate, the materialized body impacts how thoughts are processed. The interdependency between sight and insight is the subject of this paper, along with the relationship between this duality and the mythic system. The novel Woman at Point Zero by Nawal El Saadawi uses eye symbolisms excessively, signifying the Egyptian mythology of the Eye of Horus. This paper is structured into three areas. The first part deals with the Egyptian mythology of the Eye of Horus and further allusions to the third eye. The second part investigates eye symbolism in the novel, and the third part focuses on the sight-insight interplay. In brief, this paper is about how the author uses sight-insight connectedness to describe the famous mythical Eye of Horus pattern and how the outward and inward vision develops throughout the work. [ABSTRACT FROM AUTHOR]

Objectives: The study was conducted to determine the relationship between insight and quality of life levels of individuals diagnosed with schizophrenia. Methods: The data of this descriptive and correlational study were collected at a community mental health center (CMHC) in a province located in the Black Sea Region of Türkiye between February 2021 and July 2021. The population of the study consisted of 224 patients who were registered to the CMHC and diagnosed with schizophrenia according to DSM-V diagnostic criteria between the specified dates. According to the sample calculation for a known population, the minimum number of people to be included in the sample was calculated as 141 (confidence interval: 95%, margin of error: 5%). However, considering the possibility of withdrawals and/or losses during the study, we decided to include more people. Thus, the study was completed with 148 patients who volunteered to participate in the study and met the inclusion criteria. The three tools used to collect the data were the "Sociodemographic Data Form" prepared by the researcher, "Birchwood Insight Scale (BIS)," and "Quality of Life Scale for Patients with Schizophrenia (QLSPS)." Data were analyzed using the Statistical Program for the Social Sciences 22. In the analysis of the data, the Shapiro-Wilk test was used to determine whether the data were normally distributed. In the analysis of the data, numbers, arithmetic mean, percentile distributions, and standard deviation were used. While Pearson's correlation analysis was used to determine the relationship between the scales, the Cronbach's alpha coefficient was used to calculate the reliability coefficients of the scales. Results: According to the study findings, the mean scores the patients obtained from the overall BIS and the QLSPS were 4.16±1.63 and 76.93±14.84, respectively. According to the analysis of the relationship between the sub-dimensions of the BIS and the sub-dimensions of the QLSPS, there was a negative and weak correlation between the mean scores obtained from the overall BIS and its Being Aware of the Symptoms and Being Aware of the Disease sub-dimensions and the mean scores obtained from the overall QLSPS and its interpersonal relationships sub-dimension. There was a negative, significant, and weak correlation between the mean score for the overall BIS and the mean scores for the occupational role, daily use of belongings, and activities sub-dimensions of the QLSPS (p<0.05). Conclusion: The patients had a low level of insight and a high level of quality of life. A relationship was determined between the mean scores the participants obtained from the BIS and the mean scores that they obtained from the QLSPS. [ABSTRACT FROM AUTHOR]

Neurological soft signs (NSS) are subtle motor control impairments that include involuntary movements and abnormalities of motor coordination, sensory integration and lateralization. They engage different brain networks, including the prefrontal networks that support the higher cognitive functions that are dysfunctional in obsessive-compulsive disorder (OCD). This study investigated the relationships between the presence of NSS and patients' severity of OCD symptoms, insight, and treatment resistance in a sample of 63 patients. Treatment-resistance was assessed considering all the treatments the patients received during the course of their disease. The four dimensions of OCD defined in the dimensional obsessive-compulsive scale were considered. Links between the patients' cognitive abilities and NSS were assessed using tests targeting specifically the core components of executive functions. As expected, OCD patients displayed more NSS than individually matched control participants. In OCD patients, high NSS scores were associated with poor insight and lower cognitive abilities. Multiple regression analysis identified worse visuospatial working memory, attentional control, and verbal fluency as predictive factors of high NSS scores among cognitive functions. Unexpectedly, the patients displaying symptoms in the contamination/washing dimension displayed less NSS than the other patients. In contrast, neither the severity of OCD symptoms nor long-range treatment resistance was significantly related to patients' NSS scores. Altogether, our findings suggest that high NSS scores may be a trait marker of a subset of OCD patients with low insight and particularly altered cognitive abilities who would not express the contamination/washing dimension of the pathology. [ABSTRACT FROM AUTHOR]

Background: Obsessive compulsive disorder (OCD) is a clinically heterogeneous psychiatric disorder in terms of symptom content and insight. Aim: To study the various factors associated with insight in OCD. Materials and Methods: A cross-sectional hospital-based study was conducted among 40 patients with OCD who were evaluated on Yale-Brown Obsessive-Compulsive Scale, Hamilton Anxiety Rating Scale, Hamilton Depression Rating Scale, Brown Assessment of Beliefs Scale, Meta-Cognitions Questionnaire, WHOQOL-BREF, and Sheehan Disability Scale. Statistical analysis was done using SPSS version 22. Results: Metacognition, severity of OCD, and associated disability were the significant predictors for insight in patients with OCD. Conclusion: Factors associated with insight in OCD can enhance our understanding in the management of OCD. [ABSTRACT FROM AUTHOR]

As historians, our work becomes both easier and more difficult when we select topics in which we are personally involved, or causes about which we care passionately. A primer for activist scholars, this essay offers eight insights for those who seek to contemplate, and question, scholarly convention rather than uncritically uphold it, drawing on the author's experience as a health activist and her writing on the history of fitness. This essay is part of a PHR forum on the theme of "Personal Reflections on Feminist Historical Methods," with additional essays by Judy Tzu-Chun Wu, Y. Yvon Wang, and Natalie Marine-Street. The forum is part of a larger PHR special issue, Feminist Histories. [ABSTRACT FROM AUTHOR]

Introduction: Insight in psychosis has been conceptualized as a continuous, dynamic, and multidimensional phenomenon. This study aims to determine the impact of delusions and hallucinations in different dimensions of clinical insight in schizophrenia spectrum disorders. Methods: Cross-sectional multicenter study including 516 patients (336 men) diagnosed with schizophrenia spectrum disorders. Based on dichotomized scores of Positive and Negative Syndrome Scale (PANSS) items P1 (delusions) and P3 (hallucinations), patients were assigned to four groups according to current clear presence of delusions (scores 4 or above 4 in PANSS item P1) and/or hallucinations (scores 4 or above 4 in PANNS item P3). Insight was assessed using the three main dimensions of the Scale of Unawareness of Mental Disorder (SUMD). Results: Around 40% of patients showed unawareness of illness; 30% unawareness of the need for treatment; and 45% unawareness of the social consequences of the disorder. Patients with current clear presence of delusions had higher overall lack of awareness, regardless of current clear presence of hallucinations. Similarly, the clear presence of delusions showed a greater predictive value on insight than the presence of hallucinations, although the implication of both in the prediction was modest. Conclusions: Our results confirm that lack of insight is highly prevalent in schizophrenia spectrum disorders, particularly when patients experience delusions. This study adds insight-related data to the growing symptom-based research, where specific types of psychotic experiences such as hallucinations and delusions could form different psychopathological patterns, linking the phenomenology of delusions to a lack of clinical insight. [ABSTRACT FROM AUTHOR]

The article aims to analyze the possibilities of using metaphoric associative cards for working with businesses and organizations. Metaphoric associative cards could be used as an additional tool in counseling to provide the ability to work simultaneously within the emotional, mental, and physical dimensions of the client, creating a secure space for reflections during the team sessions and enhancing creativity during brainstorming. Enterprise organizations and small and medium businesses overcoming market challenges, and financial changes should adapt to any scenarios and transform rapidly by representing innovative solutions (new products, services, processes, opening new markets, going through M&A, etc.). Such transformations bring anxiety for an organization and all employees as the level of uncertainty is high and bringing clear communications to the company culture, developing space for reflection is critical (Giernalczyk, Lohmer, 2012). To discover potential scenarios of strategic development, working with a portrait of the customers for improvement for customer journeys, discovering blockers or potential root causes of new project initiations working with metaphors through the session with MAC could be helpful. Practical techniques that could be used during the work on requests of organizations described. [ABSTRACT FROM AUTHOR]

Copyright of Gharee for Economics & Administration Sciences is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)