1. Improvement in insulin sensitivity and serum leptin concentration after the switch from a ritonavir-boosted PI to raltegravir or dolutegravir in non-diabetic HIV-infected patients
- Author
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Marco Borderi, Maria Carla Re, Simona Coladonato, Leonardo Calza, Isabella Bon, Vincenzo Colangeli, Pierluigi Viale, Beatrice Tazza, Calza, Leonardo, Colangeli, Vincenzo, Borderi, Marco, Coladonato, Simona, Tazza, Beatrice, Bon, Isabella, Re, Maria Carla, and Viale, Pierluigi
- Subjects
0301 basic medicine ,Leptin ,Male ,medicine.medical_treatment ,HIV Infections ,Insilun, serum leptin, switch therapy, HIV ,Gastroenterology ,Piperazines ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,immune system diseases ,Antiretroviral Therapy, Highly Active ,Pharmacology (medical) ,030212 general & internal medicine ,Prospective Studies ,Coinfection ,Drug Substitution ,virus diseases ,Middle Aged ,Viral Load ,Infectious Diseases ,Treatment Outcome ,Dolutegravir ,Female ,Heterocyclic Compounds, 3-Ring ,medicine.drug ,Microbiology (medical) ,Adult ,medicine.medical_specialty ,Pyridones ,030106 microbiology ,Emtricitabine ,03 medical and health sciences ,Insulin resistance ,Internal medicine ,Diabetes mellitus ,Raltegravir Potassium ,Oxazines ,medicine ,Humans ,Pharmacology ,Ritonavir ,business.industry ,Insulin ,Raltegravir ,medicine.disease ,chemistry ,Insulin Resistance ,business ,Biomarkers - Abstract
OBJECTIVES An observational, prospective, cohort study was performed to assess changes in insulin sensitivity and serum leptin level after a switch from a ritonavir-boosted PI (PI/r) to raltegravir or dolutegravir in HIV-infected adults on stable combination ART (cART). METHODS Non-diabetic HIV-infected patients receiving suppressive cART including tenofovir disoproxil fumarate/emtricitabine plus one PI/r, who underwent a switch from the PI/r to raltegravir (group A) or dolutegravir (group B), were enrolled in the study. Serum levels of insulin, leptin and the homeostasis model assessment of insulin resistance (HOMA) index were evaluated during a 12 month follow-up. RESULTS Overall, 86 patients were enrolled: 45 patients were included in group A and 41 were included in group B. The mean age was 45.7 years and 74 (86%) patients were male. After 12 months of follow-up, a significant reduction in the mean concentration of leptin and insulin was reported both in group A [-0.61 ng/mL (P
- Published
- 2019