36 results on '"Institut für Mathematische Stochastik"'
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2. On ANOVA Decompositions of Kernels and Gaussian Random Field Paths
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David Ginsbourger, Nicolas Lenz, Nicolas Durrande, Dominic Schuhmacher, Olivier Roustant, Institute of Mathematical Statistics and Actuarial Science [Bern] (IMSV), University of Bern, IDIAP Research Institute, Méthodes d'Analyse Stochastique des Codes et Traitements Numériques (GdR MASCOT-NUM), Centre National de la Recherche Scientifique (CNRS), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT), Institut Henri Fayol (FAYOL-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Département Génie mathématique et industriel (FAYOL-ENSMSE), Ecole Nationale Supérieure des Mines de St Etienne-Institut Henri Fayol, Institut für Mathematische Stochastik, Georg-August-Universität Göttingen, Institut für Mathematische Stochastik, Georg-August-University [Göttingen]-Georg-August-University [Göttingen], Ronald Cools, Dirk Nuyens, Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Institut Henri Fayol, Georg-August-University = Georg-August-Universität Göttingen-Georg-August-University = Georg-August-Universität Göttingen, Département Décision en Entreprise : Modélisation, Optimisation (DEMO-ENSMSE), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Henri Fayol
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Mathematical optimization ,Gaussian processes ,Mathematics - Statistics Theory ,Statistics Theory (math.ST) ,010103 numerical & computational mathematics ,Conditional simulations ,Sobol' indices ,01 natural sciences ,Gaussian random field ,010104 statistics & probability ,symbols.namesake ,[STAT.ML]Statistics [stat]/Machine Learning [stat.ML] ,[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] ,Kriging ,FOS: Mathematics ,Applied mathematics ,Statistics::Methodology ,0101 mathematics ,Gaussian process ,Sobol' decomposition ,Mathematics ,[STAT.AP]Statistics [stat]/Applications [stat.AP] ,Probability (math.PR) ,Sobol sequence ,[STAT.TH]Statistics [stat]/Statistics Theory [stat.TH] ,Covariance ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,Numerical integration ,Statistics::Computation ,[MATH.MATH-PR]Mathematics [math]/Probability [math.PR] ,Tensor product ,Kernel (statistics) ,Covariance functions ,symbols ,Sensitivity analysis ,[STAT.ME]Statistics [stat]/Methodology [stat.ME] ,Mathematics - Probability - Abstract
The FANOVA (or "Sobol'-Hoeffding") decomposition of multivariate functions has been used for high-dimensional model representation and global sensitivity analysis. When the objective function f has no simple analytic form and is costly to evaluate, a practical limitation is that computing FANOVA terms may be unaffordable due to numerical integration costs. Several approximate approaches relying on random field models have been proposed to alleviate these costs, where f is substituted by a (kriging) predictor or by conditional simulations. In the present work, we focus on FANOVA decompositions of Gaussian random field sample paths, and we notably introduce an associated kernel decomposition (into 2^{2d} terms) called KANOVA. An interpretation in terms of tensor product projections is obtained, and it is shown that projected kernels control both the sparsity of Gaussian random field sample paths and the dependence structure between FANOVA effects. Applications on simulated data show the relevance of the approach for designing new classes of covariance kernels dedicated to high-dimensional kriging.
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- 2016
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3. A central limit theorem for the sample autocorrelations of a Lévy driven continuous time moving average process
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Serge Cohen, Alexander Lindner, Institut de Mathématiques de Toulouse UMR5219 (IMT), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut für Mathematische Stochastik, Technische Universität Braunschweig, Institut für Mathematische Stochastik, Institut für Mathematische Stochastik-Institut für Mathematische Stochastik, Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)
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Statistics and Probability ,sample autocovariance ,Asymptotic distribution ,continuous time moving average process ,01 natural sciences ,Lévy process ,sample mean ,010104 statistics & probability ,Moving average ,Statistics ,Applied mathematics ,estimation of the Hurst index ,0101 mathematics ,Mathematics ,Central limit theorem ,Hurst exponent ,fractional Lévy process ,Applied Mathematics ,010102 general mathematics ,Estimator ,Moving-average model ,[MATH.MATH-PR]Mathematics [math]/Probability [math.PR] ,Delta method ,limit theorem ,Statistics, Probability and Uncertainty ,Mathematics - Probability ,Bartlett's formula ,sample autocorrelation - Abstract
International audience; In this article we consider Lévy driven continuous time moving average processes observed on a lattice, which are stationary time series. We show asymptotic normality of the sample mean, the sample autocovariances and the sample autocorrelations. A comparison with the classical setting of discrete moving average time series shows that in the last case a correction term should be added to the classical Bartlett formula that yields the asymptotic variance. An application to the asymptotic normality of the estimator of the Hurst exponent of fractional Lévy processes is also deduced from these results.
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- 2013
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4. Total variation distance for discretely observed Lévy processes: A Gaussian approximation of the small jumps
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Céline Duval, Alexandra Carpentier, Ester Mariucci, Duval, Céline, Institut für Mathematische Stochastik, Fakultät für Mathematik, Otto-von-Guericke-Universität Magdeburg, Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145), Université Paris Descartes - Paris 5 (UPD5)-Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Centre National de la Recherche Scientifique (CNRS), and Institut für Mathematik, Universität Potsdam.
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Statistics and Probability ,[MATH.MATH-PR] Mathematics [math]/Probability [math.PR] ,Gaussian ,Gaussian approximation ,Mathematics - Statistics Theory ,01 natural sciences ,Measure (mathematics) ,Lévy process ,010104 statistics & probability ,Total variation ,symbols.namesake ,Total variation distance ,Statistical physics ,0101 mathematics ,Statistical hypothesis testing ,Mathematics ,[STAT.TH] Statistics [stat]/Statistics Theory [stat.TH] ,010102 general mathematics ,Statistical model ,[STAT.TH]Statistics [stat]/Statistics Theory [stat.TH] ,60G51, 62M99 (Primary), 60E99 (Secondary) ,[MATH.MATH-PR]Mathematics [math]/Probability [math.PR] ,Distribution (mathematics) ,Lévy processes ,Small jumps ,Metric (mathematics) ,symbols ,Statistics, Probability and Uncertainty ,Statistical test ,Mathematics - Probability - Abstract
It is common practice to treat small jumps of L\'evy processes as Wiener noise and thus to approximate its marginals by a Gaussian distribution. However, results that allow to quantify the goodness of this approximation according to a given metric are rare. In this paper, we clarify what happens when the chosen metric is the total variation distance. Such a choice is motivated by its statistical interpretation. If the total variation distance between two statistical models converges to zero, then no tests can be constructed to distinguish the two models which are therefore equivalent, statistically speaking. We elaborate a fine analysis of a Gaussian approximation for the small jumps of L\'evy processes with infinite L\'evy measure in total variation distance. Non asymptotic bounds for the total variation distance between $n$ discrete observations of small jumps of a L\'evy process and the corresponding Gaussian distribution is presented and extensively discussed. As a byproduct, new upper bounds for the total variation distance between discrete observations of L\'evy processes are provided. The theory is illustrated by concrete examples., Comment: Important and necessary changes have been made in this new version, this version supersedes version 1
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- 2021
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5. Ergodic decompositions of stationary max-stable processes in terms of their spectral functions
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Zakhar Kabluchko, Clément Dombry, Laboratoire de Mathématiques de Besançon (UMR 6623) (LMB), Université de Bourgogne (UB)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Institut für Mathematische Stochastik, and Georg-August-University [Göttingen]
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Statistics and Probability ,de Haan representation ,Pure mathematics ,Mixed moving maximum process ,01 natural sciences ,010104 statistics & probability ,Mixing (mathematics) ,Positive/null decomposition ,Ergodic theory ,Mathematics - Dynamical Systems ,0101 mathematics ,Mixing process ,Conservative/dissipative decomposition ,Ergodic process ,Max-stable random process ,Mathematics ,Applied Mathematics ,010102 general mathematics ,Ergodicity ,Null (mathematics) ,16. Peace & justice ,[MATH.MATH-PR]Mathematics [math]/Probability [math.PR] ,Flow (mathematics) ,Non-singular flow ,Modeling and Simulation ,Bounded function ,60G70 (Primary), 60G52, 60G60, 60G55, 60G10, 37A10, 37A25 (Secondary) ,Dissipative system ,Mathematics - Probability - Abstract
We revisit conservative/dissipative and positive/null decompositions of stationary max-stable processes. Originally, both decompositions were defined in an abstract way based on the underlying non-singular flow representation. We provide simple criteria which allow to tell whether a given spectral function belongs to the conservative/dissipative or positive/null part of the de Haan spectral representation. Specifically, we prove that a spectral function is null-recurrent iff it converges to $0$ in the Ces\`{a}ro sense. For processes with locally bounded sample paths we show that a spectral function is dissipative iff it converges to $0$. Surprisingly, for such processes a spectral function is integrable a.s. iff it converges to $0$ a.s. Based on these results, we provide new criteria for ergodicity, mixing, and existence of a mixed moving maximum representation of a stationary max-stable process in terms of its spectral functions. In particular, we study a decomposition of max-stable processes which characterizes the mixing property., Comment: 21 pages, no figures
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- 2017
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6. Least squares estimation in the monotone single index model
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Cécile Durot, Fadoua Balabdaoui, Hanna Jankowski, Institut für Mathematische Stochastik (IMS), Georg-August-University = Georg-August-Universität Göttingen, Fédération Parisienne de Modélisation Mathématique (FP2M), Centre National de la Recherche Scientifique (CNRS), Modélisation aléatoire de Paris X (MODAL'X), Université Paris Nanterre (UPN), and Georg-August-University [Göttingen]
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Statistics and Probability ,Mathematics - Statistics Theory ,Statistics Theory (math.ST) ,Type (model theory) ,01 natural sciences ,Least squares ,Combinatorics ,least squares ,010104 statistics & probability ,semi-parametric ,single-index model ,FOS: Mathematics ,Almost surely ,maximum likelihood ,0101 mathematics ,ComputingMilieux_MISCELLANEOUS ,Mathematics ,010102 general mathematics ,Estimator ,Function (mathematics) ,[STAT.TH]Statistics [stat]/Statistics Theory [stat.TH] ,Ridge (differential geometry) ,monotone ,Monotone polygon ,shape-constraints ,Rate of convergence - Abstract
We study the monotone single index model where a real response variable $Y $ is linked to a $d$-dimensional covariate $X$ through the relationship $E[Y | X] = \Psi_0(\alpha^T_0 X)$ almost surely. Both the ridge function, $\Psi_0$, and the index parameter, $\alpha_0$, are unknown and the ridge function is assumed to be monotone on its interval of support. Under some regularity conditions, without imposing a particular distribution on the regression error, we show the $n^{-1/3}$ rate of convergence in the $\ell_2$-norm for the least squares estimator of the bundled function $\psi_0({\alpha}^T_0 \cdot),$ and also that of the ridge function and the index separately. Furthermore, we show that the least squares estimator is nearly parametrically rate-adaptive to piecewise constant ridge functions., Comment: 54 pages
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- 2019
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7. The extinction problem for a class of distylous plant populations with sporophytic self-incompatibility
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Gerold Alsmeyer, Kilian Raschel, Institut für Mathematische Stochastik [Münster], Westfälische Wilhelms-Universität Münster (WWU), Institut Denis Poisson (IDP), Centre National de la Recherche Scientifique (CNRS)-Université de Tours (UT)-Université d'Orléans (UO), SFB 878, European Project: 759702,COMBINEPIC, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Université d'Orléans (UO)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Université d'Orléans (UO)
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Extinction probability ,Random walk ,Branching process ,Extinction, Biological ,01 natural sciences ,Models, Biological ,010305 fluids & plasmas ,Sub- and superharmonic function ,03 medical and health sciences ,Mathematics::Probability ,0103 physical sciences ,[MATH.MATH-CO]Mathematics [math]/Combinatorics [math.CO] ,Random environment ,Applied mathematics ,Pollination ,Markov jump process ,030304 developmental biology ,Mathematics ,0303 health sciences ,Applied Mathematics ,Probabilistic logic ,Self-Incompatibility in Flowering Plants ,Agricultural and Biological Sciences (miscellaneous) ,Diploidy ,Markov Chains ,Plant population ,[MATH.MATH-PR]Mathematics [math]/Probability [math.PR] ,Potential theory ,Modeling and Simulation ,Pollen ,MSC 2010 : 60J05 ,60H25 ,60K05 - Abstract
31 pages, 7 figures; International audience; In this paper, the extinction problem for a class of distylous plant populations is considered within the framework of certain nonhomogeneous nearest-neighbor random walks in the positive quadrant. For the latter, extinction means absorption at one of the axes. Despite connections with some classical probabilistic models (standard two-type Galton-Watson process, two-urn model), exact formulae for the probabilities of absorption seem to be difficult to come by and one must therefore resort to good approximations. In order to meet this task, we develop potential-theoretic tools and provide various sub- and super-harmonic functions which, for large initial populations, provide bounds which in particular improve those that have appeared earlier in the literature.
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- 2019
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8. Minimax Euclidean separation rates for testing convex hypotheses in $\mathbb{R}^{d}$
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Maurilio Gutzeit, Gilles Blanchard, Alexandra Carpentier, Institut für Mathematik [Potsdam], Universität Potsdam, and Institut für Mathematische Stochastik, Fakultät für Mathematik, Otto-von-Guericke-Universität Magdeburg
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Statistics and Probability ,Minimax hypothesis testing ,Gaussian ,Dimension (graph theory) ,Mathematics - Statistics Theory ,nonasymptotic minimax separation rate ,Statistics Theory (math.ST) ,01 natural sciences ,[INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] ,Combinatorics ,010104 statistics & probability ,symbols.namesake ,[INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG] ,[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] ,Euclidean geometry ,FOS: Mathematics ,Point (geometry) ,ddc:510 ,0101 mathematics ,Mathematics ,Gaussian sequence model ,010102 general mathematics ,Null (mathematics) ,Institut für Mathematik ,Regular polygon ,Minimax ,Euclidean distance ,60K35 ,symbols ,Statistics, Probability and Uncertainty ,62G10 - Abstract
We consider composite-composite testing problems for the expectation in the Gaussian sequence model where the null hypothesis corresponds to a convex subset $\mathcal{C}$ of $\mathbb{R}^d$. We adopt a minimax point of view and our primary objective is to describe the smallest Euclidean distance between the null and alternative hypotheses such that there is a test with small total error probability. In particular, we focus on the dependence of this distance on the dimension $d$ and the sample size/variance parameter $n$ giving rise to the minimax separation rate. In this paper we discuss lower and upper bounds on this rate for different smooth and non- smooth choices for $\mathcal{C}$.
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- 2018
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9. Dependent wild bootstrap for the empirical process
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Doukhan, Paul, Lang, Gabriel, Leucht, Anne, Neumann, Michael H., Analyse, Géométrie et Modélisation (AGM - UMR 8088), Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Centre National de la Recherche Scientifique (CNRS), Mathématiques et Informatique Appliquées (MIA-Paris), AgroParisTech-Institut National de la Recherche Agronomique (INRA), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], German Research Foundation DFG [NE 606/2-2], Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Centre National de la Recherche Scientifique (CNRS), Institut für Mathematische Stochastik, Technische Universität Braunschweig [Braunschweig], Institut für Mathematik, and Martin-Luther-Universität Halle Wittenberg (MLU)
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Absolute regularity ,V-statistics ,Kolmogorov-Smirnov test ,[SDV]Life Sciences [q-bio] ,test statistique ,méthode empirique ,statistical test ,empirical method ,time series ,bootstrap ,quantiles ,empirical process - Abstract
In this paper, we propose a model-free bootstrap method for the empirical process under absolute regularity. More precisely, consistency of an adapted version of the so-called dependent wild bootstrap, which was introduced by Shao () and is very easy to implement, is proved under minimal conditions on the tuning parameter of the procedure. We show how our results can be applied to construct confidence intervals for unknown parameters and to approximate critical values for statistical tests. In a simulation study, we investigate the size properties of a bootstrap-aided Kolmogorov-Smirnov test and show that our method is competitive to standard block bootstrap methods in finite samples.
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- 2015
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10. Testing monotonicity via local least concave majorants
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Nathalie Akakpo, Cécile Durot, Fadoua Balabdaoui, Laboratoire de Probabilités et Modèles Aléatoires (LPMA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut für Mathematische Stochastik (IMS), Georg-August-University = Georg-August-Universität Göttingen, CEntre de REcherches en MAthématiques de la DEcision (CEREMADE), Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Fédération Parisienne de Modélisation Mathématique (FP2M), Centre National de la Recherche Scientifique (CNRS), Modélisation aléatoire de Paris X (MODAL'X), Université Paris Nanterre (UPN), Centre National de la Recherche Scientifique (CNRS)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC), Georg-August-University [Göttingen], and Université Paris Dauphine-PSL-Centre National de la Recherche Scientifique (CNRS)
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Statistics and Probability ,Gaussian ,uniform separation rate ,Mathematics - Statistics Theory ,Monotonic function ,Statistics Theory (math.ST) ,Interval (mathematics) ,01 natural sciences ,Signal ,adaptivity ,010104 statistics & probability ,symbols.namesake ,0502 economics and business ,FOS: Mathematics ,Range (statistics) ,non-parametric ,0101 mathematics ,ComputingMilieux_MISCELLANEOUS ,050205 econometrics ,Mathematics ,05 social sciences ,White noise ,Variance (accounting) ,[STAT.TH]Statistics [stat]/Statistics Theory [stat.TH] ,monotonicity ,Regression ,[MATH.MATH-PR]Mathematics [math]/Probability [math.PR] ,[STAT]Statistics [stat] ,symbols ,Algorithm ,multiple test ,least concave majorant - Abstract
We propose a new testing procedure for detecting localized departures from monotonicity of a signal embedded in white noise. In fact, we perform simultaneously several tests that aim at detecting departures from concavity for the integrated signal over various intervals of different sizes and localizations. Each of these local tests relies on estimating the distance between the restriction of the integrated signal to some interval and its least concave majorant. Our test can be easily implemented and is proved to achieve the optimal uniform separation rate simultaneously for a wide range of H\"{o}lderian alternatives. Moreover, we show how this test can be extended to a Gaussian regression framework with unknown variance. A simulation study confirms the good performance of our procedure in practice., Comment: Published in at http://dx.doi.org/10.3150/12-BEJ496 the Bernoulli (http://isi.cbs.nl/bernoulli/) by the International Statistical Institute/Bernoulli Society (http://isi.cbs.nl/BS/bshome.htm)
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- 2014
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11. Shao's theorem on the maximum of standardized random walk increments for multidimensional arrays
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Zakhar Kabluchko, Axel Munk, Institut für Mathematische Stochastik, and Georg-August-University [Göttingen]
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Statistics and Probability ,02 engineering and technology ,Limiting ,Random walk ,01 natural sciences ,Regularization (mathematics) ,010104 statistics & probability ,0202 electrical engineering, electronic engineering, information engineering ,Calculus ,Applied mathematics ,020201 artificial intelligence & image processing ,Detection theory ,0101 mathematics ,Selection (genetic algorithm) ,Statistic ,Mathematics - Abstract
We generalize a theorem of Shao [Proc. Amer. Math. Soc. 123 (1995) 575–582] on the almost-sure limiting behavior of the maximum of standardized random walk increments to multidimensional arrays of i.i.d. random variables. The main difficulty is the absence of an appropriate strong approximation result in the multidimensional setting. The multiscale statistic under consideration was used recently for the selection of the regularization parameter in a number of statistical algorithms as well as for the multiscale signal detection. peerReviewed
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- 2010
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12. Limit distribution theory for maximum likelihood estimation of a log-concave density
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Jon A. Wellner, Kaspar Rufibach, Fadoua Balabdaoui, Institut für Mathematische Stochastik (IMS), Georg-August-University [Göttingen], CEntre de REcherches en MAthématiques de la DEcision (CEREMADE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Universität Zürich [Zürich] = University of Zurich (UZH), Department of Statistics, University of Washington [Seattle], University of Zurich, Balabdaoui, F, Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL), and institut für Sozial-und Präventivmedizin
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log--concave density estimation ,62G07, 62E20 ,shape constraints ,01 natural sciences ,Upper and lower bounds ,010104 statistics & probability ,[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] ,62N01 ,1804 Statistics, Probability and Uncertainty ,2613 Statistics and Probability ,maximum likelihood ,62N01, 62G20 (Primary) 62G05 (Secondary) ,62G20 ,ComputingMilieux_MISCELLANEOUS ,050205 econometrics ,Mathematics ,education.field_of_study ,Concave function ,strongly unimodal ,05 social sciences ,Mathematical analysis ,Estimator ,invelope process ,Density estimation ,nonparametric estimation ,16. Peace & justice ,unimodal ,[STAT]Statistics [stat] ,Statistics, Probability and Uncertainty ,Statistics and Probability ,Statistics::Theory ,integral of Brownian motion ,Population ,Asymptotic distribution ,Mathematics - Statistics Theory ,610 Medicine & health ,Statistics Theory (math.ST) ,Article ,lower bounds ,0502 economics and business ,FOS: Mathematics ,62G05 ,0101 mathematics ,asymptotic distribution ,education ,Pointwise ,mode estimation ,log-concave density estimation ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,[STAT.TH]Statistics [stat]/Statistics Theory [stat.TH] ,Minimax ,qualitative assumptions - Abstract
We find limiting distributions of the nonparametric maximum likelihood estimator (MLE) of a log-concave density, that is, a density of the form $f_0=\exp\varphi_0$ where $\varphi_0$ is a concave function on $\mathbb{R}$. The pointwise limiting distributions depend on the second and third derivatives at 0 of $H_k$, the "lower invelope" of an integrated Brownian motion process minus a drift term depending on the number of vanishing derivatives of $\varphi_0=\log f_0$ at the point of interest. We also establish the limiting distribution of the resulting estimator of the mode $M(f_0)$ and establish a new local asymptotic minimax lower bound which shows the optimality of our mode estimator in terms of both rate of convergence and dependence of constants on population values., Comment: Published in at http://dx.doi.org/10.1214/08-AOS609 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org)
- Published
- 2009
13. A second Marshall inequality in convex estimation
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Kaspar Rufibach, Fadoua Balabdaoui, Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL), institut für Sozial-und Präventivmedizin, Universität Zürich [Zürich] = University of Zurich (UZH), University of Zurich, Rufibach, K, Institut für Mathematische Stochastik (IMS), Georg-August-University [Göttingen], CEntre de REcherches en MAthématiques de la DEcision (CEREMADE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Dauphine-PSL, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)
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Statistics and Probability ,Kantorovich inequality ,Physics::Medical Physics ,610 Medicine & health ,Computer Science::Digital Libraries ,01 natural sciences ,Combinatorics ,010104 statistics & probability ,Marshall inequality ,[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] ,Calculus ,Log sum inequality ,1804 Statistics, Probability and Uncertainty ,2613 Statistics and Probability ,0101 mathematics ,ComputingMilieux_MISCELLANEOUS ,Mathematics ,Lemma (mathematics) ,Series (mathematics) ,Convex functions ,cubic polynomial ,Mathematics::Complex Variables ,010102 general mathematics ,[STAT.TH]Statistics [stat]/Statistics Theory [stat.TH] ,10060 Epidemiology, Biostatistics and Prevention Institute (EBPI) ,Density estimation ,[STAT]Statistics [stat] ,Monotone polygon ,Statistics, Probability and Uncertainty ,Convex function ,Jensen's inequality - Abstract
We prove a second Marshall inequality for adaptive convex density estimation via least squares. The result completes the first inequality proved recently by Dumbgen et al. [2007. Marshall's lemma for convex density estimation. IMS Lecture Notes—Monograph Series, submitted for publication. Preprint available at 〈 http://arxiv.org/abs/math.ST/0609277 〉 ], and is very similar to the original Marshall inequality in monotone estimation.
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- 2008
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14. Estimation of a k-monotone density: limit distribution theory and the Spline connection
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Balabdaoui, Fadoua, Wellner, Jon, Institut für Mathematische Stochastik (IMS), Georg-August-University [Göttingen], CEntre de REcherches en MAthématiques de la DEcision (CEREMADE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Department of Statistics, University of Washington [Seattle], Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL), and Balabdaoui, Fadoua
- Subjects
[STAT]Statistics [stat] ,k-monotone ,LSE ,[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] ,splines ,MLE ,[STAT.TH]Statistics [stat]/Statistics Theory [stat.TH] ,asymptotic distribution ,62G05, 60G99, 60G15, 62E20 ,completely monotone ,ComputingMilieux_MISCELLANEOUS ,[STAT] Statistics [stat] - Abstract
We study the asymptotic behavior of the Maximum Likelihood and Least Squares estimators of a $k-$monotone density $g_0$ at a fixed point $x_0$ when $k > 2$. In \mycite{balabwell:04a}, it was proved that both estimators exist and are splines of degree $k-1$ with simple knots. These knots, which are also the jump points of the $(k-1)-$st derivative of the estimators, cluster around a point $x_0 > 0$ under the assumption that $g_0$ has a continuous $k$-th derivative in a neighborhood of $x_0$ and $(-1)^k g^{(k)}_0(x_0) > 0$. If $\tau^{-}_n$ and $\tau^{+}_n$ are two successive knots, we prove that the random ``gap'' \ $\tau^{+}_n - \tau^{-}_n $ is $O_p(n^{-1/(2k+1)})$ for any $k > 2$ if a conjecture about the upper bound on the error in a particular Hermite interpolation via odd-degree splines holds. Based on the order of the gap, the asymptotic distribution of the Maximum Likelihood and Least Squares estimators can be established. We find that the $j-$th derivative of the estimators at $x_0$ converges at the rate $n^{-(k-j)/(2k+1)}$ for $j=0, \ldots, k-1$. The limiting distribution depends on an almost surely uniquely defined stochastic process $H_k$ that stays above (below) the $k$-fold integral of Brownian motion plus a deterministic drift, when $k$ is even (odd).
- Published
- 2007
15. Consistent estimation of a convex density at the origin
- Author
-
Fadoua Balabdaoui, Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL), Balabdaoui, Fadoua, Institut für Mathematische Stochastik (IMS), Georg-August-University [Göttingen], CEntre de REcherches en MAthématiques de la DEcision (CEREMADE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Dauphine-PSL, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)
- Subjects
Statistics and Probability ,Asymptotic distribution ,02 engineering and technology ,Fixed point ,01 natural sciences ,Least squares ,estimation at the boundary ,Combinatorics ,010104 statistics & probability ,[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] ,Statistics ,0202 electrical engineering, electronic engineering, information engineering ,62G07 ,0101 mathematics ,ComputingMilieux_MISCELLANEOUS ,Mathematics ,Hampel's problem ,Regular polygon ,Estimator ,020206 networking & telecommunications ,[STAT.TH]Statistics [stat]/Statistics Theory [stat.TH] ,Consistent Estimation ,[STAT] Statistics [stat] ,[STAT]Statistics [stat] ,Monotone polygon ,Distribution function ,Convex density ,Statistics, Probability and Uncertainty ,Brownian motion - Abstract
Motivated by Hampel’s birds migration problem, Groeneboom, Jongbloed, and Wellner [7] established the asymptotic distribution theory for the nonparametric Least Squares and Maximum Likelihood estimators of a convex and decreasing density, g 0, at a fixed point t 0 > 0. However, estimation of the distribution function of the birds’ resting times involves estimation of g′0 at 0, a boundary point at which the estimators are not consistent. In this paper, we focus on the Least Squares estimator, % MathType!MTEF!2!1!+-% feaafiart1ev1aaatCvAUfKttLearuqr1ngBPrgarmWu51MyVXgatC% vAUfeBSjuyZL2yd9gzLbvyNv2CaeHbd9wDYLwzYbItLDharyavP1wz% ZbItLDhis9wBH5garqqtubsr4rNCHbGeaGqiVu0Je9sqqrpepC0xbb% L8F4rqqrFfpeea0xe9Lq-Jc9vqaqpepm0xbba9pwe9Q8fs0-yqaqpe% pae9pg0FirpepeKkFr0xfr-xfr-xb9adbaqaaeGaciGaaiaabeqaam% aaeaqbaaGcbaGafm4zaCMbaGaadaWgaaWcbaGaemOBa4gabeaaaaa!3DC2! $$\tilde g_n $$ . Our goal is to show that consistent estimators of both g 0(0) and g′0(0) can be based solely on % MathType!MTEF!2!1!+-% feaafiart1ev1aaatCvAUfKttLearuqr1ngBPrgarmWu51MyVXgatC% vAUfeBSjuyZL2yd9gzLbvyNv2CaeHbd9wDYLwzYbItLDharyavP1wz% ZbItLDhis9wBH5garqqtubsr4rNCHbGeaGqiVu0Je9sqqrpepC0xbb% L8F4rqqrFfpeea0xe9Lq-Jc9vqaqpepm0xbba9pwe9Q8fs0-yqaqpe% pae9pg0FirpepeKkFr0xfr-xfr-xb9adbaqaaeGaciGaaiaabeqaam% aaeaqbaaGcbaGafm4zaCMbaGaadaWgaaWcbaGaemOBa4gabeaaaaa!3DC2! $$\tilde g_n $$ . Following the idea of Kulikov and Lopuhaa [14] in monotone estimation, we show that it suffices to take % MathType!MTEF!2!1!+-% feaafiart1ev1aaatCvAUfKttLearuqr1ngBPrgarmWu51MyVXgatC% vAUfeBSjuyZL2yd9gzLbvyNv2CaeHbd9wDYLwzYbItLDharyavP1wz% ZbItLDhis9wBH5garqqtubsr4rNCHbGeaGqiVu0Je9sqqrpepC0xbb% L8F4rqqrFfpeea0xe9Lq-Jc9vqaqpepm0xbba9pwe9Q8fs0-yqaqpe% pae9pg0FirpepeKkFr0xfr-xfr-xb9adbaqaaeGaciGaaiaabeqaam% aaeaqbaaGcbaGafm4zaCMbaGaadaWgaaWcbaGaemOBa4gabeaaaaa!3DC2! $$\tilde g_n $$ (n −α ) and % MathType!MTEF!2!1!+-% feaafiart1ev1aaatCvAUfKttLearuqr1ngBPrgarmWu51MyVXgatC% vAUfeBSjuyZL2yd9gzLbvyNv2CaeHbd9wDYLwzYbItLDharyavP1wz% ZbItLDhis9wBH5garqqtubsr4rNCHbGeaGqiVu0Je9sqqrpepC0xbb% L8F4rqqrFfpeea0xe9Lq-Jc9vqaqpepm0xbba9pwe9Q8fs0-yqaqpe% pae9pg0FirpepeKkFr0xfr-xfr-xb9adbaqaaeGaciGaaiaabeqaam% aaeaqbaaGcbaGafm4zaCMbaGGbauaadaWgaaWcbaGaemOBa4gabeaa% aaa!3DCD! $$\tilde g'_n $$ (n −α ), with α ∈ (0, 1/3). We establish their joint asymptotic distributions and show that α = 1/5 should be taken as it yields the fastest rates of convergence.
- Published
- 2007
16. Probabilistic forecasts, calibration and sharpness
- Author
-
Tilmann Gneiting, Fadoua Balabdaoui, Adrian E. Raftery, Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL), Department of Statistics, University of Washington [Seattle], Balabdaoui, Fadoua, Institut für Mathematische Stochastik (IMS), Georg-August-University [Göttingen], CEntre de REcherches en MAthématiques de la DEcision (CEREMADE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Dauphine-PSL, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)
- Subjects
Statistics and Probability ,010504 meteorology & atmospheric sciences ,Calibration (statistics) ,Scoring rule ,computer.software_genre ,01 natural sciences ,Cross-validation ,010104 statistics & probability ,[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] ,Econometrics ,0101 mathematics ,Probability integral transform ,Physics::Atmospheric and Oceanic Physics ,ComputingMilieux_MISCELLANEOUS ,0105 earth and related environmental sciences ,Mathematics ,Model selection ,Cumulative distribution function ,Probabilistic logic ,[STAT.TH]Statistics [stat]/Statistics Theory [stat.TH] ,Forecast verification ,[STAT] Statistics [stat] ,[STAT]Statistics [stat] ,Data mining ,Statistics, Probability and Uncertainty ,computer - Abstract
Probabilistic forecasts of a continuous variable take the form of predictive densities or predictive cumulative distribution functions. We propose a diagnostic approach to the evaluation of predictive performance that is based on the paradigm of {\sl maximizing the sharpness of the predictive distributions subject to calibration}. Calibration refers to the statistical consistency between the distributional forecasts and the observations and is a joint property of the predictions and the events that materialize. Sharpness refers to the concentration of the predictive distributions and is a property of the forecasts only. A simple theoretical framework phrased in terms of a game between nature and forecaster allows us to distinguish probabilistic calibration, exceedance calibration and marginal calibration. We propose and study tools for checking calibration and sharpness, among them the probability integral transform (PIT) histogram, marginal calibration plots, the sharpness diagram and proper scoring rules. The diagnostic approach is illustrated by an assessment and ranking of probabilistic forecasts of wind speed at the Stateline wind energy center in the U.S.~Pacific Northwest. In combination with cross-validation or in the time series context, our proposal provides very general, nonparametric alternatives to the use of information criteria for model diagnostics and model selection.
- Published
- 2007
17. Nonparametric estimation of a k-monotone density: A new asymptotic distribution theory
- Author
-
Balabdaoui, Fadoua, Institut für Mathematische Stochastik (IMS), Georg-August-University [Göttingen], University of Washington, and Jon A. Wellner(jaw@stat.washington.edu)
- Subjects
Splines ,Maximum Likelihood ,Minimax risk ,Shape constrained density ,K-monotone ,Iterative Spline algorithms ,Least Squares ,Maximum de vraisemblance ,Mouvement Brownien ,Interpolation ,Estimation non-paramétrique ,Brownian motion ,[MATH]Mathematics [math] ,Nonparametric estimation ,Moindres carrés ,Risque minimax - Abstract
In this dissertation, we consider the problem of nonparametric estimation of a k-monotone density on (0,∞) for a fixed integer k > 0 via the methods of Maximum Likelihood (ML) and Least Squares (LS). In the introduction, we present the original question that motivated us to look into this problem and also put other existing results in our general framework. In Chapter 2, we study the MLE and LSE of a k-monotone density based on n i.i.d. observations. Here, our study of the estimation problem is local in the sense that we only study the estimator and its derivatives at a fixed point x_0. Under some specific working assumptions, asymptotic minimax lower bounds for estimating g^{(j)}_0 (x_0), j=1,...,k-1, are derived. These bounds show that the rates of convergence of any estimator of g^{(j)}_0 (x_0) can be at most n^{-(k-j)/(2k+1)}. Furthermore, under the same working assumptions we prove that this rate is achieved by the j-th derivative of either the MLE or LSE if a certain conjecture concerning the error in a particular Hermite interpolation problem holds. To make the asymptotic distribution theory complete, the limiting distribution needs to be determined. This distribution depends on a very special stochastic process H_k which is almost surely uniquely defined on R. Chapter 3 is essentially devoted to an effort to prove the existence of such a process and to establish conditions characterizing it. It turns out that we can establish the existence and uniqueness of the process Hk if the same conjecture mentioned above with the finite sample problem holds. If Y_k is the (k-1) -fold integral of two-sided Brownian motion + k!/(2k)! t2k, then H_k is a random spline of degree 2k-1 that stays above Y_k if k is even and below it if k is odd. By applying a change of scale, our results include the special cases of estimation of monotone densities (k =1), and monotone and convex densities (k =2) for which an asymptotic distribution theory is available.Iterative spline algorithms developed to calculate the estimators and approximate the process H_k on finite intervals are described in Chapter 4. These algorithms exploit both the spline structure of the estimators and the process H_k as well as their characterizations and are based on iterative addition and deletion of the knot points.; Nous considérons l'estimation non-paramétrique d'une densité k-monotone définie sur (0,∞), pour un entier k > 0 donné, via les méthodes de maximum de vraisemblance et des moindres carrés qu'on note respectivement par MLE et LSE.Dans l'introduction, nous présentons tout d'abord la motivation principale derrière ce problème et nous faisons l'effort d'inclure dans le cadre général de notre travail les résultats asymptotiques qui étaient déjà établis pour les cas spéciaux k=1 et k=2. Ensuite, nous nous penchons sur l'étude des propriétés des MLE et LSE d'une densité k-monotone g_0 dans le cas où on dispose de n observations indépendantes générées de g_0. Notre étude asymptotique est locale, c'est-à-dire que nous nous intéressons uniquement aux propriétés asymptotiques des estimateurs et de leur dérivées à un point fixe, x_0. Sous certaines hypothèses que nous précisons, nous établissons d'abord les bornes inférieures minimax pour l'estimation des dérivées g^{(j)}_0(x_0), j=0,...,k-1. Les bornes obtenues indiquent que n^{-(k-j)/(2k+1)} est la vitesse de convergence optimale de n'importe quel estimateur non-paramétrique de g^{(j)}_0(x_0). Sous les mêmes hypothèses et si une certaine conjecture est vraie, nous démontrons que cette vitesse optimale est atteinte dans le cas des MLE et LSE.Pour compléter la théorie asymptotique des estimateurs et de leur dérivées au point x_0, nous passons à la dérivation de leurs distributions limites lorsque la taille de l'échantillon n tend vers l'infini. Il s'avère que ces distributions dépendent d'un processus stochastique bien particulier défini sur l'ensemble des réels R. On note ce processus par H_k Le 3ème chapitre est consacré essentiellement à l'existence et à l'unicité de H_k, ainsi qu'à sa caractérisation. Nous démontrons que si Y_k est la primitive (k-1)-ème d'un mouvement Brownien + k!/(2k)! t^{2k}, alors H_k reste au-dessus (au-dessous) de Y_k lorsque k est pair (impair). Un simple changement de variable suffit pour reconnaître que nos résultats comprennent les cas spéciaux k=1 et k=2 où le problème se réduit à l'estimation d'une densité décroissante et d'une densité décroissante et convexe respectivement. Pour ces cas-là, la théorie asymptotique des MLE et LES a été déjà établie.L'aspect algorithmique fait l'objet du 4ème chapitre. Les algorithmes de Splines itératifs (Iterative Spline algorithms) sont développés et implémentés afin de calculer les estimateurs et aussi pour obtenir une approximation du processus limite sur n'importe quel compact dans R. Ces algorithmes exploitent essentiellement la structure 'splineuse' des MLE, LSE et H_k, et se basent ainsi sur la suppression et l'addition itératives des noeuds de certains Splines aléatoires.
- Published
- 2004
18. Estimation non-paramétrique d'une densité k-monotone: Une nouvelle théorie de distribution asymptotique
- Author
-
Balabdaoui, Fadoua, Institut für Mathematische Stochastik (IMS), Georg-August-University [Göttingen], University of Washington, and Jon A. Wellner(jaw@stat.washington.edu)
- Subjects
Splines ,Maximum Likelihood ,Minimax risk ,Shape constrained density ,K-monotone ,Iterative Spline algorithms ,Least Squares ,Maximum de vraisemblance ,Mouvement Brownien ,Interpolation ,Estimation non-paramétrique ,Brownian motion ,[MATH]Mathematics [math] ,Nonparametric estimation ,Moindres carrés ,Risque minimax - Abstract
In this dissertation, we consider the problem of nonparametric estimation of a k-monotone density on (0,∞) for a fixed integer k > 0 via the methods of Maximum Likelihood (ML) and Least Squares (LS). In the introduction, we present the original question that motivated us to look into this problem and also put other existing results in our general framework. In Chapter 2, we study the MLE and LSE of a k-monotone density based on n i.i.d. observations. Here, our study of the estimation problem is local in the sense that we only study the estimator and its derivatives at a fixed point x_0. Under some specific working assumptions, asymptotic minimax lower bounds for estimating g^{(j)}_0 (x_0), j=1,...,k-1, are derived. These bounds show that the rates of convergence of any estimator of g^{(j)}_0 (x_0) can be at most n^{-(k-j)/(2k+1)}. Furthermore, under the same working assumptions we prove that this rate is achieved by the j-th derivative of either the MLE or LSE if a certain conjecture concerning the error in a particular Hermite interpolation problem holds. To make the asymptotic distribution theory complete, the limiting distribution needs to be determined. This distribution depends on a very special stochastic process H_k which is almost surely uniquely defined on R. Chapter 3 is essentially devoted to an effort to prove the existence of such a process and to establish conditions characterizing it. It turns out that we can establish the existence and uniqueness of the process Hk if the same conjecture mentioned above with the finite sample problem holds. If Y_k is the (k-1) -fold integral of two-sided Brownian motion + k!/(2k)! t2k, then H_k is a random spline of degree 2k-1 that stays above Y_k if k is even and below it if k is odd. By applying a change of scale, our results include the special cases of estimation of monotone densities (k =1), and monotone and convex densities (k =2) for which an asymptotic distribution theory is available.Iterative spline algorithms developed to calculate the estimators and approximate the process H_k on finite intervals are described in Chapter 4. These algorithms exploit both the spline structure of the estimators and the process H_k as well as their characterizations and are based on iterative addition and deletion of the knot points.; Nous considérons l'estimation non-paramétrique d'une densité k-monotone définie sur (0,∞), pour un entier k > 0 donné, via les méthodes de maximum de vraisemblance et des moindres carrés qu'on note respectivement par MLE et LSE.Dans l'introduction, nous présentons tout d'abord la motivation principale derrière ce problème et nous faisons l'effort d'inclure dans le cadre général de notre travail les résultats asymptotiques qui étaient déjà établis pour les cas spéciaux k=1 et k=2. Ensuite, nous nous penchons sur l'étude des propriétés des MLE et LSE d'une densité k-monotone g_0 dans le cas où on dispose de n observations indépendantes générées de g_0. Notre étude asymptotique est locale, c'est-à-dire que nous nous intéressons uniquement aux propriétés asymptotiques des estimateurs et de leur dérivées à un point fixe, x_0. Sous certaines hypothèses que nous précisons, nous établissons d'abord les bornes inférieures minimax pour l'estimation des dérivées g^{(j)}_0(x_0), j=0,...,k-1. Les bornes obtenues indiquent que n^{-(k-j)/(2k+1)} est la vitesse de convergence optimale de n'importe quel estimateur non-paramétrique de g^{(j)}_0(x_0). Sous les mêmes hypothèses et si une certaine conjecture est vraie, nous démontrons que cette vitesse optimale est atteinte dans le cas des MLE et LSE.Pour compléter la théorie asymptotique des estimateurs et de leur dérivées au point x_0, nous passons à la dérivation de leurs distributions limites lorsque la taille de l'échantillon n tend vers l'infini. Il s'avère que ces distributions dépendent d'un processus stochastique bien particulier défini sur l'ensemble des réels R. On note ce processus par H_k Le 3ème chapitre est consacré essentiellement à l'existence et à l'unicité de H_k, ainsi qu'à sa caractérisation. Nous démontrons que si Y_k est la primitive (k-1)-ème d'un mouvement Brownien + k!/(2k)! t^{2k}, alors H_k reste au-dessus (au-dessous) de Y_k lorsque k est pair (impair). Un simple changement de variable suffit pour reconnaître que nos résultats comprennent les cas spéciaux k=1 et k=2 où le problème se réduit à l'estimation d'une densité décroissante et d'une densité décroissante et convexe respectivement. Pour ces cas-là, la théorie asymptotique des MLE et LES a été déjà établie.L'aspect algorithmique fait l'objet du 4ème chapitre. Les algorithmes de Splines itératifs (Iterative Spline algorithms) sont développés et implémentés afin de calculer les estimateurs et aussi pour obtenir une approximation du processus limite sur n'importe quel compact dans R. Ces algorithmes exploitent essentiellement la structure 'splineuse' des MLE, LSE et H_k, et se basent ainsi sur la suppression et l'addition itératives des noeuds de certains Splines aléatoires.
- Published
- 2004
19. On minimal representations of shallow ReLU networks.
- Author
-
Dereich S and Kassing S
- Subjects
- Neural Networks, Computer
- Abstract
The realization function of a shallow ReLU network is a continuous and piecewise affine function f:R
d →R, where the domain Rd is partitioned by a set of n hyperplanes into cells on which f is affine. We show that the minimal representation for f uses either n, n+1 or n+2 neurons and we characterize each of the three cases. In the particular case, where the input layer is one-dimensional, minimal representations always use at most n+1 neurons but in all higher dimensional settings there are functions for which n+2 neurons are needed. Then we show that the set of minimal networks representing f forms a C∞ -submanifold M and we derive the dimension and the number of connected components of M. Additionally, we give a criterion for the hyperplanes that guarantees that a continuous, piecewise affine function is the realization function of an appropriate shallow ReLU network., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Ltd. All rights reserved.)- Published
- 2022
- Full Text
- View/download PDF
20. Enhanced normograms and pregnancy outcome analysis in nonhuman primate developmental toxicity studies.
- Author
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Grossmann H, Weinbauer GF, Baker A, Fuchs A, and Luetjens CM
- Subjects
- Animals, Embryonic Development, Female, Fetal Development, Kaplan-Meier Estimate, Macaca fascicularis, Pregnancy, Nomograms, Pregnancy Outcome, Toxicity Tests statistics & numerical data
- Abstract
The incidence of spontaneous pregnancy/infant losses is highly variable in long-tailed macaques (cynomolgus monkey), making it potentially difficult to ascertain test item-related effects in developmental toxicity studies. Therefore, pregnancy normograms had been developed by Jarvis et al. [1] to aid in the distinction of normal (e.g. test facility background) versus non-normal pregnancy outcomes. These normograms were mostly derived from embryo-fetal development studies and from PPND studies with a postnatal phase limited to seven days. However, the enhanced pre- and postnatal developmental (ePPND) study paradigm has essentially replaced these former study types. This work aims at providing enhanced normograms (e-normograms) in the context of regulatory ePPND studies. Survival functions for the prenatal phase (286 control pregnancies) and the postnatal phase (222 live infants) were estimated using the Kaplan-Meier estimator. Normograms were generated from survival curves and pseudo-study simulations. Data were available from two test facilities with comparable EU-compliant animal husbandry. Pregnancy duration/outcome as well as survival functions did not differ significantly between test facilities indicating that this husbandry system yields comparable developmental observations across different test facilities, at least in this NHP species. These novel e-normograms were developed for pregnant long-tailed macaques and provide an extended postnatal period up to three months, a new concept of separate normograms for the prenatal and the postnatal period, specific information on the perinatal phase events, a prediction of expected number of live infants for group size management, and the option to evaluate effects on pregnancy duration through distinction of live births and infant losses., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
21. The Emergent Yo-yo Movement of Nuclei Driven by Cytoskeletal Remodeling in Pseudo-synchronous Mitotic Cycles.
- Author
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Lv Z, Rosenbaum J, Mohr S, Zhang X, Kong D, Preiß H, Kruss S, Alim K, Aspelmeier T, and Großhans J
- Subjects
- Animals, Drosophila melanogaster embryology, Cell Nucleus physiology, Cytoskeleton physiology, Drosophila melanogaster physiology, Embryo, Nonmammalian physiology, Mitosis physiology, Morphogenesis
- Abstract
Many aspects in tissue morphogenesis are attributed to a collective behavior of the participating cells. Yet, the mechanism for emergence of dynamic tissue behavior is not well understood. Here, we report that the "yo-yo"-like nuclear movement in the Drosophila syncytial embryo displays emergent features indicative of collective behavior. Following mitosis, the array of nuclei moves away from the wave front by several nuclear diameters only to return to its starting position about 5 min later. Based on experimental manipulations and numerical simulations, we find that the ensemble of elongating and isotropically oriented spindles, rather than individual spindles, is the main driving force for anisotropic nuclear movement. ELMO-dependent F-actin restricts the time for the forward movement and ELMO- and dia-dependent F-actin is essential for the return movement. Our study provides insights into how the interactions among the cytoskeleton as individual elements lead to collective movement of the nuclear array on a macroscopic scale., Competing Interests: Declaration of Interests The authors declare no competing interests., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
22. [Cognition in children with social anxiety disorder experiencing stress].
- Author
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Schwarz J, Schreiber F, Kühnemund M, Weber C, Stangier U, and Melfsen S
- Subjects
- Adaptation, Psychological, Adolescent, Child, Humans, Cognition, Phobia, Social complications, Phobia, Social psychology, Stress, Psychological complications
- Abstract
Cognition in children with social anxiety disorder experiencing stress Abstract. Empirical data on cognitions of children with social anxiety disorder (SAD) are inconclusive. Objective: The present study examines the significance of cognition in children with SAD. Method: Thirty children suffering from SAD and 30 control children free of diagnosis (HC) aged between 9 and 15 years took part in an experiment. Their cognition was assessed before, during, and after a stress-inducing social situation. The assessment method was a self-report measurement. Coping perception was also assessed. Results: Children with SAD did not report a higher level of negative or coping cognition than those in the HC group. An interaction was apparent on the positive cognition scale: Older children (11-12 or 13-15 years) with SAD reported less positive cognition than those in the HC group, and younger children with SAD (9-10 years) reported more than those in the HC group. No group differences were found for perceived coping. Conclusions: The findings are important to the cognitive model and for the psychological treatment of SAD in children.
- Published
- 2020
- Full Text
- View/download PDF
23. The extinction problem for a distylous plant population with sporophytic self-incompatibility.
- Author
-
Alsmeyer G and Raschel K
- Subjects
- Diploidy, Markov Chains, Extinction, Biological, Models, Biological, Pollen genetics, Pollination physiology, Self-Incompatibility in Flowering Plants physiology
- Abstract
In this paper, the extinction problem for a class of distylous plant populations is considered within the framework of certain nonhomogeneous nearest-neighbor random walks in the positive quadrant. For the latter, extinction means absorption at one of the axes. Despite connections with some classical probabilistic models (standard two-type Galton-Watson process, two-urn model), exact formulae for the probabilities of absorption seem to be difficult to come by and one must therefore resort to good approximations. In order to meet this task, we develop potential-theoretic tools and provide various sub- and super-harmonic functions which, for large initial populations, provide bounds which in particular improve those that have appeared earlier in the literature.
- Published
- 2019
- Full Text
- View/download PDF
24. Design and analysis of three-arm trials with negative binomially distributed endpoints.
- Author
-
Mütze T, Munk A, and Friede T
- Subjects
- Computer Simulation, Dimethyl Fumarate therapeutic use, Humans, Immunosuppressive Agents therapeutic use, Magnetic Resonance Imaging, Monte Carlo Method, Multiple Sclerosis drug therapy, Multiple Sclerosis pathology, Placebos, Sample Size, Clinical Trials as Topic, Endpoint Determination, Models, Statistical, Research Design
- Abstract
A three-arm clinical trial design with an experimental treatment, an active control, and a placebo control, commonly referred to as the gold standard design, enables testing of non-inferiority or superiority of the experimental treatment compared with the active control. In this paper, we propose methods for designing and analyzing three-arm trials with negative binomially distributed endpoints. In particular, we develop a Wald-type test with a restricted maximum-likelihood variance estimator for testing non-inferiority or superiority. For this test, sample size and power formulas as well as optimal sample size allocations will be derived. The performance of the proposed test will be assessed in an extensive simulation study with regard to type I error rate, power, sample size, and sample size allocation. For the purpose of comparison, Wald-type statistics with a sample variance estimator and an unrestricted maximum-likelihood estimator are included in the simulation study. We found that the proposed Wald-type test with a restricted variance estimator performed well across the considered scenarios and is therefore recommended for application in clinical trials. The methods proposed are motivated and illustrated by a recent clinical trial in multiple sclerosis. The R package ThreeArmedTrials, which implements the methods discussed in this paper, is available on CRAN., (Copyright © 2015 John Wiley & Sons, Ltd.)
- Published
- 2016
- Full Text
- View/download PDF
25. STOCHASTIC SOLUTIONS FOR FRACTIONAL WAVE EQUATIONS.
- Author
-
Meerschaert MM, Schilling RL, and Sikorskii A
- Abstract
A fractional wave equation replaces the second time derivative by a Caputo derivative of order between one and two. In this paper, we show that the fractional wave equation governs a stochastic model for wave propagation, with deterministic time replaced by the inverse of a stable subordinator whose index is one half the order of the fractional time derivative.
- Published
- 2015
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26. Expanding pedestrian injury risk to the body region level: how to model passive safety systems in pedestrian injury risk functions.
- Author
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Niebuhr T, Junge M, and Achmus S
- Subjects
- Abbreviated Injury Scale, Acceleration, Craniocerebral Trauma prevention & control, Facial Injuries prevention & control, Hip Injuries prevention & control, Humans, Injury Severity Score, Leg Injuries prevention & control, Neck Injuries prevention & control, Risk Assessment methods, Thoracic Injuries prevention & control, Accidents, Traffic statistics & numerical data, Models, Biological, Protective Devices, Walking injuries
- Abstract
Objective: Assessment of the effectiveness of advanced driver assistance systems (ADAS) plays a crucial role in accident research. A common way to evaluate the effectiveness of new systems is to determine the potentials for injury severity reduction. Because injury risk functions describe the probability of an injury of a given severity conditional on a technical accident severity (closing speed, delta V, barrier equivalent speed, etc.), they are predestined for such evaluations., Methods: Recent work has stated an approach on how to model the pedestrian injury risk in pedestrian-to-passenger car accidents as a family of functions. This approach gave explicit and easily interpretable formulae for the injury risk conditional on the closing speed of the car. These results are extended to injury risk functions for pedestrian body regions. Starting with a double-checked German In-depth Accident Study (GIDAS) pedestrian-to-car accident data set (N = 444) and a functional-anatomical definition of the body regions, investigations on the influence of specific body regions on the overall injury severity will be presented. As the measure of injury severity, the ISSx, a rescaled version of the well-known Injury Severity Score (ISS), was used. Though traditional ISS is computed by summation of the squares of the 3 most severe injured body regions, ISSx is computed by the summation of the exponentials of the Abbreviated Injury Scale (AIS) severities of the 3 most severely injured body regions. The exponentials used are scaled to fit the ISS range of values between 0 and 75., Results: Three body regions (head/face/neck, thorax, hip/legs) clearly dominated abdominal and upper extremity injuries; that is, the latter 2 body regions had no influence at all on the overall injury risk over the range of technical accident severities. Thus, the ISSx is well described by use of the injury codes from the same body regions for any pedestrian injury severity. As a mathematical consequence, the ISSx becomes explicitly decomposable into the 3 body regions and so are the risk functions as body region-specific risk functions. The risk functions for each body region are stated explicitly for different injury severity levels and compared to the real-world accident data., Conclusions: The body region-specific risk functions can then be used to model the effect of improved passive safety systems. These modified body region-specific injury risk functions are aggregated to a new pedestrian injury risk function. Passive safety systems can therefore be modeled in injury risk functions for the first time. A short example on how the results can be used for assessing the effectiveness of new driver assistance systems concludes the article.
- Published
- 2015
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27. Design and semiparametric analysis of non-inferiority trials with active and placebo control for censored time-to-event data.
- Author
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Kombrink K, Munk A, and Friede T
- Subjects
- Computer Simulation, Depressive Disorder, Major drug therapy, Humans, Research Design, Sample Size, Algorithms, Data Interpretation, Statistical, Models, Statistical, Randomized Controlled Trials as Topic methods
- Abstract
The clinical trial design including a test treatment, an active control and a placebo is called the gold standard design. In this paper, we develop a statistical method for planning and evaluating non-inferiority trials with gold standard design for right-censored time-to-event data. We consider both lost to follow-up and administrative censoring. We present a semiparametric approach that only assumes the proportionality of the hazard functions. In particular, we develop an algorithm for calculating the minimal total sample size and its optimal allocation to treatment groups such that a desired power can be attained for a specific parameter constellation under the alternative. For the purpose of sample size calculation, we assume the endpoints to be Weibull distributed. By means of simulations, we investigate the actual type I error rate, power and the accuracy of the calculated sample sizes. Finally, we compare our procedure with a previously proposed procedure assuming exponentially distributed event times. To illustrate our method, we consider a double-blinded, randomized, active and placebo controlled trial in major depression., (Copyright © 2013 John Wiley & Sons, Ltd.)
- Published
- 2013
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28. A mathematical view on the decoupled sites representation.
- Author
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Martini JW and Ullmann GM
- Subjects
- Binding Sites, Hydrogen-Ion Concentration, Thermodynamics, Models, Chemical, Proteins chemistry, Protons
- Abstract
The decoupled sites representation (DSR) is a theoretical instrument which allows to regard complex pH titration curves of biomolecules with several interacting proton binding sites as composition of isolated, non-interacting sites, each with a standard Henderson-Hasselbalch titration curve. In this work, we present the mathematical framework in which the DSR is embedded and give mathematical proofs for several statements in the periphery of the DSR. These proofs also identify exceptions. To apply the DSR to any molecule, it is necessary to extend the set of binding energies from R to a stripe within C. An important observation in this context is that even positive interaction energies (repulsion) between the binding sites will not guarantee real binding energies in the decoupled system, at least if the molecule has more than four proton binding sites. Moreover, we show that for a given overall titration curve it is not only possible to find a corresponding system with an interaction energy of zero but with any arbitrary fix interaction energy. This result also effects practical work as it shows that for any given titration curve, there is an infinite number of corresponding hypothetical molecules. Furthermore, this implies that--using a common definition of cooperative binding on the level of interaction energies--a meaningful measure of cooperativity between the binding sites cannot be defined solely on the basis of the overall titration. Consequently, all measures of cooperativity based on the overall binding curve do not measure the type of cooperativity commonly defined on the basis of interaction energies. Understanding the DSR mathematically provides the basis of transferring the DSR to biomolecules with different types of interacting ligands, such as protons and electrons, which play an important role within electron transport chains like in photosynthesis.
- Published
- 2013
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29. Pedestrian injury risk functions based on contour lines of equal injury severity using real world pedestrian/passenger-car accident data.
- Author
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Niebuhr T, Junge M, and Achmus S
- Abstract
Injury risk assessment plays a pivotal role in the assessment of the effectiveness of Advanced Driver Assistance Systems (ADAS) as they specify the injury reduction potential of the system. The usual way to describe injury risks is by use of injury risk functions, i.e. specifying the probability of an injury of a given severity occurring at a specific technical accident severity (collision speed). A method for the generation of a family of risk functions for different levels of injury severity is developed. The injury severity levels are determined by use of a rescaled version of the Injury Severity Score (ISS) namely the ISSx. The injury risk curves for each collision speed is then obtained by fixing the boundary conditions and use of a case-by-case validated GIDAS subset of pedestrian-car accidents (N=852). The resultant functions are of exponential form as opposed to the frequently used logistic regression form. The exponential approach in combination with the critical speed value creates a new injury risk pattern better fitting for high speed/high energy crashes. Presented is a family of pedestrian injury risk functions for an arbitrary injury severity. Thus, the effectiveness of an ADAS can be assessed for mitigation of different injury severities using the same injury risk function and relying on the internal soundness of the risk function with regard to different injury severity levels. For the assessment of emergency braking ADAS, a Zone of Effective Endangerment Increase (ZEEI), the speed interval in which a one percent speed increase results at least in a one percent of injury risk increase, is defined. The methodology presented is kept in such general terms that a direct adaption to other accident configurations is easily done.
- Published
- 2013
30. Feller processes: the next generation in modeling. Brownian motion, Lévy processes and beyond.
- Author
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Böttcher B
- Subjects
- Geology methods, Humans, Markov Chains, Models, Biological, Models, Economic, Models, Statistical, Models, Theoretical, Monte Carlo Method, Oscillometry, Physics methods, Poisson Distribution, Software, Stochastic Processes, Temperature, Motion
- Abstract
We present a simple construction method for Feller processes and a framework for the generation of sample paths of Feller processes. The construction is based on state space dependent mixing of Lévy processes. Brownian Motion is one of the most frequently used continuous time Markov processes in applications. In recent years also Lévy processes, of which Brownian Motion is a special case, have become increasingly popular. Lévy processes are spatially homogeneous, but empirical data often suggest the use of spatially inhomogeneous processes. Thus it seems necessary to go to the next level of generalization: Feller processes. These include Lévy processes and in particular brownian motion as special cases but allow spatial inhomogeneities. Many properties of Feller processes are known, but proving the very existence is, in general, very technical. Moreover, an applicable framework for the generation of sample paths of a Feller process was missing. We explain, with practitioners in mind, how to overcome both of these obstacles. In particular our simulation technique allows to apply Monte Carlo methods to Feller processes.
- Published
- 2010
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31. The cellular basis of cell sorting kinetics.
- Author
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Voss-Böhme A and Deutsch A
- Subjects
- Algorithms, Animals, Cell Adhesion, Humans, Kinetics, Models, Biological, Models, Statistical, Models, Theoretical, Probability, Surface Properties, Surface Tension, Cell Movement genetics, Cell Separation
- Abstract
Cell sorting is a dynamical cooperative phenomenon that is fundamental for tissue morphogenesis and tissue homeostasis. According to Steinberg's differential adhesion hypothesis, the structure of sorted cell aggregates is determined by physical characteristics of the respective tissues, the tissue surface tensions. Steinberg postulated that tissue surface tensions result from quantitative differences in intercellular adhesion. Several experiments in cell cultures as well as in developing organisms support this hypothesis. The question of how tissue surface tension might result from differential adhesion was addressed in some theoretical models. These models describe the cellular interdependence structure once the temporal evolution has stabilized. In general, these models are capable of reproducing sorted patterns. However, the model dynamics at the cellular scale are defined implicitly and are not well-justified. The precise mechanism describing how differential adhesion generates the observed sorting kinetics at the tissue level is still unclear. It is necessary to formulate the concepts of cell level kinetics explicitly. Only then it is possible to understand the temporal development at the cellular and tissue scales. Here we argue that individual cell mobility is reduced the more the cells stick to their neighbors. We translate this assumption into a precise mathematical model which belongs to the class of stochastic interacting particle systems. Analyzing this model, we are able to predict the emergent sorting behavior at the population level. We describe qualitatively the geometry of cell segregation depending on the intercellular adhesion parameters. Furthermore, we derive a functional relationship between intercellular adhesion and surface tension and highlight the role of cell mobility in the process of sorting. We show that the interaction between the cells and the boundary of a confining vessel has a major impact on the sorting geometry., ((c) 2009 Elsevier Ltd. All rights reserved.)
- Published
- 2010
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32. The assessment of non-inferiority in a gold standard design with censored, exponentially distributed endpoints.
- Author
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Mielke M, Munk A, and Schacht A
- Subjects
- Data Interpretation, Statistical, Depression, Humans, Models, Statistical, Sample Size, Biomarkers, Controlled Clinical Trials as Topic methods
- Abstract
The objective of this paper is to develop statistical methodology for non-inferiority hypotheses to censored, exponentially distributed time to event endpoints. Motivated by a recent clinical trial in depression, we consider a gold standard design where a test group is compared with an active reference and with a placebo group. The test problem is formulated in terms of a retention of effect hypothesis. Thus, the proposed Wald-type test procedure assures that the effect of the test group is better than a pre-specified proportion Delta of the treatment effect of the reference group compared with the placebo group. A sample size allocation rule to achieve optimal power is presented, which only depends on the pre-specified Delta and the probabilities for the occurrence of censoring. In addition, a pretest is presented for either the reference or the test group to ensure assay sensitivity in the complete test procedure. The actual type I error and the sample size formula of the proposed tests are explored asymptotically by means of a simulation study showing good small sample characteristics. To illustrate the procedure a randomized, double blind clinical trial in depression is evaluated. An R-package for implementation of the proposed tests and for sample size determination accompanies this paper on the author's web page., (Copyright 2008 John Wiley & Sons, Ltd.)
- Published
- 2008
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33. On identifiability in capture-recapture models.
- Author
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Holzmann H, Munk A, and Zucchini W
- Subjects
- Animals, Animals, Wild, Population Dynamics, Statistics, Nonparametric, Biometry methods, Models, Statistical
- Abstract
We study the issue of identifiability of mixture models in the context of capture-recapture abundance estimation for closed populations. Such models are used to take account of individual heterogeneity in capture probabilities, but their validity was recently questioned by Link (2003, Biometrics 59, 1123-1130) on the basis of their nonidentifiability. We give a general criterion for identifiability of the mixing distribution, and apply it to establish identifiability within families of mixing distributions that are commonly used in this context, including finite and beta mixtures. Our analysis covers binomial and geometrically distributed outcomes. In an example we highlight the difference between the identifiability issue considered here and that in classical binomial mixture models.
- Published
- 2006
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34. Non-parametric assessment of non-inferiority with censored data.
- Author
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Freitag G, Lange S, and Munk A
- Subjects
- Computer Simulation, Confidence Intervals, Humans, Odds Ratio, Proportional Hazards Models, Research Design, Survival Analysis, Therapeutic Equivalency, Treatment Outcome, Controlled Clinical Trials as Topic methods, Data Interpretation, Statistical, Models, Statistical, Statistics, Nonparametric
- Abstract
We suggest non-parametric tests for showing non-inferiority of a new treatment compared to a standard therapy when data are censored. To this end the difference and the odds ratio curves of the entire survivor functions over a certain time period are considered. Two asymptotic approaches for solving these testing problems are investigated, which are based on bootstrap approximations. The performance of the test procedures is investigated in a simulation study, and some guidance on which test to use in specific situations is derived. The proposed methods are applied to a trial in which two thrombolytic agents for the treatment on acute myocardial infarction were compared, and to a study on irradiation therapies for advanced non-small-cell lung cancer. Non-inferiority over a large time period of the study can be shown in both cases., (Copyright 2005 John Wiley & Sons, Ltd.)
- Published
- 2006
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35. A nonlinear model of stress hormone levels in rats-the interaction between pollution and parasites.
- Author
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Klar B and Sures B
- Subjects
- Animals, Biomarkers blood, Male, Nonlinear Dynamics, Rats, Rats, Wistar, Cadmium Chloride toxicity, Environmental Pollutants toxicity, Helminthiasis, Animal blood, Hydrocortisone blood, Moniliformis
- Abstract
The impact of an infection with a parasite and a simultaneous cadmium exposure on the stress hormone levels of rats was studied. To this end, we introduce a nonlinear heteroscedastic model, which is able to describe the temporal evolution of cortisol concentrations in groups of rats treated by cadmium or parasite infection. A thorough analysis gives strong evidence that parasitic infection and cadmium exposure affect the stress hormone level of rats in an additive manner. Therefore, the host's response to environmental pollution should be studied in relation to parasite infections., (Copyright 2003 Elsevier Inc.)
- Published
- 2004
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36. Cost-minimal immunization in the Greenwood epidemic model.
- Author
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Hinderer K and Müller A
- Subjects
- Costs and Cost Analysis, Humans, Models, Biological, Models, Economic, Disease Outbreaks, Immunization economics, Mathematics
- Abstract
In the present paper, we extend the investigations of Lefèvre [1] and Dayananda and Hogarth [2] to a model with a more realistic economical setting and with a more flexible transition mechanism for the population. The new aspects include terminal costs, a stopping opportunity, discounting, and a scheme for generating a wealth of specific probability distributions, not only for the immunization step, but also for the infection step. In the second part of the paper, we also include fixed costs. While showing that our model without fixed costs has essentially the same simple solution as the model by Lefèvre [1] and Dayananda and Hogarth [2], the largest part of the paper deals with new structural properties such as an asymptotic behavior for large horizon and concavity of the minimal cost functions. The solutions in the model with and without fixed costs differ considerably. The main tool of our investigation is the theory of Markovian decision processes.
- Published
- 1997
- Full Text
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