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1. Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation

Author

Stéphanie Badiou, Christophe Normand, Yves Rinato, Timo Kanninen, Abdelhamid Barakat, Jean Frederic Brun, Florin Grigorescu, Jean-Marie Robine, Serghey Litvinov, Michel Pugeat, Ramon Gomis, Josep Maria Macias, Nicoleta Baculescu, Catalina Poiana, Carmen Emanuela Georgescu, Sara Haydar, Corin Badiu, Elza Khusnutdinova, Thibault Sutra, Yannick Cogne, Jacques Mercier, Renato Pasquali, Corinne Lautier, Saša Missoni, Dorina Ylli, Agron Ylli, Akila Zenati, Davide Lauro, Jean-Paul Cristol, Eric Renard, Agathocles Tsatsoulis, Monica Livia Gheorghiu, Giorgio Sesti, Sonia Abdelhak, Vincenzo Trischitta, Madalina Vintila, Yildiz Tutuncu, Ilhan Satman, Patrick Poucheret, Sabrina Prudente, Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université Montpellier 2 - Sciences et Techniques (UM2)-École pratique des hautes études (EPHE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut de Recherche pour le Développement (IRD), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de biologie moléculaire eucaryote (LBME), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Démarche intégrée pour l'obtention d'aliments de qualité (UMR Qualisud), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Université de La Réunion (UR)-Université de Montpellier (UM)-Avignon Université (AU)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Montpellier 1 (UM1), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Département de biochimie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Diabetes and Obesity Laboratory, Endocrinology and Nutrition Unit-Hospital Clinic, Institute of Biochemistry and Genetics of Ufa Scientific Centre, Russian Academy of Sciences [Moscow] (RAS), Division of Endocrinology, Alma Mater Studiorum University of Bologna (UNIBO), Laboratoire de Génomique Biomédicale et Oncogénétique - Biomedical Genomics and Oncogenetics Laboratory (LR11IPT05), Université Tunis El Manar (UTM)-Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut Pasteur du Maroc, Réseau International des Instituts Pasteur (RIIP), Laboratoire de Biochimie Génétique, CHU de Bab El Oued-Université d'Alger 1, Intactile Design, Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université de Tunis El Manar (UTM)-Institut Pasteur de Tunis, Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Montpellier (UM)-Université Montpellier 1 (UM1), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université Tunis El Manar (UTM), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), and Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Male, European People, obesity, Heredity, Physiology, [SDV]Life Sciences [q-bio], Gene Expression, Biochemistry, Settore MED/13 - Endocrinologia, 0302 clinical medicine, Endocrinology, Cell Signaling, Medicine and Health Sciences, Insulin, Ethnicities, ComputingMilieux_MISCELLANEOUS, 61 - Medicina, Regulator gene, 2. Zero hunger, Genetics, Metabolic Syndrome, Multidisciplinary, Aminoacids, human diet, metabolism, Middle Aged, Genetic Mapping, Romanian People, Physiological Parameters, Regulatory sequence, Medicine, Obesitat, Female, Genomic Signal Processing, Research Article, Signal Transduction, Adult, Protein Kinase C-alpha, Haploview, Science, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, Nerve Tissue Proteins, Biology, Research and Analysis Methods, Polymorphism, Single Nucleotide, 03 medical and health sciences, Insulin resistance, Gene mapping, medicine, Humans, Gene Regulation, Molecular Biology Techniques, Gene, Molecular Biology, Diabetic Endocrinology, Insulinoresistència, Endocrine Physiology, Haplotype, Gene Mapping, Body Weight, Biology and Life Sciences, Cell Biology, medicine.disease, Hormones, 030104 developmental biology, Amino Acid Transport Systems, Neutral, Haplotypes, People and Places, Population Groupings, Insulin Resistance, Amino Acids, Branched-Chain
Abstract

International audience; Branched chain amino acids (BCAA) are essential elements of the human diet, which display increased plasma levels in obesity and regained particular interest as potential biomarkers for development of diabetes. To define determinants of insulin resistance (IR) we investigated 73 genes involved in BCAA metabolism or regulation by fine-scale haplotype mapping in two European populations with metabolic syndrome. French and Romanians (n = 465) were genotyped for SNPs (Affymetrix) and enriched by imputation (BEAGLE 4.1) at 1000 genome project density. Initial association hits detected by sliding window were refined (HAPLOVIEW 3.1 and PHASE 2.1) and correlated to homeostasis model assessment (HOMAIR) index, in vivo insulin sensitivity (SI) and BCAA plasma levels (ANOVA). Four genomic regions were associated with IR located downstream of MUT, AACS, SLC6A15 and PRKCA genes (P between 9.3 and 3.7 x 10-5). Inferred haplotypes up to 13 SNPs length were associated with IR (e.g. MUT gene with P < 4.9 x 10-5; Bonferroni 1.3 x 10-3) and synergistic to HOMAIR. SNPs in the same regions were also associated with one order of magnitude lower P values (e.g. rs20167284 in the MUT gene with P < 1.27 x 10-4) and replicated in Mediterranean samples (n = 832). In French, influential haplotypes (OR > 2.0) were correlated with in vivo insulin sensitivity (1/SI) except for SLC6A15 gene. Association of these genes with BCAA levels was variable, but influential haplotypes confirmed implication of MUT from BCAA metabolism as well as a role of regulatory genes (AACS and PRKCA) and suggested potential changes in transcriptional activity. These data drive attention towards new regulatory regions involved in IR in relation with BCAA and show the ability of haplotypes in phased DNA to detect signals complimentary to SNPs, which may be useful in designing genetic markers for clinical applications in ethnic populations.

Published
2019
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2. Being in the Sky: Framing Tangible and Embodied Interaction for Future Airliner Cockpits

Author

Stéphanie Rey, Jean-Luc Vinot, Caroline Boussiron, Catherine Letondal, Valentin Becquet, Sylvain Pauchet, Claire Lavenir, Ecole Nationale de l'Aviation Civile (ENAC), Ingenuity I/O, Ingenuity, Berger-Levrault, Intactile Design, AAP AIRTIUS, ANR-15-CE23-0020, ANR, and ANR-15-CE23-0020,AIRTIUS,Etude, design et implémentation expérimentale d'un espace tangible pour les interactions pilotes-système dans le cockpit du futur(2015)

Subjects
Externalization, Computer science, media_common.quotation_subject, 05 social sciences, design, 020207 software engineering, 02 engineering and technology, ethnography, Cockpit, tangible interaction, Framing (social sciences), time-based interaction, aeronautics, ACM: D.: Software/D.2: SOFTWARE ENGINEERING/D.2.2: Design Tools and Techniques/D.2.2.12: User interfaces, Embodied cognition, Human–computer interaction, Perception, 0202 electrical engineering, electronic engineering, information engineering, phenomenology, 0501 psychology and cognitive sciences, [INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC], physical skills, 050107 human factors, media_common
Abstract

International audience; In order to contribute to a design for future airline cockpits that can address the limitations of touch-based interfaces, we analyze tangible dimensions of cockpit activity based on observations and pilot interviews. Working from these data, using TEI theory and concepts of phenomenology, we discuss the implications for tangible design of our findings. We found that the status of sensation in perception, the required level of control in actions, the safety issues using physical objects and the restricted mode of externalization, raise challenges for tangible design. Accordingly, we discuss key concepts for the design of the future cockpit, such as the use of a protected space where interaction may involve compressed externalization, rhythmic structures and customized context-aware adaptations. • Human-centered computing~Human computer interaction (HCI) • Human-centered computing~HCI design and evaluation methods • Human-centered computing~Field studies

Published
2018
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3. Document et Annotation : le cas des cartographies d’informations

Author

Desfriches Doria, Orélie, Lavenir, Claire, Equipe de recherche de Lyon en sciences de l'information et de la communication (ELICO), Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon-Université de Lyon-École nationale supérieure des sciences de l'information et des bibliothèques (ENSSIB), Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université Lumière - Lyon 2 (UL2), Dispositifs d'Information et de Communication à l'Ère du Numérique - Paris Île-de-France (DICEN-IDF), Université Paris Nanterre (UPN)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris-Est Marne-la-Vallée (UPEM), Intactile Design, ENSSIB, Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris Nanterre (UPN)-Université Paris-Est Marne-la-Vallée (UPEM), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Université Paris Nanterre (UPN)-Université Paris-Est Marne-la-Vallée (UPEM), Université Lumière - Lyon 2 (UL2)-École nationale supérieure des sciences de l'information et des bibliothèques (ENSSIB), Université de Lyon-Université de Lyon-Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon, Université Paris Nanterre (UPN)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris-Est Marne-la-Vallée (UPEM)

Subjects
[SHS.INFO]Humanities and Social Sciences/Library and information sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

4. A Semantic Modeling of Moving Objects Data to Detect the Remarkable Behavior

Author

Soltan Mohammadi, Mojdeh, Mougenot, Isabelle, Libourel Rouge, Thérèse, Christophe, Fagot, UMR 228 Espace-Dev, Espace pour le développement, Université de Guyane (UG)-Université des Antilles (UA)-Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM), Intactile Design, Bourse CIFRE, and Wageningen University, Chair group GIS & Remote Sensing (WUR-GRS)

Subjects
spatio-temporal data, trajectory model, moving object, ontology, ComputingMilieux_MISCELLANEOUS, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract

International audience

Published
2017

5. Modèle sémantique de trajectoire d’objet mobile

Author

Soltan Mohammadi, Mojdeh, Libourel Rouge, Thérèse, Mougenot, Isabelle, Christophe, Fagot, UMR 228 Espace-Dev, Espace pour le développement, Université de Guyane (UG)-Université des Antilles (UA)-Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM), and Intactile Design

Subjects
[INFO.INFO-WB]Computer Science [cs]/Web, [INFO.INFO-LO]Computer Science [cs]/Logic in Computer Science [cs.LO], ComputingMilieux_MISCELLANEOUS, [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]
Abstract

International audience

Published
2016

6. Socio-cultural modeling and dynamic decision making

Author

Christophe Fagot, Orélie Desfriches Doria, Peter Svenmarck, Equipe de recherche de Lyon en sciences de l'information et de la communication (ELICO), Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon-Université de Lyon-École nationale supérieure des sciences de l'information et des bibliothèques (ENSSIB), Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université Lumière - Lyon 2 (UL2), Dispositifs d'Information et de Communication à l'Ère du Numérique - Paris Île-de-France (DICEN-IDF), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Université Paris Nanterre (UPN)-Université Paris-Est Marne-la-Vallée (UPEM), Intactile Design, Swedish Defence Research Agency (FOI), (FOI), S. Schatz and M. Hoffman (Eds), Université Lumière - Lyon 2 (UL2)-École nationale supérieure des sciences de l'information et des bibliothèques (ENSSIB), Université de Lyon-Université de Lyon-Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon, Université Paris Nanterre (UPN)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris-Est Marne-la-Vallée (UPEM), and Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris Nanterre (UPN)-Université Paris-Est Marne-la-Vallée (UPEM)

Subjects
Interface (Java), Computer science, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, 05 social sciences, Frame (networking), 020206 networking & telecommunications, 02 engineering and technology, Field (computer science), Visualization, Human–computer interaction, 0502 economics and business, 0202 electrical engineering, electronic engineering, information engineering, Use case, Decision-making, Dynamic decision-making, Interactive visualization, 050203 business & management, ComputingMilieux_MISCELLANEOUS
Abstract

In the field of Cross-Cultural Decision Making, our work is oriented towards supporting decision making process by providing a dynamic and interactive visualisation interface. The idea with this approach is that users should be able to explore a problem space using visualisation that facilitate quick perceptions and understanding. Vesta-Cosy application, developed in the frame of a research project, therefore combines paraconsistent reasoning and works on graphic semiology. We first present the currently used approaches of decision making in Vesta Cosy. Thereafter, the Vesta Cosy application is described in details, especially the different models and their connection with visual and algorithmic units. We also present the theoretical framework which we use for a specific use case scenario. This theoretical framework aims at enabling the consideration of socio-cultural factors in Decision Making.

Published
2016
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7. Des cartographies sémantiques à la prise de décision

Author

Desfriches Doria, Orélie, Christophe, Fagot, Lavenir, Claire, Equipe de recherche de Lyon en sciences de l'information et de la communication (ELICO), Université Lumière - Lyon 2 (UL2)-École nationale supérieure des sciences de l'information et des bibliothèques (ENSSIB), Université de Lyon-Université de Lyon-Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Dispositifs d'Information et de Communication à l'Ère du Numérique - Paris Île-de-France (DICEN-IDF), Université Paris Nanterre (UPN)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris-Est Marne-la-Vallée (UPEM), Intactile Design, Vesta-Cosy (RAPID DGA), Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon-Université de Lyon-École nationale supérieure des sciences de l'information et des bibliothèques (ENSSIB), Université de Lyon-Université Lumière - Lyon 2 (UL2), Université Paris Nanterre (UPN)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris-Est Marne-la-Vallée (UPEM), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris Nanterre (UPN)-Université Paris-Est Marne-la-Vallée (UPEM), Conservatoire National des Arts et Métiers [CNAM] (CNAM), and HESAM Université (HESAM)-HESAM Université (HESAM)-Université Paris Nanterre (UPN)-Université Paris-Est Marne-la-Vallée (UPEM)

Subjects
DECISION MAKING, EXPERT-KNOWLEDGE SYSTEMS, DATAVISUALISATION, [SHS.INFO]Humanities and Social Sciences/Library and information sciences, MODELS, CARTOGRAPHY, COMPUTER APPLICATION, [SHS]Humanities and Social Sciences, MODELES, COLLABORATIF, INTERACTIONS-UTILISATEUR, DATAVIZUALIZATION, SYMBOLIC REPRESENTATION, ARGUMENTATION, APPLICATION INFORMATIQUE, PRISE DE DECISION, USER-INTERACTION, SYSTEME-EXPERT, COLLABORATIVE, REPRESENTATION SYMBOLIQUE, CARTOGRAPHIE
Abstract

International audience; As part of the research project Vesta-Cosy, we develop methodological and conceptual principles for a computer application for information mapping for visualizing and analyzing complex situations based on knowledge models. Our proposals are connected to theoretical fields, especially complex system engineering and expert-system engineering. We discuss decision making approaches that guide the development of tool and views about argumentation that allow us to design arguments visualization capabilities. Then we present Vesta Cosy application in details, especially the different models and their connection with visual and algorithmic units. Finally, a use case scenario is introduced, we report some of the actual problems, and adress some guidelines for an assessment protocol.; Dans le cadre du projet de recherche Vesta-Cosy (Vers un ESpace Tactile d’Argumentation, COllaboratif et Symbolique), nous développons des principes méthodologiques, conceptuels et une application informatique de cartographie symbolique permettant de visualiser et d’analyser des situations complexes en s’appuyant sur des modèles de connaissances métier. Nous présentons des propositions en lien avec les champs disciplinaires qui inspirent ce projet, notamment l’ingénierie des systèmes complexes et l’ingénierie des systèmes-experts. Nous évoquons les approches de la prise de décision qui guident le développement de l’outil et les approches de l’argumentation qui nous permettent de concevoir des fonctionnalités de visualisation d’argumentaires. L’application Vesta Cosy est présentée de manière détaillée, notamment concernant les différents modèles et leur articulation avec des modules visuels et algorithmiques. Enfin, nous évoquons un scénario d’usage, les problématiques en cours, ainsi que des orientations pour un futur protocole d’évaluation.

Published
2016
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8. Visualisation d’information à base de modèles pour l’argumentation

Author

Desfriches Doria, Orélie, Lavenir, Claire, Christophe, Fagot, Equipe de recherche de Lyon en sciences de l'information et de la communication (ELICO), Université Lumière - Lyon 2 (UL2)-École nationale supérieure des sciences de l'information et des bibliothèques (ENSSIB), Université de Lyon-Université de Lyon-Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Dispositifs d'Information et de Communication à l'Ère du Numérique - Paris Île-de-France (DICEN-IDF), Université Paris Nanterre (UPN)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Paris-Est Marne-la-Vallée (UPEM), Intactile Design, Vesta-Cosy (RAPID DGA), Université Paris Nanterre (UPN)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris-Est Marne-la-Vallée (UPEM), Sciences Po Lyon - Institut d'études politiques de Lyon (IEP Lyon), Université de Lyon-Université de Lyon-École nationale supérieure des sciences de l'information et des bibliothèques (ENSSIB), Université de Lyon-Université Lumière - Lyon 2 (UL2), Conservatoire National des Arts et Métiers [CNAM] (CNAM), and HESAM Université (HESAM)-HESAM Université (HESAM)-Université Paris Nanterre (UPN)-Université Paris-Est Marne-la-Vallée (UPEM)

Subjects
[SHS.INFO]Humanities and Social Sciences/Library and information sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015

9. Supporting air traffic control collaboration with a tabletop system

Author

Carole Dupré, Hélène Gaspard-Boulinc, Stephane Vales, Stéphane Conversy, Stéphane Chatty, Claire Ollagnon, ENAC - Equipe Informatique Interactive (LII), Ecole Nationale de l'Aviation Civile (ENAC), Interactive Critical Systems (IRIT-ICS), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Intuilab, and Intactile Design

Subjects
tabletop, Computer science, business.industry, 05 social sciences, Multi-touch, 020207 software engineering, 02 engineering and technology, Air traffic control, Multi-user, USable, collaboration, air traffic control, Task (project management), Software, Human–computer interaction, Computer-supported cooperative work, 0202 electrical engineering, electronic engineering, information engineering, 0501 psychology and cognitive sciences, [INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC], Set (psychology), business, CSCW, 050107 human factors
Abstract

International audience; Collaboration is key to safety and efficiency in Air Traffic Control. Legacy paper-based systems enable seamless and non-verbal collaboration, but trends in new software and hardware for ATC tend to separate controllers more and more, which hinders collaboration. This paper presents a new interactive system designed to support collaboration in ATC. We ran a series of interviews and workshops to identify collaborative situations in ATC. From this analysis, we derived a set of requirements to support collaboration: support mutual awareness, communication and coordination, dynamic task allocation and simultaneous use with more than two people. We designed a set of new interactive tools to fulfill the requirements, by using a multi-user tabletop surface, appropriate feedthrough, and reified and partially-accomplishable actions. Preliminary evaluation shows that feedthrough is important, users benefit from a number of tools to communicate and coordinate their actions, and the tabletop is actually usable by three people both in tightly coupled tasks and parallel, individual activities. At a higher level, we also found that co-location is not enough to generate mutual awareness if users are not engaged in meaningful collaboration.

Published
2011
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10. MAMMI Phase 3 - Exploring collaborative workspaces for air traffic controllers in the scope of SESAR

Author

Valès, Stéphane, Dupré, Carole, Gaspard-Boulinc, Hélène, Conversy, Stéphane, Ollagnon, Claire, Peyruquéou, Vincent, Viala, Joel, Porte, Laurence, Intuilab, ENAC - Equipe Informatique Interactive (LII), Ecole Nationale de l'Aviation Civile (ENAC), and Intactile Design

Subjects
[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC], [INFO.INFO-HC] Computer Science [cs]/Human-Computer Interaction [cs.HC]
Abstract

International audience; The MAMMI (Multi Actors Man Machine Interfaces) project explores new ways for the Air Traffic Controllers (ATCOs) to take advantage of collaborative environments to support their activity. It relies on the following principles: 1. Several ATCOs interacting collaboratively to control wide airspaces 2. Real-time tasks sharing and workload repartition 3. Lesser specialization of the ATCOs The current phase of the MAMMI project focuses on the exploration of the possible collaborative activities in the scope of SESAR. As the operational practices and ATC concepts in SESAR are still evolving a lot, this work is based on assumptions presented below and does not provide experimental validation yet. This paper presents the core issues regarding collaboration that have been identified in SESAR, based on previous work in MAMMI. It then exposes a series of concrete ATC scenarios in the SESAR context showing the stakes and possible directions in defining collaborative practices for future ATCOs. Finally, this paper presents possible solutions to provide collaborative workspaces supporting the different activities of the ATCOs, as exposed in the ATC scenarios.

Published
2008

11. MAMMI Phase2 - Design and evaluation test bed for collaborative practices on en-route control positions

Author

Valès, Stéphane, Conversy, Stéphane, Lard, Jérome, Ollagnon, Claire, Intuilab, ENAC - Equipe Informatique Interactive (LII), Ecole Nationale de l'Aviation Civile (ENAC), Thales Research and Technology [Palaiseau], THALES, and Intactile Design

Subjects
mutual activity awareness, multi-touch and multi-user interaction, tasks and workload sharing, tactic planner dynamic organization, [INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC], collaboration models for Air Traffic Controllers
Abstract

International audience; The MAMMI project studies ways to improve the collaboration between ATCOs on the same position, using modern ATC concepts and tools, and explores new opportunities for dynamic organizations and workload management. This paper presents the problems considered by MAMMI and the design and evaluation test-bed that will help progressively introducing and evaluating new solutions, with the overall objective to get relevant operational feedback.

Published
2007

12. Les transitions visuelles différenciées : principes et applications

Author

Céline Schlienger, Pierre Dragicevic, Claire Ollagnon, Stéphane Chatty, Intuilab, and Intactile Design

Subjects
conscience de la situation, Situation awareness, Computer science, Transition (fiction), animation, 05 social sciences, 020207 software engineering, 02 engineering and technology, Animation, situation awareness, Computer graphics (images), 0202 electrical engineering, electronic engineering, information engineering, transitions animées, cartoon, 0501 psychology and cognitive sciences, [INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC], Differential (infinitesimal), Graphics, dessin animé, 050107 human factors, Computer animation, animated transitions
Abstract

International audience; Pour servir de support à la conception d'animations dans les interfaces graphiques, nous introduisons et nous définissons le concept de transition visuelle. Nous utilisons ensuite ce modèle descriptif pour introduire une nouvelle technique d'animation : les transitions visuelles différenciées, qui permettent de véhiculer de l'information en jouant sur les transitions visuelles. Cette technique est illustrée sur des cas concrets avec le concours d'une animatrice professionnelle. Nous énonçons également des propriétés caractérisant les transitions visuelles différenciées, et abordons les principales questions relatives à leur conception.

Published
2006
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13. Fine-scale haplotype mapping of MUT, AACS, SLC6A15 and PRKCA genes indicates association with insulin resistance of metabolic syndrome and relationship with branched chain amino acid metabolism or regulation.

Author

Haydar S, Grigorescu F, Vintilă M, Cogne Y, Lautier C, Tutuncu Y, Brun JF, Robine JM, Pugeat M, Normand C, Poucheret P, Gheorghiu ML, Georgescu C, Badiu C, Băculescu N, Renard E, Ylli D, Badiou S, Sutra T, Cristol JP, Mercier J, Gomis R, Macias JM, Litvinov S, Khusnutdinova E, Poiana C, Pasquali R, Lauro D, Sesti G, Prudente S, Trischitta V, Tsatsoulis A, Abdelhak S, Barakat A, Zenati A, Ylli A, Satman I, Kanninen T, Rinato Y, and Missoni S

Subjects
Adult, Amino Acids, Branched-Chain metabolism, Female, Humans, Male, Metabolic Syndrome blood, Middle Aged, Amino Acid Transport Systems, Neutral genetics, Amino Acids, Branched-Chain genetics, Haplotypes, Insulin Resistance genetics, Metabolic Syndrome genetics, Nerve Tissue Proteins genetics, Polymorphism, Single Nucleotide, Protein Kinase C-alpha genetics
Abstract

Branched chain amino acids (BCAA) are essential elements of the human diet, which display increased plasma levels in obesity and regained particular interest as potential biomarkers for development of diabetes. To define determinants of insulin resistance (IR) we investigated 73 genes involved in BCAA metabolism or regulation by fine-scale haplotype mapping in two European populations with metabolic syndrome. French and Romanians (n = 465) were genotyped for SNPs (Affymetrix) and enriched by imputation (BEAGLE 4.1) at 1000 genome project density. Initial association hits detected by sliding window were refined (HAPLOVIEW 3.1 and PHASE 2.1) and correlated to homeostasis model assessment (HOMAIR) index, in vivo insulin sensitivity (SI) and BCAA plasma levels (ANOVA). Four genomic regions were associated with IR located downstream of MUT, AACS, SLC6A15 and PRKCA genes (P between 9.3 and 3.7 x 10-5). Inferred haplotypes up to 13 SNPs length were associated with IR (e.g. MUT gene with P < 4.9 x 10-5; Bonferroni 1.3 x 10-3) and synergistic to HOMAIR. SNPs in the same regions were also associated with one order of magnitude lower P values (e.g. rs20167284 in the MUT gene with P < 1.27 x 10-4) and replicated in Mediterranean samples (n = 832). In French, influential haplotypes (OR > 2.0) were correlated with in vivo insulin sensitivity (1/SI) except for SLC6A15 gene. Association of these genes with BCAA levels was variable, but influential haplotypes confirmed implication of MUT from BCAA metabolism as well as a role of regulatory genes (AACS and PRKCA) and suggested potential changes in transcriptional activity. These data drive attention towards new regulatory regions involved in IR in relation with BCAA and show the ability of haplotypes in phased DNA to detect signals complimentary to SNPs, which may be useful in designing genetic markers for clinical applications in ethnic populations., Competing Interests: The authors have declared that no competing interests exist. We confirm that commercial affiliation of BC Platforms Ltd Oy, Espoo, Finland and Intactile Design SA, Montpellier, France does not alter our adherence to PLOS ONE policies on sharing data and materials.

Published
2019
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14. Branched-Chain Amino Acid Database Integrated in MEDIPAD Software as a Tool for Nutritional Investigation of Mediterranean Populations.

Author

Haydar S, Paillot T, Fagot C, Cogne Y, Fountas A, Tutuncu Y, Vintila M, Tsatsoulis A, Thanh Chi P, Garandeau P, Chetea D, Badiu C, Gheorghiu M, Ylli D, Lautier C, Jarec M, Monnier L, Normand C, Šarac J, Barakat A, Missoni S, Pugeat M, Poucheret P, Hanzu F, Gomis R, Macias JM, Litvinov S, Khusnutdinova E, Poiana C, Pasquali R, Lauro D, Sesti G, Trischitta V, Abdelhak S, Zenati A, Ylli A, Satman I, Kanninen T, Rinato Y, and Grigorescu F

Subjects
Adult, Aged, Female, France, Greece, Humans, Male, Mediterranean Region, Middle Aged, Nutrition Surveys, Amino Acids, Branched-Chain analysis, Databases, Factual statistics & numerical data, Food Analysis methods, Nutrition Assessment, Software
Abstract

Branched-chained amino acids (BCAA) are essential dietary components for humans and can act as potential biomarkers for diabetes development. To efficiently estimate dietary intake, we developed a BCAA database for 1331 food items found in the French Centre d'Information sur la Qualité des Aliments (CIQUAL) food table by compiling BCAA content from international tables, published measurements, or by food similarity as well as by calculating 267 items from Greek, Turkish, Romanian, and Moroccan mixed dishes. The database embedded in MEDIPAD software capable of registering 24 h of dietary recalls (24HDR) with clinical and genetic data was evaluated based on archived 24HDR of the Saint Pierre Institute (France) from 2957 subjects, which indicated a BCAA content up to 4.2 g/100 g of food and differences among normal weight and obese subjects across BCAA quartiles. We also evaluated the database of 119 interviews of Romanians, Turkish and Albanians in Greece (27⁻65 years) during the MEDIGENE program, which indicated mean BCAA intake of 13.84 and 12.91 g/day in males and females, respectively, comparable to other studies. The MEDIPAD is user-friendly, multilingual, and secure software and with the BCAA database is suitable for conducting nutritional assessment in the Mediterranean area with particular facilities for food administration., Competing Interests: The authors declare no conflict of interest.

Published
2018
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