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Objective: To compare the cost-utility of specialized multidisciplinary care (MC) and standard care (SC) of patients with reduced ejection fraction heart failure (HFrEF). Materials and Methods: The present study was a retrospective analytical cohort study on societal perspective in the 12-month follow-up of patients in the tertiary hospitals in Thailand. Conventional care was offered to the patients in the SC group by the hospitals, and the MC group received additional care in the specialized care of the multidisciplinary heart failure clinic. The authors collected data pertaining to resource utilization from the hospital medical records. The unit cost was based on the Thai Health Technology Assessment's standard cost list. Quality-adjusted life years (QALYs) were the health outcome of the study. Results: The total cost per patient in MC group was $835.24 versus $933.10 in the SC group. SC and MC QALYs were 0.72 and 0.78, respectively. MC is an outstanding alternative to save cost of $97.86 annually per patient. Patients in the MC group used fewer resources because the complication and hospitalization rates were lower. Conclusion: MC appeared to be a cost-saving approach compared with ambulatory care delivery from SC to patients with HFrEF. [ABSTRACT FROM AUTHOR]