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The current study aimed to evaluate the anti-arthritic effects of a nanocomposite from Cinnamomum zeylanicum, and to further demonstrate its mechanism of action in RA induced RA by Complete Freund's Adjuvant (CFA). and it was diagnosed by atomic force microscopy (AFM) and infrared spectroscopy (FT-IR) revealed the emergence of new diffraction levels for nanocomposites, which clearly indicates the success of the loading process. X-ray evaluation clearly showed the severity of joint deformity according to the extent of osteoarthritis, joint spaces, soft tissue inflammation, subchondral erosion, and articular sclerosis. The immunological results indicated that the induction of rheumatoid arthritis (RF) in male G2 white rats led to a significant (P

The current study aimed to know the protective effect of the aqueous extract of Cinnamon zeylanicum and the free Cinnamon nanocomplex loaded with MTX treatment to reduce the effect of arthritis induced with Complete Freunds (CFA Adjuvant) in male albino rats by studying some changes in immunological and histological parameters. Atomic force microscope (AFM) revealed the appearance of changes in the surface of nanocomposites loaded with treatment. The immunological results indicated that the induction of rheumatoid arthritis (RF) in male white G2 rats led to a significant increase (P