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1. Classifications of moderate to severe asthma phenotypes in Japan and analysis of serum biomarkers: A Nationwide Cohort Study in Japan (NHOM Asthma Study)

Author

Suzukawa, Maho, Ohta, Ken, Fukutomi, Yuma, Hashimoto, Hiroya, Endo, Takeo, Abe, Masahiro, Kamide, Yosuke, Yoshida, Makoto, Kikuchi, Yoshihiro, Kita, Toshiyuki, Chibana, Kenji, Tanimoto, Yasushi, Hyodo, Kentaro, Takata, Shohei, Inui, Toshiya, Yasui, Masahide, Harada, Yoshinori, Sato, Toshio, Sakakibara, Yumi, Minakata, Yoshiaki, Inoue, Yoshikazu, Tamaki, Shinji, Shinohara, Tsutomu, Takami, Kazutaka, Tsubakihara, Motofumi, Oki, Masahide, Wakamatsu, Kentaro, Horiba, Masahide, Ideura, Gen, Hidaka, Koko, Saito, Akiko M., Kobayashi, Nobuyuki, and Taniguchi, Masami

Published
2023
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3. Effect of Mirtazapine for the Prevention of Nausea and Vomiting in Patients With Thoracic Cancer Receiving Platinum-based Chemotherapy

Author

KINOMURA, MOTOHIKO, primary, IIHARA, HIROTOSHI, additional, FUJII, HIRONORI, additional, HIROSE, CHIEMI, additional, ENDO, JUNKI, additional, YANASE, KOMEI, additional, INUI, TOSHIYA, additional, KAITO, DAIZO, additional, SASAKI, YUKA, additional, GOMYO, TAKENOBU, additional, SAKAI-MASUDA, CHIZURU, additional, KAWAE, DAISUKE, additional, KITAMURA, YU, additional, FUKUI, MASACHIKA, additional, KOBAYASHI, RYO, additional, OHNO, YASUSHI, additional, and SUZUKI, AKIO, additional

Published
2023
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7. Soluble ST2 enhances IL ‐33–induced neutrophilic and pro‐type 2 inflammation in the lungs

Author

Watanabe, Masato, primary, Nakamoto, Keitaro, additional, Inui, Toshiya, additional, Sada, Mitsuru, additional, Chibana, Kazuyuki, additional, Miyaoka, Chika, additional, Yoshida, Yuki, additional, Aso, Jumpei, additional, Nunokawa, Hiroki, additional, Honda, Kojiro, additional, Nakamura, Masuo, additional, Tamura, Masaki, additional, Hirata, Aya, additional, Oda, Miku, additional, Takata, Saori, additional, Saraya, Takeshi, additional, Kurai, Daisuke, additional, Ishii, Haruyuki, additional, and Takizawa, Hajime, additional

Published
2022
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9. Cancer cachexia as a determinant of efficacy of first‑line pembrolizumab in patients with advanced non‑small cell lung cancer

Author

Fujii, Hironori, primary, Araki, Ayumu, additional, Iihara, Hirotoshi, additional, Kaito, Daizo, additional, Hirose, Chiemi, additional, Kinomura, Motohiko, additional, Yamazaki, Mizuki, additional, Endo, Junki, additional, Inui, Toshiya, additional, Yanase, Komei, additional, Sasaki, Yuka, additional, Gomyo, Takenobu, additional, Sakai, Chizuru, additional, Kawae, Daisuke, additional, Kitamura, Yu, additional, Fukui, Masachika, additional, Kobayashi, Ryo, additional, Ohno, Yasushi, additional, and Suzuki, Akio, additional

Published
2022
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11. Ruxolitinib inhibits poly(I:C) and type 2 cytokines‐induced CCL5 production in bronchial epithelial cells: A potential therapeutic agent for severe eosinophilic asthma

Author

Sada, Mitsuru, primary, Watanabe, Masato, additional, Inui, Toshiya, additional, Nakamoto, Keitaro, additional, Hirata, Aya, additional, Nakamura, Masuo, additional, Honda, Kojiro, additional, Saraya, Takeshi, additional, Kurai, Daisuke, additional, Kimura, Hirokazu, additional, Ishii, Haruyuki, additional, and Takizawa, Hajime, additional

Published
2021
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14. Ruxolitinib inhibits poly (I:C) and IL-13-induced CCL5 production in bronchial epithelial cells: A potential therapeutic agent for severe eosinophilic asthma.

Author

Sada, Mitsuru, primary, Watanabe, Masato, additional, Nakamoto, Keitaro, additional, Inui, Toshiya, additional, Hirata, Aya, additional, Nakamura, Masuo, additional, Honda, Kojiro, additional, Saraya, Takeshi, additional, Kurai, Daisuke, additional, Kimura, Hirokazu, additional, Ishii, Haruyuki, additional, and Takizawa, Hajime, additional

Published
2020
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17. Additional file 1: of Serum sST2 levels predict severe exacerbation of asthma

Author

Watanabe, Masato, Keitaro Nakamoto, Inui, Toshiya, Sada, Mitsuru, Honda, Kojiro, Tamura, Masaki, Ogawa, Yukari, Yokoyama, Takuma, Saraya, Takeshi, Kurai, Daisuke, Haruyuki Ishii, and Takizawa, Hajime

Abstract

Table S1. The exacerbation scores and their predictive values for worsening asthma. Figure S1. Relationship between oral corticosteroid usage and biomarkers. (DOCX 387 kb)

Published
2018
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18. Bronchial epithelial cells produce CXCL1 in response to LPS and TNFα: A potential role in the pathogenesis of COPD

Author

Inui, Toshiya, primary, Watanabe, Masato, additional, Nakamoto, Keitaro, additional, Sada, Mitsuru, additional, Hirata, Aya, additional, Nakamura, Masuo, additional, Honda, Kojiro, additional, Ogawa, Yukari, additional, Takata, Saori, additional, Yokoyama, Takuma, additional, Saraya, Takeshi, additional, Kurai, Daisuke, additional, Wada, Hiroo, additional, Ishii, Haruyuki, additional, and Takizawa, Hajime, additional

Published
2018
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20. Serum Reactive Oxygen Metabolite Levels Predict Severe Exacerbations of Asthma

Author

Nakamoto, Keitaro, primary, Watanabe, Masato, additional, Sada, Mitsuru, additional, Inui, Toshiya, additional, Nakamura, Masuo, additional, Honda, Kojiro, additional, Wada, Hiroo, additional, Mikami, Yu, additional, Matsuzaki, Hirotaka, additional, Horie, Masafumi, additional, Noguchi, Satoshi, additional, Yamauchi, Yasuhiro, additional, Koyama, Hikari, additional, Kogane, Toshiyuki, additional, Kohyama, Tadashi, additional, and Takizawa, Hajime, additional

Published
2016
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21. Reactive oxygen metabolite levels are surrogate biomarkers for predicting exacerbation of bronchial asthma

Author

Nakamoto, Keitaro, primary, Watanabe, Masato, additional, Sada, Mitsuru, additional, Inui, Toshiya, additional, Ogawa, Yukari, additional, Nakamura, Masuo, additional, Honda, Kojiro, additional, Koide, Takashi, additional, Takata, Saori, additional, Yokoyama, Takuma, additional, Saraya, Takeshi, additional, Kurai, Daisuke, additional, Wada, Hiroo, additional, Ishii, Haruyuki, additional, and Takizawa, Hajime, additional

Published
2016
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23. Regulation of GROα production in human bronchial epithelial cells

Author

Inui, Toshiya, primary, Watanabe, Masato, additional, Nakamoto, Keitaro, additional, Sada, Mitsuru, additional, Tsuji, Shingo, additional, Hirata, Aya, additional, Nakamura, Masuo, additional, Ogawa, Yukari, additional, Koide, Takashi, additional, Takata, Saori, additional, Yokoyama, Takuma, additional, Kurai, Daisuke, additional, Saraya, Takeshi, additional, Ishii, Haruyuki, additional, Wada, Hiroo, additional, and Takizawa, Hajime, additional

Published
2016
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24. Calcium oxalate crystal deposition in a patient with Aspergilloma due to Aspergillus niger

Author

Oda, Miku, Saraya, Takeshi, Wakayama, Megumi, Shibuya, Kazutoshi, Ogawa, Yukari, Inui, Toshiya, Yokoyama, Emi, Inoue, Manami, Shimoyamada, Hiroaki, Fujiwara, Masachika, Ota, Tomohiro, Takizawa, Hajime, and Goto, Hajime

Subjects
fungi, Case Report, skin and connective tissue diseases, respiratory tract diseases
Abstract

Discrimination between aspergilloma and chronic necrotizing pulmonary aspergillosis (CNPA) based on radiological findings can difficult. We describe a patient with aspergilloma and organizing pneumonia that was possibly caused by Aspergillus niger infection and radiologically mimicked CNPA. A postmortem histological analysis showed diffuse alveolar damage that had originated in peri-cavitary lung parenchyma. Calcium oxalate or Aspergillus niger was located inside, but not outside the cavity in the right upper lobe. Calcium oxalate or other unknown hyphal bioactive components might provoke severe lung inflammation not only adjacent to the cavity, but also on the contralateral side.

Published
2013

25. IL-17A synergistically stimulates TNF-α-induced IL-8 production in human airway epithelial cells: A potential role in amplifying airway inflammation

Author

Honda, Kojiro, primary, Wada, Hiroo, additional, Nakamura, Masuo, additional, Nakamoto, Keitaro, additional, Inui, Toshiya, additional, Sada, Mitsuru, additional, Koide, Takashi, additional, Takata, Saori, additional, Yokoyama, Takuma, additional, Saraya, Takeshi, additional, Kurai, Daisuke, additional, Ishii, Haruyuki, additional, Goto, Hajime, additional, and Takizawa, Hajime, additional

Published
2016
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26. Oxidative stress and biomarkers in patients with bronchial asthma

Author

Nakamoto, Keitaro, primary, Wada, Hiroo, additional, Tsuji, Shingo, additional, Sada, Mitsuru, additional, Inui, Toshiya, additional, Nakamura, Masuo, additional, Honda, Kojiro, additional, Tanaka, Yasutaka, additional, Koide, Takashi, additional, Takata, Saori, additional, Watanabe, Masato, additional, Yokoyama, Takuma, additional, Saraya, Takeshi, additional, Kurai, Daisuke, additional, Ishii, Haruyuki, additional, and Takizawa, Hajime, additional

Published
2015
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27. Phenotypic characterization of asthma-COPD overlap syndrome: Comparison with asthma and COPD

Author

Inui, Toshiya, primary, Nakamoto, Keitaro, additional, Sada, Mitsuru, additional, Tsuji, Shingo, additional, Nakamura, Masuo, additional, Tanaka, Yasutaka, additional, Koide, Takashi, additional, Takata, Saori, additional, Yokoyama, Takuma, additional, Saraya, Takeshi, additional, Kurai, Daisuke, additional, Ishii, Haruyuki, additional, Wada, Hiroo, additional, and Takizawa, Hajime, additional

Published
2015
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28. A case of malignant peritoneal mesothelioma revealed with limitation of PET-CT in the diagnosis of thoracic metastasis

Author

Saraya, Takeshi, Yokoyama, Takuma, Ishii, Haruyuki, Tanaka, Yasutaka, Tsujimoto, Naoki, Ogawa, Yukari, Sohara, Erei, Nakajima, Akira, Inui, Toshiya, Sayuki, Hiraoka, Fujiwara, Masachika, Oka, Teruaki, Kawachi, Riken, Goya, Tomoyuki, Takizawa, Hajime, and Goto, Hajime

Subjects
Case Report, respiratory system, respiratory tract diseases
Abstract

A 47-year-old man was referred to our hospital because of a 2-month history of dry cough, 2-kg weight loss, and a feeling of abdominal fullness. The PET-CT scan depicts the intense standard uptake values (SUVs) of the anterior and subphrenic lymphnodes, and intraperitoneal cavity, especially in the omentum, while, no uptake was found in the pleural cavity. Based on the pathological findings of the open lung biopsy specimens, he was diagnosed with malignant peritoneal mesothelioma of epithelioid type with thoracic metastasis. The present case demonstrated the some of the limitations of PET-CT in the diagnosis of malignant mesothelioma, which failed to detect pleural involvement despite aggressive invasion by this tumor.

Published
2013

29. Soluble ST2 as a prognostic marker in community-acquired pneumonia

Author

Watanabe, Masato, primary, Takizawa, Hajime, additional, Tamura, Masaki, additional, Nakajima, Akira, additional, Kurai, Daisuke, additional, Ishii, Haruyuki, additional, Takata, Saori, additional, Nakamoto, Keitaro, additional, Sohara, Erei, additional, Honda, Koujirou, additional, Nakamura, Masuo, additional, Inui, Toshiya, additional, Wada, Hiroo, additional, and Goto, Hajime, additional

Published
2015
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31. Bronchial Schwannoma Masquerading as Cause of Hemoptysis in a Patient with Pulmonary Embolism

Author

Nagatomo, Tomoko, primary, Saraya, Takeshi, additional, Nakamura, Masuo, additional, Tanaka, Yasutaka, additional, Nakajima, Akira, additional, Yamada, Atsuko, additional, Ogawa, Yukari, additional, Tsujimoto, Naoki, additional, Sohara, Erei, additional, Inui, Toshiya, additional, Sada, Mitsuru, additional, Ishida, Manabu, additional, Oda, Miku, additional, Hirukawa, Ichiro, additional, Fujiwara, Masachika, additional, Oka, Teruaki, additional, Takei, Hidefumi, additional, Goya, Tomoyuki, additional, Takizawa, Hajime, additional, and Goto, Hajime, additional

Published
2013
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33. Classifications of moderate to severe asthma phenotypes in Japan and analysis of serum biomarkers: A Nationwide Cohort Study in Japan (NHOM Asthma Study)

Author

Suzukawa, Maho, Ohta, Ken, Fukutomi, Yuma, Hashimoto, Hiroya, Endo, Takeo, Abe, Masahiro, Kamide, Yosuke, Yoshida, Makoto, Kikuchi, Yoshihiro, Kita, Toshiyuki, Chibana, Kenji, Tanimoto, Yasushi, Hyodo, Kentaro, Takata, Shohei, Inui, Toshiya, Yasui, Masahide, Harada, Yoshinori, Sato, Toshio, Sakakibara, Yumi, Minakata, Yoshiaki, Inoue, Yoshikazu, Tamaki, Shinji, Shinohara, Tsutomu, Takami, Kazutaka, Tsubakihara, Motofumi, Oki, Masahide, Wakamatsu, Kentaro, Horiba, Masahide, Ideura, Gen, Hidaka, Koko, Saito, Akiko M., Kobayashi, Nobuyuki, and Taniguchi, Masami

Abstract

Asthma is a heterogeneous disease, and phenotyping can facilitate understanding of disease pathogenesis and direct appropriate asthma treatment. This nationwide cohort study aimed to phenotype asthma patients in Japan and identify potential biomarkers to classify the phenotypes.

Published
2022
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34. A Pilot Study of Transdermal Application of Diphenhydramine to the Nasal Ala in Patients with Allergic Rhinitis and Asthma.

Author

Kamimura M, Inui T, Mouri A, Todo H, Sugibayashi K, and Asano K

Subjects
Humans, Pilot Projects, Diphenhydramine therapeutic use, Surveys and Questionnaires, Quality of Life, Asthma drug therapy
Abstract

Background: To date, topical allergic rhinitis drugs must be applied intranasally. We studied the efficacy, safety, and impact on co-existing asthma symptoms of transdermal delivery of diphenhydramine through the nasal ala., Methods: We enrolled outpatients with symptomatic allergic rhinitis and asthma who were on stable medication for at least 4 weeks. Patients applied diphenhydramine ointment, 0.07 g measured with weighing spoon (0.7 mg diphenhydramine), to the nasal ala twice a day for 2 weeks, followed by 2 weeks' washout. Effects were assessed with the Japanese Allergic Rhinitis Standard Quality of Life Questionnaire (JRQLQ) and Self-assessment of Allergic Rhinitis and Asthma (SACRA) and Asthma Control Test (ACT) questionnaires., Results: Ten patients participated in the study. Two patients experienced acute exacerbation of asthma during the intervention phase, but no other adverse effects occurred. Self-assessments indicated efficacy in treating nasal symptoms in 5 patients. No significant changes in scores were seen, although mean total JRQLQ score showed a numerical improvement (from 34.3 [21.0] to 14.4 [8.8]; P = 0.0547). Asthma symptoms improved subjectively in 2 patients., Conclusions: The efficacy of transdermal application of diphenhydramine on the nasal ala for treating allergic rhinitis was not conclusive, but appears to be effective in certain patients.

Published
2022

35. Calcium oxalate crystal deposition in a patient with Aspergilloma due to Aspergillus niger.

Author

Oda M, Saraya T, Wakayama M, Shibuya K, Ogawa Y, Inui T, Yokoyama E, Inoue M, Shimoyamada H, Fujiwara M, Ota T, Takizawa H, and Goto H

Abstract

Discrimination between aspergilloma and chronic necrotizing pulmonary aspergillosis (CNPA) based on radiological findings can difficult. We describe a patient with aspergilloma and organizing pneumonia that was possibly caused by Aspergillus niger infection and radiologically mimicked CNPA. A postmortem histological analysis showed diffuse alveolar damage that had originated in peri-cavitary lung parenchyma. Calcium oxalate or Aspergillus niger was located inside, but not outside the cavity in the right upper lobe. Calcium oxalate or other unknown hyphal bioactive components might provoke severe lung inflammation not only adjacent to the cavity, but also on the contralateral side.

Published
2013
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36. A case of malignant peritoneal mesothelioma revealed with limitation of PET-CT in the diagnosis of thoracic metastasis.

Author

Saraya T, Yokoyama T, Ishii H, Tanaka Y, Tsujimoto N, Ogawa Y, Sohara E, Nakajima A, Inui T, Sayuki H, Fujiwara M, Oka T, Kawachi R, Goya T, Takizawa H, and Goto H

Abstract

A 47-year-old man was referred to our hospital because of a 2-month history of dry cough, 2-kg weight loss, and a feeling of abdominal fullness. The PET-CT scan depicts the intense standard uptake values (SUVs) of the anterior and subphrenic lymphnodes, and intraperitoneal cavity, especially in the omentum, while, no uptake was found in the pleural cavity. Based on the pathological findings of the open lung biopsy specimens, he was diagnosed with malignant peritoneal mesothelioma of epithelioid type with thoracic metastasis. The present case demonstrated the some of the limitations of PET-CT in the diagnosis of malignant mesothelioma, which failed to detect pleural involvement despite aggressive invasion by this tumor.

Published
2013
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37. Guillain-Barré syndrome in two patients with respiratory failure and a review of the Japanese literature.

Author

Sohara E, Saraya T, Honda K, Yamada A, Inui T, Ogawa Y, Sada M, Tsujimoto N, Nakamura M, Tsuchiya A, Saito M, Oishi C, Chiba A, Takizawa H, and Goto H

Abstract

We described two patients with Guillain-Barré syndrome and respiratory failure with or without mechanical ventilation. Case 1 was a 44-year-old man who treated as pneumonia under mechanical ventilation for a month and transferred to our hospital with unsuccessful weaning trials because of phrenic nerve palsy. Case 2 was a 74-year-old man who presented with aspiration pneumonia because of bulbar palsy. The present two cases with review of the Japanese literature showed that antecedent infection with initial symptoms within the most recent 5 to 46 days is a clinical clue to the diagnosis even in patients with Guillain-Barré syndrome accompanied by respiratory failure.

Published
2012
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